Teses / dissertações sobre o tema "Médiation thérapeutique"
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Hyon, Jungsin. "Méditation et médiation thérapeutique : Aspects théoriques et cliniques". Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR2030.
Texto completo da fonteGiven the widespread and widespread misunderstandings about this practice and given that the spiritual tradition is seen as elusive, it is important to discern the boundary between the beneficent and the harmful uses in meditation. In order to do this, by combining psychometric tools with clinical experimentation, this research has studied the effectiveness of meditative practice from the therapeutic point of view, in order to reveal the probability to find a link and to understand and the correlation between the psychotherapeutic effect of meditation and psychosomatic conversion - being at the frontier of empiricism and spiritualism.So, the present thesis is divided into two parts: the first part deals with the theory of meditative practice based on theoretical data, while the second part deals with the modeling of this practice, based on empirical data. On the theoretical level, this research begins with the idea that what is called “Jouissance mystique (mystical enjoyment)” can lead to a psychopathological structure, when the subject is placed in the feminine position as an agalmatic object.Based on these theoretical data, a study has been carried out, with the aim of achieving a scientific validity, a practical modeling of these ideas, based on empirical data. This part of the studywas necessary to verify the efficiency of the interventions and the improvement of the symptoms experienced by the patients, from a clinical point of view.In this perspective, the clinical investigation of this research is based on the application of clinico-psychological methods, derived from the integration of complementary and alternative treatments to psychosomatic intervention. By specifying that the collection of empirical data is based on the application of five rating scales, namely: Rome III Diagnostic Criteria; Quality of Life SF-36; Fatigue Impact Scale; Symptom Checklist-90-R; And Minnesota Multiphasic Personality Inventory- 2
Chocron, Michael. "Fonctionnements autistiques et dimension thérapeutique des médiations". Paris 13, 2012. http://www.theses.fr/2012PA131020.
Texto completo da fonteCare for subjects with autistic or related disorders in medical institutes is mainly based on activities using mediation. This research deals with the caring of youngsters with Pervasive Developmental Disorder in a medical institute. Using both autobiographical work from author with autism and case study of psychotherapeutic follow-up in a medical institute, the idea of autistic functioning will be exposed. This idea is a way to comprehend psychic process mostly seen in autistic persons. In addition to this theoretical point of view about autism, this work contains observation and theorisation of three apparatus usually used in medical institutes (a walking activity, a sexual education activity and a journal activity). The observations of educative, sportive and cultural apparatus are analysed using psychoanalytical group theory. This research outlines qualitative aspects of mechanisms seen in those apparatus that helps patients to find a therapeutic profit. Using group activity, diversity of the apparatus, and their integration inside a global caring project are ways to stimulate autistic subject to avoid set up or perseveration of sameness. Social integration is also addressed from an institutional level resorting on peer groups and using apparatus to encounter with society outside the institute. Key-words: Autism, mediation, psychotherapy, group clinic, institutional therapy
Thomas, Alain. "Groupe thérapeutique à médiation corporelle et intégration comportementale du sujet autistique : suivi longitudinal et analyse des traits comportementaux". Amiens, 2008. http://www.theses.fr/2008AMIE0027.
Texto completo da fonteSabot, Magalie. "Du collage au « photocollage » : une médiation thérapeutique revisitée en clinique hospitalière". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC238.
Texto completo da fonteThis work offers to consider the position of photographic art within the clinical psychology practice. Are the images used in clinical sessions merely reproducing the trauma, or could they inspire creation? How can these images be used in clinical sessions? Such are the deeply contemporary questions to which this thesis attempts to answer. In order to grasp this question, the thesis immerges into the art of collage, a subjective creative art form using photographic media. The art of collage (to glue in French) seems to allow an antagonistic deepening of perspective from the subject, along with fabulous creations and unseen associations of ideas. Surrealist artists have freely inspired themselves from psychoanalytical concepts in their work; however clinical psychologists have seldom explored the world of art. This thesis attempts to bring together in harmony clinical work, history of art and psychoanalytical theory. « Photocollage » in french refers to this form of mediation, inspired by techniques and theories used by collage artists for individual therapeutic sessions, amid somatic treatment often following trauma.Through these creative processes, we have discovered an intuitive use of collage inorder to overcome extreme trauma. This thesis attempts to explain the reasons and underlying mechanisms. This work examines emerging theories on the subject, and attempts to apply them to therapeutic experience through four highly unique clinical psychology sessions, in order to examine the creative potential of this extraordinary art
Guenoun, Tamara. "La médiation thérapeutique par le théâtre avec les adolescents : Analyse du dispositif clinique et de sa thérapeutique". Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC069.
Texto completo da fonteBased on the observation of groups of teenagers, this study aims to analyze the psychodynamic action of drama -therapy with adolescents. In order to do this, it first highlights the type of psychological processes that role-playing involves for professional actors. It then compares the actor's creative process with the observation of clinicat aspects in groups of teenagers. Thus, we consider four interrelated axes,The first axis is the "container" rote of the stage. With adolescents, the drama-therapy setting implies a specific group dynamic, where the stage has a significant role. This study enables us to explore the relevance of the presence of their peers for self-construction at this age. Paradoxically, playing in front of others gives the opportunity to every teenager to connect with his subjectivity. Secondly, as with professional actors, the body language that theater creates helps adolescents engage with their instinctual and emotional bodies, allowing them to symbolize a previously unelaborated sensoriality. Thirdly, playing in front of others is a central axis of drama-therapy, This training is what leads teenagers to explore reflexivity in intersubjectivity, The analysis of the fluctuations of intersubjectivity can enrich our understanding of adolescent psychopathology, Finally, the psychotherapeutic process happens through role-playing. From a psychological point of view, embodying a character helps to construct an imaginary ego, allowing an authentic expression of the self. Acting on stage to be someone else creates a space for teenagers to figure out who they really are. The theatrical game helps to define more precisely the différent aspects of subjectivity
Basset, Alice. "Le Surmoi dévisagé : Une modélisation théorico-clinique de la praxis du masque comme médiation thérapeutique". Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://theses.univ-cotedazur.fr/2023COAZ2014.
Texto completo da fonteThe Superego is a two-sided instance: it embodies both the necessary symbolic castration to which the Subject must consent in order to be included in the order of desire - the oedipal Superego ; and the imperative of pleasure that cancels out the Subject in order to make it an assignable object - the archaic Superego. It is therefore in two antagonistic directions that the Superego pulls the Subject, between Desire and Pleasure, two pivotal concepts of the psychoanalytical reference frame. Our work questions the way in which the Superego can be involved, and possibly reworked, in the context of a mediation passing through the mask-object. We argue that the latter constitutes both a support of incarnation and destitution of the archaic superego as well as of the injunction to pleasure that it conveys. In the light of several fields of clinical applications and the specificities that emerge from these, it will be a question of modelling more widely the mental parameters regarding the trajectory that this mediation object makes the Subject take in this process. A path then seems to take shape, having at its entry point the ignorance of the Ego during the initial phase of plastic creation -and then forming itself, during the stage improvisation with the previously created mask, as a "staggering crossroads" at the junctions of several and often contradictory psychic movements. The stage of embodying the mask thus plunges the protagonist into a movement of staggering summoning, by which he is confronted with his own question. Finally, there are two ways out of this staggering crossroads at the unmasking stage: that of a return to a new form of ignorance; or that of de-sideration, which is also that of desire. In this we can argue that the praxis of the mask offers the Subject a renewed opportunity to take in the loss that his Ego had until then ignored
Paul, Anne-Marie. "Danse et subjectivation à l'adolescence : de la danse dans la culture à la danse comme médiation thérapeutique". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC065.
