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Artigos de revistas sobre o tema "Hematopoiesis"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

Sood, Raman, Milton English, Christiane Belele, et al. "Identification of Three Phases of Hematopoieisis in Zebrafish and Their Differential Requirements for Runx1 and Gata1 Functions." Blood 110, no. 11 (2007): 202. http://dx.doi.org/10.1182/blood.v110.11.202.202.

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Abstract Primitive hematopoiesis in the zebrafish takes place in the intermediate cell mass (ICM), while definitive hematopoiesis takes place in the kidney. Recently, a new transition site called caudal hematopoietic tissue (CHT), or posterior blood island (PBI) was identified. Using lineage tracing the hematopoietic cells originating from ICM were shown to transit through CHT and eventually populate kidney and thymus. However, the lineage relationship of the cells at these sites and the genetic control of early hematopoiesis in the zebrafish remain to be resolved. Transcription factors Gata1

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2

Wu, Jiang, Weiwei Zhang, Qian Ran, et al. "The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/1540148.

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Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. M

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Gerosa, Rahel C., Steffen Boettcher, Larisa V. Kovtonyuk, et al. "CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis." Blood Advances 5, no. 23 (2021): 5002–15. http://dx.doi.org/10.1182/bloodadvances.2021005531.

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Abstract Hematopoiesis is maintained by hematopoietic stem and progenitor cells that are located in the bone marrow (BM) where they are embedded within a complex supportive microenvironment consisting of a multitude of various non-hematopoietic and hematopoietic cell types. The BM microenvironment not only regulates steady-state hematopoiesis by provision of growth factors, cytokines, and cell–cell contact but is also an emerging key player during the adaptation to infectious and inflammatory insults (emergency hematopoiesis). Through a combination of gene expression analyses in prospectively

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4

Ozbudak, Irem H., Konstantin Shilo, Sabine Hale, Nadine S. Aguilera, Jeffrey R. Galvin, and Teri J. Franks. "Alveolar Airspace and Pulmonary Artery Involvement by Extramedullary Hematopoiesis: A Unique Manifestation of Myelofibrosis." Archives of Pathology & Laboratory Medicine 132, no. 1 (2008): 99–103. http://dx.doi.org/10.5858/2008-132-99-aaapai.

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Abstract Pulmonary extramedullary hematopoiesis is a rare manifestation of myelofibrosis. We encountered a unique case of pulmonary extramedullary hematopoiesis occurring in a 59-year-old white man, where in addition to the typical foci of interstitial hematopoietic cells, a surgical lung biopsy showed airspace and arterial wall involvement. Airspace foci were associated with acute and organizing alveolar hemorrhage, while within arteries the hematopoietic elements had a striking predilection for the vascular intima. The hematopoietic foci included erythroid precursors, myeloid precursors, and

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5

Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.bloodjournal8682876.

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The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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6

Smith, Clayton. "Hematopoietic Stem Cells and Hematopoiesis." Cancer Control 10, no. 1 (2003): 9–16. http://dx.doi.org/10.1177/107327480301000103.

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Background The highly orchestrated process of blood cell development and homeostasis is termed “hematopoiesis.” Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow transplants. Methods The author reviews the current state of the art regarding hematopoietic stem cells and hematopoiesis. Results Several new concepts, including stem cell plasticity, suggest the possibility that stem cells may have the ability to differe

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7

Wei, Chuijin, Pei Yu, and Lin Cheng. "Hematopoietic Reprogramming Entangles with Hematopoiesis." Trends in Cell Biology 30, no. 10 (2020): 752–63. http://dx.doi.org/10.1016/j.tcb.2020.07.006.

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8

Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.2876.

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Abstract The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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9

Testa, Ugo, Germana Castelli, and Elvira Pelosi. "CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC." Mediterranean Journal of Hematology and Infectious Diseases 14, no. 1 (2022): e2022069. http://dx.doi.org/10.4084/mjhid.2022.069.

