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Artigos de revistas sobre o tema "Heart Muscles Diseases"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 31 de janeiro de 2023

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1

Agafonov, F. D. "The state of the peripheral circulatory system in infectious diseases." Kazan medical journal 25, no. 11 (October 29, 2021): 1210–17. http://dx.doi.org/10.17816/kazmj80472.

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The state of blood circulation and the causes of its disorder, both in chronic and, in particular, in acute infectious diseases, have always been of great interest to both clinicians and pathologists. Since the time of Laennec, who first drew attention to the weakness of the heart muscles in those who died from febrile diseases and emphasized, like Louis, weakness and fragility of the heart muscle, they began to look for the causes of these disorders in the state of the heart muscles. A significant success in the study of diseases of the heart muscle in infectious diseases was the teaching of

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Chandragirish S, Harsha B R, and Girish V. Patil. "Morphometric study on papillary muscles of human tricuspid valve-dissection method." Indian Journal of Clinical Anatomy and Physiology 8, no. 3 (October 15, 2021): 190–93. http://dx.doi.org/10.18231/j.ijcap.2021.043.

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Aim of the present study was to observe the measurements of anterior papillary muscles present in tricuspid valve of human heart. Measurements of anterior papillary muscles in tricuspid valve gains utmost importance in cardiac surgeries because they are the causes of myocardial infarction in recent times because of its variations and detection of these causes by advent in modern technologies which will help in treatment of tricuspid valve diseases. This study was carried out on 96 normal formalin fixed human heart specimens. Dissection was performed according to standard techniques. Anterior p

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Gorkova, N. B., L. M. Starykh, and L. E. Karpova. "A case of early pelvic-brachial progressive muscular dystrophy with severe heart involvement." Kazan medical journal 72, no. 2 (February 15, 1991): 142–44. http://dx.doi.org/10.17816/kazmj106605.

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Progressive muscular dystrophies (PMD) are a group of hereditary diseases characterized by a primary dystrophic process in muscle tissue. The peculiarity and characteristics of cardiac disorders depend both on the nosological form with a characteristic muscle pathology for each of them, and on the stage, severity of the course of the disease and the mass of the affected muscles, and circulatory failure is less pronounced than damage to skeletal muscles.

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Jörgen Sandell and Mark Davies. "Benefits of sauna on lung capacity, neurocognitive diseases, and heart health." World Journal of Advanced Research and Reviews 17, no. 1 (January 30, 2023): 057–62. http://dx.doi.org/10.30574/wjarr.2023.17.1.1414.

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Sauna refers to passive heat therapy that involves exposure of the body to a high-temperature environment for an appropriately short period, contingent on the therapy’s purpose. Ideally, the therapy aims to raise the internal body temperature by a few degrees, and its effect happens in two phases. The first phase occurs during the first ten minutes, encouraging the body to perspire while maintaining a temperature of around 98.6 degrees. The extra heat is dispersed by increased blood circulation, blood pushing on the skin's surface, and sweating. The body enters the second phase after 10-30 min

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5

Nazir, Muhammad Mudasser, Muhammad Mazhar Ayaz, Atif Nisar Ahmed, Azhar Maqbool, Kamran Ashraf, Muhammad Oneeb, Ghulam Yasin, et al. "Prevalence of Toxoplasma gondii, Neospora caninum, and Sarcocystis Species DNA in the Heart and Breast Muscles of Rock Pigeons (Columbia livia)." Journal of Parasitology Research 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/6264042.

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Little is known about the prevalence of protozoan parasites in the muscles of rock pigeons (Columbia livia). The muscles from 54 (heart from 45 and breast from 54) rock pigeons were examined for DNA of Toxoplasma gondii, Neospora caninum, and Sarcocystis species using PCR. Twenty-four were female and 30 were males. The birds were part of flocks of pigeons housed at the tombs of saints in Lahore, Pakistan. Birds that died or were euthanized due to poor health were submitted for necropsy at the Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan, where DNA

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Shaikh, Rumana M. "Cardiovascular Diseases Prediction Using Machine Learning Algorithms." Turkish Journal of Computer and Mathematics Education (TURCOMAT) 12, no. 6 (April 11, 2021): 1083–88. http://dx.doi.org/10.17762/turcomat.v12i6.2426.

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A broad variety of health conditions are involved in heart disease. Several illnesses and disorders come under the heart disease umbrella. Heart disease forms include: In arrhythmia, abnormality of the heart rhythm. Arteriosclerosis, Hardening of the arteries is atherosclerosis. Via cardiomyopathy, this disorder causes muscles in the heart to harden or grow weak. Defects of the congenital heart, heart abnormalities that are present at birth are congenital heart defects. Disease of the coronary arteries (CAD), the accumulation of plaque in the heart's arteries triggers CAD. It's called ischemic

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7

Dubuisson, Nicolas, Romain Versele, María A. Davis-López de Carrizosa, Camille M. Selvais, Sonia M. Brichard, and Michel Abou-Samra. "Walking down Skeletal Muscle Lane: From Inflammasome to Disease." Cells 10, no. 11 (November 4, 2021): 3023. http://dx.doi.org/10.3390/cells10113023.

