Artigos de revistas sobre o tema "Joey Florez"

Solor Island, East Flores considered as one gate of the presence of three major religions (Islam, Catholicism, Christianity) in East Nusa Tenggara. The existence of Lohayong fort built by Portuguese (1566) became the beginning discussionabout history of religion in that area. This study was formulated to answer the question: whether Islam first present on the Solor Island? What kinds of evidencesthat prove of existence Islam on this island? Using archaeological and literature studies, the study concluded that there is some evidence like the presence of ulama Joe Pattiduri in Menanga at 13th century, the Fort of Menanga and the alliance of the five royal beach (Solor Watanlema). This facts also shows that Islam has been present before the Portuguese presence in the island. Keywords: Sites, Menanga, Watanlema Pulau Solor, Flores Timur menjadi saksi penting masuknya tiga agama besar (Islam, Katholik, Kristen) di Nusa Tenggara Timur (NTT). Keberadaan Benteng Lohayong yang dibangun Portugis (1566) menjadi awal diskusi masuknya agama di NTT. Penelitian ini dirumuskan untuk menjawab pertanyaan: apakah Islam lebih dahulu hadir di Pulau Solor? bukti apa saja yang bisa kita saksikan tentang Islam di Pulau Solor ini? Pendekatan kajian menggunakan studi arkeologi dan pustaka. Penelitian ini menyimpulkan bahwa ada beberapa bukti seperti hadirnya ulama Joe Pattiduri di Menanga abad 13, keberadaan Benteng Menanga dan Aliansi 5 kerajaan pantai Solor Watanlema. Fakta ini juga menunjukkan bahwa bahwa Agama Islam telah hadir sebelum Portugis hadir di Pulau Solor. Kata-kata Kunci: Situs, Menanga, Watan Lema

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR004) of the Conference Proceedings. Citation Format: Stanislav Avdieiev, Leticia Tordesillas, Omar Chavez Chiang, Zhihua Chen, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert Gatenby, Elsa R. Flores, Joel S. Brown, Kenneth Y. Tsai. In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr A017.

This article describes the diversity of languages ​​formed by the development of society in various aspects of life which includes various social activities, such as trade, government, health, education, and religion. The variety of languages ​​has functions such as the variety of languages ​​used by fish sellers in Oka market, Lamawalang, Larantuka District, East Flores Regency which grows and develops especially among speakers of the fish seller community. This variety of languages ​​can be found when fish sellers offer their fish to buyers where there is language contact, between Indonesian and local languages. The functions of various languages ​​used by fish sellers in the Oka Lamawalang market, Larantuka District, East Flores Regency with the Oka Lamawalang dialect include (1) instrumental (directive) functions, such as seducing, convincing, and asking, (2) interactional or interaction functions, such as asking , forms of interaction in the form of rejection and forms of agreement interaction, (3) representational or representational (declarative) functions such as showing and expressing, (4) personal functions, such as joy and disappointment.

"It is the supreme and splendid triumph of looking shallow and being deep," writes G.K. Chesterton, of "all French literature and philosophy." He may or may not be right about the French, but precisely that, looking shallow and being deep, is the triumph of the two great masters of English prose at the end of the Middle Ages, Thomas Malory and John Bourchier, Lord Berners. Both shared, appropriately enough, a passion for French literature, and that was not all, for they both wrote in that spirit that Richard Hooker articulated, memorably, years later, "that posterity may know we have not loosely through silence permitted things to pass away as in a dream." A world was passing away before them. They longed to capture and recreate imaginatively what they cherished in it, and where they succeeded in that intention, there their work runs deepest. So, at least, I will argue about Huon de Bordeaux in this paper, Huon being the first of Berners' two great literary achievements. In making my argument I will look at Berners' language, at aspects of his narrative, and at the surprising things he affirms with his jaunty and hard-edged materials.

Fokus penelitian ini menggali nilai-nilai etis yang terkandung dalam upacara Racang Ngi’is dan mengelaborasikan dengan konsep nilai menurut Max Scheler. Racang Ngi’is adalah upacara pendewasaan diri perempuan Riung-Flores. Setiap gadis Riung yang dipandang dewasa secara adat dan siap membina hidup rumah tangga harus melewati upacara tersebut. Akan tetapi, saat ini upacara Racang Ngi’is kurang diminati baik oleh generasi muda maupun masyarakat Riung. Hal ini disebabkan oleh beberapa faktor diantaranya; pertama, tidak ditemukan sumber tertulis tentang tata cara pelaksanaan upacara Racang Ngi’is. Kedua biaya yang cukup malah dan ketiga kaum muda Riung lebih tertarik terhadap budaya asing. Akibatnya, banyak gadis yang hidup berumah tangga tanpa melaksanakan upacara Racang Ngi’is terlebih dahulu. Peneliti menggunakan metode kualitatif dengan pendekatan studi literatur terkait tulisan-tulisan yang membahas tema penelitian dan mewawancarai beberapa narasumber sebagai sumber primer penelitian. Peneliti juga mengkaji beberapa artikel yang membahas proses pendewasaan diri di beberapa daerah seperti Nagekeo, Sabu, dan Bali sebagai sumber sekunder. Peneliti menemukan bahwa upacara Racang Ngi’is memiliki empat nilai yang terkandung di dalamnya yakni nilai kegembiraan, sosial, kepercayaan dan religius. Nilai-nilai tersebut memiliki tingkatan atau hierarki nilai dari yang terendah (kegembiraan) sampai tertinggi (religius). This research explores the ethical values contained in the Racang Ngi'is ceremony and elaborates on the concept of value according to Max Scheler. Racang Ngi'is is a coming-of-age ceremony for Riung-Flores women. Every Riung girl who is considered mature by custom and ready to build a household must go through the ceremony. However, currently the Racang Ngi'is ceremony is of less interest to both the younger generation and the Riung community. This is due to several factors including; firstly, no written sources were found about the procedures for performing the Racang Ngi'is ceremony. Secondly, the cost is quite prohibitive and thirdly the youth of Riung are more interested in foreign cultures. As a result, many girls married without performing the Racang Ngi'is ceremony first. The researcher used a qualitative method with a literature study approach related to writings that discuss the research theme and interviewed several sources as primary sources of research. The researcher also reviewed several articles that discussed the process of self-maturation in several regions such as Nagekeo, Sabu, and Bali as secondary sources. The researcher found that the Racang Ngi'is ceremony has four values contained in it, namely joy, social, belief and religious values. These values have a level or hierarchy of values from the lowest (joy) to the highest (religious).

Decimus Ausonius Magnus (ca 310-394) was a rhetorician, a teacher, a tutor of young Gratian and a highly-ranked, influential official, as well as one of the most famous poets of the late Roman Empire. In his poems, he frequently described the small world he belonged to, the daily routine of his own, of his relatives, professional colleagues and friends. As the poet reached his old age, he made it a subject of his poetry. Ausonius considers old age to be a blessing, a time which permits a wise, generous person to gather fruit of his good deeds and fulfilled duties, to watch children and grandchildren grow and achieve successes, to share one’s wisdom with younger persons. Ausonius shows his grandfather and his grand­mother, his aunts, but first of all his father, Ausonius senior, as the examples of happy old persons, loving and loved, respected and needed by the people who surrounded them. He notices that old persons can be joyful, healthy and beautiful. Writing about old age, he mentions illness only once, while expressing his joy of having recovered and being able to send greetings to the grandson who celebrates his birthday. In spite of his age, Ausonius still loves his wife Sabina, who died many years before, the same way as he loved her when he was a young husband. He is deeply attached to Bissula, the charming German girl cap­tured and given to him by the Emperor Valentinian I probably circa 368. Besides, he really enjoys spending time with his friends and with the Muses. In his epigrams, most of which don’t have personal, but rather literary character, the poet translates, quotes, paraphrases and imitates Greek and Latin epigrams which deal with the theme of old age. Although in Ausonius’ poems exists an obvious resemblance to their models, he grants himself much freedom in his remouldings. Not only he alters circumstantial details, expands or abbrevi­ates the original, bur also uses them as mere starting points of his reflexion. It becomes more important for him to ponder over quickly passing youth or over a lover’s feelings towards a woman who rejected him when she was young, but whom he still admires, than to play a literary game. Ausonius never parodies nor even portrays women trying to attire men in their old age, even though he may mock old men pretending to look younger than they are. Neither he complains about pains and sorrows of old age. In all that, he remains a true Roman and a true gentleman.

Este trabalho tem por objetivo analisar a relação entre memória e identidade na representação da figura feminina na obra Despida, da escritora maranhense Inês Pereira Maciel. A relação entre memória e identidade perpassa pela condição do sujeito de retraçar episódios dispersos do seu passado, como uma tentativa de compreensão de si mesmo. Para tanto, os episódios compartilhados com os membros da família, os emblemas (fotografias, objetos da sala de estar, dos quartos, as flores do jardim), bem como os lugares de vivências individuais e coletivas, em constante interação com o meio, as pessoas e com a vida, são aspectos salutares na ressignificação do vivido do eu que se pronuncia. A pesquisa é qualitativa, fundamentada na visão de Maurice Halbwachs (2006), Eclea Bosi (2003), Joel Candau (2012), no que se refere à memória; para a construção da identidade feminina usamos o pensamento de Zinani (2006), Rocha-Coutinho (1994), dentre outros. A obra Despida engloba poemas que tratam de perdas, tristezas, mas, sobretudo dos afetos do eu lírico feminino em torno dos elementos constitutivos da sua condição de existência, perpassando por uma subjetividade que evidencia a condição de ser mulher.

