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Artigos de revistas sobre o tema "Methylone"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 1 de fevereiro de 2022

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1

Poyatos, Lourdes, Esther Papaseit, Eulalia Olesti, et al. "A Comparison of Acute Pharmacological Effects of Methylone and MDMA Administration in Humans and Oral Fluid Concentrations as Biomarkers of Exposure." Biology 10, no. 8 (2021): 788. http://dx.doi.org/10.3390/biology10080788.

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Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for conventional psychostimulants, such as MDMA. To date, little is known about the human pharmacology of methylone; the only available information has been provided by surveys or published intoxication reports. In the present observational–naturalistic study, we evaluate the acute subjective and physiological effects of methylone after oral self-administration in comparison to MDMA in

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2

Sadurní, L. Martínez, M. Grifell, L. Galindo, et al. "Methylone consumption characterized through samples handled by users." European Psychiatry 33, S1 (2016): S117. http://dx.doi.org/10.1016/j.eurpsy.2016.01.129.

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IntroductionIn recent years, the increasing use tendency of NPS has motivated both awareness and concern about their identification and potential harmfulness. Synthetic cathinones represent a significant proportion of the NPS available and methylone is one of the most frequently found in Europe.ObjectivesThe aim of the present study is to determine methylone presence and characteristics from the samples analyzed by Energy Control between the years 2009 and 2015 in Spain.MethodsFrom all 21,198 samples analyzed from august 2009 to august 2015, only those in which methylone was found are studied

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3

Monteagudo, E., M. de Dios, A. Trabsa, et al. "Is methylone a new public health threat in Spain?" European Psychiatry 41, S1 (2017): s871. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1749.

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IntroductionDue to the continuous search for new, legal, less expensive, and more powerful highs by drug users, the synthesis of novel cathinone derivatives has become a fruitful industry, leading to a fast emergence of new alternative substances every year. Methylone (3,4-methylenedioxy-N-methylcathinone) is one of the substances that rapidly emerged as the main ingredient of “bath salts”, becoming readily accessible on the Internet. This fact has raised concerns about its potential harmfulness.ObjectivesThe aim of the present study is to analyze the presence of methylone in samples delivered

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4

Barrios, L., H. Grison-Hernando, D. Boels, R. Bouquie, C. Monteil-Ganiere, and R. Clement. "Death following ingestion of methylone." International Journal of Legal Medicine 130, no. 2 (2015): 381–85. http://dx.doi.org/10.1007/s00414-015-1212-4.

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5

Centazzo, Nicole, Michael R. Chojnacki, Joshua S. Elmore, et al. "Brain Concentrations of Methylone and Its Metabolites after Systemic Methylone Administration: Relationship to Pharmacodynamic Effects." Journal of Pharmacology and Experimental Therapeutics 377, no. 3 (2021): 398–406. http://dx.doi.org/10.1124/jpet.121.000531.

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6

Piao, Ying-Shan, Frank Scott Hall, Yuki Moriya, et al. "Methylone-induced hyperthermia and lethal toxicity." Behavioural Pharmacology 26, no. 4 (2015): 345–52. http://dx.doi.org/10.1097/fbp.0000000000000135.

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7

Pearson, J. M., T. L. Hargraves, L. S. Hair, et al. "Three Fatal Intoxications Due to Methylone." Journal of Analytical Toxicology 36, no. 6 (2012): 444–51. http://dx.doi.org/10.1093/jat/bks043.

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8

Kovács, Katalin, Anita Réka Tóth, and Éva Margit Kereszty. "A new designer drug: Methylone related death." Orvosi Hetilap 153, no. 7 (2012): 271–76. http://dx.doi.org/10.1556/oh.2012.29310.

