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Artigos de revistas sobre o tema "Immune complex diseases Immunological aspects"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 1 de fevereiro de 2022

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1

Troshina, Ekaterina A., Maria A. Terekhova, and Ravida R. Akhmatova. "Immunological aspects of papillary thyroid cancer. What's new?" Clinical and experimental thyroidology 16, no. 4 (June 15, 2021): 14–18. http://dx.doi.org/10.14341/ket12695.

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Studying of the common links of pathogenesis of endocrine, autoimmune and oncological diseases is the area of interest of researchers from all countries of the world. Comprehension of artificially created mutual influences of molecular-genetic, immune factors that underlie the development and progression of endocrine tumors, primarily thyroid cancer, is important for creation and application of innovative treatment methods in oncoendocrinology.Today, the question of considering autoimmune diseases as a potential cause of oncological processes or on the contrary to consider them as protective c

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Podoprigora, Gennadiy Ignat'evich, Lyudmila Ivanovna Kafarskaya, Nikolay Alekseevich Baynov, and Andrey Nikolaevich Shkoporov. "Bacterial Translocation from Intestine: Microbiological, Immunological and Pathophysiological Aspects." Annals of the Russian academy of medical sciences 70, no. 6 (December 6, 2015): 640–50. http://dx.doi.org/10.15690/vramn564.

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Bacterial translocation (BT) is both pathology and physiology phenomenon. In healthy newborns it accompanies the process of establishing the autochthonous intestinal microbiota and the host microbiome. In immunodeficiency it can be an aethio-pathogenetic link and a manifestation of infection or septic complications. The host colonization resistance to exogenous microbic colonizers is provided by gastrointestinal microbiota in concert with complex constitutional and adaptive defense mechanisms. BT may be result of barrier dysfunction and self-purification mechanisms involving the host myeloid c

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Salmasi, J. M., A. N. Kazimirskii, I. V. Kukes, G. V. Poryadin, and D. I. Pozdnyakov. "Interferoncontaining drugs: clinical, pharmacological, and immunological points of their use for respiratory diseases treatment." Meditsinskiy sovet = Medical Council, no. 11 (August 12, 2021): 210–20. http://dx.doi.org/10.21518/2079-701x-2021-11-210-220.

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Nowadays pharmacological group classified by the ATX L03AX code as immunostimulants is demand among doctors of various specialties. The main area of application of such drugs is infectious respiratory viral processes, which are associated not only with the pathogenetic action of viruses, but also with a high risk of bacterial complications. Thus, the practitioner is faced with the task of preventing such complications and choosing an immunomodulatory drug with the most pronounced pharmacodynamic properties in this regard. In Russia, there are many drugs belonging to the group of immunomodulato

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Kusters, Johannes G., Arnoud H. M. van Vliet, and Ernst J. Kuipers. "Pathogenesis of Helicobacter pylori Infection." Clinical Microbiology Reviews 19, no. 3 (July 2006): 449–90. http://dx.doi.org/10.1128/cmr.00054-05.

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SUMMARY Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay betwe

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Khammissa, R. A. G., R. Chandran, A. Masilana, J. Lemmer, and L. Feller. "Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions." Journal of Immunology Research 2018 (June 10, 2018): 1–10. http://dx.doi.org/10.1155/2018/7645465.

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Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cells, the repertoire of the T cell receptors, and the cytokine

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Signorile, Anna, Anna Ferretta, Maddalena Ruggieri, Damiano Paolicelli, Paolo Lattanzio, Maria Trojano, and Domenico De Rasmo. "Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics." Antioxidants 10, no. 1 (December 28, 2020): 21. http://dx.doi.org/10.3390/antiox10010021.

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Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial d

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Campos-Valdez, Marina, Hugo C. Monroy-Ramírez, Juan Armendáriz-Borunda, and Laura V. Sánchez-Orozco. "Molecular Mechanisms during Hepatitis B Infection and the Effects of the Virus Variability." Viruses 13, no. 6 (June 18, 2021): 1167. http://dx.doi.org/10.3390/v13061167.