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Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in musc

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Caron, Marc-André, Richard Debigaré, P. N. Richard Dekhuijzen, and François Maltais. "Comparative assessment of the quadriceps and the diaphragm in patients with COPD." Journal of Applied Physiology 107, no. 3 (September 2009): 952–61. http://dx.doi.org/10.1152/japplphysiol.00194.2009.

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Chronic obstructive pulmonary disease (COPD) and other chronic diseases such as heart failure are accompanied by skeletal muscle alterations that further enhance morbidity and mortality in affected individuals. Several studies have highlighted important structural and biochemical modifications in limb and respiratory muscles in COPD. Reviewing the similarities and differences between the two most studied muscles in COPD, the quadriceps and the diaphragm, may be helpful in providing important clues about the mechanisms underlying muscle changes associated with this disease. Although oxidative s

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9

Kovalev, Dmitriy. "Myocarditis complicated by therapy-resistant heart failure." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 2 (February 1, 2020): 55–60. http://dx.doi.org/10.33920/med-10-2002-07.

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Myocarditis is an inflammation of the heart muscles, caused by direct or indirect — through immune mechanisms — exposure to infectious, physical and chemical factors, as well as developing in case of autoimmune diseases and heart transplantation. Inflammatory myocardial diseases are one of the rare nosological forms in cardiology, which, despite its nearly two-century history, still does not have clear guidelines for diagnosis and treatment.

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Moalla, Wassim, Grégory Dupont, Abdou Temfemo, Yves Maingourd, Matthew Weston, and Said Ahmaidi. "Assessment of exercise capacity and respiratory muscle oxygenation in healthy children and children with congenital heart diseases." Applied Physiology, Nutrition, and Metabolism 33, no. 3 (June 2008): 434–40. http://dx.doi.org/10.1139/h07-196.

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Muscular and cardiorespiratory dysfunction contributes to exercise intolerance. Therefore, the aim of the present study was to characterize the cardiopulmonary response andrespiratory muscle oxygenation of children with congenital heart diseases (CHD) when compared with those of healthy children. Twelve children with CHD in New York Heart Association (NYHA) class II or III, and 14 healthy children participated in the study. All subjects performed conventional spirographic measurements and a cardiopulmonary exercise test on a cycle ergometer. Oxygen uptake (VO2), carbon dioxide production (VCO2

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Musa, Ahmed, and Dheyauldeen Shabeeb. "Radiation-Induced Heart Diseases: Protective Effects of Natural Products." Medicina 55, no. 5 (May 9, 2019): 126. http://dx.doi.org/10.3390/medicina55050126.

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Cardiovascular diseases (CVDs) account for the majority of deaths worldwide. Radiation-induced heart diseases (RIHD) is one of the side effects following exposure to ionizing radiation (IR). Exposure could be from various forms such as diagnostic imaging, radiotherapy for cancer treatment, as well as nuclear disasters and nuclear accidents. RIHD is mostly observed after radiotherapy for thoracic malignancies, especially left breast cancer. RIHD may affect the supply of blood to heart muscles, leading to an increase in the risk of heart attacks to irradiated persons. Due to its dose-limiting co

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Skopenkova, Victoria V., Tatiana V. Egorova, and Maryana V. Bardina. "Muscle-Specific Promoters for Gene Therapy." Acta Naturae 13, no. 1 (March 15, 2021): 47–58. http://dx.doi.org/10.32607/actanaturae.11063.

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Many genetic diseases that are responsible for muscular disorders have been described to date. Gene replacement therapy is a state-of-the-art strategy used to treat such diseases. In this approach, the functional copy of a gene is delivered to the affected tissues using viral vectors. There is an urgent need for the design of short, regulatory sequences that would drive a high and robust expression of a therapeutic transgene in skeletal muscles, the diaphragm, and the heart, while exhibiting limited activity in non-target tissues. This review focuses on the development and improvement of muscl

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Ahmed, Dr Ahmed Mohammed, Abdullah Abdulkhaliq Qazzaz, and Dr Hydair Sachet Khalaf. "Ischemic Heart Disease Treatment." International Journal of Research in Science and Technology 12, no. 01 (2022): 39–41. http://dx.doi.org/10.37648/ijrst.v12i01.005.

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Ischemic heart disease IHD is a rapidly increasing common cause of death in the world. This disease is the insufficient status of oxygen within the cardiac muscles due to an imbalance between oxygen supply and demand, and a cardiac disease that occurs as a result of coronary artery stenosis. Ischemic heart disease diseases are the leading cause of death in both developed and developing countries ,among these IHD is the most prevalent manifestation and is associated with high mortality and morbidity. The clinical presentation of IHD include silent ischaemia, stable angina, unstable angina, myoc

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Naumova, Anna V., Gregory Kicska, Kiana Pimentel, Lauren E. Neidig, Hiroshi Tsuchida, Kenta Nakamura, and Charles E. Murry. "Quantitative Analyses of the Left Ventricle Volume and Cardiac Function in Normal and Infarcted Yucatan Minipigs." Journal of Imaging 7, no. 7 (July 1, 2021): 107. http://dx.doi.org/10.3390/jimaging7070107.

