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1

White, Jane S., John M. Tobin, and Joseph J. Cooney. "Organotin compounds and their interactions with microoganisms." Canadian Journal of Microbiology 45, no. 7 (1999): 541–54. http://dx.doi.org/10.1139/w99-048.

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Organotin compounds are ubiquitous in the environment. The general order of toxicity to microorganisms increases with the number and chain length of organic groups bonded to the tin atom. Tetraorganotins and inorganic tin have little toxicity. Because of their lipophilicity, organotins are regarded as membrane active. There is evidence that the site of action of organotins may be both at the cytoplasmic membrane and intracellular level. Consequently, it is not known whether cell surface adsorption or accumulation within the cell, or both is a prerequisite for toxicity. Biosorption studies on a
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2

Podestá, J. C., A. B. Chopa, A. D. Ayala, and L. C. Koll. "Organotin compounds." Journal of Organometallic Chemistry 333, no. 1 (1987): 25–36. http://dx.doi.org/10.1016/s0022-328x(00)99028-4.

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3

Ayala, A. D., N. Giagante, J. C. Podestá, and W. P. Neumann. "Organotin compounds." Journal of Organometallic Chemistry 340, no. 3 (1988): 317–29. http://dx.doi.org/10.1016/0022-328x(88)80025-1.

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4

Podestá, Julio C., Alicia D. Ayala, Alicia B. Chopa, and Nelda N. Giagante. "Organotin compounds." Journal of Organometallic Chemistry 364, no. 1-2 (1989): 39–55. http://dx.doi.org/10.1016/0022-328x(89)85329-x.

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5

Martin, F., FM Corrigan, Ofx Donard, J. Kelly, Jao Besson, and DF Horrobin. "Organotin compounds in trimethyltin-treated rats and in human brain in Alzheimer's Disease." Human & Experimental Toxicology 16, no. 9 (1997): 512–15. http://dx.doi.org/10.1177/096032719701600906.

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As blood tin concentrations are elevated in Alzheimer's disease and as some low molecular weight organotin compounds are neurotoxic, we have attempted to detect organotins in brain in Alzheimer's Disease. First we measured the concentration of trimethyltin (TMT) in the brains of rats which had been exposed to memory- impairing concentrations of TMT and, as the method of linking hydride generation, cryogenic trapping, gas chromatographic separation and atomic absorption spec trophotometric detection permitted the measurements of organotin compounds when the total tin was greater than 0.2 nanogr
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6

Terraza, V. Fabricio, Darío C. Gerbino, and Julio C. Podestá. "Stereoselective Hydrostannation of Diacrylate and Dimethacrylate Esters of Galactaric Acid Derivatives: Cyclohydrostannation vs. Diaddition." Proceedings 9, no. 1 (2018): 55. http://dx.doi.org/10.3390/ecsoc-22-05688.

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This paper reports a study on the free radical hydrostannation of ((4S,4′R,5R,5′S)-2,2,2′,2′-tetramethyl-[4,4′-bi(1,3-dioxolane)]-5,5′-diyl)bis(diphenyl methylene) diacrylate (1) and dimethacrylate (2) with triorganotin hydrides, R3SnH (R = Me, n-Bu, Ph). Preliminary investigations show that these reactions could lead to mixtures of products of cyclohydrostannation and/or mono- or diaddition according to the organotin hydrides employed and the reaction conditions used. The addition of Me3SnH to 1 afforded a mixture of three organotin compounds from which the pure new 13-membered macrodiolide 3
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7

Cheng, Shuming, and Jing Yang. "A Theoretical Study of Organotin Binding in Aromatase." International Journal of Molecular Sciences 24, no. 10 (2023): 8954. http://dx.doi.org/10.3390/ijms24108954.