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The immunopathogenesis and molecular mechanisms involved during a hepatitis B virus (HBV) infection have made the approaches for research complex, especially concerning the patients’ responses in the course of the early acute stage. The study of molecular bases involved in the viral clearance or persistence of the infection is complicated due to the difficulty to detect patients at the most adequate points of the disease, especially in the time lapse between the onset of the infection and the viral emergence. Despite this, there is valuable data obtained from animal and in vitro models, which

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Alagawany, Mahmoud, Shaaban S. Elnesr, Mayada R. Farag, Mohamed E. Abd El-Hack, Asmaa F. Khafaga, Ayman E. Taha, Ruchi Tiwari, et al. "Use of Licorice (Glycyrrhiza glabra) Herb as a Feed Additive in Poultry: Current Knowledge and Prospects." Animals 9, no. 8 (August 7, 2019): 536. http://dx.doi.org/10.3390/ani9080536.

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Supplementation of livestock and poultry diets with herbal plants containing bioactive components have shown promising reports as natural feed supplements. These additives are able to promote growth performance and improve feed efficiency, nutrient digestion, antioxidant status, immunological indices, and poultry health. Several studies have used complex herbal formulas with the partial inclusion of licorice. However, the individual use of licorice has been rarely reported. The major problem of the poultry industry is the epidemiological diseases, mainly confined to the respiratory, digestive,

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Figueroa, J. E., and P. Densen. "Infectious diseases associated with complement deficiencies." Clinical Microbiology Reviews 4, no. 3 (July 1991): 359–95. http://dx.doi.org/10.1128/cmr.4.3.359.

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The complement system consists of both plasma and membrane proteins. The former influence the inflammatory response, immune modulation, and host defense. The latter are complement receptors, which mediate the cellular effects of complement activation, and regulatory proteins, which protect host cells from complement-mediated injury. Complement activation occurs via either the classical or the alternative pathway, which converge at the level of C3 and share a sequence of terminal components. Four aspects of the complement cascade are critical to its function and regulation: (i) activation of th

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Amend, Anaïs, Natalie Wickli, Anna-Lena Schäfer, Dalina T. L. Sprenger, Rudolf A. Manz, Reinhard E. Voll, and Nina Chevalier. "Dual Role of Interleukin-10 in Murine NZB/W F1 Lupus." International Journal of Molecular Sciences 22, no. 3 (January 29, 2021): 1347. http://dx.doi.org/10.3390/ijms22031347.

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As a key anti-inflammatory cytokine, IL-10 is crucial in preventing inflammatory and autoimmune diseases. However, in human and murine lupus, its role remains controversial. Our aim was to understand regulation and immunologic effects of IL-10 on different immune functions in the setting of lupus. This was explored in lupus-prone NZB/W F1 mice in vitro and vivo to understand IL-10 effects on individual immune cells as well as in the complex in vivo setting. We found pleiotropic IL-10 expression that largely increased with progressing lupus, while IL-10 receptor (IL-10R) levels remained relativ

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Cohen-Inbar, Or, and Menashe Zaaroor. "Immunological Aspects of Malignant Gliomas." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43, no. 4 (April 13, 2016): 494–502. http://dx.doi.org/10.1017/cjn.2016.34.

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AbstractGlioblastoma Multiforme (GBM) is the most common malignant primary brain neoplasm having a mean survival time of <24 months. This figure remains constant, despite significant progress in medical research and treatment. The lack of an efficient anti-tumor immune response and the micro-invasive nature of the glioma malignant cells have been explained by a multitude of immune-suppressive mechanisms, proven in different models. These immune-resistant capabilities of the tumor result in a complex interplay this tumor shares with the immune system. We present a short review on the immunol

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Mueller-Loebnitz, Christoph, Helmut Ostermann, Anke Franzke, Juergen Loeffler, Lutz Uharek, Max Topp, and Hermann Einsele. "Immunological Aspects ofCandidaandAspergillusSystemic Fungal Infections." Interdisciplinary Perspectives on Infectious Diseases 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/102934.

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Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells from TLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such

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Grogan, Laura F., Josephine E. Humphries, Jacques Robert, Chantal M. Lanctôt, Catherine J. Nock, David A. Newell, and Hamish I. McCallum. "Immunological Aspects of Chytridiomycosis." Journal of Fungi 6, no. 4 (October 19, 2020): 234. http://dx.doi.org/10.3390/jof6040234.

