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Artigos de revistas sobre o tema "Neurotrophic peptide"

Autor: Grafiati

Publicado: 7 de julho de 2024

Última modificação: 31 de julho de 2025

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1

Glazova, N. Yu, D. М. Manchenko, Е. А. Sebentsova, et al. "The effect of ACTH/MSH N-terminal fragment analogs on the anxiety level, pain sensitivity and levels of neurotrophic factors BDNF and VEGF in primary neuronal cultures of rats." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 10 (2024): 1752–66. https://doi.org/10.31857/s0869813924100127.

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ACTH/MSH-like peptides (melanocortins) have a wide range of neurotropic effects, including effects on learning and memory processes, neuroprotection, emotional state and pain sensitivity. Present work is aimed to compare the effects of peptides, the structure of which includes a natural fragment of ACTH and a stabilizing tripeptide PGP. The peptides ACTH4-7PGP (Semax), ACTH6-9PGP и ACTH7-10PGP were used in the work. The effects of these peptides on the exploratory behavior, anxiety level and pain sensitivity of white rats, as well as on the protein levels of the neurotrophic factors BDNF (brai

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Notaras, Michael, and Maarten van den Buuse. "Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation." Neuroscientist 25, no. 5 (2018): 434–54. http://dx.doi.org/10.1177/1073858418810142.

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Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that now spans 35 years of research. While all neurotrophins share considerable overlap in sequence homology and their processing, BDNF has become the most widely studied neurotrophin because of its broad roles in brain homeostasis, health, and disease. Although research on BDNF has produced thousands of articles, there remain numerous long-standing questions on aspects of BDNF molecular biology and signaling. Here we provide a comprehensive review, including both a historical narrative and a forward-looking

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3

Longo, F. M., T. K. Vu, and W. C. Mobley. "The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides." Cell Regulation 1, no. 2 (1990): 189–95. http://dx.doi.org/10.1091/mbc.1.2.189.

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Nerve growth factor (NGF)1 is a neurotrophic polypeptide that acts via specific receptors to promote the survival and growth of neurons. To delineate the NGF domain(s) responsible for eliciting biological activity, we synthesized small peptides corresponding to three regions in NGF that are hydrophilic and highly conserved. Several peptides from mouse NGF region 26-40 inhibited the neurite-promoting effect of NGF on sensory neurons in vitro. Inhibition was sequence-specific and could be overcome by increasing the concentration of NGF. Moreover, peptide actions were specific for NGF-mediated ev

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Wetmore, C. J., Y. Cao, R. F. Pettersson, and L. Olson. "Brain-derived neurotrophic factor (BDNF) peptide antibodies: characterization using a Vaccinia virus expression system." Journal of Histochemistry & Cytochemistry 41, no. 4 (1993): 521–33. http://dx.doi.org/10.1177/41.4.8450192.

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We describe and characterize a series of polyclonal antibodies, generated against amino acid sequences unique to various regions within pro- and mature brain-derived neurotrophic factor (BDNF), a member of the highly conserved nerve growth factor (NGF) family of neurotrophins. Synthetic peptides were coupled to carrier proteins in the presence of glutaraldehyde to restrict the host animals' immune response to epitopes that are compatible with aldehyde fixation. Initial screenings of the reactivity of the antisera were made on brain sections processed for immunohistochemistry after peptide inje

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Redigolo, Luigi, Vanessa Sanfilippo, Diego La Mendola, Giuseppe Forte, and Cristina Satriano. "Bioinspired Nanoplatforms Based on Graphene Oxide and Neurotrophin-Mimicking Peptides." Membranes 13, no. 5 (2023): 489. http://dx.doi.org/10.3390/membranes13050489.