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(1) Background: The accuracy of the left ventricular volume (LVV) and contractility measurements with cardiac magnetic resonance imaging (CMRI) is decreased if the papillary muscles are abnormally enlarged, such as in hypertrophic cardiomyopathy in human patients or in pig models of human diseases. The purpose of this work was to establish the best method of LVV quantification with CMRI in pigs. (2) Methods: The LVV in 29 Yucatan minipig hearts was measured using two different techniques: the “standard method”, which uses smooth contouring along the endocardial surface and adds the papillary v

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15

Mujovic, Natasa, Nebojsa Mujovic, Vladimir Zugic, Ljubica Nikcevic, Milan Savic, and Mihailo Stjepanovic. "Rehabilitation treatment in diseases of the pulmonary interstitium." Medical review 66, suppl. 1 (2013): 72–76. http://dx.doi.org/10.2298/mpns13s1072m.

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Introduction. Patients with interstitial lung disease suffer from a wide range of persistent symptoms, such as fatigue, shortness of breath and general weakness. Discussion and Review of Literature. So far, there have scarcely been any specific nonpharmacological treatments to reduce the above mentioned symptoms in the treatment of these patients. However, it has been shown that physical exercise improves health status, exercise capacity, skeletal muscle function and reduces fatigue and dyspnea in patients with chronic lung and heart diseases. These symptoms significantly deteriorate the quali

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Rassier, Dilson E., and Anna Kashina. "Protein arginylation of cytoskeletal proteins in the muscle: modifications modifying function." American Journal of Physiology-Cell Physiology 316, no. 5 (May 1, 2019): C668—C677. http://dx.doi.org/10.1152/ajpcell.00500.2018.

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The cytoskeleton drives many essential processes in normal physiology, and its impairments underlie many diseases, including skeletal myopathies, cancer, and heart failure, that broadly affect developed countries worldwide. Cytoskeleton regulation is a field of investigation of rapidly emerging global importance and a new venue for the development of potential therapies. This review overviews our present understanding of the posttranslational regulation of the muscle cytoskeleton through arginylation, a tRNA-dependent addition of arginine to proteins mediated by arginyltransferase 1. We focus

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Christa, Martin, Stefanie Hahner, Herbert Köstler, Wolfgang Rudolf Bauer, Stefan Störk, and Andreas Max Weng. "Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study." European Journal of Endocrinology 186, no. 5 (May 1, 2022): K33—K38. http://dx.doi.org/10.1530/eje-22-0074.

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Background Sodium homeostasis is disrupted in many cardiovascular diseases, which makes non-invasive sodium storage assessment desirable. In this regard, sodium MRI has shown its potential to reveal differences in sodium content between healthy and diseased tissues as well as treatment-related changes of sodium content. When different tissues are affected disparately, simultaneous assessment of these compartments is expected to provide better information about sodium distribution, reduce examination time, and improve clinical efficiency. Objectives The objectives were (1) to investigate sodium

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Ciołkiewicz, Mariusz, Anna Kuryliszyn-Moskal, Anna Hryniewicz, and Karol Kamiński. "Sarcopenia and myokines profile as risk factors in cardiovascular diseases?" Postępy Higieny i Medycyny Doświadczalnej 73 (October 24, 2019): 550–62. http://dx.doi.org/10.5604/01.3001.0013.5442.

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Skeletal muscles and substances released during physical activity (myokines) have a beneficial influence on the functioning of the organism. Myokines (released also by myocardium) together with hepatokines and adipokines play an important role not only in energetic metabolism, but they also influence, among others, the function of the circulatory and nervous systems, modulation of inflammatory state and atherogenesis. Under pathological conditions connected with the presence of chronic diseases, chronic inflammatory state, low physical activity, long-term immobility the following consequences

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Moalla, Wassim, Mohamed Elloumi, Karim Chamari, Grégory Dupont, Yves Maingourd, Zouhair Tabka, and Said Ahmaidi. "Training effects on peripheral muscle oxygenation and performance in children with congenital heart diseases." Applied Physiology, Nutrition, and Metabolism 37, no. 4 (August 2012): 621–30. http://dx.doi.org/10.1139/h2012-036.

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We investigated the effect of training on peripheral muscular performance and oxygenation during exercise and recovery in children with congenital heart diseases (CHD). Eighteen patients with CHD aged 12 to 15 years were randomly assigned into either an individualized 12-week aerobic cycling training group (TG) or a control group (CG). Maximal voluntary contraction (MVC) and endurance at 50% MVC (time to exhaustion, Tlim) of the knee extensors were measured before and after training. During the 50% MVC exercise and recovery, near-infrared spectroscopy (NIRS) was used to assess the fall in musc

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Maimaiti, Rexiati, Chaoqun Zhu, Yanghai Zhang, Qiyue Ding, and Wei Guo. "RBM20-Mediated Pre-mRNA Splicing Has Muscle-Specificity and Differential Hormonal Responses between Muscles and in Muscle Cell Cultures." International Journal of Molecular Sciences 22, no. 6 (March 13, 2021): 2928. http://dx.doi.org/10.3390/ijms22062928.

