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Artigos de revistas sobre o tema "Mucosal dysplasia"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Ikebata, Akiyoshi, Masayuki Shimoda, Koji Okabayashi, et al. "Demarcated redness associated with increased vascular density/size: a useful marker of flat-type dysplasia in patients with ulcerative colitis." Endoscopy International Open 09, no. 04 (2021): E552—E561. http://dx.doi.org/10.1055/a-1352-2709.

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Abstract Background and study aims Recent advances in endoscopic equipment and diagnostic techniques have improved the detection of dysplasia in the inflamed mucosa of patients with ulcerative colitis (UC). However, it remains difficult to endoscopically identify flat-type dysplasia which has been formerly recognized as invisible dysplasia. Patients and methods In this retrospective, single-center study, we endoscopically identified 10 cases of flat-type-predominant dysplasia by targeted biopsy among 38 intramucosal dysplasia lesions from patients with UC who underwent surgical or endoscopic r

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Appelman, Henry D. "Adenocarcinoma in Barrett Mucosa Treated by Endoscopic Mucosal Resection." Archives of Pathology & Laboratory Medicine 133, no. 11 (2009): 1793–97. http://dx.doi.org/10.5858/133.11.1793.

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Abstract Adenocarcinoma and dysplasias are recognized complications of Barrett mucosa. In the past, the treatment for this carcinoma was esophagectomy. However, new techniques, including endoscopic mucosal resection, sometimes replace esophagectomy and are becoming standard procedures in clinical practice, not just in major medical centers. Pathologists must learn to handle these specimens, which have extensive artifacts. Also, Barrett mucosa has duplicated stromal layers beneath the mucosa that include a new lamina propria and a new muscularis mucosae. We must be aware of these peculiarities

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RUBIO, C. A., and R. H. RIDDELL. "Mucosal cysts in Barrett's mucosa with dysplasia." APMIS 97, no. 1-6 (1989): 297–301. http://dx.doi.org/10.1111/j.1699-0463.1989.tb00791.x.

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Maione, Francesco, Alessia Chini, Rosa Maione, et al. "Endoscopic Diagnosis and Management of Barrett’s Esophagus with Low-Grade Dysplasia." Diagnostics 12, no. 5 (2022): 1295. http://dx.doi.org/10.3390/diagnostics12051295.

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Barrett’s Esophagus is a common condition associated with chronic gastroesophageal reflux disease. It is well known that it has an association with a higher incidence of esophageal adenocarcinoma, but this neoplastic transformation is first preceded by the onset of low and high-grade dysplasia. The evaluation of low grade dysplastic esophageal mucosa is still controversial; although endoscopic surveillance is preferred, several minimally invasive endoscopic therapeutic approaches are available. Endoscopic mucosal resection and radiofrequency ablation are the most used endoscopic treatments for

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5

Sarigol, Samra, Robert Wyllie, Terry Gramlich, et al. "Incidence of Dysplasia in Pelvic Pouches in Pediatric Patients After Ileal Pouch‐Anal Anastomosis for Ulcerative Colitis." Journal of Pediatric Gastroenterology and Nutrition 28, no. 4 (1999): 429–34. http://dx.doi.org/10.1002/j.1536-4801.1999.tb02105.x.

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ABSTRACTBackground:The purpose of this study was to evaluate the incidence of dysplasia and the mucosal adaptation patterns of pelvic pouches in children and adolescents who had undergone ileal pouch‐anal anastomosis for ulcerative colitis.Methods:Between 1982 and 1996, 176 pediatric patients with ulcerative colitis underwent ilial pouch‐anal anastomosis. Seventy‐six patients were followed up after surgery at the Cleveland Clinic. Pouch biopsy specimens were reviewed for dysplasia and to determine mucosal adaptation patterns. Fifty‐eight of the 76 patients had an average of three mucosal biops

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6

Elsadek, Hany M., and Mamdouh M. Radwan. "Diagnostic Accuracy of Mucosal Biopsy versus Endoscopic Mucosal Resection in Barrett’s Esophagus and Related Superficial Lesions." International Scholarly Research Notices 2015 (January 29, 2015): 1–6. http://dx.doi.org/10.1155/2015/735807.

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Background. Endoscopic surveillance for early detection of dysplastic or neoplastic changes in patients with Barrett's esophagus (BE) depends usually on biopsy. The diagnostic and therapeutic role of endoscopic mucosal resection (EMR) in BE is rapidly growing. Objective. The aim of this study was to check the accuracy of biopsy for precise histopathologic diagnosis of dysplasia and neoplasia, compared to EMR in patients having BE and related superficial esophageal lesions. Methods. A total of 48 patients with previously diagnosed BE (36 men, 12 women, mean age 49.75±13.3 years) underwent routi

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7

Wayne, Sigrid, and Robert A. Robinson. "Upper Aerodigestive Tract Squamous Dysplasia: Correlation With p16, p53, pRb, and Ki-67 Expression." Archives of Pathology & Laboratory Medicine 130, no. 9 (2006): 1309–14. http://dx.doi.org/10.5858/2006-130-1309-uatsdc.

