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Artigos de revistas sobre o tema "Microfluidic processes"

Autor: Grafiati

Publicado: 14 de dezembro de 2024

Última modificação: 19 de julho de 2025

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1

Babikian, Sarkis, Brian Soriano, G. P. Li, and Mark Bachman. "Laminate Materials for Microfluidic PCBs." International Symposium on Microelectronics 2012, no. 1 (2012): 000162–68. http://dx.doi.org/10.4071/isom-2012-ta54.

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The printed circuit board (PCB) is a very attractive platform to produce highly integrated highly functional microfluidic devices. We have investigated laminate materials and developed novel fabrication processes to realize low cost and scalable to manufacturing integrated microfluidics on PCBs. In this paper we describe our vision to integrate functional components with microfluidic channels. We also report on the use of Ethylene Vinyl Acetate (EVA) as a laminate for microfluidics. The material was characterized for microfluidic applications and compared with our previously reported laminates

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Bianchi, Jhonatan Rafael de Oliveira, Lucimara Gaziola de la Torre, and Ana Leticia Rodrigues Costa. "Droplet-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type." Foods 12, no. 18 (2023): 3385. http://dx.doi.org/10.3390/foods12183385.

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Microfluidic technology has emerged as a powerful tool for several applications, including chemistry, physics, biology, and engineering. Due to the laminar regime, droplet-based microfluidics enable the development of diverse delivery systems based on food-grade emulsions, such as multiple emulsions, microgels, microcapsules, solid lipid microparticles, and giant liposomes. Additionally, by precisely manipulating fluids on the low-energy-demand micrometer scale, it becomes possible to control the size, shape, and dispersity of generated droplets, which makes microfluidic emulsification an exce

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Alexandre-Franco, María F., Rahmani Kouider, Raúl Kassir Al-Karany, Eduardo M. Cuerda-Correa, and Awf Al-Kassir. "Recent Advances in Polymer Science and Fabrication Processes for Enhanced Microfluidic Applications: An Overview." Micromachines 15, no. 9 (2024): 1137. http://dx.doi.org/10.3390/mi15091137.

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This review explores significant advancements in polymer science and fabrication processes that have enhanced the performance and broadened the application scope of microfluidic devices. Microfluidics, essential in biotechnology, medicine, and chemical engineering, relies on precise fluid manipulation in micrometer-sized channels. Recent innovations in polymer materials, such as flexible, biocompatible, and structurally robust polymers, have been pivotal in developing advanced microfluidic systems. Techniques like replica molding, microcontact printing, solvent-assisted molding, injection mold

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Bouhid de Aguiar, Izabella, and Karin Schroën. "Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes." Membranes 10, no. 11 (2020): 316. http://dx.doi.org/10.3390/membranes10110316.

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Membrane filtration processes are best known for their application in the water, oil, and gas sectors, but also in food production they play an eminent role. Filtration processes are known to suffer from a decrease in efficiency in time due to e.g., particle deposition, also known as fouling and pore blocking. Although these processes are not very well understood at a small scale, smart engineering approaches have been used to keep membrane processes running. Microfluidic devices have been increasingly applied to study membrane filtration processes and accommodate observation and understanding

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Prajitna, Stefanus H., Christian Harito, and Brian Yuliarto. "Cost-Effective Manufacturing of Microfluidics Through the Utilization of Direct Ink Writing." Emerging Science Journal 9, no. 1 (2025): 1–11. https://doi.org/10.28991/esj-2025-09-01-01.

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Microfluidics is essential for precise manipulation of fluids in small channels. However, conventional manufacturing processes for microfluidic devices are expensive, time-consuming, and require specialized equipment in a clean room. While recent studies have improved the cost-effectiveness of this device, there is still a need for further advancement in cost efficiency. Therefore, this study aimed to develop a custom-built direct-ink writing (DIW) printer for manufacturing microfluidic devices that is more affordable. Custom-built DIW directly printed microfluidic channels onto microscope sli

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Giri, Kiran, and Chia-Wen Tsao. "Recent Advances in Thermoplastic Microfluidic Bonding." Micromachines 13, no. 3 (2022): 486. http://dx.doi.org/10.3390/mi13030486.

