Bibliografias temáticas / LC-MS

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Literatura científica selecionada sobre o tema "LC-MS"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 19 de abril de 2025

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Artigos de revistas sobre o assunto "LC-MS"

Carrascal, Montse, Klaus Schneider, R. Elena Calaf, Stefan van Leeuwen, Daniel Canosa, Emilio Gelpı́ e Joaquin Abian. "Quantitative electrospray LC–MS and LC–MS/MS in biomedicine". Journal of Pharmaceutical and Biomedical Analysis 17, n.º 6-7 (setembro de 1998): 1129–38. http://dx.doi.org/10.1016/s0731-7085(98)00078-8.

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Martínez-Huelamo, Miriam, Esther Jiménez-Gámez, Maria Pilar Hermo, Dolores Barrón e José Barbosa. "Determination of penicillins in milk using LC-UV, LC-MS and LC-MS/MS". Journal of Separation Science 32, n.º 14 (julho de 2009): 2385–93. http://dx.doi.org/10.1002/jssc.200900212.

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Huang, Eric C., e Jack D. Henion. "LC/MS and LC/MS/MS determination of protein tryptic digests". Journal of the American Society for Mass Spectrometry 1, n.º 2 (abril de 1990): 158–65. http://dx.doi.org/10.1016/1044-0305(90)85052-n.

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Barceló, Damià. "LC–tandem MS". TrAC Trends in Analytical Chemistry 24, n.º 7 (julho de 2005): 564–65. http://dx.doi.org/10.1016/j.trac.2005.05.004.

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S.C., Gilson. "Systèmes LC/MS". Biofutur 2000, n.º 198 (março de 2000): 11A. http://dx.doi.org/10.1016/s0294-3506(00)88768-2.

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Pinkston, J. David. "Comprehensive LC-MS". TrAC Trends in Analytical Chemistry 12, n.º 5 (maio de 1993): 225–26. http://dx.doi.org/10.1016/0165-9936(93)80024-e.

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Baghel, Madhuri, Meenakshi Bharkatiya, Alka Singh e Sadhana J. Rajput. "Stress Testing of Pidotimod by LC and LC-MS/MS". Biomedical and Pharmacology Journal 17, n.º 1 (20 de março de 2024): 517–26. http://dx.doi.org/10.13005/bpj/2878.

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Pidotimod is a synthetic biological and immunological modulator with dipeptide structure. It has been used for a long time to treat and prevent recurring respiratory infections. .Pidotimod stress testing and degradation profiling were carried out under ICH-recommended stress degradation protocols. To resolve Pidotimod and its impurities, the degradation products generated by various stress conditions were combined and separated on RP-C-18 column. LC-MS-MS study revealed existence of nine degradation products, six of which were previously unknown. On the basis of m/z values, degradation pathways for degradation products generated after stress testing were postulated.

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Kerns, Edward H., Kevin J. Volk, Susan E. Hill e Mike S. Lee. "Profiling Taxanes in Taxus Extracts Using Lc/ms and Lc/ms/ms Techniques". Journal of Natural Products 57, n.º 10 (outubro de 1994): 1391–403. http://dx.doi.org/10.1021/np50112a008.

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Kerns, Edward H., Kevin J. Volk, Susan E. Hill e Mike S. Lee. "Profiling new taxanes using LC/MS and LC/MS/MS substructural analysis techniques". Rapid Communications in Mass Spectrometry 9, n.º 15 (1995): 1539–45. http://dx.doi.org/10.1002/rcm.1290091514.

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Kushnir, Mark M., Alan L. Rockwood e Jonas Bergquist. "LC–MS/MS in clinical laboratories". Bioanalysis 5, n.º 1 (janeiro de 2013): 5–6. http://dx.doi.org/10.4155/bio.12.306.

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Teses / dissertações sobre o assunto "LC-MS"

Knight, S. J. "Separation and identification of RA2000 photographic developing solution components using LC, LC-MS and LC-MS-MS techniques". Thesis, Swansea University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637812.

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The analysis of photographic developing solutions presents an interesting and challenging problem for the analytical chemist. The developing agents themselves contain a wide range of components of various different chemistries, both inorganic and organic components are present at a wide range of concentrations. The developing agents as well has having a complex chemistry of their own, on use, are further complicated by the formation of products which can further affect the developing solutions performance. This work uses a variety of chromatographic and mass spectrometric techniques to examine a range of compounds present in the black and white Kodak developer RA2000. Emphasis is given to the application of these techniques to solving the analytical problem. The first chapter gives a theoretical introduction to mass spectrometry and liquid chromatography, with a discussion on the general principles in interfacing the two techniques. Chapter two gives a theoretical introduction to photography as well as an in depth discussion of developing solutions, specifically the RA2000 black and white developing solution. Analysis of RA2000 by liquid chromatography and capillary electrophoresis is also described. Chapter three provides an in depth discussion of solid phase extraction techniques as an alternative sample preparation method to liquid / liquid solvent extraction. Analysis of RA2000 by solid phase extraction and liquid chromatography was carried out in an attempt to concentrate the components formed after use, as well as to try and separate out the heavily concentrated compounds. Chapter four describes the analysis of RA2000 by liquid chromatography-thermospray-mass spectrometry and liquid chromatography-particle beam-mass spectrometry. An in depth discussion of both techniques is given. A column switching arrangement was used to allow analysis of the lower concentration components.