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Neurotrophins (NTs), which are crucial for the functioning of the nervous system, are also known to regulate vascularization. Graphene-based materials may drive neural growth and differentiation, and, thus, have great potential in regenerative medicine. In this work, we scrutinized the nano–biointerface between the cell membrane and hybrids made of neurotrophin-mimicking peptides and graphene oxide (GO) assemblies (pep−GO), to exploit their potential in theranostics (i.e., therapy and imaging/diagnostics) for targeting neurodegenerative diseases (ND) as well as angiogenesis. The pep−GO systems

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6

Baazaoui, Narjes, and Khalid Iqbal. "Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound." Biomolecules 12, no. 10 (2022): 1409. http://dx.doi.org/10.3390/biom12101409.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau and amyloid β pathologies andneuroinflammation. The imbalance of neurotrophic factors with an increase in FGF-2 level and a decrease in brain derived neurotrophic factor (BDNF) and neurotrophin 4 (NT-4) in the hippocampus, frontal cortex and parietal cortex and disruption of the brain micro-environment are other characteristics of AD. Neurotrophi

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Pittenger, Gary, and Aaron Vinik. "Nerve Growth Factor and Diabetic Neuropathy." Experimental Diabesity Research 4, no. 4 (2003): 271–85. http://dx.doi.org/10.1155/edr.2003.271.

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Neuropathy is one of the most debilitating complications of both type 1 and type 2 diabetes, with estimates of prevalence between 50–90% depending on the means of detection. Diabetic neuropathies are heterogeneous and there is variable involvement of large myelinated fibers and small, thinly myelinated fibers. Many of the neuronal abnormalities in diabetes can be duplicated by experimental depletion of specific neurotrophic factors, their receptors or their binding proteins. In experimental models of diabetes there is a reduction in the availability of these growth factors, which may be a cons

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8

Wang, Rong, Jing-Yan Zhang, Fang Yang, Zhi-Juan Ji, Goutam Chakraborty, and Shu-Li Sheng. "A novel neurotrophic peptide: APP63-73." NeuroReport 15, no. 17 (2004): 2677–80. http://dx.doi.org/10.1097/00001756-200412030-00025.

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9

Joliot, A., I. Le Roux, M. Volovitch, E. Bloch-Gallego, and A. Prochiantz. "Neurotrophic activity of a homeobox peptide." Progress in Neurobiology 42, no. 2 (1994): 309–11. http://dx.doi.org/10.1016/0301-0082(94)90070-1.

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Sima, Anders A. F., Weixian Zhang, Zhen-guo Li, and Hideki Kamiya. "The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BB/Wor-rat." Experimental Diabetes Research 2008 (2008): 1–13. http://dx.doi.org/10.1155/2008/230458.

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Diabetic polyneuropathy (DPN) occurs more frequently in type 1 diabetes resulting in a more severe DPN. The differences in DPN between the two types of diabetes are due to differences in the availability of insulin and C-peptide. Insulin and C-peptide provide gene regulatory effects on neurotrophic factors with effects on axonal cytoskeletal proteins and nerve fiber integrity. A significant abnormality in type 1 DPN is nodal degeneration. In the type 1 BB/Wor-rat, C-peptide replacement corrects metabolic abnormalities ameliorating the acute nerve conduction defect. It corrects abnormalities of

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11

Mizui, Toshiyuki, Yasuyuki Ishikawa, Haruko Kumanogoh, et al. "BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met." Proceedings of the National Academy of Sciences 112, no. 23 (2015): E3067—E3074. http://dx.doi.org/10.1073/pnas.1422336112.

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Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood. Here, we investigated the biological role of the pro-peptide of brain-derived neurotrophic factor (BDNF) and first showed that the pro-peptide is expressed and secreted in hippocampal tissues and cultures, respectively. Interestingly, we found that the BDNF pro-peptide directly facilitates hippocamp

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12

Angelucci, Francesco, Francesca Gelfo, Marco Fiore, et al. "The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer’s disease." Canadian Journal of Physiology and Pharmacology 92, no. 8 (2014): 621–30. http://dx.doi.org/10.1139/cjpp-2014-0099.

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Alzheimer’s disease (AD) is a disorder characterized by the accumulation of abnormally folded protein fragments in neurons, i.e., β-amyloid (Aβ) and tau protein, leading to cell death. Several neuropeptides present in the central nervous system (CNS) are believed to be involved in the pathophysiology of AD. Among them, neuropeptide Y (NPY), a small peptide widely distributed throughout the brain, has generated interest because of its role in neuroprotection against excitotoxicity in animal models of AD. In addition, it has been shown that NPY modulates neurogenesis. Interestingly, these latter

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13

Chohan, Muhammad Omar, Olga Bragina, Syed Faraz Kazim, et al. "Enhancement of Neurogenesis and Memory by a Neurotrophic Peptide in Mild to Moderate Traumatic Brain Injury." Neurosurgery 76, no. 2 (2014): 201–15. http://dx.doi.org/10.1227/neu.0000000000000577.

