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Artigos de revistas sobre o tema "In vivo studies"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 11 de março de 2023

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1

Naveed, Safila, Najma Sultana e Muhammad Saeed Arayne. "In vivo and in vitro interaction studies of ibuprofen with enalapril". Journal of Coastal Life Medicine 4, n.º 4 (abril de 2016): 327–30. http://dx.doi.org/10.12980/jclm.4.2016j5-198.

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2

Sharma, Rakesh Kumar, e Anil Kumar Midda. "Preparation of Sustained Release Microspheres of Aceclofenac: Characterization & in-vivo studies". International Journal of Research and Development in Pharmacy & Life Sciences 6, n.º 7 (dezembro de 2017): 2862–66. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(7).2862-2866.

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3

Herbold, Bernd A., Susanne Y. Brendler-Schwaab e Hans Jürgen Ahr. "Ciprofloxacin: in vivo genotoxicity studies". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 498, n.º 1-2 (novembro de 2001): 193–205. http://dx.doi.org/10.1016/s1383-5718(01)00275-3.

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4

Su, Muh-Hwan, V. Srinivasan, Abdel-Halim Ghanem e William I. Higuchi. "Quantitative in Vivo Iontophoretic Studies". Journal of Pharmaceutical Sciences 83, n.º 1 (janeiro de 1994): 12–17. http://dx.doi.org/10.1002/jps.2600830105.

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5

Pomare, E. W., L. C. Hillman, S. Peters e A. Fisher. "In vivo studies with fibre components". Scandinavian Journal of Gastroenterology 22, sup129 (janeiro de 1987): 181–84. http://dx.doi.org/10.3109/00365528709095881.

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6

Booij, L. H. D. J., J. van Egmond, J. J. Driessen e H. D. de Boer. "In vivo animal studies with sugammadex". Anaesthesia 64 (março de 2009): 38–44. http://dx.doi.org/10.1111/j.1365-2044.2008.05869.x.

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7

Fahmy, Maha A., e Kawthar A. E. Diab. "In vivo Genotoxicity Studies of Cefotaxime". CYTOLOGIA 74, n.º 4 (2009): 417–25. http://dx.doi.org/10.1508/cytologia.74.417.

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8

Kaufman, Herbert E. "IN VIVO STUDIES WITH ANTIVIRAL AGENTS*". Annals of the New York Academy of Sciences 130, n.º 1 (16 de dezembro de 2006): 168–80. http://dx.doi.org/10.1111/j.1749-6632.1965.tb12550.x.

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9

DUFFY, S., P. C. REID e F. SHARP. "In-vivo studies of uterine electrosurgery". BJOG: An International Journal of Obstetrics and Gynaecology 99, n.º 7 (julho de 1992): 579–82. http://dx.doi.org/10.1111/j.1471-0528.1992.tb13824.x.

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10

Nikitin, Alexander, Yi Wang e Emmanuel Giannelis. "In vivo toxicity studies of nanoparticles". Toxicology Letters 180 (outubro de 2008): S222. http://dx.doi.org/10.1016/j.toxlet.2008.06.094.

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11

Iverson, F. "In vivo studies on butylated hydroxyanisole". Food and Chemical Toxicology 37, n.º 9-10 (setembro de 1999): 993–97. http://dx.doi.org/10.1016/s0278-6915(99)00091-5.

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12

Akhtar, Saghir, e Sudhir Agrawal. "In vivo studies with antisense oligonucleotides". Trends in Pharmacological Sciences 18, n.º 1 (janeiro de 1997): 12–18. http://dx.doi.org/10.1016/s0165-6147(96)01002-4.

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13

Wosu, L. O. "Feline panleucopenia — In vivo infectivity studies". Veterinary Microbiology 16, n.º 2 (fevereiro de 1988): 137–43. http://dx.doi.org/10.1016/0378-1135(88)90038-7.