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Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechanical rigidity, organic solvent resistivity, acid/base resistivity, and low water absorbance make thermoplastics suitable for various microfluidic applications. However, bonding of thermoplastics has always been challenging because of a wide range of bonding methods and requirements. This review paper summarizes the current bonding processes being p

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Tsur, Elishai Ezra. "Computer-Aided Design of Microfluidic Circuits." Annual Review of Biomedical Engineering 22, no. 1 (2020): 285–307. http://dx.doi.org/10.1146/annurev-bioeng-082219-033358.

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Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The field includes the development of new description languages, optimization methods, benchmarks, and integrated design tools. Here, recent advancements are reviewed in the computer-aided design of f

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Marzban, Mostapha, Ehsan Yazdanpanah Moghadam, Javad Dargahi, and Muthukumaran Packirisamy. "Microfabrication Bonding Process Optimization for a 3D Multi-Layer PDMS Suspended Microfluidics." Applied Sciences 12, no. 9 (2022): 4626. http://dx.doi.org/10.3390/app12094626.

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Microfluidic systems have received increased attention due to their wide variety of applications, from chemical sensing to biological detection to medical analysis. Microfluidics used to be fabricated by using etching techniques that required cleanroom and aggressive chemicals. However, another microfluidic fabrication technique, namely, soft lithography, is less expensive and safer compared to former techniques. Polydimethylsiloxane (PDMS) has been widely employed as a fabrication material in microfluidics by using soft lithography as it is transparent, soft, bio-compatible, and inexpensive.

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Naderi, Arman, Nirveek Bhattacharjee, and Albert Folch. "Digital Manufacturing for Microfluidics." Annual Review of Biomedical Engineering 21, no. 1 (2019): 325–64. http://dx.doi.org/10.1146/annurev-bioeng-092618-020341.

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The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology—and its impact on society—is in jeopardy. Digital manufacturing (DM) refers to a family of computer-centered processes that integrate digital three-dimensional (3D) designs, automated (additive or subtractive) fabricatio

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Cha, Haotian, Hedieh Fallahi, Yuchen Dai, et al. "Multiphysics microfluidics for cell manipulation and separation: a review." Lab on a Chip 22, no. 3 (2022): 423–44. http://dx.doi.org/10.1039/d1lc00869b.

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We reviewed the state-of-the-art field of multiphysics microfluidics, in which multiple functional physical processes are combined in a microfluidic platform, examining the different formats of cascaded connections and physical coupling.

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Kurniawan, Yehezkiel Steven, Arif Cahyo Imawan, Sathuluri Ramachandra Rao, et al. "Microfluidics Era in Chemistry Field: A Review." Journal of the Indonesian Chemical Society 2, no. 1 (2019): 7. http://dx.doi.org/10.34311/jics.2019.02.1.7.

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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based

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BAI, BOFENG, ZHENGYUAN LUO, TIANJIAN LU, and FENG XU. "NUMERICAL SIMULATION OF CELL ADHESION AND DETACHMENT IN MICROFLUIDICS." Journal of Mechanics in Medicine and Biology 13, no. 01 (2013): 1350002. http://dx.doi.org/10.1142/s0219519413500024.

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Inspired by the complex biophysical processes of cell adhesion and detachment under blood flow in vivo, numerous novel microfluidic devices have been developed to manipulate, capture, and separate bio-particles for various applications, such as cell analysis and cell enumeration. However, the underlying physical mechanisms are yet unclear, which has limited the further development of microfluidic devices and point-of-care (POC) systems. Mathematical modeling is an enabling tool to study the physical mechanisms of biological processes for its relative simplicity, low cost, and high efficiency.

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Carvalho, Bruna G., Bruno T. Ceccato, Mariano Michelon, Sang W. Han, and Lucimara G. de la Torre. "Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application." Pharmaceutics 14, no. 1 (2022): 141. http://dx.doi.org/10.3390/pharmaceutics14010141.

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Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nano

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Vitorino, Rui, Sofia Guedes, João Pinto da Costa, and Václav Kašička. "Microfluidics for Peptidomics, Proteomics, and Cell Analysis." Nanomaterials 11, no. 5 (2021): 1118. http://dx.doi.org/10.3390/nano11051118.

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Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In p

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Chen, Yu-Shih, Chun-Hao Huang, Ping-Ching Pai, Jungmok Seo, and Kin Fong Lei. "A Review on Microfluidics-Based Impedance Biosensors." Biosensors 13, no. 1 (2023): 83. http://dx.doi.org/10.3390/bios13010083.

