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Teses / dissertações sobre o tema "Heart Effect of drugs on"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 31 de janeiro de 2023

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1

Zeitz, Christopher John. "Acute drug effects on the heart-haemodynamic, pharmacologic and metabolic correlations." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phz48.pdf.

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Addenda and corrigenda inserted on verso of back end paper. Includes: Publications and communications to learned societies (p. 4-5). Bibliography: leaves 272-286. Examines the acute myocardial uptake of drugs, particularly perindoprilat and enalaprilat in humans. The uptake of these agents is examined, together with the haemodynamic, metabolic and biochemical effects. In particular, the impact of these agents on angiotensin and bradykinin peptides both within the heart and peripherally is described. The acute effects of a range of cardioactive drugs upon the left ventricular force-interval rel

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2

Maune, Jerene Mary 1953. "THE EFFECT OF CAFFEINE ON HEART RATE, RHYTHM AND BLOOD PRESSURE." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276372.

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3

Ramadan, Waile Rushing Ann E. Hartberg W. Keith. "The protective effect of [alpha]-lipoic acid in doxorubicin induced cardiotoxicity in rats." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5218.

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4

Li, Y. M. J. "An in-vivo study of the anti-arrhythmic and electrophysiological effects of amiodarone, lignocaine and penticainide (CM7857) in the rat." Thesis, De Montfort University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233821.

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5

Huang, Yi Fei. "Myocardial pharmacokinetics and pharmacodynamics in the sheep /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phh8742.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Anaesthesia and Intensive Care, 1992.<br>Accompanying diskette contains data of Chapters 3, 4, 5, 7, 8 and 9 (ASCII). Includes bibliographical references (leaves 177-207).

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6

Ritchie, Rebecca Helen. "Acute haemodynamic effects of three cardioactive agents: metoprolol, sotalol and milrinone : influence of myocardial content and systolic interval /." Title page, table of contents and summary only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phr611.pdf.

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7

Shubat, Pamela Jane. "Monocrotaline toxicity and pulmonary arteries." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184533.

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Monocrotaline is a pyrrolizidine alkaloid found in plants implicated in livestock and human poisoning. Laboratory rats given monocrotaline develop pulmonary hypertension and right heart hypertrophy in the weeks following administration of the chemical. Lung weight increases and right heart hypertrophy correlate with increased pulmonary artery pressure. Rats which consumed monocrotaline drinking water (20 mg/l) for only 4 days developed significant increases in lung and heart weights 14 days after exposure began. This exposure was equivalent to a dose of 15 mg/kg. Other treatment combinations o

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8

Rossouw, Ellen. "The effect of androgenic anabolic steroids on the susceptibility of the rat heart to ischaemia and reperfusion injury." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53105.

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Thesis (MSc)--University of Stellenbosch, 2002.<br>ENGLISH ABSTRACT: Background: Athletes use androgenic anabolic steroids (AAS) to enhance their physical performance. The abuse of AAS is however associated with a host of side effects including sudden death due to cardiac arrest. The use of AAS leads to myocardial hypertrophy, which possibly makes the heart more prone to ischaemia/reperfusion injury, since it often develops in the absence of proper vasculature development. Chronic AAS use also disrupts myocardial p-adrenoreceptor function and possibly cAMP, signalling in the heart. Dru

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9

Leigh, Felicity Suzanne Marshall. "The effects of diet, anorectic drugs and caffeine on various cardiovascular parameters in the rat." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382595.

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10

Kalis, Joni Kathryn. "THE EFFECT OF BETA-ADRENERGIC BLOCKADE ON THE DRIFT IN OXYGEN CONSUMPTION WITH PROLONGED EXERCISE." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/292014.

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11

Santos, Priscila Portugal [UNESP]. "Influência da suplementação de dieta com diferentes doses de vitamina D sobre variáveis cardíacas em ratos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/92124.

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Made available in DSpace on 2014-06-11T19:25:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-28Bitstream added on 2014-06-13T18:53:45Z : No. of bitstreams: 1 santos_pp_me_botfm.pdf: 349987 bytes, checksum: 913fc9a75063c45bd784ef00c6dc221f (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A frequência de hipovitaminose D é alta na população. A deficiência de vitamina D tem sido considerada problema de saúde pública no Brasil e no mundo. Além disso, a deficiência dessa vitamina está associada com o aumento do risco de várias doenças crônicas. Assim, e

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12

Azarbayjani, Faranak. "Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5065-2/.