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Pre-mRNA splicing plays an important role in muscle function and diseases. The RNA binding motif 20 (RBM20) is a splicing factor that is predominantly expressed in muscle tissues and primarily regulates pre-mRNA splicing of Ttn, encoding a giant muscle protein titin that is responsible for muscle function and diseases. RBM20-mediated Ttn splicing has been mostly studied in heart muscle, but not in skeletal muscle. In this study, we investigated splicing specificity in different muscle types in Rbm20 knockout rats and hormonal effects on RBM20-mediated splicing both in cellulo and in vivo studi

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Esteves, Patrícia R., Karla P. C. Araújo, Carlos E. Ambrósio, Dulcinéa G. Teixeira, Daniele S. Martins, Adriana C. Morini, João C. Morini Junior, et al. "Study of the cardiac left atrioventricular valvar complex in water buffaloes (Bubalus bubalis) of the Jafarabadi breed." Pesquisa Veterinária Brasileira 29, no. 10 (October 2009): 852–58. http://dx.doi.org/10.1590/s0100-736x2009001000013.

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Atrioventricular valve complex of 30 Jafarabadi water buffaloes, adult males were studied in this research with no heart diseases. The animals were obtained from a slaughterhouse in Brazilian State of Parana. The hearts were opened at the third portion affording access to the valve complex. The complexes had its area, number and type of tendinous cords submitted to analysis. The results showed that the complex is composed by two cusps and four accessory cusps, two or three papillary muscles in which 10-25 tendinous cords fix on the cusps that face the ventricle wall. The total area of the comp

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Rauniyar, RK, U. Sharma, and S. Baboo. "Isolated Extra hepatic Hydatid Cyst of Para spinal Muscle - Unusual Presentation - a Case Report." Nepalese Journal of Radiology 2, no. 1 (October 23, 2012): 31–34. http://dx.doi.org/10.3126/njr.v2i1.6977.

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Hydatid disease (echinococcosis) commonly involves liver while other known extrahepatic sites of involvement are lung, heart, brain, kidney, bones, spleen, pancreas, adrenal and muscles.1-3 Ultrasonography (US) and computed tomography (CT) features are characteristic especially in hepatic disease and hence diagnosed easily, while isolated extrahepatic diseases are sometimes difficult to diagnose. Here, we present an interesting case of hydatid cyst in paraspinal muscle with unusual clinical and imaging features, but treated successfully inspite, initial diagnostic dilemma. Imaging features and

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Chou, Ting-Heng, Sarah Janse, Albert J. Sinusas, and Mitchel R. Stacy. "SPECT/CT imaging of lower extremity perfusion reserve: A non-invasive correlate to exercise tolerance and cardiovascular fitness in patients undergoing clinically indicated myocardial perfusion imaging." Journal of Nuclear Cardiology 27, no. 6 (January 14, 2020): 1923–33. http://dx.doi.org/10.1007/s12350-019-02019-w.

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Abstract Background Although exercise is often prescribed for the management of cardiovascular diseases, a non-invasive imaging approach that quantifies skeletal muscle physiology and correlates with patients’ functional capacity and cardiovascular fitness has been absent. Therefore, we evaluated the potential of lower extremity single photon emission computed tomography (SPECT)/CT perfusion imaging as a non-invasive correlate to exercise tolerance and cardiovascular fitness. Methods Patients (n = 31) undergoing SPECT/CT myocardial perfusion imaging underwent additional stress/rest SPECT/CT im

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Kandasamy, Thilagasundari, Sabarinath Chandrasekar, Manimekalai Pichaivel, Sudhakar Pachaiappan, Gayathiri Muthusamy, and Lalitha Sumathi. "A Review of Zebrafish as an Alternative Animal Model and Its Benefits over Other Animal Models in Various Disease Conditions." Saudi Journal of Biomedical Research 7, no. 12 (December 15, 2022): 355–59. http://dx.doi.org/10.36348/sjbr.2022.v07i12.005.

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The zebrafish (Danio rerio) model has been exponentially adopted because it is a small tropical freshwater fish with crucial genetic, anatomical, and physiological homology with humans. Therefore, zebrafish constitute an excellent experimental model for behavioral, genetic, and toxicological studies that unravel the mechanisms of various human diseases. The zebrafish is a vertebrate, as it shares many organs with humans, including the blood, muscles, kidneys, and eyes. Genome organization and the pathways involved in controlling signal transduction appear to be highly conserved between zebrafi

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Indumathy, D., and S. Sudha. "Delineation of Blood Vessels in Coronary Artery Region for Classification of Different Types of Plaques." Journal of Biomaterials and Tissue Engineering 10, no. 7 (July 1, 2020): 901–14. http://dx.doi.org/10.1166/jbt.2020.2307.