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14

Heyman, P. W., C. S. Cho, J. C. McRea, D. B. Olsen e S. W. Kim. "Heparinized polyurethanes:In vitro andin vivo studies". Journal of Biomedical Materials Research 19, n.º 4 (abril de 1985): 419–36. http://dx.doi.org/10.1002/jbm.820190407.

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15

Rudnev, Sergey G. "11th International Symposium on In Vivo Body Composition Studies". Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), n.º 4 (17 de abril de 2019): 139–45. http://dx.doi.org/10.32521/2074-8132.2018.4.139-145.

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16

Mitrofanov, V. N., O. P. Zhivtsov, N. Yu Orlinskaya e D. V. Davydenko. "Experimental model of chronic focal osteomyelitis for in vivo studies". CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, n.º 1 (2021): 71–77. http://dx.doi.org/10.31088/cem2021.10.1.71-77.

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Introduction. The article describes an experimental model of chronic suppurative osteomyelitis in a rabbit. As new therapeutic and diagnostic algorithms for the supervision of patients with osteomyelitis appear, there is an growing need to compare the methods of surgical debridement and plasty of bone defects in an infectious process, in order to create experimental standardized pathological conditions as close to the clinical course of the disease in humans as possible. The aim of the study was to develop an experimental model of a standardized chronic purulent bone cavity, suitable for a comprehensive assessment of surgical debridement effectiveness and osteoplastic properties of bone substitute materials. Materials and methods. A standardized defect of the tibia in 24 rabbits was formed. The Staphylococcusaureus strain was used as an infectious agent. A dynamic assessment of the main indicators of blood counts in animals was carried out. The formation of chronic osteomyelitis was evaluated using radiography, com-puted tomography methods and histological studies. Results. It was shown that purulent bone wound developed in experimental animals with the technique cre-ated, and a defect with signs of a chronic purulent-inflammatory process was demonstrated. Conclusion. The proposed model of chronic osteomyelitis is reproducible. Operational flexibility and identi-cal in size and location bone defects allow to use this model in new osteoplastic material research. Keywords: chronic osteomyelitis, experiment, experimental animals

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17

Fusco, Roberta, Giacomo Perazzolo Gallo, Elio Di Bernardo, Valeria D’Alessio, Mattia Ronchetti, Matteo Cadossi e Ruggero Cadossi. "In Vivo and Ex Vivo Gene Electrotransfer in Ophthalmological Disorders". Biomedicines 10, n.º 8 (4 de agosto de 2022): 1889. http://dx.doi.org/10.3390/biomedicines10081889.

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The aim of this document is to present an overview of gene electrotransfer in ophthalmological disorders. In order to ensure an adequate variety of the assessed studies, several electronic databases were considered and studies published between January 1998 and December 2021 were analysed. Three investigators carried out data extraction and analysis, focusing on both technical (i.e., electrical protocol, type of electrode, plasmid) and medical (i.e., type of study, threated disease) aspects and highlighting the main differences in terms of results obtained. Moreover, the IGEA experience in the project “Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration” (TargetAMD) was reported in the results section. No clinical trial was found on international literature and on clinicaltrial.gov. Twelve preclinical studies were found including in vivo and ex-vivo applications. The studied showed that electrotransfer could be very efficient for plasmid DNA transfection. Many attempts such as modification of the electric field, buffers and electrodes have been made and the optimization of electric field setting seems to be very important. Using this technique, gene replacement can be designed in cases of retinal inheritance or corneal disease and a wide range of human eye diseases could, in the future, benefitfrom these gene therapy technologies.

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18

Rivas, Lourdes, Samuel Dulay, Sandrine Miserere, Laura Pla, Sergio Berdún Marin, Johanna Parra, Elisenda Eixarch et al. "Micro-needle implantable electrochemical oxygen sensor: ex-vivo and in-vivo studies". Biosensors and Bioelectronics 153 (abril de 2020): 112028. http://dx.doi.org/10.1016/j.bios.2020.112028.

