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Bibliografias temáticas / 'fitness' clonal

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Literatura científica selecionada sobre o tema "'fitness' clonal"

Autor: Grafiati

Publicado: 14 de dezembro de 2024

Última modificação: 31 de julho de 2025

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Artigos de revistas sobre o assunto "'fitness' clonal"

1

Wikberg, Sofie. "Fitness in Clonal Plants." Oikos 72, no. 2 (1995): 293. http://dx.doi.org/10.2307/3546232.

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Watson, Caroline J., A. L. Papula, Gladys Y. P. Poon, et al. "The evolutionary dynamics and fitness landscape of clonal hematopoiesis." Science 367, no. 6485 (2020): 1449–54. http://dx.doi.org/10.1126/science.aay9333.

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Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely unknown. Blood sequencing data from ~50,000 individuals reveal how mutation, genetic drift, and fitness shape the genetic diversity of healthy blood (clonal hematopoiesis). We show that positive selection, not drift, is the major force shaping clonal hematopoiesis, provide bounds on the number of hematopoietic stem cells, and quantify the fitness advantages of key pathogenic variants, at single-nuc

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Burns, Thomas P. "Fitness in Clonal Organisms: A Special Case of Extensive Fitness." Oikos 65, no. 3 (1992): 535. http://dx.doi.org/10.2307/3545572.

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Pan, Jean J., and Jason S. Price. "Fitness and evolution in clonal plants: the impact of clonal growth." Evolutionary Ecology 15, no. 4-6 (2001): 583–600. http://dx.doi.org/10.1023/a:1016065705539.

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Barrett, Spencer C. H. "Influences of clonality on plant sexual reproduction." Proceedings of the National Academy of Sciences 112, no. 29 (2015): 8859–66. http://dx.doi.org/10.1073/pnas.1501712112.

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Flowering plants possess an unrivaled diversity of mechanisms for achieving sexual and asexual reproduction, often simultaneously. The commonest type of asexual reproduction is clonal growth (vegetative propagation) in which parental genotypes (genets) produce vegetative modules (ramets) that are capable of independent growth, reproduction, and often dispersal. Clonal growth leads to an expansion in the size of genets and increased fitness because large floral displays increase fertility and opportunities for outcrossing. Moreover, the clonal dispersal of vegetative propagules can assist “mate

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Avagyan, S., J. E. Henninger, W. P. Mannherz, et al. "Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis." Science 374, no. 6568 (2021): 768–72. http://dx.doi.org/10.1126/science.aba9304.

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Colorful clones in the blood Stem cells in regenerating tissues such as the blood can acquire mutations that enable a growth advantage, increasing the chance of developing cancer. It is unclear how such diverse mutations promote clonal fitness. Avagyan et al . generated a platform in zebrafish to label clones with unique hues while inducing mutations in genes implicated in human blood disorders. Mutations in some genes caused clones to expand over time, resulting in clonal dominance. Progenitors in the dominant clone expressed anti-inflammatory factors to resist the inflammatory environment pr

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Skums, Pavel, Viachaslau Tsyvina, and Alex Zelikovsky. "Inference of clonal selection in cancer populations using single-cell sequencing data." Bioinformatics 35, no. 14 (2019): i398—i407. http://dx.doi.org/10.1093/bioinformatics/btz392.

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Abstract Summary Intra-tumor heterogeneity is one of the major factors influencing cancer progression and treatment outcome. However, evolutionary dynamics of cancer clone populations remain poorly understood. Quantification of clonal selection and inference of fitness landscapes of tumors is a key step to understanding evolutionary mechanisms driving cancer. These problems could be addressed using single-cell sequencing (scSeq), which provides an unprecedented insight into intra-tumor heterogeneity allowing to study and quantify selective advantages of individual clones. Here, we present Sing

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Derbal, Youcef. "Cell Adaptive Fitness and Cancer Evolutionary Dynamics." Cancer Informatics 22 (January 2023): 117693512311546. http://dx.doi.org/10.1177/11769351231154679.

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Genome instability of cancer cells translates into increased entropy and lower information processing capacity, leading to metabolic reprograming toward higher energy states, presumed to be aligned with a cancer growth imperative. Dubbed as the cell adaptive fitness, the proposition postulates that the coupling between cell signaling and metabolism constrains cancer evolutionary dynamics along trajectories privileged by the maintenance of metabolic sufficiency for survival. In particular, the conjecture postulates that clonal expansion becomes restricted when genetic alterations induce a suffi

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Fuzi, Miklos, and Evgeni Sokurenko. "Commensal Fitness Advantage May Contribute to the Global Dissemination of Multidrug-Resistant Lineages of Bacteria—The Case of Uropathogenic E. coli." Pathogens 12, no. 9 (2023): 1150. http://dx.doi.org/10.3390/pathogens12091150.