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Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of clonal hematopoiesis. Clonal hematopoiesis of indeterminate potential (CHIP) is a term defining the clonal expansion of genetically variant hematopoietic cells bearing one or more gene mutations and/or structural variants (such as copy number alterations). CHIP increases exponentially with age and is associated with cancers, including hematolog

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10

Papa, Veronica, Luisa Marracino, Francesca Fortini, et al. "Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review." Journal of Clinical Medicine 9, no. 8 (2020): 2480. http://dx.doi.org/10.3390/jcm9082480.

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Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion of mutated clones of blood cells. This event is known as “clonal hematopoiesis.” Clonal hematopoiesis is closely associated with age, and carriers show an increased risk of developing blood cancers. Clonal hematopoiesis of indeterminate potential is defined by the presence of clones carrying a mutation associated with a blood neoplasm without obvious hematological malignancies. Unexpectedly, in recent years, it has emerged

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11

Fuchs, Anja G., Darlene Monlish, Sarbani Ghosh, et al. "Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF." Journal of Immunology 202, no. 1_Supplement (2019): 118.3. http://dx.doi.org/10.4049/jimmunol.202.supp.118.3.

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Abstract The acute inflammatory response to infection or injury dramatically increases the hematopoietic demand on the bone marrow to replace effector leukocytes consumed in the inflammatory response. In the setting of infection, pathogen-associated molecular patterns induce emergency hematopoiesis, activating hematopoietic stem and progenitor cells to proliferate, thereby providing progeny for accelerated myelopoiesis. Sterile tissue injury due to trauma also increases leukocyte demand; however, the effect of sterile tissue injury on hematopoiesis is not well described. We used a mouse model

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12

Matula, Zsolt, Gyöngyi Kudlik, Veronika Urbán S., and Ferenc Uher. "Quo vadis, hematológia?" Orvosi Hetilap 157, no. 46 (2016): 1819–29. http://dx.doi.org/10.1556/650.2016.30580.

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For decades, developing hematopoietic cells have been strictly compartmentalized into a small population of multipotent self-renewing hematopoietic stem cells, multipotent hematopoietic progenitor cells that are undergoing commitment to myeloid or lymphoid fates, and unipotent precursor cells that mature towards peripheral blood and immune cells. Recent studies, however, have provided a battery of findings that cannot be explained by this “classical” hierarchical model for the architecture of hematopoiesis. It is emerging that heterogeneous hematopoietic stem cell populations in the bone marro

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13

Ishigaki, Taro, Kazuhiro Sudo, Takashi Hiroyama, et al. "Human Hematopoietic Stem Cells Can Survive In Vitro for Several Months." Advances in Hematology 2009 (2009): 1–7. http://dx.doi.org/10.1155/2009/936761.

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We previously reported that long-lasting in vitro hematopoiesis could be achieved using the cells differentiated from primate embryonic stem (ES) cells. Thus, we speculated that hematopoietic stem cells differentiated from ES cells could sustain long-lasting in vitro hematopoiesis. To test this hypothesis, we investigated whether human hematopoietic stem cells could similarly sustain long-lasting in vitro hematopoiesis in the same culture system. Although the results varied between experiments, presumably due to differences in the quality of each hematopoietic stem cell sample, long-lasting in

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14

Sood, Raman, and Paul Liu. "Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models." Advances in Hematology 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/830703.

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Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However,

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15

Haney, Michael, Archana Shankar, Leonid Olender, et al. "Identification of the Saga Complex As a Key Regulator of Hematopoiesis." Blood 144, Supplement 1 (2024): 5623. https://doi.org/10.1182/blood-2024-205547.

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The hematopoietic system declines with age, and its dysfunction is associated with many diseases, ranging from infections to cancers. However, the processes that sustain lifelong hematopoiesis remain incompletely understood. To identify genetic regulators of hematopoiesis, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform. Targeting ~2000 genes with this platform, we identified SAGA complex members Tada2b and Taf5l as key regulators of hematopoiesis. Genetic perturbation of Tada2b or Taf5l in murine HSCs led to significant HSC expansion

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16

Arnold, Olivia, Theresa Bluemn, Cary Stelloh, Sridhar Rao, and Nan Zhu. "The SWI/SNF subunit ARID1B is important for regenerative ability of hematopoietic stem cells in normal hematopoiesis." PLOS ONE 19, no. 10 (2024): e0312616. http://dx.doi.org/10.1371/journal.pone.0312616.