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The widely used organotin compounds are notorious for their acute toxicity. Experiments revealed that organotin might cause reproductive toxicity by reversibly inhibiting animal aromatase functioning. However, the inhibition mechanism is obscure, especially at the molecular level. Compared to experimental methods, theoretical approaches via computational simulations can help to gain a microscopic view of the mechanism. Here, in an initial attempt to uncover the mechanism, we combined molecular docking and classical molecular dynamics to investigate the binding between organotins and aromatase.
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8

Fent, Karl. "Ecotoxicology of Organotin Compounds." Critical Reviews in Toxicology 26, no. 1 (1996): 3–117. http://dx.doi.org/10.3109/10408449609089891.

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9

Fait, Antonella, Adalberto Ferioli, and Franco Barbieri. "Chapter 11 Organotin compounds." Toxicology 91, no. 1 (1994): 77–82. http://dx.doi.org/10.1016/0300-483x(94)90244-5.

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10

Appel, Klaus E. "Organotin Compounds: Toxicokinetic Aspects." Drug Metabolism Reviews 36, no. 3-4 (2004): 763–86. http://dx.doi.org/10.1081/dmr-200033490.

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11

Brown, Paul, Mary F. Mahon, and Kieran C. Molloy. "Sterically hindered organotin compounds." Journal of Organometallic Chemistry 435, no. 3 (1992): 265–73. http://dx.doi.org/10.1016/0022-328x(92)83397-z.

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12

Dodokhova, Margarita A., Andrei V. Safronenko, Inga M. Kotieva, Margarita S. Alkhuseyn-Kulyaginova, Dmitry B. Shpakovsky, and Elena R. Milaeva. "Impact of organotin compounds on the growth of epidermoid Lewis carcinoma." Research Results in Pharmacology 7, no. (4) (2021): 81–88. https://doi.org/10.3897/rrpharmacology.7.71455.

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Introduction: Search for new compounds with a broad antitumor and antimetastatic potency due to multiple targeting remains important in medicinal chemistry, pharmacology and oncology. We report the efficacy of hybrid organotin agents bis-(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Ме3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Ме5). Materials and methods: The compounds were administered to mice bearing the spontaneously metastatic epidermoid Lewis lung carcinoma (LLC). The efficacy of the treatment was evaluated by mean life span, percentage of tumor growth inh
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13

Rabiee, Navid, Moein Safarkhani, and Mostafa M. Amini. "Investigating the structural chemistry of organotin(IV) compounds: recent advances." Reviews in Inorganic Chemistry 39, no. 1 (2019): 13–45. http://dx.doi.org/10.1515/revic-2018-0014.

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AbstractOrganotin(IV) compounds have been considered for their outstanding industrial, medical and specific applications in the synthesis of various types of chemical compounds. In this review, we have focused on the structural chemistry of organotin(IV) compounds, including coordination chemistry, the effect of structure on reactions, bond formations from the perspective of structure and investigation of the structure of organotin(IV) compounds in different phases. The structural chemistry of organotin(IV) compounds is subject to interest due to their major impact on predicting the properties
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14

Abd Aziz, Nurul Amalina, Normah Awang, Kok Meng Chan, Nurul Farahana Kamaludin, and Nur Najmi Mohamad Anuar. "Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies." Molecules 28, no. 15 (2023): 5841. http://dx.doi.org/10.3390/molecules28155841.

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Organotin (IV) dithiocarbamate has recently received attention as a therapeutic agent among organotin (IV) compounds. The individual properties of the organotin (IV) and dithiocarbamate moieties in the hybrid complex form a synergy of action that stimulates increased biological activity. Organotin (IV) components have been shown to play a crucial role in cytotoxicity. The biological effects of organotin compounds are believed to be influenced by the number of Sn-C bonds and the number and nature of alkyl or aryl substituents within the organotin structure. Ligands target and react with molecul
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15

Dodokhova, Margarita A., Andrei V. Safronenko, Inga M. Kotieva, Margarita S. Alkhuseyn-Kulyaginova, Dmitry B. Shpakovsky, and Elena R. Milaeva. "Impact of organotin compounds on the growth of epidermoid Lewis carcinoma." Research Results in Pharmacology 7, no. 4 (2021): 81–88. http://dx.doi.org/10.3897/rrpharmacology.7.71455.

