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Teses / dissertações sobre o tema "Killer"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 26 de julho de 2025

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1

Robb, Simon. "Reading the serial killer /." Title page, contents and introduction only, 1994. http://web4.library.adelaide.edu.au/theses/09AR/09arr631.pdf.

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2

Nassiry, Ladan 1962. "Kinetics of Natural Killer (NK) cells in mice having elevated Natural Killer cell activity." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65512.

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3

Underhill, Holly J. "Stereotyping a Killer: Perceptions of Guilt, Deserved Punishment and Character of Mass Murderers and Killers." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/253.

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Attitudes of guilt, deserved punishment, and character of terrorists and mass murderers are examined in a hypothetical written scenario of a murder involving several casualties. The researcher hypothesizes that terrorists will be given harsher punishments. It is also hypothesized that White suspects will receive the least harsh punishments compared to the other suspects. The researcher also hypothesized that terrorists would be found guiltier than mass murderers. Results found that there were no significant differences in the punishments given to terrorists and mass murderers or between the ra

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4

Bélanger, Simon. "The role of natural killer cell receptors in the control of natural killer cell functions." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107643.

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Natural killer (NK) cells possess the ability to destroy abnormal cells such as cancerous and virally-infected cells. A common feature of these cells is the downregulation of class I MHC molecules in an attempt to evade recognition by CD8+ T lymphocytes. "Missing-self" recognition allows NK cells to identify and destroy cells with decreased MHC-I expression. MHC-I receptors are expressed by NK cells, therefore allowing "missing-self" recognition. The major MHC-I receptors on human NK cells are KIR while mouse NK cells express Ly49 receptors. In addition to the recognition of MHC-I on target ce

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5

Schaffrath, Raffael. "The killer system of Kluyveromyces lactis : molecular genetic analysis of killer plasmid K2 gene function." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34472.

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K. lactis killer strains carry two cytoplasmic, linear dsDNA plasmids, termed k1 and k2. DNA sequence analysis has revealed the presence of 14 plasmid-encoded ORFs. All genes are transcribed independently and all are preceded by putative promoter elements, the UCS motifs. Plasmid genes are generally not expressed when cloned with their own promoters into yeast nuclear vectors; similarly, cytoplasmic expression of genes carrying nuclear promoters does not occur when they are placed on k1 or k2. To overcome this compartmental incompatibility I have constructed suitable UCS-marker gene fusions fo

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6

Yap, Nicholas Andrew. "The sensitivity of yeasts to killer yeast toxins : with focus on the killer yeast Pichia membranifaciens /." Title page, abstract and contents only, 2000. http://web4.library.adelaide.edu.au/theses/09APSP/09apspy25.pdf.

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7

Carrotte, Andrew Paul. "Killer yeasts as antifungal biocontrol agents." Thesis, Abertay University, 2001. https://rke.abertay.ac.uk/en/studentTheses/a257159f-9b5f-4698-87b5-8f32963c7a99.

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The ability of killer yeast to inhibit the growth of fungi, specifically wood decay fungi, has been investigated. An initial broad screen of 17 yeast versus 17 fungi demonstrated that killer yeast can and do exhibit antagonistic as well as growth stimulatory affects on fungi. Yeast from the <i>Saccharomyces</i> and <i>Pichia</i> genera exhibited the greatest and broadest spectrum o f antagonism towards fungi and two yeasts one from each genus were studied further, namely S<i>accharomyces cerevisiae</i> K28 and <i>Pichia anomola</i> NCYC 750. Both yeast showed evidence of affecting fungal growt

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8

Samarra, Filipa Isabel Pereira. "Functional design and use of acoustic signals produced by killer whales (Orcinus orca)." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2564.

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This study aimed to investigate possible functions of the sounds produced by herring-eating killer whales in the Northeast Atlantic. In this study, I investigated the whistle repertoire of killer whales, which had previously only been studied in British Columbia, where it appeared to be restricted to the audible range. However, I show that high frequency whistles (> 17 kHz) were detected in Northeast Atlantic populations but not in Northeast Pacific populations. These results indicated substantial intraspecific variation in whistle production in killer whales. Little variation was observed in

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9

Ferreira, Inês Maria. "Growth and reproduction in false killer whales (Pseudorca crassidens Owens, 1840)." Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-02122009-154715/.

