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Artigos de revistas sobre o tema "Human Immunological aspects"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 2 de fevereiro de 2022

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1

Nyland, H., R. Matre, and S. Mörk. "Immunological aspects of human gliomas." Acta Neurologica Scandinavica 63, no. 2 (January 29, 2009): 141–42. http://dx.doi.org/10.1111/j.1600-0404.1981.tb00762.x.

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Uibo, Raivo, Andres Salumets, and Gilbert Faure. "Immunological Aspects of Human Reproduction." Clinical and Developmental Immunology 2012 (2012): 1–2. http://dx.doi.org/10.1155/2012/408329.

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Butterworth, A. E. "Immunological aspects of human schistosomiasis." British Medical Bulletin 54, no. 2 (January 1, 1998): 357–68. http://dx.doi.org/10.1093/oxfordjournals.bmb.a011693.

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4

Chandra, R. K. "Immunological Aspects of Human Milk." Nutrition Reviews 36, no. 9 (April 27, 2009): 265–72. http://dx.doi.org/10.1111/j.1753-4887.1978.tb07393.x.

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5

Karpati, George, and Montreal Myoblast Transfer Team. "Human myoblast transfer: Immunological aspects." Journal of Neuroimmunology 35 (January 1991): 65. http://dx.doi.org/10.1016/0165-5728(91)90955-7.

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6

ANDERSSON, ROLAND. "Immunological Aspects of Human Growth Hormone." Acta Paediatrica 75, s325 (April 1986): 48–54. http://dx.doi.org/10.1111/j.1651-2227.1986.tb10364.x.

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7

Hattori, N., and C. Inagaki. "Immunological aspects of human growth hormone and prolactin." Domestic Animal Endocrinology 15, no. 5 (September 1998): 371–75. http://dx.doi.org/10.1016/s0739-7240(98)00019-8.

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8

Mueller-Loebnitz, Christoph, Helmut Ostermann, Anke Franzke, Juergen Loeffler, Lutz Uharek, Max Topp, and Hermann Einsele. "Immunological Aspects ofCandidaandAspergillusSystemic Fungal Infections." Interdisciplinary Perspectives on Infectious Diseases 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/102934.

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Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells from TLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such

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9

Gergert, V. Ja, M. M. Averbakh, and A. E. Ergeshov. "Immunological aspects of tuberculosis pathogenesis." Terapevticheskii arkhiv 91, no. 11 (November 15, 2019): 90–97. http://dx.doi.org/10.26442/00403660.2019.11.000262.

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The morphological aspects of TB pathogenesis are well described in the publications. Much is also known about the main stages of development and formation of specific adaptive immunity. However, from our point of view, not enough attention is being paid to the involvement of the immune system in the pathogenesis of clinically relevant TB abnormalities, as well as various forms of the disease. Nevertheless, there is no doubt that the variety of clinical manifestations of any disease associated with the penetration of a foreign agent into the body, and Mycobacterium tuberculosis (MTB) in particu

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10

Andrews, R. B., C. D. R. Dunn, J. Jolly, J. B. Jones, and R. D. Lange. "Some Immunological and Haematological Aspects of Human Cyclic Neutropenia." Scandinavian Journal of Haematology 22, no. 2 (April 24, 2009): 97–104. http://dx.doi.org/10.1111/j.1600-0609.1979.tb00409.x.

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11

Gazzinelli, G., and Z. Brener. "Immunological aspects of the morbidity of human Chagas' disease." Research in Immunology 142, no. 2 (January 1991): 167–69. http://dx.doi.org/10.1016/0923-2494(91)90032-e.

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12

Hodgson, H. J. F. "Immunological aspects of inflammatory bowel diseases of the human gut." Agents and Actions 36, no. 3-4 (July 1992): C27—C31. http://dx.doi.org/10.1007/bf01996092.

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Hodgson, H. J. F. "Immunological aspects of inflammatory bowel diseases of the human gut." Agents and Actions 36, S1 (March 1992): C27—C31. http://dx.doi.org/10.1007/bf01991020.