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Müller, Claudia. "Entwicklung von Screeningverfahren für Arzneistoffe und Metaboliten mittels LC-MS und LC-MS-MS". [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972115633.

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Seiwert, Bettina. "Ferro-based derivatizing agents for LC/MS an LC/EC/MS". Enschede : University of Twente [Host], 2007. http://doc.utwente.nl/57888.

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Gong, H. "Studies of nucleobases, nucleosides and nucleotides by LC, CZE, LC-MS, CZE-MS and MS techniques". Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637073.

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This work employs RP-HPLC and CE separation techniques, soft ionisation MS techniques (ESI and APCI), and on-line LC/MS, CE/MS and MS/MS techniques to analyse both the standards and nucleic acid constituents in mice livers. Emphasis is given to the method developments and the application of these techniques to tackle and solve biological and chemical problem. Chapter one gives an introduction to mass spectrometry, liquid chromatography and its separation modes, and also introduces and discusses several LC/MS interfaces based on their advantages, restrictions and their applications. Chapter two introduces capillary electrophoresis, its separation modes and CE/MS interfacing techniques with discussion of both sheath-liquid based on sheathless based CE/ME interfaces. Chapter three describes the analysis of nucleobases, nucleosides and nucleotide standards and nucleic acid constituents of the mice livers by on-line LC-APCI/MS and tandem MS/MS techniques, LSQ ion-trap and TSQ 700 were used to carry out the work above. Chapter four investigates fully and characterizes nucleobases, nucleosides, nucleotides and their isomers in several solvent systems by electrospray mass spectrometry (ES/MS). Develops analytical methods with LC-ES/MS, LC/MS/MS techniques and applies these techniques to examine the standards and identify several nucleobases, nucleosides and nucleotides in mice livers. Chapter five describes separation methods for nucleobases, nucleosides and nucleotides and their isomers by capillary electrophoresis with both uncoated silica combination techniques were employed to analyse standards of nucleobases, nucleosides, nucleotides and their isomers; and to analyse nucleic acid constituents in mice livers. Chapter six gives the conclusions and further research work in future. The relative merits of the use of LC-APCI/MS, LC-ESI/MS and CZE/MS techniques for the studies of nucleic acid constituents are compared.

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Hellmuth, Christian. "LC-MS/MS applications in Targeted Clinical Metabolomics". Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168254.

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Leavens, W. J. "Chemical derivatisation for LC-MS". Thesis, Swansea University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637863.

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The investigation of the chemical derivatisation of low molecular weight compounds containing carboxylic acid, amine, alcohol, aldehyde or ketone functional groups by novel reagents designed to enhance their response by liquid chromatography-electrospray ionisation mass spectrometry (LC-ESI/MS) is described. A series of novel reagents containing functionalised ferrocene or tris(2,4,6-trimethoxyphenyl)phosphonium (TMPP) moieties were synthesised for pre-column derivatisation of the target analytes. The ferrocene reagents enabled facile electrospray ionisation, through formation of the molecular cation or the protonated molecular ion, whilst the TMPP reagents provided a molecular cation (or "pre-charged" species). Additionally, the ferrocene reagents provided an elemental tag to facilitate analysis of the derivative by inductively coupled plasma mass spectrometry (ICP/MS). Carboxylic acids were activated by chloromethylpyridinium iodide in the presence of an organic base or by a water-soluble carbodiimide and reacted with an amine to produce a stable amide linkage. Both carboxylic acid and amine-containing analogues of ferrocene and TMPP were synthesised for use with this coupling reaction. Derivatisation of aldehydes and ketones was achieved by reaction of hydrazino analogues of TMPP to form hydrazone derivatives. Additionally, derivatisation was also achieved through the use of activated esters of ferrocene and TMPP and their nucleophilic displacement reaction with amines.

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Castelazo, Anahi Santoyo. "Comprehensive folate profiling in plants using LC-MS/MS". Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508152.

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Geiger, Armin Guntram. "Network-based contextualisation of LC-MS/MS proteomics data". Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/96116.