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The Switch/Sugar non-fermenting (SWI/SNF) nucleosome remodeling complexes are essential for normal hematopoiesis. The Brg1/Brm associated factor (BAF) is a form of mammalian SWI/SNF that is distinguished by the presence of either ARID1A or ARID1B protein. In this study, we used hematopoietic specific Cre mouse models to assess the function of Arid1b in blood development. We found Arid1b loss did not affect steady state hematopoiesis or hematopoietic regeneration. Nonetheless, Arid1b null hematopoietic stem and progenitor cells have reduced ability to reconstitute hematopoietic system compared

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17

Belyavsky, Alexander, Nataliya Petinati, and Nina Drize. "Hematopoiesis during Ontogenesis, Adult Life, and Aging." International Journal of Molecular Sciences 22, no. 17 (2021): 9231. http://dx.doi.org/10.3390/ijms22179231.

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In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two stem cell types and their descendants interact. The descendants of HSCs supply the body with all the mature blood cells, while MSCs give rise to stromal cells that form a niche for HSCs and regulate the process of hematopoiesis. The studies of hematopoiesis were initially based on morphological observations, later extended by the use of physiological methods, and were subsequently augmented by massive application of sophi

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18

Sleptsov, A. A., M. S. Nazarenko, and V. Р. Puzyrev. "Common in atherogenesis and carcinogenesis: clonal hematopoiesis." Russian Journal of Cardiology 28, no. 10 (2023): 5511. http://dx.doi.org/10.15829/1560-4071-2023-5511.

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Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases. Clonal hematopoiesis in human ontogenesis occurs asymptomatically, and the fraction of mutant clones can exceed more than 2% of the total pool of circulating nucleated blood cells by age 70. Due to the variability of the accumulation rate of mutant clones, signs of clonal hematopoiesis can be observed at a younger age. Clonal hematopoiesis may act as a beni

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19

Drize, Nina, and Nataliya Petinati. "What do we know about the participation of hematopoietic stem cells in hematopoiesis?" F1000Research 4 (October 29, 2015): 1177. http://dx.doi.org/10.12688/f1000research.6459.1.

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The demonstrated presence in adult tissues of cells with sustained tissue regenerative potential has given rise to the concept of tissue stem cells. Assays to detect and measure such cells indicate that they have enormous proliferative potential and usually an ability to produce all or many of the mature cell types that define the specialized functionality of the tissue. In the hematopoietic system, one or only a few cells can restore lifelong hematopoiesis of the whole organism. To what extent is the maintenance of hematopoietic stem cells required during normal hematopoiesis? How does the co

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20

Link, Daniel C. "Clonal Evolution During Stress Hematopoiesis." Blood 130, Suppl_1 (2017): SCI—38—SCI—38. http://dx.doi.org/10.1182/blood.v130.suppl_1.sci-38.sci-38.

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Hematopoietic stem and progenitor cells (HSPCs) acquire somatic mutations with age resulting in a heterogeneous cell population, with each HSPC possessing its own unique set of private mutations. HSPCs that acquire somatic mutations that confer a competitive fitness advantage relative to their normal counterparts may clonally expand. Indeed, several groups have documented the presence of clonal hematopoiesis in healthy individuals. Although originally thought to be limited to older individuals, a recent study using an ultra-sensitive sequencing technique showed that expanded hematopoietic clon

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21

Yan, Hannah, Forrest C. Walker, Arushana Ali, et al. "The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling." Blood Advances 6, no. 6 (2022): 1754–65. http://dx.doi.org/10.1182/bloodadvances.2021006816.

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Abstract Antibiotic therapy, especially when administered long term, is associated with adverse hematologic effects such as cytopenia. Signals from the intestinal microbiota are critical to maintain normal hematopoiesis, and antibiotics can cause bone marrow suppression through depletion of the microbiota. We reported previously that STAT1 signaling is necessary for microbiota-dependent hematopoiesis, but the precise mechanisms by which the gut microbiota signals to the host bone marrow to regulate hematopoiesis remain undefined. We sought to identify the cell type(s) through which STAT1 promo

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22

Priestley, Gregory V., Linda M. Scott, Tatiana Ulyanova та Thalia Papayannopoulou. "Lack of α4 integrin expression in stem cells restricts competitive function and self-renewal activity". Blood 107, № 7 (2006): 2959–67. http://dx.doi.org/10.1182/blood-2005-07-2670.