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ABSTRACT BACKGROUND: Traumatic brain injury (TBI) is a risk factor for Alzheimer disease (AD), a neurocognitive disorder with similar cellular abnormalities. We recently discovered a small molecule (Peptide 6) corresponding to an active region of human ciliary neurotrophic factor, with neurogenic and neurotrophic properties in mouse models of AD and Down syndrome. OBJECTIVE: To describe hippocampal abnormalities in a mouse model of mild to moderate TBI and their reversal by Peptide 6. METHODS: TBI was induced in adult C57Bl6 mice using controlled cortical impact with 1.5 mm of cortical penetra

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Abdulla, Fuad A., Timothy D. Moran, Sridhar Balasubramanyan, and Peter A. Smith. "Effects and consequences of nerve injury on the electrical properties of sensory neurons." Canadian Journal of Physiology and Pharmacology 81, no. 7 (2003): 663–82. http://dx.doi.org/10.1139/y03-064.

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Nociceptive pain alerts the body to potential or actual tissue damage. By contrast, neuropathic or "noninflammatory" pain, which results from injury to the nervous system, serves no useful purpose. It typically continues for years after the original injury has healed. Sciatic nerve lesions can invoke chronic neuropathic pain that is accompanied by persistent, spontaneous activity in primary afferent fibers. This activity, which reflects changes in the properties and functional expression of Na+, K+, and Ca2+ channels, initiates a further increase in the excitability of second-order sensory neu

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15

Lee, Eun Hye, Seon Sook Kim, Seul Lee, Kwan-Hyuck Baek, and Su Ryeon Seo. "Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation." Journal of Biological Chemistry 290, no. 34 (2015): 21019–31. http://dx.doi.org/10.1074/jbc.m115.639476.

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Pituitary adenylate cyclase-activating peptide (PACAP) is a neurotrophic peptide involved in a wide range of nervous functions, including development, differentiation, and survival, and various aspects of learning and memory. Here we report that PACAP induces the expression of regulator of calcineurin 1 (RCAN1, also known as DSCR1), which is abnormally expressed in the brains of Down syndrome patients. Increased RCAN1 expression is accompanied by activation of the PKA-cAMP response element-binding protein pathways. EMSA and ChIP analyses demonstrate the presence of a functional cAMP response e

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16

Brenneman, D. E., E. A. Neale, G. A. Foster, S. W. d'Autremont, and G. L. Westbrook. "Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide." Journal of Cell Biology 104, no. 6 (1987): 1603–10. http://dx.doi.org/10.1083/jcb.104.6.1603.

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The developmental regulation of neuronal survival by vasoactive intestinal peptide (VIP) was investigated in dissociated spinal cord-dorsal root ganglion (SC-DRG) cultures. Previous studies demonstrated that VIP increased neuronal survival in SC-DRG cultures when synaptic transmission was blocked with tetrodotoxin (TTX). This effect was further investigated to determine if VIP acted directly on neurons or via nonneuronal cells. For these studies, SC-DRG cells were cultured under conditions designed to provide preparations enriched for a particular cell type: astrocyte-enriched background cell

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17

Ishiguro, Mariko, Miyuki Murayama, Akira Oomori, and Tokiko Hama. "1412 A peptide which has neurotrophic factor-like activities." Neuroscience Research Supplements 18 (January 1993): S149. http://dx.doi.org/10.1016/s0921-8696(05)81094-1.

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Igase, Keiji, Seiji Matsuda, Jyunya Tanaka, and Masahiro Sakanaka. "1236 Neurotrophic activity of prosaposin 18-mer peptide fragment." Neuroscience Research 28 (January 1997): S160. http://dx.doi.org/10.1016/s0168-0102(97)90430-2.

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19

Sheng, Shu Li, Rong Wang, Zhi Quan Ji, Fang Yang, and Jing Yan Zhang. "Amyloid protein precursor 63–73 peptide sequence is neurotrophic." Neurobiology of Aging 21 (May 2000): 258. http://dx.doi.org/10.1016/s0197-4580(00)83113-9.