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Thesis (M.Sc.(Zoology and Entomology))--University of Pretoria, 2008.<br>The thesis is structured as three separate papers to be submitted to journals for publication, with a single reference list at the end. Includes bibliographical references (leaves 130-147).

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10

Runge, Anke. "Vergleichende Untersuchung der Funktion fetaler Natürlicher Killer T-Zellen mit Natürlichen Killer T-Zellen aus peripherem Blut Erwachsener." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-80309.

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11

El, Hmouzi-Younes Jamila. "Les cellules Natural Killer des ruminants : première caractérisation des cellules Natural Killer ovines et de bovin nouveau-né." Thesis, Tours, 2009. http://www.theses.fr/2009TOUR3802/document.

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Les nouveau-nés, dont le système immunitaire adaptatif est encore en développement sont souvent plus sensibles aux infections que les adultes. L’immunité innée constitue la première ligne de défense de l’organisme contre les agents pathogènes et en particulier les cellules Natural Killer (NK), via leur fonction cytotoxique et leur production d’interféron-gamma (IFN-?). Dans le but de pouvoir étudier, à terme, l’implication des cellules NK des ovins nouveau-nés dans un contexte infectieux, nous avons mis en place une stratégie permettant d’isoler et de caractériser ces cellules pour la première

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12

Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.

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[Truncated abstract] Natural killer (NK) cell alloreactivity can be exploited in haploidentical haematopoietic stem cell transplantation (HSCT) to improve graft survival, reduce graft versus host disease and decrease leukaemic relapse. NK cells lyse cells that have reduced expression of class I HLA molecules. In an allogeneic setting, donor NK cells may be activated by the absence of donor (self) class I HLA molecules on recipient cells; the absence of self-epitopes being detected by inhibitory KIR receptors on donor NK cells. The way in which genetic polymorphism of the receptors and ligands

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13

Freud, Aharon G. "Studies of human natural killer cell development." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1148068172.

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14

El-Jawhari, Jehan Jomaa El-Said. "Tumour-mediated inhibition of natural killer cells." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590426.

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The critical role of immune cells, in particular NK cells and cytotoxic T lymphocytes in recognition and elimination of tumour cells has been clearly demonstrated. However, immune evasion is a central hallmark of cancer; it negatively influences the prognosis and efficiency of therapies. Thus, understanding of this process will help to improve cancer therapy. Genetic alterations such as activation of oncogenes and loss of tumour suppressor genes are highly implicated in carcinogenesis. This study shows that the presence of KRAS oncogene reduced the surface expression of MHC class I on colorect

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15

Yadi, Hakim Adam. "Maternal killer lymphocytes, paternal antigens and reproduction." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608739.

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16

黃傑煇 and Kit-fai Wong. "CD56-positive: natural killer cell lymphoma/leukaemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3198177X.

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17

El-Sherbiny, Yasser Mohamed. "Natural killer cells and plasma cell neoplasia." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438481.

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18

Chang, Justin H. Chang. "The Killer: Moral Choice in Virtual Environments." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532035898806428.

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19

Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.

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20

Suck, Garnet, Yeh Ching Linn, and Torsten Tonn. "Natural Killer Cells for Therapy of Leukemia." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A71644.

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Clinical application of natural killer (NK) cells against leukemia is an area of intense investigation. In human leukocyte antigen-mismatched allogeneic hematopoietic stem cell transplantations (HSCT), alloreactive NK cells exert powerful anti-leukemic activity in preventing relapse in the absence of graft-versus-host disease, particularly in acute myeloid leukemia patients. Adoptive transfer of donor NK cells post-HSCT or in non-transplant scenarios may be superior to the currently widely used unmanipulated donor lymphocyte infusion. This concept could be further improved through transfusion

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21

Harris, Alison Jane. "Natural killer cell subsets and multiple sclerosis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14408.

