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Artigos de revistas sobre o tema "LC-MS (Liquid Chromatography-Mass Spectrometry)"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Archita, Tiwari, Dubey Vishwanath, Mishra Shilpi, et al. "General Instrumentation of LC-MS Technique and their Recent Applications." International Journal of Innovative Science and Research Technology 7, no. 5 (2022): 1469–73. https://doi.org/10.5281/zenodo.6760060.

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This review summarizes the advancement in liquid chromatography-mass spectrometry (LC-MS). Liquid Chromatography and Mass Spectrometer is a hyphenated technique of separation of compounds. over the past years, the combination 0f high-performance liquid chromatography and mass spectrometry (LC-MS) has been used which has a remarkable effect on drug research and development. LC-MS played a vital role in the assessment and interpretation of bioavailability and bioequivalence. This article reviews the principle of LCMS analysis using liquid chromatography and mass spectrometry. Mass spectrometry c

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Radović, Radmila, Bojana Radić, Sanja Đekić, Sanja Belić, and Jovana Kos. "State-of-the-art mycotoxin analysis: Insights from LC/MS-MS method." Food and Feed Research, no. 00 (2025): 73. https://doi.org/10.5937/ffr0-55401.

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Mycotoxins are secondary metabolites produced by fungi, known for their chemical and thermal stability, which makes them resistant to common food and feed processing methods. These toxins can contaminate food and feed, and cause a range of toxic effects upon ingestion, including mutagenic, teratogenic, carcinogenic, immunotoxic, neurotoxic, hepatotoxic, and dermatotoxic effects. In recent years, the application of liquid chromatography combined with tandem mass spectrometry has grown significantly for mycotoxin analysis, owing to its remarkable sensitivity and specificity. Recent literature hi

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Gelb, Michael H., Khaja Basheeruddin, Alberto Burlina, et al. "Liquid Chromatography–Tandem Mass Spectrometry in Newborn Screening Laboratories." International Journal of Neonatal Screening 8, no. 4 (2022): 62. http://dx.doi.org/10.3390/ijns8040062.

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Tandem mass spectrometry (MS/MS) is the most universal platform currently available for the analysis of enzymatic activities and biomarkers in dried blood spots (DBS) for applications in newborn screening (NBS). Among the MS/MS applications in NBS, the most common is flow-injection analysis (FIA-) MS/MS, where the sample is introduced as a bolus injection into the mass spectrometer without the prior fractionation of analytes. Liquid chromatography combined with MS/MS (LC-MS/MS) has been employed for second-tier tests to reduce the false-positive rate associated with several nonspecific screeni

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M Pavan Kumar, A Naga Akshay Kumar, D Pooja, M Ahalya, SK Mastan Vali, and Y Yamini. "A comprehensive study on sitagliptin in the treatment of Type-II Diabetes." World Journal of Biology Pharmacy and Health Sciences 20, no. 3 (2024): 120–29. https://doi.org/10.30574/wjbphs.2024.20.3.0988.

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Sitagliptin is an oral antihyperglycemic drug classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor; commonly used in the treatment of type 2 diabetes. It works by promoting insulin secretion and decreasing glucagon levels through the inhibition of incretin degradation in a glucose-dependent manner. As of 2013; it was the second-highest selling medication in the United States. This review highlights various analytical techniques for the quantification of sitagliptin; either alone or in combination with other agents. These methods include spectrometry; high-performance liquid chromatography

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Alder, Lutz, James R. Startin, S. Alonso, et al. "Determination of Chlormequat and Mepiquat in Foods by Liquid Chromatography/Mass Spectrometry or Liquid Chromatography/Tandem Mass Spectrometry: Interlaboratory Study." Journal of AOAC INTERNATIONAL 88, no. 6 (2005): 1762–76. http://dx.doi.org/10.1093/jaoac/88.6.1762.

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Abstract Interlaboratory validation studies have been performed on 2 methods for the determination of chlormequat (CLQ) and mepiquat (MPQ). Both methods used identical extraction procedures and stable isotope internal standardization but differed in the use of liquid chromatography/mass spectrometry (LC/MS) or LC/tandem mass spectrometry (LC/MS/MS) for the determination, the amount of internal standard used, and the expected limit of detection. After addition of deuterated internal standards, CLQ and MPQ were extracted with methanol–water and determined by LC/MS or LC/MS/MS with positive elect

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Pisitkun, Trairak, Jason D. Hoffert, Ming-Jiun Yu, and Mark A. Knepper. "Tandem Mass Spectrometry in Physiology." Physiology 22, no. 6 (2007): 390–400. http://dx.doi.org/10.1152/physiol.00025.2007.