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20

Dogrukol-Ak, Dilek, Vijaya B. Kumar, Jan S. Ryerse, et al. "Isolation of Peptide Transport System-6 from Brain Endothelial Cells: Therapeutic Effects with Antisense Inhibition in Alzheimer and Stroke Models." Journal of Cerebral Blood Flow & Metabolism 29, no. 2 (2008): 411–22. http://dx.doi.org/10.1038/jcbfm.2008.131.

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By isolating for the first time ever a peptide transporter from the blood—brain barrier (BBB) and developing an antisense that selectively targets the brain-to-blood efflux component, we were able to deliver a therapeutic concentration of the neurotrophic peptide pituitary adenylate cyclase-activating polypeptide (PACAP) 27 to brain in animal models of Alzheimer's and stroke. Efflux pumps at the BBB are major causes of BBB impermeability to peptides. PACAP is neuroprotective in vitro in femtomole amounts, but brain uptake of PACAP27 is limited by an efflux component of peptide transport system

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21

Roytrakul, Sittiruk, Janthima Jaresitthikunchai, Narumon Phaonakrop, et al. "Secretomic changes of amyloid beta peptides on Alzheimer’s disease related proteins in differentiated human SH-SY5Y neuroblastoma cells." PeerJ 12 (July 17, 2024): e17732. http://dx.doi.org/10.7717/peerj.17732.

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Alzheimer’s disease (AD) is a neurodegenerative disease that causes physical damage to neuronal connections, leading to brain atrophy. This disruption of synaptic connections results in mild to severe cognitive impairments. Unfortunately, no effective treatment is currently known to prevent or reverse the symptoms of AD. The aim of this study was to investigate the effects of three synthetic peptides, i.e., KLVFF, RGKLVFFGR and RIIGL, on an AD in vitro model represented by differentiated SH-SY5Y neuroblastoma cells exposed to retinoic acid (RA) and brain-derived neurotrophic factor (BDNF). The

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22

Magrì, Antonio, and Diego La Mendola. "Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link." International Journal of Molecular Sciences 19, no. 8 (2018): 2374. http://dx.doi.org/10.3390/ijms19082374.

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The nerve growth factor (NGF) is a neurotrophin essential for the development and maintenance of neurons, whose activity is influenced by copper ions. The NGF protein exerts its action by binding to its specific receptor, TrkA. In this study, a specific domain of the TrkA receptor, region 58–64, was synthesized and its copper(II) complexes characterized by means of potentiometric and spectroscopic studies. The two vicinal histidine residues provide excellent metal anchoring sites and, at physiological pH, a complex with the involvement of the peptide backbone amide nitrogen is the predominant

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23

Liu, Xingyu, Haiyuan Ren, Ai Peng, et al. "The Effect of RADA16-I and CDNF on Neurogenesis and Neuroprotection in Brain Ischemia-Reperfusion Injury." International Journal of Molecular Sciences 23, no. 3 (2022): 1436. http://dx.doi.org/10.3390/ijms23031436.

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Scaffold materials, neurotrophic factors, and seed cells are three elements of neural tissue engineering. As well-known self-assembling peptide-based hydrogels, RADA16-I and modified peptides are attractive matrices for neural tissue engineering. In addition to its neuroprotective effects, cerebral dopamine neurotrophic factor (CDNF) has been reported to promote the proliferation, migration, and differentiation of neural stem cells (NSCs). However, the role of RADA16-I combined with CDNF on NSCs remains unknown. First, the effect of RADA16-I hydrogel and CDNF on the proliferation and different

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Jarvis, C. R., Z. G. Xiong, J. R. Plant, et al. "Neurotrophin Modulation of NMDA Receptors in Cultured Murine and Isolated Rat Neurons." Journal of Neurophysiology 78, no. 5 (1997): 2363–71. http://dx.doi.org/10.1152/jn.1997.78.5.2363.