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Abstract Context.—Differential expression of cell cycle–associated proteins may correlate with human papillomavirus status and may help delineate degree of dysplasia in upper aerodigestive tract squamous lesions. Objective.—To determine intraepithelial height of immunohistochemical staining for p16, p53, pRb, and Ki-67 in upper aerodigestive tract lesions with reference to degree of dysplasia. Human papillomavirus status was ascertained to correlate with p16 expression. Design.—Biopsy specimens of 53 squamous dysplastic and 13 keratotic/hyperplastic lesions were immunohistochemically stained f

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Lahav, Yonatan, James A. Burns, Steven Feinberg, James T. Heaton, and Steven M. Zeitels. "Initial Anatomic Geographic Presentation of Glottal Dysplasia." Annals of Otology, Rhinology & Laryngology 118, no. 5 (2009): 321–25. http://dx.doi.org/10.1177/000348940911800501.

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Glottal dysplasia is likely the most common laryngeal disease with a discernible lesion; however, investigations describing its initial anatomic geographic presentation are rare. To examine this, we identified 52 patients who did not have significant prior treatment or glottal cancer. Thirty-one patients had bilateral disease, so there were 83 vocal folds with precancerous dysplasia. The phonatory mucosa was the dominant disease site in all; the epicenter was on the superior surface in 65 of the 83 folds and on the medial surface in 18 of the 83 folds. The arytenoid mucosa was involved in 8 of

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9

Lim, Liang, Catherine Streutker, Norman Marcon, et al. "A feasibility study of photoacoustic imaging of ex vivo endoscopic mucosal resection tissues from Barrett’s esophagus patients." Endoscopy International Open 05, no. 08 (2017): E775—E783. http://dx.doi.org/10.1055/s-0043-111790.

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Abstract Background and study aims Accurate endoscopic detection of dysplasia in patients with Barrett’s esophagus (BE) remains a major clinical challenge. The current standard is to take multiple biopsies under endoscopic image guidance, but this leaves the majority of the tissue unsampled, leading to significant risk of missing dysplasia. Furthermore, determining whether there is submucosal invasion is essential for proper staging. Hence, there is a clinical need for a rapid in vivo wide-field imaging method to identify dysplasia in BE, with the capability of imaging beyond the mucosal layer

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10

McCaul, James Anthony, Jeremy McMahon McMahon, Jacqueline Quantrill, et al. "LIHNCS: Lugol’s Iodine in Head and Neck Cancer Surgery—A multi-centre, randomised, controlled trial assessing the effectiveness of Lugol’s Iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in-situ at mucosal resection margin of oral and oropharyngeal squamous cell carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6065. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6065.

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6065 Background: Oral cavity and oropharynx cancer are increasing worldwide but survival has not significantly improved over the last thirty years. Presence of dysplasia or carcinoma in-situ at surgical margins following resection of squamous carcinoma (SCC) of the head and neck is associated with increased local recurrence and reduced survival. While carcinoma can usually be distinguished from normal mucosa, dysplasia is less readily distinguished at operation. We describe outcomes of LIHNCS, a RCT assessing effectiveness of Lugol’s iodine staining for visualization and excision of margin dys

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Vukomanovic-Djurdjevic, Biserka, Gordana Basta-Jovanovic, N. Baletic, Milica Berisavac, D. Nenadic, and A. Peric. "Significance of survivin immunoreactivity and morphometric analysis of HPV-induced cervical dysplasia." Archives of Biological Sciences 66, no. 1 (2014): 429–36. http://dx.doi.org/10.2298/abs1401429v.

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Genomic integration of high-risk human papilloma virus in the nucleus of cervical epithelial mucosal cells leads to epithelial dysplasia. The aim of this study was to determine the relevance of correlation between epithelial survivin expression and the degree of human papilloma virus (HPV)-induced cervical epithelial dysplasia, and to establish the significance of morphometric analysis of the nuclear area in the assessment of the degree of cervical dysplasia. This retrospective study included 99 women with primary, previously untreated lesions, and colposcopic findings indicating dysplasia, in

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12

Safira, Fathi Rahmah, and Sugiarto Sugiarto. "Histopathological Features of the Gastric Mucosa in Patients with Chronic Gastritis and Helicobacter pylori Infection at Pertamina Central Hospital Jakarta." Muhammadiyah Medical Journal 2, no. 2 (2021): 70. http://dx.doi.org/10.24853/mmj.2.2.70-74.