Texto completo da fonteDance is a taboo, paradoxical art, and is naturally therapeutic in adolescence – as is play for the child. In reaction to the turmoil of puberty, expressing the dancing impulse favours narcissistic reassurance through the auto-eroticism of danced movement, which summons the archaic identification with the mother’s body, the passivity which is proper to the feminine, and the discovery of the “other sex”. This research work aims on one hand at thinking through culture’s modern enthusiasm for dance, whether artistic or as a leisure pursuit, as one of the new forms of expression of the social bond and what (with Freud) we could call “civilized sexual morality”, taking up a collective feminine eroticism whilst organizing it as a symbolic expression in order to create new territories of the political. It also aims at affirming that a certain form of dance therapy, which I shall call mediation dance, belongs to the psychoanalytic field, so as to support the place of psychoanalysis in the treatment of pathologies in contempo-rary clinical practice, and to envisage adapting its techniques to current modalities of the ex-pression of subjectivity (of which adolescence, as the ultimate case, is the paradigm). The clinical material comprises written and filmed documents, analysis of my group therapy prac-tice, and psychotherapeutic interviews.From an anthropological point of view, classical dance appears to be an attempt to mas-ter the overflowing Eros of Dionysian dance; in contrast, free dance, which emerged in the west at the same time as psychoanalysis, aims to unveil the truth of desire through seeking the natural gesture. While it achieves an “other” jouissance, improvised dance (whether urban or contem-porary) is in fact a transitional experience which, in the very dance movement representing birth, allows the subject to experience separation and to move to the inter-subjective encounter which guarantees intra-subjective construction. A group of dancers is a crowd organized by the aesthetic ideal of rhythm, and can thus appear as an essential form of the group and a priv-ileged place of subjectivation for the contemporary adolescent, who finds a place to satisfy his/her need for collective identification and initiation rituals which leave the imprint of culture on the body. In this way dance can be thought of, with psychoanalysis, as a therapeutic medi-ation which is particularly indicated for adolescents suffering from serious narcissistic pathol-ogies. The study of a mediation group associating dance and writing in an outpatient unit shows how improvised dance, like a “danced squiggle” reveals to patients their unconscious body image, which is transformed in transference through contact with therapists and the group. For these adolescents with symbolisation problems, writing supports the subjectivising properties of dance which are deployed in the meeting space
Gaboriau, Rénald. "Les ateliers Rob'Autisme : Le robot extension comme médiation thérapeutique auprès des personnes présentant un trouble du spectre autistique". Thesis, Ecole centrale de Nantes, 2020. http://www.theses.fr/2020ECDN0016.
Texto completo da fonteThe use of robots as a therapeutic mediator for peolple with Autism Spectrum Disorder (ASD) is a topic which tends to develop. Indeed, it is a promising method to promote the development of social skills. Many experiments are carried out currently. But in all existing approaches, the companion robot paradigm is used : the robot is programmed to present some pre-established behaviors. Rob’Autism Project propose an alternative approach : the robot is used as an extension for doing or talking things. The autistic subjects program it and therefore act on the social environment freely. This project includes ideas that they will be able to interact with the others without the robot. This thesis aims to understand the interest of this approach and asses the effects of participation on the social interactions. During two years, groups have been set up and analyzed with quantitative and qualitative methods. These analysis show that this approach favors the tendency to go towards the others and interact with them. This result is generalized outside the group
Osiurak, François. "Etude neurologique des rapports entre outil, geste et usage". Angers, 2007. http://www.theses.fr/2007ANGE0030.
Texto completo da fonteThe investigation of object use impairement raises the question of the nature of psychological enabling the ability to use tools. It has suggested that this disorder might result from excutive deficts and/or the inability to retrieve sensory motor knowledge about object manipulation (i. E. , gesture engrams). Since manufactured objects are always designed to a specific conventional purpose, it has also been assumed that patients with objet use impairemnt might suffer from detective conceptual knowledge about object function. The present thesis proposes an alternative view by suggesting the object use depends upon a specific technical, rational and implicit ability to analyse natural activity. To contribute to the discussion, we address many epistemological and theoretical issues about the definition of human tool, and report four studies with brain-damaged patients that aimed to examine the relevance of the concepts of "tool", "gesture" and "usage". In sum, the present thesis suggests that the investigation of object use impairement would gain by conceiving this disorder as a singular inability to use tools
Gaillard, Jean-Philippe. "Etude structurale et fonctionnelle du récepteur de l'interleukine-6 : interactions moléculaires dans la médiation du message IL-6". Montpellier 2, 1994. http://www.theses.fr/1994MON20275.
Texto completo da fonteRoyol, Jean-Pierre. "Statut de l'objet et médiation picturale dans le travail avec des enfants psychotiques". Lyon 2, 2000. http://theses.univ-lyon2.fr/documents/lyon2/2000/royol_jp.
Texto completo da fonteFor any psychotic patient, a few elements of the neurotic personality remain inside them like an object. The picture-mediation allows them to reinstate the actual experience through an artistic domain and consequently to reorganize their feelings by creating a relationship between an object and themselves as a subject. This assomption is checked on reality through a clinical experiment carried out through a picture-mediation workshop welcoming psychotic children as well as an analysis of work by the artist Gabriel Guez Ricord. The picture-mediation allows areal experiment on the object in so far as the latter separates from the subject. It il actually by keeping the object at a distance and then by showing it to them a number of times that building a relation in transference and counter-transference is possible in psychotherapy. If the object/subject relation can develop through such a type of mediation and enables us to face the violence of the psychotic object in better conditions, the violence or those archaic representations finds itself too after repressed after evocation with the peculiar texture of the material which is used
Guinard, Frédérik. "Psychopathologie des processus d'appropriation à l'âge de latence : intérêt thérapeutique des groupes à médiation dans la clinique des apprentissages". Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE2104.
Texto completo da fonteThis research finds its origin in a daily clinical practice with children in latence period in treatment for their learning disabilities. The latence period is an important stage of cognitive reorganization and drive defusion. If the learning disabilities and the academic failure can find their origin in older times of the psychic and cognitive development of the subject, the time of latence period is crucial for the growth of the intellectual curiosity and achieve important symbolic “conquests”. Deep, unresolved psychic issues can perturb all modes of abstraction and symbolic understanding as well as causing difficulties in the acquisition of reading and writing. This dissertation explore the various meanings of the anti-learnings conducts which develop these children in their experiences of appropriation, exploration and manipulation of the environment. Finally, this work presents a tool of clinical analysis and qualitative evaluation of the groups of therapeutic mediation which are proposed to treat these context of learning disorder. The therapeutic interest of these settings will be questioned and illustrated through three experiences of group : a workshop with sensory mediation, a painting group experience and a therapeutic group with the medium of theater
Journot, Julie. "L'émancipation des patient·es par l'éducation thérapeutique : approche info-communicationnelle des usages d'une plateforme numérique de médiation des savoirs médicaux". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCH003.
Texto completo da fonteThis CIFRE thesis, carried out within a healthcare start-up, proposes an infocommunicational approach to the phenomena of emancipation of people categorised as obese through digital therapeutic education systems. More specifically, our study aims to analyse the uses of a digital platform for mediating medical knowledge, focusing on its educational aspect and the community possibilities it offers. We are looking specifically at the reception and commitment of patients connected to this tool. We seek to understand whether contact with a digital device for mediating medical knowledge, combining pedagogy, game dynamics and online socialisation, enables users to achieve the emancipation sought by the tool's creators. The first part of the thesis sheds light on the emancipation levers present in the platform studied. In the second part, we expand on these initial observations by focusing our analysis on the hindrance that the institutional dynamics of the platform under study seem to cause to the development of playful engagement and socialisation within the community. Finally, we conclude by opening up perspectives for further research into the place of digital TPE platforms in the healthcare system, questions that have emerged from our particular fieldwork
Bouchet, Garnier Marie-Claude. "Sport et psychiatrie : à propos du sport en tant que thérapie à médiation corporelle dans le traitement de la schizophrénie". Saint-Etienne, 1990. http://www.theses.fr/1990STET6003.
Texto completo da fonteMairesse, Jean-Louis. "L' expertise médicale dans le cadre des modes alternatifs de règlement des conflits". Aix-Marseille 3, 2010. http://www.theses.fr/2010AIX32025.
Texto completo da fonteThe study of medical expertise in the context of Alternative Modes of Dispute Resolution (AMDR) leads to several conclusions concerning the notion of alternative modes of conflicts in the context of the CRCI (Regional Commission for Conciliation and Compensations), insurance companies, social security, government-validated medicine and military pensions, all of which are the focus of our study. We analyse fundamental AMDR criteria in each case study, for determining if medical expertises contribute to qualifying the latter as an AMDR. The envisaged criteria concern the place of the rule of law in these expertises the studied alternative mode procedures. If the law is excluded from discussions, does the mediator fall back on social norms or does he or she try to solve the conflict following common sense or his or her personal definitions of justice and equity? What is the place of procedures in alternative modes? Indeed, parties agree on finding a negotiated solution. Is there not a conflict when the opposition of interests is total and can only be ruled by a third party, using a jurisdictional decision? What is the outcome of alternative modes? How are agreements between parties formalized? What is the nature of the authorized agreement? Is the nature of the act contractual, jurisdictional or hybrid? It is by answering to such questions that we may conclude that the study of the medical expertise for several AMDR is close to judicial expertise when considering insurance procedures, social security and CRCI AMDR, and distinct from judicial expertise when considering validated medicine and military pension AMDR
Canet, Géraldine. "L’émotion esthétique aux frontières du lien : accordages, perceptions et représentations des limites dans le groupe art-thérapeutique à médiation plastique, en psychiatrie". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB012/document.