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Jarvis, C. R., Z.-G. Xiong, J. R. Plant, D. Churchill, W.-Y. Lu, B. A. MacVicar, and J. F. MacDonald. Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons. J. Neurophysiol. 78: 2363–2371, 1997. Patch-clamp and calcium imaging techniques were used to assess the acute effects of the neurotrophins, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and nerve growth factor (NGF), on the responses of cultured and acutely isolated hippocampal and cultured striatal neurons to the glutamate receptor agonist N-methyl-d-aspartic acid (NMDA). The effects of

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Lu, Jiaju, Xun Sun, Heyong Yin, et al. "A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration." Nano Research 11, no. 9 (2018): 4599–613. http://dx.doi.org/10.1007/s12274-018-2041-9.

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Shearon, Jennifer, Baylie Rushing, Madeleine Love, and Denise Head. "BLOOD-BASED CARDIAC BIOMARKERS AND PHYSICAL ACTIVITY: PRELIMINARY RESULTS." Innovation in Aging 8, Supplement_1 (2024): 1081–82. https://doi.org/10.1093/geroni/igae098.3475.

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Abstract Mixed findings regarding effects of physical activity on the brain in later adulthood motivate further research into mechanisms and moderators of potential effects. Cardiovascular health could be part of a mechanistic pathway and/or a moderator of physical activity effects. While there are myriad indicators of cardiovascular health, blood-based cardiac markers may prove particularly sensitive. One goal of this study was to investigate associations of two blood-based markers of cardiovascular health with physical activity/cardiorespiratory fitness. The second aim was to examine the mod

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O'Leary, Paul D., and Richard A. Hughes. "Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor." Journal of Biological Chemistry 278, no. 28 (2003): 25738–44. http://dx.doi.org/10.1074/jbc.m303209200.

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Valk, Gerlof D., Arnoud C. Kappelle, Aim�e M. L. Tjon-A-Tsien, et al. "Treatment of diabetic polyneuropathy with the neurotrophic peptide ORG 2766." Journal of Neurology 243, no. 3 (1996): 257–63. http://dx.doi.org/10.1007/bf00868523.

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Yao, Jie, Lina Ma, Rong Wang, Shuli Sheng, Zhijuan Ji, and Jingyan Zhang. "Neurotrophic effects of amyloid precursor protein peptide 165 in vitro." Brain Research Bulletin 120 (January 2016): 58–62. http://dx.doi.org/10.1016/j.brainresbull.2015.11.005.

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Kim, Inhyeok, Yonjae Kim, Daewoong Kang, et al. "Neuropeptides Involved in Facial Nerve Regeneration." Biomedicines 9, no. 11 (2021): 1575. http://dx.doi.org/10.3390/biomedicines9111575.

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Neuropeptides and neurotransmitters act as intermediaries to transmit impulses from one neuron to another via a synapse. These neuropeptides are also related to nerve degeneration and regeneration during nerve damage. Although there are various neuropeptides, three are associated with neural regeneration in facial nerve damage: calcitonin gene-related peptide (CGRP), galanin, and pituitary adenylyl cyclase-activating peptide (PACAP). Alpha CGRP in facial motoneurons is a signaling factor involved in neuroglial and neuromuscular interactions during regeneration. Thus, it may be a marker for fac

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Liu, Jing, Pu Chen, Hongdong Song, et al. "Prediction of Cholecystokinin-Secretory Peptides Using Bidirectional Long Short-term Memory Model Based on Transfer Learning and Hierarchical Attention Network Mechanism." Biomolecules 13, no. 9 (2023): 1372. http://dx.doi.org/10.3390/biom13091372.

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Cholecystokinin (CCK) can make the human body feel full and has neurotrophic and anti-inflammatory effects. It is beneficial in treating obesity, Parkinson’s disease, pancreatic cancer, and cholangiocarcinoma. Traditional biological experiments are costly and time-consuming when it comes to finding and identifying novel CCK-secretory peptides, and there is an urgent need to develop a new computational method to predict new CCK-secretory peptides. This study combines the transfer learning method with the SMILES enumeration data augmentation strategy to solve the data scarcity problem. It establ

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Williams, Gareth, Gareth Williams, Francisco Molina-Holgado, Francisco Molina-Holgado, Patrick Doherty, and Patrick Doherty. "Tandem Repeat Peptide Strategy for the Design of Neurotrophic Factor Mimetics." CNS & Neurological Disorders - Drug Targets 7, no. 1 (2008): 110–19. http://dx.doi.org/10.2174/187152708783885200.

