Artigos de revistas: "Presbycusi"

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Kim, Sang Hoon, e Seung Geun Yeo. "Presbycusis". Hanyang Medical Reviews 35, n.º 2 (2015): 78. http://dx.doi.org/10.7599/hmr.2015.35.2.78.

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Gates, George A., e John H. Mills. "Presbycusis". Lancet 366, n.º 9491 (setembro de 2005): 1111–20. http://dx.doi.org/10.1016/s0140-6736(05)67423-5.

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Gates, George A., Donald M. Caspary, William Clark, Harold C. Pillsbury, Scott Campbell Brown e Robert A. Dobie. "Presbycusis". Otolaryngology–Head and Neck Surgery 100, n.º 4 (abril de 1989): 266–71. http://dx.doi.org/10.1177/019459988910000403.

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Schuknecht, Harold F., e Mark R. Gacek. "Cochlear Pathology in Presbycusis". Annals of Otology, Rhinology & Laryngology 102, n.º 1_suppl (janeiro de 1993): 1–16. http://dx.doi.org/10.1177/00034894931020s101.

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A survey of the temporal bone collection at the Massachusetts Eye and Ear Infirmary reveals 21 cases that meet the criterion for the clinical diagnosis of presbycusis. It is evident that the previously advanced concept of four predominant pathologic types of presbycusis is valid, these being sensory, neural, strial, and cochlear conductive. An abrupt high-tone loss signals sensory presbycusis, a flat threshold pattern is indicative of strial presbycusis, and loss of word discrimination is characteristic of neural presbycusis. When the increments of threshold loss present a gradually decreasing linear distribution pattern on the audiometric scale and have no pathologic correlate, it is speculated that the hearing loss is caused by alterations in the physical characteristics of the cochlear duct, and the loss is identified as cochlear conductive presbycusis. It is clear that many individual cases do not separate into a specific type but have mixtures of these pathologic types and are termed mixed presbycusis. About 25% of all cases of presbycusis show none of the above characteristics and are classified as indeterminate presbycusis.

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Amin Onn, Mohammed, Khairi Md Daud e Rosdan Salim. "Prevalence of Vestibular Dysfunction with Presbycusis among Elderly in Malaysia". Pakistan Journal of Medical and Health Sciences 15, n.º 12 (30 de dezembro de 2021): 3478–80. http://dx.doi.org/10.53350/pjmhs2115123478.

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Objectives: This study aims to determine the prevalence of vestibular dysfunction in the Malaysian elderly and its association with presbycusis, age and other associated risk factors. Methods: A cross-sectional study was undertaken in a tertiary otorhinolaryngology department and the community. Adults aged 60 years and above who attended the ORL CLINIC with or without presbycusis were invited to participate. The main outcome measures, including the Malay Version Vertigo Symptoms Scale, pure tone audiometry and vestibular assessment, were obtained using a Video Head Impulse Test (VHIT). Results: The prevalence of vestibular dysfunction with presbycusis in the study population of 135 participants was 46.7 per cent (95 per cent confidence interval, 24.0 to 36.2 per cent). The median age was 68 years (range, 60–86 years). The A chi-square test of independence showed that there was significant association between Presbycusis and Tinnitus, X2 (1, N = 135) = 97.37, p < .001. A chi-square test of independence was performed to examine the relation between presbycusis and dizziness. The relation between these variables was significant, X2 (2, N = 135) = 28.42, p < .001. A chi-square test of independence showed that there was no significant association between presbycusis and VHIT, X2 (1, N = 135) = .01, p = .938. Conclusion: Vestibular dysfunction is independently associated with ageing and presbycusis. More research investigating the advantages of additional screening for vestibular dysfunction in older presbycusis patients is needed. Key words: Elderly; Presbycusis; Vestibular dysfunction; Video Head Impulse Test (VHIT)

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Ario, Manuel M., Ratna Anggraeni e Nur A. Aroeman. "The Characteristics of Patients with Presbycusis in Bandung in 2019". Journal of Medicine and Health 4, n.º 1 (27 de fevereiro de 2022): 7. http://dx.doi.org/10.28932/jmh.v4i1.3328.