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13

Persson, Kirstin Gracia. "In vivo effects of crinum macowanii on the rat cardiovascular system." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4721_1222073945.

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<p>Crinum macowanii (C. macowanii) (Amaryllidacea) as authenticated by Mr. F. Weitz at the Herbarium, University of the Western cape, is widely used a traditional remedy and is thought to have therapeutic value (Fennell and van Staden 2001). The objective of this study was to determine the cardiovascular effects of the crude aqueous extract of Crinum macowanii on the rat and to determine the effect of pre-treatment drugs on Crinum macowanii in in vivo, anaesthetized normotensive, male Wistar rats (200-250 g.).</p>

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14

Gharanei, A. M. "Investigation into the cardiotoxic effects of doxorubicin and strategies for cardioprotection." Thesis, Coventry University, 2013. http://curve.coventry.ac.uk/open/items/ad712004-828e-4d9a-8ddb-17951146d414/1.

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Doxorubicin is one of the most effective anti-cancer agents; however its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure. Mitochondrial function and integrity are crucial for cellular processes in general and play an important role during diseased development. These characteristics of the mitochondria make them the prime target for treatments for majority of diseases and in particular of the cardiovascular system. The mitochondria are also considered to play an integral role in the manifestation of the cardiotoxic effects of compounds such

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15

Santos, Priscila Portugal. "Influência da suplementação de dieta com diferentes doses de vitamina D sobre variáveis cardíacas em ratos /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/92124.

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Resumo: A frequência de hipovitaminose D é alta na população. A deficiência de vitamina D tem sido considerada problema de saúde pública no Brasil e no mundo. Além disso, a deficiência dessa vitamina está associada com o aumento do risco de várias doenças crônicas. Assim, está ocorrendo uso indiscriminado de vitamina D sem conhecer ao certo seus efeitos adversos. Estudos mostraram que essa vitamina é importante para o desenvolvimento e funcionamento adequado do coração. A deficiência de vitamina D provoca remodelação cardíaca enquanto que a suplementação de vitamina D, em modelos de agressão,

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16

Komulainen, S. (Silja). "Effect of antihypertensive drugs on blood pressure during exposure to cold:experimental study in normotensive and hypertensive subjects." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286131.

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Abstract The aim of the present study was to describe the effects of different types of cold exposures on blood pressure (BP) and heart rate (HR) and to test how these cold-induced effects are modulated by antihypertensive drugs representing different kind of mechanisms of action. The tested drugs represented the following antihypertensive drug subgroups: metoprolol from beta-blocking agents, carvedilol from alfa- and beta-blocking agents, lisinopril from angiotensin converting enzyme inhibitors, eprosartan from angiotensin II antagonists, amlodipine from calcium channel blockers and hydrochlo

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17

Arstall, Margaret Anne. "Studies in myocardial ischaemia and infarction : effects of N-acetylcysteine on oxidative stress and myocardial salvage /." Title page, contents and summary only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09pha783.pdf.

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18

Mattern, Janet. "Muscarinic Receptor Modulation of the Phospholipid Effect in Cardiac Myocytes." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500469/.

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The muscarinic agonist carbachol stimulates a rapid increase in ^32Pi incorporation into phosphatidic acid (PA) and phosphatidylinositol (PI) in calcium tolerant myocytes prepared from heart tissue. The density of muscarinic receptors, determined by [^3H]-QNB binding, is greater in the atria than in the ventricles. 250 uM carbachol decreased specific [^3H]-QNB binding to muscarinic receptors on myocyte membranes by fifty percent. Trifluoperazine, also a phospholipase C inhibitor, inhibited the carbachol stimulated increase in ^32Pi incorporation into PA and PI and did not interfere with muscar

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19

Badrian, Bahareh. "Evaluation of the consequences of ERK and STAT3 activation in the heart." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0027.

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[Truncated abstract] The enlargement of the heart, also known as myocardial hypertrophy, is thought to be a compensatory process that maintains the mechanical function of the heart in response to stress factors such as pressure or volume overload. Although this process is initially compensatory, it frequently results in heart failure and death. Cardiac hypertrophy is a complex process involving changes in the individual cardiac muscle cells, cardiac myocytes. As well as the morphological changes that result from hypertrophy, there are molecular changes within each cell that regulate the hypert

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20

Davidson, Melissa Anne. "A Pharmacovigilance Approach for Assessing Cardiovascular, Osteological, and Carcinogenic Risk Associated with Thiazolidinedione Drugs Used in the Treatment of Type 2 Diabetes Mellitus." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38062.