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Gozes, Illana, and Irit Spivak-Pohis. "Neurotrophic Effects of the Peptide NAP: A Novel Neuroprotective Drug Candidate." Current Alzheimer Research 3, no. 3 (2006): 197–99. http://dx.doi.org/10.2174/156720506777632790.

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Grundke-Iqbal, Inge, M. Omar Chohan, Bin Li, Julie Blanchard, and Khalid Iqbal. "O4-04-08: Improvement of cognition with a neurogenic/neurotrophic peptide." Alzheimer's & Dementia 4 (July 2008): T193. http://dx.doi.org/10.1016/j.jalz.2008.05.534.

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BRENNEMAN, DOUGLAS E., TERRY M. PHILLIPS, BARRY W. FESTOFF, and ILLANA GOZES. "Identity of Neurotrophic Molecules Released from Astroglia by Vasoactive Intestinal Peptide." Annals of the New York Academy of Sciences 814, no. 1 Neuropeptides (1997): 167–73. http://dx.doi.org/10.1111/j.1749-6632.1997.tb46155.x.

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Brenneman, Douglas E., T. Nicol, D. Warren, and L. M. Bowers. "Vasoactive intestinal peptide: A neurotrophic releasing agent and an astroglial mitogen." Journal of Neuroscience Research 25, no. 3 (1990): 386–94. http://dx.doi.org/10.1002/jnr.490250316.

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Candalija, Ana, Thomas Scior, Hans-Richard Rackwitz, Jordan E. Ruiz-Castelan, Ygnacio Martinez-Laguna, and José Aguilera. "Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin." Molecules 26, no. 13 (2021): 3988. http://dx.doi.org/10.3390/molecules26133988.

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This article presents experimental evidence and computed molecular models of a potential interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of tetanus neurotoxin (Hc-TeNT). Computational simulations of a novel small cyclic oligopeptide are designed, synthesized, and tested for possible tetanus neurotoxin-D5 interaction. A hot spot of this protein-protein interaction is identified in analogy to the hitherto known crystal structures of the complex between neurotrophin and D5. Hc-TeNT activates the neurotrophin receptors, as well as its downstream signaling pathways,

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Ekberg, Karin, and Bo-Lennart Johansson. "Effect of C-Peptide on Diabetic Neuropathy in Patients with Type 1 Diabetes." Experimental Diabetes Research 2008 (2008): 1–5. http://dx.doi.org/10.1155/2008/457912.

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Recent results indicate that proinsulin C-peptide, contrary to previous views, exerts important physiological effects and shows the characteristics of a bioactive peptide. Studies in type 1 diabetes, involving animal models as well as patients, demonstrate that C-peptide in replacement doses has the ability to improve peripheral nerve function and prevent or reverse the development of nerve structural abnormalities. Peripheral nerve function, as evaluated by determination of sensory nerve conduction velocity and quantitative sensory testing, is improved by C-peptide replacement in diabetes typ

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Storey, A. T., and D. J. Kenny. "Growth, Development, and Aging of Orofacial Tissues: Neural Aspects." Advances in Dental Research 3, no. 1 (1989): 14–29. http://dx.doi.org/10.1177/08959374890030010101.

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Neural factors influence post-natal growth, development, and aging throughout the body. This influence may be mediated through sensory or motor effects interacting with endocrine and immunological factors. Growth effects may be expressed directly by sensory or motor nerves on the tissue or indirectly by motor function. Direct neurotrophic effects have been well-documented in the development of striated muscle, the taste bud, and the amphibian limb. Evidence for a trigeminal neurotrophic effect on tooth development and facial development is lacking. Growth disturbances of the jaws consequent to

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Ju, Da-Tong, Ashok Kumar K., Wei-Wen Kuo, et al. "Bioactive Peptide VHVV Upregulates the Long-Term Memory-Related Biomarkers in Adult Spontaneously Hypertensive Rats." International Journal of Molecular Sciences 20, no. 12 (2019): 3069. http://dx.doi.org/10.3390/ijms20123069.