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It is widely accepted that favorable fitness in commensal colonization is one of the prime facilitators of clonal dissemination in bacteria. The question arises as to what kind of fitness advantage may be wielded by uropathogenic strains of the two predominant fluoroquinolone- and multidrug-resistant clonal groups of E. coli—ST131-H30 and ST1193, which has permitted their unprecedented pandemic-like global expansion in the last few decades. The colonization-associated genes’ content, carriage of low-cost plasmids, and integrons with weak promoters could certainly contribute to the fitness of t

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Gordo, Isabel, and Paulo R. A. Campos. "Evolution of clonal populations approaching a fitness peak." Biology Letters 9, no. 1 (2013): 20120239. http://dx.doi.org/10.1098/rsbl.2012.0239.

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Populations facing novel environments are expected to evolve through the accumulation of adaptive substitutions. The dynamics of adaptation depend on the fitness landscape and possibly on the genetic background on which new mutations arise. Here, we model the dynamics of adaptive evolution at the phenotypic and genotypic levels, focusing on a Fisherian landscape characterized by a single peak. We find that Fisher's geometrical model of adaptation, extended to allow for small random environmental variations, is able to explain several features made recently in experimentally evolved populations

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Teses / dissertações sobre o assunto "'fitness' clonal"

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Goho, Shaun Alaric. "The accumulation of variance in fitness in clonal populations of Chlamydomonas reinhardtii in normal and stressful environments." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/MQ29703.pdf.

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Goho, Shaun. "The accumulation of variance in fitness in clonal populations of Chlamydomonas reinhardtii in normal and stressful environments /." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27328.

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The work presented here investigates two basic properties of mutation rates in the unicellular chlorophyte Chlamydomonas reinhardtii. The first chapter is devoted to an investigation of the mutational heritability $ rm (V sb{M})$ of fitness in asexually propagated populations. This is the rate at which novel variation for fitness accumulates in a population. In two trials, values of $ rm V sb{M}$ = 4.5 and $4.7 times 10 sp{-3}$ of the environmental variance $ rm (V sb{E})$ were obtained. These values were at least an order of magnitude greater than estimates from other organisms of $ rm V sb{M

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Bertrand, Alexis. "Caractérisation fonctionnelle de mutations somatiques compensatrices d'elF6 dans le contexte du syndrome de Shwachman- Diamond." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL089.

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Le syndrome de Shwachman Diamond (SDS) est une ribosomopathie génétique rare entraînant une altération de la synthèse protéique associée à de nombreux symptômes, notamment une insuffisance médullaire et une neutropénie pouvant évoluer vers un syndrome de myélodysplasie ou une leucémie myéloïde aiguë. Les mutations bialléliques du gène SBDS sont responsables de plus de 90 % des cas de SDS et nous avons récemment identifié des mutations bialléliques EFL1 comme une nouvelle cause génétique de SDS. SBDS et EFL1 évincent le facteur elF6 de la sous-unité ribosomale pré60S, permettant à cette dernièr

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Alqasim, A. S. "Determining the fitness and competitive advantage of the epidemic ExPEC clone E. coli ST131." Thesis, Nottingham Trent University, 2015. http://irep.ntu.ac.uk/id/eprint/27912/.

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Extraintestinal pathogenic E. coli (ExPEC) is the major aetiological agent of urinary tract infections (UTIs) in humans. The emergence of the CTX-M producing E. coli ST131 clone represents a major challenge to public health worldwide because of its ability to cause a wide range of difficult-to-treat infections in the healthcare and community settings. The key aim of this study was to characterise the traits that give E. coli ST131 a competitive fitness advantage over other potential ExPEC clones. Comparative phenotypic characterisation of a collection of ExPEC strains showed that there was no

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Allander, Lisa. "Fitness and virulence of epidemic and non-epidemic clones of extensively drug-resistant (XDR) carbapenemase-producing Klebsiella pneumoniae." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356714.

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6

Ferriol, Safont Inmaculada. "FACTORS INVOLVED IN THE EVOLUTION OF BROAD BEAN WILT VIRUS 1 AND TOBACCO MOSAIC VIRUS." Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/16000.

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Los virus producen graves pérdidas económicas en la agricultura. Esta problemática es muy dinámica ya que cada año aparecen nuevas virosis y es frecuente los fenómenos de emergencia con una rápida expansión de los virus. El control de las enfermedades víricas resulta poco eficaz en muchos casos porque la población viral es capaz de evolucionar y superar dichas estrategias. Por ello es clave entender la dinámica de las poblaciones y los factores implicados en la evolución de los virus con respecto a distintos aspectos de su biología del ciclo viral: replicación, movimiento dentro de la planta,

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Mariette, Nicolas. "Traits de vie,adaptation et pouvoir invasif de lignées clonales de Phytophthora infestans, agent du mildiou de la pomme de terre." Thesis, Rennes, Agrocampus Ouest, 2016. http://www.theses.fr/2016NSARA075/document.

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Les populations ouest européennes de Phytophthora infestans, l’oomycète responsable du mildiou chez la pomme de terre, sont caractérisées par une structure clonale et un remplacement rapide des lignées dominantes. Cette thèse visait à identifier les déterminants écologiques, phénotypiques et évolutifs du caractère invasif de ces lignées clonales. Pour cela, les dynamiques génotypiques et phénotypiques de populations ont été analysées sur deux échelles de temps, l’une sur près d’une décennie et l’autre via un suivi longitudinal sur deux épidémies consécutives. Ces suivis étaient complétés par l

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Duprilot, Marion. "Étude comparative du clade émergent de Escherichia coli ST131 O25b H4 de son clade progéniteur : fitness in vitro et in vivo et formation de biofilm." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/DUPRILOT_Marion_va.pdf.