Texto completo da fonteOur thesis aims to define the influence of aesthetic emotion in the process of visual art therapy, on subjects suffering from psychotic disorders or boundary issues. We shall observe the way it relates to psycho-corporal boundaries, in a context where leadership of a group is assumed in hospital institution. Our study thereby details a peculiarity specific to the situation of the artist in art-therapeutic relationship, which involves his or her aesthetic sensibility, creating a mirror-effect with the aesthetic questions of the subject expressing their creativity. Our overall hypothesis is that of a link between aesthetic emotion and the bonding process (Stern, 1989) between the art-therapist and the subjects within the art-therapy group, and that this triggers perceptions and representations of boundaries among these subjects. The research took place in two stages, on four groups of adolescent subjects and two groups of adult subjects. The first phase enabled the collection of results produced prior to our initial research which focused on three groups, and during which we held art-therapy sessions in the presence of an observer and a carer. Data was collected for two goals : to understand the role of aesthetic emotion in transferential movements within the group and the therapeutic effects of these processes, in relation to the creative processes and on the formal representations in the artistic work (observation sheets, self-administered questionnaires, clinical notes) ; and to enrich the objectification of the therapeutic effect of this approach, with tests before/after (projective tests for the six groups, and, for one of them, aesthetic perception tests with eye-tracking, the first results of which are presented under development). An element of mirroring became apparent between the art-therapist (a strangeness in the aesthetic emotion) and the subjects (well-being in the aesthetic emotion, often in relation to gestures), as well as a potential connection between this mirroring and the appearance of boundaries within artistic works, at pivotal moments during sessions. We have paid special attention to this aspect in our thesis, by considering drive aspect in accordance with our examination of aesthetic emotion, at the meeting point between the scopic drive, the aesthetic gaze and its mirror effect
Falquet, Clin Christine. "Du son… Des sens : évaluation clinique des processus de symbolisation dans un groupe thérapeutique à médiation sonore et musicale en psychiatrie adulte". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB066/document.
Texto completo da fonteA qualitative research from the study of a group case retraces clinical work as it « is being done » in a plan of analytic group music therapy, on the « ordinary » ground of a day-hospital that treats adult subjects suffering from invalidating psychiatric troubles. Several voices, be they psychoanalytical, musicological, or philosophical, offer a conceptual framework with which to interrogate the encounter and the play with sounds within the group, and the way in which this play contributes to the restoration of the primary symbolisation processes that are particularly impaired for the subjects we treat. In the framework that opens a potential for multidirectional transfers and for associativity in a plurality of language, the elements gathered while observing the group’s clinical thought processes are the basis of a model of evaluation, in the sense of value extraction and of symbolisation play. From the materiality of music and sound, which calls to senso-affectivo-motricity, to the potential senses of wording, a moving process of shaping and staging develops within the group and the subjects that form the group. This process opens up on the building of the psychic reflexivity that lies at the heart of symbolisation processes and of processes through which the subjects seize experience, the latter having hitherto remained unthinkable, unfigurable and unrepresentable
Le, Bot Marie-Claude. "Le seuil clinique de l'humain". Rennes 2, 1987. http://www.theses.fr/1987REN20026.
Texto completo da fonteThis work, written under the direction of Professor J. Gagnepain, comes within the theory of mediation, which has the explaining of the human depend on the twofold demand of a research process which is both scientific and epistemological. This work essentially aims at defining the landmarks of a methodology suitable for specifying the culture event. The need for some verifying process of the different hypothesis explains the use of the pathological which constitutes an ideal "culture laboratory" as it reveals the principles of inward formalization. Aphasic errors helped me to point to the sign as the formalization of a twofold structural negativity, and the pathologies of perception led me to abandon its traditional definition based on dichotomy. Because they enabled me to ascertain that sensory perception lies at the core of the analytical approach, and triggers its fitting into situation, agnosical malfunctioning led me to adopt a dialectical definition of the sign which includes perception, analysis and input. Therefore I postulate that language is imbedded in a nature which becomes the required minimum for verbalization. Working on the idea of a first step towards the human, I analyse why and how the problematic resting within the relationships between the natural and the cultural can be encompassed neither by the idea of a complexification nor by that a total break, but that a hiatus has to be defined
Reynier, Gérard. "La douleur rebelle : chronique d'un informe cacophonique". Paris 7, 2012. http://www.theses.fr/2012PA070058.
Texto completo da fonteThe clinical study of intractable chronic pain reveals an opaque phenomenality through its resistance to any form of representability. Reluctant to let itself be treated, it still remains an enigma today, for the doctor required to cure it as well as for the patient, in spite of the confirmed therapeutic progress. As it has turned into a social issue within a few years, decision-makers have been trying to solve it, in vain. Its phenomenological exploration reveals a distorting movement underneath that blocks anys visibility, weakens the feeling of identity and plunges the subject into disharmony. Unrepresentable through language, the zones of pain constitute as many zones of corporeal discontinuities that cannot be represented and function as isolated islets of psychosis within the body. Drawn into the vortex of chronic pain, the subject then sinks into the nostalgia of his/her bygone health. Then how can we approach and come to grips with such unrepresentable in order to aim for the restoration of somatic harmony ? Beside the classical medical care, and considering the pain phenomenon cannot be spoken right away, a third way will be proposed here, that of an artistic mediation for therapeutic purposes, to try to draw a face for the pain that would as a second step allow to speak it. Such is the project presented here
Willo, Geoffroy. "Le "surgissement", opérateur clinique et métapsychologique du virtuel : comprendre les implications thérapeutiques du virtuel par la dialectique du hasard et du déterminisme en psychanalyse". Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05H132.
Texto completo da fonteOriginating from the psychoanalytic corpus, our thesis aims at raising "emergence" to the position of a heuristic enough concept able to explain on one hand, the phenomenon of "Internet and computer addiction" and on the other hand, legitimate the opportunity to integrate virtual world in a psychotherapeutic process. Through "emergence", our thesis focuses on the relationship between mankind and the unexpected contingency that we believe to be a main feature of digital phenomenology, ruled by algorithms which cannot be predicted by human beings. We are therefore offering a way, built on the dialectic of chance versus determinism as formulated by Freud, to comprehend virtuality. Thanks to a new clinical method, this research will establish that virtual world can prove to be a great mean of investigating the unconscious by exploiting brief occurences of "emergence" with the benefit of hindsight. This method is based on the following principle: the more a subject is confronted to a repressed desire, the more he or she will sustain a animist connection with the phenomenon of emergence
Golliot, Julie. "Vers une rupture cognitive et conceptuelle dans l'orientation de la dimension soignante en rééducation fonctionnelle cognitive ˸ : introduction d'un Serious Game thérapeutique agissant en tant que dispositif de médiation". Electronic Thesis or Diss., Toulon, 2020. http://www.theses.fr/2020TOUL4001.
Texto completo da fonteThis CIFRE thesis within a health organization led us to focus on executive functions, involved in cognitive control in situations requiring an articulation of actions or thoughts directed towards a final goal. These processes enable to focus on a task (Attention), to memorize and manipulate information (Working memory), to adapt to new environments or rules (Mental flexibility, Inhibition) and more generally take part when habits and automatisms are not sufficient to achieve these goals (Planning, Strategy). As patients do not recognize their disorders (Anosognosia), their therapists find it difficult to involve them in their rehabilitation so that they regain a sufficient autonomy to return home. Through our participative Research-Intervention approach, we have set up a plural methodological framework anchored in the health organization. Inspired by Design Thinking, User Centered Design and Universal Design, we conducted multiple observations, interviews, creativity sessions and user tests with therapists and patients in an iterative manner throughout our research. This allowed us to consider their representations, linked to the dynamics of the lived situation, constructed in the course of action and dependent on the actors' strategies. Thanks’ to that, we dynamically co-designed S'TIM, an immersive therapeutic Serious Game based on the theories of mind, self-determination, commitment, and activity. A great deal of attention has also been paid to the Experience lived through the proposed scenario as well as to the possibilities of learning in a virtual universe before facilitating a transfer of what has been learned into everyday life situations. By their accompaniment, therapists play a primordial role here.S'TIM thus contains keys for action, ways of mobilizing these keys, and strategies for using them in a relevant way. It therefore includes and articulates a know-how, a knowledge-understanding and a knowledge-combining that positions it as a masterpiece of expertise. This approach can also be applied in other, multiple contexts, where commitment through a SG is the keystone of the project in any situation related to hybrid forms of learning.Finally, we studied the involvement of the learning organization in the project and its appropriation of the system. While it was stakeholder, changes induced at a micro level by digital technology have not really been translated into the organizational dynamics. We find again the question of perpetuation, of consolidation allowing a real rearrangement. Support is thus essential to observe a real shift in the relationship between patients and therapists, the starting point for the emergence of new therapeutic and then organizational forms that are generally more structuring
Carayon, Pierre. "Etude de l'interaction de la chaîne A de ricine avec la membrane cellulaire : influence de sa présentation par des anticorps monoclonaux sur son activité cytotoxique". Montpellier 1, 1992. http://www.theses.fr/1992MON13522.