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AbstractAlpha4 integrin or VLA4 (CD49d/CD29) is a multitask molecule with wide expression within and outside the hematopoietic system. Because targeted ablation of α4 integrin leads to embryonic lethality, to study its effects on adult hematopoiesis, we used animals with conditional excision of α4 integrin (α4Δ/Δ) in hematopoietic cells. In such animals, we previously documented weakened bone marrow retention of progenitor cells during homeostasis and impaired homing and short-term engraftment after transplantation. In the present study we show that long-term repopulating cells lacking α4 inte

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23

Ganuza, Miguel, Trent Hall, David Finkelstein, et al. "The global clonal complexity of the murine blood system declines throughout life and after serial transplantation." Blood 133, no. 18 (2019): 1927–42. http://dx.doi.org/10.1182/blood-2018-09-873059.

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Abstract Although many recent studies describe the emergence and prevalence of “clonal hematopoiesis of indeterminate potential” in aged human populations, a systematic analysis of the numbers of clones supporting steady-state hematopoiesis throughout mammalian life is lacking. Previous efforts relied on transplantation of “barcoded” hematopoietic stem cells (HSCs) to track the contribution of HSC clones to reconstituted blood. However, ex vivo manipulation and transplantation alter HSC function and thus may not reflect the biology of steady-state hematopoiesis. Using a noninvasive in vivo col

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24

Growney, Joseph D., Hirokazu Shigematsu, Zhe Li, et al. "Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype." Blood 104, no. 11 (2004): 227. http://dx.doi.org/10.1182/blood.v104.11.227.227.

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Abstract Homozygous loss of function of Runx1 during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription factors during development as opposed to adult hematopoiesis, we employed a conditional gene targeting strategy to effect loss of Runx1 function in adult mice. In contrast with the critical role of Runx1 during development, Runx1 was not essential for hematopoiesis in the adult hematopoietic compartment, although there were a number of si

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25

Growney, Joseph D., Hirokazu Shigematsu, Zhe Li, et al. "Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype." Blood 106, no. 2 (2005): 494–504. http://dx.doi.org/10.1182/blood-2004-08-3280.

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Abstract Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription factors during development as opposed to adult hematopoiesis, we used a conditional gene-targeting strategy to effect the loss of Runx1 function in adult mice. In contrast with the critical role of Runx1 during development, Runx1 was not essential for hematopoiesis in the adult hematopoietic comp

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26

Wan, Xiaoling, Lulu Liu, Peipei Zhou, et al. "The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo." Blood Advances 3, no. 4 (2019): 644–57. http://dx.doi.org/10.1182/bloodadvances.2018022756.

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Abstract Enhanced understanding of normal and malignant hematopoiesis pathways should facilitate the development of effective clinical treatment strategies for hematopoietic malignancies. Nuclear receptor corepressor 1 (NCoR1) has been implicated in transcriptional repression and embryonic organ development, but its role in hematopoiesis is yet to be fully elucidated. Here, we showed that hematopoietic-specific loss of NCoR1 leads to expansion of the hematopoietic stem cell (HSC) pool due to aberrant cell cycle entry of long-term HSCs under steady-state conditions. Moreover, NCoR1-deficient HS

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27

Shirin, A. D., R. Ya Vlasenko, N. Yu Anisimova, et al. "Hematopoietic stimulants in the treatment and prevention of graft-versus-host disease." Russian Journal of Pediatric Hematology and Oncology 9, no. 4 (2023): 64–74. http://dx.doi.org/10.21682/2311-1267-2022-9-4-64-74.