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Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification (“shotgun” proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful tool for the study of cell physiology.

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Prasad, B. Satya. "AN ANALYTICAL REVIEW-BASED STUDY ON SITAGLIPTIN." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 07, no. 10 (2023): 1–11. http://dx.doi.org/10.55041/ijsrem25947.

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Sitagliptin is an oral anti-hyperglycemic agent of the dipeptidyl peptidase-4 (DPP-4) inhibitor magnificence used inside the remedy of type-2 diabetes. It stimulates insulin release and reduces glucagon levels by inhibiting of inactivation of the incretin in a glucose-dependent manner. In 2013 it was the second best- selling drug in the U.S. This evaluation encompasses diverse analytical strategies inclusive of spectrometry, high-overall performance liquid chromatography (HPLC), liquid chromatography-electrospray ionization- mass spectrometry (LC-ESI-MS-MS), liquid chromatography-mass spectrom

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Shounak, Mande*. "A Review Article on Hyphenated Techniques Used in Analytical Method and Development." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2407–17. https://doi.org/10.5281/zenodo.14762916.

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The hyphenated techniques refers to the combination or synthesis of distinct analytical methodologies. Spectroscopic techniques are mostly paired with chromatographic techniques. After that, an interphase will allow the mixture's separated components from the chromatographic approach to enter the spectroscopic technique. In GC-MS After separation from gas chromatography, ionization and mass spectrometry are added to MS. analysis and measurement of the mass-to-charge ratios of the ions that the mass spectrometer generates from each analysis. GC and MS can be connected by a membrane separator, j

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Vanitha Madhuri T, Santhosh Kumar Sorapalli, Kishore Babu Kagitha, et al. "A Review of Liquid Chromatography-Mass Spectrometry and its Applications in Chemical Analysis." Journal of Pharma Insights and Research 2, no. 6 (2024): 025–32. https://doi.org/10.69613/gre1zt18.

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Liquid Chromatography-Mass Spectrometry (LC-MS) has emerged as a powerful analytical technique combining the separation capabilities of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. This sophisticated instrumentation enables precise identification and quantification of complex chemical mixtures across diverse fields including pharmaceuticals, environmental monitoring, food safety, and biological research. Modern LC-MS systems offer enhanced resolution, improved ionization methods, and sophisticated mass analyzers that facilitate accurate molecular weight

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Patel, Nirali G., D. A. Dhale, and Mayuri C. Rathod. "Analysis of Pesticide Residue in Fruit Using the QuEChERS Method Coupled With LC-MS/MS Detection." Current Agriculture Research Journal 12, no. 2 (2024): 865–72. http://dx.doi.org/10.12944/carj.12.2.29.

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Identifying pesticide residues in fruits is essential to both regulatory compliance and food safety. For this use, liquid chromatography combined with tandem mass spectrometry, or liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), is an advanced analytical method that provides excellent sensitivity and specificity. This work offers a thorough procedure for employing LC-MS/MS to extract, clean up, and quantify various pesticide residues in fruit samples.The QuEChERS technique, which uses acetonitrile and a salting-out step for effective partitioning, first homogenizes the fru

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Pang, Bingyao, Ying Zhu, Longqing Lu, Fangbing Gu, and Hailong Chen. "The Applications and Features of Liquid Chromatography-Mass Spectrometry in the Analysis of Traditional Chinese Medicine." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/3837270.

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With increasingly improved separation of complex samples and detection of unknown material capabilities, liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in traditional Chinese medicine (TCM) research. This article describes the principles of liquid chromatography (LC) and mass spectrometry (MS) and their advantages and disadvantages in qualitative and quantitative analysis of TCM. We retrieved research literatures about the application of LC-MS in TCM published during the past five years at home and abroad. To better guide the analysis of TCM, this review main

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Sherma, Joseph. "High-Performance Liquid Chromatography/Mass Spectrometry Analysis of Botanical Medicines and Dietary Supplements: A Review." Journal of AOAC INTERNATIONAL 86, no. 5 (2003): 873–81. http://dx.doi.org/10.1093/jaoac/86.5.873.

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Abstract This article reviews research on the qualitative and quantitative analysis by high-performance column liquid chromatography/mass spectrometry (LC/MS) and LC/tandem mass spectrometry (LC/MS/MS) of botanical drugs, drug substances or preparations, and finished botanical products. In addition, LC/MS and LC/MS/MS techniques and commercial instruments are described and compared briefly, and prospects for future use of these methods for the analysis of botanicals are suggested. Some applications of direct MS without LC are also described.