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Thesis (MSc)--Stellenbosch University, 2014.
ENGLISH ABSTRACT: This thesis explores the use of networks as a means to visualise, interpret and mine MS-based proteomics data. A network-based approach was applied to a quantitative, cross-species LCMS/ MS dataset derived from two yeast species, namely Saccharomyces cere- visiae strain VIN13 and Saccharomyces paradoxus strain RO88. In order to identify and quantify proteins from the mass spectra, a workflow consisting of both custom-built and existing programs was assembled. Networks which place the identifed proteins in several biological contexts were then constructed. The contexts included sequence similarity to other proteins, ontological descriptions, proteins-protein interactions, metabolic pathways and cellular location. The contextual, network-based representations of the proteins proved effective for identifying trends and patterns in the data that may otherwise have been obscured. Moreover, by bringing the experimentally derived data together with multiple, extant biological resources, the networks represented the data in a manner that better represents the interconnected biological system from which the samples were derived. Both existing and new hypotheses based on proteins relating to the yeast cell wall and proteins of putative oenological potential were investigated. These proteins were investigated in light of their differential expression between the two yeast species. Examples of proteins that were investigated included cell wall proteins such as GGP1 and SCW4. Proteins with putative oenological potential included haze protection factor proteins such as HPF2. Furthermore, differences in capacity for maloethanolic fermentation between the two strains were also investigated in light of the protein data. The network-based representations also allowed new hypotheses to be formed around proteins that were identified in the dataset, but were of unknown function.
AFRIKAANSE OPSOMMING: Hierdie studie verken die gebruik van netwerke om proteonomiese data te visualiseer, te interpreteer en te ontgin. 'n Netwerkgebaseerde benadering is gevolg ter ontleding van 'n kwantitatiewe LC-MS/MS datastel wat afkomstig was van twee gis-spesies nl, Saccharomyces cerevisiae ras VIN1 en Saccharomyces paradoxus ras RO88. Die massaspektra is met bestaande en selfgeskrewe rekenaarprogramme verwerk om 'n werkvloei saam te stel ter identifisering en kwantifisering van die betrokke proteïene. Hierdie proteïene is dan aan bestaande biologiese databasisse gekoppel om die proteïene in biologiese konteks te plaas. Die gekontekstualiseerde is dan gebruik om biologiese netwerke van die data te bou. Die kontekste beskou onder meer lokalisering van selaktiwiteite, ontologiese beskrywings, ooreenkomste in aminosuur-volgordes en interaksies met bekende proteïene asook assosiasie en verbintenisse met metaboliese paaie. Hierdie kontekstuele, netwerk-gebaseerde voorstelling van die betrokke prote- ïene het effektief duidelike data-tendense en patrone opgelewer wat andersins nie opmerkbaar sou wees nie. Daarby het die kombinering van eksperimentele data en bestaande biologiese bronne 'n beter perspektief aan die data-analise verleen. Beide bestaande en nuwe hipoteses tov gis-selwandproteïene en prote ïene met moontlike wynkundige potensiaal is ondersoek in die lig van hul differensiële uitdrukking in die twee gis-spesies. Voorbeelde wat ondersoek is sluit in selwandproteïene soos GGP1 en SCW4 asook waasbeskermingsfaktorproteïen HPF2. Verskille tov kapasiteit mbt malo-etanoliese gisting is ook gevind. Die netwerk-gebaseerde voorstellings het ook aanleiding gegee tot die formulering van nuwe hipoteses mbt datastel-proteïene waarvan die funksies tans onbekend is.

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Harder, Ulrike. "Amino acid analysis in biofluids using LC-MS/MS". Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-166180.