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Le clade C de Escherichia coli ST131, pathogène extra-intestinal (ExPEC) multirésistant aux antibiotiques, a émergé dans le monde entier au début des années 2000. La compréhension de son essor fait partie des enjeux majeurs de santé publique. Pour participer à cette compréhension, nous avons pris en considération l’histoire phylogénique de ST131 et axé nos recherches sur la comparaison du clade C avec son progéniteur, le clade B, qui est lui composé de souches globalement sensibles aux antibiotiques. L’histoire phylogénétique du clone ST131 décrit la diversification du clade B ancestral en dif

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Livros sobre o assunto "'fitness' clonal"

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A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Humana Press, 2003.

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2

A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Humana Press, 2003.

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3

A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Humana Press, 2003.

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4

Birch, Jonathan. The Multicellular Organism as a Social Phenomenon. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198733058.003.0007.

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As Hamilton observed, the stability of cooperation within clonal groups of cells is no mystery, since the cells’ inclusive fitness interests are aligned. However, the process of social group transformation, by means of which a social group of cells is transformed into a multicellular individual with a division of labour among multiple cell types, remains mysterious. In both multicellular organisms and eusocial insects, group size and the number of specialized types are closely linked. As Bourke has argued, positive feedback is likely to be crucial in explaining the relationship between size an

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5

ON CLONING. ROUTLEDGE, 2004.

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6

Voll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms

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7

Machida, Curtis A. Viral Vectors for Gene Therapy: Methods and Protocols (Methods in Molecular Medicine). Humana Press, 2002.

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Capítulos de livros sobre o assunto "'fitness' clonal"

1

Pan, Jean J., and Jason S. Price. "Fitness and evolution in clonal plants: the impact of clonal growth." In Ecology and Evolutionary Biology of Clonal Plants. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-1345-0_20.

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Boomsma, Jacobus J. "Inclusive fitness as driver of cooperation for mutual benefit." In Domains and Major Transitions of Social Evolution. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780198746171.003.0005.

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Abstract Mutual aid cannot evolve unless it offers compensating direct benefits for an actor or indirect benefits for her relatives. This phrase is a gene’s eye version of Darwin’s statement that no adaptation can arise for the exclusive good of another species. Such thinking has inspired studies that explored how Hamilton’s rule can explain adaptation in symbiotic mutualisms. When studies tracked genetics, they converged on the conclusion that interspecific “altruism” is always driven by clonal or family altruism within the partner species, which confirmed Darwin’s insight and earlier conclus

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Roff, Derek A. "Invasibility Analysis." In Modeling Evolution an introduction to numerical methods. Oxford University PressOxford, 2009. http://dx.doi.org/10.1093/oso/9780199571147.003.0003.

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Abstract An alternative approach to that used in the last chapter is invasibility analysis, which consists of asking if a clone displaying an alternate life history can invade a resident population. While one could compare results for markedly different life histories, in general, invasibility analysis has been used to locate the optimal combinations of parameter values rather than qualitatively different life histories. As with the “Fisherian” optimality approach, sexual reproduction is ignored. Invasibility analysis is used extensively, and is most useful, when fitness is density-dependent a

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Voll, Reinhard E., and Barbara M. Bröker. "Innate vs acquired immunity." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048_update_001.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms

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Trabalhos de conferências sobre o assunto "'fitness' clonal"

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Bolton, Kelly L., Ryan N. Ptashkin, Teng Gao, et al. "Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5703.

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Bulanova, Nina, Arina Buzdalova, and Maxim Buzdalov. "Fitness-Dependent Hybridization of Clonal Selection Algorithm and Random Local Search." In GECCO '16: Genetic and Evolutionary Computation Conference. ACM, 2016. http://dx.doi.org/10.1145/2908961.2908996.

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Jameson, Katherine L., Peter L. Frick, Darren R. Tyson, Thomas E. Yankeelov, and Vito Quaranta. "Abstract 3747: Identification of NSCLC biomarkers underlying quantifiable drug-induced clonal fitness." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3747.

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Relatórios de organizações sobre o assunto "'fitness' clonal"

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Morin, S., L. L. Walling, Peter W. Atkinson, J. Li, and B. E. Tabashnik. ets for CRISPR/Cas9-mediated gene drive in Bemisia tabaci. United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134170.bard.

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The goal of our BARD proposal was to build both the necessary infrastructure and knowledge for using the CRISPR/Cas9-based gene drive system to control the whitefly Bemisia tabaci. Our research focused on achieving three main goals: (1) establishing a CRISPR/Cas9 gene-editing system for producing genetically-edited B. tabaci; (2) generating and testing CRISPR/Cas9-mediated mutations targeting genes that represent two gene drive strategies: population replacement and population suppression; (3) using computer modeling to optimize strategies for applying CRISPR/Cas9 to control B. tabaci populati

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