Texto completo da fontePodlipski, Marc-Antoine. "Le repas familial thérapeutique auprès des familles et des adolescents présentant un épisode d'anorexie mentale : approches clinique et qualitative Le repas familial thérapeutique : un outil de soin pour les adolescentes anorexiques hospitalisées et leurs familles The experience of psychiatric care of adolescents with anxiety-based school refusal and of their parents : a qualitative study Metasynthesis of the views about treatment of anorexia nervosa in adolescents : perspectives of adolescents, parents, and professionals Manger à l'hôpital et en famille avec les adolescents anorexiques : une lecture anthropologique de repas familial thérapeutique Le repas familial thérapeutique auprès des adolescentes souffrant d'anorexie mentale : quels apports cliniques lors de l'hospitalisation ?" Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR102.
Texto completo da fonteThe family meal is a relatively unknown object of study being developed in different scientific fields such as public health, sociology, or anthropology. Regarding eating disorders, the frequency of the number of meals shared with the family is inversely proportional to the emergence of such disorders as well as other psychiatric disorders in adolescence such as violent behavioral disorders, depression and suicidal thoughts. Notwithstanding its frequency, the meal is an essential moment for the development of an individual – also psychologically. Within the family life, it is a daily time of sharing and meeting which brings together the children and those who are close to them. The meal is a moment of privileged exchange, rich in behaviors and interactions: it certainly mirrors the relationship between a family and food, but it accounts even more for the bonds between the family members. The table scene constantly proposes a narrative animating and featuring those who partake of the meal. In this context, several authors have introduced a family meal as part of children’s psychiatric care. Our thesis work will be divided into three main parts. A first theoretical part will report on the role of family meals in the context of psychiatric care for adolescents. A second part will describe the program called "therapeutic family meal" as it is set up in our ward: we will explain how the therapeutic family meal is used by our medical team specialized in the care of teenagers suffering from anorexia nervosa. A third part will develop on a research conducted among caregivers participating in this program. Concerning the involved caregivers, their experience –both individual and collective– has been the subject of our research work. According to a qualitative methodology resulting from the grounded theory and from interviews made with a reasoned sample of participants in this program, we will develop, as results, the different themes characterizing this experience. Our analysis will articulate these themes through several concepts resulting from the symbolic interactions that we will have defined beforehand. Finally, we will address the cultural and methodological limits of our approach. At the end of this last part, we will discuss the concept of paradoxical proximity that emerges from the caring practice in this particular context. We will also discuss the transition at the end of this hospitalization and the setting of a family therapeutic meal involving families and caregivers. This transmission is part of the passage rite embodied by hospitalization for the sick teenager and her family. The issues concerned by the therapeutic family meal, necessary to better frame it, are the ritual approach, a socio-anthropological reflection, the question about the status of the sick teenager (at the hospital and at home), the transition between the hospital and home, and the nature of the caregiver-receiver relationship. Based on two clinical cases, and on our interviews with caregivers, we will discuss the psychopathological contributions of this practice and the new care standpoints that it implies
Dutertre, Charles-Antoine. "De l'importance de la caractérisation des différentes isoformes de RFC gamma des cellules NK pour l'optimisation fonctionnelle des anticorps monoclonaux à usage thérapeutique". Paris 7, 2008. http://www.theses.fr/2008PA077132.
Texto completo da fonteImportant efforts have been devoted to the optimization of cytotoxic therapeutic monoclonal antibodies (mAb), in particular to the improvement of their capacity to engage the activating RFcγIIIA (CD16) expressed on NK cells that are capable of antibody-dependent cellular cytotoxicity (ADCC). In the present work, we examined the expression of FcγRIl by human NK cells, as well as their role in the control of ADCC, which made it possible to define a novel NK cell subpopulation, CD56dim/CD3ˉ/NKp46⁺/RFcγlllAbright/RFcγllbright that strongly expresses inhibitory FcyRIlB. We showed that FcYRMBbright NK cells, detected in all the donors tested, exhibit an expression profile of NK cell receptors (NKR) different from that of NK RFcγll'°/ˉ cells (that predominantly express the activating FcγRIIC), as well as a reduced degranulation following FcγR-dependent activation. The second part of our work allowed the demonstration that an anti-CD20 EMAB-6 antibody developed by the Laboratoire français du Fractionnement et des Biotechnologies, presents a much higher cytotoxic activity against B cell chronic lymphocytic leukemia (B-CLL) cells in vitro than rituximab, a marketed anti-CD20 therapeutic mAb. This increased activity was linked to a much higher binding capacity to FcyRIIIA as compared to its non-optimized counterpart or to rituximab. Our studies also confirmed that the low fucose level of the EMAB-6 mAb is essential to its increased FcγRIIIA binding and efficacy. Finally, the better cytotoxic activity of this antibody as compared to rituximab was found even increased when the density of CD20 on target cells was lower
Glenat, Jean-Marc. "Des hétérotopies incluantes : exploration des usages du tango argentin dans le champ du handicap". Thesis, Paris 10, 2019. http://www.theses.fr/2019PA100151.
Texto completo da fonteThe aim of this thesis is to explore places where the world of disability meets that of Argentine tango. In these spaces, which belong to specialized institutions or associative initiatives, people with disabilities, through the practice of Argentine tango, experience a unique relationship with their own body, the body of the other and modes of social skills different from the ordinary world. These activities also allow people without disabilities" to face others by the way of particular body and sensory modalities. By questioning these uses of the body through dance where aesthetics, forms and modes of sociability are the markers of a strong identity, this work questions the contemporary corporeality as well as the issues of assignment or inclusion which go through mediation practices. Based on a concept developed by Michel Foucault (Foucault, 2009), I qualify these spaces as inclusive heterotopia. The analysis and interpretation of the process of production of these heterotopic spaces, which take the form of workshops, balls or events are thus put into perspective of the discourses of inclusion that cross our societies. This exploration uses an inductive approach that required the collection of data from different sources: interviews, images, participant observation. The field study took place in diversified territories, in France, Austria and Uruguay, over a period of 4 years. Based on a comprehensive sociological approach, it is theoretically supported by multidimensional approaches (sociology of the body and the contemporary individual, sociology of disability, genealogy and aesthetics of Argentine tango, bodily mediations)
Calestrémé, Marie. "Habiter son toit pour s'habiter soi, de l'espace psychique à l'espace vécu : contribution au développement identitaire de l'adolescent en institut médico-éducatif par la mise en oeuvre d'un dispositif à médiation thérapeutique". Thesis, Toulouse 2, 2017. http://www.theses.fr/2017TOU20099.