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Introduction: Search for new compounds with a broad antitumor and antimetastatic potency due to multiple targeting remains important in medicinal chemistry, pharmacology and oncology. We report the efficacy of hybrid organotin agents bis-(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Ме3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Ме5). Materials and methods: The compounds were administered to mice bearing the spontaneously metastatic epidermoid Lewis lung carcinoma (LLC). The efficacy of the treatment was evaluated by mean life span, percentage of tumor growth inh
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16

Allef, Petra, та Horst Kunz. "Stereoselective Synthesis of α-Arylalkylamines by Glycosylation-induced Asymmetric Addition of Organometallic Compounds to Imines". Zeitschrift für Naturforschung B 64, № 6 (2009): 646–52. http://dx.doi.org/10.1515/znb-2009-0609.

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Activation of imines of aromatic aldehydes by N-glycosylation with O-pivaloyl-galactopyranosyl bromide (pivalobromogalactose) and subsequent addition of organotin, organolithium, Grignard, or organozinc reagents afforded α-arylalkylamines with moderate to high diastereoselectivity.
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17

Sun, Jinnuo, Ya Yang, Suyu Fan, Rui Wang, and Qinghui Huang. "The Spatial Variation in Organotin Contamination in Different Environmental Media: A Case of the Lower Yangtze River in China." Water 16, no. 21 (2024): 3126. http://dx.doi.org/10.3390/w16213126.

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With the global ban on tributyltin (TBT), the pollution of triphenyltin (TPhT) is an emerging issue in some aquatic ecosystems. In this study, we investigated the concentrations of typical butyltin and phenyltin compounds in the surface water and sediments in the lower Yangtze River, analyzed their occurrence and sources, and assessed their ecological risks. The findings indicate that butyltin and phenyltin compounds are widespread. The total concentration of organotin compounds in surface water was as high as 42.41 ng Sn/L, with an average of 25.71 ng Sn/L, and the total concentration of orga
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18

Plasseraud, Laurent. "Organotin(IV) Complexes Containing Sn–O–Se Moieties: A Structural Inventory." Synthesis 50, no. 18 (2018): 3653–61. http://dx.doi.org/10.1055/s-0037-1610164.

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This review focuses on organotin compounds exhibiting Sn–O–Se moieties, the molecular structures of which have been previously resolved by single-crystal X-ray diffraction analysis. Three distinct classes of compounds have been identified. Thus, the various modes of coordination of selenite, selenate and organoseleninate anions with tin atoms of organotin(IV) fragments are illustrated and detailed.1 Introduction2 Organotin(IV) Selenite Complexes3 Organotin(IV) Selenate Complexes4 Organotin(IV) Organoseleninate Complexes5 Summary
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19

Ibadi, Falih, Emad Yousif, Mohammed Al-Mashhadani, Nany Hairunisa, and Muna Bufaroosh. "Recent Studies on Cancer Cell's Inhibition by Organotin (IV) Materials: An Overview." Al-Nahrain Journal of Science 26, no. 2 (2023): 23–29. http://dx.doi.org/10.22401/anjs.26.2.04.

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organotin (IV) compounds have been the focus of recent studies for their potential use in the treatment of cancer. This review provides an overview of recent studies on the inhibition of cancer cells by organotin (IV) materials. The literature suggests that organotin (IV) compounds can selectively target cancer cells and induce apoptosis, making them promising candidates for anticancer drugs. The review covers various types of organotin (IV) compounds, including those containing alkyl, aryl, and amino groups, and their mechanisms of action against cancer cells. Additionally, the study explores
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20

Rasli, Nur Rasyiqin, Asmah Hamid, Normah Awang, and Nurul Farahana Kamaludin. "Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells." Molecules 28, no. 8 (2023): 3376. http://dx.doi.org/10.3390/molecules28083376.