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Klinische Studien zeigen, dass die Zusammensetzung von zirkulierenden, freien AS im Blut, ein Marker für monogene und multigenetische Krankheiten ist. Die Analyse von hohen Probandenzahlen in klinischen Studien wird oftmals durch aufwendige und lange Probenaufarbeitungsschritte begrenzt. Im Rahmen der Metabolomics Plattform, die im Dr. von Haunerschen Kinderspitals etabliert wurde, wurde eine Hochdurchsatzmethode entwickelt, die eine selektive, sensitive, präzise und robuste Quantifizierung von 22 AS aus kleinen Probenvolumina ermöglicht. Im Laufe der Zeit konnten noch weitere Aminosäuren zur Methodik hinzugefügt werden. Dabei können innerhalb von 36 Stunden 96 Proben analysiert werden. Mit Hilfe eines deuterierten, interenen Standards in methanolischer Lösung werden Proteine aus nur 10 μL Probenvolumen gefällt. Zur Quantifizierung der AS wird anschliessend der eingedampfte Überstand derivatisiert und in Kombination mit einem Ionen-Paar- Reagenzes chromatographiert. Der Methodenaufarbeitung liegt eine umfassende und ausführliche Validierung zugrunde, die einer Interday Precision von 3.1 -10.8 % für alle Analyten erzielt. Zusätzlich unterzieht sich unsere Methode jedes Jahr an einem Ringversuch, der eine exakte Bestimmung aller Analyten gewährleistet. Im Zusammenhang mit der Programmierung des Stoffwechsels durch die Ernährung im Säuglingsalter wurde die neu entwickelte AS-Methode zur Quantifizierung von 726 Serum Proben in einer randomizierten klinischen Studie eingesetzt. Dabei wurde der Bezug zwischen Proteinzufuhr (Formelnahrung mit hohem Eiweißanteil bzw. niedriegem Eiweißanteil) und AS-Profil bei 6 Monate alten Säuglingen analysiert. Eine signifikante Veränderung der Plasmakonzentrationen zeigte sich in der Gruppe der formelernährten Kindern mit hohem Proteinanteil für folgende AS: BCAA, Gly, Lys, Met, Phe, Pro, Thr, Trp und Tyr. Essentielle AS werden über die Nahrung aufgenommen und vermutlich über das L-Transportsystem in die Zirkulation freigesetzt. Im Vergleich dazu werden nicht essentielle AS im Darm katabolisiert und mit Hilfe der de novo Synthese in gleichbleibenden Konzentrationen reguliert, sodass kein signifikanter Unterschied in beiden Gruppen beobachtet wurde. Durch eine proteinreiche Nahrung können AS vermehrt an der Aktivierung von Wachstumshormonen (mTOR, IGF-1) teilhaben, was sich im vermehrten Zellwachstum und –proliferation manifestiert. Nichts desto trotz kann die vermehrte Wachstumshormonaktivierung Krankheiten wie Insulinresistenz, Diabetes oder auch Übergewicht hervorrufen. Aufgrund des erhöhten Krankheitsrisikos ist einerseits von einer proteinreichen Ernährung im frühen Säuglingsalter abzuraten, andererseits kann das Stillen bzw. eiweißänhnliche Brustmilchzusammensetzung gesundheitsunterstützend sein. Auch im Rahmen eines Supplementierungsprojektes bei Kühen, hat sich die neu entwickelte AS-Methode bewährt. Dazu wurden jeweils 10 Kühe kurz vor und nach der Geburt mit CLA (CLA-Gruppe) oder mit Linolsäure (Kontroll-Gruppe) supplementiert. Ziel der Studie war es, den Zusammenhang zwischen CLA Supplementierung und AS- Profil im Blut zu analysieren. Dazu wurden zu insgesamt 8 Zeitpunkten vor und nach der Geburt, Blutproben entnommen. Es kristallisierten sich 3 verschiedene Zeitverläufe heraus, wobei die meisten AS-Konzentrationen nach der Geburt abfallen und langsam wieder auf ihre Ausgangswerte ansteigen. AS wie Glu sinken vor der Geburt stark ab, was dafür sprechen könnte, dass der Fetus mit ausreichend Glu versorgt wird und nach der Geburt vermehrt in die Milch transportiert wird. Gly, HPro, MHis und Ser steigen bis zur Geburt an und fallen dann wieder ab wobei Mhis durch den Muskelproteinabbau keinen Konzentrationsanstieg in den ersten 12 Laktationswochen erfährt. Die Supplementierung mit CLA zeigte keinen signifikanten Unterschied beider Gruppen auf das AS-Profil und zeigte somit keine Auswirkungen auf die AS-Synthese.
Clinical studies show that the composition of circulating free AA in blood, are a marker for monogenetic and multigenetic diseases. The analysis of a large number of subjects in clinical trials is often limited by complicated and long sample preparation steps. As part of the metabolomics platform established at the Dr. von Hauner Children ́s Hospital, a high-throughput method was developed which allows a selective, sensitive, precise and robust quantification of 22 AA from very small sample volumes. Over time further AA were added to the methodology. All AA of 96 samples can be measured within 36 hours. Using an internal standard in methanolic solution proteins were precipitated from only 10 μL sample volume. For AA quantification, the evaporated supernatant is derivatized and analyzed with an ion-pair reagent. The methodology is based on a comprehensive and detailed validation with an interday precision of 3.1- 10.8% for all analytes. Every year we participate in a collaborative study which ensures an accurate determination of all analyses. In the context of early programming, the newly developed AA method was used for quantifying 726 serum samples in a randomized clinical trial. Here, the relation between different protein intake (formula with high or low protein content) and AA profiles at 6 month old infants was analyzed. A significant alteration in serum concentration was found in the HP group for following AA: BCAA, Gly, Lys, Met, Phe, Pro, Thr, Trp und Tyr. Essential AA were taken by nutrients and probably released from the L-transport system into circulation. In comparison, non essential AA are catabolized in the intestine and regulated by de novo synthesis in equal concentrations. Therefore, no significant difference of non essential AA was observed between HP and LP group. High protein diet leads to an activation of growth hormones (mTOR, IGF-1) by enhanced availability of AA which is manifested in increased cell growth and proliferation. Nevertheless, the increased hormone activation can causes diseases such as insulin resistance, diabetes or obesity. Because of the increased risk for diseases a high protein diet in early infancy is not recommended but breast feeding or low protein diet can have beneficial effects for health. Within a cow supplementation project, the newly developed AA method has proved effective. From two weeks before to nine weeks after expected calving one group (CLA group, n=10) was supplemented with CLA and one group (control group, n=10) was supplemented with linoleic acid. The aim of the study was to analyze the relation between CLA supplementation and AA profiles in blood samples. These were taken at a total of eight times before and after delivery. We observed three different time courses of AA. In most cases AA levels decreased after delivery and afterwards concentrations increased slowly to their initial values. Glu is decreased before delivery which may indicate that the fetus is supplied sufficient with Glu. After delivery Glu is increasingly transported in the milk. Gly, HPro, MHis and Ser increased after delivery and then moved back to basal values where MHis did not increase in the first 12 weeks due to muscle protein breakdown. CLA supplementation showed no significant difference between the two groups on the AA concentrations and thus showed no effect on AA synthesis.