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Amphibians are currently the most threatened vertebrate class, with the disease chytridiomycosis being a major contributor to their global declines. Chytridiomycosis is a frequently fatal skin disease caused by the fungal pathogens Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). The severity and extent of the impact of the infection caused by these pathogens across modern Amphibia are unprecedented in the history of vertebrate infectious diseases. The immune system of amphibians is thought to be largely similar to that of other jawed vertebrates, such as mamma

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Evstropov, Vladimir, Galina Zelenkova, Sergei Tresnitskii, Anna Spirina, Pavel Bykadorov, Mikhael Yenin, Еkaterina Danileyko, and Alexey Ermakov. "Immunological aspects of inflammatory periodontal disease (analytical review)." E3S Web of Conferences 210 (2020): 06005. http://dx.doi.org/10.1051/e3sconf/202021006005.

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Clinical and immunological parallels in inflammatory periodontal diseases are considered taking into account some features of the functioning of general and local structures of the immune system in periodontitis of varying severity, chronic generalized periodontitis, aggressive periodontitis. In the analysis of immunopathogenesis of inflammatory periodontal diseases, an essential role is given to an imbalance in the immune and cytokine system.

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Karpenko, S. F., Kh M. Galimzyanov, N. B. Kasimova, O. V. Rubalski, A. V. Kraskov, and O. N. Goryeva. "AGE ASPECTS OF THE CLINICAL AND IMMUNOLOGICAL MANIFESTATIONS OF COXIELLOSIS." Epidemiology and Infectious Diseases 17, no. 6 (December 15, 2012): 16–19. http://dx.doi.org/10.17816/eid40698.

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There are presented results of the clinical follow-up of 64 patients with moderate course of coxiellosis in whom the circulating immune complexes in the blood serum have been determined. All the patients received routine therapy, 29 patients were administered cycloferon intramuscularly, in dose of 2 ml, on the 1st, 2nd, 4th, 6th and 8th day of treatment. Clinical evidences of coxiellosis in the patients under routine treatment have been seen to be longer in the patients older than 50. Complex therapy with the use of cycloferon shortened the longevity of clinical evidences of the disease. By th

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Green-Johnson, Julia M. "Immunological Responses to Gut Bacteria." Journal of AOAC INTERNATIONAL 95, no. 1 (January 1, 2012): 35–49. http://dx.doi.org/10.5740/jaoacint.sge_green-johnson.

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Abstract The integral nature of interactions between the gut microbiota and host is especially evident with respect to effects on the immune system and host defenses. Host-microbiota interactions are increasingly being revealed as complex and dynamic, with far-reaching effects on varied aspects of host health. This review focuses on adaptive and innate immune responses to the gut microbiota and the bidirectional nature of these host-microbe interactions.

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Bocheva, Georgeta St, Radomir M. Slominski, and Andrzej T. Slominski. "Immunological Aspects of Skin Aging in Atopic Dermatitis." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5729. http://dx.doi.org/10.3390/ijms22115729.

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The cutaneous immune response is important for the regulation of skin aging well as for the development of immune-mediated skin diseases. Aging of the human skin undergoes immunosenescence with immunological alterations and can be affected by environmental stressors and internal factors, thus leading to various epidermal barrier abnormalities. The dysfunctional epidermal barrier, immune dysregulation, and skin dysbiosis in the advanced age, together with the genetic factors, facilitate the late onset of atopic dermatitis (AD) in the elderly, whose cases have recently been on the rise. Controve

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Berezhnova, Tatiyana A., Kseniya S. Dyadina, and Yana V. Kulintsova. "Immune-Metabolic Therapy of Purulent Inflammatory Diseases." Research Results in Pharmacology 6, no. 4 (October 12, 2020): 1–6. http://dx.doi.org/10.3897/rrpharmacology.6.55628.

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Introduction: Inflammatory diseases of the female genital organs rank among the leading ones in the total number of women of reproductive age. This results from a decrease in immunity, early sexual activity, neglect of personal hygiene, abortions, birth complications, etc. Materials and Methods: The study included 100 patients suffering from exacerbated chronic salpingo-oophoritis and its combination with bacterial vaginosis. In the study, all the patients were randomly divided into five groups, with 20 patients each. The patients were treated in the prescribed regimens and doses, according to

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Deligeoroglou, Efthimios, Aikaterini Giannouli, Nikolaos Athanasopoulos, Vasileios Karountzos, Anastasia Vatopoulou, Konstantinos Dimopoulos, and George Creatsas. "HPV Infection: Immunological Aspects and Their Utility in Future Therapy." Infectious Diseases in Obstetrics and Gynecology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/540850.