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Background: Chronic gastritis is a chronic inflammation of the gastric mucosa, accompanied by changes in mucosal histology with or without Helicobacter pylori infection. Changes in the gastric mucosa include gastric mucosal atrophy, intestinal metaplasia, and epithelial dysplasia. Purposes: This study aims to determine the microscopic appearance of the mucosa in chronic gastritis patients based on standard histopathological criteria, which include gland atrophy, intestinal metaplasia, dysplasia with or without Helicobacter pylori infection at Pertamina Central Hospital Jakarta period 2018 - 20

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13

Overholt, Bergein F. "Results of Photodynamic Therapy in Barrett’s Esophagus: A Review." Canadian Journal of Gastroenterology 13, no. 5 (1999): 393–96. http://dx.doi.org/10.1155/1999/692453.

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Barrett’s esophagus is associated with an increased occurrence of mucosal dysplasia and adenocarcinoma in the specialized glandular mucosa, with a 30- to 52-fold increase in the occurrence of esophageal cancer compared with the normal population. An alternative to esophagectomy as a treatment modality is needed because of the high morbidity and mortality associated with it. Photodynamic therapy offers an alternative nonsurgical therapy that eliminates dysplasia and superficial cancer, and reduces Barrett’s mucosa while reducing the risks and costs compared with those of esophagectomy. The use

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14

Kharchenko, O., and N. Kharchenko. "ANALYSIS OF THE MITOTIC REGIME OF THE MUCOSA IN PATIENTS WITH CHRONIC STOMACH DISEASES." BIOLOGY & ECOLOGY 7, no. 2 (2022): 115–19. http://dx.doi.org/10.33989/2021.7.2.261559.

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Chronic atrophic gastritis, chronic duodenal and gastric ulcers create conditions for the formation of precancerous changes in the gastric mucosa in the form of dysplasia. The biopsy material of the gastric mucosa from patients with chronic atrophic gastritis, chronic gastric and duodenal ulcers - 75 was studied. The development of severe dysplasia of the epithelium of the gastric mucosa was observed mainly in more severe forms of chronic gastritis. High proliferative activity of the epithelium of the gastric mucosa was confirmed by the expression of the marker Ki-67 with a label index (MI)&gt

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Samatha, Yalamanchili, Avula Jogendra Sai Sankar, KS Ganapathy, Kandula Srinivas, Dasari Ankineedu, and Alluri Leela Subhashini Choudary. "Clinicopathologic Evaluation of Lesions associated with Tobacco Usage." Journal of Contemporary Dental Practice 15, no. 4 (2014): 466–72. http://dx.doi.org/10.5005/jp-journals-10024-1564.

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ABSTRACT Introduction Tobacco usage in different forms is the single most common etiological factor responsible for oral cancers. The aim of the present study was to record various mucosal lesions associated with tobacco usage and to ascertain the prevalence of dysplasia in them by histopathological evaluation and to compare the extent of dysplastic features seen among patients associated with a habit of smoked and smokeless form of tobacco. Materials and methods Seventy-six patients with the clinical diagnosis of tobacco related lesions (Leukoplakia, Erythroplakia, Nicotina stomatitis, Tobacc

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Simonova, O. V., L. M. Mosiychuk, and O. P. Petishko. "Xanthomas and precancerous changes of the stomach: an accidental combination or an important prognostic endoscopic marker?" GASTROENTEROLOGY 57, no. 1 (2023): 1–10. http://dx.doi.org/10.22141/2308-2097.57.1.2023.522.

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Background. The article deals with the study of gastric xanthomas, benign accidental formations with an unknown etiopathogenesis, which, according to the literature, are associated with a number of pathological conditions (atrophic gastritis, intestinal metaplasia, dysplasia, gastric cancer, dyslipidemia, etc.). The purpose was to study the prevalence of gastric xanthomas in patients with atrophic gastritis and to analyze their relationship with endoscopic changes in the stomach, including precancerous conditions. Materials and methods. Esophagogastroduodenoscopy was performed using the EVIS E

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17

Jain, Deepanshu, Sanna Fatima, Shilpa Jain, and Shashideep Singhal. "Volumetric Laser Endomicroscopy for Barrett’s Esophagus – Looking at the Fine Print." Journal of Gastrointestinal and Liver Diseases 26, no. 3 (2017): 291–97. http://dx.doi.org/10.15403/jgld.2014.1121.263.jai.

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Barrett’s esophagus (BE) is a premalignant condition. The incidence of adenocarcinoma in BE has been reported to be between 0.1-3%. Dysplasia in BE is patchy and extensive biopsy sampling is labor intensive, low yield and does not eliminate the sampling error completely. Volumetric laser endomicroscopy (VLE) is expected to enable endoscopists to do targeted biopsy of dysplastic/cancerous lesions (not visible on white light endoscopy) among patients with BE. We reviewed 7 studies with a total of 62 subjects who had undergone VLE. Of 34 patients with available data, VLE correlated with histology

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Mosyichuk, L. M., O. M. Tatarchuk, O. V. Simonova, and O. P. Petishko. "Features of cytokine balance with the progression of structural changes in the gastric mucosa in patients with atrophic gastritis." GASTROENTEROLOGY 55, no. 2 (2021): 67–73. http://dx.doi.org/10.22141/2308-2097.55.2.2021.233625.