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19

Babayeva, Mariana, Susan Cox, Michael P. White e David R. Taft. "Renal excretion of apricitabine in rats: ex vivo and in vivo studies". European Journal of Drug Metabolism and Pharmacokinetics 36, n.º 3 (6 de abril de 2011): 141–50. http://dx.doi.org/10.1007/s13318-011-0038-9.

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20

Bauer, Thomas-A. "Vivo, ergo sum-sanus: communication studies facing Health as a construction of social knowledge". Comunicar 13, n.º 26 (1 de março de 2006): 43–50. http://dx.doi.org/10.3916/c26-2006-07.

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A constructive theoretical view of everyday topics (in this paper context, we mean health) allows us to spot on communication models and cultural features of important daily aspects. This paper holds health up as a model of knowledge inside cultural programme fields. By drawing on this theoretical and scientist communication context, the relationship between health and its development can be shown as a pattern of life, taking always into consideration social conditions. Aunque la mayoría de los científicos compartan hoy el supuesto de que las ideas de salud y enfermedad son construcciones sociales relativas a estados físicos, psíquicos o sociales, sin embargo, todavía se mantienen planteamientos teóricos que, equivocadamente, conciben la salud o la enfermedad en relación con la comunicación. Este artículo busca fijar ambos conceptos –salud y enfermedad– en el marco de los estudios culturales, con la ayuda de la teoría de la observación y con referencias a una teoría sistémica constructivista.

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21

Zhang, Yanling, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft e Majella E. Lane. "Dermal Delivery of Niacinamide—In Vivo Studies". Pharmaceutics 13, n.º 5 (14 de maio de 2021): 726. http://dx.doi.org/10.3390/pharmaceutics13050726.

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In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In the present work, dermal delivery of NIA was investigated in vivo in human subjects using confocal Raman spectroscopy (CRS) and tape stripping (TS). The vehicles investigated included propylene glycol (PG), Transcutol® P (TC), binary combinations of PG with oleic acid (OA) or linolenic acid (LA) and a ternary system comprising of TC, caprylic/capric triglyceride (CCT) and dimethyl isosorbide (DMI). For the CRS studies, higher area under curve (AUC) values for NIA were observed for the PG:LA binary system compared with PG, TC and TC:CCT:DMI (p < 0.05). A very good correlation was found between the in vitro cumulative permeation of NIA and the AUC values from Raman intensity depth profiles, with a Pearson correlation coefficient (R2) of 0.84. In addition, an excellent correlation (R2 = 0.97) was evident for the signal of the solvent PG and the active. CRS was also shown to discriminate between NIA in solution versus crystalline NIA. The findings confirm that CRS is emerging as a powerful approach for dermatopharmacokinetic studies of both actives and excipients in human.

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22

Bulte, Jeff W. M. "In Vivo MRI Cell Tracking: Clinical Studies". American Journal of Roentgenology 193, n.º 2 (agosto de 2009): 314–25. http://dx.doi.org/10.2214/ajr.09.3107.

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23

METZGER, K., H. ZEILER e K. GROHE. "Ciprofloxacin: studies in vitro and in vivo". Biochemical Society Transactions 14, n.º 2 (1 de abril de 1986): 507. http://dx.doi.org/10.1042/bst0140507a.

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24

Wang, Ge, Wenxiang Cong, Kumar Durairaj, Xin Qian, Haiou Shen, Patrick Sinn, Eric Hoffman, Geoffrey McLennan e Michael Henry. "In vivo mouse studies with bioluminescence tomography". Optics Express 14, n.º 17 (2006): 7801. http://dx.doi.org/10.1364/oe.14.007801.

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25

Nair, Jerald J., Jaume Bastida e Johannes van Staden. "In Vivo Cytotoxicity Studies of Amaryllidaceae Alkaloids". Natural Product Communications 11, n.º 1 (janeiro de 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100134.