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The discovery of cisplatin has influenced scientists to study the anticancer properties of other metal complexes. Organotin(IV) dithiocarbamate compounds are gaining attention as anticancer agents due to their potent cytotoxic properties on cancer cells. In this study, a series of organotin compounds were assessed for their toxic effects on the Jurkat E6.1 cell line. WST-1 assay was used to determine the cytotoxic effect of the compounds and showed that six out of seven organotin(IV) dithiocarbamate compounds exhibited potent cytotoxic effects toward T-lymphoblastic leukemia cells, Jurkat E6.1
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21

Ghani, Hassan, and Emad Yousif. "Chemistry of Some Organotin Compounds." Al-Nahrain Journal of Science 24, no. 3 (2021): 9–15. http://dx.doi.org/10.22401/anjs.24.3.02.

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Organotin compounds (OTCs) are characterized as having at minimum one covalent bond between carbon and tin atoms, and are usually denoted by the formula RnSnX4-n (n =1-3, R =aryl or alkyl, X =halogen ion or a carboxylate, etc.). There are several methods to synthesis organotin compounds, they are Grignard and Kocheshkov reactions, Wurtz reaction and alkylation method. The tin has two stable state,(II) and (IV). Sn(II) forms pyramidal sp3complexes as well as trigonal bipyramidal sp3d complexes, whereas Sn(IV) forms trigonal bipyramidal sp3d complexes or octahedral sp3d2complexes.
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22

Saito, Haruko. "Health effects of organotin compounds." Japan journal of water pollution research 10, no. 12 (1987): 719–25. http://dx.doi.org/10.2965/jswe1978.10.719.

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23

Pichler, Johann, Philipp Müller, Ana Torvisco, and Frank Uhlig. "Novel diaminopropyl substituted organotin compounds." Canadian Journal of Chemistry 96, no. 4 (2018): 411–18. http://dx.doi.org/10.1139/cjc-2017-0713.

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A novel synthetic pathway involving the desilylation of a tin trimethylsilyl species (Ph2Sn(SiMe3)2) towards nonprotected di(3-aminopropyl)tin dichloride ((H2N(CH2)3)2SnCl2) is described. Di(3-aminopropyl)tin dichloride is then converted to the respective dicarboxylates species (H2N(CH2)3)2Sn(OCOR)2 containing carboxylic acids of different lengths (R = –CH3, –(CH2)10CH3). Depending on the nature of R, discrete packing effects are observed in the solid state of di(3-aminopropyl)tin dicarboxylate derivatives. All the synthesized substances were characterized by 1H, 13C, and 119Sn nuclear magneti
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24

Ross, Alexander. "INDUSTRIAL APPLICATIONS OF ORGANOTIN COMPOUNDS." Annals of the New York Academy of Sciences 125, no. 1 (2006): 107–23. http://dx.doi.org/10.1111/j.1749-6632.1965.tb45382.x.

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25

Ritter, Kurt. "Claisen rearrangement of organotin compounds." Tetrahedron Letters 31, no. 6 (1990): 869–72. http://dx.doi.org/10.1016/s0040-4039(00)94650-1.

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26

Davies, Alwyn G. "Organotin Compounds in Modern Technology." Journal of Organometallic Chemistry 293, no. 1 (1985): C22. http://dx.doi.org/10.1016/0022-328x(85)80262-x.

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27

Lin, Ja-Liang, and Swei Hsueh. "Acute Nephropathy of Organotin Compounds." American Journal of Nephrology 13, no. 2 (1993): 124–28. http://dx.doi.org/10.1159/000168601.

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28

MIMURA, HARUO. "Biological toxicity of organotin compounds." Kagaku To Seibutsu 32, no. 6 (1994): 405–8. http://dx.doi.org/10.1271/kagakutoseibutsu1962.32.405.