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Background. Until now, the issue of the correlation between the cytokine balance and the progression of structural changes in the gastric mucosa remain completely uncertain. At the same time, the determination of the role of cytokine balance as a component of gastric carcinogenesis will make it possible to substantiate new approaches to managing patients with atrophic gastritis. The purpose was to assess the level of pro- and anti-inflammatory cytokines, vascular endothelial growth factor (VEGF) at the stages of progression of structural changes in the gastric mucosa of patients with atrophic

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19

Alekseeva, O. P., and E. N. Kolodey. "Technology of liquid chromatographic serum spectral images fixation in the diagnosis of colonic mucosal dysplasia." Kazan medical journal 98, no. 2 (2017): 272–77. http://dx.doi.org/10.17750/kmj2017-272.

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Aim. To demonstrate the possibility of use of technology of liquid chromatographic serum spectral images fixing for the diagnosis of colonic epithelial dysplasia in patients with ulcerative colitis.  Methods. 49 patients with ulcerative colitis were examined. Colonoscopy with Mayo index evaluation and biopsy of the intestinal mucosa were carried out using OLYMPUS CV-170 device (Japan). Biopsies were taken from the most affected areas of the colonic mucosa (from 3 to 10 biopsies). Morphological study included an assessment of histological activity of ulcerative colitis and colonic mucosal

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Rzepakowska, Anna, Ewelina Sielska-Badurek, Ewa Osuch-Wójcikiewicz, Michał Sobol, and Kazimierz Niemczyk. "The predictive value of videostroboscopy in the assessment of premalignant lesions and early glottis cancers." Otolaryngologia Polska 71, no. 4 (2017): 14–18. http://dx.doi.org/10.5604/01.3001.0010.2243.

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Objective: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds. Material and methods: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery. The LVS study included: localization of the leasion, movement of the vocal folds, mucosal wave

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Oh, Jung Hwan, Sung Hoon Jung, DaeYoung Cheung, Mun Gan Rhyu, and Seung Jin Hong. "Association of extensive delayed overmethylation influenced by advanced atrophy with risk for gastric cancer." Journal of Clinical Oncology 33, no. 3_suppl (2015): 13. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.13.

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13 Background: Helicobacter pylori (HP) infection facilitates overmethylation of CpG-island genes, which can be delayed by advanced mucosal atrophy. Delayed overmethylation results in unstable cell phenotypes responsible for gastric cancer. To delineate cancer risk period, the overmethylation period from HP infection to severe atrophy was traced in the gastric cancer and dysplasia. Methods: A pair of normal-appearing mucosal specimens was obtained from the antrum and body of 110 HP-positive and 95 HP-negative controls, 99 cancer patients, and 118 dysplasia patients. Gastric mucosal atrophy was

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Nishiwaki, Ryo, Yasuhiro Inoue, Masataka Sugao, et al. "Hangeshashinto-Associated Mesenteric Phlebosclerosis and Highly Atypical Adenoma Requiring Laparoscopic Right Hemicolectomy." Diagnostics 14, no. 5 (2024): 565. http://dx.doi.org/10.3390/diagnostics14050565.

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Mesenteric phlebosclerosis is a rare ischemic colonic disorder caused by impaired venous drainage. Its prevalence is higher in East Asia, where herbal medicine is widely used. Treatment remains controversial. A 76-year-old woman who had taken Hangeshashinto, an herbal medicine, for 11 years was admitted for endoscopic treatment of high-grade dysplasia in the ascending colon. She had diarrhea and mesenteric phlebosclerosis diagnosed by abdominal computed tomography at age 71. At age 75, small polyps were detected in the ascending colon. A subsequent study revealed an increase in polyp size to 1

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Ahsen, Osman, Kaicheng Liang, Hsiang-Chieh Lee, et al. "Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography." Endoscopy 51, no. 04 (2018): 355–59. http://dx.doi.org/10.1055/a-0725-7995.

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Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subs

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Korelitz, B. I., G. Y. Lauwers, and S. C. Sommers. "Rectal mucosal dysplasia in Crohn's disease." Gut 31, no. 12 (1990): 1382–86. http://dx.doi.org/10.1136/gut.31.12.1382.

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Dhaliwal, Lovekirat, and Prasad G. Iyer. "State of the Art: Management of Barrett’s Esophagus Related Dysplasia and Neoplasia—Which Patient and What Therapy?" Foregut: The Journal of the American Foregut Society 1, no. 1 (2021): 68–77. http://dx.doi.org/10.1177/2634516121993260.