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This thesis addresses the hypothesis that multiple sclerosis (MS) patients have an imbalance in the frequencies of natural killer cell subsets, with fewer immunoregulatory and more proinflammatory NK cells compared to healthy controls. Ten NK cell subsets were defined according to expression of CD56, CD8, CD27 and CD57. Subset frequencies were compared by performing multiparameter flow cytometry on PBMCs from healthy controls and patients with clinically isolated syndrome (CIS) or relapsing-remitting MS. CD56dim CD8+ CD57+ CD27- NK cells had a higher frequency in untreated relapsing-remitting

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22

Stringaris, Katherine. "Natural killer cells and acute myeloid leukaemia." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18014.

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Despite successful induction chemotherapy, most patients with acute myeloid leukemia (AML) will relapse. Immune surveillance by T cells or natural killer (NK) cells may play a role in preventing relapse. This thesis examines the potential of NK cells to control AML. Study 1 explored in 248 patients with haematological malignancies from the US National Institutes of Health, the genetic diversity of NK killer immunoglobulin receptor (KIR) genes in patients and their stem cell donors and their impact on outcome after stem cell transplantation (SCT) for haematological malignancy. Individuals with

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23

Wong, Kit-fai. "CD56-positive natural killer cell lymphoma/leukaemia /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23736197.

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24

Jaeger, Baptiste. "Acquisition of natural killer cell effector capabilities." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4028.

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Les cellules Natural Killer (NK) sont des lymphocytes du système immunitaire inné capables de tuer des cellules cibles et de produire des cytokines telles que l'interféron-γ. Au cours de mon travail de thèse, j'ai utilisé des approches de génétique directe et inverse dans le but d'étudier les mécanismes impliqués dans la régulation des capacités effectrices des cellules NK. La tolérance des cellules NK au soi est en partie assurée par les récepteurs inhibiteurs de surface qui sont spécifiques des molécules du complexe majeur d'histocompatibilité de classe I (CMH-I) exprimées par les cellu

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25

Parato, Karl G. "Normalization of natural killer cell activity with effective antiretroviral therapy coincides with restoration of natural killer cell receptor expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58492.pdf.

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26

Parsons, Matthew. "Lessons learned: natural killer cell education as a determinant of the anti-viral functional potential of natural killer cells." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114492.

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A vaccine against the human immunodeficiency virus (HIV) is urgently needed. Recent estimates predict that 34 million people are currently infected with HIV. Attempts to induce potentially protective cytotoxic T-lymphocytes or broadly neutralizing antibodies by vaccination have either proven unsuccessful or failed to elicit the desired immune responses. However, the recent RV144 vaccine trial that provided partial protection against HIV infection appears to have induced antibodies that can utilize cells of the innate immune system, such as natural killer (NK) cells, to mediate antibody-depende

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27

Senff, Tina [Verfasser], and Jörg [Akademischer Betreuer] Timm. "The role of Natural Killer cells and Natural Killer T cells in HCV infection / Tina Senff ; Betreuer: Jörg Timm." Duisburg, 2018. http://d-nb.info/1153338009/34.

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28

Moran, Michael. "Moving in for the Kill: Natural Killer Cell Localization in Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460446618.

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29

TANGUY-ROUGEAU, CHRISTINE. "Plasmides killer de la levure kluyveromyces lactis : - etude du gene nucleaire kex1 implique dans la maturation de la toxine killer; - etude fonctionnelle de genes des plasmides killer par modification in vivo." Paris 6, 1991. http://www.theses.fr/1991PA066353.

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Le systeme killer de kluyveromyces lactis est associe a la presence de deux adns lineaires k1 et k2. La toxine killer ainsi que le determinant de l'immunite sont codes par k1. K2 lui, est necessaire au maintien de k1. Ces deux plasmides ont un systeme de replication et de transcription propres, dans le cytoplasme de la cellule hote. Au cours de la premiere partie de cette these, le gene chromosomique kex1 a ete clone par complementation in vivo d'une mutation kex1 qui bloque la production de la toxine killer. La sequence de ce gene a ete etablie. Son produit code pour une endoprotease, respons

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30

Siu, Lai-ping Lisa. "The molecular pathology of natural killer cell malignancies /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25205195.