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Cardiac arrest in human arises owing to blood vessel diseases or heart defects. Blood vessel diseases result due to the blockage of blood in the heart vessels, which leads to pain in the heart. Heart defects occur because of damage in the cardiac muscles indicated by abnormal heart rhythms. Cardiovascular diseases cause mortality which could be avoided through the earlier detection of cardiovascular diseases. The major cause for cardiovascular diseases is cholesterol deposition inside the artery walls which later forms plaques that block the blood flow. Until now, plaques have been detected th

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Crippa, Stefania, Marco Cassano, Graziella Messina, Daniela Galli, Beatriz G. Galvez, Tomaz Curk, Claudia Altomare, et al. "miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors." Journal of Cell Biology 193, no. 7 (June 27, 2011): 1197–212. http://dx.doi.org/10.1083/jcb.201011099.

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Postnatal heart stem and progenitor cells are a potential therapeutic tool for cardiomyopathies, but little is known about the mechanisms that control cardiac differentiation. Recent work has highlighted an important role for microribonucleic acids (miRNAs) as regulators of cardiac and skeletal myogenesis. In this paper, we isolated cardiac progenitors from neonatal β-sarcoglycan (Sgcb)–null mouse hearts affected by dilated cardiomyopathy. Unexpectedly, Sgcb-null cardiac progenitors spontaneously differentiated into skeletal muscle fibers both in vitro and when transplanted into regenerating m

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Rodrigues, Gabriel Dias, and Pedro Paulo da Silva Soares. "Home-Based Resistance Training in Heart Diseases: Don't Stop the Music, your Muscles are still Listening." International Journal of Cardiovascular Sciences 34, no. 2 (2021): 157–58. http://dx.doi.org/10.36660/ijcs.20210034.

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Chen, Tsung-Hsien, Shan-Wen Liu, Mei-Ru Chen, Kuan-Hung Cho, Tzu-Yin Chen, Pao-Hsien Chu, Yu-Ying Kao, Ching-Han Hsu, and Kurt Ming-Chao Lin. "Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/539805.

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Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation of autoimmune, metabolic, and cardiovascular diseases. The role of HSP60 in pathogenesis of these diseases remains unclear, partly because of the lack of mouse models expressing HSP60. In this study we generated HSP60 conditional transgenic mice suitable for investigatingin vivoou

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V. Gaikwad, Vikas, Abasaheb B. Patil, and Madhuri V. Gaikwad. "Scaffolds for Drug Delivery in Tissue Engineering." International Journal of Pharmaceutical Sciences and Nanotechnology 1, no. 2 (August 31, 2008): 113–23. http://dx.doi.org/10.37285/ijpsn.2008.1.2.1.

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Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth. Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. T

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Behera, Aruna K., Ethan Hildebrand, Roderick T. Bronson, George Perides, Satoshi Uematsu, Shizuo Akira, and Linden T. Hu. "MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi." Infection and Immunity 74, no. 3 (March 2006): 1462–70. http://dx.doi.org/10.1128/iai.74.3.1462-1470.2006.

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ABSTRACT Toll-like receptors (TLRs) play an important role in the control of infection with Borrelia burgdorferi. Deficiencies in TLR-2 or the shared TLR adapter molecule MyD88 have been shown to result in greatly increased bacterial burdens in mice. However, although in vitro studies have shown that the activation of TLR pathways by B. burgdorferi results in the release of inflammatory cytokines, studies in deficient mice have shown either no change or increased rather than decreased inflammation in infected animals. In this study, we looked at mechanisms to explain the increase in inflammati

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Ross, Colton J., Junnan Zheng, Liang Ma, Yi Wu, and Chung-Hao Lee. "Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review." Bioengineering 7, no. 1 (March 12, 2020): 25. http://dx.doi.org/10.3390/bioengineering7010025.

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The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers

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Nowak, Kristen J., Gianina Ravenscroft, Connie Jackaman, Aleksandra Filipovska, Stefan M. Davies, Esther M. Lim, Sarah E. Squire та ін. "Rescue of skeletal muscle α-actin–null mice by cardiac (fetal) α-actin". Journal of Cell Biology 185, № 5 (25 травня 2009): 903–15. http://dx.doi.org/10.1083/jcb.200812132.

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Skeletal muscle α-actin (ACTA1) is the major actin in postnatal skeletal muscle. Mutations of ACTA1 cause mostly fatal congenital myopathies. Cardiac α-actin (ACTC) is the major striated actin in adult heart and fetal skeletal muscle. It is unknown why ACTC and ACTA1 expression switch during development. We investigated whether ACTC can replace ACTA1 in postnatal skeletal muscle. Two ACTC transgenic mouse lines were crossed with Acta1 knockout mice (which all die by 9 d after birth). Offspring resulting from the cross with the high expressing line survive to old age, and their skeletal muscles

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Hinkle, Emma R., Hannah J. Wiedner, Eduardo V. Torres, Micaela Jackson, Adam J. Black, R. Eric Blue, Sarah E. Harris, et al. "Alternative splicing regulation of membrane trafficking genes during myogenesis." RNA 28, no. 4 (January 26, 2022): 523–40. http://dx.doi.org/10.1261/rna.078993.121.