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Electrical impedance biosensors are powerful and continuously being developed for various biological sensing applications. In this line, the sensitivity of impedance biosensors embedded with microfluidic technologies, such as sheath flow focusing, dielectrophoretic focusing, and interdigitated electrode arrays, can still be greatly improved. In particular, reagent consumption reduction and analysis time-shortening features can highly increase the analytical capabilities of such biosensors. Moreover, the reliability and efficiency of analyses are benefited by microfluidics-enabled automation. T

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Bhavana, Patil*1 Mansi Choudhary2 Alok Mishra3 Paramprit Singh4 Dipesh Tripathi5. "Microfluidic Technology Advances: "Fabrication and Applications of Microfluidic Devices: A comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3227–48. https://doi.org/10.5281/zenodo.15111201.

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science.  Microfluidic chips can be utilized in cell analysis, diagnostics, cell culture, drug encapsulation, delivery, and targeting, as well as in the creation of nanoparticles, either alone or in conjunction with other devices. The manipulation of small fluid volumes, usually nanolitres or less, within networks of channels with tens to hundreds of micro meters in diameter is the focus of microfluidics. These devices enable the

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Lifton, Victor A. "Microfluidics: an enabling screening technology for enhanced oil recovery (EOR)." Lab on a Chip 16, no. 10 (2016): 1777–96. http://dx.doi.org/10.1039/c6lc00318d.

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Recent applications of microfluidics and microtechnology are reviewed to show that microfluidic devices can be useful tools in investigation and visualization of such processes used in the Oil & Gas industry as enhanced oil recovery, fluid propagation, flooding, fracturing, emulsification and many others.

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Acosta-Cuevas, José M., Mario A. García-Ramírez, Gabriela Hinojosa-Ventura, Álvaro J. Martínez-Gómez, Víctor H. Pérez-Luna, and Orfil González-Reynoso. "Surface Roughness Analysis of Microchannels Featuring Microfluidic Devices Fabricated by Three Different Materials and Methods." Coatings 13, no. 10 (2023): 1676. http://dx.doi.org/10.3390/coatings13101676.

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In recent years, the utilization of microfluidic devices for precise manipulation of small flows has significantly increased. The effective management of microfluidics is closely associated with microchannel fabrication. The fabrication method employed for microfluidic devices directly impacts the roughness of the microchannels, consequently influencing the flows within them. In this study, the surface roughness of microchannels was investigated through three different fabrication processes: PDMS lithography, PLA printing, and UV resin printing. This research compared and analyzed the surface

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Roy, Sanjib, Ramesh Kumar, Argha Acooli, et al. "Transforming Nanomaterial Synthesis through Advanced Microfluidic Approaches: A Review on Accessing Unrestricted Possibilities." Journal of Composites Science 8, no. 10 (2024): 386. http://dx.doi.org/10.3390/jcs8100386.

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The inception of microfluidic devices marks a confluence of diverse scientific domains, including physics, biology, chemistry, and fluid mechanics. These multidisciplinary roots have catalyzed the evolution of microfluidic devices, which serve as versatile platforms for various chemical and biological processes. Notably, microfluidic devices have garnered attention as efficient reactors, offering distinct benefits such as minimized spatial requirements for reactions, reduced equipment costs, and accelerated residence times. These advantages, among others, have ignited a compelling interest in

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Dai, Chuankai, Xiaoming Liu, Rongyu Tang, Jiping He, and Tatsuo Arai. "A Review on Microfluidic Platforms Applied to Nerve Regeneration." Applied Sciences 12, no. 7 (2022): 3534. http://dx.doi.org/10.3390/app12073534.

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In recent decades, microfluidics have significantly advanced nerve regeneration research. Microfluidic devices can provide an accurate simulation of in vivo microenvironment for different research purposes such as analyzing myelin growth inhibitory factors, screening drugs, assessing nerve growth factors, and exploring mechanisms of neural injury and regeneration. The microfluidic platform offers technical supports for nerve regeneration that enable precise spatio-temporal control of cells, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance. In this paper,

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Liu, Xing, and Xiaolin Zheng. "Microfluidic-Based Electrical Operation and Measurement Methods in Single-Cell Analysis." Sensors 24, no. 19 (2024): 6359. http://dx.doi.org/10.3390/s24196359.