Abstract Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. Design Genomic profiling of GC patients including a Singapore cohort (>200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A-mutated GCs were analyzed to examine tumor microenvironmental changes arising from ARID1A loss. Genome-wide ARID1A binding and chromatin profiles (H3K27ac, H3K4me3, H3K4me1, ATAC-seq) of gastric cell lines were generated to identify gastric-specific epigenetic landscapes regulated by ARID1A. Distinct cancer hallmarks of ARID1A-mutated GCs were converged at the genomic, single-cell, and epigenomic level, and targeted by pharmacological inhibition. Results We observed prevalent ARID1A inactivation across GC molecular subtypes, with distinct mutational signatures and linked to a NFKB-driven pro-inflammatory tumour microenvironment. ARID1A-depletion caused loss of H3K27ac activation signals at ARID1A-occupied distal enhancers, but unexpectedly gain of H3K27ac at ARID1A-occupied promoters in genes such as NFKB1 and NFKB2. Promoter activation in ARID1A-mutated GCs was associated with enhanced gene expression, increased BRD4 binding, and reduced HDAC1 and CTCF occupancy. Combined targeting of promoter activation and tumour inflammation via bromodomain and NFKB inhibitors confirmed therapeutic synergy specific to ARID1A-genomic status. Conclusion Our results suggest a therapeutic strategy for ARID1A-mutated GCs targeting both tumour-intrinsic (BRD4-assocatiated promoter activation) and extrinsic (NFKB immunomodulation) cancer phenotypes. Citation Format: Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M. Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A. Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A. Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan, Singapore Gastric Cancer Consortium. Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P28.

Este número de la RPPP se inicia con un trabajo de Federico Lorenç Valcarce sobre el impacto de la pandemia sobre el funcionamiento de las fuerzas de seguridad durante la misma, en particular durante el periodo de aislamiento obligatorio y las limitaciones a la movilidad de las personas. Martín Carné presenta un estudio de caso sobre el Programa Nacional de Producción de Suelo orientado al financiamiento y cualificación de suelo por parte de estados provinciales y municipales con fines habitacionales; un programa que dio sus primeros pasos cuando la pandemia recién comenzaba. Partiendo de una revisión de la literatura y de la experiencia histórica argentina, Joseph Palumbo propone una conceptualización amplia de la política habitacional con el fin de renovar la agenta de investigación de las ciencias sociales en lo que toca a este tema. Martín Aguerre, Gustavo Acciaresi y Gerardo Andrés Denegri prestan atención a la evolución de la actividad forestoindustrial en la provincia de Jujuy y su relación con políticas de promoción e intervención del Estado en los distintos eslabones de las cadenas productivas. El artículo muestra la relevancia de la planificación estratégica en el desarrollo de la actividad y el retroceso que ella experimentó a medida que esa planificación se fue abandonando por el cambio de orientación de la gestión pública. El texto de Ana Clara Carro describe y analiza el proceso de federalización de la ciencia y la tecnología llevado adelante desde el Consejo Federal de Ciencia y Tecnología (COFECYT), orientado a la solución de problemas socio-productivos y a la adopción de decisiones por cada provincia a partir de la asignación de recursos, al mismo tiempo que señala la tensión que se suscita entre esa descentralización y la elección de criterios verdaderamente equitativos para la desconcentración de recursos. Daniel Comba presenta un estado actual del enfoque de diseño de políticas desarrollado por el análisis de políticas públicas estadounidense y los aportes provenientes de algunas perspectivas neoinstitucionalistas, señalando los puntos de acuerdo así como sus logros y limitaciones. Alberto Arellano Ríos, Santos Joel Flores Ascencio y Roberto Iván Piedra presentan un estudio de caso de un programa del gobierno federal de México de evaluación cualitativa y participativa de la población beneficiaria de los bienes y servicios generados por el programa analizado.

Abstract Introduction: Here, we demonstrate Protein Identification by Short-epitope Mapping (PrISM), which aims to provide comprehensive proteome analysis with broad dynamic range at single-molecule resolution by interrogating immobilized, intact proteins in parallel using multi-affinity probes. Improving the dynamic range and scale for protein analyses will enable a deeper understanding of low abundant protein in all stages of cancer progression. In addition, enabling the interrogation of single-molecules will provide a deeper understanding of protein diversity, such as the proteoforms resulting from non-canonical post-translational modifications inherent to cancer1. The combination of single-molecule sensitivity with comprehensive proteome coverage could also open the door for highly sensitive and specific diagnostics. Methods: PrISM uses non-traditional affinity reagents with high affinity and low specificity that bind to short epitopes in multiple proteins. Sample proteins were conjugated to DNA nanoparticles and deposited on a high-density patterned flow cell at optically resolvable locations. Multi-affinity probes were applied to sample proteins over multiple cycles to generate binding patterns for each single-molecule protein, which are translated to protein identifications and quantities using a custom machine learning approach. We acquired PrISM data on native biological and control samples using dozens of multi-affinity probes targeting trimer or tetramer sequences. Results: We report single-molecule deposition of over 1 billion DNA nanoparticle complexes on a flow cell. We demonstrate how the PrISM methodology identifies individual protein molecules through iterative probing with our multi-affinity probes. Further, we provide an analytical assessment of the sensitivity and specificity of PrISM and demonstrate the ability to accurately estimate the false identification rate of these proteins using a target-decoy based statistical approach. Conclusions: Combining single-molecule analysis, intact (non-digested) proteins, and iterative probing, PrISM provides a new tool for quantitative proteomics. We demonstrate linear and reproducible quantification of proteins using PrISM, potentially enabling detection of low abundant proteins and proteoforms associated with cancer. The ability to make comprehensive measurements of intact proteins at single-molecule resolution could accelerate basic cancer research through to the clinic. References: 1. Alfaro et al., Nature Methods, 2021. Citation Format: Torri Rinker, Jarrett D. Egertson, Steven Tan, Aisha Ellahi, Jamie Sherman, Maria Villancio-Wolter, Brittany Nortman, Julia Robinson, Ahana Dutta, Katherine Winters, Noah Steiner, Elvis Ikwa, Hunter B. Boyce, James H. Joly, Filip Bartnicki, Pierre F. Indermühle, Christina Inman, Shubhodeep Paul, Jacinto Villanueva, Jennifer McGinnis, Aimee A. Sanford, Sophia Watts, Jessica Nicastro, Sonal S. Tonapi, Jacob Devine, Cara Li, Kaitlyn Burke, Jonathan Leano, Nikola Kondov, Mirella Huber, Bilal Ali, Carlos Flores, Sheri K. Wilcox, Parag Mallick. Detection and quantification of proteins using protein identification by short-epitope mapping (PrISM). [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5305.

Abstract Background: The impact of chronic UV exposure on clonal dynamics and genomic diversity remains unclear. Our central hypothesis is that skin cancer is induced not by solely accumulation of somatic mutations, but rather a combination of mutations and disruption of the spatial and temporal constraints imposed by the skin’s 3-D architecture. Here we characterize clonal dynamics and transcriptional signatures during skin carcinogenesis using multicolor lineage tracing. Methods: We generated a K14Cre-ERT2 Confetti mice with inducible fluorophore (flr) expression. Mice were UV-irradiated for 3 months. Clones were 3-D digitized using confocal microscopy (z-stacks) and clone volumes estimated computationally. scRNAseq was used to compare UV-exposed (EXP) vs. non-exposed (NON) epidermis vs. skin tumors. Results: We generated 914 serial images of the EXP/NON skin over the course of 6 months following initiation of UV. We analyzed 16,135 clones from the EXP and 21,506 clones from the NON skin. We classified clone sizes into 3 classes represented by the small (<50,000 μm3), medium (50,000-500,000 μm3), and large “goliath” (> 500,000 μm3). The median size of clones does not differ between UV treatments and does not change with time. However, clones from EXP samples have significantly greater mean size than NON ones. Their mean sizes differed by some 1.5-fold, with an over 6-fold increase in variance, resulting in the sizes distribution to be highly skewed towards large clones with a long, narrow tail. Goliath clones are rarely present in the NON skin; however, they increase in number dramatically by months 3-4, plateauing between months 5-6. Using 3 ecological metrics (clone size, clone numbers, and coefficient of variation) we see phase shifts, which primarily distinguish months 1 & 2 from months 3 & 4. scRNAseq of EXP/NON epidermis and tumors revealed differential representation of 16 clusters, the majority of which could be mapped to previously defined keratinocyte populations. We observe dynamic changes to these clusters when progressing from normal skin to chronically exposed skin, and then to tumors. EXP clusters were associated with expression of cystatins (Scfa 3, BC100530), and alarmins/proliferative keratins (Krt16, Krt6a), which have been associated with skin injury. Clusters expressing cystatins and alarmins also increased in tumors. Flr-expressing keratinocytes harvested from large clones in EXP epidermis exhibited altered keratinocyte differentiation (downregulation of Krt77, Loricrin and Nfkbia, upregulation of cystatin), inflammation (downregulation of Nfkbia), and upregulation of metabolic regulators (carbonic anhydrase II and retinol transport (Rbp1)). Genes differentially expressed in exposed skin and retained in tumors may be required for carcinogenesis, while those expressed only in exposed skin likely required for adaptive responses to UV. Our findings have important implications for understanding cancer through an eco-evolutionary framework and designing novel approaches to cancer prevention. Citation Format: Stanislav Avdieiev, Leticia Tordesillas, Omar Chavez Chiang, Zhihua Chen, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert Gatenby, Elsa R. Flores, Joel S. Brown, Kenneth Y. Tsai. In vivo tracking of clonal dynamics during UV-induced skin carcinogenesis [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr PR004.