Texto completo da fonteIntroduction: Adolescence is the age of transformations and changes in balance between the inside and the outside. The program "My Roof and I!" aims at exploring the theme of “the home environment”, as a marker of identity, through the setting up of a program of therapeutic mediation, based on the assumption of the existence of a link between the appropriation of one’s living space and the construction of identity. Method - 65 teenagers with a mental disability took part in the study, being taken care of in a Medical Special Needs Educational Institute presenting a mental disability (average age: 16.58; S.D.: +/-1.55) with an experimental group (n=32) who followed a therapeutic mediation program consisting of 6 sessions and a control group (n=33). The following investigation tools were used: the Toulousian Self-Esteem Scale (E.T.E.S), the Big Five Questionnaire for Children (B.F.Q.-C) and the Multidimensional Anxiety Scale for Children (M.A.S.C), following a test-retest protocol. This quantitative approach is completed by a qualitative approach, focused on sociodemographic, diagnostic aspects and the therapeutic process in workshops. Results – The study includes 3 parts: 1. Singular typology of teenagers in a Medical Special Needs Educational Institute; 2. Development and assessment of an art therapy program from a comparative perspective. Among the main results, two therapeutic working axes can be seen: the somato-emotional axis and the psycho-social axis; 3.Clinical assessment of the workshop process and creative work made by the teenagers. Conclusion - The program of art therapy enables a whole set of dimensions of teenage identity to be improved. The teenagers who benefited from the program gradually appropriate spaces which help them fix their identity. This approach should be developed within the institutions caring for teenagers presenting a mental disability
Bédard-Goulet, Sara. "Lecture et réparation psychique : le potentiel thérapeutique du dispositif littéraire". Thèse, Toulouse 2, 2012. http://hdl.handle.net/1866/9067.
Texto completo da fonteThis research is interested in the therapeutic potential of literary reading and looks for a better understanding of the literary device, particularly in its interaction with the reader. Basing our work on fictional worlds theory, we make the hypothesis that literary work induces a simulation of the reader’s psychic life. Using the semiotic channel of the text and according to representation devices, the reader seizes the words’ sense and adapts the story for himself. As an aesthetic experience, literary reading calls for the reader’s past experiences and engages his emotions in a different way than any other type of discourse. The gesture of reading already implies a certain subjectivity for the reader and we can therefore, as we take a closer interest to text-reader interaction, imagine a therapeutic use of literature. Proposing literary work as a support for psychic development, we have designed, ran and evaluated therapeutic reading and writing sessions in three mental health infrastructures, in Toulouse and Montreal. Destined to a psychotic audience, these reading sessions are based on art therapy principles and concretize the (re)constructive aspect of literary reading within our theoritical reflection. On one hand, our observations challenge the literary studies perspective, the function of the literary work and the activity of the reader and, on the other hand, they lead on therapeutic propositions for reading and writing sessions in a psychiatric context.
Réalisé en cotutelle internationale avec l'Université de Toulouse II-Le Mirail
Busquet, Magali. "Synthèse et évaluation biologique de conjugués dolastine 15-oestradiol pour le ciblage de cellules cancéreuses". Montpellier 2, 1998. http://www.theses.fr/1998MON20018.
Texto completo da fonteBraun, Sandra. "Arts du Cirque et remaniements psychiques : la piste comme Surmoi d'emprunt, ou le cirque comme pré-texte". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC190.
Texto completo da fonteIn the fields of artistic mediation, psychoanalysis has very rarely focused on the circus as a therapeutic medium. The hereby approach attempts to articulate this connection. The proposed thesis shows that the practice of circus arts can be a conveyor of psychological reorganizations, within a sensitive transferential framework.From the perspective of the distinctive features of circus arts, I bring forward psychological specificities that play a role in this therapeutic space.The circus appears as a subversive heterotopic space (Foucault), where balances are rendered unstable. This imbalance, which is inherent to circus arts, could also be a concern for psychological authorities. The circus ring could be considered as a borrowed superego. A clement superego, similar to the one described by Freud in Humour (1927), allowing to experience the world as a child's play. A superego that reconciles with the self, allowing movement in the sensory space. Etymologically, the ring is the place of trace, a marked surface, that aliows the notion of footprint, by approaching the sensory dimension as the initial matrix, through the experienced body. Thus, it generates the update of several native echoes that I describe from the perspective of feeling, sight and composure.The circus is also a real space, reanimated by the experience of animal nature. In this respect, it allows a space of silence, necessary to the articulation of language. It is an unavoidable pretext and pre-verb that resonates a somewhat worrying familiarity. The circus ring thus appears, where the unpredictable can emerge, and where an exit from the stasis is possible, so that a subjective dynamism takes shape
Sanahuja, Maria de la Almudena. "Maigrir sans mourir à l'adolescence : réaménagement de l'enveloppe psychique de l'adolescente pendant sa perte de poids ; par le biais d'un médiateur corporel esthétique". Besançon, 2009. http://www.theses.fr/2009BESA1032.
Texto completo da fonteThis present thesis belongs to the field of the psychosomatic research. This study proposes a new approach in the treatment of the obesity for teen girls. Through a workgroup in aesthetic physical mediation (named "Look"), the psychic envelope is reorganized by working on the representation of the body, in mutation under the adolescence. The originality of our proposition of intervention on obese body becoming slimmer is the "talking action". More precisely, by using the front door of the symptom related to the corporeal of the subject, we create a shortcut, below the parole, with an approach of the physical envelope external of the image of Self. Therefore, we try to have an effect on the intra-psychic level of the subject to allow him the installation of clearer limits bound to his fantastical images, what will have as a result an intensification of the structure of Ego. By this fact, we strengthen the Ego of the subject by a new demarcation of the Ego Skin. This new unconscious image of Self restores a narcissistic stability to the subject in its body. While leading a transverse study we measured the impact of this workgroup on the processes of the cure and their stability. By means of two projective tests (Rorschach and Test de l’arbre) we compared two groups, one clinical and one test. Only the clinical group has benefited of this workgroup. Our results reveal a better restoration of the psychic envelope and a redefining of the clearer image of the body in the experimental group. This opens new perspectives of understanding and care for this outstanding population. Besides, this work allows a new lighting on the processes of change of the psychic envelope and deformation of the image of the body to the obese subjects so offering a new approach and an understanding of the phenomenon of loss of weight for this population
Dumoulin, Quentin. "Les dispositifs numériques en psychopathologie : nouvelles réalités du sujet et (auto-)traitements dans la structure des psychoses". Thesis, Rennes 2, 2020. http://www.theses.fr/2020REN20018.
Texto completo da fonteThe impact of digital devices in psychopathology is a current issue that is fuelling many debates in the scientific literature and clinical practice. New symptoms are attributed to these technological objects questioning their effects on both social bond and subjectivities. After setting the different ways the literature review presents these issues, we show that the analytical paradigm has regularly drawn inspiration from mechanical and mechanistic theoretical models. The Lacanian subject then appears as a frontier concept, just as the Freudian unconscious, which allows us to extract ourselves from the strict human/machine binarism. We show that clinical study of psychoses' structure has, since the beginnings of psychoanalysis, taught practitioners about the (auto-)therapeutic constructions that subjects could carry out by drawing on the machine. We then question the way in which the analytical paradigm can recognize these devices as possible "digital crutches" for the clinical study of psychotic supplementary devices. On the strength of the therapeutic results obtained during digital workshops, we show that it is first and formost the position occupied by the clinician in the transference which can allows us to find therapeutic levers in these objects. This is less a digital clinical practice than a clinical use of digital media. Finally, we question the extent of to which these devices can facilitate or hinder the implementation of these "transferential partnerships". Therefore we propose some clinical and therapeutic orientations in the use of digital objects with psychotic subjects
Gabus, Joëlle. "Modérateurs de l'efficacité d'une approche de médiation auprès de jeunes suivis pour troubles de comportement en vertu de la Loi sur la protection de la jeunesse". Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27102.
Texto completo da fonteTomaszewski, Crystal. "Danse-thérapie dans la prise en charge psychothérapeutique de femmes victimes de violences sexuelles, issues d'un parcours migratoire : étude comparative longitudinale et évaluation thérapeutique". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCC012.