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29

Barbieri, Renato, Arturo Silvestri, Anna M. Giuliani, Vincenzo Piro, Francesco Di Simone, and Grazia Madonia. "Organotin compounds and deoxyribonucleic acid." Journal of the Chemical Society, Dalton Transactions, no. 4 (1992): 585. http://dx.doi.org/10.1039/dt9920000585.

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30

Meinema, Harry. "Organotin Compounds in Modern Technology." Organometallics 4, no. 9 (1985): 1696. http://dx.doi.org/10.1021/om00128a602.

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31

Saxena, A. K., and F. Huber. "Organotin compounds and cancer chemotherapy." Coordination Chemistry Reviews 95, no. 1 (1989): 109–23. http://dx.doi.org/10.1016/0010-8545(89)80003-7.

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32

Zhou, Qun-fang, Gui-bin Jiang, and Ji-yan Liu. "Organotin Pollution in China." Scientific World JOURNAL 2 (2002): 655–59. http://dx.doi.org/10.1100/tsw.2002.136.

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A preliminary investigation of the occurrence of butyltin compounds was made in various environmental samples including water, sediment, sea products, and other commodities from China. Detection was carried out by the method of hydrogenation coupled with SPME or Grignard derivatization, followed by GC-FPD analysis. The results showed the universal existence of butyltin compounds in a wide range of tested samples, which was a potential danger for human health. Urgent control or management of organotin compounds is necessary to prevent the underlying hazard caused by this kind of pollutant.
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33

Eaborn, Colin. "Gmelin handbook of inorganic and organometallic chemistry. 8th Ed. Sn. organotin compounds. Part 19. Organotin-nitrogen compounds (concluded), Organotin-Phosphorus, -Arsenic, -Antimony, -Bismuth Compounds." Journal of Organometallic Chemistry 436, no. 2 (1992): C22. http://dx.doi.org/10.1016/0022-328x(92)85056-3.

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34

Storozhenko, P. A., K. D. Magdeev, A. A. Grachev, N. I. Kirilina, and V. I. Shiryaev. "Organotin Compounds in Industrial Catalysis. II. Polyurethanes Formation Processes." Kataliz v promyshlennosti 20, no. 3 (2020): 203–15. http://dx.doi.org/10.18412/1816-0387-2020-3-203-215.

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This is the second part of a series of reviews on the application of organotin compounds as the catalysts for some important industrial processes. This review considers the application of organotin compounds in the processes of polyurethanes formation.
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35

Yusof, Enis Nadia Md, Muhammad A. M. Latif, Mohamed I. M. Tahir, et al. "o-Vanillin Derived Schiff Bases and Their Organotin(IV) Compounds: Synthesis, Structural Characterisation, In-Silico Studies and Cytotoxicity." International Journal of Molecular Sciences 20, no. 4 (2019): 854. http://dx.doi.org/10.3390/ijms20040854.

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Six new organotin(IV) compounds of Schiff bases derived from S-R-dithiocarbazate [R = benzyl (B), 2- or 4-methylbenzyl (2M and 4M, respectively)] condensed with 2-hydroxy-3-methoxybenzaldehyde (oVa) were synthesised and characterised by elemental analysis, various spectroscopic techniques including infrared, UV-vis, multinuclear (1H, 13C, 119Sn) NMR and mass spectrometry, and single crystal X-ray diffraction. The organotin(IV) compounds were synthesised from the reaction of Ph2SnCl2 or Me2SnCl2 with the Schiff bases (S2MoVaH/S4MoVaH/SBoVaH) to form a total of six new organotin(IV) compounds th
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36

Paredes-Cervantes, Vladimir, Jane Castillo-Vera, Federico Gomez-Reynoso, Francisco Diaz-Cedillo, and Miguel Aguilar-Santelises. "Wastewater from Mexico City contains organotin compounds and organotin-resistant bacteria." Cogent Environmental Science 3, no. 1 (2017): 1347996. http://dx.doi.org/10.1080/23311843.2017.1347996.