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Hypertension is one of the growing risk factors for the progression of long-term memory loss. Hypertension-mediated memory loss and treatment remain not thoroughly elucidated to date. Plant-based natural compounds are an alternative solution to treating human diseases without side effects associated with commercial drugs. This study reveals that bioactive peptides extracted from soy hydrolysates mimic hypertension-mediated memory loss and neuronal degeneration and alters the memory molecular pathway in spontaneously hypertensive rats (SHR). The SHR animal model was treated with bioactive pepti

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Liu, Mingchuan, Shengjie Yang, Jinping Yang, Yita Lee, Junping Kou, and Chaojih Wang. "Neuroprotective and Memory-Enhancing Effects of Antioxidant Peptide From Walnut (Juglans regia L.) Protein Hydrolysates." Natural Product Communications 14, no. 7 (2019): 1934578X1986583. http://dx.doi.org/10.1177/1934578x19865838.

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Peptides have been reported to possess interesting biological properties. The present study was designed to evaluate neuroprotective and memory-enhancing effects of antioxidant peptide from walnut ( Juglans regia L.) protein hydrolysates. The neuroprotective effect of walnut peptide (WP) against oxidative stress on PC12 cells was evaluated. And zebrafish was used as the model to corroborate the effect. Its effect on learning and memory of mice using the Morris water maze and the step-down passive avoidance tests were performed. Moreover, the acute toxicity of WP was carried out to assess its s

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Nikitina, Alexandra A., Svetlana G. Belokoskova, Victoria A. Maystrenko, et al. "The participation of monoamines in the realization of vasopressin analgesic effects during electrical stimulation of paws in rats." Medical academic journal 24, no. 2 (2024): 45–52. http://dx.doi.org/10.17816/maj633203.

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BACKGROUND: Arginine vasopressin has been implicated in the modulation of stress and pain. The influence of a synthetic analogue of arginine vasopressin, 1-deamino-8-D-arginine-vasopressin, оn pain sensitivity, stress reactivity, levels of monoamines and brain neurotrophic factor in a model of paw electrical stimulation in rats has not been studied. AIM: The aim was to evaluate the effect of a synthetic vasopressin analog, 1-deamino-8-D-arginine-vasopressin, on pain sensitivity and the content of norepinephrine, serotonin, dopamine, brain neurotrophic factor in the parietal cortex and spinal c

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Gul, Huseyin Fatih, Caner Yildirim, Can Emre Erdogan, Ozlem Gul та Nazlı Koc. "The Role of Galanin, Alarin, Irisin, PGC1-Α and BDNF in the Pathophysiology of Alzheimer's disease". International Journal of Medical Science and Clinical Invention 8, № 06 (2021): 5498–507. http://dx.doi.org/10.18535/ijmsci/v8i06.09.

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The roles of novel peptides such as peroxisome proliferator-activated receptor gamma coactivator 1- alpha (PGC1-α), irisin, brain-derived neurotrophic factor (BDNF), galanin and alarin in Alzheimer's disease (AD) are not fully known. It was aimed to plasma levels of the novel peptides that may affect the pathophysiology of AD were examined. This study was conducted as a cross-sectional. The study consisted of two groups, including 45 newly diagnosed individuals with AD and 45 healthy individuals. The peptide levels in plasma samples collected from the groups were measured by the ELISA method.

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Kim, Sokho, Jihye Choi, and Jungkee Kwon. "Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106–126) via Neurotrophic Factor Signaling." Molecules 28, no. 9 (2023): 3920. http://dx.doi.org/10.3390/molecules28093920.

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Prion protein peptide (PrP) has demonstrated neurotoxicity in brain cells, resulting in the progression of prion diseases with spongiform degenerative, amyloidogenic, and aggregative properties. Thymosin beta 4 (Tβ4) plays a role in the nervous system and may be related to motility, axonal enlargement, differentiation, neurite outgrowth, and proliferation. However, no studies about the effects of Tβ4 on prion disease have been performed yet. In the present study, we investigated the protective effect of Tβ4 against synthetic PrP (106–126) and considered possible mechanisms. Hippocampal neurona

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Priestley, J. V., G. J. Michael, S. Averill, M. Liu, and N. Willmott. "Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor." Canadian Journal of Physiology and Pharmacology 80, no. 5 (2002): 495–505. http://dx.doi.org/10.1139/y02-034.