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14

Torabinejad, Mahmoud, William C. Eby, and Irving J. Naidorf. "Inflammatory and immunological aspects of the pathogenesis of human periapical lesions." Journal of Endodontics 11, no. 11 (November 1985): 479–88. http://dx.doi.org/10.1016/s0099-2399(85)80221-1.

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15

VENCLÍKOVÁ, Zora, Oldrich BENADA, Jirina BÁRTOVÁ, Ludek JOSKA, and Lubor MRKLAS. "Metallic Pigmentation of Human Teeth and Gingiva: Morphological and Immunological Aspects." Dental Materials Journal 26, no. 1 (2007): 96–104. http://dx.doi.org/10.4012/dmj.26.96.

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16

Yan, Wei-Hua, Aifen Lin, Xue-Jiao Chen, Mei-Zhen Dai, Hui-Hui Xu, Bao-Guo Chen, Lin-Hong Gan, and Wei-Wu Shi. "Immunological aspects of human amniotic fluid cells: Implication for normal pregnancy." Cell Biology International 32, no. 1 (January 2008): 93–99. http://dx.doi.org/10.1016/j.cellbi.2007.08.017.

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Bocheva, Georgeta St, Radomir M. Slominski, and Andrzej T. Slominski. "Immunological Aspects of Skin Aging in Atopic Dermatitis." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5729. http://dx.doi.org/10.3390/ijms22115729.

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The cutaneous immune response is important for the regulation of skin aging well as for the development of immune-mediated skin diseases. Aging of the human skin undergoes immunosenescence with immunological alterations and can be affected by environmental stressors and internal factors, thus leading to various epidermal barrier abnormalities. The dysfunctional epidermal barrier, immune dysregulation, and skin dysbiosis in the advanced age, together with the genetic factors, facilitate the late onset of atopic dermatitis (AD) in the elderly, whose cases have recently been on the rise. Controve

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18

Luz, Jean Carlos dos Santos da, Fernanda Antunes, Maria Alejandra Clavijo-Salomon, Emanuela Signori, Nayara Gusmão Tessarollo, and Bryan E. Strauss. "Clinical Applications and Immunological Aspects of Electroporation-Based Therapies." Vaccines 9, no. 7 (July 2, 2021): 727. http://dx.doi.org/10.3390/vaccines9070727.

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Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunolo

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Zerpa, Olga, Marian Ulrich, Margarita Benitez, Concepción Ávila, Vestalia Rodríguez, Marta Centeno, Doris Belizario, Steven G. Reed, and Jacinto Convit. "Epidemiological and immunological aspects of human visceral leishmaniasis on Margarita Island, Venezuela." Memórias do Instituto Oswaldo Cruz 97, no. 8 (December 2002): 1079–83. http://dx.doi.org/10.1590/s0074-02762002000800002.

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Anversa, Laís, Monique Gomes Salles Tiburcio, Virgínia Bodelão Richini-Pereira, and Luis Eduardo Ramirez. "Human leishmaniasis in Brazil: A general review." Revista da Associação Médica Brasileira 64, no. 3 (March 2018): 281–89. http://dx.doi.org/10.1590/1806-9282.64.03.281.

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Summary Leishmaniasis is a disease with ample clinical spectrum and epidemiological diversity and is considered a major public health problem. This article presents an overview of the transmission cycles, host-parasite interactions, clinical, histological and immunological aspects, diagnosis and treatment of various forms of the human disease.

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Goodkin, Karl, Michael H. Antoni, Lynne Helder, and Bernd Sevin. "Psychoneuroimmunological Aspects of Disease Progression among Women with Human Papilloma Virus-Associated Cervical Dysplasia and Human Immunodeficiency Virus Type 1 Co-Infection." International Journal of Psychiatry in Medicine 23, no. 2 (June 1993): 119–48. http://dx.doi.org/10.2190/f8f0-4uk8-xv79-ec6g.

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Objective: Psychosocial associations have been observed with level of cervical dysplasia or “pre-cancer” and invasive cervical cancer [related to human papillomavirus (HPV) infection]. Psychoneuroimmunological relationships have been observed in human immunodeficiency virus type 1 (HIV-1) infection, which is being described in an increasing number of women. Our objective was to review these relationships regarding effects that might be expected in HIV-1 and HPV co-infected women. Method: This review was based on a Medline literature search supplemented by a manual search of selected journals u

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22

Nicolaisen, Else Marie, Lisbeth Lyng Hansen, Fritz Poulsen, Steven Glazer, and Ulla Hedner. "Immunological Aspects of Recombinant Factor Vila (rFVIIa) in Clinical Use." Thrombosis and Haemostasis 76, no. 02 (1996): 200–204. http://dx.doi.org/10.1055/s-0038-1650554.