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Couchman, Lewis. "LC-MS/MS analysis of buprenorphine and norbuprenorphine in urine". Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511397.

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Livros sobre o assunto "LC-MS"

McMaster, Marvin. LC/MS. New York: John Wiley & Sons, Ltd., 2005.

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McMaster, Marvin C. LC/MS. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471736589.

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McMaster, Marvin C. LC/MS. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471736589.

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Cutillas, Pedro R., e John F. Timms, eds. LC-MS/MS in Proteomics. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-780-8.

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Analytical, Kratos. MS25 LC/MS data compilation. Ramsey, N.J: Kratos Analytical, 1985.

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Langman, Loralie J., e Christine L. H. Snozek, eds. LC-MS in Drug Analysis. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-934-1.

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Xu, Q. Alan, e Timothy L. Madden, eds. LC-MS in Drug Bioanalysis. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3828-1.

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Langman, Loralie J., e Christine L. H. Snozek, eds. LC-MS in Drug Analysis. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8823-5.

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Li, Wenkui, Jie Zhang e Francis L. S. Tse, eds. Handbook of LC-MS Bioanalysis. Hoboken, NJ, USA: John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.

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Achille, Cappiello, ed. Advances in LC-MS instrumentation. Amsterdam: Elsevier, 2007.

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Capítulos de livros sobre o assunto "LC-MS"

Güssregen, B. "LC-MS". In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_1834-1.

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Güssregen, B. "LC-MS". In Springer Reference Medizin, 1439–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1834.

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Bruins, A. P. "LC-MS and LC-MS-MS for Biomedical Analyses". In Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular, 339–51. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9424-3_48.

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Eswar, Deepthi. "LC-MS and LC-MS/MS Analysis of Food Spices". In Analysis of Food Spices, 197–207. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003279792-14.

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Krause, Joern, e Ronald Schmidt. "Bioanalytical Assays LC-MS/MS". In Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, 853–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-25240-2_35.

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Mandel, F. "LC/MS for Everybody/for Everything? - LC/MS Tips". In The HPLC-MS Handbook for Practitioners, 139–67. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527809202.ch4.

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Huang, Lihua, e P. Clayton Gough. "Characterization of PEGylated Biopharmaceutical Products by LC/MS and LC/MS/MS". In Methods in Molecular Biology, 351–63. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-921-1_22.

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Want, Elizabeth J. "LC-MS Untargeted Analysis". In Methods in Molecular Biology, 99–116. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7643-0_7.

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Bajad, Sunil, e Vladimir Shulaev. "LC-MS-Based Metabolomics". In Methods in Molecular Biology, 213–28. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-985-7_13.

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Matthiesen, Rune. "LC-MS Spectra Processing". In Mass Spectrometry Data Analysis in Proteomics, 59–77. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9744-2_2.

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Trabalhos de conferências sobre o assunto "LC-MS"

Dittwald, Piotr, Jerzy Ostrowski, Jakub Karczmarski e Anna Gambin. "Inferring serum proteolytic activity from LC-MS/MS data". In 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS). IEEE, 2011. http://dx.doi.org/10.1109/iccabs.2011.5729948.

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Peace, Robert, Travis Stewart, James Green e Jeff Smith. "Analysis of redundant peaks in LC-MS/MS datasets". In 2010 IEEE International Workshop on Medical Measurements and Applications (MeMeA). IEEE, 2010. http://dx.doi.org/10.1109/memea.2010.5480205.