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Endoscopic eradication therapy (EET) is safe and effective in the management of Barrett’s esophagus (BE) related dysplasia and early adenocarcinoma. EET includes endoscopic resection of the visible lesions followed by ablation to eradicate the residual Barrett’s epithelium. Techniques available for endoscopic resection include cap-based endoscopic mucosal resection and endoscopic submucosal dissection. Ablative therapies such as RFA, cryoablation and APC are used for the eradication of dysplastic BE and to prevent progression to EAC. Complete remission of intestinal metaplasia is the goal of E

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Sasaki, Takamitsu, Rina Fujiwara-Tani, Yi Luo, et al. "Effects of High-Mobility Group Box-1 on Mucosal Immunity and Epithelial Differentiation in Colitic Carcinoma." International Journal of Molecular Sciences 25, no. 13 (2024): 6846. http://dx.doi.org/10.3390/ijms25136846.

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Abnormalities in mucosal immunity are involved in the onset and progression of ulcerative colitis (UC), resulting in a high incidence of colorectal cancer (CRC). While high-mobility group box-1 (HMGB1) is overexpressed during colorectal carcinogenesis, its role in UC-related carcinogenesis remains unclear. In the present study, we investigated the role of HMGB1 in UC-related carcinogenesis and sporadic CRC. Both the azoxymethane colon carcinogenesis and dextran sulfate sodium colitis carcinogenesis models demonstrated temporal increases in mucosal HMGB1 levels. Activated CD8+ cells initially i

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Kim, Byung-Wook, Younghee Choe, Joon Sung Kim, and Soo-Young Na. "Dysbiosis in gastric mucosal microbiota associated with gastric carcinogenesis." Journal of Clinical Oncology 42, no. 3_suppl (2024): 381. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.381.

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381 Background: Gastric microbiota, including H. pylori, may play a role in the development of gastric cancer. This study aimed to investigate the gastric microbiota throughout the stages of gastric carcinogenesis, encompassing atrophic gastritis, gastric dysplasia, and gastric adenocarcinoma. Methods: From December 2021 to August 2023, we collected gastric mucosal tissue samples from patients with atrophic gastritis, gastric dysplasia, and early gastric cancer. Subsequently, we conducted 16S rRNA gene profiling through next-generation sequencing. We compared alpha-diversity and beta-diversity

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Brahmania, Mayur, Eric Lam, Jennifer Telford, and Robert Enns. "Endoscopic Mucosal Resection: Early Experience in British Columbia." Canadian Journal of Gastroenterology 24, no. 4 (2010): 239–44. http://dx.doi.org/10.1155/2010/897473.

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BACKGROUND: Endoscopic mucosal resection (EMR) has been proposed as a primary method of managing patients with dysplasia- or mucosal-based cancers of the esophagus.OBJECTIVES: To evaluate the use of EMR for the treatment of Barrett’s esophagus with dysplasia or early adenocarcinoma, assessing efficacy, complication rates and long-term outcomes.METHODS: All patients who underwent EMR at St Paul’s Hospital (Vancouver, British Columbia) were reviewed. Eligible patients were assessed with aggressive biopsy protocols. Detected cancers were staged with both endoscopic ultrasound imaging and computed

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Karpuk, N. A., S. P. Rubnikovich, I. V. Zhyltsov, O. Ch Mazur, I. Yu Karpuk, and A. P. Mikhalenka. "Clinical Significance of Pathogenicity of Somatic Mutations in Oral Leukoplakia: a Prospective Observational Study." Kuban Scientific Medical Bulletin 30, no. 4 (2023): 37–47. http://dx.doi.org/10.25207/1608-6228-2023-30-4-37-47.

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Background. The vast majority of malignant neoplasms of the oral mucosa refer to squamous cell carcinomas. The development of squamous cell carcinoma of the oral mucosa is often promoted by previous potentially malignant diseases, with oral leukoplakia dominating among them.Objective. To determine the clinical significance of the pathogenicity of somatic mutations in oral mucosal leukoplakia.Methods. The study material included 24 samples of abnormal epithelium of the oral mucosa from leukoplakia patients. QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used for deoxyribonucleic acid (DNA) ex

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Tsoi, Edward H., Sasha Fehily, Richard Williams, Paul Desmond, and Andrew Taylor. "Diffuse endoscopically visible, predominantly low grade dysplasia in Barrett’s esophagus (with video)." Endoscopy International Open 07, no. 12 (2019): E1742—E1747. http://dx.doi.org/10.1055/a-1031-9327.

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Abstract Background Low grade dysplasia (LGD) in Barrett’s esophagus (BE) has generally been considered as undetectable endoscopically. Aim To describe a phenotype which consists of diffuse, endoscopically visible, predominantly low grade dysplasia in Barrett’s esophagus (DEVLB), with often subtle but visible endoscopic changes seen with high definition white light (HDWL) and narrow-band imaging (NBI). Method A systematic search of a prospectively collected database for patients satisfying predefined criteria for DEVLB and a review of endoscopic and histological features of biopsies and endosc

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Ştefănescu, Daniela, S. P. Pereira, M. M. Filip, A. Săftoiu, and S. Cazacu. "Advanced Endoscopic Imaging Techniques for the Study of Colonic Mucosa in Patients with Inflammatory Bowel Disease." Romanian Journal Of Internal Medicine 54, no. 1 (2016): 11–23. http://dx.doi.org/10.1515/rjim-2015-0050.