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The plant family Amaryllidaceae is recognizable for its esthetic floral characteristics, its widespread usage in traditional medicine as well as its unique alkaloid principles. Few alkaloid-producing families rival the Amaryllidaceae in terms of the diversity of its structures as well as their wide applicability on the biological landscape. In particular, cytotoxic effects have come to be a dominant theme in the biological properties of Amaryllidaceae alkaloids. To this extent, a significant number of structures have been subjected to in vitro studies in numerous cell lines from which several targets have been identified as promising chemotherapeutics. By contrast, in vivo models of study involving these alkaloids have been carried out to a lesser extent and should prove crucial in the continued development of a clinical target such as pancratistatin. This survey examines the cytotoxic effects of Amaryllidaceae alkaloids in vivo and contrasts these against the corresponding in vitro effects.

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26

Fontaine, Arthur B., e Susan Dos Passos. "Vascular Stent Prototype: In Vivo Swine Studies". Journal of Vascular and Interventional Radiology 8, n.º 1 (janeiro de 1997): 107–11. http://dx.doi.org/10.1016/s1051-0443(97)70524-4.

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27

Broglio, Fabio, Silvia Grottoli, Emanuela Arvat e Ezio Ghigo. "Endocrine actions of cortistatin: In vivo studies". Molecular and Cellular Endocrinology 286, n.º 1-2 (maio de 2008): 123–27. http://dx.doi.org/10.1016/j.mce.2007.12.012.

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28

Luo, Xuechun, Yufeng Jiang e Riqing Zhang. "In vivo dynamic studies of brain metabolism". Tsinghua Science and Technology 10, n.º 4 (agosto de 2005): 496–98. http://dx.doi.org/10.1016/s1007-0214(05)70106-1.

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29

Comment, Arnaud. "Dissolution DNP for in vivo preclinical studies". Journal of Magnetic Resonance 264 (março de 2016): 39–48. http://dx.doi.org/10.1016/j.jmr.2015.12.027.

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30

Eckelman, William C. "Radiolabeled muscarinic radioligands for in vivo studies". Nuclear Medicine and Biology 28, n.º 5 (julho de 2001): 485–91. http://dx.doi.org/10.1016/s0969-8051(01)00217-7.

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31

Meehan, A. G., D. L. Kreulen, P. C. Johnson, B. Liu, G. D. S. Hirst e T. C. Cunnane. "Electrophysiological studies on mesenteric arterioles in vivo". Journal of the Autonomic Nervous System 33, n.º 2 (maio de 1991): 180–81. http://dx.doi.org/10.1016/0165-1838(91)90197-b.

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32

Abercrombie, E. D. "Stress and brain norepinephrine:in vivo dialysis studies". Biological Psychiatry 35, n.º 9 (maio de 1994): 710. http://dx.doi.org/10.1016/0006-3223(94)90999-7.

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33

Sarre, S., D. Deleu, K. Van Belle, G. Ebinger e Y. Michotte. "In-vivo microdialysis sampling in pharmacokinetic studies". TrAC Trends in Analytical Chemistry 12, n.º 2 (fevereiro de 1993): 67–73. http://dx.doi.org/10.1016/0165-9936(93)87053-z.

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34

Lewis, James F. "In Vivo Studies of Aerosolized Exogenous Surfactant". Aerosol Science and Technology 22, n.º 4 (janeiro de 1995): 354–63. http://dx.doi.org/10.1080/02786829408959753.

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35

Corongiu, Francesco P., Silvana Vargiolu, Anna Milia, Kevin H. Cheeseman e Trevor F. Slater. "Antioxidants and lipid peroxidation: “In vivo” studies". Biochemical Pharmacology 34, n.º 3 (fevereiro de 1985): 397–98. http://dx.doi.org/10.1016/0006-2952(85)90057-7.

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36

Oberdürster, Güunter. "Toxicology of ultrafine particles: in vivo studies". Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences 358, n.º 1775 (15 de outubro de 2000): 2719–40. http://dx.doi.org/10.1098/rsta.2000.0680.