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High prevalence and mortality rates of cervical cancer create an imperative need to clarify the uniqueness of HPV (Human Papillomavirus) infection, which serves as the key causative factor in cervical malignancies. Understanding the immunological details and the microenvironment of the infection can be a useful tool for the development of novel therapeutic interventions. Chronic infection and progression to carcinogenesis are sustained by immortalization potential of HPV, evasion techniques, and alterations in the microenvironment of the lesion. Inside the lesion, Toll-like receptors expressio

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Attiyah, Sama M. N. "A Mini Review on Immune System and Immunological Diseases: Properties, Classification and Evolutional Aspects." Bioscience Biotechnology Research Communications 13, no. 4 (December 25, 2020): 1647–54. http://dx.doi.org/10.21786/bbrc/13.4/3.

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Silva, Camila Radelley Azevedo Costa da, Lisiane Vital de Oliveira, Lorenna Peixoto Lopes, Wancler Albert Gomes dos Santos, and Isabela Karine Rodrigues Agra. "Immunological aspects of coronavirus disease during pregnancy: an integrative review." Revista da Associação Médica Brasileira 66, no. 5 (May 2020): 696–700. http://dx.doi.org/10.1590/1806-9282.66.5.696.

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SUMMARY OBJECTIVE To review the immunological aspects of the 2019 coronavirus disease (COVID-19) in pregnancy, based on the scientific evidence currently available. METHODS An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed) and LILACS databases, using the descriptors “pregnancy” and “COVID-19”. This search included articles published up until 14th April 2020 published in English, Spanish or Portuguese. After reading the articles available in their entirety, those related specifically to the immunological aspects of

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Rolinski, Jacek, and Iwona Hus. "Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis." Journal of Immunology Research 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/513560.

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Herpes simplex keratitis (HSK) belongs to the major causes of visual morbidity worldwide and available methods of treatment remain unsatisfactory. Primary infection occurs usually early in life and is often asymptomatic. Chronic visual impairment and visual loss are caused by corneal scaring, thinning, and vascularization connected with recurrent HSV infections. The pathogenesis of herpetic keratitis is complex and is still not fully understood. According to the current knowledge, corneal scarring and vascularization are the result of chronic inflammatory reaction against HSV antigens. In this

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Darlan, Dewi Masyithah, Muhammad Fakhrur Rozi, and Hemma Yulfi. "Overview of Immunological Responses and Immunomodulation Properties of Trichuris sp.: Prospects for Better Understanding Human Trichuriasis." Life 11, no. 3 (February 27, 2021): 188. http://dx.doi.org/10.3390/life11030188.

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Trichuris sp. infection has appeared as a pathological burden in the population, but the immunomodulation features could result in an opportunity to discover novel treatments for diseases with prominent inflammatory responses. Regarding the immunological aspects, the innate immune responses against Trichuris sp. are also responsible for determining subsequent immune responses, including the activation of innate lymphoid cell type 2 (ILC2s), and encouraging the immune cell polarization of the resistant host phenotype. Nevertheless, this parasite can establish a supportive niche for worm surviva

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Longjam, Langamba Angom, and Dipmala Das. "Major histocompatibility complex and its importance towards controlling infection." Asian Journal of Medical Sciences 8, no. 2 (March 1, 2017): 1–13. http://dx.doi.org/10.3126/ajms.v8i2.16189.

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It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response during infection could be under genetic control. The Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) system is the most intensively studied of all genetic systems because of its influence to many important traits, including resistance to infectious diseases, autoimmunity and immunological self or nonself compatibility. T

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Pinching, Anthony J. "Clinical and immunological aspects of the acquired immune deficiency syndrome and related disorders." Journal of Hospital Infection 6 (December 1985): 1–8. http://dx.doi.org/10.1016/s0195-6701(85)80002-5.

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Gatto, Francesca, and Giuseppe Bardi. "Metallic Nanoparticles: General Research Approaches to Immunological Characterization." Nanomaterials 8, no. 10 (September 22, 2018): 753. http://dx.doi.org/10.3390/nano8100753.

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Our immunity is guaranteed by a complex system that includes specialized cells and active molecules working in a spatially and temporally coordinated manner. Interaction of nanomaterials with the immune system and their potential immunotoxicity are key aspects for an exhaustive biological characterization. Several assays can be used to unravel the immunological features of nanoparticles, each one giving information on specific pathways leading to immune activation or immune suppression. Size, shape, and surface chemistry determine the surrounding corona, mainly formed by soluble proteins, henc

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Abdel-Hakeem, Mohamed. "Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries." Viruses 11, no. 2 (January 27, 2019): 106. http://dx.doi.org/10.3390/v11020106.