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Conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) are often accompanied by a period of aplasia characterized by severe neutropenia, anemia, and thrombocytopenia. Long-term antibacterial and immunosuppressive therapy in patients with graft-versus-host disease (GVHD) exacerbates hematopoietic depression. Colony-stimulating factors, erythropoietins, and thrombopoietin receptor agonists are used to correct hematological dysfunction in these patients. However, these drugs have side effects, and their stimulating effect, as a rule, is limited to one of the hematopoietic l

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Watt, Suzanne M., and Maria G. Roubelakis. "Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges." International Journal of Molecular Sciences 26, no. 2 (2025): 671. https://doi.org/10.3390/ijms26020671.

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Human hematopoietic stem cells (HSCs) have traditionally been viewed as self-renewing, multipotent cells with enormous potential in sustaining essential steady state blood and immune cell production throughout life. Indeed, around 86% (1011–1012) of new cells generated daily in a healthy young human adult are of hematopoietic origin. Therapeutically, human HSCs have contributed to over 1.5 million hematopoietic cell transplants (HCTs) globally, making this the most successful regenerative therapy to date. We will commence this review by briefly highlighting selected key achievements (from 1868

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Yao, Longbiao, Takafumi Yokota, Lijun Xia, Paul W. Kincade, and Rodger P. McEver. "Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells." Blood 106, no. 13 (2005): 4093–101. http://dx.doi.org/10.1182/blood-2005-02-0671.

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In vitro studies suggest that bone marrow endothelial cells contribute to multilineage hematopoiesis, but this function has not been studied in vivo. We used a Cre/loxP-mediated recombination to produce mice that lacked the cytokine receptor subunit gp130 in hematopoietic and endothelial cells. Although normal at birth, the mice developed bone marrow dysfunction that was accompanied by splenomegaly caused by extramedullary hematopoiesis. The hypocellular marrow contained myeloerythroid progenitors and functional repopulating stem cells. However, long-term bone marrow cultures produced few hema

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Lin, Hui-feng, Jing Zhang, and Robert I. Handin. "Morpholino Knockdown of Jak2a Inhibits Primitive and Definitive Hematopoiesis in Zebrafish." Blood 108, no. 11 (2006): 636. http://dx.doi.org/10.1182/blood.v108.11.636.636.

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Abstract In zebrafish, the primitive wave of hematopoiesis is specified at 3 somites and is marked by two lateral stripes, which express early hematopoietic genes. The coalescence of these stripes forms the intermediate cell mass (ICM). This phase of hematopoiesis lasts about 4 days with erythrocytes entering the circulation 26 hpf. Between 36 and 42 hpf, the definitive wave of hematopoiesis commences. It is marked by the presence of hematopoietic progenitor cells in the dorsal aortic wall. Later in day 3 of development, hematopoietic stem cells from the dorsal aorta migrate into the interstit

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Bolli, Niccolò, Elspeth M. Payne, Jennifer Rhodes, et al. "cpsf1 is required for definitive HSC survival in zebrafish." Blood 117, no. 15 (2011): 3996–4007. http://dx.doi.org/10.1182/blood-2010-08-304030.

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Abstract A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to bone marrow failure syndromes, myelodysplastic syndromes, and hematopoietic neoplasms. To identify novel genes involved in hematopoiesis, we performed an ethyl-nitrosourea mutagenesis screen in zebrafish (Danio rerio) to search for mutants with defective definitive hematopoiesis. We report the recovery and analysis of the grechetto mutant, which harbors an inactivating mutation in cleavage and polyadenylation specificity factor 1 (cpsf1), a gene ubiquitously

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Canu, Giovanni, and Christiana Ruhrberg. "First blood: the endothelial origins of hematopoietic progenitors." Angiogenesis 24, no. 2 (2021): 199–211. http://dx.doi.org/10.1007/s10456-021-09783-9.

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AbstractHematopoiesis in vertebrate embryos occurs in temporally and spatially overlapping waves in close proximity to blood vascular endothelial cells. Initially, yolk sac hematopoiesis produces primitive erythrocytes, megakaryocytes, and macrophages. Thereafter, sequential waves of definitive hematopoiesis arise from yolk sac and intraembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition (EHT). During EHT, the endothelial and hematopoietic transcriptional programs are tightly co-regulated to orchestrate a shift in cell identity. In the yolk sac, EHT generates eryt

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Jin, Hao, Jin Xu, and Zilong Wen. "Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development." Blood 109, no. 12 (2007): 5208–14. http://dx.doi.org/10.1182/blood-2007-01-069005.