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Presbycusis is a progressive hearing loss that is associated with aging. The audiogram shows a sensorineural hearing loss at high frequency on both side. Hearing loss is the second largest disability experienced by the elderly with 30-35% of people aged 65-75 years experiencing presbycusis in Indonesia. This study aims to review the characteristics of patients with presbycusis in Bandung. This is a descriptive cross-sectional study, conducted from March to May 2019 at the West Java Province Social Protection Center, Dorkas Nursing Home, and Alamanda Nursing Home. The inclusion criteria was all residents with hearing loss and the exclusion criteria was congenital deafness. This study was participated by 135 subjects, 87 women (64.44%) and 48 men (35.56%). Presbycusis was found mainly in 63 women (71.59%), older than 65 years (57.95%), with moderate (32.95%) sensorineural and mixed hearing loss (65.19%). The most common symptom complained was tinnitus (68.18%). In conclusion, presbycusis was mainly found in female aged ?65 years old, with tinnitus and moderate hearing loss as chief complaint. The most common comorbidity was hypertension. However, in individuals with risk factors, presbycusis can be found sooner. Keywords: hearing loss, sensorineural, elderly, presbycusis

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Kang, Min Ju, Youngin Lee, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Yu Hyeon Yi, Young Hye Cho et al. "Association between Sleep Duration and Presbycusis in Korean Adults: Korea National Health and Nutrition Examination Survey". Korean Journal of Family Medicine 44, n.º 2 (20 de março de 2023): 117–23. http://dx.doi.org/10.4082/kjfm.22.0137.

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Background: Sleep duration is associated with hearing loss, especially presbycusis, which is the most common type of hearing loss; however, there is limited evidence regarding this association among the Korean population. We aimed to determine the relationship between sleep duration and high-frequency hearing loss in Korean adults aged ≥40 years.Methods: We examined 5,547 Korean adults aged ≥40 years who completed audiometric tests and questionnaires regarding sleep duration during the 2010–2012 cycle of the Korea National Health and Nutrition Examination Survey. Mild presbycusis was defined as >25 decibels (dB) and <40 dB, whereas moderate-to-severe presbycusis was defined as >40 dB pure tone averages at high frequencies (3,000, 4,000, and 6,000 Hz) for both ears. Additionally, the sleep duration was divided into quartiles. Odds ratios and 95% confidence intervals were estimated using multivariable logistic regression after adjusting for covariates.Results: The prevalence of presbycusis in South Korean adults was 62.1%, of which 61.4% showed moderate to severe presbycusis. The incidence of moderate-to-severe, but not mild, presbycusis showed a significant positive correlation with sleep duration.Conclusion: Our findings suggest that sleep duration is associated with the prevalence of presbycusis.

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WELSH, LOUIS W., JOHN J. WELSH e MICHAEL P. HEALY. "CENTRAL PRESBYCUSIS". Laryngoscope 95, n.º 2 (fevereiro de 1985): 128???136. http://dx.doi.org/10.1288/00005537-198502000-00002.

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Gates, George A. "Central Presbycusis". Otolaryngology–Head and Neck Surgery 147, n.º 1 (25 de abril de 2012): 1–2. http://dx.doi.org/10.1177/0194599812446282.

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Kang, Hee Jin, Dae Woong Kang, Sung Su Kim, Tong In Oh, Sang Hoon Kim e Seung Geun Yeo. "Analysis of Chronic Tinnitus in Noise-Induced Hearing Loss and Presbycusis". Journal of Clinical Medicine 10, n.º 8 (19 de abril de 2021): 1779. http://dx.doi.org/10.3390/jcm10081779.