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Alternative splicing transitions occur during organ development, and, in numerous diseases, splicing programs revert to fetal isoform expression. We previously found that extensive splicing changes occur during postnatal mouse heart development in genes encoding proteins involved in vesicle-mediated trafficking. However, the regulatory mechanisms of this splicing-trafficking network are unknown. Here, we found that membrane trafficking genes are alternatively spliced in a tissue-specific manner, with striated muscles exhibiting the highest levels of alternative exon inclusion. Treatment of dif

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Lin, BL, S. Govindan, S. Sadayappan, L. Zhao, J. Xu, and R. Han. "ID: 77: FAST-SKELETAL MYOSIN BINDING PROTEIN-C REGULATES SKELETAL MUSCLE CALCIUM SENSITIVITY." Journal of Investigative Medicine 64, no. 4 (March 22, 2016): 917.1–917. http://dx.doi.org/10.1136/jim-2016-000120.13.

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Mutations in myosin binding protein-C (MyBP-C) cause both cardiac and skeletal muscle diseases, such as hypertrophic cardiomyopathy and distal arthrogryposis. There are three isoforms of MyBP-C: slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C, and cMyBP-C, respectively). These isoforms reside within the sarcomere, the functional unit of muscle contraction at the molecular level. However, the function of the three major MyBP-C isoforms remains unclear. The present study is the first to focus on the least characterized isoform, fsMyBP-C, which is expressed in fast- and mixed-type s

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Sarshar, Nazanin Tataei, and Mohammad Mirzaei. "Premature Ventricular Contraction Recognition Based on a Deep Learning Approach." Journal of Healthcare Engineering 2022 (March 26, 2022): 1–7. http://dx.doi.org/10.1155/2022/1450723.

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Electrocardiogram signal (ECG) is considered a significant biological signal employed to diagnose heart diseases. An ECG signal allows the demonstration of the cyclical contraction and relaxation of human heart muscles. This signal is a primary and noninvasive tool employed to recognize the actual life threat related to the heart. Abnormal ECG heartbeat and arrhythmia are the possible symptoms of severe heart diseases that can lead to death. Premature ventricular contraction (PVC) is one of the most common arrhythmias which begins from the lower chamber of the heart and can cause cardiac arres

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Goodman, Barbara E. "Channels active in the excitability of nerves and skeletal muscles across the neuromuscular junction: basic function and pathophysiology." Advances in Physiology Education 32, no. 2 (June 2008): 127–35. http://dx.doi.org/10.1152/advan.00091.2007.

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Ion channels are essential for the basic physiological function of excitable cells such as nerve, skeletal, cardiac, and smooth muscle cells. Mutations in genes that encode ion channels have been identified to cause various diseases and disorders known as channelopathies. An understanding of how individual ion channels are involved in the activation of motoneurons and their corresponding muscle cells is essential for interpreting basic neurophysiology in nerves, the heart, and skeletal and smooth muscle. This review article is intended to clarify how channels work in nerves, neuromuscular junc

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Maria Celina Morales, M. d., and M. D. José Milei. "Immunoperoxidase technique in experimental chronic chagasic myocarditis." Revista do Instituto de Medicina Tropical de São Paulo 29, no. 2 (April 1987): 67–75. http://dx.doi.org/10.1590/s0036-46651987000200001.

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Chagas'disease has been described as the commonest form of chronic myocarditis. An immunologic pathogenesis has been discribed for this form of the disease. So far, no immunoperoxidase technique has been used for the detection of immunological deposits in chronic experimental Chagas'myocardiopathy. Forty-one Swiss mice, three months old were inoculated intraperitoneally with doses between 10 and 10(5) Tulahuen trypomastigotes. Mice were reinoculated one month after with doses between 10² and 10(5) and sacrificed at 6 (n=21) and 9 months (n=9) after the first inoculation. ECGs were recorded bef

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Garousi, F. "The essentiality of selenium for humans, animals, and plants, and the role of selenium in plant metabolism and physiology." Acta Universitatis Sapientiae, Alimentaria 10, no. 1 (October 1, 2017): 75–90. http://dx.doi.org/10.1515/ausal-2017-0005.

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AbstractAfter its discovery, selenium was most noted for its harmful effects. Selenium was the first element identified to occur in native vegetation at levels toxic to animals. Poisoning of animals can occur through consumption of plants containing toxic levels of selenium. Livestock consuming excessive amounts of selenized forages are afflicted with “alkali disease” and “blind staggers”. Typical symptoms of these diseases include loss of hair, deformed hooves, blindness, colic, diarrhoea, lethargy, increased heart and respiration rates, and eventually death. On the other hand, selenium defic

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Padula, Cynthia A., and Evelyn Yeaw. "Inspiratory Muscle Training: Integrative Review of Use in Conditions Other Than COPD." Research and Theory for Nursing Practice 21, no. 2 (June 2007): 98–118. http://dx.doi.org/10.1891/088971807780852039.