Chris Ballard, Paula Brown, R. Michael Bourke, Tracy Harwood (eds); The sweet potato in Oceania; A reappraisal (Peter Boomgaard) Caroline Hughes; The political economy of Cambodia’s transition, 1991-2001 (Han Ten Brummelhuis) Richard Robison, Vedi Hadiz; Reorganising power in Indonesia; The politics of oligarchy in an age of markets (Marleen Dieleman) Michael W. Charney; Southeast Asian warfare, 1300-1900 (Hans Hägerdal) Daniel Perret, Amara Srisuchat, Sombun Thanasuk (eds); Études sur l´histoire du sultanat de Patani (Mary Somers Heidhues) Joel Robbins; Becoming sinners; Christianity and moral torment in a Papua New Guinea society (Menno Hekker) Mujiburrahman; Feeling threatened; Muslim-Christian relations in Indonesia’s New Order (Gerry van Klinken) Marie-Odette Scalliet; De Collectie-Galestin in de Leidse Universiteitsbibliotheek (Dick van der Meij) James Neil Sneddon; Colloquial Jakartan Indonesian (Don van Minde) James Leach; Creative land; Place and procreation on the Rai coast of Papua New Guinea (Dianne van Oosterhout) Stanley J. Ulijaszek (ed.); Population, reproduction and fertility in Melanesia (Dianne van Oosterhout) Angela Hobart; Healing performances of Bali; Between darkness and light (Nathan Porath) Leo Suryadinata (ed.); Admiral Zheng He and Southeast Asia (Roderich Ptak) Ruth Barnes; Ostindonesien im 20. Jahrhundert; Auf den Spuren der Sammlung Ernst Vatter (Reimar Schefold) Marie-Antoinette Willemsen; Een missionarisleven in brieven; Willem van Bekkum, Indië 1936-1998 (Karel Steenbrink) Marie-Antoinette Willemsen; Een pionier op Flores; Jilis Verheijen (1908-1997), missionaris en onderzoeker (Karel Steenbrink) Akitoshi Shimizu, Jan van Bremen (eds); Wartime Japanese anthropology in Asia and the Pacific (Fridus Steijlen) Lilie Roosman; Phonetic experiments on the word and sentence prosody of Betawi Malay and Toba Batak (Uri Tadmor) Jamie D. Saul; The Naga of Burma; Their festivals, customs, and way of life (Nicholas Tapp) K.S. Nathan, Mohammad Hashim Kamali (eds); Islam in Southeast Asia; Political, social and strategic challenges for the 21st century (Bryan S. Turner) Andrew Pawley, Robert Attenborough, Jack Golson, Robin Hide (eds); Papuan pasts; Cultural, linguistic and biological histories of Papuan-speaking peoples (Lourens de Vries) Leo Howe, The changing world of Bali; Religion, society and tourism (Carol Warren) Sarah Weiss; Listening to an earlier Java; Aesthetics, gender, and the music of wayang in Central Java (Andrew N. Weintraub) REVIEW ESSAY Terry Crowley: Four grammars of Malakula languages Crowley, Terry (ed. by John Lynch); The Avava language of Central Malakula (Vanuatu) Crowley, Terry (ed. by John Lynch); Tape: a declining language of Malakula (Vanuatu Crowley, Terry (ed. by John Lynch); Naman: a vanishing language of Malakula (Vanuatu) Crowley, Terry (ed. by John Lynch); Nese: a diminishing speech variety of Northwest Malakula (Vanuatu) (Alexandre Francois) REVIEW ESSAY -- ‘The folly our descendants are least likely to forgive us’: the end of nature in Southeast Asia? Michael R. Dove, Percy E. Sajise, Amity A. Doolittle (eds); Conserving nature in culture; Case studies from Southeast Asia Jeyamalar Kathirithamby-Wells; Nature and nation; Forests and development in peninsular Malaysia Celia Lowe; Wild profusion; Biodiversity conservation in an Indonesian archipelago John F. McCarthy; The fourth circle; A political ecology of Sumatra’s rainforest frontier Budy P. Resosudarmo (ed.); The politics and economics of Indonesia’s natural resources Jeffrey R. Vincent, Rozali Mohamed Ali; Managing natural wealth; Environment and development in Malaysia (David Henley) In: Bijdragen tot de Taal-, Land- en Volkenkunde no. 163 (2007), no: 2/3, Leiden

Abstract Background: Trastuzumab deruxtecan (DS-8201a) is an antibody-drug conjugate (ADC), consisting of a humanized anti-HER2 (human epidermal growth factor receptor 2) monoclonal antibody linked to a topoisomerase I inhibitor payload using a cleavable tetrapeptide-based linker, approved for the treatment of HER2+ metastatic breast cancer patients refractory to anti-HER2 therapy including T-DM1. While some mechanisms for clinical T-DM1 resistance have been identified, less is known about innate or acquired resistance to DS-8201a. We established two XenoSTART Patient-Derived Xenograft (XPDX) models from tissue samples collected two years apart from a patient with ER+/HER2+ breast cancer before and after HER2 directed therapies. These models designated ST4565 and ST4565C were developed and characterized for receptor expression, genomic alterations, and in vivo drug sensitivities toward multiple chemotherapies and targeted agents, including T-DM1 and DS-8201a. Methods: Models ST4565 and ST4565C were established from breast samples collected from a Caucasian female with ER+/HER2+ metastatic breast cancer; ST4565 was collected at age 35 prior to therapy and ST4564C at age 37 following several treatment regimens including 5-FU/doxorubicin/cyclophosphamide, docetaxel/trastuzumab/pertuzumab, and T-DM1/anastrozole. Both were grown subcutaneously in female athymic nude mice supplemented with exogenous estradiol. The resulting models were passaged, and receptor expression confirmed immunohistochemically; genomic analysis, including WES and RNAseq, was performed to further characterize the models. For in vivo studies, both models were evaluated using several chemotherapy and targeted agents alone and in combination including: trastuzumab, pertuzumab, T-DM1, DS-8201a, neratinib, tucatinib, fulvestrant, alpelisib, sacituzumab, and irinotecan. In vivo study endpoints included tumor volume and time from treatment initiation with %T/C values and tumor regression reported at study completion; a T/C of ≤ 20% versus control was considered sensitive. Tumor regression (%T/C=< 0) versus Day 0 tumor volume was also reported. Results: ST4565 and ST4565C retained comparable receptor expression (ER=2+/HER2=3+) over tested passages with similar histology compared to archival clinical samples. DNA/RNA sequencing identified several conserved variants including loss of CDKN2A/B and MTAP and a CNV=14 for CCND1. In vivo, ST4565 and ST4565C were found resistant to T-DM1 at 3 mg/kg weekly with a T/C of 100% in both models. However, DS-8201a treatment at 3 mg/kg weekly resulted in partial tumor regressions in ST4565 (T/C=-51%) while ST4565C was found resistant (T/C=49%). Both models were found resistant to all tested chemotherapies and all other targeted therapies but reported similar sensitivity to fulvestrant (T/C=~40%). Conclusion: We established two XPDX models representing T-DM1-resistant, ER+/HER2+ breast cancer from breast samples collected two years apart from the same patient that were found differentially responsive to DS-8201a. These models can be utilized as a valuable tool in better understanding innate resistance to T-DM1 and acquired resistance to DS-8201a. Citation Format: George Plasko, Johnnie Flores, Alyssa Simonson, Peter Forofontov, Ashwin Varma, Amy Lang, Gladys Rodriguez, Kyriakos P. Papadopoulos, Drew Rasco, Amita Patnaik, Bruce Conway, Joe Johnston, Michael Wick. Establishment and characterization of two T-DM1-resistant, ER+/HER2+ breast XPDX models developed sequentially from the same patient with differential in vivo sensitivity to trastuzumab deruxtecan (DS-8201a) [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-13-03.