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Dai, Susie Y. "Tool Box for Product Safety: Modern Chromatography and Mass Spectrometry." Journal of Regulatory Science 3, no. 2 (2016): i—ii. http://dx.doi.org/10.21423/jrs-v03n02pi.

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Modern chromatography coupled with mass spectrometry is a powerful analytical tool to analyze and characterize regulated products based on the physical separation through chromatography and atomic/molecular characterization of the separated analytes. Gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) are particularly applicable to the measurement of complex mixtures, assisted with proper pre-sample treatment. Particularly, LC-MS can be used as a screening, confirmation, and quantification tool for hundreds, or even thousands, of chemical components

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Aubaqnac, J.-L., M. Amblard, C. Enjalbal, et al. "Identification of Synthetic By-products in Combinatorial Libraries Using High Performance Liquid Chromatography-Eiectrospray Ionization Mass Spectrometry." Combinatorial Chemistry & High Throughput Screening 2, no. 5 (1999): 289–96. http://dx.doi.org/10.2174/1386207302666220204200851.

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Abstract: High performance liquid chromatography (HPLC), electrospray ionization mass spectrometry (ESI) and high performance liquid chromatography coupled to mass spectrometry (LC-MS) were used to analyze randomly chosen samples from parallel syntheses carried out on derivatized polypropylene crowns compatible with a Multipin™ solid support system. Side reactions and by-products were clearly identified, and the yields of the expected molecules were unexpectedly low for most samples. LC-MS was superior to HPLC with absorbance detection or electrospray mass spectrometry alone for determining t

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Rathore, Surbhi. "A Review on Liquid Chromatography-Mass Spectrometry (LC-MS)." International Journal for Research in Applied Science and Engineering Technology 13, no. 3 (2025): 844–48. https://doi.org/10.22214/ijraset.2025.67278.

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The hyphenation of liquid chromatography with mass spectrometry allows for the simultaneous analysis of compounds based on their retention times and mass-to-charge ratios, providing valuable information about the identity and quantity of analytes in a sample. One of the key advantages of LC-MS is its versatility, as it can be applied to a wide range of samples including biological fluids, environmental samples, pharmaceuticals, and food products. This makes it an essential technique in fields such as pharmaceutical analysis, environmental monitoring, metabolomics, proteomics, and forensic scie

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CAN, Nafiz. "Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF." Molecules 23, no. 7 (2018): 1771. http://dx.doi.org/10.3390/molecules23071771.

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Avanafil (AVA), one of the most effective drugs prescribed for erectile dysfunction, is a pyrimidine-derivative PDE5 inhibitor. In the current work, new LC methods were developed and validated for quantitative determination of avanafil and qualitative determination of its degradation products. The quantitative determination of avanafil was carried out using liquid chromatography with photodiode array detection (LC-DAD) and liquid chromatography-tandem mass spectrometry LC-MS/MS methods, and fully validated according to the ICH Q2 (R1) guideline, while qualitative determination was performed us

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Vogeser, Michael, and Christoph Seger. "Pitfalls Associated with the Use of Liquid Chromatography–Tandem Mass Spectrometry in the Clinical Laboratory." Clinical Chemistry 56, no. 8 (2010): 1234–44. http://dx.doi.org/10.1373/clinchem.2009.138602.

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BACKGROUND Novel mass spectrometric techniques such as atmospheric pressure ionization and tandem mass spectrometry have substantially extended the spectrum of clinical chemistry methods during the past decade. In particular, liquid chromatography tandem–mass spectrometry (LC-MS/MS) has become a standard tool in research laboratories as well as in many clinical laboratories. Although LC-MS/MS has features that suggest it has a very high analytical accuracy, potential sources of inaccuracy have recently been identified. CONTENT The sources of inaccuracy in LC-MS/MS methods used in the routine q

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Peste, Gabriela, Nela Bibire, Mihai Apostu, Aurel Vlase, and Corneliu Oniscu. "A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples." Journal of Biomedicine and Biotechnology 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/736327.

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Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. The advantages of using LC/MS methods over HPLC methods include: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has pro

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Carling, Rachel S., Benjamin AC McDonald, Donna Austin, et al. "Challenging the status quo: A comparison of ion exchange chromatography with liquid chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry methods for the measurement of amino acids in human plasma." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 4 (2020): 277–90. http://dx.doi.org/10.1177/0004563220933303.

