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Teses / dissertações sobre o tema "Glycoproteins"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

Jefferies, W. A. "Lymphocyte surface glycoproteins." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355757.

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2

Clark, R. A. C. "Characterisation of neural glycoproteins." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363826.

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3

Premdjee, B. "Semi-synthesis of glycoproteins." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1434897/.

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Glycosylation is a prevalent form of post translational modification, believed to occur on over 50% of human proteins. Homogeneous forms of glycoproteins are essential for developing an understanding of how activity is mediated at a structural level. As biological origins of glycoproteins give rise to complex mixtures of glycoforms, homogeneous glycoprotein production has become an important goal. As chemical protein synthesis is often limited to sequences of 30-50 residues, access to large native glycoproteins is currently restricted to fragment based approaches. Protein semi-synthesis enable

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4

Crispin, Matthew D. M. "Manipulation and crystallisation of glycoproteins." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426374.

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5

Priyanka, Pragya. "Chemoenzymatic synthesis of phosphorylated glycoproteins." Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/10578.

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Phosphorylation of the glycan portion of glycoproteins is an important posttranslational modification. In particular, the presence of mannose-6-phosphate (M6P) residues on high mannose glycans of lysosomal enzymes is important for the transfer of these enzymes to the lysosomes. The synthesis of different types of N-glycan structures containing M6P residues have been reported by various groups. This thesis work concerns the chemoenzymatic synthesis of phosphorylated glycoproteins, wherein M6P containing N-glycans were synthesised chemically and then enzymatically coupled to give homogeneous gly

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6

Duffy, Iain. "Analysis of measles virus glycoproteins." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324842.

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7

Kaye, Jane Frances. "Studies of human cytomegalovirus glycoproteins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259731.

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8

BECKMANN, M. PATRICIA. "SYNTHESIS AND OLIGOSACCHARIDE PROCESSING OF NORMAL AND ALTERED IMMUNOGLOBULIN M DURING B-CELL DIFFERENTIATION (GLYCOPROTEIN, GLYCOPEPTIDE, MUTANT, CARBOHYDRATE, ASPARAGINE-LINKED)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187906.

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Glycoproteins play a key role in cellular growth and differentiation. In order to study glycoprotein biosynthesis and processing, we have chosen the murine Immunoglobulin M (IgM) system as a model. Our system utilizes hybridoma, lymphoma and plasmacytoma cell lines which synthesize intracellular, membrane-bound and secreted IgM. Each type of IgM is synthesized during a specific phase of B-cell differentiation. We have examined the kinetics of IgM synthesis and processing in cells at each developmental stage. The rate of synthesis of membrane-bound and soluble IgM are different. Characteristic

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9

Chan, Chun-yu. "Mass spectrometric analysis of selected glycoproteins." Thesis, Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B3147942X.

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10

Perry, J. Jefferson P. "Structural studies of cell surface glycoproteins." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368608.

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11

Edwards, Cathryn M. "Mucus glycoproteins in the diverted colorectum." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365830.

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12

Sage, Karen Anne. "The synthesis of glycopeptides and glycoproteins." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360466.

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13

Gupta, G. "Artificial lectins : biomimetic ligands for glycoproteins." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599789.

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This thesis describes the rational design and synthesis of selective and sterilisable biomimetic ligands for the resolution of glycosylated and carbohydrate depleted protein forms. Based on the principles of natural carbohydrate recognition, a putative library of 196 glycoprotein-binding ligands was designed and synthesised by solid phase combinatorial approaches. A preparative affinity chromatography screening assay against a well-characterised complex-type model glycoprotein, helped identify a triazine-based acyclic immobilised ligand 11/11, comprising <I>bis</I>-benzylamine substituents as

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14

Juhasz, Katalin. "Major glycoproteins of turkey rhinotracheitis virus." Thesis, University of Warwick, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283496.

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15

Bristow, Richard G. W. "Antibody recognition of HIV-1 glycoproteins." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315370.

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16

Stephenson-Brown, Alexander James. "Synthetic sensors for saccharides and glycoproteins." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5728/.

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The sensing of biological compounds is of vital importance to the screening and diagnosis of disease. The importance of such assays is due to the correlation observed between the observed levels of biological compounds and diseases such as cancer and diabetes mellitus. Compounds such as sugars and proteins are included in this useful class of molecules which can be used to detect pathology. Currently the detection of these compounds is achieved through the use of other biologically derived molecules- typically antibodies and enzymes. However, sensors based on these compounds can be limited in

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17

Wood, Sarah Louise. "Glycoproteins of the chromaffin granule membrane." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19427.