Texto completo da fonteNowadays, there is an international interest in challenging the psychological and sexual violence experienced by women. Victims of violence, and particularly women, are more likely to suffer from physical and mental health issues. They also face more sexual violences alongside its highly traumatic impact. When systemic and clinical factors do not let these women access the usual mental health care support, the development of innovative therapeutic approaches can be an efficient alternative. LOBA association has developed the “RECRÉATION program”, a dance as therapy workshop.This present research in clinical psychology evaluates the therapeutic effects of the RECRÉATION program. This research focuses on the processes related to trauma, sexual violence, individual attachment strategies, empowerment, somatically expressed disorders and its associated symptoms. Finally, a specific interest is also devoted to the connection between the mind and the body.Method: Three methods of research are associated. Quantitative data (n=2 groups, N=26) were collected through scientifically validated self-questionnaires (PTSD symptoms, anxiety, depression, body image, quality of life, social support, social relationships, symptoms of psychiatric pathologies, mentalization and attachment). Clinical interviews were conducted with N=3 women not receiving the RECREATION program. We also carried out clinical observations with four groups benefiting from the RECRÉATION program (n=4; N=40). Semi-structured interviews were conducted with professionals (N=19) and the RECRÉATION participants (N=15). Data saturation was obtained.Results: The RECRÉATION dance therapy workshops contribute to reducing anxiety symptoms, general emotional distress, and general symptoms of post-traumatic stress disorder (PTSD), particularly neurovegetative hyperactivity. They also improve overall self-perception, influence the perception of physical health, and initiate improvements in trust and understanding of others.Longitudinal qualitative data highlighted individual factors that either facilitated or hindered the therapeutic process, such as mentalization capacities, attachment strategies, and identity construction. A psychodynamic and psychoanalytic approach is essential for identifying the negative aspects of trauma and maintaining the therapeutic alliance. Thematic analysis revealed a high level of acceptance and appreciation of dance therapy (DcT) among both professionals and participants, with beneficial effects noted in relation to specific support and therapeutic goals. Aside from the reduction in PTSD symptoms, professionals effectively identified the challenges faced by participants.Discussion: Intersectional positioning and institutional psychotherapy are essential for the management of our population of interest. Furthermore, the improvement of psychological trauma is extensively explored through the lens of PTSD. A psychodynamic and psychoanalytic exploration is beneficial for the orientation and clinical management of patients. Finally, dance therapy is a therapeutic tool which can not only enrich the existing care offerings but, especially for our population of interest, serve as an entry point into psychotherapy.Clinical, Practical, and Scientific Perspectives: To further the development of dance therapy, future research should focus on variables specific to the target populations and clinical issues of interest. Continuing existing research will strengthen the case for dance therapy and provide a more precise argument for its therapeutic efficacy. Finally, it is necessary to deepen and sustain the psychodynamic and psychoanalytic approach in the treatment of PTSD, trauma, and the negative aspects of trauma
Dayoub, Sue Ellen. "L’évaluation de groupes de thérapie relationnelle de femmes âgées, atteintes de la maladie d’Alzheimer, à un stade avancé". Thesis, Lyon 2, 2011. http://www.theses.fr/2011LYO20030.
Texto completo da fonteAim - The number of patients with Alzheimer's disease increases more and more (a pathology for which there is still no treatment that can stop its progression). The aim of this study is to highlight the interest of "song mediated groupal therapy (psychodynamic inspired group therapy) on behavior disorders and depression when taking care of elderly people with Alzheimer's disease at an advanced stage.Method - We create 10 groups of 6 to 8 elderly women each that would participate to twelve overall therapy group seances at a single seance per week basis. These are named “singing groups”. We create 10 groups of 6 to 8 elderly women each the so called "control groups", that would not participate to the group therapy.We evaluate the groups (control and singing) twice; at the beginning and the end of the session. The tools that are used are the NPI (Neuro Psychiatric Inventory), the Cornell scale and the Cohen-Mansfield agitation inventory.Results - For the 61 subjects who participated to the “groups singing”, we observed a significant improvement (p <0.01) at all scales but the size effect (associated to the group therapy) is very large.Conclusion - In conclusion, we were able to demonstrate an impact on the humor and the psychobehavioral disorders, with a statistically significant impact with an acceptable number of subjects. This improvement was noticed on the three scales (NPI, CMAI, Cornell)
Kohler, Robert. "Etat des lieux de la Médiation animale dans les Etablissements d'hébergement pour personnes âgées dépendantes en France : De la théorie vers la conception d’un cahier des charges". Thesis, Lyon 3, 2011. http://www.theses.fr/2011LYO30044.
Texto completo da fonteWe are researching the implications of animal assisted therapy within a social care facility in an attempt to respond to the legal and managerial controversies surrounding the scheme. Our research is part of a societal trend towards recognizing the citizen rights of dependent elderly people, and in particular their social and cultural rights. We are studying important questions relating to the power of ageing people to make their own decisions about their lives. That is our main aim in researching the use of companion animals, which may be a revealing tool when used in an institutional setting.We will begin our work by discussing the practical and theoretical implications of the plan to introduce a trained dog into a nursing home for dependent elderly people. We will first discuss the issues related to the knowledge and understanding of the users which will be highlighted through animal assisted therapy (1st part). Secondly, we will develop the managerial implications related to the implementation of this idea in an institutional framework and the possibility of introducing a new space for reflection and the construction of meaning (2rd part). These elements will be used to develop specifications for the animal assisted therapy project
Bellusso, Perrine. "Intérêts de la psychothérapie à médiation sensorielle dans le cadre de la prise en charge des troubles de la relation et de la communication chez des enfants autistes sévèrement déficitaires". Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAG028.
Texto completo da fonteThe first objective was to offer a definite analysis of the theoretical models relating to the etiology of the autistic syndrom, with a very particular focus on the place of sensory features in the autistic pathology. On the basis of this theoretical study, we’ve made the hypothesis that a link could exist between sensory disorders and relation and communication disabilities in the autistic syndrome.Thus, we’ve conceptualized an approach of psychotherapy with sensory mediation, intended for the taking care of relation and communication disturbances from autistic children showing intellectual disabilities. We’ve developed the framework of this approach by combining the theoretical and practical foundations of several sensory mediated therapies. We’ve evaluated the interest of psychotherapy with sensory mediation, within the framework of an applied research program with the Medico-Educational Institute named “Le Rosier Blanc” (Saverne, 67, France). We present the devices of psychotherapy with sensory mediation, as well as the results (qualitative and quantitative)
Bracq-Leca, Herminie. ""L'acte-sentir" dans les médiations sensorielles olfactives en milieu carcéral : de la sensation perdue à la sensation retrouvée". Thesis, Lyon 2, 2014. http://www.theses.fr/2014LYO20089.
Texto completo da fonteThis thesis questions an innovative group setting, using an olfactive medium. It was started to meet and to listen to criminal patients in a psychiatric ward in prison. This new practice relys on the need to invent a way to react to the extreme seriousness of the mental illnesses in this ward. The choice of smell, as mean to get in touch, opens a wide field of reflections at the cross roads of philosophy, developmental psychology, neurosciences and psychoanalytical theory. “L’acte-sentir” the sensing-act is a proposal to pattern the different processes linked to smell as a medium. This work fits in groups or individual set-ups. Primary forms of symbolization appear with this medium, and illustrate a lost subjectivity. Listening to these words and helping associative work, is therapeutic with these suffering patients, who cannot speak easily. This work request a full body and mind implication. Use of the sens of smell to attempt to make sens to nonsense
Masson, d'Autume Adèle de. "Lymphocytes B régulateurs dans la GVH chronique humaine et rôle de la myosine 18A dans la cytotoxicité des lymphocytes NK". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC177/document.
Texto completo da fonteAllogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for many patients with haematological malignancies. In almost half of the cases, it is complicated by chronic graft-versus-host disease (cGVHD). Regulatory B cells are a population of B cells secreting interleukin (IL)-10 that can inhibit the immune responses. We have shown that in patients with active cGVHD, the frequency of regulatory B cells is decreased in the peripheral blood. Regulatory B cells are enriched in the memory B cell and plasmablast B cell pools. Increased plasmablasts frequencies and decreased memory B cells frequencies were found in patients with active cGVHD, suggesting alterations in the terminal differentiation of B cells. Our work also focused on NK cells that have a cytotoxic role. We identified one surface receptor of NK cells, CD245, as myosin 18A. Myosin 18A is involved in the organization of the cytoskeleton and is a receptor of the surfactant A. We have shown that myosin 18A was a coactivating receptor of the NK cytotoxicity and that this increase in cytotoxicity could be linked to the stimulation of the expression of CD137 (4-1BB) on the surface of the NK lymphocyte. These results suggest a potential therapeutic role of the use of specific CD245 agonist antibodies
Finkelstein, Claudia. "Liaisons thérapeutiques chez patients psychosomatiques et des patients atteints de crises de panique en groupes Photolangage®". Thesis, Lyon 2, 2013. http://www.theses.fr/2013LYO20051/document.