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Introduction: The most frequent causes of tinnitus associated with hearing loss are noise-induced hearing loss and presbycusis. The mechanism of tinnitus is not yet clear, although several hypotheses have been suggested. Therefore, we aimed to analyze characteristics of chronic tinnitus between noise-induced hearing loss and presbycusis. Materials and Methods: This paper is a retrospective chart review and outpatient clinic-based study of 248 patients with chronic tinnitus from 2015 to 2020 with noise-induced or presbycusis. Pure tone audiometry (PTA), auditory brainstem response (ABR), distortion product otoacoustic emissions (DPOAE), transient evoked otoacoustic emissions (TEOAE), and tinnitograms were conducted. Results: PTA showed that hearing thresholds at all frequencies were higher in patients with noise-induced hearing loss than the presbycusis group. ABR tests showed that patients with presbycusis had longer wave I and III latencies (p < 0.05 each) than patients with noise-induced hearing loss. TEOAE tests showed lower values in patients with noise-induced hearing loss than presbycusis at 1.5, 2, 3, and 4 kHz (p < 0.05 each). DPOAE tests showed that response rates in both ears at 1.5, 2, and 3 kHz were significantly higher in patients with presbycusis than noise-induced hearing loss (p < 0.05 each). Discussion: This study showed that hearing thresholds were higher, the loudness of tinnitus was smaller, and the degree of damage to outer hair cells was lower in patients with presbycusis than with noise-induced hearing loss. Moreover, wave I and III latencies were more prolonged in patients with presbycusis despite their having lower hearing thresholds. These phenomena may reflect the effects of aging or degeneration of the central nervous system with age. Further studies are needed to evaluate the etiologies of tinnitus.

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Savitri, Eka, Indah Maulidah Haeruddin, Riskiana Djamin e Fajar Perkasa. "The Analysis of Presbycusis Type and Lesion Location Based on Audiogram Description, Speech Audiometry, and Otoaccoustic Emission". Open Access Macedonian Journal of Medical Sciences 10, B (14 de março de 2022): 793–96. http://dx.doi.org/10.3889/oamjms.2022.8507.

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Background: This study aims to determine the type of presbycusis and the location of the lesion based on audiogram images, speech audiometry and Otoacoustic Emission. Method: This study was an observational study of 36 presbycusis patients (72 ear samples). Pure tone audiometry, speech audiometry and Otoacoustic Emission were examined to determine the most types of presbycusis and the location of the lesion. A cross-sectional descriptive research method was conducted to analyze the dynamics of the correlation between risk factors and effects by using approaching, observing or collecting data at once (point time approach). Each research subject was observed only once, and measurements were performed towards the character status or subject variables during the examination. Result: The results showed that presbycusis was primarily obtained in the 60-69 years age group (69.4%). And the most types of presbycusis based on the audiogram were metabolic presbycusis (36.1%). The average hearing range based on the audiogram was at a frequency of 26-40 dB or the degree of mild deafness. Most types of deafness were Sensorineural Hearing Loss (SNHL). In speech audiometry, most NPT and NDT were mild and normal deafness as much as 44.4% in NPT and 56.9% in NDT. Based on the OAE, 72 samples showed the results of the referrals. In addition, regarding the results of the audiogram, speech audiometry and OAE, the location of the lesions of all samples were in the cochlea (100%). Conclusion: The most common type of presbycusis based on audiogram images is metabolic presbycusis with a mild hearing loss.

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Reis, Luis Roque, e Pedro Escada. "Effect of speechreading in presbycusis: Do we have a third ear?" Otolaryngologia Polska 71, n.º 6 (30 de dezembro de 2017): 38–44. http://dx.doi.org/10.5604/01.3001.0010.7196.