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Inspiratory muscle training (IM training) is a technique that is designed to improve the performance of the respiratory muscles (RMs) that may be impaired in a variety of conditions. Interest in IM training has expanded over the past two decades, and IM training has been used in an increasingly wide range of clinical conditions. However, the benefits of IM training continue to be debated, primarily because of methodological limitations of studies conducted to date. The focus of this article is to provide a critical review of IM training research in conditions other than chronic obstructive pul

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Vogt, Éverton Lopes, Maiza Cristina Von Dentz, Débora Santos Rocha, Jorge Felipe Argenta Model, Lucas Stahlhöfer Kowalewski, Samir Khal de Souza, Vitória de Oliveira Girelli, et al. "Metabolic and Molecular Subacute Effects of a Single Moderate-Intensity Exercise Bout, Performed in the Fasted State, in Obese Male Rats." International Journal of Environmental Research and Public Health 18, no. 14 (July 15, 2021): 7543. http://dx.doi.org/10.3390/ijerph18147543.

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Introduction and objectives: Obesity represents a major global public health problem. Its etiology is multifactorial and includes poor dietary habits, such as hypercaloric and hyperlipidic diets (HFDs), physical inactivity, and genetic factors. Regular exercise is, per se, a tool for the treatment and prevention of obesity, and recent studies suggest that the beneficial effects of exercise can be potentiated by the fasting state, thus potentially promoting additional effects. Despite the significant number of studies showing results that corroborate such hypothesis, very few have evaluated the

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Jong, Chian Ju, Priyanka Sandal, and Stephen W. Schaffer. "The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant." Molecules 26, no. 16 (August 13, 2021): 4913. http://dx.doi.org/10.3390/molecules26164913.

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Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first isolated in the 1800s, but not much was known about this molecule until the 1990s. In 1985, taurine was first approved as the treatment among heart failure patients in Japan. Accumulating studies have shown that taurine supplementation also protects against pathologies associated with mitochondrial defects, such as aging, mitochondrial diseases, metabolic syndrome, cancer, cardiovascular diseases and neurological

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Melnikov, V. P., and V. V. Pronin. "Heart and skeletal muscle inflammation – novel dangerous disease of farmed Salmonidae." Veterinary Science Today, no. 1 (March 30, 2020): 3–10. http://dx.doi.org/10.29326/2304-196x-2020-1-32-3-10.

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Heart and skeletal muscle inflammation (HSMI) is one of the most widespread economically relevant diseases of farmed Atlantic salmon (Salmo salar), and it poses serious danger to its aquaculture. The disease was first reported in Norway in 1999. In 2006, the Norwegian researchers demonstrated its viral etiology. Heart and skeletal muscle inflammation is a novel and understudied highly contagious transboundary disease of Salmonidae characterized by erythrocyte damage, blood circulation failure, jaundice and aggregated signs of heart and skeletal muscle inflammation. The disease associated econo

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Тymchik, Svitlana, Оleksandr Bryksin, and Eugenia Omelyanchuk. "Influence of different types of loads on the cardiovascular and muscular systems in the process of physical education classes in the department of athletic gymnastics." Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports), no. 5(136) (May 22, 2021): 128–32. http://dx.doi.org/10.31392/npu-nc.series15.2021.5(135).30.

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In the modern world with the advent of devices that facilitate work (computer, technical equipment) has decreased sharply motor activity of people compared to previous decades. This, in the end, leads to a decrease in human functionality, as well as various diseases. Today, purely physical work does not play a significant role, it is replaced by mental. Intellectual work dramatically reduces the efficiency of the body. Lack of human energy expenditure leads to inconsistencies in the functioning of individual systems (muscular, skeletal, respiratory, cardiovascular) and the body as a whole with

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Silva, Daniela N., Bruno S. F. Souza, Carine M. Azevedo, Juliana F. Vasconcelos, Paloma G. de Jesus, Malena S. Feitoza, Cassio S. Meira, et al. "IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease." Stem Cells International 2018 (July 24, 2018): 1–11. http://dx.doi.org/10.1155/2018/9108681.

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Mesenchymal stem/stromal cells (MSCs) have been investigated for the treatment of diseases that affect the cardiovascular system, including Chagas disease. MSCs are able to promote their beneficial actions through the secretion of proregenerative and immunomodulatory factors, including insulin-like growth factor-1 (IGF-1), which has proregenerative actions in the heart and skeletal muscle. Here, we evaluated the therapeutic potential of IGF-1-overexpressing MSCs (MSC_IGF-1) in a mouse model of chronic Chagas disease. C57BL/6 mice were infected with Colombian strain Trypanosoma cruzi and treate

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Hanafi, Noorul Izzati, Noor Hafizoh Saidan, Maizan Mohamed, KNS Sirajudeen, Siew Hua Gan, Khomaizon A. K. Pahirulzaman, and Rao Pasupuleti Visweswara. "REVIEW: ISCHEMIC HEART DISEASE AND THE POTENTIAL ROLE OF FENUGREEK (TRIGONELLA FOENUM GRAECUM LINN.) IN CARDIOPROTECTION." Jurnal Teknologi 84, no. 2 (February 23, 2022): 183–97. http://dx.doi.org/10.11113/jurnalteknologi.v84.17542.