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Diabetes is a chronic and debilitating disease that affects nearly half a billion people worldwide with the vast majority of diabetics suffering from Type 2 diabetes mellitus (T2DM), a disease characterized by insulin insensitivity that often requires pharmacotherapy to effectively maintain target blood sugar levels. The thiazolidinedione (TZD) class of drugs consists of oral hypoglycaemic agents used alone or in combination with other antidiabetic drugs to treat T2DM. The drugs within this class, which include rosiglitazone and pioglitazone, were originally heralded as providing novel first a

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21

Branco, Klébia Magalhães Pereira Castello. "Análise clínica evolutiva do uso do tacrolimus como droga imunossupressora em transplante cardíaco pediátrico." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-24052011-163915/.

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O Tacrolimus é uma potente droga imunossupressora introduzida no transplante cardíaco no início da década de 90. Pacientes com rejeição refratária ou intolerância à ciclosporina podem responder à terapia de resgate com o tacrolimus. Os objetivos deste estudo foram: avaliar a evolução clínica das crianças submetidas ao transplante cardíaco que necessitaram da conversão de ciclosporina para tacrolimus por rejeição refratária, tardia ou efeitos adversos de difícil controle; avaliar a incidência de rejeição após a conversão para o tacrolimus e comparar a sobrevida dos pacientes em uso de tacrolimu

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22

Boachie-Ansah, G. "Adenyl compounds, adrenoreceptor activation, and acute ischaemia-related cardiac arrhythmias." Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382268.

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23

Cook, Andrew T. "The effect of accelerated aging on peelable medical products seals /." Online version of thesis, 1994. http://hdl.handle.net/1850/11980.

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24

Weise-Kelly, Lorraine Ann. "Drug-induced ataxia : effect of the self-administration contingency /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0030/NQ66245.pdf.

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25

Capewell, Simon. "Studies of the calcium antagonist felodipine in the treatment of hypertension and heart failure." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330281.

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26

Nicholas, Jacob. "Studies in the use of mexiletine in the coronary care unit." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329369.

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27

Bai, Shuang. "Effect of immunosuppressive agents on drug metabolism in rats." Thesis, Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008270.

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28

Hammann, Felix. "Prediction of transport, pharmacokinetics, and effect of drugs /." Basel : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8905.

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29

Ye, Yanping. "Designing New Drugs to Treat Cardiac Arrhythmia." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/638.

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Heart failure resulting from different forms of cardiomyopathy is defined as the inability of the heart to pump sufficient blood to meet the body's metabolic demands. It is a major disease burden worldwide and the statistics show that 50% of the people who have the heart failure will eventually die from sudden cardiac death (SCD) associated with an arrhythmia. The central cause of disability and SCD is because of ventricular arrhythmias. Genetic mutations and acquired modifications to RyR2, the calcium release channel from sarcoplasmic reticulum, can increase the pathologic SR Ca2+ leak during

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30

D, Fleming Anne H. "The effect of nutritional knowledge on nutritional intake in individuals with heart failure." Connect to this title online, 2004. http://hdl.handle.net/1811/182.

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Senior Honors Thesis (Nursing)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains 23 p.; also includes graphics Includes bibliographical references (p. 22-23 ). Available online via Ohio State University's Knowledge Bank.

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31

Clark, Sarah A. "A clinical chemistry-based epidemiological study of the main causes of myocardial infarction." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390475.

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32

Maharsy, Wael. "Enhancing Cardiomyocyte Survival in Drug Induced Cardiac Injury." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23384.

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Cardiotoxicity associated with many cancer drugs is a critical issue facing physicians these days and a huge hurdle that must be overcome for a side effects-free cancer therapy. Survival of cardiac myocytes is compromised upon the exposure to certain chemotherapeutic drugs. Unfortunately, the mechanisms implicated in cardiac toxicity and the pathways governing myocyte survival are poorly understood. The following thesis addresses the mechanisms underlying the cardiotoxicity of two anticancer drugs, doxorubicin (DOX) and Imatinib mesylate (Gleevec). Transcription factor GATA-4, has recently eme

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33

Economos, Demetri. "Regulation of intracellular free calcium in heart and vascular smooth muscle by drugs and hormones." Thèse, Université de Sherbrooke, 1992. http://hdl.handle.net/11143/12085.