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31

Marsh, Jennifer Anne. "Social behavior and ecology of "southern resident" killer whales (Orcinus orca) /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/9081.

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32

Zhu, Yanting. "Cytotoxic dynamics of natural killer cell at the single cell level." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/590.

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Natural Killer (NK) cell, a crucial player of the human innate immune defense system, detects and kills virus-infected cells and cancer cells. Although the relevant molecular machineries involved in NK cell activation and NK-target cell interactions are largely known, how their collected dynamics regulate fast yet highly selective target cell killing in the complex environment of tissues is poorly understood. In traditional bulk killing assays, heterogeneity and kinetic details of individual NK-target cell interactions are masked, seriously limiting analysis of the underlying dynamic mechanism

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33

Troke, Angela D. "Investigation of the expression of leukophysin, a novel granule-associated protein, in natural killer cells and lymphokine-activated killer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/MQ57334.pdf.

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34

Pfeifer, Caroline [Verfasser], and Marcus [Akademischer Betreuer] Altfeld. "Association between Natural Killer Cell Education and Cellular Glucose Metabolism in Human Natural Killer Cells / Caroline Pfeifer ; Betreuer: Marcus Altfeld." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1179362616/34.

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35

Plé, Coline. "Rôle des cellules Natural Killer dans l'asthme allergique." Phd thesis, Université du Droit et de la Santé - Lille II, 2010. http://tel.archives-ouvertes.fr/tel-00473006.

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Les maladies allergiques sont en constante augmentation tant en prévalence qu'en gravité. Les mécanismes physiopathologiques connus impliquent l'induction d'une réponse Th2 par les cellules dendritiques, conduisant à une production d'IgE et une inflammation. L'immunité innée a récemment été mise en avant dans le contrôle de l'immunité adaptative, spécifique de l'antigène. Cependant, le rôle des cellules Natural Killer (NK), cellules de l'immunité innée connues essentiellement pour leurs fonctions anti-tumorales et anti-microbiennes, est encore inconnu dans la pathologie allergique. Néanmoins,

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36

Kamel, Fatemah Omar. "Invariant natural killer T cells in multiple sclerosis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40281.

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Invariant natural killer T (iNKT) cells are a subpopulation of lymphocytes that express both a CD1d-restricted αβ T cell receptor (TCR) and NK cell markers. iNKT cell perturbations are implicated in a wide variety of autoimmune diseases including Multiple Sclerosis (MS). Our results confirmed a significant reduction in the percentage of iNKT cells in MS patients with respect to healthy donors. In order to understand the immunological significance of iNKT cell reduction in MS, we aimed to define iNKT subsets in a cohort of MS patients of different disease types, Clinically Isolated Syndrome pat

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37

Kamya, Nabukenya. "Natural killer cells in HIV infected slow progressors." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104518.

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Acquired immunodeficiency syndrome AIDS-related illnesses are a leading cause of infectious disease mortality worldwide. The development of a safe and effective prophylactic HIV vaccine is an imperative global public health priority fraught with significant obstacles because the answers to fundamental immunological questions remain unknown. One such gap in knowledge includes the identification of the elusive correlates of immune protection against HIV.Untreated HIV infection is characterized by severe dysregulation of the antiviral immune response that begins during the earliest stages of infe

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38

Carlin, Leo Marc. "Imaging the human natural killer cell immunological synapse." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407501.

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39

Foote, Andrew D. "The evolutionary ecology of northeast Atlantic killer whales." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158398.

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In this thesis I take a multi-disciplinary approach to identify and characterise ‘Evolutionary Significant Units’ (ESUs) and ‘Management Units’ (MUs) of killer whale in the eastern North Atlantic. Several markers and traits including mitochondrial DNA control region, 15N stable isotope values, tooth wear, tooth count, total body length and pigmentation pattern indicated sympatric lineages could be categorized in to two ecologically & morphologically disparate types, which should be considered as distinct ESUs. One type (type 2) appears to be a specialist and may predate cetaceans. The other t

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40

Norgate, Zoe. "Gene expression in rat uterine natural killer cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614884.