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18

Demers, Audrey Gertrude. "Structural studies of glycoproteins in solution." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054759177.

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19

Macmillan, Derek. "The synthesis of novel homogeneous glycoproteins." Thesis, University of Edinburgh, 1999. http://webex.lib.ed.ac.uk/abstracts/macmil01.pdf.

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20

Vasiliauskaite, Ieva. "Structural characterization of viral envelope glycoproteins." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066507/document.

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Les glycoprotéines virales sont impliquées dans les deux principales étapes d’entrée des virus enveloppés dans leurs cellules hôtes : l’attachement des virus aux récepteurs cellulaires et la fusion des membranes virale et cellulaire. Je me suis d’abord attachée à l’étude structurale de la principale glycoprotéine, E2, de deux hépacivirus : la forme B du virus GB (GBV-B) et le virus de l’hépatite C (HCV). Mes tentatives de cristallisation de l’ectodomaine de la protéine E2 du GBV-B sont restées vaines, mais l’analyse des propriétés de ses fragments a suggéré un rôle de son extrémité C-terminale

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21

Vasiliauskaite, Ieva. "Structural characterization of viral envelope glycoproteins." Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066507.pdf.

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Les glycoprotéines virales sont impliquées dans les deux principales étapes d’entrée des virus enveloppés dans leurs cellules hôtes : l’attachement des virus aux récepteurs cellulaires et la fusion des membranes virale et cellulaire. Je me suis d’abord attachée à l’étude structurale de la principale glycoprotéine, E2, de deux hépacivirus : la forme B du virus GB (GBV-B) et le virus de l’hépatite C (HCV). Mes tentatives de cristallisation de l’ectodomaine de la protéine E2 du GBV-B sont restées vaines, mais l’analyse des propriétés de ses fragments a suggéré un rôle de son extrémité C-terminale

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22

Ritchie, Gayle E. "The glycosylation of viral envelope glycoproteins and the effect of glycosidase inhibitors on virus replication and glycoprotein properties." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442908.

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23

Fyrner, Timmy. "Synthesis of Structures Related to Antifreeze Glycoproteins." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11941.

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<p>In this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthal

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24

Kramer, Holger. "Synthesis of Glycoproteins and C-linked Glycopeptides." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487272.

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Protein glycosylation is of great importance in nature due to its significance towards protein folding and stability, cell-cell communication and immunology. This thesisÃ‚Â·reports strategies that allow the synthesis of glycoprotein mimics as single glycoforms. This has been achieved through a combination of site-directed mutagenesis with unnatural amino acid incorporation and subsequent orthogonal chemical modification. The method also extends to the preparation of differentially modified glycoprotein mimics by means of two mutually orthogonal modification reactions. In addition to that, the

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25

Späte, Anne-Katrin [Verfasser]. "Metabolic Engineering of Glycoproteins / Anne-Katrin Späte." Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1114893870/34.

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26

Hemming, Richard John. "Radioautographical and biochemical studies on nucleoplasmic glycoproteins." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41298.

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EM radioautography was used to examine the tissue distribution of cells exhibiting nucleoplasmic labeling after being exposed to $ sp3$H-sugars or $ sp{35}$S-sulphate to indicate the general extent of the occurrence of nucleoplasmic glycoproteins within animal cells. The observation of some degree of such labeling in virtually all cells in tissues of three animal species suggests that nucleoplasmic glycoproteins are a common cellular feature. To better define the distribution and nature of the putative labeled nucleoplasmic glycoproteins, cultured cells were used as a model cell type for both

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27

Krishna, Sudhir. "T cell recognition of HSV-1 glycoproteins." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317944.

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28

Smyth, Edward. "Raman optical activity of proteins and glycoproteins." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312130.

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29

Field, Mark C. "Structural studies on oligosaccharides from mammalian glycoproteins." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:163fb9d7-43b7-4347-ab81-ce3cb87cb3f9.

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30

Snowden, B. W. "Structural and functional studies of herpesvirus glycoproteins." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355709.

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31

Fielding, Adel Kay. "Targeting fusogenic retroviral glycoproteins by ligand display." Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322305.