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37

Cairns, P., V. J. Morris, R. L. Botham e S. G. Ring. "Physicochemical Studies on Resistant StarchIn VitroandIn Vivo". Journal of Cereal Science 23, n.º 3 (maio de 1996): 265–75. http://dx.doi.org/10.1006/jcrs.1996.0027.

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38

Lee, Michael K., Dike Qiu, Christian Lesuisse, Paul Hoffman, Wanda Sterling e Donald L. Price. "Synucleins: In vitro and in vivo studies". Neurobiology of Aging 21 (maio de 2000): 284. http://dx.doi.org/10.1016/s0197-4580(00)83225-x.

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39

Reddi, Elena. "Far-red absorbing photosensitizers: in vivo studies". Journal of Photochemistry and Photobiology B: Biology 9, n.º 3-4 (junho de 1991): 395–96. http://dx.doi.org/10.1016/1011-1344(91)80191-j.

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40

Cowan, Alan, e Debra E. Gmerek. "In-vivo studies on kappa opioid receptors". Trends in Pharmacological Sciences 7 (janeiro de 1986): 69–72. http://dx.doi.org/10.1016/0165-6147(86)90257-9.

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41

Stokols, Daniel, Richard Harvey, Jennifer Gress, Juliana Fuqua e Kimari Phillips. "In vivo studies of transdisciplinary scientific collaboration". American Journal of Preventive Medicine 28, n.º 2 (fevereiro de 2005): 202–13. http://dx.doi.org/10.1016/j.amepre.2004.10.016.

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42

Gäbel, Jakob, Caroline Shams Hakimi, Martin Westerberg, Vladimir Radulovic e Anders Jeppsson. "Retransfusion of cardiotomy suction blood impairs haemostasis: Ex vivo and in vivo studies". Scandinavian Cardiovascular Journal 47, n.º 6 (16 de setembro de 2013): 368–76. http://dx.doi.org/10.3109/14017431.2013.838640.

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43

Zhu, Hong, Irene E. Kochevar, Irmgard Behlau, Jie Zhao, Fenghua Wang, Yucheng Wang, Xiaodong Sun, Michael R. Hamblin e Tianhong Dai. "Antimicrobial Blue Light Therapy for Infectious Keratitis: Ex Vivo and In Vivo Studies". Investigative Opthalmology & Visual Science 58, n.º 1 (27 de janeiro de 2017): 586. http://dx.doi.org/10.1167/iovs.16-20272.

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44

Jannesar, Kosar, Samin Abbaszadeh, Hassan Malekinejad e Hamid Soraya. "Cardioprotective effects of memantine in myocardial ischemia: Ex vivo and in vivo studies". European Journal of Pharmacology 882 (setembro de 2020): 173277. http://dx.doi.org/10.1016/j.ejphar.2020.173277.

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45

JOHNSSON, C., R. FESTIN, G. TUFVESON e T. H. TÖTTERMAN. "Ex Vivo PKH26‐Labelling of Lymphocytes for Studies of Cell Migration In Vivo". Scandinavian Journal of Immunology 45, n.º 5 (maio de 1997): 511–14. http://dx.doi.org/10.1046/j.1365-3083.1997.d01-430.x.

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46

Legon’kova, O. A., A. V. Chupin, A. S. Ogannisian, A. V. Nikitina, V. V. Stafford, I. P. Savchenkova, A. B. Varava, S. V. Sapelkin e S. V. Pozyabin. "In Vivo Studies of a Liquid Embolic Compound". Bulletin of Experimental Biology and Medicine 170, n.º 3 (janeiro de 2021): 360–63. http://dx.doi.org/10.1007/s10517-021-05067-w.

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47

Prieto, Luis I., Sara I. Graves e Darren J. Baker. "Insights from In Vivo Studies of Cellular Senescence". Cells 9, n.º 4 (13 de abril de 2020): 954. http://dx.doi.org/10.3390/cells9040954.