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Cellular heterogeneity plays a significant role in understanding biological processes, such as cell cycle and disease progression. Microfluidics has emerged as a versatile tool for manipulating single cells and analyzing their heterogeneity with the merits of precise fluid control, small sample consumption, easy integration, and high throughput. Specifically, integrating microfluidics with electrical techniques provides a rapid, label-free, and non-invasive way to investigate cellular heterogeneity at the single-cell level. Here, we review the recent development of microfluidic-based electrica

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Savitri, Goparaju. "Advancement in Generation and Application of Microfluidic Chip Technology." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 2 (2024): 7277–98. http://dx.doi.org/10.37285/ijpsn.2024.17.2.9.

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Microfluidics is an interdisciplinary topic of research that draws inspiration from other areas such as fluid dynamics, microelectronics, materials science, and physics. Microfluidics has made it possible to create microscale channels and chambers out of a broad variety of materials by borrowing ideas from a number of different fields. This has opened up exciting possibilities for the development of platforms of any size, shape, and geometry using a variety of approaches. One of the most significant advantages of microfluidics is its versatility in applications. Microfluidic chips can be used

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Hamad, Eyad M., Ahmed Albagdady, Samer Al-Gharabli, et al. "Optimizing Rapid Prototype Development Through Femtosecond Laser Ablation and Finite Element Method Simulation for Enhanced Separation in Microfluidics." Journal of Nanofluids 12, no. 7 (2023): 1868–79. http://dx.doi.org/10.1166/jon.2023.2102.

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In recent years, microfluidic systems have emerged as promising tools for blood separation and analysis. However, conventional methods for prototyping microfluidic systems can be slow and expensive. In this study, we present a novel approach to rapid prototyping that combines femtosecond laser ablation and finite element method (FEM) simulation. The optimization of the prototyping process was achieved through systematic characterization of the laser ablation process and the application of FEM simulation to predict the flow behavior of the microfluidic devices. Using a dean-coupled inertial flo

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Mu, Ruojun, Nitong Bu, Jie Pang, Lin Wang, and Yue Zhang. "Recent Trends of Microfluidics in Food Science and Technology: Fabrications and Applications." Foods 11, no. 22 (2022): 3727. http://dx.doi.org/10.3390/foods11223727.

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The development of novel materials with microstructures is now a trend in food science and technology. These microscale materials may be applied across all steps in food manufacturing, from raw materials to the final food products, as well as in the packaging, transport, and storage processes. Microfluidics is an advanced technology for controlling fluids in a microscale channel (1~100 μm), which integrates engineering, physics, chemistry, nanotechnology, etc. This technology allows unit operations to occur in devices that are closer in size to the expected structural elements. Therefore, micr

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Sun, Yueqiu, Nianzuo Yu, Junhu Zhang, and Bai Yang. "Advances in Microfluidic Single-Cell RNA Sequencing and Spatial Transcriptomics." Micromachines 16, no. 4 (2025): 426. https://doi.org/10.3390/mi16040426.

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The development of micro- and nano-fabrication technologies has greatly advanced single-cell and spatial omics technologies. With the advantages of integration and compartmentalization, microfluidic chips are capable of generating high-throughput parallel reaction systems for single-cell screening and analysis. As omics technologies improve, microfluidic chips can now integrate promising transcriptomics technologies, providing new insights from molecular characterization for tissue gene expression profiles and further revealing the static and even dynamic processes of tissues in homeostasis an

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Kotz, Frederik, Markus Mader, Nils Dellen, et al. "Fused Deposition Modeling of Microfluidic Chips in Polymethylmethacrylate." Micromachines 11, no. 9 (2020): 873. http://dx.doi.org/10.3390/mi11090873.

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Polymethylmethacrylate (PMMA) is one of the most important thermoplastic materials and is a widely used material in microfluidics. However, PMMA is usually structured using industrial scale replication processes, such as hot embossing or injection molding, not compatible with rapid prototyping. In this work, we demonstrate that microfluidic chips made from PMMA can be 3D printed using fused deposition modeling (FDM). We demonstrate that using FDM microfluidic chips with a minimum channel cross-section of ~300 µm can be printed and a variety of different channel geometries and mixer structures

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Lundy, Terence. "Advanced Confocal Microscopy An Essential Technique for Microfluidics Development." Microscopy Today 14, no. 1 (2006): 8–13. http://dx.doi.org/10.1017/s1551929500055127.