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32

Spring, F. A. "Surface glycoproteins of normal and leukaemic leucocytes." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370674.

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33

Zeng, Chenhui. "Structure determination of glycoproteins by mass spectrometry." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/40167.

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34

Graham, Richard Peter. "Purification of glycoproteins from herpes simplex virus." Master's thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/25694.

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The aim of this work was to purify type-specific glycoproteins from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) for diagnostic use. The most likely candidate for a type-specific glycoprotein of HSV-1 is glycoprotein C (gC), although it has recently been shown to contain some type-common antigenic determinants. HSV-1 and HSV-2 were produced in BHK-21 cells and labelled with either (³H)-glucosamine ((³H)-gln) or a mixture of (¹⁴C)-amino acids ((¹⁴C)-aa). Analysis of the radiolabelled products by analytical sodium dodecyl sulphate polyacrylamide gel electrophoresis (SOS-PAGE) and autor

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35

Soby, Lynn Margaret. "Structure and viscoelasticity of proteoglycans and glycoproteins." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1059058747.

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36

Wang, Siyao. "Total Synthesis of Homogeneous Glycopeptides and Glycoproteins." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18329.

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Glycosylation is a ubiquitous post-translational modification of proteins. Access to pure glycoproteins is extremely challenging owing to the enzymatic glycosylation process which is not templated and, as such, affords heterogeneous mixtures of glycoforms. Chemical synthesis provides an attractive avenue to access homogeneously glycosylated peptides and proteins, thus providing a means to elucidate the role of specific glycan modifications on structure and function. This thesis outlined the development of a number of novel synthetic methods to access biologically important glycopeptides and

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37

D'Souza, Yvonne. "Glycoproteins of drusen and drusen-like lesions." Thesis, University of Manchester, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489005.

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38

Bill, Roslyn M. "A study towards the chemical glycosylation of recombinant human erythroprotein." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240573.

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39

Byth, Katharine Fiona. "The targeted disruption of the CD45 gene in transgenic mice." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336538.

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40

Tomlinson, Michael Graham. "Structure and function of the leukocyte and surface antigens CD53 and CD37." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308502.

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41

Lam, Ka-wai, and 林嘉維. "Glycodelin-A as a modulator of trophoblast invasion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45598964.

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42

Kemp, Pauline Anne. "The glycosylation of human alpha-1-antitrypsin expressed in transgenic mouse milk." Thesis, University of Kent, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298167.

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43

Runswick, Sarah Kay. "Expression of laminin in the developing central nervous system of the chick embryo." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295823.

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44

Haston, Jennifer Louise. "The inhibition of type II collagen fibril formation in rheumatoid arthritis." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248329.

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45

Malloy, Andrew Robert. "Atomic force microscopy studies of glycophorin A-BRAC 30 antigen-antibody interactions." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247173.

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46

Molesworth, Sara J. I. M. "Expression and assembly of the Epstein-Barr virus (EBV) gp85, gp25 and gp42 fusion complex in the baculovirus system." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361142.

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47

Dee, Valerie Murielle. "Multiple forms of human complement factor H." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670272.

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48

Cheng, Chi-keung. "Structural organization of the mouse testin gene and characterization of its promoter sequence." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22424763.

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49

Perrine, Cynthia L. "Profiling Glycosyltransferase Peptide Substrate Specificities: Studies on ppGalNAc T1, T2, T10, and T-synthase That Initiate Mucin-Type O-Glycosylation." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1253046997.

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Thesis(Ph.D.)--Case Western Reserve University, 2009<br>Title from PDF (viewed on 2009-12-30) Department of Chemistry Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center

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50

Sabry, Zaki Tlep Sahar. "Identification of the molecular origins of disease in a cohort of patients with suspected congenital disorders of glycosylation (CDG)." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066715/document.

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Contexte : Les désordres congénitaux de la glycosylation (CDGs) sont des maladies rares dues à des mutations dans des gènes codant pour des protéines de la biosynthèse des glycoconjugués. Les CDGs présentent avec des glycoprotéines sériques hypoglycosylées avec un spectre clinique large. Le diagnostic moléculaire des CDG est important dans le cadre du diagnostic prénatal et du développement de stratégies thérapeutiques. Objectif : Déterminer les mutations causales dans une cohorte de cas suspects de CDG. Deux cas ont fait l’objet d’explorations biochimiques afin de comprendre les conséquences

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