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Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological breakthroughs originally identified with the help of the lymphocytic choriomeningitis virus (LCMV) model; immunological restriction by major histocompatibility complex and immunotherapy using checkpoint blockade. In addition, we discuss related discoveries such as development of tetramers, viral es

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Зиганшин, O. Ziganshin, Москвин, S. Moskvin, Гизингер, O. Gizinger, Шеметова, and M. Shemetova. "Immunological aspects of pathogenetic therapy of genital herpes by intravenous laser light of blood." Journal of New Medical Technologies. eJournal 9, no. 4 (December 8, 2015): 0. http://dx.doi.org/10.12737/16166.

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Chronic recurrent herpes virus infection of the genitals caused by the herpes virus type 2 is an inflammatory polyetiological disease, in the pathogenesis of which the reduction of non-specific resistance of the organism, an imbalance of immune factors plays an important role. Treatment of genital herpes infection should cover all the links of pathogenesis, including immunological. Clinical and immunological assessment of the effectiveness of intravenous laser light of blood in the UV spectral range (wavelength 365 nm, the device &#34;Lasmik- VLOK&#34;) wa

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Cortese, Laura, Giuseppe Terrazzano, and Alessandra Pelagalli. "Leptin and Immunological Profile in Obesity and Its Associated Diseases in Dogs." International Journal of Molecular Sciences 20, no. 10 (May 14, 2019): 2392. http://dx.doi.org/10.3390/ijms20102392.

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Growing scientific evidence has unveiled increased incidences of obesity in domestic animals and its influence on a plethora of associated disorders. Leptin, an adipokine regulating body fat mass, represents a key molecule in obesity, able to modulate immune responses and foster chronic inflammatory response in peripheral tissues. High levels of cytokines and inflammatory markers suggest an association between inflammatory state and obesity in dogs, highlighting the parallelism with humans. Canine obesity is a relevant disease always accompanied with several health conditions such as inflammat

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Srivastava, RN, and NS Verma. "Immunological Response to Post-trauma Bone Remodeling." Journal of Postgraduate Medicine, Education and Research 46, no. 3 (2012): 148–51. http://dx.doi.org/10.5005/jp-journals-10028-1033.

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ABSTRACT Bone-related immunology (osteoimmunology) is an interdisciplinary translational research field combining orthopaedics and immunology. This review gives an in-depth knowledge in the relationship between the bone trauma and the corresponding changes in host immune system. It also summarizes the most recent developments occuring into this complex field. It has been found that osteoblasts play important role in the maintenance of the hematopoietic stem cell niche and in lymphocyte development as well as the functions of immune cells participating in osteoblast and osteoclast development.

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Schmitt, Erica G., and Megan A. Cooper. "Genetics of Pediatric Immune-Mediated Diseases and Human Immunity." Annual Review of Immunology 39, no. 1 (April 26, 2021): 227–49. http://dx.doi.org/10.1146/annurev-immunol-093019-124513.

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Primary immunodeficiency diseases (PIDs) are a rapidly growing, heterogeneous group of genetically determined diseases characterized by defects in the immune system. While individually rare, collectively PIDs affect between 1/1,000 and 1/5,000 people worldwide. The clinical manifestations of PIDs vary from susceptibility to infections to autoimmunity and bone marrow failure. Our understanding of the human immune response has advanced by investigation and discovery of genetic mechanisms of PIDs. Studying patients with isolated genetic variants in proteins that participate in complex signaling p

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Kamath, Arati B., and Samuel M. Behar. "Anamnestic Responses of Mice following Mycobacterium tuberculosis Infection." Infection and Immunity 73, no. 9 (September 2005): 6110–18. http://dx.doi.org/10.1128/iai.73.9.6110-6118.2005.

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ABSTRACT The anamnestic response is the property of the immune system that makes vaccine development possible. Although the development of a vaccine against Mycobacterium tuberculosis is an important global priority, there are many gaps in our understanding of how immunological memory develops following M. tuberculosis infection or after BCG vaccination. In experiments designed to compare the anamnestic response of susceptible and resistant mouse strains, major histocompatibility complex-matched memory-immune C3.SW-H2b/SnJ and C57BL/6 mice both demonstrated better control of bacterial replicat

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Pagliari, Danilo, Giovanni Gambassi, Ciriaco A. Piccirillo, and Rossella Cianci. "The Intricate Link among Gut “Immunological Niche,” Microbiota, and Xenobiotics in Intestinal Pathology." Mediators of Inflammation 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8390595.