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Background Plasma amino acid analysis is key to the diagnosis and monitoring of inherited disorders of amino acid synthesis, catabolism and transport. Ion exchange chromatography (IEC) is widely accepted as the gold standard method of analysis, but with the introduction of liquid chromatography tandem mass spectrometry (LC-MS/MS) and liquid chromatography mass spectrometry (LC-MS) methods, this should now be questioned. Methods The analytical performance of three commercially available reagent kits, Waters AccQ Tag™ ULTRA LC-MS, SpOtOn Amino Acids LC-MS/MS and Chromsystems MassChrom® Amino Aci

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Loftus, Neil. "Gold standard: Mass spectrometry and chromatography." Biochemist 24, no. 1 (2002): 25–27. http://dx.doi.org/10.1042/bio02401025.

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Mass spectrometry (MS) interfaced with liquid chromatography (LC) was once considered a technology that was reserved for rather specific applications that appeared to work in sequence with the phases of the moon. Early adventures with thermospray and particle beam interfaces proved to be of limited use, and it was not until atmospheric pressure ionization established itself that we could regard LC–MS as the analytical tool of choice for a considerable range of challenges. Indeed, advances in source design and increased ion transmission have presented a new generation of instruments that use hy

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Omelchun, Y., and A. Kobish. "Modern methods for the determination of pesticide residues in beekeeping products and for the diagnostics of bee poisoning." Naukovij vìsnik veterinarnoï medicini, no. 2(176) (December 27, 2022): 101–10. http://dx.doi.org/10.33245/2310-4902-2022-176-2-101-110.

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Intensification of agricultural production is associated with the use of a significant amount of pesticides, which negatively affects the environment and human health, and food products, including beekeeping products, accordingly require mandatory control of residual amounts of pesticides. This article provides a comparative analysis of the available chromatographic methods for pesticide residue research. The necessity of using modern chromatographic methods to determine residual amounts of pesticides in samples of dead bees and beekeeping products is well-founded. Chromatographic methods of s

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Mol, Hans G. J., Ruud C. J. Van Dam, Rob J. Vreeken, and Odile M. Steijger. "Determination of Chlormequat in Pears by Liquid Chromatography/Mass Spectrometry." Journal of AOAC INTERNATIONAL 83, no. 3 (2000): 742–47. http://dx.doi.org/10.1093/jaoac/83.3.742.

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Abstract A straightforward and reliable method was developed for the determination of chlormequat in pears by liquid chromatography/mass spectrometry (LC/MS). Water and methanol were compared as extraction solvents. Because no significant differences in extraction efficiency or repeatability were found, water was chosen as the extraction solvent. The extracts were analyzed without cleanup by either an ion-trap liquid chromatograph/mass spectrometer in the single MS mode or a triple-quadrupole instrument in the MS/MS mode, using electrospray ionization. Both instruments were equally suitable fo

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Yokley, Robert A., Nanzhu Shen, and Max W. Cheung. "Determination of Two Oxy-Pyrimidine Metabolites of Diazinon in Urine by Gas Chromatography/Mass Selective Detection and Liquid Chromatography/Electrospray Ionization/Mass Spectrometry/Mass Spectrometry." Journal of AOAC INTERNATIONAL 83, no. 5 (2000): 1229–38. http://dx.doi.org/10.1093/jaoac/83.5.1229.

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Abstract An analytical method was developed for the determination in urine of 2 metabolites of diazinon: 6-methyl-2-(1-methylethyl)-4(1H)-pyrimidinone (G-27550) and 2-(1-hydroxy-1-methylethyl)-6-methyl-4(1H)-pyrimidinone (GS-31144). Two of the urine sample preparation procedures presented rely on gas chromatography/mass selective detection (GC/MSD) in the selected ion monitoring mode for determination of G-27550. For fast sample preparation and a limit of quantitation (LOQ) of 1.0 ppb, urine samples were purified by using ENV+ solid-phase extraction (SPE) columns. For analyte confirmation at a

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T. Farmaan, C. Hima Bindu, and T. Reshma. "LC-MS in Proteomics and Biomarker Discovery." International Journal of Science and Research Archive 14, no. 3 (2025): 900–913. https://doi.org/10.30574/ijsra.2025.14.3.0753.

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Liquid chromatography-mass spectrometry (LC-MS) has emerged as a powerful analytical tool in the field of proteomics and biomarker discovery. LC-MS combines the high separation efficiency of liquid chromatography (LC) with the sensitive and specific detection capabilities of mass spectrometry (MS), enabling the identification and quantification of complex protein mixtures in biological samples. In proteomics, LC-MS facilitates the characterization of post-translational modifications, protein-protein interactions, and differential protein expression in health and disease states. The technique's

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Milicevic, Dragan, Verica Juric, Srdjan Stefanovic, Slavica Veskovic-Moracanin, and Sasa Jankovic. "Analysis of ochratoxin A in pig tissues using high pressure liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC/MS/MS) as confirmative methods." Zbornik Matice srpske za prirodne nauke, no. 117 (2009): 51–61. http://dx.doi.org/10.2298/zmspn0917051m.