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Many believe that microfluidics has the potential to do for chemistry and biology what the integrated circuit has done for electronics — integrating tremendously complex chemical and biological processes into simple easy-to-use devices that will eventually pervade our lives. While microfluidics has made great progress in the last decade — addressing many of the fundamental questions related to manipulating nanoliter volumes of chemicals and solutions — it still faces some very basic challenges as it moves out of the laboratory and into use. Perhaps most basic is the need for fast, accurate cha

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Mea, H., and J. Wan. "Microfluidics-enabled functional 3D printing." Biomicrofluidics 16, no. 2 (2022): 021501. http://dx.doi.org/10.1063/5.0083673.

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Microfluidic technology has established itself as a powerful tool to enable highly precise spatiotemporal control over fluid streams for mixing, separations, biochemical reactions, and material synthesis. 3D printing technologies such as extrusion-based printing, inkjet, and stereolithography share similar length scales and fundamentals of fluid handling with microfluidics. The advanced fluidic manipulation capabilities afforded by microfluidics can thus be potentially leveraged to enhance the performance of existing 3D printing technologies or even develop new approaches to additive manufactu

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Mumtaz, Zilwa, Zubia Rashid, Ashaq Ali, et al. "Prospects of Microfluidic Technology in Nucleic Acid Detection Approaches." Biosensors 13, no. 6 (2023): 584. http://dx.doi.org/10.3390/bios13060584.

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Conventional diagnostic techniques are based on the utilization of analyte sampling, sensing and signaling on separate platforms for detection purposes, which must be integrated to a single step procedure in point of care (POC) testing devices. Due to the expeditious nature of microfluidic platforms, the trend has been shifted toward the implementation of these systems for the detection of analytes in biochemical, clinical and food technology. Microfluidic systems molded with substances such as polymers or glass offer the specific and sensitive detection of infectious and noninfectious disease

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Tang, Xiaoqing, Qiang Huang, Tatsuo Arai, and Xiaoming Liu. "Cell pairing for biological analysis in microfluidic devices." Biomicrofluidics 16, no. 6 (2022): 061501. http://dx.doi.org/10.1063/5.0095828.

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Cell pairing at the single-cell level usually allows a few cells to contact or seal in a single chamber and provides high-resolution imaging. It is pivotal for biological research, including understanding basic cell functions, creating cancer treatment technologies, developing drugs, and more. Laboratory chips based on microfluidics have been widely used to trap, immobilize, and analyze cells due to their high efficiency, high throughput, and good biocompatibility properties. Cell pairing technology in microfluidic devices provides spatiotemporal research on cellular interactions and a highly

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Ren, Liqing, and Dongqing Li. "Theoretical Studies of Microfluidic Dispensing Processes." Journal of Colloid and Interface Science 254, no. 2 (2002): 384–95. http://dx.doi.org/10.1006/jcis.2002.8645.

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Daugbjerg, Thomas Schrøder, Loïc Crouzier, Alexandra Delvallée, et al. "Measurement of wettability and surface roughness for metrology and quality control in microfluidics." International Journal of Metrology and Quality Engineering 16 (2025): 2. https://doi.org/10.1051/ijmqe/2024021.

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Microfluidics is a rapidly growing technology with applications in biochemistry and life sciences. To support the ongoing growth there is a need for common metrology, quality control, and standardisation. Here measurements of wettability and surface roughness can contribute, and these quantities affect flow characteristics of devices, bonding processes in manufacturing, and special microfluidic mechanisms such as droplet formation and spreading of fluids on surfaces. To quantify wettability, an optical laboratory setup was used to measure liquid drop contact angles of three liquids on a microf

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Renkó, József Bálint, Attila Bonyár, and Péter János Szabó. "Development of Microfluidic Cell for Liquid Phase Layer Deposition Tracking." Acta Materialia Transylvanica 3, no. 2 (2020): 94–97. http://dx.doi.org/10.33924/amt-2020-02-08.