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SummaryPatients, receiving rFVIIa for treatment of bleeding disorders, have been followed for specific antibody formation. No antibodies against FVII were demonstrated in 170 patients, with hemophilia, or with acquired inhibitors to clotting factors. Of 6 FVII-deficient patients, one overdosed patient developed antibodies to human FVII. There was no indication of de novo formation of antibodies to potential contaminating foreign protein, which could be correlated to the rFVIIa treatment. Except for the FVII-deficient population, which may represent a risk group, rFVIIa appears to be immunologi

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23

Montanari, Elisa, Carmen Gonelle‐Gispert, Jörg D. Seebach, Michael F. Knoll, Rita Bottino, and Leo H. Bühler. "Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human." Transplant International 32, no. 9 (May 15, 2019): 903–12. http://dx.doi.org/10.1111/tri.13445.

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24

Hamilton, R. G. "Human IgG subclass measurements in the clinical laboratory." Clinical Chemistry 33, no. 10 (October 1, 1987): 1707–25. http://dx.doi.org/10.1093/clinchem/33.10.1707.

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Abstract Complement activation, cell surface-receptor binding, blocking activity, and possibly placental transfer are among the biologically important functional differences that have been detected between the four human IgG subclasses by use of polyclonal antisera. In 1985, a IUIS/WHO panel of immunologists, using eight immunological methods, documented the specificity of select monoclonal antibodies for the IgG subclasses. Clinical assays have been developed involving these monoclonal antibodies that allow quantification of the concentration of IgG subclass protein and distribution of the Ig

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25

Deligeoroglou, Efthimios, Aikaterini Giannouli, Nikolaos Athanasopoulos, Vasileios Karountzos, Anastasia Vatopoulou, Konstantinos Dimopoulos, and George Creatsas. "HPV Infection: Immunological Aspects and Their Utility in Future Therapy." Infectious Diseases in Obstetrics and Gynecology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/540850.

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High prevalence and mortality rates of cervical cancer create an imperative need to clarify the uniqueness of HPV (Human Papillomavirus) infection, which serves as the key causative factor in cervical malignancies. Understanding the immunological details and the microenvironment of the infection can be a useful tool for the development of novel therapeutic interventions. Chronic infection and progression to carcinogenesis are sustained by immortalization potential of HPV, evasion techniques, and alterations in the microenvironment of the lesion. Inside the lesion, Toll-like receptors expressio

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Pluhator, Michelle M., Alan BR Thomson, and Richard N. Fedorak. "Clinical Aspects of Trace Elements: Zinc in Human Nutrition – A Biochemical and Physiological Perspective." Canadian Journal of Gastroenterology 9, no. 5 (1995): 251–56. http://dx.doi.org/10.1155/1995/384176.

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The tremendous technological advances in trace element analysis seen in recent years have stimulated and facilitated research in a number of disciplines including microbiology, nutrition, agriculture, clinical medicine and, most recently, psychology. The importance of trace elements to human health is receiving greater attention as clinical cases of deficiency and toxicity are described. Zinc has been recognized as an essential trace element for humans since the early 1960s. It has been found to play a critical role in the physiological and biochemical well-being of humans. This review discuss

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27

Keller, Thomas, Andrea Schneider Cta, Richard Dirnhofer, Regula Jungo, and Wolfgang Meyer. "Fluorescence Polarization Immunoassay for the Detection of Drugs of Abuse in Human Whole Blood." Medicine, Science and the Law 40, no. 3 (July 2000): 258–62. http://dx.doi.org/10.1177/002580240004000312.