Esta edição do v. 22 n. 2 jul./dez 2023 da Revista Prisma Jurídico vem à público com onze artigos. Prisma Jurídico vem buscando ser um canal de produção científico-acadêmica, que almeja o seu aperfeiçoamento para atingir um estrato de excelência. Assim é que Prisma Jurídico recebe contribuições de autores nacionais e estrangeiros, a fim de garantir uma publicação de qualidade, com características de pluralidade e receptividade. Para tanto, Prisma Jurídico adota o método double blind peer review, pelo qual cada artigo é avaliado, ao menos por dois pareceristas especialistas na área com elevada titulação acadêmica, bem como são os artigos submetidos a um programa de verificação de similaridade de textos, a fim de se evitar fraudes e todas as modalidades de plágio. A publicação também se preocupa com a endogenia e garante a exogenia, com a efetiva possibilidade de trocas de informações entre as Instituições de Ensino Superior, requisito fundamental para a inserção nas bases indexadoras que emitem fatores de impacto mais elevados, com consequente classificação superior dos periódicos. O presente volume se inicia com o trabalho de Joel Ricardo Ribeiro de Chaves e Jorge Shiguemitsu Fujita, intitulado “Proteção de Dados Pessoais e Startups: uma visão do contexto brasileiro”, que trata da sociedade da informação, dos dados pessoais e da informação, na busca pelo desenvolvimento e a proteção de direitos e garantias humanas e fundamentais. O artigo promove revisões conceituais sobre startups e o direito à proteção de dados pessoais e busca examinar o direito à proteção de dados pessoais, diante da Lei Geral de Proteção de Dados Pessoais e da Resolução CD/ANPD nº 2/2022, do Conselho Diretor da Autoridade Nacional de Proteção de Dados. Na sequência, o artigo intitulado “Criação e Meta-autoria”, de Renan Melo de Sousa, Lorena Arruda e Marcia Cristina de Souza Alvim trata do uso das novas tecnologias nos trabalhos criativos humanos e suas consequências no âmbito jurídico, em especial a análise do instituto jurídico da propriedade intelectual e as novas possibilidades criativas. Depois, em “Cultura do litígio versus meios autocompositivos e a efetivação dos direitos da personalidade na pós-modernidade”, Daniely Cristina da Silva Gregório e Rodrigo Valente Giublin Teixeira examinam a figura da judicialização das controvérsias sociais enraizadas na sociedade brasileira e suas implicações na qualidade do serviço judiciário estatal, em face da dificuldade de efetivação de direitos. Com isso, analisam a cultura do litígio e os meios autocompositivos de solução de conflitos, enfatizando que estes podem efetivar os direitos da personalidade, gerando benefícios decorrentes da sua utilização, com função social transformadora, tanto para as partes envolvidas, como para a sociedade pós-moderna. O quarto artigo, nominado “Análise crítica da medida socioeducativa de internação nos casos de atos infracionais graves”, de José Fernando Vidal de Souza e João Carlos Saud Abdala Filho, se dedica a verificar a insuficiência da medida socioeducativa de internação nos casos mais graves, como o ato infracional equiparado ao crime de homicídio doloso e aos crimes hediondos e equiparados, quando praticados com violência ou grave ameaça. O artigo enfatiza que a evolução tecnológica, da aceleração do desenvolvimento de crianças e adolescentes, bem como do aumento da gravidade de atos infracionais exige uma necessária reforma do Estatuto da Criança e do Adolescente para adequá-lo à realidade atual no tocante às medidas socioeducativas. Ato contínuo, o artigo “Das ficções ao plano fático das medidas judiciais de exceção: a crise da segurança jurídica com os desvios na execução penal brasileira”, de Claudio José Langroiva Pereira e Bruno Girade Parise analisa a realidade carcerária brasileira, que segundo os autores, está permeada e sustentada por medidas judiciais de exceção. Em seguida, André Viana Custódio e Rafaela Preto de Lima, apresentam o artigo “Exploração sexual comercial de crianças e adolescentes: uma análise dos indicadores no estado do Rio Grande do Sul”, que trata da exploração sexual comercial de crianças e adolescentes no Estado do Rio Grande do Sul, examinada no período de 2010 a 2020. Em “A convenção internacional sobre os direitos das pessoas com deficiência ao tema 1.097 do STF: o direito à redução de carga horária ao servidor público com filho ou dependente com deficiência”, André Martini, Luiz Fernando Kazmierczak e Lucas Emanuel Ricci Dantas se dedicam a estudar a viabilidade jurídica para a concessão do benefício de redução de carga horária para o servidor público com filho ou dependente com deficiência, em face da Convenção Internacional sobre os Direitos das Pessoas com Deficiência e da interpretação dos Tribunais Estaduais e da recente decisão vinculante do STF, proferida no Tema 1.097. No oitavo artigo, nominado “A plasticidade do Direito do Trabalho na regulamentação dos serviços prestados via plataformas digitais: um estudo sobre o modelo Uber”, Ézio José Raulino Amaral, Antônio Cláudio Portella Serra e Silva e Maria Laura Lopes Nunes Santos abordam o desenvolvimento de tecnologias disruptivas, novos modelos de negócios, a partir do surgimento do modelo de negócio da empresa Uber e das relações de trabalho firmadas entre os motoristas e o aplicativo, diante das normas de Direito do Trabalho vigentes no país que, no entender dos autores, deve ser interpretado com maior plasticidade. Outrossim, em “A crise do Estado de Bem-Estar, a ruptura neoliberal e a resistência do homo politicus: uma análise a partir da obra de Wendy Brown”, Gilmar Antonio Bedin, Luis Gustavo Gomes Flores e Laura Mallmann Marcht destacam a importância da formação do Estado de Bem-Estar Social, sua crise e o surgimento de ideias neoliberais. Com isso, se debruçam sobre a obra de Wendy Brown e sobre sua teoria crítica da racionalidade liberal e algumas consequências do processo de (re)mercadorização das diversas esferas da vida coletiva consolidada nas últimas décadas, dentre elas o enfraquecimento dos direitos humanos e da cultura da igualdade, bem como o aumento significativo do populismo e da violência. No décimo artigo, “A importância do pensamento complexo e da interdisciplinaridade na defesa do patrimônio ambiental: uma abordagem jusfilosófica”, Severino Alexandre Biasoli e Luís Fernando Biasoli discutem a importância do pensamento complexo, da multidisciplinariedade e da epistemologia dialética para a criação, a avaliação e o desenvolvimento de normas ou de instituições jurídicas ambientais, em busca da defesa jurídica do equilíbrio ecológico do meio ambiente. O último artigo do presente volume trata sobre “O fomento público e a energia solar fotovoltaica a partir da lei nº 14.300/2022”, no qual Nicolle Suemy Mitsuhashi e Luiz Alberto Blanchet estudam a mencionada lei enquanto marco legal da micro e minigeração distribuída, com eventuais inovações e medidas de fomento público para a adoção dessa matriz energética. Assim, Prisma Jurídico agradece à toda equipe de editoração que auxiliou na realização do presente volume e deseja aos legentes, uma leitura prazerosa dos artigos apresentados.