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Nociceptive dorsal root ganglion (DRG) cells can be divided into three main populations, namely (1) small diameter non-peptide-expressing cells, (2) small-diameter peptide-expressing (calcitonin gene related peptide (CGRP), substance P) cells, and (3) medium-diameter peptide-expressing (CGRP) cells. The properties of these cell populations will be reviewed, with a special emphasis on the expression of the vanilloid (capsaicin) receptor VR1 and its regulation by growth factors. Cells in populations 1 and 2 express VR1, a nonselective channel that transduces certain nociceptive stimuli and that

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Perlikowska, Renata, Angelika Długosz-Pokorska, Małgorzata Domowicz, Sylwia Grabowicz, Mariusz Stasiołek, and Małgorzata Zakłos-Szyda. "Reduction in SH-SY5Y Cell Stress Induced by Corticosterone and Attenuation of the Inflammatory Response in RAW 264.7 Cells Using Endomorphin Analogs." Biomedicines 13, no. 7 (2025): 1774. https://doi.org/10.3390/biomedicines13071774.

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Background: To identify drug candidates that reduce cellular stress, linear peptides known as endomorphin (EM) analogs containing proline surrogates in position 2 were tested in in vitro injury models induced by corticosterone (CORT). Methods: In this study, neuroblastoma (SH-SY5Y) cells were treated with CORT and synthesized peptides, and then the cell viability and morphology, reactive oxygen species production (ROS), mitochondrial membrane potential (ΔΨm), adenosine triphosphate (ATP), and intracellular calcium ion [Ca2+]i levels were evaluated. We also conducted an in-depth analysis of the

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Safruddin, Khairu Zein, Ardhin Martdana, Fenska Seipalla, and Tirza Sosanta. "Organoruthenium 9E1 and APL Altered Collagen II263-272 Peptide as Therapy for Autoimmune Diseases." Journal of Health Science and Medical Therapy 1, no. 02 (2023): 61–70. http://dx.doi.org/10.59653/jhsmt.v1i02.277.

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Therapy for autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (MS) is currently available in symptom management, pain-relieving, and mitigation of disease. Currently, prescribed drugs for patients with the disease work in specific mechanisms, regardless of failure to determine the most effective medication. We use a literature review to highlight two newly examined substances: organoruthenium 9E1 and APL altered collagen II263-272 peptide, and elaborate substances mentioned above' potential to be used in rheumatoid arthritis and MS therapy. Several studies show positive e

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Yue, Mengyun, Jing Wei, Wenjie Chen, Daojun Hong, Tingtao Chen, and Xin Fang. "Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis." Nutrients 14, no. 22 (2022): 4886. http://dx.doi.org/10.3390/nu14224886.

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Parkinson’s disease (PD) is a neurodegenerative disease (NDD) with high and ongoing morbidity, bringing heavy burdens to PD patients seriously. Finding neurotrophic drugs still remains vital due to the limited drug spectrum available currently. Substantial evidence suggests that glucagon-like peptide 1 (GLP-1) exerts neuroprotection on PD, yet the short-lived biological activity markedly hindered its application. Herein, we investigated the neurotrophic role of the next-generation probiotic strain L. lactis MG1363-pMG36e-GLP-1 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD m

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Xiao, Junhua, Richard A. Hughes, Joe Y. Lim, et al. "A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination." Journal of Neurochemistry 125, no. 3 (2013): 386–98. http://dx.doi.org/10.1111/jnc.12168.

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Lim, Juhee, Seokhee Kim, Changhyun Lee, Jeongwoo Park, Gabsik Yang, and Taehan Yook. "Verbenalin Reduces Amyloid-Beta Peptide Generation in Cellular and Animal Models of Alzheimer’s Disease." Molecules 27, no. 24 (2022): 8678. http://dx.doi.org/10.3390/molecules27248678.

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Verbenalin, among the major constituents of Verbena officinalis, has been reported to exhibit sleep-promoting and antioxidant activities. This study demonstrates the effects of verbenalin on amyloid-beta (Aβ) peptide generation in Swedish mutant amyloid precursor protein (APP)-overexpressing Neuro2a cells (SweAPP/N2a) and in Alzheimer’s disease (AD) animal models. We further performed molecular biological analyses of these in vitro and in vivo models of AD. The effects of verbenalin were assessed based on the expression of factors related to Aβ peptide production using Western blotting, enzyme

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