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This report presents a fatal case related to the consumption of methylone, a relatively new cathinone type designer drug. A 16-year-old boy suddenly lost his consciousness in a party. Resuscitation had been continued for about 1.5 hours at the intensive care unit, but it was unsuccessful. His previous history included cardiac malformation detected at infancy and bronchial asthma had been diagnosed one year before his death. Signs of sudden cardiac death were observed during autopsy. Methylone intake was proved in blood and liver extract using gas chromatography/mass spectrometry; its concentra

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9

Sogawa, Chiharu, Norio Sogawa, Kazumi Ohyama, et al. "Methylone and Monoamine Transporters: Correlation with Toxicity." Current Neuropharmacology 9, no. 1 (2011): 58–62. http://dx.doi.org/10.2174/157015911795017425.

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10

Carbone, Peter, David L. Carbone, Shaun Carstairs, and Scott A. Luzi. "Sudden Cardiac Death Associated With Methylone Use." American Journal of Clinical Pathology 138, suppl 2 (2012): A320. http://dx.doi.org/10.1093/ajcp/138.suppl2.50.

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11

Carbone, Peter N., David L. Carbone, Shaun D. Carstairs, and Scott A. Luzi. "Sudden Cardiac Death Associated With Methylone Use." American Journal of Forensic Medicine and Pathology 34, no. 1 (2013): 26–28. http://dx.doi.org/10.1097/paf.0b013e31827ab5da.

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12

Cawrse, B. M., B. Levine, R. A. Jufer, et al. "Distribution of Methylone in Four Postmortem Cases." Journal of Analytical Toxicology 36, no. 6 (2012): 434–39. http://dx.doi.org/10.1093/jat/bks046.

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13

Watterson, Lucas R., and M. Foster Olive. "Synthetic Cathinones and Their Rewarding and Reinforcing Effects in Rodents." Advances in Neuroscience 2014 (June 4, 2014): 1–9. http://dx.doi.org/10.1155/2014/209875.

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Synthetic cathinones, colloquially referred to as “bath salts,” are derivatives of the psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid-to-late 2000s, these amphetamine-like psychostimulants have gained popularity amongst drug users due to their potency, low cost, ease of procurement, and constantly evolving chemical structures. Concomitant with their increased use is the emergence of a growing collection of case reports of bizarre and dangerous behaviors, toxicity to numerous organ systems, and death. However, scientific information regarding the abuse liability of

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14

Shimizu, Eiji, Hiroyuki Watanabe, Takashi Kojima, et al. "Combined intoxication with methylone and 5-MeO-MIPT." Progress in Neuro-Psychopharmacology and Biological Psychiatry 31, no. 1 (2007): 288–91. http://dx.doi.org/10.1016/j.pnpbp.2006.06.012.

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15

Bossong, M., J. Van Dijk, and R. Niesink. "Methylone and mCPP, two new drugs of abuse?" Addiction Biology 10, no. 4 (2005): 321–23. http://dx.doi.org/10.1080/13556210500350794.

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16

Pedersen, Anders Just, Trine Hedebrink Petersen, and Kristian Linnet. "In Vitro Metabolism and Pharmacokinetic Studies on Methylone." Drug Metabolism and Disposition 41, no. 6 (2013): 1247–55. http://dx.doi.org/10.1124/dmd.112.050880.

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17

Warrick, Brandon J., John Wilson, Matthew Hedge, Scott Freeman, Karen Leonard, and Cynthia Aaron. "Lethal Serotonin Syndrome After Methylone and Butylone Ingestion." Journal of Medical Toxicology 8, no. 1 (2011): 65–68. http://dx.doi.org/10.1007/s13181-011-0199-6.

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18

Spálovská, Dita, Tereza Maříková, Michal Kohout, František Králík, Martin Kuchař, and Vladimír Setnička. "Methylone and pentylone: structural analysis of new psychoactive substances." Forensic Toxicology 37, no. 2 (2019): 366–77. http://dx.doi.org/10.1007/s11419-019-00468-z.