One of the most important areas of mathematics education that must be developed from a young age is geometry. Various studies state that arithmetic, geometry, and measurement are three mathematical disciplines that must be prioritized in early childhood education. This research aims to determine the effect of the Somatic, Auditory, Visual, and Intellectual (SAVI) learning model on the geometric abilities of children aged 5-6 years. This research uses a pre-experimental experimental method with a one-group pretest-posttest design. The sample in this study was 18 children aged 5-6 years old Harapan Bunda Kindergarten Pancung Sol Pesisir Selatan. Data collection was obtained from observation and documentation, then the data was analyzed using paired sample tests. The results obtained in this research are that the SAVI model can improve the geometric abilities of children aged 5-6 years. This is known from the results of the paired sample t-test, which obtained a significance value of 0.000 < 0.05, which means Ho is rejected and Ha is accepted so that children's initial mathematical abilities, geometry, increase through the SAVI learning model. Children may become actively involved in their education with the help of the SAVI learning model, particularly when it comes to teaching them geometric forms. Because the teacher may utilize real items to aid in learning, children can recognize and retain the geometric forms around them as they grow older. Keywords: SAVI learning model, geometry ability, early childhood References: Alfiani, D. A. (2016). Penerapan Model Pembelajaran SAVI (Somatis, Auditori, Visual, Intelektual) Terhadap Hasil Belajar Aanak Usia Dini. Jurnal Pendidikan Anak, 2(1), 1-15. https://www.syekhnurjati.ac.id/jurnal/index.php/awlady/article/view/763 Amineh, R. J., & Asl, H. D. (2015). Review Of Constructivism And Social Constructivism. 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Geometry Learning in the Early Years : Developing Understanding of Shapes and Space with a Focus on Visualization. 73–95. http://doi.org/10.1007/978-981-10-7153-9_5 Gejard, G., & Melander, H. (2018). Mathematizing in preschool: Children’sparticipation in geometrical discourse. European Early ChildhoodEducation Research Journal, 26(4), 495-511. Gilmore, J. H., Knickmeyer, R. C., & Gao, W. (2018). Imaging Structural And Functional Brain Development In Early Childhood. Nature Review: Neuroscience. 19, 123-137. Gohel, K. (2020). A Study of effectiveness of auditory learning style instructional strategy on science achievement with reference to study habit. Purakala (UGC Care Journal), 31(4), 412-420. Hardy, J. K., & Hemmeter, M. L. (2019). Systematic Instruction of Early Math Skill For Preschoolers At Risk For Math Delays. Topics in Early Childhood Special EducationI, 38(4), 234-247. https://doi.org/10.1177/0271121418792300 Hariawan, R., Nurul, U., Muhammad, H. A. Y., & Imron, A. (2019). Contributions Management of Parenting and Education Program to Strengthen The Service Three Early Childhood Education Center. International Education Studies. 12 (2). http://doi.org/10.5539/ies.v12n2p100 Hosain,M., & Wiest,L.R. (2013). Collaborative Middle School Geometry Through Blogs And Otherweb 2.0 Technologies. Journal of Computers in Mathematics and Science Teaching, 32(3), 337–352. https://eric.ed.gov/?id=EJ1006190 Hwang, W. Y., Hoang, A., & Tu, Y. (2019). Exploring Authentic Contexts With Ubiquitous Geometry To Facilitate Elementary School Students’ Geometry Learning. The Asia-Pacific Education Researcher, 29, 269-283. https://doi.org/10.1007/s40299-019-00476-y Hwang, W. Y., Liu, Y. F., Purba, S. W. D., & Zhang, Y. Y. (2018). Investigation On The Effects Of Measuring Authentic Contexts On Geometry Learning. IEEE Transactions on Learning Technologies, 12, 291-302. Ivrendi, A., Erol, A., & Atan, A. (2018). Developing a test for geometry andspatial perceptions of 5-6 year old. Kastamonu Education Journal, 26(6). Kencanawati, S. A. M. M., Sariyasa, S., & Hartawan, I. G. N. Y. (2020). Pengaruh penerapan model pembelajaran SAVI (Somatic, Auditory, Visual, Intellectual) terhadap kemampuan berpikir kreatif matematis. Pythagoras: Jurnal Pendidikan Matematika, 15(1), 13–23. https://doi.org/10.21831/pg.v15i1.33006 Lee, J. E. (2017). Preschool Teachers’ Pedagogical Content Knowledge In Mathematics. International Journal of Early Childhood. 49, 229-243. Meier, D. (2000). The Accelerated Learning Handbook A Creative Guide To Designing And Delivering Faster, More Effective Training Programs. United Kingdom: McGraw-Hill. Murti, E. D., Nasir, N., & Negara, H. S. (2019). Analisis Kemampuan Pemecahan Masalah Matematis : Dampak Model Pembelajaran SAVI ditinjau dari Kemandirian Belajar Matematis. Desimal: Jurnal Matematika, 2(2), 119–129.https://doi.org/10.24042/djm.v2i2.4072. National Research Council. (2009). Mathematics Learning In Early Childhood: Paths Toward Excellence And Equity.Washington, DC : National Academies Press. Ozcakir, B., Konca, A. S., & Arikan, N. (2019). Children’s Geometric Understanding Through Digital Activities: The Case Of Basic Geometric Shapes. International Journal of Progressive Education, 15(3), 108-122. Parks, A. N. (2015). Exploring Mathematics Through Play In The Early Childhood Classroom. Teachers College Press. Partini, K. E., Wirya, I. N., & Ujianti, P. R. (2017). Pengaruh Metode Proyek Terhadap Kemampuan Mengenal Bentuk Geometri Pada Kelompok B Gugus I Singaraja Semester I. e-Journal Pendidikan Anak Usia Dini: Universitas Pendidikan Ganesha, 5(2), 210-219. https://ejournal.undiksha.ac.id/index.php/JJPAUD/article/view/12606/12967 Pauli, C., & Reusser, K. (2015). Co-constructivism in educational theory andpractice. International Encyclopedia of the Social and Behavioral Sciences.(Second Edition). 913-917 Raiyn, J. (2016). The Role of Visual Learning in Improving Students’ High-Order Thinking Skills. Journal of Education and Practice, 7(24), 115-121. http://iiste.org/Journals/index.php/JEP/article/view/32607/33498. Reeve, R. A. (2019). Mathematical Learning And Its Difficulties In Australia. International Handbook of Mathematical Learning Difficulties, 253–264. http://doi.org/10.1007/978-3-319-97148-3 _16 Rohman, N., Rustono., & Rifa’i, A. (2016). Cooperative Learning Model To Increasing Mathematical Concept For Early Childhood. Indonesian Journal of Early Childhood Education Studies, 5(1), 54-58. https://doi.org/10.15294/ijeces.v5i1.11277 Sahara, R., Mardiyana., & Saputro, D. R. S. (2018). Discovery Learning With SAVI Approach In Geometry Learning. Journal of Physics: Conference Series, 1013, 1-5. https://iopscience.iop.org/article/10.1088/1742-6596/1013/1/012125 Sarnoko., Ruminiarti., & Setyosari, P. (2016). Penerapan Pendekatan SAVI Berbantuan Video Pembelajaran Untuk Meningkatkan Aktivitas Dan Hasil Belajar IPS Siswa Kelas IV SDN I Sanan Girimarto Wonogiri. Jurnal Pendidikan, 1(7), 1235-1241. http://journal.um.ac.id/index.php/jptpp/article/view/6524 Selmi, A. M., Gallagher, R. J., & More-Flores, E. R. (2014). Early Childhood Curriculum For All Learners: Integrating Play And Literacy Activities. SAGE Publications. Septia, P., Pandra, V., & Mandasari, N. (2023). Penerapan Model Pembelajaran SAVI Dalam Pembelajaran Bangun Ruang Untuk Mengukur Hasil Belajar Matematika, Journal of Elemantary School (JOES), 6(2), 468-476. https://doi.org/10.31539/joes.v6i2.6661 Shoimin, A. (2014). 68 Model Pembelajaran Inovatif Dalam Kurikulum 2013. Yogyakarta: Ar-ruzz Media. Sulaksana, Y. T., Margunayasa, I. G., & Wibawa, I. M. C. (2018). Pengaruh ModelPembelajaran SAVI (Somatic Auditory Visualization Intellectualy) Berbantuan LKS terhadap Hasil Belajar IPA. 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A família Vochysiaceae abrange oito gêneros e mais de 200 espécies, são eles: Callisthene, Erisma,Qualea, Ruizterania, Salvertia, Vochysia. As espécies que representam a família podem serfacilmente encontradas no Cerrado Brasileiro, onde se destacam espécies de Qualea, conhecidaspopularmente como pau-terra e Vochysia, conhecidas como pau-de-tucano e cambará. Em geral autilidade econômica da família é o uso da madeira, pouco encontrada como parte de ornamentação(Souza & Lorenzi, 2005)Os gêneros de Vochysiaceae são plantas lenhosas com folhas simples, de disposição principalmenteoposta ou verticilada, com estípulas pequenas ou não. Flores grandes e vistosas, amarelas oubranco-amareladas, fortemente zigomorfas, cíclicas, diclamídeas, hermafroditas, com 1 ou 5pétalas. Sépala externa apresenta com uma grande espora (cálcar). Androceu formado por um únicoe grande estame. Ovário súpero tricarpelar, trilocular, com vários óvulos. Fruto seco, capsularloculicida, com sementes unilateralmente aladas. (Joly, 1975)Dentre as espécies de plantas que são geralmente encontradas em dunas e restingas no Brasil,algumas do gênero Vochysia (Vochysiaceae) são comuns.Este gênero engloba c. 100 espécies bemdistribuídas na diversas regiões do Brasil, especialmente nos ecossistemas de cerrado do BrasilCentral (Barroso, 1984) e 19 que ocorrem no estado da Bahia (Stafleu, 1948). Segundo França(2015) apenas Vochysia lucida e V. riedeliana ocorrem em áreas de restinga na BahiaAlgumas espécies de Vochysiaceae desenvolveram resistência a um dos elementos mais prejudiciaisàs plantas, o alumínio. Ele é um dos elementos de alto índice de toxicidade ao solo, econsequentemente às plantas. Encontrado em grande quantidade nos solos brasileiros, pois é um dosmateriais encontrados nas rochas intemperizadas. O Al é prejudicial ao crescimento edesenvolvimentos da maioria das plantas, no entanto, uma pequena porção de plantas desenvolveuresistência, e até mesmo uma dependência ao elemento, como algumas espécies de Vochysiaceae.(Miguel et al. 2010).Diante do fato das Vochysiaceae apresentarem uma associação com contaminação de alumínio nosolo, a partir do mapeamento da ocorrência das espécies será possível mapear a contaminação dealumínio. Permitindo melhor planejamento da expansão da fronteira agrícola. Para tanto énecessário identificar as espécies de Vochysiacae que apresentam tolerância ao alumínio. Depoisdisso, mapeia-se os nichos de ocorrência dessas espécies e teremos uma visão bastante próxima darealidade da contaminação de alumínio nos solos do estado da Bahia.

A família Vochysiaceae abrange oito gêneros e mais de 200 espécies, são eles: Callisthene, Erisma, Qualea, Ruizterania, Salvertia, Vochysia. As espécies que representam a família podem ser facilmente encontradas no Cerrado Brasileiro, onde se destacam espécies de Qualea, conhecidas popularmente como pau-terra e Vochysia, conhecidas como pau-de-tucano e cambará. Em geral a utilidade econômica da família é o uso da madeira, pouco encontrada como parte de ornamentação (Souza & Lorenzi, 2005).Os gêneros de Vochysiaceae são plantas lenhosas com folhas simples, de disposição principalmente oposta ou verticilada, com estípulas pequenas ou não. Flores grandes e vistosas, amarelas ou branco-amareladas, fortemente zigomorfas, cíclicas, diclamídeas, hermafroditas, com 1 ou 5 pétalas. Sépala externa apresenta com uma grande espora (cálcar). Androceu formado por um único e grande estame. Ovário súpero tricarpelar, trilocular, com vários óvulos. Fruto seco, capsular loculicida, com sementes unilateralmente aladas. (Joly, 1975).Alguns autores sugerem que determinadas espécies comuns do cerrado, pertencentes a família como Vochysiaceae, Rubiaceae e Melastomataceae, são acumuladoras de alumínio. As plantas relacionadas a este fenômeno se adaptaram a determinado tipo de solo. Algumas espécies ficam restritas a solos ácidos, enquanto outras são totalmente indiferentes ao tipo de solo. Em poucos casos, são bem sucedidas em solos calcários. (Jansen 2002).A acumulação de metais pesados é uma característica presente em, pelo menos 450 espécies diferentes, em algumas famílias a acumulação é considerada comum. Algumas espécies desenvolveram não só resistência, como também dependência ao elemento. (Miguel et al. 2010).O alumínio (Al) é um dos principais elementos disponíveis no interior da crosta terrestre e disponível em grande quantidade no solo. A presença de Al está diretamente ligada a solos com acidez alta. Um dos elementos de alto índice de toxicidade ao solo, e consequentemente às plantas. Encontrado em grande quantidade nos solos brasileiros, pois é um dos materiais encontrados nas rochas intemperizadas. O Al é prejudicial ao crescimento e desenvolvimentos da maioria das plantas. O elemento é altamente tóxico a diversas culturas. Apesar disto, algumas espécies criaram mecanismos de adaptação que lhes permitiram acumular Al sem o mesmo causar danos na produção.O objetivo deste projeto é identificar as concentrações de alumínio em solos onde espécies de Vochysiaceae crescem e deste modo mapear áreas que tenham predisposição para a acumulação de alumínio.