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Introduction: Evidence regarding the effect of speechreading is lacking in age-related hearing loss (presbycusis). Thus, in individuals with presbycusis, this study determined whether speechreading would improve word intelligibility. Moreover, the study investigated the effect of speechreading on word intelligibility depending on hearing impairment severity. Materials and methods: This analytical, cross-sectional study involved two groups of individuals aged > 65 years that were enrolled by convenience sampling: 29 individuals with bilateral sensorineural hearing loss compatible with presbycusis (n=58 ears; mean age, 74.1±9.4 years) and 10 controls with at-most-mild hearing loss (n=58 ears; mean age, 73.8±8.5 years). All participants underwent a comprehensive medical and audiological evaluation, which included speech audiometry with and without observation of the audiologist’s face, i.e. speechreading. Within each group, the effect of speechreading was determined as a change in the speech reception threshold. For all statistical analyses, p < 0.05 was considered significant. Results: Both in individuals with presbycusis and controls, speechreading significantly improved speech discrimination (p<.001<.05); however, compared to controls, this effect of speechreading on speech discrimination was more pronounced in individuals with presbycusis (p<.001). Discussion: Individuals with presbycusis or hearing impairment displayed improved spoken-word intelligibility when spoken-word recognition was coupled with speechreading. Thus, speechreading may serve as a “third ear”.

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Colucci, Dennis. "Central Presbycusis Counseling". Hearing Journal 71, n.º 4 (abril de 2018): 44. http://dx.doi.org/10.1097/01.hj.0000532400.06053.01.

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Lipkin, Mack, e Mark E. Williams. "Presbycusis and communication". Journal of General Internal Medicine 1, n.º 6 (novembro de 1986): 399–401. http://dx.doi.org/10.1007/bf02596426.

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Hu, Weiming, Junwu Wu, Wenjing Jiang e Jianguo Tang. "MicroRNAs and Presbycusis". Aging and Disease 9, n.º 1 (2018): 133. http://dx.doi.org/10.14336/ad.2017.0119.

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Chavant, Martin, e Zoï Kapoula. "Eye-Movement Deficits in Seniors with Hearing Aids: Cognitive and Multisensory Implications". Brain Sciences 12, n.º 11 (24 de outubro de 2022): 1425. http://dx.doi.org/10.3390/brainsci12111425.

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In recent years, there has been a growing body of literature highlighting the relationship between presbycusis and consequences in areas other than hearing. In particular, presbycusis is linked to depression, dementia, and cognitive decline. Among this literature, the effect of hearing aids, currently the most common method of treating presbycusis, is also a growing research topic. This pilot study aims to explore the effects of hearing aids on the cognitive and multisensory consequences of presbycusis. To that purpose, saccades and vergences eye movements were studied, towards visual and audiovisual targets, of a presbycusis population wearing hearing aids for an average of two years. These measurements were done whether or not participants were wearing their hearing aids. Eye-movement characteristics, particularly latencies (the reaction time taken to initiate an eye movement), allows one to measure attentional and multisensory characteristics. Previous studies showed that presbycusis was linked with an increase of saccade latencies and an improvement in audiovisual interaction capacities, i.e., latencies for audiovisual targets are shorter than those for visual targets. Eye movements are measured and analyzed with REMOBI and AIDEAL technologies. Results show a shortening, with hearing aids, of right saccade latencies to visual targets, suggesting an increase in attention and/or engagement. Yet, saccade latencies are not shorter for audiovisual vs. visual targets alone, neither when wearing hearing aids, nor without. Moreover, convergence latencies are particularly slow for any type of target and with or without hearing aids. The results suggest deficits for audiovisual interactions and the initiation of convergences in that population. These deficits could be part of the factors triggering the need to wear hearing aids. These results therefore show interesting relationships between hearing-aid wearing in a presbycusis population and oculomotricity and invite further research in this area.

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Nazarudin, Nurbaiti, Vania Nanda Priasty e Iwan Darmawan Ma’mur. "Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S)". ACTA Medical Health Sciences, Volume 1 No 2 (30 de outubro de 2022): 54–63. http://dx.doi.org/10.35990/amhs.v1n2_p54-63.

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Presbycusis is an age-related hearing loss caused by a degeneration process which is a cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of life in patients with hearing loss. This study aimed to determine the relationship between presbycusis with the quality of life. The research uses cross sectional analytical research methods. The data used in form of primary data is the result of filling in the guided questionnaire and the results of the audiogram, while secondary data is in the form of medical records of presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were similar between moderate and low economic status (49.1%), had a history of chronic diseases (76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a significant and strong relationship between presbycusis and patients’ quality of life (p <0.001) and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to degrees of decrease in quality of life.