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19

Boulanger-Gobeil, Cindy, Maude St-Onge, Martin Laliberté, and Pierre L. Auger. "Seizures and Hyponatremia Related to Ethcathinone and Methylone Poisoning." Journal of Medical Toxicology 8, no. 1 (2011): 59–61. http://dx.doi.org/10.1007/s13181-011-0159-1.

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20

Knoy, Justin L., Brianna L. Peterson та Fiona J. Couper. "Suspected Impaired Driving Case Involving α-Pyrrolidinovalerophenone, Methylone and Ethylone". Journal of Analytical Toxicology 38, № 8 (2014): 615–17. http://dx.doi.org/10.1093/jat/bku073.

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21

McIntyre, Iain M., Catherine E. Hamm, Lenore Aldridge, and Craig L. Nelson. "Acute methylone intoxication in an accidental drowning – A case report." Forensic Science International 231, no. 1-3 (2013): e1-e3. http://dx.doi.org/10.1016/j.forsciint.2013.06.005.

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22

Javadi-Paydar, Mehrak, Jacques D. Nguyen, Sophia A. Vandewater, Tobin J. Dickerson, and Michael A. Taffe. "Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats." Neuropharmacology 134 (May 2018): 57–64. http://dx.doi.org/10.1016/j.neuropharm.2017.09.002.

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23

Creehan, Kevin M., Sophia A. Vandewater, and Michael A. Taffe. "Intravenous self-administration of mephedrone, methylone and MDMA in female rats." Neuropharmacology 92 (May 2015): 90–97. http://dx.doi.org/10.1016/j.neuropharm.2015.01.003.

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24

Couto, Rosa A. S., Bassim Mounssef, Félix Carvalho, et al. "Methylone screening with electropolymerized molecularly imprinted polymer on screen-printed electrodes." Sensors and Actuators B: Chemical 316 (August 2020): 128133. http://dx.doi.org/10.1016/j.snb.2020.128133.

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25

López-Arnau, Raul, Jose Martínez-Clemente, David Pubill, Elena Escubedo, and Jorge Camarasa. "Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone." British Journal of Pharmacology 167, no. 2 (2012): 407–20. http://dx.doi.org/10.1111/j.1476-5381.2012.01998.x.

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26

Heather, Erin, Adam Bortz, Ronald Shimmon, and Andrew M. McDonagh. "Organic impurity profiling of methylone and intermediate compounds synthesized from catechol." Drug Testing and Analysis 9, no. 3 (2017): 436–45. http://dx.doi.org/10.1002/dta.2140.

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27

Araújo, Ana Margarida, Márcia Carvalho, Maria de Lourdes Bastos, Félix Carvalho, and Paula Guedes de Pinho. "Metabolic signature of methylone in primary mouse hepatocytes, at subtoxic concentrations." Archives of Toxicology 93, no. 11 (2019): 3277–90. http://dx.doi.org/10.1007/s00204-019-02566-8.

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28

Valente, M. J., A. M. Araújo, R. Silva, et al. "Hepatic oxidative stress induced by methylone and MDPV: A comparison to MDMA." Toxicology Letters 238, no. 2 (2015): S265. http://dx.doi.org/10.1016/j.toxlet.2015.08.765.

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29

Elmore, Joshua S., Ora Dillon-Carter, John S. Partilla, et al. "Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats." Neuropsychopharmacology 42, no. 3 (2016): 649–60. http://dx.doi.org/10.1038/npp.2016.213.

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30

Kamata, H. T., N. Shima, K. Zaitsu, et al. "Metabolism of the recently encountered designer drug, methylone, in humans and rats." Xenobiotica 36, no. 8 (2006): 709–23. http://dx.doi.org/10.1080/00498250600780191.

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31

Karlsson, Louise, Mikael Andersson, Robert Kronstrand, and Fredrik C. Kugelberg. "Mephedrone, Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice." Basic & Clinical Pharmacology & Toxicology 115, no. 5 (2014): 411–16. http://dx.doi.org/10.1111/bcpt.12253.