Editorial PhD. 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Pandey, MD Dhruvil J. Pandya, MD Nancy D. Papesh, BSN, RN, CFRN, EMT-B Helena Parfenova, PhD Min S. Park, MD Matthew S. Parsons, MD Aman B. Patel, MD Srinivas Peddi, MD Joanne Penko, MS, MPH Miguel A. Perez-Pinzon, PhD, FAHA Paola Pergami, MD, PhD Michael Phipps, MD Anna M. Planas, PhD Octavio Pontes-Neto, MD Shyam Prabhakaran, MD, MS Kameshwar Prasad, MD, DM, MMSc, FRCP, FAMS Charles Prestigiacomo, MD, FAANS, FACS G. Lee Pride, MD Janet Prvu Bettger, ScD, FAHA Volker Puetz, MD, PhD Svetlana Pundik, MD Terence Quinn, MD, MRCP, MBChb (hons), BSc (hons) Alejandro Rabinstein, MD Mubeen Rafay, MB.BS, FCPS, MSc Preeti Raghavan, MD Venkatakrishna Rajajee, MD Kumar Rajamani, MD Peter A. Rasmussen, MD Kumar Reddy, MD Michael J. Reding, MD Bruce R. Reed, PhD Mathew J. Reeves, BVSc, PhD, FAHA Martin Reis, MD Marc Ribo, MD, PhD David Rodriguez-Luna, MD, PhD Charles Romero, MD Jonathan Rosand, MD Gary A. Rosenberg, MD Michael Ross, MD, FACEP Natalia S. Rost, MD, MA Elliot J. Roth, MD, FAHA Christianne L. Roumie, MD, MPH Marilyn M. Rymer, MD, FAHA Ralph L. Sacco, MS, MD, FAAN, FAHA Edgar A. Samaniego, MD, MS Navdeep Sangha, BS, MD Nerses Sanossian, MD Lauren Sansing, MD, MSTR Gustavo Saposnik, MD, MSc, FAHA Eric Sauvageau, MD Jeffrey L. Saver, MD, FAHA, FAAN Sean I. Savitz, MD, FAHA Judith D. Schaechter, PhD Lee H. Schwamm, MD, FAHA Phillip Scott, MD, FAHA Magdy Selim, MD, PhD, FAHA Warren R. Selman, MD, FAHA Souvik Sen, MD, MS, MPH, FAHA Frank Sharp, MD, FAHA, FAAN George Shaw, MD, PhD Kevin N. Sheth, MD Vilaas Shetty, MD Joshua Shimony, MD, PhD Yukito Shinohara, MD, PhD Ashfaq Shuaib, MD, FAHA Lori A. Shutter, MD Cathy A. Sila, MD, FAAN Gisele S. Silva, MD Brian Silver, MD Daniel E. Singer, MD Robert Singer, MD Aneesh B. Singhal, MD Lesli Skolarus, MD Eric E. Smith, MD Sabrina E. Smith, MD, PhD Christopher Sobey, PhD, FAHA J David Spence, MD Christian Stapf, MD Joel Stein, MD Michael F. Stiefel, MD, PhD Sophia Sundararajan, MD, PhD David Tanne, MD Robert W. Tarr, MD Turgut Tatlisumak, MD, PhD, FAHA, FESO Charles H. Tegeler, MD Mohamed S. Teleb, MD Fernando Testai, MD, PhD Ajith Thomas, MD Stephen Thomas, MD, MPH Bradford B. Thompson, MD Amanda Thrift, PhD, PGDipBiostat David Tong, MD Michel Torbey, MD, MPH, FCCM, FAHA Emmanuel Touze, MD, PhD Amytis Towfighi, MD Richard J. Traystman, PhD, FAHA Margaret F. Tremwel, MD, PhD, FAHA Brian Trimble, MD Georgios Tsivgoulis, MD Tanya Turan, MD, FAHA Aquilla S. Turk, DO Michael Tymianski, MD, PhD, FRCSC Philippa Tyrrell, MB, MD, FRCP Shinichiro Uchiyama, MD, FAHA Luis Vaca, MD Renee Van Stavern, MD Susan J. Vannucci, PhD Dale Vaslow, MD, PHD Zena Vexler, PhD Barbara Vickrey, MD, MPH Ryan Viets, MD Anand Viswanathan, MD, PhD Salina Waddy, MD Kenneth R. Wagner, PhD Lawrence R. Wechsler, MD Ling Wei, MD Theodore Wein, MD, FRCPC, FAHA Babu Welch, MD David Werring, PhD Justin Whisenant, MD Christine Anne Wijman, MD, PhD Michael Wilder, MD Joshua Willey, MD, MS David Williams, MB, BAO, BCh, PhD, Dip.Med.Tox, FRCPE, FRCPI Linda Williams, MD Olajide Williams, MD, MS Dianna Willis, PhD John A. Wilson, MD, FACS Jeffrey James Wing, MPH Carolee J. Winstein, PhD, PT, FAPTA Max Wintermark, MD Charles Wira, MD Robert J. Wityk, MD, FAHA Thomas J. Wolfe, MD Lawrence Wong, MD Daniel Woo, MD, MS Clinton Wright, MD, MS Guohua Xi, MD Ying Xian, MD, PhD Dileep R. Yavagal, MD Midori A. Yenari, MD, FAHA William L. Young, MD Darin Zahuranec, MD Allyson Zazulia, MD, FAHA Adina Zeki Al Hazzouri, PhD John H. Zhang, MD, PhD Justin Zivin, MD, PhD, FAHA Richard Zorowitz, MD, FAHA Maria Cristina Zurru, MD