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Two different analytical methods for the determination and confirmation of ochratoxin A (OTA) in blood serum, kidney and liver of pigs have been compared. Sample clean-up was based on liquid-liquid phase extraction. The detection of OTA was accomplished with high-performance liquid chromatography (HPLC) combined either with fluorescence detection (FL) or electro spray ionization (ESI+) tandem mass spectrometry (MS-MS). Comparative method evaluation was based on the investigation of 82 samples of blood serum, kidney and liver originating from different regions of Serbia. The analytical results

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Alfazema, Louisa N., Don S. Richards, Sylvie Gélébart, John C. Mitchell, and Martin J. Snowden. "Rapid, Accurate and Precise Quantitative Drug Analysis: Comparing Liquid Chromatography Tandem Mass Spectrometry and Chip-Based Nanoelectrospray Ionisation Mass Spectrometry." European Journal of Mass Spectrometry 11, no. 4 (2005): 393–402. http://dx.doi.org/10.1255/ejms.772.

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We have developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) system capable of achieving better than 2% accuracy, routinely over a wide concentration range of 1–800 ng mL−1. We demonstrate that the necessary high precision, high accuracy and rapid analysis can be achieved using LC-MS/MS technology. Automated nanoelectrospray ionisation tandem mass spectrometry (nanoESI-MS/MS) technology can be employed to eliminate the chromatographic step completely. In this paper, nanoESI-MS/MS is evaluated and compared directly with LC-MS/MS for the quantitative analysis of two-test analyte

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Fitzgerald, Robert L., Jeffrey D. Rivera, and David A. Herold. "Broad Spectrum Drug Identification Directly from Urine, Using Liquid Chromatography-Tandem Mass Spectrometry." Clinical Chemistry 45, no. 8 (1999): 1224–34. http://dx.doi.org/10.1093/clinchem/45.8.1224.

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Abstract Background: Currently the rate-limiting step for mass spectrometric analysis of drugs in biological samples is sample preparation. Many gas chromatography/mass spectrometry (GC/MS) methods are specific for a certain class of compounds, requiring extraction and/or derivatization before analysis. The purpose of this study was to develop a broad spectrum liquid chromatography/mass spectrometry (LC/MS) procedure that allowed for direct analysis of urine specimens with potential for quantitative analysis. Methods: We modified a commercially available column-switching instrument, the REMEDi

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Dioquino, Carissa Paz, and Roy Roberto Gerona. "A critical review of drug testing policy in the Philippines." Drug Science, Policy and Law 8 (January 2022): 205032452210981. http://dx.doi.org/10.1177/20503245221098161.

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The drug policy in the Philippines is written as the Comprehensive Dangerous Drugs Act of 2002 or Republic Act 9165. Unlike drug policies in other countries, the law includes policies on drug testing. Aside from mandatory drug testing for specific situations, the law states further that two testing methods should be employed—a screening test, and a confirmatory test to be performed if the former yields a presumptive positive result. Over 1000 drugs of abuse screening laboratories are scattered all over the Philippines, but only seven can perform confirmatory testing using either gas chromatogr

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Zimmer, D. "Introduction to quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS)." Chromatographia 57, S1 (2003): S325—S332. http://dx.doi.org/10.1007/bf02492124.

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Song, Ki-Cheol, Ka-Jeong Lee, Ji-Hoe Kim, Ho-Dong Yoon, Hong-Sik Yu, and Jong-Soo Mok. "Tetramine Analysis using Liquid Chromatography-Tandem Mass Spectrometry and Ion Chromatography." Korean Journal of Fisheries and Aquatic Sciences 44, no. 1 (2011): 45–49. http://dx.doi.org/10.5657/kfas.2011.44.1.045.

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Praseed, Sarkar1* Pritam Sarkar1 Suraj Saha1 Mandakini Devi Hanjabam2. "LC-MS/MS Method for Detecting Antibiotic Residues in Seafood Products." Science world a Monthly e magazine 5, no. 5 (2025): 7133–41. https://doi.org/10.5281/zenodo.15518175.

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Since 1950s world aquaculture production has grown rapidly all around the world. In the year 2022, for the first time world aquaculture production has reached up to 130.9 million tons surpassing capture fisheries (FAO, 2024). Antibiotics play a critical role in food security and animal welfare, as they are used to combat infectious diseases. The misused of antibiotics increases the risk of antimicrobial resistance in animal thereby impacting the effectiveness of antibiotics in the treatment of disease (Santos and Ramos, 2018). Another serious issue of misusing antibiotics is that they cause se

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Neuhof, Torsten, Robert Köppen, Matthias Koch, and Irene Nehls. "Letter: High-Performance Liquid Chromatography/Electrospray Mass Spectrometry Analysis of the Mycotoxin Aurofusarin." European Journal of Mass Spectrometry 14, no. 5 (2008): 329–33. http://dx.doi.org/10.1255/ejms.935.