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32

Kikura-Hanajiri, Ruri, Maiko Kawamura, Kazuhiro Saisho, Yukio Kodama, and Yukihiro Goda. "The disposition into hair of new designer drugs; methylone, MBDB and methcathinone." Journal of Chromatography B 855, no. 2 (2007): 121–26. http://dx.doi.org/10.1016/j.jchromb.2007.05.018.

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33

Zona, Luke C., Gregory G. Grecco, and Jon E. Sprague. "Cooling down the bath salts: Carvedilol attenuation of methylone and mephedrone mediated hyperthermia." Toxicology Letters 263 (November 2016): 11–15. http://dx.doi.org/10.1016/j.toxlet.2016.10.012.

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34

Silva, B., C. Fernandes, M. Pinto, P. Guedes de Pinho, and F. Remião. "Enantioresolution of pentedrone and methylone and in vitro dopaminergic SH-SY5Y cytotoxicity studies." Toxicology Letters 295 (October 2018): S269. http://dx.doi.org/10.1016/j.toxlet.2018.07.030.

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35

López-Arnau, Raúl, José Martínez-Clemente, David Pubill, Elena Escubedo, and Jorge Camarasa. "Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone." Journal of Psychopharmacology 28, no. 11 (2014): 1053–63. http://dx.doi.org/10.1177/0269881114548439.

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36

Nguyen, Jacques D., Yanabel Grant, Kevin M. Creehan, Sophia A. Vandewater, and Michael A. Taffe. "Escalation of intravenous self-administration of methylone and mephedrone under extended access conditions." Addiction Biology 22, no. 5 (2016): 1160–68. http://dx.doi.org/10.1111/adb.12398.

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37

Goldsmith, Robert, Sudhan Pachhain, Sayantan Roy Choudhury, Vipa Phuntumart, Ray Larsen, and Jon E. Sprague. "Gender differences in tolerance to the hyperthermia mediated by the synthetic cathinone methylone." Temperature 6, no. 4 (2019): 334–40. http://dx.doi.org/10.1080/23328940.2019.1648988.

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38

Silva, Bárbara, José A. Pereira, Sara Cravo, et al. "Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers." Journal of Chromatography B 1100-1101 (November 2018): 158–64. http://dx.doi.org/10.1016/j.jchromb.2018.10.002.

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39

Grifell, M., L. Galindo, M. Ventura, et al. "The cat and the mouse game: Is there a shift towards more dangerous substances in the cathinone illicit market?" European Psychiatry 41, S1 (2017): s863. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1726.

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IntroductionAfter mephedrone's ban in March 2010 new cathinones proliferated widely, even a new branch of atypical derivatives was launched into the market, represented by MDPV. The cardiovascular and central nervous system toxicity draws attention to this new family of cathinones, also known as pyrovalerones. MDPV was scheduled in 2011, leading to the apparition of Alpha-PVP from which there is little information.ObjectivesThe aim of the present study is to describe the evolution of different cathinones in the samples delivered for analysis to the harm reduction NGO energy control from March

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40

Wakeford, Alison G. P., Alexander M. Sherwood, Thomas E. Prisinzano, Jack Bergman, Stephen J. Kohut, and Carol A. Paronis. "Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys." International Journal of Neuropsychopharmacology 24, no. 8 (2021): 656–65. http://dx.doi.org/10.1093/ijnp/pyab017.

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Abstract Background Synthetic cathinones display overlapping behavioral effects with psychostimulants (e.g., methamphetamine [MA]) and/or entactogens (e.g., 3,4-methylenedioxymethaphetamine [MDMA])—presumably reflecting their dopaminergic and/or serotonergic activity. The discriminative stimulus effects of MDMA thought to be mediated by such activity have been well characterized in rodents but have not been fully examined in nonhuman primates. Methods The present studies were conducted to systematically evaluate the discriminative stimulus effects of 5 abused synthetic cathinones (methylenedio

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41

Antsyborov, Andrey Viktorovich, and Azat Railevich Asadulin. "Psychoactive effects and toxic reactions associated with the use of mephedrone and methylone (review)." Interactive science, no. 9 (19) (September 21, 2017): 24–31. http://dx.doi.org/10.21661/r-463419.