The UP Manila Health Policy Development Hub recognizes the invaluable contribution of the participants in theseries of roundtable discussions listed below: RTD: Beyond Hospital Beds: Equity,quality, and service1. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD,Faculty, College of Public Health, UP Manila2. Leonardo R. Estacio, Jr., MCD, MPH, PhD, Dean,College of Arts and Sciences, UP Manila3. Michael Antonio F. Mendoza, DDM, MM, Faculty,College of Dentistry, UP Manila4. Hilton Y. Lam, MHA, PhD, Chair, UP Manila HealthPolicy Development Hub; Director, Institute of HealthPolicy and Development Studies, University of thePhilippines Manila5. Irma L. Asuncion, MHA, CESO III, Director IV,Bureau of Local Health Systems Development,Department of Health6. Renely Pangilinan-Tungol, MD, CFP, MPM-HSD,Municipal Health Officer, San Fernando, Pampanga7. Salome F. Arinduque, MD, Galing-Pook AwardeeRepresentative, Municipal Health Officer, San Felipe,Zambales8. Carmelita C. Canila, MD, MPH, Faculty, College ofPublic Health, University of the Philippines Manila9. Lester M. Tan, MD, MPH, Division Chief, Bureau ofLocal Health System Development, Department ofHealth10. Anthony Rosendo G. Faraon, MD, Vice President,Zuellig Family Foundation (ZFF)11. Albert Francis E. Domingo, MD, Consultant, HealthSystem strengthening through Public Policy andRegulation, World Health Organization12. Jesus Randy O. Cañal, MD, FPSO-HNS, AssociateDirector, Medical and Regulatory Affairs, AsianHospital and Medical Center13. Christian Edward L. Nuevo, Health Policy and SystemsResearch Fellow, Health Policy Development andPlanning Bureau, Department of Health14. Paolo Victor N. Medina, MD, Assistant Professor 4,College of Medicine, University of the PhilippinesManila15. Jose Rafael A. Marfori, MD, Special Assistant to theDirector, Philippine General Hospital16. Maria Teresa U. Bagaman, Committee Chair, PhilippineSociety for Quality, Inc.17. Maria Theresa G. Vera, MSc, MHA, CESO III, DirectorIV, Health Facility Development Bureau, Departmentof Health18. Ana Melissa F. Hilvano-Cabungcal, MD, AssistantAssociate Dean for Planning & Development, Collegeof Medicine, University of the Philippines Manila19. Fevi Rose C. Paro, Faculty, Department of Communityand Environmental Resource Planning, University ofthe Philippines Los Baños20. Maria Rosa C. Abad, MD, Medical Specialist III,Standard Development Division, Health Facilities andServices Regulation21. Yolanda R. Robles, RPh, PhD, Faculty, College ofPharmacy, University of the Philippines Manila22. Jaya P. Ebuen, RN, Development Manager Officer,CHDMM, Department of Health23. Josephine E. Cariaso, MA, RN, Assistant Professor,College of Nursing, University of the Philippines Manila24. Diana Van Daele, Programme Manager, CooperationSection, European Union25. Maria Paz de Sagun, Project Management Specialist,USAID26. Christopher Muñoz, Member, Yellow Warriors SocietyPhilippinesRTD: Health services and financingroles: Population based- andindividual-based1. Hilton Y. Lam, MHA, PhD, Chair, University of thePhilippines Manila Health Policy Development Hub;Director, Institute of Health Policy and DevelopmentStudies, University of the Philippines Manila2. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD,Faculty, College of Public Health, University of thePhilippines Manila3. Leonardo R. Estacio, Jr., MCD, MPH, PhD, Dean,College of Arts and Sciences, University of thePhilippines Manila4. Michael Antonio F. Mendoza, DDM, MM, Faculty,College of Dentistry, University of the PhilippinesManila5. Mario C. Villaverde, Undersecretary, Health Policyand Development Systems and Development Team,Department of Health6. Jaime Z. Galvez Tan, MD, Former Secretary, Department of Health7. Marvin C. Galvez, MD, OIC Division Chief, BenefitsDevelopment and Research Department, PhilippineHealth Insurance Corporation8. Alvin B. Caballes, MD, MPE, MPP, Faculty, Collegeof Medicine, University of the Philippines Manila9. Carlos D. Da Silva, Executive Director, Association ofMunicipal Health Maintenance Organization of thePhilippines, Inc.10. Anthony Rosendo G. Faraon, MD, Vice President,Zuellig Family Foundation (ZFF) 11. Albert Francis E. Domingo, MD, Consultant, HealthSystem strengthening through Public Policy andRegulation, World Health Organization12. Salome F. Arinduque, MD, Galing-Pook AwardeeRepresentative, Municipal Health Officer, San Felipe,Zambales13. Michael Ralph M. Abrigo, PhD, Research Fellow,Philippine Institute for Developmental Studies14. Oscar D. Tinio, MD, Committee Chair, Legislation,Philippine Medical Association15. Rogelio V. Dazo, Jr., MD, FPCOM, Legislation,Philippine Medical Association16. Ligaya V. Catadman, MM, Officer-in-charge, HealthPolicy Development and Planning Bureau, Department of Health17. Maria Fatima Garcia-Lorenzo, President, PhilippineAlliance of Patients Organization18. Tomasito P. Javate, Jr, Supervising Economic DevelopmentSpecialist, Health Nutrition and Population Division,National Economic and Development Authority19. Josefina Isidro-Lapena, MD, National Board ofDirector, Philippine Academy of Family Physicians20. Maria Eliza Ruiz-Aguila, MPhty, PhD, Dean, Collegeof Allied Medical Professions, University of thePhilippines Manila21. Ana Melissa F. Hilvano-Cabungcal, MD, AssistantAssociate Dean for Planning & Development, College ofMedicine, University of the Philippines Manila22. Maria Paz P. Corrales, MD, MHA, MPA, Director III,Department of Health-National Capital Region23. Karin Estepa Garcia, MD, Executive Secretary, PhilippineAcademy of Family Physicians24. Adeline A. Mesina, MD, Medical Specialist III,Philippine Health Insurance Corporation25. Glorey Ann P. Alde, RN, MPH, Research Fellow,Department of HealthRTD: Moving towards provincelevel integration throughUniversal Health Care Act1. Hilton Y. Lam, MHA, PhD, Chair, University of thePhilippines Manila Health Policy Development Hub;Director, Institute of Health Policy and DevelopmentStudies, University of the Philippines Manila2. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD,Faculty, College of Public Health, University of thePhilippines Manila3. Leonardo R. Estacio, Jr., MCD, MPH, PhD, Dean,College of Arts and Sciences, University of thePhilippines Manila4. Michael Antonio F. Mendoza, DDM, MM, Faculty,College of Dentistry, University of the PhilippinesManila5. Mario C. Villaverde, Undersecretary of Health, HealthPolicy and Development Systems and DevelopmentTeam, Department of Health6. Ferdinand A. Pecson, Undersecretary and ExecutiveDirector, Public Private Partnership Center7. Rosanna M. Buccahan, MD, Provincial Health Officer,Bataan Provincial Office8. Lester M. Tan, MD, Division Chief, Bureau of LocalHealth System Development, Department of Health9. Ernesto O. Domingo, MD, FPCP, FPSF, FormerChancellor, University of the Philippines Manila10. Albert Francis E. Domingo, MD, Consultant, HealthSystem strengthening through Public Policy andRegulation, World Health Organization11. Leslie Ann L. Luces, MD, Provincial Health Officer,Aklan12. Rene C. Catan, MD, Provincial Health Officer, Cebu13. Anthony Rosendo G. Faraon, MD, Vice President,Zuellig Family Foundation14. Jose Rafael A. Marfori, MD, Special Assistant to theDirector, Philippine General Hospital15. Jesus Randy O. Cañal, MD, FPSO-HNS, Consultant,Asian Hospital and Medical Center16. Ramon Paterno, MD, Member, Universal Health CareStudy Group, University of the Philippines Manila17. Mayor Eunice U. Babalcon, Mayor, Paranas, Samar18. Zorayda E. Leopando, MD, Former President,Philippine Academy of Family Physicians19. Madeleine de Rosas-Valera, MD, MScIH, SeniorTechnical Consultant, World Bank20. Arlene C. Sebastian, MD, Municipal Health Officer,Sta. Monica, Siargao Island, Mindanao21. Rizza Majella L. Herrera, MD, Acting Senior Manager,Accreditation Department, Philippine Health InsuranceCorporation22. Alvin B. Caballes, MD, MPE, MPP, Faculty, Collegeof Medicine, University of the Philippines Manila23. Pres. Policarpio B. Joves, MD, MPH, MOH, FPAFP,President, Philippine Academy of Family Physicians24. Leilanie A. Nicodemus, MD, Board of Director,Philippine Academy of Family Physicians25. Maria Paz P. Corrales, MD, MHA, MPA, Director III,National Capital Region Office, Department of Health26. Dir. Irma L. Asuncion, MD, MHA, CESO III, DirectorIV, Bureau of Local Health Systems Development,Department of Health27. Bernard B. Argamosa, MD, Mental Health Representative, National Center for Mental Health28. Flerida Chan, Chief, Poverty Reduction Section, JapanInternational Cooperation Agency29. Raul R. Alamis, Chief Health Program Officer, ServiceDelivery Network, Department of Health30. Mary Anne Milliscent B. Castro, Supervising HealthProgram Officer, Department of Health 31. Marikris Florenz N. Garcia, Project Manager, PublicPrivate Partnership Center32. Mary Grace G. Darunday, Supervising Budget andManagement Specialist, Budget and Management Bureaufor the Human Development Sector, Department ofBudget and Management33. Belinda Cater, Senior Budget and Management Specialist,Department of Budget and Management34. Sheryl N. Macalipay, LGU Officer IV, Bureau of LocalGovernment and Development, Department of Interiorand Local Government35. Kristel Faye M. Roderos, OTRP, Representative,College of Allied Medical Professions, University ofthe Philippines Manila36. Jeffrey I. Manalo, Director III, Policy Formulation,Project Evaluation and Monitoring Service, PublicPrivate Partnership Center37. Atty. Phebean Belle A. Ramos-Lacuna, Division Chief,Policy Formulation Division, Public Private PartnershipCenter38. Ricardo Benjamin D. Osorio, Planning Officer, PolicyFormulation, Project Evaluation and MonitoringService, Public Private Partnership Center39. Gladys Rabacal, Program Officer, Japan InternationalCooperation Agency40. Michael Angelo Baluyot, Nurse, Bataan Provincial Office41. Jonna Jane Javier Austria, Nurse, Bataan Provincial Office42. Heidee Buenaventura, MD, Associate Director, ZuelligFamily Foundation43. Dominique L. Monido, Policy Associate, Zuellig FamilyFoundation44. Rosa Nene De Lima-Estellana, RN, MD, Medical OfficerIII, Department of Interior and Local Government45. Ma Lourdes Sangalang-Yap, MD, FPCR, Medical OfficerIV, Department of Interior and Local Government46. Ana Melissa F. Hilvano-Cabungcal, MD, AssistantAssociate Dean for Planning & Development, College ofMedicine, University of the Philippines Manila47. Colleen T. Francisco, Representative, Department ofBudget and Management48. Kristine Galamgam, Representative, Department ofHealth49. Fides S. Basco, Officer-in-charge, Chief Budget andManagement Specialist, Development of Budget andManagementRTD: Health financing: Co-paymentsand Personnel1. Hilton Y. Lam, MHA, PhD, Chair, University of thePhilippines Manila Health Policy Development Hub;Director, Institute of Health Policy and DevelopmentStudies, University of the Philippines Manila2. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD,Faculty, College of Public Health, University of thePhilippines Manila3. Leonardo R. Estacio, Jr., MCD, MPH, PhD, Dean,College of Arts and Sciences, University of thePhilippines Manila4. Michael Antonio F. Mendoza, DDM, MM, Faculty,College of Dentistry, University of the Philippines Manila5. Ernesto O. Domingo, MD, Professor Emeritus,University of the Philippines Manila6. Irma L. Asuncion, MHA, CESO III, Director IV,Bureau of Local Health Systems Development,Department of Health7. Lester M. Tan, MD, MPH, Division Chief, Bureau ofLocal Health System Development, Department ofHealth8. Marvin C. Galvez, MD, OIC Division Chief, BenefitsDevelopment and Research Department, PhilippineHealth Insurance Corporation9. Adeline A. Mesina, MD, Medical Specialist III, BenefitsDepartment and Research Department, PhilippineHealth Insurance Corporation10. Carlos D. Da Silva, Executive Director, Association ofHealth Maintenance Organization of the Philippines,Inc.11. Ma. Margarita Lat-Luna, MD, Deputy Director, FiscalServices, Philippine General Hospital12. Waldemar V. Galindo, MD, Chief of Clinics, Ospital ngMaynila13. Albert Francis E. Domingo, MD, Consultant, HealthSystem strengthening through Public Policy andRegulation, World Health Organization14. Rogelio V. Dazo, Jr., MD, Member, Commission onLegislation, Philippine Medical Association15. Aileen R. Espina, MD, Board Member, PhilippineAcademy of Family Physicians16. Anthony R. Faraon, MD, Vice President, Zuellig FamilyFoundation17. Jesus Randy O. Cañal, Associate Director, Medical andRegulatory Affairs, Asian Hospital and Medical Center18. Jared Martin Clarianes, Technical Officer, Union of LocalAuthorities of the Philippines19. Leslie Ann L. Luces, MD, Provincial Health Officer,Aklan20. Rosa Nene De Lima-Estellana, MD, Medical OfficerIII, Department of the Interior and Local Government21. Ma. Lourdes Sangalang-Yap, MD, Medical Officer V,Department of the Interior and Local Government 22. Dominique L. Monido, Policy Associate, Zuellig FamilyFoundation23. Krisch Trine D. Ramos, MD, Medical Officer, PhilippineCharity Sweepstakes Office24. Larry R. Cedro, MD, Assistant General Manager, CharitySector, Philippine Charity Sweepstakes Office25. Margarita V. Hing, Officer in Charge, ManagementDivision, Financial Management Service Sector,Department of Health26. Dr. Carlo Irwin Panelo, Associate Professor, College ofMedicine, University of the Philippines Manila27. Dr. Angelita V. Larin, Faculty, College of Public Health,University of the Philippines Manila28. Dr. Abdel Jeffri A. Abdulla, Chair, RegionalizationProgram, University of the Philippines Manila29. Christopher S. Muñoz, Member, Philippine Alliance ofPatients Organization30. Gemma R. Macatangay, LGOO V, Department ofInterior and Local Government – Bureau of LocalGovernment Development31. Dr. Narisa Portia J. Sugay, Acting Vice President, QualityAssurance Group, Philippine Health InsuranceCorporation32. Maria Eliza R. Aguila, Dean, College of Allied MedicalProfessions, University of the Philippines Manila33. Angeli A. Comia, Manager, Zuellig Family Foundation34. Leo Alcantara, Union of Local Authorities of thePhilippines35. Dr. Zorayda E. Leopando, Former President, PhilippineAcademy of Family Physicians36. Dr. Emerito Jose Faraon, Faculty, College of PublicHealth, University of the Philippines Manila37. Dr. Carmelita C. Canila, Faculty, College of PublicHealth, University of the Philippines ManilaRTD: Moving towards third partyaccreditation for health facilities1. Hilton Y. Lam, MHA, PhD, Chair, University of thePhilippines Manila Health Policy Development Hub;Director, Institute of Health Policy and DevelopmentStudies, University of the Philippines Manila2. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD,Faculty, College of Public Health, University of thePhilippines Manila3. Leonardo R. Estacio, Jr., MCD, MPH, PhD, Dean,College of Arts and Sciences, University of thePhilippines Manila4. Michael Antonio F. Mendoza, DDM, MM, Faculty,College of Dentistry, University of the PhilippinesManila5. Rizza Majella L. Herrera, MD, Acting SeniorManager, Accreditation Department, Philippine HealthInsurance Corporation6. Bernadette C. Hogar-Manlapat, MD, FPBA, FPSA,FPSQua, MMPA, President and Board of Trustee,Philippine Society for Quality in Healthcare, Inc.7. Waldemar V. Galindo, MD, Chief of Clinics, Ospital ngMaynila8. Amor. F. Lahoz, Division Chief, Promotion andDocumentation Division, Department of Trade andIndustry – Philippine Accreditation Bureau9. Jenebert P. Opinion, Development Specialist, Department of Trade and Industry – Philippine AccreditationBureau10. Maria Linda G. Buhat, President, Association ofNursing Service Administrators of the Philippines, Inc.11. Bernardino A. Vicente, MD, FPPA, MHA, CESOIV, President, Philippine Tripartite Accreditation forHealth Facilities, Inc.12. Atty. Bu C. Castro, MD, Board Member, PhilippineHospital Association13. Cristina Lagao-Caalim, RN, MAN, MHA, ImmediatePast President and Board of Trustee, Philippine Societyfor Quality in Healthcare, Inc.14. Manuel E. Villegas Jr., MD, Vice Treasurer and Board ofTrustee, Philippine Society for Quality in Healthcare,Inc.15. Michelle A. Arban, Treasurer and Board of Trustee,Philippine Society for Quality in Healthcare, Inc.16. Joselito R. Chavez, MD, FPCP, FPCCP, FACCP,CESE, Deputy Executive Director, Medical Services,National Kidney and Transplant Institute17. Blesilda A. Gutierrez, CPA, MBA, Deputy ExecutiveDirector, Administrative Services, National Kidney andTransplant Institute18. Eulalia C. Magpusao, MD, Associate Director, Qualityand Patient Safety, St. Luke’s Medical Centre GlobalCity19. Clemencia D. Bondoc, MD, Auditor, Association ofMunicipal Health Officers of the Philippines20. Jesus Randy O. Cañal, MD, FPSO-HNS, AssociateDirector, Medical and Regulatory Affairs, Asian Hospitaland Medical Center21. Maria Fatima Garcia-Lorenzo, President, PhilippineAlliance of Patient Organizations22. Leilanie A. Nicodemus, MD, Board of Directors,Philippine Academy of Family Physicians23. Policarpio B. Joves Jr., MD, President, PhilippineAcademy of Family Physicians24. Kristel Faye Roderos, Faculty, College of Allied MedicalProfessions, University of the Philippines Manila25. Ana Melissa Hilvano-Cabungcal, MD, AssistantAssociate Dean, College of Medicine, University of thePhilippines Manila26. Christopher Malorre Calaquian, MD, Faculty, Collegeof Medicine, University of the Philippines Manila27. Emerito Jose C. Faraon, MD, Faculty, College ofPublic Health, University of the Philippines Manila 28. Carmelita Canila, Faculty, College of Public Health,University of the Philippines Manila29. Oscar D. Tinio, MD, Representative, Philippine MedicalAssociation30. Farrah Rocamora, Member, Philippine Society forQuality in Healthcare, IncRTD: RA 11036 (Mental Health Act):Addressing Mental Health Needs ofOverseas Filipino Workers1. Hilton Y. Lam, MHA, PhD, Chair, University of thePhilippines Manila Health Policy Development Hub;Director, Institute of Health Policy and DevelopmentStudies, University of the Philippines Manila2. Leonardo R. Estacio, Jr., MCD, MPH, PhD, UPManila Health Policy Development Hub; College ofArts and Sciences, UP Manila3. Ma. Esmeralda C. Silva, MPAf, MSPPM, PhD, UPManila Health Policy Development Hub; College ofPublic Health, UP Manila4. Michael Antonio F. Mendoza, DDM, UP ManilaHealth Policy Development Hub; College of Dentistry,UP Manila5. Frances Prescilla L. Cuevas, RN, MAN, Director,Essential Non-Communicable Diseases Division,Department of Health6. Maria Teresa D. De los Santos, Workers Education andMonitoring Division, Philippine Overseas EmploymentAdministration7. Andrelyn R. Gregorio, Policy Program and Development Office,Overseas Workers Welfare Administration8. Sally D. Bongalonta, MA, Institute of Family Life &Children Studies, Philippine Women’s University9. Consul Ferdinand P. Flores, Department of ForeignAffairs10. Jerome Alcantara, BLAS OPLE Policy Center andTraining Institute11. Andrea Luisa C. Anolin, Commission on FilipinoOverseas12. Bernard B. Argamosa, MD, DSBPP, National Centerfor Mental Health13. Agnes Joy L. Casino, MD, DSBPP, National Centerfor Mental Health14. Ryan Roberto E. Delos Reyes, Employment Promotionand Workers Welfare Division, Department of Laborand Employment15. Sheralee Bondad, Legal and International AffairsCluster, Department of Labor and Employment16. Rhodora A. Abano, Center for Migrant Advocacy17. Nina Evita Q. Guzman, Ugnayan at Tulong para saMaralitang Pamilya (UGAT) Foundation, Inc.18. Katrina S. Ching, Ugnayan at Tulong para sa MaralitangPamilya (UGAT) Foundation, Inc.RTD: (Bitter) Sweet Smile of Filipinos1. Dr. Hilton Y. Lam, Institute of Health Policy andDevelopment Studies, NIH2. Dr. Leonardo R. Estacio, Jr., College of Arts andSciences, UP Manila3. Dr. Ma. Esmeralda C. Silva, College of Public Health,UP Manila4. Dr. Michael Antonio F. Mendoza, College of Dentistry,UP Manila5. Dr. Ma. Susan T. Yanga-Mabunga, Department ofHealth Policy & Administration, UP Manila6. Dr. Danilo L. Magtanong, College of Dentistry, UPManila7. Dr. Alvin Munoz Laxamana, Philippine DentalAssociation8. Dr. Fina Lopez, Philippine Pediatric Dental Society, Inc9. Dr. Artemio Licos, Jr.,Department of Health NationalAssociation of Dentists10. Dr. Maria Jona D. Godoy, Professional RegulationCommission11. Ms. Anna Liza De Leon, Philippine Health InsuranceCorporation12. Ms. Nicole Sigmuend, GIZ Fit for School13. Ms. Lita Orbillo, Disease Prevention and Control Bureau14. Mr. Raymond Oxcena Akap sa Bata Philippines15. Dr. Jessica Rebueno-Santos, Department of CommunityDentistry, UP Manila16. Ms. Maria Olivine M. Contreras, Bureau of LocalGovernment Supervision, DILG17. Ms. Janel Christine Mendoza, Philippine DentalStudents Association18. Mr. Eric Raymund Yu, UP College of DentistryStudent Council19. Dr. Joy Memorando, Philippine Pediatric Society20. Dr. Sharon Alvarez, Philippine Association of DentalColleges