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Fluorescence polarization immunoassay (FPIA) is a technique which has been known for a number of years. Since the development of the fundamental principles of fluorescence polarization by Perrin in a series of papers beginning in 1926, immunological techniques using labelled reactants have gained an extraordinary importance in the field of medical research and in routine diagnosis. As one of the nonradioactive immunological techniques, FPIA has found broad application in clinical and forensic toxicology. The authors report a new method to quickly screen autopsy, police and hospital blood sampl

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Kilpatrick, D. C. "Immunological aspects of the potential role of dietary carbohydrates and lectins in human health." European Journal of Nutrition 38, no. 3 (July 9, 1999): 107–17. http://dx.doi.org/10.1007/s003940050051.

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Jensen, James B., and John A. Vande Waa. "Epidemiological and immunological aspects of human crisis form factor in falciparum malaria: Cell-mediated responses?" Veterinary Parasitology 29, no. 2-3 (September 1988): 171–77. http://dx.doi.org/10.1016/0304-4017(88)90124-0.

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30

Perumal, A. N. I., Y. I. N. S. Gunawardene, and R. S. Dassanayake. "Setaria digitata in advancing our knowledge of human lymphatic filariasis." Journal of Helminthology 90, no. 2 (April 30, 2015): 129–38. http://dx.doi.org/10.1017/s0022149x15000309.

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AbstractSetaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. Due to its close resemblance to Wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. This review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of S. digitata that have broadened our understanding towards the control and eradication of filarial diseases.

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Corrigan, Margaret, and Gideon M. Hirschfield. "Aspects of the Pathophysiology of Primary Biliary Cirrhosis." Digestive Diseases 33, Suppl. 2 (2015): 102–8. http://dx.doi.org/10.1159/000440755.

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Primary biliary cirrhosis is a classical autoimmune liver disease and is present in around 1 in 1,000 women over the age of 40. It has a number of diagnostic characteristics consistent with autoimmune liver injury, in particular, the high specificity of circulating anti-mitochondrial antibodies. Histologically, the disease is reflected as a granulomatous lymphocytic cholangitis that consequently leads to small bile duct loss and cholestasis. Progressive disease is characterised by the development of a biliary cirrhosis, with end-stage features of liver disease ultimately impacting patient outc

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Darlan, Dewi Masyithah, Muhammad Fakhrur Rozi, and Hemma Yulfi. "Overview of Immunological Responses and Immunomodulation Properties of Trichuris sp.: Prospects for Better Understanding Human Trichuriasis." Life 11, no. 3 (February 27, 2021): 188. http://dx.doi.org/10.3390/life11030188.

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Trichuris sp. infection has appeared as a pathological burden in the population, but the immunomodulation features could result in an opportunity to discover novel treatments for diseases with prominent inflammatory responses. Regarding the immunological aspects, the innate immune responses against Trichuris sp. are also responsible for determining subsequent immune responses, including the activation of innate lymphoid cell type 2 (ILC2s), and encouraging the immune cell polarization of the resistant host phenotype. Nevertheless, this parasite can establish a supportive niche for worm surviva

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Velavan, TP, and Olusola Ojurongbe. "Regulatory T Cells and Parasites." Journal of Biomedicine and Biotechnology 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/520940.

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Human host encounters a wide array of parasites; however, the crucial aspect is the failure of the host immune system to clear these parasites despite antigen recognition. In the recent past, a new immunological concept has emerged, which provides a framework to better understand several aspects of host susceptibility to parasitic infection. It is widely believed that parasites are able to modulate the magnitude of effector responses by inducing regulatory T cell (Tregs) population and several studies have investigated whether this cell population plays a role in balancing protective immunity

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34

Prieto Pozo, Alfonso Agustín, and Francisco Luis Daniel Salvador Sagüez. "HIV and SARS-CoV-2: points to consider to face this new pandemic." Medwave 20, no. 09 (October 31, 2020): e8049-e8049. http://dx.doi.org/10.5867/medwave.2020.09.8049.