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Nazarudin, Nurbaiti, Vania Nanda Priasty e Iwan Darmawan Ma’mur. "Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S)". ACTA Medical Health Sciences, Volume 1 No 2 (30 de outubro de 2022): 54–63. http://dx.doi.org/10.35990/amhs.v1n2.p54-63.

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Presbycusis is an age-related hearing loss caused by a degeneration process which is a cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of life in patients with hearing loss. This study aimed to determine the relationship between presbycusis with the quality of life. The research uses cross sectional analytical research methods. The data used in form of primary data is the result of filling in the guided questionnaire and the results of the audiogram, while secondary data is in the form of medical records of presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were similar between moderate and low economic status (49.1%), had a history of chronic diseases (76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a significant and strong relationship between presbycusis and patients’ quality of life (p <0.001) and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to degrees of decrease in quality of life.

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Nazarudin, Nurbaiti, Vania Nanda Priasty e Iwan Darmawan Ma’mur. "Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S)". ACTA Medical Health Sciences, Volume 1 No 2 (30 de outubro de 2022): 54–63. http://dx.doi.org/10.35990/amhs.v1n2.p54-63.

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Presbycusis is an age-related hearing loss caused by a degeneration process which is a cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of life in patients with hearing loss. This study aimed to determine the relationship between presbycusis with the quality of life. The research uses cross sectional analytical research methods. The data used in form of primary data is the result of filling in the guided questionnaire and the results of the audiogram, while secondary data is in the form of medical records of presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were similar between moderate and low economic status (49.1%), had a history of chronic diseases (76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a significant and strong relationship between presbycusis and patients’ quality of life (p <0.001) and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to degrees of decrease in quality of life.

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Rodrigues Dias, D., M. Santos, F. Sousa, S. Azevedo, S. Sousa e Castro, S. Freitas, C. Almeida e Sousa e Á. Moreira da Silva. "How do presbylarynx and presbycusis affect the Voice Handicap Index and the emotional status of the elderly? A prospective case–control study". Journal of Laryngology & Otology 135, n.º 12 (28 de setembro de 2021): 1051–56. http://dx.doi.org/10.1017/s0022215121002528.

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AbstractObjectiveTo assess the influence of presbylarynx and presbycusis on Voice Handicap Index and emotional status.MethodsA case–control, prospective, observational, cross-sectional study was conducted of patients aged 65 years or older referred to an otorhinolaryngology department from January to September 2020. Presbycusis was assessed by pure tone and vocal audiometry. Each subject underwent fibre-optic videolaryngoscopy with stroboscopy, and presbylarynx was considered when two or more of the following endoscopic findings were identified: vocal fold bowing, prominence of vocal processes in abduction, and a spindle-shaped glottal gap. Each subject completed two questionnaires: Voice Handicap Index and Geriatric Depression Scale (short-form).ResultsThe studied population included 174 White European subjects, with a mean age of 73.99 years, of whom 22.8 per cent presented both presbylarynx and presbycusis. Multivariate linear regression revealed that only presence and severity of presbylarynx had an influence on Voice Handicap Index-30 scores. However, both spindle-shaped glottal gap and presbycusis influenced Geriatric Depression Scale scores.ConclusionPresbylarynx has a strong association with the impact of voice on quality of life. Presbylarynx and presbycusis seem to have a cumulative effect on emotional status.

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Dong, Yang, Yue Ding, Pu-Zhao Liu, Hai-Yan Song, Yu-Ping Zhao, Ming Li e Jian-Rong Shi. "Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GC/MS Metabolomics". Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/762092.