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Abstract The development of vertebrate definitive hematopoiesis is featured by temporally and spatially dynamic distribution of hematopoietic stem/progenitor cells (HSPCs). It is proposed that the migration of definitive HSPCs, at least in part, accounts for this unique characteristic; however, compelling in vivo lineage evidence is still lacking. Here we present an in vivo analysis to delineate the migration route of definitive HSPCs in the early zebrafish embryo. Cell-marking analysis was able to first map definitive HSPCs to the ventral wall of dorsal aorta (DA). These cells were subsequent

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Lin, Kuan-Hung, Jui-Chung Chiang, Ya-Hsuan Ho, Chao-Ling Yao, and Hsinyu Lee. "Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling." International Journal of Molecular Sciences 21, no. 6 (2020): 2015. http://dx.doi.org/10.3390/ijms21062015.

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Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics have revealed the existence of numerous lipid molecules in hematopoietic microenvironment. Lysophosphatidic acid (LPA), a bioactive phospholipid molecule, is one of the identified lipids that participates in hematopoiesis. LPA exhibits various physiological functions through activation of G-protein-coupled receptors. The functions of these LPARs have been widely studie

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35

Lim, Hong Kiat, Pravin Periasamy, and Helen C. O’Neill. "In Vitro Murine Hematopoiesis Supported by Signaling from a Splenic Stromal Cell Line." Stem Cells International 2018 (December 25, 2018): 1–9. http://dx.doi.org/10.1155/2018/9896142.

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There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the differentiation of hematopoietic cells from progenitors in vitro. Initially, 5G3 was shown to express markers of mesenchymal but not endothelial or hematopoietic cells and to resemble perivascular reticular cells in the bone marrow through gene expression. In particular, 5G3 resembl

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Migliaccio, Anna Rita, Fabrizio Martelli, Maria Verrucci, et al. "Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation." Blood 114, no. 10 (2009): 2107–20. http://dx.doi.org/10.1182/blood-2009-03-211680.

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Abstract Rigorously defined reconstitution assays developed in recent years have allowed recognition of the delicate relationship that exists between hematopoietic stem cells and their niches. This balance ensures that hematopoiesis occurs in the marrow under steady-state conditions. However, during development, recovery from hematopoietic stress and in myeloproliferative disorders, hematopoiesis occurs in extramedullary sites whose microenvironments are still poorly defined. The hypomorphic Gata1low mutation deletes the regulatory sequences of the gene necessary for its expression in hematopo

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Kashlakova, A. I., B. V. Biderman, and E. N. Parovichnikova. "Clonal hematopoiesis and acute myeloid leukemia." Oncohematology 18, no. 3 (2023): 92–101. http://dx.doi.org/10.17650/1818-8346-2023-18-3-92-101.

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During aging phenotypic changes in the hematopoietic system occur, and possible reason of these changes can be accumulation of gene mutations in hematopoietic stem cells or early blood progenitors. Although these mutations are mostly neutral, some may give hematopoietic stem cells and progenitor cells a proliferative advantage. In this case clonal hematopoiesis will arise, which is characterized by the formation of a genetically distinct subpopulation of blood cells. Clonal hematopoiesis may become a basis for the development of hematologic malignancies, such as acute myeloid leukemia. Clonal

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Cousin, Béatrice, Louis Casteilla, Patrick Laharrague, Fabienne De Toni, and Sandrine Poglio. "Adipose tissues, hematopoietic cells and hematopoiesis." Hématologie 17, no. 1 (2011): 61–70. http://dx.doi.org/10.1684/hma.2011.0576.

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Shahidi, N. T. "Introduction: Hematopoiesis and Hematopoietic Growth Factors." Journal of Pediatric Hematology/Oncology 13, no. 4 (1991): 373–75. http://dx.doi.org/10.1097/00043426-199124000-00001.

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Grigorian, Melina, and Volker Hartenstein. "Hematopoiesis and hematopoietic organs in arthropods." Development Genes and Evolution 223, no. 1-2 (2013): 103–15. http://dx.doi.org/10.1007/s00427-012-0428-2.