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Ischemic heart disease, often known as coronary heart disease (CHD), is a term for heart disorders caused by narrowing heart arteries (coronary arteries) that provide blood to the heart's muscles. The body is prone to heart attacks when there is less oxygen supply (hypoxia) to the heart resulting a major cell death in the heart tissues. Cardiovascular disease (CVD) is the leading cause of death worldwide. Over the last few decades, the potential therapeutic effects of herbs and other types of complementary medicines for managing risk factors for CVD have gotten a lot of attention. Fenugreek (T

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Ramesh, Venkat, Vishnu R. Polati, P. Swathi Prakasham, Suneetha Narreddy, Ganta Saidulu, and Sneha Varahala. "An unusual case of tropical pyomyositis: cryptococcal pyomyositis." Tropical Doctor 50, no. 3 (June 2, 2020): 263–66. http://dx.doi.org/10.1177/0049475520927633.

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The more common manifestations of cryptococcal infections are restricted to the central nervous system and lungs. A young man, suffering from idiopathic dilated cardiomyopathy with a left ventricular ejection fraction of 20%, presented with subacute, painful tender swelling in both legs initially attributed to congestive cardiac failure. No response to diuretics was achieved. Metabolically active lesions in the muscles of both lower limbs suggestive of muscle abscesses were found. A diagnosis of tropical pyomyositis was therefore made, but aspiration surprisingly revealed gram-positive yeast c

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Taralov, Zdravko Z., Kiril V. Terziyski, and Stefan S. Kostianev. "Heart Rate Variability as a Method for Assessment of the Autonomic Nervous System and the Adaptations to Different Physiological and Pathological Conditions." Folia Medica 57, no. 3-4 (April 1, 2016): 173–80. http://dx.doi.org/10.1515/folmed-2015-0036.

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AbstractThe autonomic nervous system controls the smooth muscles of the internal organs, the cardiovascular system and the secretory function of the glands and plays a major role in the processes of adaptation. Heart rate variability is a non-invasive and easily applicable method for the assessment of its activity. The following review describes the origin, parameters and characteristics of this method and its potential for evaluation of the changes of the autonomic nervous system activity in different physiological and pathological conditions such as exogenous hypoxia, physical exercise and s

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Real, Eusebio, José Icardo, Gaspar Fernández-Barreras, José Revuelta, Marta Calvo Díez, Alejandro Pontón, José Gutiérrez, José López Higuera, and Olga Conde. "Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography." Sensors 19, no. 3 (January 28, 2019): 543. http://dx.doi.org/10.3390/s19030543.

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Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material. Disorder of the collagen structure due to different diseases (rheumatic, degenerative) implies the loss or reduction of tissue birefringence able to be characterized with Polarization Sensitive Optical Coherence Tomography (PS-OCT). PS-OCT is used to discriminate healthy from diseased chords, as the latte

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Christiansen, Liselotte B., Flemming Dela, Jørgen Koch, Christina N. Hansen, Pall S. Leifsson, and Takashi Yokota. "Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 10 (May 15, 2015): H1237—H1247. http://dx.doi.org/10.1152/ajpheart.00727.2014.

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Mitochondrial dysfunction and oxidative stress are important players in the development of various cardiovascular diseases, but their roles in hypertrophic cardiomyopathy (HCM) remain unknown. We examined whether mitochondrial oxidative phosphorylation (OXPHOS) capacity was impaired with enhanced mitochondrial oxidative stress in HCM. Cardiac and skeletal muscles were obtained from 9 domestic cats with spontaneously occurring HCM with preserved left ventricular systolic function and from 15 age-matched control cats. Mitochondrial OXPHOS capacities with nonfatty acid and fatty acid substrates i

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Raza, Hasnain, Touqeer Ahmad Raza, Faryal Batool, and Muhammad Umar Khallidoon. "Design of Dry and Long-Lasting Electrodes for ECG." Pakistan Journal of Engineering and Technology 4, no. 4 (December 16, 2021): 9–14. http://dx.doi.org/10.51846/vol4iss4pp9-14.

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Humans and animals both generate bioelectric signals through their tissues in static and active forms. These signals could be used to check the different physiological conditions of the body. Electrocardiogram (ECG) is one of the signals produced by the heart. ECG helps to monitor the health of the heart such as heart rate, contraction of heart muscles, and blood circulation. Abnormality in these parameters can cause serious cardiovascular diseases. Thus, monitoring of ECG helps to early diagnose cardiovascular diseases. To measure these signals electrodes or sensors are used. There are severa

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