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Objective. To investigate the correlation between presbycusis and kidney deficiency as defined by traditional Chinese medicine (TCM) and its material basis from the perspective of metabolism.Methods. Pure-tone audiometry was used to test auditory function. A kidney deficiency symptom scoring table was used to measure the kidney deficiency accumulated scores of the research subjects. Gas chromatography/mass spectrometry (GC/MS) was used to measure the metabolites in the urine samples from 11 presbycusis patients and 9 elderly people with normal hearing.Results. Hearing loss in the elderly was positively correlated with kidney deficiency score in TCM. There were significant differences in urine metabolite profile between the presbycusis patients and the controls. A total of 23 differentially expressed metabolites were found. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these metabolites were related to glutathione metabolism, amino acid metabolism, glucose metabolism, theN-methyl-D-aspartic acid (NMDA) receptor pathway, and theγ-aminobutyric acid (GABA) receptor pathway.Conclusion. Glutathione metabolism, amino acid metabolism, glucose metabolism, NMDA receptors, and GABA receptors may be related to the pathogenesis of presbycusis and may be the material basis underlying the correlation between presbycusis and kidney deficiency in TCM.

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Boucher, Sophie, Fabienne Wong Jun Tai, Sedigheh Delmaghani, Andrea Lelli, Amrit Singh-Estivalet, Typhaine Dupont, Magali Niasme-Grare et al. "Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis". Proceedings of the National Academy of Sciences 117, n.º 49 (23 de novembro de 2020): 31278–89. http://dx.doi.org/10.1073/pnas.2010782117.

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Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half the phenotypic variance has been attributed to genetic factors. Here, we assessed the contribution to presbycusis of ultrarare pathogenic variants, considered indicative of Mendelian forms. We focused on severe presbycusis without environmental or comorbidity risk factors and studied multiplex family age-related hearing loss (mARHL) and simplex/sporadic age-related hearing loss (sARHL) cases and controls with normal hearing by whole-exome sequencing. Ultrarare variants (allele frequency [AF] < 0.0001) of 35 genes responsible for autosomal dominant early-onset forms of deafness, predicted to be pathogenic, were detected in 25.7% of mARHL and 22.7% of sARHL cases vs. 7.5% of controls (P= 0.001); half were previously unknown (AF < 0.000002).MYO6,MYO7A,PTPRQ, andTECTAvariants were present in 8.9% of ARHL cases but less than 1% of controls. Evidence for a causal role of variants in presbycusis was provided by pathogenicity prediction programs, documented haploinsufficiency, three-dimensional structure/function analyses, cell biology experiments, and reported early effects. We also establishedTmc1N321I/+mice, carrying theTMC1:p.(Asn327Ile) variant detected in an mARHL case, as a mouse model for a monogenic form of presbycusis. Deafness gene variants can thus result in a continuum of auditory phenotypes. Our findings demonstrate that the genetics of presbycusis is shaped by not only well-studied polygenic risk factors of small effect size revealed by common variants but also, ultrarare variants likely resulting in monogenic forms, thereby paving the way for treatment with emerging inner ear gene therapy.

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Chester, Jacqueline, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic et al. "A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology". Pharmaceutics 13, n.º 7 (8 de julho de 2021): 1041. http://dx.doi.org/10.3390/pharmaceutics13071041.

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Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in five people over 50 years of age, and this prevalence is growing annually. Associations have emerged between presbycusis and detrimental health outcomes, including social isolation and mental health. It remains largely untreatable apart from hearing aids, and with no globally established prevention strategies in the clinical setting. Hence, this review aims to explore the pathophysiology of presbycusis and potential therapies, based on a recent advancement in bile acid-based bio-nanotechnologies. A comprehensive online search was carried out using the following keywords: presbycusis, drugs, hearing loss, bile acids, nanotechnology, and more than 150 publications were considered directly relevant. Evidence of the multifaceted oxidative stress and chronic inflammation involvement in cellular damage and apoptosis that is associated with a loss of hair cells, damaged and inflamed stria vascularis, and neuronal signalling loss and apoptosis continues to emerge. New robust and effective therapies require drug delivery deeper into the various layers of the cochlea. Bile acid-based nanotechnology has gained wide interest in its permeation-enhancing ability and potential for numerous applications in treating presbycusis.