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Yamane, Toshiyuki. "Cellular Basis of Embryonic Hematopoiesis and Its Implications in Prenatal Erythropoiesis." International Journal of Molecular Sciences 21, no. 24 (2020): 9346. http://dx.doi.org/10.3390/ijms21249346.

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Primitive erythrocytes are the first hematopoietic cells observed during ontogeny and are produced specifically in the yolk sac. Primitive erythrocytes express distinct hemoglobins compared with adult erythrocytes and circulate in the blood in the nucleated form. Hematopoietic stem cells produce adult-type (so-called definitive) erythrocytes. However, hematopoietic stem cells do not appear until the late embryonic/early fetal stage. Recent studies have shown that diverse types of hematopoietic progenitors are present in the yolk sac as well as primitive erythroblasts. Multipotent hematopoietic

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Kieusseian, Aurélie, Jalila Chagraoui, Cécile Kerdudo, et al. "Expression of Pitx2 in stromal cells is required for normal hematopoiesis." Blood 107, no. 2 (2006): 492–500. http://dx.doi.org/10.1182/blood-2005-02-0529.

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AbstractAlthough the expression of Pitx2, a bicoid family homeodomain transcription factor, is highly regulated during hematopoiesis, its function during this process was not documented; we thus studied hematopoiesis in Pitx2-null mice. We found that Pitx2–/– embryos display hypoplastic livers with reduced numbers of hematopoietic cells, but these cells had normal hematopoietic potential, as evidenced by colony-forming assays, immature progenitor cell assays, and long-term repopulation assays. Because the microenvironment is also crucial to the development of normal hematopoiesis, we establish

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Imamura, Masahiro. "Impaired Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation: Its Pathogenesis and Potential Treatments." Hemato 2, no. 1 (2021): 43–63. http://dx.doi.org/10.3390/hemato2010002.

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Impaired hematopoiesis is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Bone marrow aplasia and peripheral cytopenias arise from primary and secondary graft failure or primary and secondary poor graft function. Chimerism analysis is useful to discriminate these conditions. By determining the pathogenesis of impaired hematopoiesis, a timely and appropriate treatment can be performed. Hematopoietic system principally consists of hematopoietic stem cells and bone marrow microenvironment termed niches. Abnormality in hematopoietic stem and progenitor

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Zambidis, Elias T., Jihan Osborne, and Curt I. Civin. "Generation of a Common Progenitor Population from Human Embryonic Stem Cells That Gives Rise to Both Embryonic Erythropoiesis and Definitive Hematopoiesis." Blood 106, no. 11 (2005): 521. http://dx.doi.org/10.1182/blood.v106.11.521.521.

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Abstract Human embryonic stem cells (hESC) provide a valuable new tool for dissecting the earliest developmental events of human hematopoietic-stem progenitor cell (HSPC) genesis. We have recently reported the efficient step-wise differentiation of hESC to embryonic (primitive) erythroid cells followed by definitive erythro-myeloid hematopoietic cells from human embryoid bodies (hEB). Hematopoiesis proceeds spontaneously from hEB-derived cells and appears to model the earliest events of embryonic and definitive hematopoiesis in a manner resembling human yolk sac development. We now extend our

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Li, Xiang, Shunji Jia, Shaohe Wang, Yuemeng Wang, and Anming Meng. "Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos." Blood 114, no. 27 (2009): 5464–72. http://dx.doi.org/10.1182/blood-2009-06-227777.

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Abstract Metastasis-associated antigens 1/2/3 (Mta1/2/3) are components of nucleosome remodeling and deacetylase (NuRD) complexes and have been found to play roles in embryonic development and homeostasis. However, their functions in primitive hematopoiesis are unknown. In this study, we demonstrate that knockdown of mta3 by antisense morpholinos abolishes primitive hematopoietic lineages and causes abnormal angiogenesis in zebrafish embryos. However, the expression of the pronephric duct and paraxial mesoderm markers is unaltered and the specification of angioblasts is unaffected in mta3 morp

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Visnjic, Dora, Zana Kalajzic, David W. Rowe, Vedran Katavic, Joseph Lorenzo, and Hector L. Aguila. "Hematopoiesis is severely altered in mice with an induced osteoblast deficiency." Blood 103, no. 9 (2004): 3258–64. http://dx.doi.org/10.1182/blood-2003-11-4011.