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Inflammatory bowel diseases (IBDs) are diseases characterized by various degrees of inflammation involving the gastrointestinal tract. Ulcerative colitis and Crohn’s disease are characterized by a dysregulated immune response leading to structural gut alterations in genetically predisposed individuals. Diverticular disease is characterized by abnormal immune response to normal gut microbiota. IBDs are linked to a lack of physiological tolerance of the mucosal immune system to resident gut microbiota and pathogens. The disruption of immune tolerance involves inflammatory pathways characterized

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Mastakov, Mihail Y., Kristin Baer, C. Wymond Symes, Claudia B. Leichtlein, Robert M. Kotin, and Matthew J. During. "Immunological Aspects of Recombinant Adeno-Associated Virus Delivery to the Mammalian Brain." Journal of Virology 76, no. 16 (August 15, 2002): 8446–54. http://dx.doi.org/10.1128/jvi.76.16.8446-8454.2002.

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ABSTRACT Recombinant adeno-associated viruses (rAAV) are highly efficient vectors for gene delivery into the central nervous system (CNS). However, host inflammatory and immune responses may play a critical role in limiting the use of rAAV vectors for gene therapy and functional genomic studies in vivo. Here, we evaluated the effect of repeated injections of five rAAV vectors expressing different genetic sequences (coding or noncoding) in a range of combinations into the rat brain. Specifically, we wished to determine whether a specific immune or inflammatory response appeared in response to t

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SALIKHOVA, T. R., N. S.-M. OMAROV, A. U. CHERKESOVA, S. M. GADJIMURADOVA, and E. R. ASKERKHANOVA. "CLINICO-MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL ASPECTS OF ENDOMETRIAL POLYP PATHOGENESIS IN POSTMENOPAUSE." Periódico Tchê Química 16, no. 32 (August 20, 2019): 724–31. http://dx.doi.org/10.52571/ptq.v16.n32.2019.742_periodico32_pgs_724_731.pdf.

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To study hypoxia-inducible transcription factor HIF-1α expression in endometrial polyps (EP) considering their clinical-morphological and immunological features during postmenopause. A complex clinical and laboratory examination of 120 postmenopausal patients was carried out. 90 of them developed EP, whereas 30 had morphologically unchanged endometrium. Immune histochemical (ICH) testing was used to evaluate HIF-1α expression in epithelial and stromal cells of polyps in adjacent and control endometrium. A complex of the most significant risk factors in EP genesis such as high rate of inflammat

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Wang, Hua, Wajahat Mehal, Laura E. Nagy, and Yaron Rotman. "Immunological mechanisms and therapeutic targets of fatty liver diseases." Cellular & Molecular Immunology 18, no. 1 (December 2, 2020): 73–91. http://dx.doi.org/10.1038/s41423-020-00579-3.

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AbstractAlcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major types of chronic liver disease worldwide. Inflammatory processes play key roles in the pathogeneses of fatty liver diseases, and continuous inflammation promotes the progression of alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). Although both ALD and NAFLD are closely related to inflammation, their respective developmental mechanisms differ to some extent. Here, we review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation

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Mizernitsky, Yu L., I. M. Melnikova, N. L. Dorovskaya, and V. I. Marushkov. "Immune and metabolic characteristics of children with recurrent respiratory diseases and efficacy of complex differentiated improving using seleksen and ascorbic acid." PULMONOLOGIYA, no. 4 (August 28, 2007): 46–50. http://dx.doi.org/10.18093/0869-0189-2007-0-4-46-50.

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This comparative clinical and immunological trial investigated clinical efficacy of Seleksen combined with ascorbic acid as a part of complex rehabilitation of children with recurrent respiratory diseases in sanatorium pre-school child care settings. We assessed serum levels of IgA, IgG, IgM, IgE, and interleukin-8, leucocyte luminol-induced chemiluminescence, secretory IgA level in saliva, erythrocyte glutathione peroxidase activity, serum superoxide dismutase activity, serum concentrations of malone dialdehyde and diene conjugates. The follow-up period was 12 months. The complex rehabilitati

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Dabelsteen, E. "Molecular Biological Aspects of Acquired Bullous Diseases." Critical Reviews in Oral Biology & Medicine 9, no. 2 (April 1998): 162–78. http://dx.doi.org/10.1177/10454411980090020201.