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Résumé: La contraction du muscle excitable, comme le muscle cardiaque et le muscle lisse vasculaire, dépend surtout de l'entrée du Ca2+ à l'intérieur de la cellule (ou la libération du [Ca]i) via des canaux voltages dépendants (de type T ou L) ou des canaux opérés par récepteurs. Le but de cette étude est de vérifier si certaines hormones comme l'insuline, l'endotheline-1 et la bradykinine augmentent le [Ca]i des cellules cardiaques et vasculaires via la stimulation des canaux calciques par un mécanisme qui est indépendant de l'activation des récepteurs. De plus, on a étudié les effets d'un ag

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34

Hoa, Nguyen Khanh. "Assessment of anti-diabetic effect of Vietnamese herbal drugs /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-585-2/.

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35

Elliott-Pearce, Ruth Ann. "The effect of drugs on isolated detrusor muscle contraction." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34339.

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Detrusor instability is the commonest type of urinary incontinence in the elderly and is present in up to 50% of patients attending continence clinics. Treatment of this condition, aimed at reducing uncontrollable detrusor contractions, is at present unsatisfactory. For example, calcium antagonists are cliniclly disappointing and studies were carried out to investigate why they are ineffective. Rats were treated with nimodipine for 8 days or with a single dose. Treatment for 8 days had no effect on isolated detrasor contraction but a single dose reduced detrasor contractile response. It is pro

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36

Dalal, Suntanu. "Amphetamine drugs potentiate morphine analgesia in the formalin test." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55488.

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There has been a great deal of research investigating drug combinations which can increase analgesia. A number of studies have been conducted with one particular combination--opioids combined with the amphetamine drugs. Despite the existing literature, this combination is rarely used in clinical practice. One purpose of this thesis is to review the literature pertaining to the opioid-amphetamine combination. Another purpose of this thesis is to investigate whether dextroamphetamine sulfate ($ circler$Dexedrine) can potentiate morphine sulfate analgesia in rats in the formalin test (Experiment

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37

Hopmeyer, Joanne. "Effect of physiologic parameters on the quantification of mitral regurgitation using the flow convergence method." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/10969.

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38

Jaffray, Mariesha A. "The MEDMAN study : implementing change at the community pharmacy/general practice interface." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158336.

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Introduction Management of coronary heart disease (CHD), a major cause of mortality and morbidity in the UK, in primary care, remains sub-optimal. This work aimed to: evaluate impact of a community pharmacy-led intervention on appropriateness of treatment and quality of life of CHD patients; describe opinions and experiences of community pharmacists and GPs and use management of change literature as an explanatory framework for the findings. Methods The thesis comprises: two literature reviews (pharmacy-led interventions for CHD and NHS-based studies using change theories); an RCT evaluating t

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39

Lange, Jeremy David. "The effect of anti-malarial drugs on the pituitary gland." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238726.

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40

Figueiredo, João Daniel Amaral. "The effect of anticancer drugs prodiginines in PP1 in melanoma." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/6861.

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Mestrado em Biomedicina Molecular<br>Um dos principais mecanismos reguladores da função celular é a fosforilação de proteínas. É de focar que a fosforilação anormal de proteínas-chave pode estar associada a várias patologias, incluindo o cancro. Embora já existam muitos estudos sobre cinases no cancro, o conhecimento sobre as fosfatases que antagonizam a acção das cinases é muito menos. A PP1, uma das principais proteínas fosfatase de serina/treonina expressa em todas as células eucarióticas, está envolvida em vários processos celulares incluindo apoptosis e ciclo celular. Na realidade,

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41

Ngamratanapaiboon, Surachai. "Metabolomics investigations of the effect of drugs on mammalian cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/41178/.

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Cell-based metabolomics using LC-MS systemizes the study of the uniqueness of small-molecule metabolite (metabolomes) profiles in cellular processes. Cell-based metabolomics can potentially be used in many applications for the study of biological perturbation from stimulants in cellular pathways. The advantages of cell-based metabolomics include ease of control and interpretation when compared to the study of human subjects and animal models. Furthermore, this method can decrease some highly challenging problems that occur in genomics, transcriptomics and proteomics. Nowadays, cell culture in

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42

Hutton, Therese. "The effect of serum on the hypodynamic frog heart." Thesis, University of Central Lancashire, 1989. http://clok.uclan.ac.uk/21032/.