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Abstract This paper shows how microfluidic tools can be used for up-to-date microstructural investigations based on thin film deposition. The construction and production methods of such measuring procedures are introduced, and their application in ellipsometric investigations is shown. By using these tools, the researchers provide the possibility to observe and document the effects of certain fine structural processes in the development of the final microstructure. This paper describes two specific application areas of such microfluidics cells. Microfluidics cells can be used together with bot

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Sri, Sowmya Veeravalli* Bhaskararaju vatchavai Soni Saisri Bandi Roshini Teja Manikanteshwari Bobbili Shaman Mohammad Lakshmanudu Bhukya. "The Microfluidic Revolution in Medical Diagnostics." International Journal Of Pharmaceutical Sciences 2, no. 12 (2024): 2803–10. https://doi.org/10.5281/zenodo.14542487.

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A fast expanding field that has completely changed the way we think about healthcare is microfluidics. Small quantities of fluids, usually measured in microliters or nanoliters, are manipulated in tiny chambers or channels that are integrated into a microchip. Because of its high resolution, automation, low cost, and capacity to conduct diagnostic tests with small sample volumes, microfluidic devices have emerged as attractive point-of-care (POC) and customized medicine tools.Many of the most advanced medical diagnostic technologies are unavailable in developing nations; these technologies wer

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Erfantalab, Sobhan, Ali Hooshyar Zare, and Amin Jenabi. "Ambient Temperature Dependence of Diffusion Rate in a Microfluidic Channel." Key Engineering Materials 605 (April 2014): 127–30. http://dx.doi.org/10.4028/www.scientific.net/kem.605.127.

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Microfluidics offers methods of miniaturization for numerous chemical, electrochemical and biological processes. Thermal diffusion of molecular species through microfluidic channels is involved in many of such processes. High specific surface in microchannels complicates the theoretical assessment of diffusion rate in such channels as both the diffusion coefficient and the physisorption rate to the channel walls are temperature-sensitive. In this work, it is shown that both of these parameters vary in the same direction with temperature and the superposition of their respective effects makes t

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Yip, Hon Ming, John C. S. Li, Kai Xie, et al. "Automated Long-Term Monitoring of Parallel Microfluidic Operations Applying a Machine Vision-Assisted Positioning Method." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/608184.

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As microfluidics has been applied extensively in many cell and biochemical applications, monitoring the related processes is an important requirement. In this work, we design and fabricate a high-throughput microfluidic device which contains 32 microchambers to perform automated parallel microfluidic operations and monitoring on an automated stage of a microscope. Images are captured at multiple spots on the device during the operations for monitoring samples in microchambers in parallel; yet the device positions may vary at different time points throughout operations as the device moves back

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Gelado, Sofia H., César Quilodrán-Casas, and Loïc Chagot. "Enhancing Microdroplet Image Analysis with Deep Learning." Micromachines 14, no. 10 (2023): 1964. http://dx.doi.org/10.3390/mi14101964.

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Microfluidics is a highly interdisciplinary field where the integration of deep-learning models has the potential to streamline processes and increase precision and reliability. This study investigates the use of deep-learning methods for the accurate detection and measurement of droplet diameters and the image restoration of low-resolution images. This study demonstrates that the Segment Anything Model (SAM) provides superior detection and reduced droplet diameter error measurement compared to the Circular Hough Transform, which is widely implemented and used in microfluidic imaging. SAM drop

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Smeraldo, Alessio, Alfonso Maria Ponsiglione, Paolo Antonio Netti, and Enza Torino. "Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics." Biomedicines 9, no. 11 (2021): 1551. http://dx.doi.org/10.3390/biomedicines9111551.

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Microfluidics is emerging as a promising tool to control physicochemical properties of nanoparticles and to accelerate clinical translation. Indeed, microfluidic-based techniques offer more advantages in nanomedicine over batch processes, allowing fine-tuning of process parameters. In particular, the use of microfluidics to produce nanoparticles has paved the way for the development of nano-scaled structures for improved detection and treatment of several diseases. Here, ionotropic gelation is implemented in a custom-designed microfluidic chip to produce different nanoarchitectures based on ch

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Varghese, Stefna, Dr Poonam Parashar, and Dr. Pragya. "Applications of Microfluidics in Biomedical and Pharmaceutical Fields-An Overview." International Journal of Preventive Medicine and Health 5, no. 4 (2025): 5–10. https://doi.org/10.54105/ijpmh.d1066.05040525.