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Background. Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD) associated with colorectal cancer risk in long-standing diseases. In order to assess the colonic mucosa and to discover dysplastic or neoplastic lesions, advanced endoscopic techniques are needed. Such techniques are detailed in this review: chromoendoscopy, autofluorescence imaging (AFI), narrow band imaging (NBI), i-SCAN, Fujinon Intelligent Color Enhancement (FICE) and confocal laser endomicroscopy (CLE). Aim. The aim of the review is to describe and establish the clinical impact of advanced endoscopic

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Rianto, Bambang Udji Djoko, Linggawati Kurniawan, and Kartono Sudarman. "The difference of nasal mucosal cytology features in gas station workers compared to non-gas station workers." Journal of the Medical Sciences (Berkala Ilmu Kedokteran) 51, no. 1 (2019): 63. http://dx.doi.org/10.19106/jmedsci005101201908.

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The pollutants contained in an outdoor air environment for example gasoline vapors can cause epithelial inflammation, metaplasia, and dysplasia. This study aimed to determine the difference in cytological nasal mucosa between gas station workers and non-gas station workers. This research used a cross-sectional design. There were 80 samples with inclusion criteria: aged 20-50 years, worked more than 3 months, consisting of 40 gas station workers (exposed group) and 40 non-gas station workers (unexposed group) who did not use nasal drops in the last ten days. The exclusion criteria of both group

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Ivina, A. A., Yu O. Tigay, O. F. Rabinovich, V. A. Goryachev, D. R. Familia Frias, and I. I. Babichenko. "Molecular genetic criteria for oral mucosal epithelial malignization." CLINICAL AND EXPERIMENTAL MORPHOLOGY 12, no. 4 (2023): 23–31. http://dx.doi.org/10.31088/cem2023.12.4.23-31.

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Introduction. When examining the oral mucosa (OM) in the presence of an inflammatory process, the initial signs of malignancy are not always visible. Amid an inflammatory infiltrate, benign changes such as epithelial hyperplasia (EH), epithelial dysplasia (ED) of varying severity, and squamous cell carcinoma (SCC) can be hidden. The aim of the paper was to study the proliferative activity of epithelial cells of the OM, TERT expression, and amplification of telomerase TERC gene in the development of epithelial hyperplasia, dysplasia, and SCC. Materials and methods. We divided 60 patients into f

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Li, Qiu-yue, Peng-hui Yang, Xin Huang, et al. "Gastric Mucosa Pathology in Rats with Precancerous Lesions of Gastric Cancer with Spleen Deficiency and Blood Stasis." Evidence-Based Complementary and Alternative Medicine 2022 (September 24, 2022): 1–11. http://dx.doi.org/10.1155/2022/1366597.

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Objective. This research aimed at better understanding the histopathological development of precancerous lesions of gastric cancer (PLGC) and organelle ultrastructure changes. Methods. Sprague-Dawley rats were randomly assigned to the model and control groups. Model rats drank N-methyl-N′-nitro-N-nitrosoguanidine solution, while control rats drank pure water ad libitum. At 1, 3, 5, 6, and 8 months after the start of feeding, eight rats were randomly chosen from each group, and gastric mucosa tissues were removed for histopathological analysis. H&E staining was applied to analyze the pathol

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Freeman, Hugh J. "Dysplasia Risk in Ileal Pouches after Reconstructive Surgery for Ulcerative Colitis." Canadian Journal of Gastroenterology 15, no. 11 (2001): 774–75. http://dx.doi.org/10.1155/2001/713823.

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An important goal for the surgeon after performing proctocolectomy for ulcerative colitis is the preservation of continence, with the formation of a pelvic ileal pouch. In most patients who have required this procedure, clinical results have been satisfactory. In recent years, it has become appreciated that many patients with a satisfactory surgical result are still at risk for pouchitis and pouch neoplasia. This is not surprising because creation of a pouch leads to an environment characterized by stasis, with associated mucosal adaptive changes. In some patients, the ileal mucosa in the pouc

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Costa-Navarro, David, Israel Oliver-García, Francisco Javier Lacueva-Gómez, et al. "Chromoendoscopic mucosal resection of a gastric dysplasia." Clinical and Translational Oncology 7, no. 1 (2005): 31–33. http://dx.doi.org/10.1007/bf02710024.

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Boeriu, Alina, Olga Brusnic, Danusia Onișor, Ofelia Pascarenco, C. Boeriu, and Daniela Dobru. "The usefulness of white light endoscopy, narrow band imaging, and magnification for the optimization of diagnosis in Barrett’s esophagus." Acta Medica Marisiensis 60, no. 6 (2014): 244–48. http://dx.doi.org/10.1515/amma-2015-0002.