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Chen, Long, Konstantinos Petritis, Tony Tegeler, Brianne Petritis, William E. Haskins e Jianqiu Zhang. "Improved Quantification of Labeled LC-MS". In 2011 IEEE International Conference on Bioinformatics and Biomedicine. IEEE, 2011. http://dx.doi.org/10.1109/bibm.2011.75.

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Miguel, A. C., J. F. Keane, J. Whiteaker, Heidi Zhang e A. Paulovich. "Compression of LC/MS Proteomic Data". In Proceedings. 19th IEEE International Symposium on Computer-Based Medical Systems. IEEE, 2006. http://dx.doi.org/10.1109/cbms.2006.2.

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Zurek, G. "LC-MS/MS as versatile tool in therapeutic drug monitoring". In XIIIth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1649544.

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Zhou, Bin, Jun Feng Xiao e Habtom W. Ressom. "A Computational Pipeline for LC-MS/MS Based Metabolite Identification". In 2011 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2011. http://dx.doi.org/10.1109/bibm.2011.89.

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Nunes, Maria João, Catarina V. Esteves, Mário Diniz, João Paulo Noronha e Luis C. Branco. "Nutritional Protein Value of Flours via LC-MS/MS Analysis". In International Meeting Molecules 4 Life, 10. Basel Switzerland: MDPI, 2024. http://dx.doi.org/10.3390/msf2023023010.

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Tsai, Tsung-Heng, Mahlet G. Tadesse, Yue Wang e Habtom W. Ressom. "Bayesian Alignment Model for LC-MS Data". In 2011 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2011. http://dx.doi.org/10.1109/bibm.2011.81.

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Ranjbar, M. R. N., Yue Wang e H. W. Ressom. "Quality assessment of LC-MS metabolomic data". In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW). IEEE, 2011. http://dx.doi.org/10.1109/bibmw.2011.6112551.

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SangWook Lee, Ji-Young Ahn, Soyoun Kim e Thomas Laurell. "Biomarker capturing platform using LC-ESI/MS/MS coupled aptamer microarray". In 2010 IEEE 10th Conference on Nanotechnology (IEEE-NANO). IEEE, 2010. http://dx.doi.org/10.1109/nano.2010.5697851.

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Relatórios de organizações sobre o assunto "LC-MS"

อุดมกาญจนนันท์, พรพรรณ, e สุชาดา จูอนุวัฒนกุล. การตรวจวิเคราะห์สารมาลาไคต์กรีนและเมตะบอไลต์ลิวโคมาลาไคต์กรีนตกค้างในสัตว์น้ำเพาะเลี้ยงด้วยเทคนิค LC-MS/MS และเทคนิค HPLC-UV-VISIBLE : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2007. https://doi.org/10.58837/chula.res.2007.57.

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งานวิจัยนี้ได้พัฒนาวิธีวิเคราะห์MG และ LMG พร้อมกันในตัวอย่างสัตว์น้ำเพาะเลี้ยง ให้มีความถูกต้องแม่นยำสูง ด้วยการเตรียมตัวอย่างที่มีขึ้นตอนงายและรวดเร็วขึ้น ใช้เตาอบไมโครเวฟในการสกัดและคลีนอัพ และวิเคราะห์ MG และ LMG ด้วยเทคนิค LC-MS/MS มีสารคริสตัลไวโอเล็ต (Crystal violet, CV) เป็น internal standard ที่ ionpairs ดังนี้ : MG 329.3/208.2, 329.3/313.1, LMG331.3/165.4, 331.3/239.3 และ CV (internal standard) 372.2/356.3 วิธีวิเคราะห์อีกวิธีหนึ่งคือการตรวจวิเคราะห์มาลาไคต์กรีน ลิวโคมาลาไคต์กรีน คริสตัลไวโอเล็ต ลิวโคคริสตัลไวโอเล็ต ตกค้างในสัตว์น้ำเพาะเลี้ยง เช่น ปลา กุ้ง พร้อมกันด้วยเทคนิค HPLC-DAD(multiwavelength) คอลัมน์ชนิด Zorbax stable bond C18, 150x4.6 mm, 5 [mu]m พร้อม guard column ชนิดเดียวกัน mobile phase คือ ammonium acetate buffer (0.05 M, pH 4.5) และ acetonitrile และใช้ gradient elution ตรวจวัดสารทั้งสี่ชนิดพร้อมกันด้วยเครื่องตรวจวัดแบบ diode array detector (DAD) ที่หลายความยาวคลื่นได้แก่ 618 nm(0.00-7.00 min), 585 nm(7.01-12.00 min), 265 nm(12.01-20.00 min) วิเคราะห์ปริมาณโดยอาศัย external calibration curve ของ total MG (ปริมาณ MG+LMG) และของ total CV (ปริมาณ CV+LCV)

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อุดมกาญจนนันท์, พรพรรณ, e สุชาดา จูอนุวัฒนกุล. การตรวจวิเคราะห์สารมาลาไคต์กรีนและเมตะบอไลต์ลิวโคมาลาไคต์กรีนตกค้าง ในสัตว์น้ำเพาะเลี้ยง ด้วยเทคนิค LC-MS/MS และเทคนิค HPLC-UV-VISIBLE : รายงานการวิจัยฉบับสมบูรณ์. คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2008. https://doi.org/10.58837/chula.res.2008.37.