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Bullous diseases of the oral mucosa and skin were originally classified on the basis of clinical and histological criteria. The discovery of autoantibodies in some of these patients and the introduction of molecular biology have resulted in a new understanding of the pathological mechanisms of many of the bullous lesions. In this article, updated topics of the immune-mediated bullous lesions which involve oral mucosa and skin are reviewed. Pemphigus antigens, which are desmosomal-associated proteins and belong to the cadherin superfamily of cell adhesion proteins, have been isolated, and their

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KASHALA, OSCAR, KALAMBAYI KAYEMBE, PHYLLIS KANKI, PRUDENCE MUKEBA, MULAMBA DIESE, MBOWA KALENGAYI, KELA-WE IZZIA, and MAX ESSEX. "Humoral Aspects of Anti-HIV Immune Responses in Zairians with AIDS: Lower Antigenemia Does Not Correlate with Immune Complex Levels." AIDS Research and Human Retroviruses 9, no. 3 (March 1993): 251–58. http://dx.doi.org/10.1089/aid.1993.9.251.

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Zhang, Wenbao, Hao Wen, Jun Li, Renyong Lin, and Donald P. McManus. "Immunology and Immunodiagnosis of Cystic Echinococcosis: An Update." Clinical and Developmental Immunology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/101895.

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Cystic echinococcosis (CE) is a cosmopolitan zoonosis caused by the larval cystic stage of the dog tapewormEchinococcus granulosus. This complex multicellular pathogen produces various antigens which modulate the host immune response and promote parasite survival and development. The recent application of modern molecular and immunological approaches has revealed novel insights on the nature of the immune responses generated during the course of a hydatid infection, although many aspects of theEchinococcus-host interplay remain unexplored. This paper summarizes recent developments in our under

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Schreiner, G. F., and D. E. Kohan. "Regulation of renal transport processes and hemodynamics by macrophages and lymphocytes." American Journal of Physiology-Renal Physiology 258, no. 4 (April 1, 1990): F761—F767. http://dx.doi.org/10.1152/ajprenal.1990.258.4.f761.

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Inflammatory diseases of the renal glomerulus and interstitium are characterized by numerous alterations in renal glomerular hemodynamics and tubule transport processes. The cellular mechanisms underlying these changes have been theoretically attributed to nephron toxicity and destruction. However, recent studies suggest that many of the alterations in renal physiology may be mediated by specific immune cell-derived factors. Macrophages release a variety of cytokines on activation. One of these monokines, interleukin 1, induces a natriuresis by direct inhibition of collecting duct sodium reabs

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Pan, Shing Yi, Yvonne Cashinn Chia, Hui Rong Yee, Angelina Ying Fang Cheng, Clarice Evey Anjum, Yenny Kenisi, Mike KS Chan, and Michelle BF Wong. "Immunomodulatory potential of anti-idiotypic antibodies for the treatment of autoimmune diseases." Future Science OA 7, no. 2 (February 2021): FSO648. http://dx.doi.org/10.2144/fsoa-2020-0142.

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The immune system is a complex network of specialized cells and organs that recognises and reacts against foreign pathogens while remaining unresponsive to host tissues. This ability to self-tolerate is known as immunological tolerance. Autoimmune disease occurs when the immune system fails to differentiate between self and non-self antigens and releases autoantibodies to attack our own cells. Anti-idiotypic (anti-ID) antibodies are important in maintaining a balanced idiotypic regulatory network by neutralising and inhibiting the secretion of autoantibodies. Recently, anti-ID antibodies have

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Novellino, Fabiana, Valeria Saccà, Annalidia Donato, Paolo Zaffino, Maria Francesca Spadea, Marco Vismara, Biagio Arcidiacono, Natalia Malara, Ivan Presta, and Giuseppe Donato. "Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases." International Journal of Molecular Sciences 21, no. 3 (February 7, 2020): 1115. http://dx.doi.org/10.3390/ijms21031115.

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The intricate relationships between innate immunity and brain diseases raise increased interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders. Barriers, such as the blood–brain barrier, and innate immunity cells such as microglia, astrocytes, macrophages, and mast cells are involved in triggering disease events in these groups, through the action of many different cytokines. Chronic inflammation can lead to dysfunctions in large-scale brain networks. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic la

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Roth, Olivia, Monica Hongrø Solbakken, Ole Kristian Tørresen, Till Bayer, Michael Matschiner, Helle Tessand Baalsrud, Siv Nam Khang Hoff, et al. "Evolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes." Proceedings of the National Academy of Sciences 117, no. 17 (April 13, 2020): 9431–39. http://dx.doi.org/10.1073/pnas.1916251117.