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In December 2019, a new species of pneumonia-causing betacoronavirus was identified in Wuhan, China, which was later identified as SARS-CoV-2. This RNA virus presents certain similarities with other viruses of the same genetic material. It has been seen that infection by human immunodeficiency virus resembles the infection by SARS-CoV-2 in various aspects. In this comment, we present some of the virological, immunological, clinical, and pharmacological similarities between HIV and SARS-CoV-2, which could allow us to understand the immunopathogenesis of COVID-19 better, as well as make some dec

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35

Rodrigues-Silva, Rosângela, Hércules Moura, Cerusa Dreyer, and Luiz Rey. "Human pulmonary dirofilariasis: a review." Revista do Instituto de Medicina Tropical de São Paulo 37, no. 6 (December 1995): 523–30. http://dx.doi.org/10.1590/s0036-46651995000600009.

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The authors presented a detailed summary of the geographical distribution, clinical and pathological aspects of human pulmonary dirofilariasis. Although benign, this zoonosis, of which Dirofilaria immitis is the major etiological agent, represents a medical problem since it produces symptoms which may be confused with neoplasia and thus may subject patients to unnecessary thoracic surgery. Of 229 cases cited in the literature, only 17 were reported in Brazil, despite the existence of highly favorable conditions for the transmission of this infection in man. Thus it may well be that this parasi

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Neroev, V. V., L. A. Katargina, L. A. Kovaleva, G. I. Krichevskaya, N. V. Balatskaya, and I. G. Kulikova. "Central bacterial corneal ulcers of prolonged course. Immunological aspects and tactics of etiopathogenetic treatment." Russian Ophthalmological Journal 12, no. 1 (March 16, 2019): 43–49. http://dx.doi.org/10.21516/2072-0076-2019-12-1-43-49.

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Purpose: to describe the characteristic clinical signs and to study the causes of the development of an unfavorable prolonged course of bacterial corneal ulcers of central localization, and to improve treatment effectiveness. Material and methods. A total of 289 patients with central bacterial corneal ulcers were examined. Two types courses of bacterial corneal ulcer were distinguished: favorable (acute and subacute) and unfavorable (prolonged subacute and prolonged chronic forms). Blood (122 samples) and scrapings from corneal ulcers (110 samples) were examined in a nested polymerase chain re

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37

Davydov, A. I., D. V. Isakov, R. А. Chilova, V. A. Lebedev, and M. N. Shakhlamova. "Clinical and immunological rationale for comprehensive approach to prevention and treatment of cervical intraepithelial neoplasia associated with human papillomavirus." Voprosy ginekologii, akušerstva i perinatologii 20, no. 3 (2021): 161–68. http://dx.doi.org/10.20953/1726-1678-2021-3-161-168.

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A clinical and immunological analysis of the use of antiviral agent Inosine Pranobex (IP) as postoperative drug therapy in patients with cervical intraepithelial neoplasia (CIN) associated with human papillomavirus (HPV) is performed. It is known that IP has a high anti-relapse activity adapted to the mechanisms of HPV elimination (through the sequence of oncoproteins E5, E6 and E7, a decrease in the synthesis of interferons (IFNs) occurs and resistance of HPV-infected cells to IFN is formed). In this work, a number of statements justifying the priority of IP in the treatment of patients with

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Janz, Siegfried. "Waldenström Macroglobulinemia: Clinical and Immunological Aspects, Natural History, Cell of Origin, and Emerging Mouse Models." ISRN Hematology 2013 (September 9, 2013): 1–25. http://dx.doi.org/10.1155/2013/815325.

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Waldenström macroglobulinemia (WM) is a rare and currently incurable neoplasm of IgM-expressing B-lymphocytes that is characterized by the occurrence of a monoclonal IgM (mIgM) paraprotein in blood serum and the infiltration of the hematopoietic bone marrow with malignant lymphoplasmacytic cells. The symptoms of patients with WM can be attributed to the extent and tissue sites of tumor cell infiltration and the magnitude and immunological specificity of the paraprotein. WM presents fascinating clues on neoplastic B-cell development, including the recent discovery of a specific gain-of-function

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Gredmark, Sara, Tamara Tilburgs, and Cecilia Söderberg-Nauclér. "Human Cytomegalovirus Inhibits Cytokine-Induced Macrophage Differentiation." Journal of Virology 78, no. 19 (October 1, 2004): 10378–89. http://dx.doi.org/10.1128/jvi.78.19.10378-10389.2004.