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งานวิจัยนี้ได้พัฒนาวิธีวิเคราะห์ MG และ LMG พร้อมกันในตัวอย่างสัตว์น้ำเพาะเลี้ยง ให้มีความถูกต้องแม่นยำสูง ด้วยการเตรียมตัวอย่างที่มีขั้นตอนง่ายและรวดเร็วขึ้น ใช้เตาอบไมโครเวฟ ในการสกัดและคลีนอัพ และวิเคราะห์ MG และ LMG ด้วยเทคนิค LC-MS/MS มีสารคริสตัลไวโอเล็ต (Crystal violet, CV) เป็น internal standard ที่ ion pairs ดังนี้ : MG 329.3/208.2, 329.3/313.1, LMG 331 .3/165.4, 331.3/239.3 และ CV (internal standard) 372.2/356.3 วิเคราะห์ปริมาณด้วยวิธี standard addition method ร่วมกับ internal standard calibration method วิธีวิเคราะห์อีกวิธีหนึ่งคือการวิเคราะห์มาลาไคต์กรีน ลิวโคมาลาไคด์กรีน คริสตัลไวโอเล็ต ลิวโคคริสตัลไวโอเล็ต ตกค้างในสัตว์น้ำเพาะเลี้ยง เช่น ปลา กุ้ง พร้อมกันด้วยเทคนิค HPLC-DAD (multiwavelength) คอลัมน์ชนิด Zorbax stable bond C18, 150 x 4.6 mm, 5 um พร้อม guard column ชนิดเดียวกัน mobile phase คือ ammonium acetate buffer (0.05 m, pH 4.5) และ acetonitrile และใช้ gradient elution ตรวจวัดสารทั้งสี่ชนิดพร้อมกันด้วยเครื่องตรวจวัดแบบ diode array detector (DAD) ที่หลายความยาวคลื่นได้แก่ 618 nm (0.00-7.00 min), 585 nm (7.01-12.00 min), 265 nm (12.01- 20.00 min) วิเคราะห์ปริมาณโดยอาศัย external calibration curve ของ total MG (ปริมาณ MG+LMG) และของ total CV (ปริมาณ CV+LCV)

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Nelson, Bryant C., Elijah J. Petersen, Pawel Jaruga e Miral Dizdaroglu. LC-MS/MS Measurement of Nanomaterial- Induced DNA Modifications in Isolated DNA. National Institute of Standards and Technology, novembro de 2015. http://dx.doi.org/10.6028/nist.sp.1200-20.

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Peters, R. J. B., e W. Gebbink. Determination of pentachlorophenol in feed materials and compound feed by LC-MS/MS. Wageningen: Wageningen Food Safety Research, 2019. http://dx.doi.org/10.18174/478523.

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Moores, Lee, Ashley Kimble, Garrett George, David Henderson, Bobbi Stromer, Rebecca Crouch, Lauren Soblosky, Jared Smith e Anthony Bednar. Optimization of LC-MS/MS parameters for analysis of per- and polyfluoroalkyl substances (PFAS). Engineer Research and Development Center (U.S.), setembro de 2020. http://dx.doi.org/10.21079/11681/38237.

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Kimble, Ashley, Derek Muensterman, Liliana Cahuas, Ivan Titaley, Jennifer Field, Anthony Bednar e Lee Moores. Extraction and analysis of per- and polyfluoroalkyl Substances (PFAS) from Meals Ready-to-Eat (MRE) films using GC-MS and LC-MS/MS. Engineer Research and Development Center (U.S.), maio de 2023. http://dx.doi.org/10.21079/11681/47114.

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This work was in response to the Defense Logistic Agency’s (DLA) Subsistence Network Broad Agency Announcement, BAA-0003-16 addressing 2019 NDAA Section 329 that states packaging materials used for Meals Ready-to-Eat (MRE) that contact food products must be free of per- and polyfluoroalkyl substances (PFAS). This was addressed by determining the presence or absence of PFAS on MREs by extraction followed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography tandem mass spectrometry (LC-MS/MS). Any samples positive for PFAS were quantitated using LC triple quadrupole (QqQ) MS at the US Army Engineering and Research Development Center (ERDC) and by high resolution quadrupole time-of-flight (qTOF) MS and GC-MS at Oregon State University (OSU).