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The precise manipulation of fluids at the microscale level within minuscule channels measuring tens to hundreds of micrometres is the subject of the multifaceted field of microfluidics. This technology has transformed the pharmaceutical industry by enabling miniaturised, highthroughput, and economical drug discovery, formulation, and delivery solutions. Creating sophisticated drug delivery systems like nanoparticles and liposomes has become far simpler because this method can precisely control fluid dynamics, enabling faster reaction kinetics and better drug encapsulation. Beyond drug formulat

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Dr., Pragya. "Applications of Microfluidics in Biomedical and Pharmaceutical Fields -An Overview." International Journal of Preventive Medicine and Health (IJPMH) 5, no. 4 (2025): 5–10. https://doi.org/10.54105/ijpmh.D1066.05040525/.

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<strong>Abstract: </strong>The precise manipulation of fluids at the microscale level within minuscule channels measuring tens to hundreds of micrometres is the subject of the multifaceted field of microfluidics. This technology has transformed the pharmaceutical industry by enabling miniaturised, highthroughput, and economical drug discovery, formulation, and delivery solutions. Creating sophisticated drug delivery systems like nanoparticles and liposomes has become far simpler because this method can precisely control fluid dynamics, enabling faster reaction kinetics and better drug encapsul

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Zhang, Yuxin, Tim Cole, Guolin Yun, et al. "Modular and Self-Contained Microfluidic Analytical Platforms Enabled by Magnetorheological Elastomer Microactuators." Micromachines 12, no. 6 (2021): 604. http://dx.doi.org/10.3390/mi12060604.

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Portability and low-cost analytic ability are desirable for point-of-care (POC) diagnostics; however, current POC testing platforms often require time-consuming multiple microfabrication steps and rely on bulky and costly equipment. This hinders the capability of microfluidics to prove its power outside of laboratories and narrows the range of applications. This paper details a self-contained microfluidic device, which does not require any external connection or tubing to deliver insert-and-use image-based analysis. Without any microfabrication, magnetorheological elastomer (MRE) microactuator

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42

Birendra Kumar Julee Choudhary, Sundararajan Ananiah Durai, and Nabihah Ahmad. "Smart Microfluidic Devices for Point-Of-Care Applications." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 114, no. 1 (2024): 119–33. http://dx.doi.org/10.37934/arfmts.114.1.119133.

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Microfluidics is an emerging technology vital in the bio-medical sector, encompassing Lab-On-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. Additionally, its day-by-day research studies on drug discovery, cell sorting, and manipulation enrich bio-medical applications. This article provides an overview of the widely used microfluidic devices that are readily available for the commercial sector, improving medical diagnostics with the optimal transduction approaches for Point-Of-Care (POC) applications. On the other hand, some devices still in the development stage

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Vogelaar, Alicia, Samantha Marcotte, Jiaqi Cheng, Benazir Oluoch, and Jennica Zaro. "Use of Microfluidics to Prepare Lipid-Based Nanocarriers." Pharmaceutics 15, no. 4 (2023): 1053. http://dx.doi.org/10.3390/pharmaceutics15041053.

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Lipid-based nanoparticles (LBNPs) are an important tool for the delivery of a diverse set of drug cargoes, including small molecules, oligonucleotides, and proteins and peptides. Despite their development over the past several decades, this technology is still hindered by issues with the manufacturing processes leading to high polydispersity, batch-to-batch and operator-dependent variability, and limits to the production volumes. To overcome these issues, the use of microfluidic techniques in the production of LBNPs has sharply increased over the past two years. Microfluidics overcomes many of

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Pereponov, Dmitrii, Alexandra Scerbacova, Vitaly Kazaku, et al. "Application of microfluidics to optimize oil and gas field development technologies." Kazakhstan journal for oil & gas industry 1, no. 1 (2023): 57–73. http://dx.doi.org/10.54859/kjogi108639.

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To increase the oil recovery factor (RF), enhanced oil recovery (EOR) methods are applied: chemical, gas, thermal, and combined ones. Standard laboratory research methods for selecting and optimizing EOR technologies require a lot of time and resources, as well as core material, which is often in short supply. To optimize the selection of reagents and field development technologies, the use of microfluidic technology is proposed i.e. conducting experiments in reservoir conditions using microfluidic chips with a porous structure, reproducing the properties of the core of the target field. The m

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Sarbashev, K. A., M. V. Nikiforova, D. P. Shulga, M. A. Shishkina, and S. A. Tarasov. "Flow and mixing processes in a passive mixing microfluidic chip: Parameters’ estimation and colorimetric analysis." Fine Chemical Technologies 14, no. 5 (2019): 39–50. http://dx.doi.org/10.32362/2410-6593-2019-14-5-39-50.