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ABSTRACT Human cytomegalovirus (HCMV) infection in immunocompromised patients is associated with impaired immunological function. Blood monocytes, which differentiate into macrophage effector cells, are of central importance for immune reactivity. Here, we demonstrate that HCMV transiently blocks cytokine-induced differentiation of monocytes into functionally active phagocytic macrophages. In HCMV-treated cultures, the cells had classical macrophage markers but lacked the classical morphological appearance of macrophages and had impairments in migration and phagocytosis. Even at very low multi

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Slamanig, Stefan A., and Martijn A. Nolte. "The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology." Cells 10, no. 6 (June 15, 2021): 1508. http://dx.doi.org/10.3390/cells10061508.

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The bone marrow (BM) is key to protective immunological memory because it harbors a major fraction of the body’s plasma cells, memory CD4+ and memory CD8+ T-cells. Despite its paramount significance for the human immune system, many aspects of how the BM enables decade-long immunity against pathogens are still poorly understood. In this review, we discuss the relationship between BM survival niches and long-lasting humoral immunity, how intrinsic and extrinsic factors define memory cell longevity and show that the BM is also capable of adopting many responsibilities of a secondary lymphoid org

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Fomsgaard, Anders, and Margaret A. Liu. "The Key Role of Nucleic Acid Vaccines for One Health." Viruses 13, no. 2 (February 8, 2021): 258. http://dx.doi.org/10.3390/v13020258.

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The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way

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Ryczek, Natalia, Magdalena Hryhorowicz, Joanna Zeyland, Daniel Lipiński, and Ryszard Słomski. "CRISPR/Cas Technology in Pig-to-Human Xenotransplantation Research." International Journal of Molecular Sciences 22, no. 6 (March 21, 2021): 3196. http://dx.doi.org/10.3390/ijms22063196.

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CRISPR/Cas (clustered regularly interspaced short palindromic repeats linked to Cas nuclease) technology has revolutionized many aspects of genetic engineering research. Thanks to it, it became possible to study the functions and mechanisms of biology with greater precision, as well as to obtain genetically modified organisms, both prokaryotic and eukaryotic. The changes introduced by the CRISPR/Cas system are based on the repair paths of the single or double strand DNA breaks that cause insertions, deletions, or precise integrations of donor DNA. These changes are crucial for many fields of s

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Maeland, Johan A., Andreas Radtke, Randi V. Lyng, and Rooyen T. Mavenyengwa. "Novel Aspects of the Z and R3 Antigens of Streptococcus agalactiae Revealed by Immunological Testing." Clinical and Vaccine Immunology 20, no. 4 (February 13, 2013): 607–12. http://dx.doi.org/10.1128/cvi.00581-12.

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ABSTRACTGroup B streptococci (GBS) are important human and bovine pathogens which can be classified by a variety of phenotype- and gene-based techniques. The capsular polysaccharide and strain-variable, surface-anchored proteins are particularly important phenotypic markers. In an earlier study, a previously unrecognized protein antigen called Z was described. It was expressed by 27.2% of GBS strains from Zimbabwe, usually in combination with R3 protein expression. In this study, a putative Z-specific antiserum actually contained antibodies against two different antigens named Z1 and Z2; Z1 wa

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Lightner, Amy, Danny J. Schust, Yi-Bin A. Chen, and Breton F. Barrier. "The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface?" Clinical and Developmental Immunology 2008 (2008): 1–10. http://dx.doi.org/10.1155/2008/631920.

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Human pregnancy poses a fundamental immunological problem because the placenta and fetus are genetically different from the host mother. Classical transplantation theory has not provided a plausible solution to this problem. Study of naturally occurring allogeneic chimeras in the colonial marine invertebrate, Botryllus schlosseri, has yielded fresh insight into the primitive development of allorecognition, especially regarding the role of natural killer (NK) cells. Uterine NK cells have a unique phenotype that appears to parallel aspects of the NK-like cells in the allorecognition system of B.

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van der Putten, Carlos, Ester B. M. Remmerswaal, Matty L. Terpstra, Nelly D. van der Bom, Jesper Kers, Ineke J. M. ten Berge, Suzanne E. Geerlings, René A. W. van Lier, Frederike J. Bemelman, and Michiel C. van Aalderen. "CD8 and CD4 T Cell Populations in Human Kidneys." Cells 10, no. 2 (February 1, 2021): 288. http://dx.doi.org/10.3390/cells10020288.