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Sullivan, Patrick Allen. Reduction of Solvent Effect in Reverse Phase Gradient Elution LC-ICP-MS. Office of Scientific and Technical Information (OSTI), dezembro de 2005. http://dx.doi.org/10.2172/861634.

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ว่องธวัชชัย, เจนนุข, e พรชัย โรจน์สิทธิศักดิ์. ปริมาณฮอร์โมนเมสทาโนโลนตกค้างในปลานิลหลังจากการกินฮอร์โมนในระยะเวลาสั้น : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.84.

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ปลานิลเป็นสัตว์น้ำเศรษฐกิจที่มีการเลี้ยงแบบหนาแน่น ลักษณะการเลี้ยงเป็นปลาเนื้อเพศผู้ (Monosex male tilapia) โดยการเหนี่ยวนำลูกปลาให้เจริญเป็นเพศผู้ด้วยการให้ฮอร์โมนเพศผู้แก่ลูกปลาวัยอ่อน เนื่องจากปลานิลเพศผู้มีการเจริญเติบโตดีกว่าเพศเมียและการเลี้ยงปลานิลแบบเพศผู้เพศเดียวเหมาะสมต่อการจัดการเมสทาโนโลนเป็นฮอร์โมนเพศผู้สังเคราะห์ชนิดหนึ่งที่มีการใช้ผสมอาหารให้ลูกปลากินในช่วงอนุบาลเพื่อวัตถุประสงค์ในการเหนี่ยวนำลูกปลกให้เจริญเป็นเพศผู้การวิจัยนี้ ทำการศึกษาประสิทธิภาพของเมสทาโนโลนในการเหนี่ยวนำเพศหลังจากการให้ลูกปลานิลกินฮอร์โมนขนาด 80 มิลลิกรัมต่อกิโลกรัมอาหาร ติดต่อเป็นระยะเวลา 15 วัน ประเมินผลการเหนี่ยวนำเพศปลานิล จากลักษณะของเนื้อเยื่อระบบสืบพันธุ์ระดับมหภาคและระดับมิญชวิทยาทำการตรวจวิเคราะห์ปริมาณฮอร์โมนตกค้างในลูกปลานิลที่ 1,2,3,5,7, 14 และ 21 วันหลังจากการหยุดให้กินฮอร์โมนผสมอาหารด้วยเทคนิค Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) ผลการศึกษา พบว่าการให้ลูกปลานิลกินฮอร์โมนขนาด 80 มิลลิกรัมต่อกิโลกรัมอาหารติดต่อกัน 15 วัน สามารถเหนี่ยวนำเป็นลูกปลาเพศผู้ได้ 100% และเมื่อหยุดให้อาหารผสมฮอร์โมนเป็นเวลา 1 วัน 2 วัน 3 วัน พบปริมาณเมสทาโนโลนในตัวอย่างลูกปลา 0.856-3.198 นาโนกรัมต่อปลา 1 กรัม และเมื่อหยุดให้อาหารผสมฮอร์โมนเป็นเวลา 5 วัน ไม่พบปริมาณเมสทาโนโลนในตัวอย่าง หรือปริมาณต่ำกว่าระดับต่ำสุดที่วิธีวิเคราะห์สามารถตรวจสอบได้อย่างถูกต้อง (0.5 นาโนกรัมต่อเนื้อปลา 1 กรัม) การศึกษานี้แสดงว่าการให้ฮอร์โมนเมสทาโนโลนขนาด 80 มิลลิกรัมต่อกิโลกรัมอาหารเป็นระยะเวลา 15 วันแก่ลูกปลานิลวัยอ่อน สามารถเหนี่ยวนำให้ลูกปลานิลเจริญเป็นปลาเพศผู้และปลานิลขนาดบริโภคซึ่งเลี้ยงต่อจากระยะเวลาหยุดการให้ฮอร์โมนแล้ว 6-8 เดือน จึงไม่มีปริมาณฮอร์โมนตกค้างในระดับที่อาจเป็นอันตรายต่อผู้บริโภค

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Browner, R. F. Fundamental studies with a monodisperse aerosol-based liquid chromatography/mass spectrometry interface (MAGIC-LC/MS). Office of Scientific and Technical Information (OSTI), outubro de 1990. http://dx.doi.org/10.2172/6179424.

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Wang, Jin. Elemental speciation in biomolecules by LC-ICP-MS with magnetic sector and collision cell instruments. Office of Scientific and Technical Information (OSTI), novembro de 1999. http://dx.doi.org/10.2172/754790.

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