Texto completo da fontePsychosomatic patients and those suffering from panic disorder have a history of medical treatments for their body ailments and they have also an intense psychological distress. This research is divided in three phases:Phase 1A retrospectiveA control group was selected from 417 asthmatic patients of the Hospital de Clinicas J. de San Martin (Buenos Aires, Argentine). It was established an association between asthma degree and type of compliance (X 2 = 53.42 significant at 1%). It was found that in all kinds of asthma, lower probability of improvement corresponds to patients who discontinued ≥ 3 days and/or or changed the dose of medication. Patients with good compliance have 87% of chance to improve and those with poor compliance only 38%.Prospective Phase 1B asthmatic word groups33 patients were evaluated with severe and almost fatal asthma for 1 year in a program that included word group. At the beginning of the therapeutic word group all patients had a bad compliance. At the end of the year, the proportion of patients who did not fulfil their treatment correctly was 10%. Nocturnal asthma is associated with compliance variables and is statistically significant (p <0.001).The direct association between improvement in spirometer and compliance variables is significant (p <0.001).Phase II prospective asthmatics patients in Photolanguage® groups.Psychological approach in Photolanguage® groups for asthma treatment is a variable able to influence favourably the evolution and prognosis of these patients as it improves compliance and favours free association, expanding preconscious and symbolization.Also they could turn a more complex psychic apparatus, and showed no emergencies or hospitalizations. The psychosomatic patient's psychic suffering began in archaic time and his mother´s continence was abruptly changing. Patients could built a more autonomous identity after many ambivalence battles.Phase III prospective. Patients with panic attack in Photolanguage® groups.The psychological approach to patients with panic disorder in Photolanguage® groups is a useful tool for the evolution and better prognosis, in addition to the necessary pharmacological indications. These patients have a history of punishment, humiliation and psychic pain, which occurred when their psychic apparatus had some level of symbolization. They showed no subsequent panic attacks without medication, unbearable anguish decreased. They could differentiate characteristics about deadly situations from those that are not and also between time before and now. A Photolanguage® group creates the necessary distance needed to create links favouring preconscious thinking ability and transcription processes. Psychic work isdone simultaneously over the group level and over their effects on the individual level.Number of preconscious representations increased, patients could build autonomy and certain otherness levels, with vital and possible identifications. Photolanguage ®produces personal work awareness (foundation sense) allowing each think and connect with their own history
Orrado, Isabelle. "La résonance comme concept psychanalytique. : Les médiations thérapeutiques : une mise en résonance de la jouissance pour un traitement par l'art". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR2031/document.
Texto completo da fonteThis thesis seeks to identify what makes Man a person of substance whose body is sensitive. If the ego vibrates and the subject beats, the “parlêtre” resonates via the drives. We use resonance as an operative concept in order to stake how jouissance is acting the parlêtre: resonance of the body and of the language, through the “a object”. Our choice of study focuses on language disorders, not as speech dysfunction, but as agitations. Lalomania, coprolalia, echo of thought or echolalia show the direct impact of language on the body and its treatment. We are reaching hereby the language materiality: if the saying is the real weight of the subject, the “reson” is the real of the language. In this logic, schizophrenia becomes resonant madness, paranoia a reasoning madness, while autism encloses the subject in a petrified resonance. The neurotic is condemned to live again and again the Other melody. We are proposing a fundamental revisit of the practices of therapeutic mediations through art within the child clinic. The mediating object is situated at the junction between the patient’s interest and the psychologist’s desire to work with this object. He will then adopt what we call a “thoughtful position”, a particular mode of presence where he turns himself into a partner of the child. The clinician then becomes a creator of “vacuum-in form”, which serves as a resonance board (sounding board) for jouissance. As in art, the real of the “réson” is invoked to allow it to find a new destiny. By letting be, the mediation workshops are places where art becomes a possible treatment by resonating jouissance
Olivier, Stéphane. "Développement de la plateforme cellulaire EB66 dérivée de cellules souches embryonnaires de canard pour la production industrielle d’anticorps thérapeutiques à activité ADCC améliorée". Nantes, 2010. http://www.theses.fr/2010NANT33VS.
Texto completo da fonteMonoclonal antibodies (mAbs) represent the fastest growing class of pharmaceuticals. However, prohibitive therapeutic costs call to develop cheaper and more active molecules. To this end, one of the promising strategies is to enhance mAbs efficacy through an improved antibody dependent cell cytotoxicity (ADCC) correlated with mAbs fucosylation level. EB66 cell line, a duck embryonic stem cell-derived substrate, displays unique regulatory and industrial features: they are genetically stable, immortal, and reach high cell densities in serum-free medium. The fact that avian species have been described to naturally produce low-fucosylated antibodies prompted the investigation on the use of the duck EB66 cells for the production of mAbs with reduced fucose content and enhanced ADCC activity. The aim of this work was to establish and optimize technologies dedicated to the development of the EB66 cellular platform for the production of therapeutic mAbs. A selection procedure has been developed to isolate producer clones. A yield titer higher to 1 g/l has been reached thanks to the optimization of a specific expression vector associated to the development of the production process. The mAbs produced on EB66 cells display a glycosylation profile comparable with mAbs produced on the Chinese hamster ovary cells, with a naturally reduced fucose content resulting in a strongly enhanced ADCC activity. Furthermore, we observed a correlation between mAbs fucosylation and expression level of the alpha 1,6-fucosyltransferase within producer clones. The EB66 cells have therefore the potential to evolve as a novel cellular platform for the production of high potency therapeutic antibodies
Di, Bisceglie Frédéric. "Les médiations thérapeutiques comme dispositif de prise en charge pour les enfants avec un trouble du spectre de l’autisme : Une approche neuropsychologique et psychanalytique". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR2037/document.
Texto completo da fonteIn France, several controversies about the psychoanalytical cares of autism have resulted in a proposed law dated October 2016 forbidding all kind of psychoanalytical practices and obliging therapists to apply the ABA method as the preferential way of taking care of autism spectrum disorders. The aim of these thesis is to help align these divisions through the modelling of the therapeutic mediations based on a neuroscientific and psychoanalytical approach. We hypothesized that the symbolization processes (semantical and metaphorical recategorizations) supported by the transference relationship improve autism spectrum disorders through an increasingly complex elaboration of the Real. After having brought to light a Freudian epistemological break which causes the repression of the psychoanalysis’ neuroscientific origins, we have reinitiated dialogue with neurosciences. Thus we have introduced the autism spectrum disorder as a neurodevelopmental locked-in syndrome caused by an unique adaptation of the neural network of the Ego (dynamic core) under crippling conditions caused by this neurodevelopmental disorder. The therapeutic mediations enable us to highlight the fact that the symbolization process in creative process depended on the simultaneous activation of neural network used by language and art, facilitating the synaptic strengthening between the representations of the two areas, what allows the patient to communicate his painful experience through an artistic/metaphorical language. The repeated expression of his experiences would allow reorganizing of the dynamic core of the Ego into a non-pathological way. Finally, five therapeutic mediations allow us to argue that it is possible to integrate the subjectivity into structured and theoretically motivated interventions, proposing a real means of evaluating their efficiency without affecting the quality of the care
Qiu, Shihong. "Synthèse et caractérisations de nanoparticules d’or pour la vectorisation de principes actifs anticancéreux". Thesis, Limoges, 2016. http://www.theses.fr/2016LIMO0021/document.
Texto completo da fonteToday, in the anti-cancerous treatment, the increase of the cytotoxic activity of natural active compounds and the decrease of side-effects during the treatment remain one of the greatest medical problems. In this work, two natural active compounds, which have great interest in anticancer-applications, are extracted from plants. To increase their water-solubility, a new drug delivery nanovector based on gold nanoparticles has been synthesized with several steps. The nano-drug-delivery-vector, between 30 and 200 nm, can be concentrated to the tumor tissue only, by EPR effect. The nanovector is built on a core of gold nanoparticles covered by PEI, bearing anchored cyclodextrin, in which the drug is encapsulated. Accidental killing of healthy cells by the drug is avoided by this way. The system is characterized by IR, UV-Visible, GTA, TEM, DLS and zeta potential. “in vitro” tests are realized on two prostate cancer cell-lines PC-3, DU-145 and two colon cancer lines HT29, HCT116. The results show an improvement of the activity of the natural compound by using gold nanovector. The same system is used to deliver a photosensitizer. A chlorin obtained from chlorophyll a is fixed onto the surface of spherical or triangular nanoparticles. The same characterizations are used as the former delivery nanosystem. Their photocytotoxic effet is tested on HT29 cancer line. An improvement of the activity by using nanoparticles is also observed
Danzi, Giuseppina. "Théâtre et psychanalyse : Sur le "comme si" dans la psychanalyse, le théâtre et les neurosciences comme voie d'accès à la résonance et ses facteurs thérapeutiques dans la médiation". Thesis, Nice, 2014. http://www.theses.fr/2014NICE2042/document.