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Abstract The diagnosis of dysplasia and early neoplasia in Barrett’s esophagus by conventional endoscopy is based on a four- quadrant random biopsies protocol that is prone to sampling errors. Novel endoscopic techniques have been developed to enhance the detection of premalignant and malignant lesions by real time assessment of microvasculare architecture and mucosal structure. Chromoendoscopy with magnification has improved the visualization of lesions, but the dye application impairs a clear evaluation of vascular network. Narrow band imaging endoscopy enhances vascular imaging by using nar

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Sano, Tomoya, Kiyokazu Ozaki, Yui Terayama, Yasushi Kodama, and Tetsuro Matsuura. "A Novel Diabetic Murine Model ofCandida albicans-Induced Mucosal Inflammation and Proliferation." Journal of Diabetes Research 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/509325.

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Chronic hyperplastic candidiasis (CHC) lesions will progress to dysplasia with some of these developing squamous cell carcinoma (SCC). It is well known that diabetic patients are predisposed to candidiasis. Previously, we found that alloxan-induced diabetic rats spontaneously have mucosal hyperplasia withC. albicansinfection and that those lesions progress to SCC. Here, we developed a rat model of candidiasis with diabetes progressing to mucosal proliferation. Diabetes was induced in thirty rats by single intravenous administration of alloxan. Ten nondiabetic rats and fifteen diabetic rats the

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Kim, Han-Na, Min-Jeong Kim, Jonathan P. Jacobs, and Hyo-Joon Yang. "Gastric Microbiota Associated with Gastric Precancerous Lesions in Helicobacter pylori-Negative Patients." Microorganisms 13, no. 1 (2025): 81. https://doi.org/10.3390/microorganisms13010081.

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Studies on the gastric microbiota associated with gastric precancerous lesions remain limited. This study aimed to profile the gastric mucosal microbiota in patients with Helicobacter pylori-negative precancerous lesions. Gastric mucosal samples were obtained from 67 H. pylori-negative patients, including those with chronic gastritis (CG), intestinal metaplasia (IM), and dysplasia. The V3–V4 region of the 16S rRNA gene was sequenced and analyzed. No significant difference was observed in the alpha or beta diversity of the gastric microbiota among the groups. However, a taxonomic analysis revea

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Chiang, Tien-En, Yu-Chun Lin, Chi-Tsung Wu, Cheng-Yu Yang, Sheng-Tang Wu, and Yuan-Wu Chen. "Comparison of the accuracy of diagnoses of oral potentially malignant disorders with dysplasia by a general dental clinician and a specialist using the Taiwanese Nationwide Oral Mucosal Screening Program." PLOS ONE 16, no. 1 (2021): e0244740. http://dx.doi.org/10.1371/journal.pone.0244740.

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Screening for oral potentially malignant disorders (OPMDs) with dysplasia in high-risk groups is suggested in countries with a high prevalence of the disorders. This study aimed to compare the accuracy of diagnoses of OPMDs with dysplasia made by a primary examiner (general dental clinician) and a specialist (oral and maxillofacial surgeon) using the current Taiwanese Nationwide Oral Mucosal Screening Program (TNOMSP). A total of 134 high-risk participants were enrolled for oral mucosal screening via the TNOMSP. A primary examiner and a specialist examined each participant. Mucosal biopsies we

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Dunn, Janet A., Raghav Kulkarni, David Gouldesbrough, et al. "LIHNCS trial: Lugol's iodine in head and neck cancer surgery." Journal of Clinical Oncology 30, no. 15_suppl (2012): e16042-e16042. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16042.

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e16042 Background: Residual dysplasia at margins of mucosal tumour resection is a cause of disease failure. While risk of transformation of dysplasia is difficult to assess, malignant cells within a field of dysplastic change indicate high transformation potential of this dysplastic field. Lugol's iodine assists in the assessment of surgical margins at tumour resection to ensure removal of margin dysplasia where present and resectable using the surrogate biomarker of glycogen storage. This multicenter RCT assesses efficacy of this technique in head and neck cancer surgery and is recruiting ove

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RUBIO, CARLOS A., MICHAEL VIETH, and CORINNA LANG-SCHWARZ. "Dysplastic Crypts in Asymmetric Branching in Ulcerative Colitis: A Preliminary Report." Cancer Diagnosis & Prognosis 2, no. 3 (2022): 305–7. http://dx.doi.org/10.21873/cdp.10109.

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Aim: To report the detection of dysplastic crypts in asymmetric branching (DCAB) in biopsies from patients with ulcerative colitis (UC). Patients and Methods: One hundred consecutive endoscopic biopsies from patients with UC undergoing surveillance were reviewed. Results: Three biopsy/cases showed DCAB. The frequency of DCAB varied from two in one case, three in another case, and five in the remaining case. Conclusion: The final outcome of DCAB is to generate two or more dysplastic asymmetric offspring-crypts. Repeated DCAB offspring formation, together with new DCAB, would boost the pool of d

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Odze, Robert D. "Update on the Diagnosis and Treatment of Barrett Esophagus and Related Neoplastic Precursor Lesions." Archives of Pathology & Laboratory Medicine 132, no. 10 (2008): 1577–85. http://dx.doi.org/10.5858/2008-132-1577-uotdat.