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High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) can be used for simultaneous quantification of various mycotoxins in contaminated food samples. Therefore, multi-mycotoxin methods have been developed in the last couple of years. To enlarge these methods for further analytes, we have developed a LC-MS/MS method for the quantification of the mycotoxin aurofusarin. Additionally, further LC-MS n experiments were performed to demonstrate the fragmentation pattern of aurofusarin. Applicable multiple reaction monitoring (MRM) transitions of aurofusarin were found and optim

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Bladek, Tomasz, Andrzej Posyniak, and Jan Zmudzki. "Determination of tulathromycin in swine tissues by liquid chromatography-tandem mass spectrometry." Anal. Methods 6, no. 17 (2014): 6745–52. http://dx.doi.org/10.1039/c4ay01165a.

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Andrensek, Samo, Alenka Golc-Wondra, and Mirko Prosek. "Determination of Phenylalanine and Tyrosine by Liquid Chromatography/Mass Spectrometry." Journal of AOAC INTERNATIONAL 86, no. 4 (2003): 753–58. http://dx.doi.org/10.1093/jaoac/86.4.753.

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Abstract Phenylketonuria is a common metabolic disorder disease. Those affected appear normal at birth, but without treatment they develop severe psychomotor retardation. Throughout life, they must control their blood levels of phenylalanine (Phe) and consume a diet containing adequate amounts of Phe and tyrosine (Tyr). We have developed a liquid chromatographic/mass spectrometric (LC/MS) method for the quantitative evaluation of Phe and Tyr in food samples. This method takes advantage of the good separation of LC and the selective and reliable quantification provided by MS in the electrospray

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Sosa-Ferrera, Zoraida, Cristina Mahugo-Santana, and José Juan Santana-Rodríguez. "New Developments in Liquid Chromatography Mass Spectrometry for the Determination of Micropollutants." Chromatography Research International 2012 (December 17, 2012): 1–18. http://dx.doi.org/10.1155/2012/748989.

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The combination of liquid chromatography (LC) with mass spectrometry (MS) in the environmental field has appeared as a valuable tool for the determination of micropollutants. Several groups of compounds have been considered as particularly relevant (e.g., pharmaceuticals, hormones and other endocrine-disrupting, personal care products and their metabolites, flame retardants, surfactants, and plasticizers, among others) since the same ones are continuously being released in the environment mainly as a result of the manufacturing processes, the disposal of unused or expired products, and the exc

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Beccaria, Marco, and Deirdre Cabooter. "Current developments in LC-MS for pharmaceutical analysis." Analyst 145, no. 4 (2020): 1129–57. http://dx.doi.org/10.1039/c9an02145k.

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Liu, Yang, Jianghai Lu, Sheng Yang, Youxuan Xu, and Xiaobing Wang. "A new potential biomarker for 1-testosterone misuse in human urine by liquid chromatography quadruple time-of-flight mass spectrometry." Analytical Methods 7, no. 11 (2015): 4486–92. http://dx.doi.org/10.1039/c5ay00658a.

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In this study, 1-testosterone urinary metabolic profiles were investigated by liquid chromatography quadruple time-of-flight mass spectrometry (LC-QTOF-MS) using full scan and targeted MS/MS techniques with accurate mass measurement.

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Nagai, Hiroyuki, Tomiaki Minatani, and Kotaro Goto. "Development of a Method for Crustacean Allergens Using Liquid Chromatography/Tandem Mass Spectrometry." Journal of AOAC INTERNATIONAL 98, no. 5 (2015): 1355–65. http://dx.doi.org/10.5740/jaoacint.14-248.

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Abstract An LC/MS/MS analysis method was developed for crustacean allergens, tropomyosin, and arginine kinase. A protein extract from shrimp was reduced, alkylated, and digested by trypsin. Peptide spectra were obtained using full scan analysis by LC/MS/MS, and we determined a sequence through a protein search. 22ADTLEQQNK30, 92IQLLEEDLER101, 113LAEASQAADESER125, 134SLSDEER140, 153FLAEEADR160, and 190IVELEEELR198 of tropomyosin and 152VSSTLSSLEGELK164 and 217TFLVWVNEEDHLR229 of arginine kinase were selected as the specific peptides, and optimal multiple-reaction monitoring conditions were used

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Banerjee, Upamanyu, and Ulisses M. Braga-Neto. "Bayesian ABC-MCMC Classification of Liquid Chromatography–Mass Spectrometry Data." Cancer Informatics 14s5 (January 2015): CIN.S30798. http://dx.doi.org/10.4137/cin.s30798.