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Objectives. The development of microfluidic systems is one of the promising areas of science and technology. In most procedures performed using microfluidic systems, effective mixing in microfluidic channels of microreactors (chips) is of particular importance, because it has an effect on the sensitivity and speed of analytical procedures. The aim of this study is to describe and evaluate the major parameters of the flow and mixing processes in a passive microfluidic micromixer, and to develop an information-measuring system to monitor the dynamics of flow (mixing) of liquids.Methods. This art

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Wu, Haiwa, Jing Zhu, Yao Huang, Daming Wu, and Jingyao Sun. "Microfluidic-Based Single-Cell Study: Current Status and Future Perspective." Molecules 23, no. 9 (2018): 2347. http://dx.doi.org/10.3390/molecules23092347.

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Investigation of cell behavior under different environments and manual operations can give information in specific cellular processes. Among all cell-based analysis, single-cell study occupies a peculiar position, while it can avoid the interaction effect within cell groups and provide more precise information. Microfluidic devices have played an increasingly important role in the field of single-cell study owing to their advantages: high efficiency, easy operation, and low cost. In this review, the applications of polymer-based microfluidics on cell manipulation, cell treatment, and cell anal

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Gao, Run Ze, Vivian Ngoc Tram Mai, Nicholas Levinski, et al. "A novel air microfluidics-enabled soft robotic sleeve: Toward realizing innovative lymphedema treatment." Biomicrofluidics 16, no. 3 (2022): 034101. http://dx.doi.org/10.1063/5.0079898.

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A proof of concept of a novel air microfluidics-enabled soft robotic sleeve to enable lymphedema treatment is presented. Compression sleeves represent the current, suboptimal standard of care, and stationary pumps assist with lymph drainage; however, effective systems that are truly wearable while performing daily activities are very scarce. This problematic trade-off between performance and wearability requires a new solution, which is addressed by an innovative microfluidic device. Its novelty lies in the use of light, small, and inexpensive air microfluidic chips (35 × 20 × 5 mm3 in size) t

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Delgado, P., O. Oshinowo, M. E. Fay, et al. "Universal pre-mixing dry-film stickers capable of retrofitting existing microfluidics." Biomicrofluidics 17, no. 1 (2023): 014104. http://dx.doi.org/10.1063/5.0122771.

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Integrating microfluidic mixers into lab-on-a-chip devices remains challenging yet important for numerous applications including dilutions, extractions, addition of reagents or drugs, and particle synthesis. High-efficiency mixers utilize large or intricate geometries that are difficult to manufacture and co-implement with lab-on-a-chip processes, leading to cumbersome two-chip solutions. We present a universal dry-film microfluidic mixing sticker that can retrofit pre-existing microfluidics and maintain high mixing performance over a range of Reynolds numbers and input mixing ratios. To attac

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Dr., Pragya. "Applications of Microfluidics in Biomedical and Pharmaceutical Fields -An Overview." International Journal of Preventive Medicine and Health (IJPMH) 5, no. 4 (2025): 5–10. https://doi.org/10.54105/ijpmh.D1066.05040525.

Texto completo da fonte

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<strong>Abstract: </strong>The precise manipulation of fluids at the microscale level within minuscule channels measuring tens to hundreds of micrometres is the subject of the multifaceted field of microfluidics. This technology has transformed the pharmaceutical industry by enabling miniaturized, highthroughput, and economical solutions for drug discovery, formulation, and delivery. The creation of sophisticated drug delivery systems like nanoparticles and liposomes has become far simpler due to this method that can precisely control fluid dynamics, which also enables faster reaction kinetics

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Shi, Jingyu, Yu Zhang, and Mo Yang. "Recent development of microfluidics-based platforms for respiratory virus detection." Biomicrofluidics 17, no. 2 (2023): 024104. http://dx.doi.org/10.1063/5.0135778.

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With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive assays are needed to expedite diagnosis and early intervention. Conventional methods for detection of respiratory viruses include cell culture-based assays, serological tests, nucleic acid detection (e.g., RT-PCR), and direct immunoassays. However, these traditional methods are often time-consuming, labor-intensive, and require laboratory facilities, which cannot meet the testing needs, especially during pandemics of res

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