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41

Chisholm, S. E. "Natural killer cell recognition of virally infected cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597615.

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Natural killer (NK) cells are known to be important for the control of viral infections, particularly infection with large double stranded (ds)DNA viruses such as herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), but the pathways and interactions important for NK cell recognition of virally infected cells are not well understood. Thus, the aim of this thesis was to study the molecular mechanisms of NK cell recognition of target cells infected with either HSV-1 or VV. Experiments using a set of HSV-1 mutants, deficient in one or more of the immediate early (IE) genes, demonstrated th

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42

邵麗平 and Lai-ping Lisa Siu. "The molecular pathology of natural killer cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243605.

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43

Hüber, Christian Markus. "Investigating adaptive immunological features of natural killer cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708920.

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44

Wantoch, Michelle Hannah. "Activation of natural killer cells by oncolytic viruses." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/21629/.

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45

Stewart, Charles Andrew Marshall. "Transcriptional regulation of the natural killer cell repertoire." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619751.

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46

Tosta, Christiann Davis. "Biotipagem de leveduras industriais através do sistema Killer." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/11/11141/tde-19042005-172224/.

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O setor agropecuário responde atualmente por cerca de 9,2% do Produto interno bruto (PIB) brasileiro, sendo que a cana-de-açúcar ocupa cerca de 9% da área cultivada, fato que lhe confere especial relevância com relação ao desenvolvimento nacional. Os dois produtos mais importantes desta cultura são o açúcar e o álcool etílico produzido por fermentação com leveduras. Durante o processo de fermentação alcoólica, o fermento sofre inúmeras reciclagens e interferências externas advindas do caldo, do ambiente e de outras fontes, tornando-se vulnerável à contaminação por outros microrganismos e mesmo

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47

Sabry, M. "Human natural killer cell responses to tumour-priming." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1435867/.

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As one of the central components of host anti-tumour immunity, natural killer (NK) cells exert cellular cytotoxicity against tumour cells and secrete a milieu of immunoregulatory cytokines to inhibit tumour progression. NK cell-mediated cytotoxicity requires successful progression through discrete activation events that begin with NK cell adhesion to a target cell and culminate in the polarized release of cytotoxic granules into the immunological synapse. These activation events are tightly regulated by a complex array of signalling molecules, the engagement of which by ligands on target cells

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48

Vourc'h, Mickaël. "Immunosubversion du Lymphocyte Natural Killer par Pseudomonas aeruginosa." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT1042/document.

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Pseudomonas aeruginosa (PA) est un pathogène opportuniste responsable d’infections pulmonaires chez le patient immunodéprimé. Parmi ses facteurs de virulence, PA exprime le système de sécrétion de type III (SSTIII) et ses effecteurs (Exoenzymes S, T et Y). Les cellules Natural Killer (NK) jouent un rôle clef dans la défense antibactérienne et particulièrement anti-PA. Leur activation est dépendante du microenvironnement myéloïde. Les NKs présentent 2 fonctions principales : La sécrétion de cytokine et la libération de granules cytotoxiques capables de lyser les cellules anormales. Nous avons é

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49

Damico, Nicole. "Preparing and Cloning a Natural Killer Cell Hybridoma." Youngstown State University / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1004458025.

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50

Roetynck, Sophie Virginie. "Cellules natural Killer et infection par Plasmodium falciparum." Aix-Marseille 2, 2006. http://theses.univ-amu.fr.lama.univ-amu.fr/2006AIX22081.pdf.

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La réponse immune dirigée contre Plasmodium falciparum, agent causal du paludisme chez l’homme, est le résultat de plusieurs milliers d’années de co-évolution entre le parasite et son hôte. Les cellules natural killer (NK) sont des lymphocytes cytolytiques innés, capables de produire des cytokines en réponse à l’infection. A la fois chez l’homme et la souris, elles apparaissent être une source majeure d’IFN- au tout début de l’infection palustre. Notre étude visait à décortiquer les bases moléculaires et cellulaires, ainsi que les conséquences fonctionnelles de l’activation des cellules NK au

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