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Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype. Much of our molecular understanding in senescent cell biology comes from studies using mammalian cell lines exposed to stress or extended culture periods. While less well understood mechanistically, senescence in vivo is becoming appreciated for its numerous biological implications, both in the context of beneficial processes, such as development, tumor suppression, and wound healing, and in detrimental conditions, where senescent cell accumulation has been shown to contribute to aging and age-related diseases. Importantly, clearance of senescent cells, through either genetic or pharmacological means, has been shown to not only extend the healthspan of prematurely and naturally aged mice but also attenuate pathology in mouse models of chronic disease. These observations have prompted an investigation of how and why senescent cells accumulate with aging and have renewed exploration into the characteristics of cellular senescence in vivo. Here, we highlight our molecular understanding of the dynamics that lead to a cellular arrest and how various effectors may explain the consequences of senescence in tissues. Lastly, we discuss how exploitation of strategies to eliminate senescent cells or their effects may have clinical utility.

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48

Eremina, N. V., L. G. Kolik, R. U. Ostrovskaya e A. D. Durnev. "Preclinical in vivo Neurotoxicity Studies of Drug Candidates". Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 10, n.º 3 (18 de setembro de 2020): 164–76. http://dx.doi.org/10.30895/1991-2919-2020-10-3-164-176.

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Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity. Current experimental approaches to neurotoxicity assessment are cumbersome, laborious and not adapted enough for preclinical studies in the early stages of drug development. The aim of the study was to review existing approaches to experimental assessment of neurotoxic potential of new drugs and to discuss the need for and feasibility of developing and using integrated rapid neurotoxicity tests for early assessment of a pharmacological project’s potential. The authors reviewed scientific literature and guidance documents and analysed current approaches to chemical compound neurotoxicity assessment in laboratory animals. The paper analyses the main issues of neurotoxicity assessment for new drugs and compares Irwin tests with the functional observation battery. It analyses issues related to assessment of drugs’ effects on the development and maturation of central nervous system functions at pre- and postnatal stages. It was determined that the current practice is not sufficient for assessment of potential adverse effects on cognitive functions. The authors assessed factors affecting cognitive functions of rodents during studies. The “Acute suppression of the exploratory and orientation response” and “Extrapolation escape task” tests were proposed for validation as potential rapid tests for detection of an array of organic and functional neurotoxic disorders at early stages of preclinical studies.

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49

M. Abrantes, A., E. Serra, C. Goncalves, B. Oliveiros, M. Laranjo, A. B. Sarmento-Ribeiro, A. Rocha-Gonsalves e M. F. Botelho. "Tumour Hypoxia and Technetium Tracers: In Vivo Studies". Current Radiopharmaceuticalse 5, n.º 2 (1 de abril de 2012): 99–105. http://dx.doi.org/10.2174/1874471011205020099.

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50

Law, A., G. W. Jack, M. Tellez e C. J. Edmonds. "In-vivo studies of a human-thyrotrophin preparation". Journal of Endocrinology 110, n.º 2 (agosto de 1986): 375–78. http://dx.doi.org/10.1677/joe.0.1100375.

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ABSTRACT The effects on thyroid function of a new preparation of human thyrotrophin (hTSH) were studied in four subjects whose endogenous production of TSH had been suppressed by administration of thyroxine (T4). The hTSH, prepared from human cadaveric pituitary glands and highly purified using a monoclonal antibody technique, was given as an intravenous bolus of 2 i.u. hTSH. Serum TSH levels rose rapidly to a maximum of about 150 mu./l and then declined exponentially with a half-life of 100 min. After injection, the hTSH distributed rapidly in a volume averaging about 13 litres which corresponded approximately to the expected extracellular fluid volume of the subjects. Serum free tri-iodothyronine and free T4 rose significantly, reaching a maximum between 4 and 8 h after injection of hTSH; serum thyroglobulin was not altered significantly. The rise of thyroid pertechnetate uptake, a measure of the thyroid iodide uptake, occurred later, being only slightly increased at 8 h after administration of hTSH and reaching a maximum at 24 h. J. Endocr. (1986) 110, 375–378

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