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Abstract Context.—At present, Barrett esophagus is the most common cause of esophageal adenocarcinoma. In the past 20 years, the incidence of esophageal adenocarcinoma in white males has exceeded that of tumors of the colorectum, lung, prostate, and skin. Objectives.—To (1) provide an evidence-based review of the diagnosis, classification, and histologic differentiation of Barrett esophagus from gastric carditis, (2) provide a summary of the key pathologic features of precursor lesions, such as dysplasia, and (3) evaluate adjunctive markers of dysplasia and predictive markers for the developme

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Luigiano, Carmelo, Giuseppe Iabichino, Leonardo Henry Eusebi, et al. "Outcomes of Radiofrequency Ablation for Dysplastic Barrett’s Esophagus: A Comprehensive Review." Gastroenterology Research and Practice 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/4249510.

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Barrett’s esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett’s esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ablative techniques have been developed with the goal of eradicating Barrett’s esophagus and preventing neoplastic progression to esophageal adenocarcinoma. For patients with high-grade dysplasia or intr

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Schweinfurth, John M., Eric Powitzky, and Robert H. Ossoff. "Regression of Laryngeal Dysplasia after Serial Microflap Excision." Annals of Otology, Rhinology & Laryngology 110, no. 9 (2001): 811–14. http://dx.doi.org/10.1177/000348940111000902.

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There is no consensus on the ideal management of premalignant lesions of the larynx. Published reports describe the use of mucosal stripping, microsurgical techniques, CO2 laser excision and ablation, and even conservation laryngeal surgery and radiotherapy. We performed a retrospective evaluation of 43 men and 11 women who underwent serial excision of dysplastic lesions with the microflap technique between 1990 and 2001. The average age of the patients was 57.2 years; 64% had a history of cigarette smoking, and 46% a history of alcohol consumption. The lesions were located on the middle part

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Fedorov, E. D., A. V. Shidii-Zakrua, L. M. Mikhaleva, et al. "Diagnosis of Columnar Metaplasia of the Esophageal Mucosa in Patients with Complicated Gastroesophageal Reflux Disease." Russian Journal of Gastroenterology, Hepatology, Coloproctology 34, no. 1 (2024): 15–30. http://dx.doi.org/10.22416/1382-4376-2024-34-1-15-30.

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Aim: to improve methods of diagnostics of esophageal mucosal forms of metaplasia and dysplasia in patients with complicated forms of gastroesophageal reflux disease (GERD) using multidisciplinary approach.Material and methods. Overall, 131 patients aged 18 to 84 years (mean age — 55.8 ± 16.7 years) with confirmed diagnosis of GERD complicated by development of metaplasia of mucosa of distal esophagus were included in retroand prospective study. At the prehospital stage the patients' complaints were estimated, anamnesis was taken. At the first stage of the diagnostic program all patients underw

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Jang, Byoung Kuk, Yeong Seok Lee, Seong Yeol Kim, et al. "Diagnostic Value of Endoscopic Mucosal Resection in Low Grade Dysplasia of Gastric Mucosa." Gastrointestinal Endoscopy 63, no. 5 (2006): AB105. http://dx.doi.org/10.1016/j.gie.2006.03.116.

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Neves, André, Massimiliano Di Pietro, Maria O’Donovan, et al. "Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue." Endoscopy 50, no. 06 (2018): 618–25. http://dx.doi.org/10.1055/s-0043-124080.

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Abstract Background and study aims Endoscopic surveillance for Barrett’s esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting. Methods Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited. Freshly collected EMR specimens were sprayed at the bedside with fluorescent lectin and then ima

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Bertani, Helga, Flavia Pigò, Emanuele Dabizzi, et al. "Advances in Endoscopic Visualization of Barrett’s Esophagus: The Role of Confocal Laser Endomicroscopy." Gastroenterology Research and Practice 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/493961.

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Many endoscopic imaging modalities have been developed and introduced into clinical practice to enhance the diagnostic capabilities of upper endoscopy. In the past, detection of dysplasia and carcinoma of esophagus had been dependent on biopsies taken during standard white-light endoscopy (WLE). Recently high-resolution (HR) endoscopy enables us to visualize esophageal mucosa but resolution for glandular structures and cells is still low. Probe-based confocal laser endomicroscopy (pCLE) is a new promising diagnostic technique by which details of glandular and vascular structures of mucosal lay

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De Felice, Claudio, Stefano Parrini, Alessandro Barducci, Giovanna Chitano, Gabriele Tonni, and Giuseppe Latini. "Abnormal oral mucosal light reflectance in bronchopulmonary dysplasia." Early Human Development 82, no. 4 (2006): 273–78. http://dx.doi.org/10.1016/j.earlhumdev.2005.09.013.

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