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Proteomics promises to revolutionize cancer treatment and prevention by facilitating the discovery of molecular biomarkers. Progress has been impeded, however, by the small-sample, high-dimensional nature of proteomic data. We propose the application of a Bayesian approach to address this issue in classification of proteomic profiles generated by liquid chromatography-mass spectrometry (LC-MS). Our approach relies on a previously proposed model of the LC-MS experiment, as well as on the theory of the optimal Bayesian classifier (OBC). Computation of the OBC requires the combination of a likeli

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Lee, J. H., J. Y. Choi, H. Park, et al. "Development and validation of Q-TOF/MS method for the rapid and simultaneous quantification of three aconitum alkaloids in food." Analytical Methods 7, no. 18 (2015): 7733–40. http://dx.doi.org/10.1039/c5ay01316j.

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In this study, the presence of three aconitum alkaloids (aconitine, mesaconitine, and hypaconitine) in food was determined by liquid chromatography-tandem mass spectroscopy (LC-MS/MS) and quadruple time of flight mass spectrometry (Q-TOF/MS).

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Stout, Steven J., Enaksha Wickremesinhe, Adrian R. daCunha, and Alisa Khunachak. "Confirmation of Moxidectin Residues in Cattle Fat by Liquid Chromatography/Mass Spectrometry." Journal of AOAC INTERNATIONAL 83, no. 6 (2000): 1446–50. http://dx.doi.org/10.1093/jaoac/83.6.1446.

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Abstract Moxidectin, a potent new endo- and ectoparasitic agent, is determined in cattle tissues by liquid chromatography (LC) with fluorescence detection. The original confirmatory method for moxidectin in cattle fat, the target tissue for regulatory purposes, was LC with mass spectrometry (MS) using thermospray (TSP) ionization and selected ion monitoring. As newer ionization techniques for LC/MS made TSP obsolete and with the availability of a new generation of benchtop LC/MS instrumentation, the confirmation of moxidectin in cattle fat was re-evaluated. The ionization techniques of atmosph

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Sun, Jiayi, Beibei Liu, Liangzhao Cai, Jia Yu та Xingjie Guo. "Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development with β-cyclodextrin (β-CD) derivatized chiral stationary phase for the enhanced separation and determination of flurbiprofen enantiomers: application to a stereoselective pharmacokinetic study". New Journal of Chemistry 44, № 25 (2020): 10334–42. http://dx.doi.org/10.1039/d0nj01516d.

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Strazisar, Monika, Maja Fir, Alenka Golc-Wondra, Luka Milivojevic, Mirko Prosek, and Veronika Abram. "Quantitative Determination of Coenyzme Q10 by Liquid Chromatography and Liquid Chromatography/Mass Spectrometry in Dairy Products." Journal of AOAC INTERNATIONAL 88, no. 4 (2005): 1020–27. http://dx.doi.org/10.1093/jaoac/88.4.1020.

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Abstract The dietary sources of CoQ10 and the evaluation of CoQ10 in dairy products were characterized. For quantitation of CoQ10 in food samples, 2 liquid chromatography (LC) methods with UV and mass spectrometry (MS) detections were developed. LC with UV detection was performed at 25°C on a Hyperclone ODS 5 μm 150 × 4.6 mm column with mobile phase consisting of methanol-ethanol-2-propanol (70 + 15 + 15, v/v/v). Flow rate was 1.0 mL/min. Retention time of CoQ10 was 10.9 ± 0.1 min. The method was sensitive [limit of detection (LOD) = 0.2 mg/kg], reproducible [relative standard deviation (RSD)

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Prenni, Jessica E., Zhouxin Shen, Sunia Trauger, Wei Chen, and Gary Siuzdak. "Protein characterization using Liquid Chromatography Desorption Ionization on Silicon Mass Spectrometry (LC-DIOS-MS)." Spectroscopy 17, no. 4 (2003): 693–98. http://dx.doi.org/10.1155/2003/172838.