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A fundamental problem for the evolution of pregnancy, the most specialized form of parental investment among vertebrates, is the rejection of the nonself-embryo. Mammals achieve immunological tolerance by down-regulating both major histocompatibility complex pathways (MHC I and II). Although pregnancy has evolved multiple times independently among vertebrates, knowledge of associated immune system adjustments is restricted to mammals. All of them (except monotremata) display full internal pregnancy, making evolutionary reconstructions within the class mammalia meaningless. Here, we study the s

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Bugorkova, S. A., T. N. Shchukovskaya, N. I. Mikishis, S. N. Klyueva, O. M. Kudryavtseva, A. L. Kravtsov, A. Yu Goncharova, et al. "Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia." Epidemiology and Vaccine Prevention 17, no. 3 (June 20, 2018): 38–50. http://dx.doi.org/10.31631/2073-3046-2018-17-3-38-50.

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Relevance. In 2005 International Health Regulations, the plague, is on the list of dangerous infectious diseases that can cause emergency situations of interstate importance. Even single cases of human plague are considered as the basis for carrying out preventive measures. The paper presents the results of immunological monitoring conducted on the territory of the Republic of Kalmykia in order to assess the immunological efficacy and safety of the plague live vaccine The paper presents the results of immunological monitoring in the territory of the Kalmyk Republic over the individuals vaccina

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Tandra, Nitin, Peipei Wu, Xinyuan Hu, Fei Mao, Wenrong Xu, and Hui Qian. "Extracellular Vesicles: A New Nano Tool for the Treatment of Inflammatory Bowel Diseases." Current Nanoscience 15, no. 6 (October 11, 2019): 589–95. http://dx.doi.org/10.2174/1573413715666190411141126.

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The intestinal tract is a complex and important physiological and immunological organ. Intestinal tract homeostasis requires a series of coordinated interactions involving gut microbiota, the crypt intestinal stem cells (ISC) and the surrounding niche, including the intestinal epithelial cells, endothelial cells, dendritic cells, and macrophages. The destruction of intestinal homeostasis leads to autoimmune diseases, such as inflammatory bowel disease (IBD). IBD is a non-specific, and remittent- relapsing inflammatory disorder of the gastrointestinal tract. There is no effective method to keep

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Blight, Joshua, Eduardo Alves, and Arturo Reyes-Sandoval. "Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention." Vaccines 7, no. 4 (December 3, 2019): 203. http://dx.doi.org/10.3390/vaccines7040203.

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Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limited efficacy and is able to enhance the disease in some cases. These failures have mainly been due to the complex pathology and lack of understanding of the correlates of protection for dengue virus (DENV) infection. With increasing data suggesting both a protective and detrimental effect for antibodies and CD8 T-cells whilst having complex environmental dynam

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Рогалев, K. Rogalev, Шишова, A. Shishova, Мартынова, N. Martynova, Басова, et al. "Mathematical modeling of immunological parameters for the prediction and diagnosis of chronic non-communicable diseases among health care workers." Journal of New Medical Technologies. eJournal 9, no. 4 (December 8, 2015): 0. http://dx.doi.org/10.12737/16163.

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This article presents a mathematical method of interpretation of immunological parameters of blood. The study used a comprehensive evaluation of the possibility of disease development, not only on the basis of qualitative data, directly gender-related characteristics and professional activities (occupation, profile, department, work with the equipment), but also quantitative data - age, work experience, immunological indicators of the level of immune protection of the subject. The analysis of multidimensional data allowed to identifying immunological symptoms as p

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Lecuit, Marc, Frank Martinez, Gilbert Deray, Hélène Beaufils, Marie‐Claire Gubler, Jean‐Pierre Nozais, François Bricaire, and Claude Jacobs. "Clinical and Pathophysiological Aspects of Immune Complex Glomerulonephritis Associated with Entamoeba histolytica Abscess of the Liver." Clinical Infectious Diseases 25, no. 2 (August 1997): 335–36. http://dx.doi.org/10.1086/516914.

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Lee, C. Y., K. A. Munyard, K. Gregg, J. D. Wetherall, M. J. Stear, and D. M. Groth. "The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep." Journal of Parasitology Research 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/101848.

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Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions betw

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