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An investigation was made of the effects of serum and serum fractions on the isolated spontaneously beating frog heart preparation. Initial experiments were performed to develop a sensitive bioassay preparation to test for inotropic agents in serum. The isolated spontaneously beating frog heart was found to be sensitive, reliable and responded consistently to serum and its components. During the development of the bioassay it was found that the heart became weak after prolonged perfusion. An investigation was then made to determine the mechanism underlying the development of the hypodynamic (w

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43

Pace, Diane Todd. "Effect of postmenopausal hormone replacement on heart rate variability." View the abstract Download the full-text PDF version, 1998. http://etd.utmem.edu/ABSTRACTS/1998-003-pace-index.html.

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Thesis (Ph.D)--University of Tennessee Health Science Center, 1998.<br>Title from title page screen (viewed on October 17 2008). Research advisor: Kay F. Engelhardt. Document formatted into pages (xi, 162 p. : ill.). Vita. Abstract. Includes bibliographical references (p.162).

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44

Hart, Matthew Thomas. "The Effects of Aerosol Drug Delivery on Airway Resistance through Heat-Moisutre Exchangers." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/rt_theses/4.

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Introduction: The use of heat moisture exchangers (HMEs) is becoming more popular with many institutions delivering aerosolized medications between the HME and the endotracheal tube of patients being mechanically ventilated. When HMEs become saturated resistance can increase which can cause changes that can lead to patient-ventilator dysnchrony, development of intrinsic PEEP, and weaning difficulty. The purpose of this study was to determine the effects of aerosol drug delivery on resistance through heat-moisture exchangers. Method: An in-vitro model to simulate exhaled heat and humidity from

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45

McCabe, Christopher. "The effects of drugs acting at endothelin receptors on the cardiac electrophysiology of normal and ischaemic rabbit hearts." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401508.

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46

Mauck, Rebecca A. "The effect of prior education on the learning effect associated with the six-minute walk test in patients with congestive heart failure." Virtual Press, 2003. http://liblink.bsu.edu/uhtbin/catkey/1260490.

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A learning effect has been shown to be present in the repeated performance of the six-minute walk test and contributes to the variability of walk distance up to the third walk test. The purpose of this study was to see if education about the performance of the walk test could minimize the learning effect. It was hypothesized that education about the learning effect would decrease the learning effect. There were a total of 18 subjects (5 female and 13 male) with a mean age of 63.7+12.1 years that completed three standardized six-minute walk tests. The subjects were randomly assigned to either a

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47

Ridgway, Andrea Janina. "Ultrasound doppler evaluation of mechanical aortic heart valves." Thesis, Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/10213.

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48

Ravaglia, Davide. "Modelling social behavior of Drosophila Melanogaster under the effect of drugs." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18747/.

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Questa tesi affronta il problema di studiare il comportamento cognitivo negli animali attraverso metodi di analisi statistica e modelli dinamici stocastici. Negli esperimenti analizzati sono stati utilizzati degli esemplari di Drosophila Melanogaster confinati in un'arena a quali sono state somministrate droghe diverse in diversi esperimenti; parte integrante dello studio riguarderà l'influenza di queste droghe. Lo scopo è esaminare il comportamento cognitivo degli animali attraverso l'analisi statistica degli incontri tra esemplari che possono avvenire sia per una situazione casuale che per

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Tory, Rita. "The study of the effect of immunosuppressive drugs on lipid metabolism." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/7593.

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Introduction: Lipid abnormalities including increased total cholesterol, triglycerides, and lowdensity lipoprotein-cholesterol have been frequently reported in renal transplantation and could be involved in the high frequency of cardiovascular disease in this population. Immunosuppressive therapy appears to be a main factor that influences the post-transplant lipid profile. Cyclosporine A (CsA), rapamycin (RAPA), tacrolimus (TAC) and mycophenolate mofetil (MMF) are commonly used immunosuppressant in solid organ transplant patients. Several of these immunosuppressive agents including CsA, RAPA

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Daley, Emma. "The effect of mitochondrial membranolytic drugs on brain tumours in vitro." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272349.

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