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Abstract We previously reported a transgenic mouse model expressing herpesvirus thymidine kinase (TK) gene under the control of a 2.3-kilobase fragment of the rat collagen α1 type I promoter (Col2.3ΔTK). This construct confers lineage-specific expression in developing osteoblasts, allowing the conditional ablation of osteoblast lineage after treatment with ganciclovir (GCV). After GCV treatment these mice have profound alterations on bone formation leading to a progressive bone loss. In addition, treated animals also lose bone marrow cellularity. In this report we characterized hematopoietic p

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Petinati, N. A., and N. J. Drize. "Clonal hematopoiesis and its role in the development of hematological diseases." Russian journal of hematology and transfusiology 66, no. 4 (2021): 580–92. http://dx.doi.org/10.35754/0234-5730-2021-66-4-580-592.

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Introduction. The formation of blood cells in a healthy individual is ensured by polyclonal hematopoiesis. Recent studies have shown that with age, large clones with a common genetic marker are found in the peripheral blood, i. e. cells originating from a single progenitor cell. This phenomenon is called clonal hematopoiesis. In some cases, people with clonal hematopoiesis develop hematological diseases.Aim — to describe and summarize current data on the relationship between clonal hematopoiesis and hematological diseases.Main findings. This review describes the history of detection of clonal

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Fujita, Satoshi, Junya Toguchida, Yutaka Morita, and Hiroo Iwata. "Clonal Analysis of Hematopoiesis-Supporting Activity of Human Mesenchymal Stem Cells in Association with Jagged1 Expression and Osteogenic Potential." Cell Transplantation 17, no. 10-11 (2008): 1169–79. http://dx.doi.org/10.3727/096368908787236611.

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Human mesenchymal stem cells (hMSCs) are promising feeder cells for expanding hematopoietic stem cells (HSCs), but their potential is heterogeneous. We examined the hematopoiesis-supporting activity of hMSC at the clonal level in relation to the osteogenic potential and gene expression. Hematopoiesis-supporting activities of stably immortalized clonal hMSC lines were evaluated by the expansion of CD34+CD38- cells after 7-day coculture with human cord blood-derived CD34+ cells. Six of 16 clones expanded the numbers of CD34+CD38- cells >500-fold. These hematopoiesis-supportive clones also sho

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Tague, Laneshia, Karolyn A. Oetjen, Anirudh Mahadev, Daniel C. Link, and Andrew E. Gelman. "Increased Incidence of Clonal Hematopoiesis in Lung Transplant Recipients Involves DNA Damage Response Genes." Blood 138, Supplement 1 (2021): 2163. http://dx.doi.org/10.1182/blood-2021-150674.

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Abstract Lung transplant recipients receive lifelong immunosuppression that includes a calcineurin inhibitor (tacrolimus or cyclosporine), an anti-proliferative agent (mycophenolate or azathioprine) and corticosteroids. They are also known to be at increased risk for a broad spectrum of adverse hematologic events. This includes relatively common complications such as neutropenia and other cytopenias, which occur in over half of patients, as well as rarer events such as de novo hematopoietic malignancy. Certain patterns of clonal hematopoiesis, the expansion of unique somatic clones in hematopo

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Carvalho, Juliana França, Edson Marchiori, Gláucia Zanetti, et al. "Paravertebral Mass in a Patient with Hemolytic Anemia: Computed Tomographic Findings." Case Reports in Medicine 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/724279.

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Extramedullary hematopoiesis is characterized by the presence of hematopoietic tissue outside of the bone marrow and is typically associated with chronic hemolytic anemias. Intrathoracic extramedullary hematopoiesis is a rare and usually asymptomatic condition. The authors report a case of a 57-year-old man with intrathoracic extramedullary hematopoiesis and hereditary spherocytosis. Clinical and laboratory evaluation, together with radiological findings, are described. The diagnosis of the disease was confirmed by tissue biopsy.

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