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Background: At border sites, and in internal organs, tissue resident memory T cells (TRM) contribute to the immune barrier against pathogens like viruses, bacteria, fungi, and cancer. However, information on the presence and function of these cells in the human kidney is scant. In order to better understand the T cell-mediated immunological defense in this organ, we aimed to determine phenotypic and functional aspects of CD8 and CD4 T cells present in healthy and allograft kidney tissue. Methods: Using multichannel flow cytometry, we assessed the phenotype and function of T cells in healthy re

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Akiyama, Shin'ichi, Enyu Imai, and Shoichi Maruyama. "Immunology of membranous nephropathy." F1000Research 8 (May 24, 2019): 734. http://dx.doi.org/10.12688/f1000research.17589.1.

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Accounting for about 20 to 50% of cases of primary nephrotic syndrome, membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. A rat model created nearly 60 years ago to research the primary MN disorder, Heymann nephritis, has provided us with a plethora of important information. Recently, our knowledge about MN has dramatically progressed. Heymann nephritis and human MN are now known to share a high degree of similarity in pathogenesis. This review summarizes our current understanding of MN pathogenesis while focusing particularly on the immunological aspects.

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Nelson, Michelle H., Marshall A. Diven, Logan W. Huff, and Chrystal M. Paulos. "Harnessing the Microbiome to Enhance Cancer Immunotherapy." Journal of Immunology Research 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/368736.

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The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to

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Rossi, Giacomo, Michela Rossi, Claudia G. Vitali, Damiano Fortuna, Daniela Burroni, Laura Pancotto, Sonia Capecchi, et al. "A Conventional Beagle Dog Model for Acute and Chronic Infection with Helicobacter pylori." Infection and Immunity 67, no. 6 (June 1, 1999): 3112–20. http://dx.doi.org/10.1128/iai.67.6.3112-3120.1999.

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ABSTRACT Helicobacter pylori has been widely recognized as an important human pathogen responsible for chronic gastritis, peptic ulcers, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Little is known about the natural history of this infection since patients are usually recognized as having the infection only after years or decades of chronic disease. Several animal models ofH. pylori infection, including those with different species of rodents, nonhuman primates, and germ-free animals, have been developed. Here we describe a new animal model in which the clinical, path

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Talaat, Kawsar R., A. Louis Bourgeois, Robert W. Frenck, Wilbur H. Chen, Calman A. MacLennan, Mark S. Riddle, Akamol E. Suvarnapunya, Jessica L. Brubaker, Karen L. Kotloff, and Chad K. Porter. "Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies." Clinical Infectious Diseases 69, Supplement_8 (December 9, 2019): S580—S590. http://dx.doi.org/10.1093/cid/ciz892.

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Abstract Shigella causes morbidity and mortality worldwide, primarily affecting young children living in low-resource settings. It is also of great concern due to increasing antibiotic resistance, and is a priority organism for the World Health Organization. A Shigella vaccine would decrease the morbidity and mortality associated with shigellosis, improve child health, and decrease the need for antibiotics. Controlled human infection models (CHIMs) are useful tools in vaccine evaluation for early up- or down-selection of vaccine candidates and potentially useful in support of licensure. Over t

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Yasin, Sumaiya, Theophilus Bhatti, Muhammad Umer Farooqi, and Farrukh Mateen. "Immunologic aspect in diagnosis and treatment of SARS-COV-2 patients." Journal of Shifa Tameer-e-Millat University 3, no. 2 (December 23, 2020): 113–21. http://dx.doi.org/10.32593/jstmu/vol3.iss2.88.

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Recent worldwide outbreak of novel coronavirus disease (CoVID-19) has affected massive human population including Pakistan, and has caused a huge number of mortalities in few months. CoVID-19 is an infectious disease caused by a virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which is single stranded RNA enveloped beta coronavirus and affects lower respiratory tract. It transmits from human to human through respiratory droplets. It uses its S-protein to recognize ACE2 (Angiotensin Converting Enzyme-2) receptors in lung epithelial cells where it attaches and causes infection

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