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37

Lima, Aline Fernandes Alves de, Ítalo Braga de Castro, and Cristina de Almeida Rocha-Barreira. "Imposex induction in Stramonita haemastoma floridana (Conrad, 1837) (Mollusca: Gastropoda: Muricidae) submitted to an organotin-contaminated diet." Brazilian Journal of Oceanography 54, no. 1 (2006): 85–90. http://dx.doi.org/10.1590/s1679-87592006000100008.

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Marine organisms are affected by organotin compounds due to the cumulative, deleterious effects of these latter. The most evident and well known consequence of organotin contamination is imposex, a hormonal disruption that causes a superimposition of sexual male features in females of prosobranchia neogastropod molluscs such as Stramonita haemastoma floridana. Molluscs accumulate organotins mainly because of their poor ability to eliminate TBT and DBT from their tissues. The aim of this study was to analyze organotin uptake by ingestion experimentally, using uncontaminated subjects (S. haemast
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38

Beg, Mohd A., Md A. Beg, Ummer R. Zargar, et al. "Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights." Toxics 11, no. 1 (2022): 25. http://dx.doi.org/10.3390/toxics11010025.

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Organotin compounds (OTCs) are a commercially important group of organometallic compounds of tin used globally as polyvinyl chloride stabilizers and marine antifouling biocides. Worldwide use of OTCs has resulted in their ubiquitous presence in ecosystems across all the continents. OTCs have metabolic and endocrine disrupting effects in marine and terrestrial organisms. Thus, harmful OTCs (tributyltin) have been banned by the International Convention on the Control of Harmful Antifouling Systems since 2008. However, continued manufacturing by non-member countries poses a substantial risk for a
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39

Milaeva, E. R., M. A. Dodokhova, D. B. Shpakovsky, et al. "Mechanisms of the Cytotoxic Action of Organotin Compounds." Journal Biomed 17, no. 2 (2021): 88–99. http://dx.doi.org/10.33647/2074-5982-17-2-88-99.

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This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates
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40

Davies, Alwyn G. "Organotin compounds in technology and industry." Journal of Chemical Research 2010, no. 4 (2010): 181–90. http://dx.doi.org/10.3184/030823410x12698696585509.

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41

Herber, Rolfe H., and Israel Nowik. "Metal Atom Dynamics of Organotin Compounds." Phosphorus, Sulfur, and Silicon and the Related Elements 186, no. 6 (2011): 1336–40. http://dx.doi.org/10.1080/10426507.2010.543103.

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42

Baba, Ibrahim, Amirah Faizah Abdul Muthalib, Yang Farina Abdul Aziz, and Ng Seik Weng. "New Dithiocarbamate Compounds from Organotin(IV)." Phosphorus, Sulfur, and Silicon and the Related Elements 186, no. 6 (2011): 1326–29. http://dx.doi.org/10.1080/10426507.2010.548841.

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43

Joshi, Ravi R., and Sudhir K. Gupta. "Ecotoxicity studies of some organotin compounds." Toxicological & Environmental Chemistry 34, no. 2-4 (1992): 133–38. http://dx.doi.org/10.1080/02772249209357786.

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44

Mitchell, Terence N. "Palladium-Catalysed Reactions of Organotin Compounds." Synthesis 1992, no. 09 (1992): 803–15. http://dx.doi.org/10.1055/s-1992-26230.

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45

Dubalska, Kinga, Małgorzata Rutkowska, Gabriela Bajger-Nowak, Piotr Konieczka, and Jacek Namieśnik. "Organotin Compounds: Environmental Fate and Analytics." Critical Reviews in Analytical Chemistry 43, no. 1 (2013): 35–54. http://dx.doi.org/10.1080/10408347.2012.743846.

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46

Sakai, Fumihiko, Hideaki Fujiwara, and Yoshio Sasaki. "The solution chemistry of organotin compounds." Journal of Organometallic Chemistry 310, no. 3 (1986): 293–301. http://dx.doi.org/10.1016/0022-328x(86)80193-0.

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