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42

den Hollander, Bjørnar, Stanislav Rozov, Anni-Maija Linden, Mikko Uusi-Oukari, Ilkka Ojanperä, and Esa R. Korpi. "Long-term cognitive and neurochemical effects of “bath salt” designer drugs methylone and mephedrone." Pharmacology Biochemistry and Behavior 103, no. 3 (2013): 501–9. http://dx.doi.org/10.1016/j.pbb.2012.10.006.

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43

Shimomura, Eric T., Alice J. Briones, Wendy S. Warren, et al. "Case Report of Methylone, Oxymorphone and Ethanol in a Fatality Case with Tissue Distribution." Journal of Analytical Toxicology 40, no. 7 (2016): 543–45. http://dx.doi.org/10.1093/jat/bkw045.

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44

Daniel, Jollee J., and Robert N. Hughes. "Increased anxiety and impaired spatial memory in young adult rats following adolescent exposure to methylone." Pharmacology Biochemistry and Behavior 146-147 (July 2016): 44–49. http://dx.doi.org/10.1016/j.pbb.2016.05.003.

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45

Sorribes-Soriano, A., S. Sánchez-Martínez, R. Arráez-González, F. A. Esteve-Turrillas, and S. Armenta. "Methylone determination in oral fluid using microextraction by packed sorbent coupled to ion mobility spectrometry." Microchemical Journal 153 (March 2020): 104504. http://dx.doi.org/10.1016/j.microc.2019.104504.

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46

Baumann, Michael H., Mario A. Ayestas, John S. Partilla, et al. "The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue." Neuropsychopharmacology 37, no. 5 (2011): 1192–203. http://dx.doi.org/10.1038/npp.2011.304.

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47

Luethi, Dino, Karolina E. Kolaczynska, Melanie Walter, et al. "Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems." Journal of Psychopharmacology 33, no. 7 (2019): 831–41. http://dx.doi.org/10.1177/0269881119844185.

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48

Weiss, Stephanie, Regina Seidl, Waltraud Kessler, Rudolf W. Kessler, Edith M. Zikulnig-Rusch, and Andreas Kandelbauer. "Unravelling the Phases of Melamine Formaldehyde Resin Cure by Infrared Spectroscopy (FTIR) and Multivariate Curve Resolution (MCR)." Polymers 12, no. 11 (2020): 2569. http://dx.doi.org/10.3390/polym12112569.

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Here, we study resin cure and network formation of solid melamine formaldehyde pre-polymer over a large temperature range via dynamic temperature curing profiles. Real-time infrared spectroscopy is used to analyze the chemical changes during network formation and network hardening. By applying chemometrics (multivariate curve resolution, MCR), the essential chemical functionalities that constitute the network at a given stage of curing are mathematically extracted and tracked over time. The three spectral components identified by MCR were methylol-rich, ether linkages-rich and methylene linkag

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49

Araújo, A. M., M. D. L. Bastos, F. Carvalho, M. Carvalho, and P. Guedes de Pinho. "Metabolomic analysis of the toxicity pathways elicited by subtoxic concentrations of methylone in primary mouse hepatocytes." Toxicology Letters 295 (October 2018): S267. http://dx.doi.org/10.1016/j.toxlet.2018.07.026.

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50

Poklis, Justin L., Carl E. Wolf, Omar I. ElJordi, Kai Liu, Shijun Zhang, and Alphonse Poklis. "Analysis of the First- and Second-Generation Raving Dragon Novelty Bath Salts Containing Methylone and Pentedrone." Journal of Forensic Sciences 60 (December 2, 2014): S234—S240. http://dx.doi.org/10.1111/1556-4029.12629.

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