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This paper presents a novel combination of of-line liquid chromatography (LC) separation with desorption ionization on silicon mass spectrometry (DIOS-MS) as an alternative to the traditional on-line coupling of LC and electrospray ionization (ESI). In this work, electrospray deposition is used to generate a spatially preserved linear track of the separated sample on a specially designed DIOS chip. The total sequence coverage analysis of two model protein systems was evaluated by both LC-DIOS-MS and nanoLC ESI tandem MS (MS/MS). LC-DIOS-MS yielded improved sequence coverage for both of the mod

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Dang, Trung Dung, Nguyen Thuy Trang, Nguyen Thi Xuan Quynh, Nguyen Lan Huong, and La Duc Duong. "Electrochemical sensor determines antibiotic residues of Chloramphenicol in fresh milk using modified Glassy carbon electrode based on nZVI/GNPs/TCPP nanocomposite material synthesized by green chemistry method." Vietnam Journal of Catalysis and Adsorption 12, no. 2 (2024): 1–6. http://dx.doi.org/10.62239/jca.2024.025.

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Chloramphenicol (CAP) is a broad-spectrum antibiotic widely used in medicine and agriculture since 1948 [1]. Currently, CAP is banned due to its potential health hazards [2]. Therefore, detecting antibiotic residual levels of CAP in food is necessary. The electrochemical method, characterized by its simplicity, speed, high sensitivity, ease of on-site analysis, and low cost, demonstrates potential in assessing antibiotic residual CAP compared to traditional methods such as liquid chromatography-mass spectrometry (LC-MS), liquid chromatography-electrochemical ionization-mass spectrometry (LC-EI

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Antolčić, Mia, Mislav Runje, and Nives Galić. "A simple and sensitive LC-MS/MS method for determination and quantification of potential genotoxic impurities in the ceritinib active pharmaceutical ingredient." Analytical Methods 12, no. 25 (2020): 3290–95. http://dx.doi.org/10.1039/d0ay00511h.

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Zhao, Xiaoping, Liping Kang, Taichang Zhang, et al. "Rapid quantification of a chemically synthesized peptide GAP162 in rat plasma by liquid chromatography/triple quadrupole tandem mass spectrometry and application to a pharmacokinetic study." RSC Advances 5, no. 64 (2015): 51708–16. http://dx.doi.org/10.1039/c5ra05188f.

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Lesne, Jean, Marie-Pierre Bousquet, Julien Marcoux, and Marie Locard-Paulet. "Top-Down and Intact Protein Mass Spectrometry Data Visualization for Proteoform Analysis Using VisioProt-MS." Bioinformatics and Biology Insights 13 (January 2019): 117793221986822. http://dx.doi.org/10.1177/1177932219868223.

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The rise of intact protein analysis by mass spectrometry (MS) was accompanied by an increasing need for flexible tools allowing data visualization and analysis. These include inspection of the deconvoluted molecular weights of the proteoforms eluted alongside liquid chromatography (LC) through their representation in three-dimensional (3D) liquid chromatography coupled to mass spectrometry (LC-MS) maps (plots of deconvoluted molecular weights, retention times, and intensity of the MS signal). With this aim, we developed a free and open-source web application named VisioProt-MS ( https://massto

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Roškar, Robert, and Marija Dolenc. "Determination of Benzodiazepines in Urine Via Benzophenone Derivatives Using Liquid Chromatography-Tandem Mass Spectrometry." Archives of Industrial Hygiene and Toxicology 61, no. 4 (2010): 381–88. http://dx.doi.org/10.2478/10004-1254-61-2010-2058.

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Determination of Benzodiazepines in Urine Via Benzophenone Derivatives Using Liquid Chromatography-Tandem Mass SpectrometryThe aim of this study was to validate a new method for determining benzodiazepines in urine via their benzophenone derivatives, based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). Selected benzodiazepines were analysed after acid hydrolysis of urine and extraction by ethyl acetate in the presence of an internal standard. Samples were analysed using electrospray ionization LC-MS/MS in a multiple reaction monitoring mode. The chromatographic run time on a rev

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Grassi, Giorgia, Elisa Polledri, Silvia Fustinoni, et al. "Hyperandrogenism by Liquid Chromatography Tandem Mass Spectrometry in PCOS: Focus on Testosterone and Androstenedione." Journal of Clinical Medicine 10, no. 1 (2020): 119. http://dx.doi.org/10.3390/jcm10010119.

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The identification of hyperandrogenism in polycystic ovary syndrome (PCOS) is concerning because of the poor accuracy of the androgen immunoassays (IA) and controversies regarding which androgens should be measured. The aim of our study was to evaluate the impact of the assessment of testosterone (T) and androstenedione (A) by liquid chromatography in tandem with mass spectrometry (LC/MS-MS), in the diagnosis of PCOS. We evaluated 131 patients referred for suspected PCOS. Fourteen patients in total were excluded, some because of other diagnosis (n = 7) or incomplete diagnostic workup (n = 7).

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