Texto completo da fonteThe links between dramatic art and psychoanalitic art highlighted in this thesis allow us to find a common field of research which refers to the « as if ». This area concerns the relationship between fiction and truth, through an illusion that turns out to be paradoxically true, in that is bearer of a particular truth, the one of the subject. In particular, two aspects were examined: the heuristic value of the « as if » knowledge and its ability to allow an original encounter with the Other. Not only psychoanalysis, drama, but also the recent studies in neuroscience converge on the central dimension of this encounter with otherness that turns out to be constitutive of the subject. The intersections between these disciplines allow the author to trace the coordinates of a transdisciplinary field, precisely based on the « as - if - in - the presence ». This research field allows us to bring new elements to the theoretical model concerning the use of the « as if » dramatic device in therapeutic mediation, highlighting some therapeutic factors specific to this art that find a scientific support in neuroscience. The possibility to use the « as if in the presence » of drama as a medium would be liable to restore invoking dynamics in « a potential space and time of resonance » allowing us to go towards the encounter with the other. The game of the presence of dramatic art is finally considered in therapeutic field as a « protected crossing » from intersubjectivity to Otherness, from gesture to speech, from Imaginary to Symbolic to lightly touch the Real
Lo, Piccolo Giuseppe. "Images violentes et violence de l'imaginaire : le Photolangage comme dispositif de transformation de la violence auprès d'adolescents agresseurs sexuels". Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO20055/document.
Texto completo da fonteThis research explores the use of Photolangage© as a therapeutic tool for promoting relational processes and the development of symbolisation in group settings. Its capacity to hold and transform psychic reality is examined, particularly the possibility of dual holding of intense drives - by the group and by the mediating object – and of their transformation through the use of this kind of therapeutic method. The potential of such a therapeutic technique is explored, how it can contain, transform and perhaps even predict aggressive or violent behaviours in participants of the group. To this end, I took part in setting up and co-leading a therapy group for adolescents who engage in violent sexual acts. The case study presents an experimental and innovative small group therapy structure, with sexually aggressive minors, which was organised so that verbal sessions alternated with Photolangage© sessions. Observation and analysis of this method and this clinical practise bring to light the processes at work within this unusual framework, and highlight the role that mediation via photography can play at the heart of therapeutic support groups.This research presents the dual functions of Photolangage© as therapeutic and research methodology. The relationship between image and imagination, and between image and emotion, form the core from which questions about transformation of emotions and violence are broached. The relevance and efficiency of these specific groups and their capacity to contain and hold violence better than individual therapy structures is explored; how to better manage and transform, for improved social integration of our patients
Lecointe, Mariane. ""Des soins ...à soi" : Modélisation d'un dispositif d'accompagnement psychologique par la socio-esthétique en oncologie gynécologique et mise en évidence de ses effets psychiques thérapeutiques". Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE2032/document.
Texto completo da fonteThis study aims both to develop a model, as well as to highlight the therapeutic psychic effects, of a psychological accompaniment set up group that proposes to use the mediation of socio-aesthetic care in the treatment in charge of patients met in gynaecological oncology.Thus, we propose, in the first place, to develop the presentation of the cosmetological thread which corresponds to the progress of the research set up, as well as that of the cosmetogram which is the observation grid constructed in order to facilitate in a second time the identification of the psychic processes running in the workshops. The clinical presentation of our patient groups allows us to illustrate at the same time the path of patients in the research set up and the use of the cosmetogram.We argue that the specificities of this original set up, in the hospital care landscape as it is proposed to women with female cancer, are source of individual somato-psychic restoration aimed at a revivifying psychocorporal remobilization. Indeed, we have identified several ones (sensory multimodality, the group, the mediating objects and the binomial animator) that would allow the implementation of a psychodynamic accompaniment of re / self-investment by the mobilization of particular psychic processes for patients still under the impact of somatic and psychoaffective break-ins generated and / or reactivated by the experience of disease and of medical care.The area of psycho-socio-aesthetic experiences would particularly mobilize the psychic reflexivity process and offer an interesting support for the restoration of the psychic envelopes of patients well harmed by disease and medical care. We also explored how the process of the feminine works, focusing on the relational dimension of the set up, more specifically on its identificatory and transferential issues. Thus, from this clinic, we have been interested in the psychic processes that seem to favor a dynamic of narcissistic-identity and libidinal readjustments in our patients and lead to a recovery of the process of female subjectivation and subjectivizing appropriation of the experience of cancer
Rey, Béatrice. "Modelage et psychose : de la matière brute à sa mise en forme : sensorialité, travail de l’archaïque et symbolisation". Thesis, Lyon 2, 2010. http://www.theses.fr/2010LYO20113/document.
Texto completo da fontePractising the therapeutics mediation in group by the modeling of the earth with autistics and psychotics persons underlines the modalities/mode of constitution of the “medium malleable” and the work that it allows.The latest makes possible, through the action of modeling within framework plan, a setting of sensori motor (or sensorial traces), prior to the composition of the body image.The work of the “medium malleable” keeps the forms of the psychological envelope, as an individual plan or as a group.The constituted shapes emphasize the resort to symbolic acts that can be listed, witnesses of the state of composition of the psychological envelope. From the bi-dimension (adhesive identification)/2 dimension measurement to the 3 dimension measurement (projective identification), the subject crumbles the material, divides it, breaks, separates, gathers, puts together and builds. The work of the “medium malleable” and its mode of use update the link to the primary object. They also allow focusing on the “transfero-contre-transférentiels” effects. The specificity of the therapists (in co therapy in this case) concerns the acting of their own sensoriality, through the faculty of a “modeling interpretation”
Goulème, Nathalie. "Indicateurs posturaux et oculomoteurs impliquant l’intégration cérébelleuse dans les troubles neuro-développementaux". Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS020.
Texto completo da fontePostural control involves cerebellar integration of several sensory inputs (vestibular, visual and somesthesic). We evaluated postural control with force plateform: Techno Concept®, Multitest Framiral® and the eye movements with the Mobile e(ye)BRAIN T2® in healthy children population as well as in children with developmental disorders (autistic spectrum desorders and dyslexia). The results of our studies showed a developmental aspect of postural and oculomotor factors in healthy children and a deficit of both postural and oculomotor control in children with autistic spectrum desorders and with dyslexia. Indeed, in these children postural stability is poor and visual strategy is different with respect to healthy children. Our hypothesis is that these deficits could be due to a lack in using appropriately sensory inputs and of their integration via cerebellar activity. The importance of these studies is to better understand the involvement of cerebellar function in such developmental disorders. Our final goal is to suggest new training tecniques to use sensory inputs more efficiently in these children with developmental disorders
Sens, Dominique. "L'image critique : Une approche psychanalytique du surgissement de la forme dans la rencontre clinique en art-thérapie". Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05H103/document.
Texto completo da fonteThe goal of this research project is to define the scope of clinical practice in psychotherapy that uses artistic mediations. It also intends to examine the position of the psychotherapist in the context of care through an artistic mediation (painting, drawing, clay).The clinical situation in Art Therapy has two distinctive characteristics from verbal therapy: 1. the passage from a face to face interaction that implies a visual contact to the presence of the clinician outside the patient’s visual field once s/he is working at an easel, 2. the creation of a plastic object under the sight of a clinician.This research is based on a work of analysis of fundamental psychoanalytic concepts applied to mediated psychotherapy and on the development of the concept of “critical image.” To denote an image as critical is to consider it as a place of exerted tension and exerted crisis of a symptom according to different logics of symbolization. The meta-psychological hypothesis that guides my research relies on symbolization processes based on the inter-subjectivity of sharing different levels of symbolization between the therapist and the patient. A case study of a patient undergoing art therapy constitutes the methodology of this research
Maurer, Martine. "Souffrance dépressive récurrente et fragilité bipolaire : mouvements régressifs et défaillance du contenant psychique : étude comparative au Rorschach et au Mmpi-2". Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAG053.
Texto completo da fonteOur study demonstrates that unipolar and bipolar depressed subjects present a difficulty of excitement flows regulation, arising from the failure of the pare-excitations function, named in our research: "psychic container failure". We highlight this malfunction by the cotation of thirty Rorschach protocols, using a regression index, developed for our research. We carry out a prospective study in complementary from the notes of the scales and subscales of the Minnesota Multiphasic Personality Inventory 2 of these subjects. We identify the constants, low notes, and elevations, appearing frequently and significantly in this population, which is a constant low note to Ego Strength Scale. We use these results to point out the value of therapeutic support based on groupal mediations as way to restore the internalized psychic protective shield