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Chavant, Martin, e Zoï Kapoula. "Presbycusis and the Aging of Eye Movement: Common Attention Mechanisms". Brain Sciences 12, n.º 1 (13 de janeiro de 2022): 107. http://dx.doi.org/10.3390/brainsci12010107.

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Presbycusis, physiological age-related hearing loss, is a major health problem because it is the most common cause of hearing impairment, and its impact will grow in the coming years with the aging population. Besides auditory consequences, the literature recently found an association between hearing loss and cognitive decline over the last two decades, emphasizing the importance of the early detection of presbycusis. However, the current hearing tests are not sufficient to detect presbycusis in some cases. Furthermore, the underlying mechanisms of this association are still under discussion, calling for a new field of research on that topic. In that context, this study investigates for the first time the interaction between presbycusis, eye movement latency and Stroop scores for a normal aging population. Hearing abilities, eye movement latency and the Stroop Victoria test were measured for 69 elderly (mean 66.7 ± 8.4) and 30 young (mean 25.3 ± 2.7) participants. The results indicated a significant relationship between saccade latency and speech audiometry in the silence score, independently from age. These promising results suggest common attentional mechanisms between speech processing and saccade latency. The results are discussed regarding the relationship between hearing and cognition, and regarding the perspective of expanding new tools for presbycusis diagnosis.

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Ciorba, A., A. Benatti, C. Bianchini, C. Aimoni, S. Volpato, R. Bovo e A. Martini. "High frequency hearing loss in the elderly: effect of age and noise exposure in an Italian group". Journal of Laryngology & Otology 125, n.º 8 (10 de junho de 2011): 776–80. http://dx.doi.org/10.1017/s0022215111001101.

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AbstractObjective:To describe the effect of age and noise on high frequency hearing thresholds in an Italian population aged 70 years and older, in order to investigate the interaction between presbycusis and noise exposure.Methods:We compared 460 subjects: 367 affected by presbycusis alone (204 women and 163 men) and 93 affected by presbycusis and noise exposure (eight women and 85 men). Pure tone average hearing thresholds, for each ear, were compared between groups, and between sexes and ages within groups.Results:A slight threshold difference was found between the two groups at 4 kHz. After adjusting for age and gender, this difference was found to be related only to differing patient age. Men's and women's thresholds differed significantly in both groups, especially at high frequencies, at which threshold deterioration was worse in men than women.Conclusion:The threshold differences between patients with presbycusis with and without noise exposure were limited. Larger studies are needed to assess the relative effects of ageing and noise exposure on hearing thresholds.

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Hasansulama, Wijana, Teti Madiadipoera, Sunarjati Sunarjati e Herry Garna. "Glutathione Peroxide and Glutathione to Disulfide Glutathione Ratio in Presbycusis: a Case-control Study". Medical Archives 76, n.º 3 (2022): 209. http://dx.doi.org/10.5455/medarh.2022.76.209-214.

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Background: Presbycusis is a gradual hearing loss caused by the ageing process. This is a chronic condition that affects the elderly population, and sensorineural progressive bilateral symmetry occurs with predominantly high-frequency hearing loss. The ability to discriminate speech decreases; hence, most of the affected patients have conversation problems, especially in noisy environments.This situation is a serious problem among elderly individuals. Social isolation, depression, and paranoia can be related to presbycusis. Objective: The aim of this study was to investigate GPx and the GSH:GSSG ratio as risk factors for presbycusis. Methods: A case-control study was conducted to determine the role of GPx activity with the GSH:GSSG ratio as a presbycusis risk factor in 60 subjects aged 55 to 75 years old during the period of August 2012 - April 2014. All of the subjects passed an ENT examination, pure tone audiometry, and tympanometry. The activity of GPx was measured with the Paglia and Valentine method, and the GSH:GSSG ratio was measured by the calorimetric method. Results: The activity of GPx and the GSH:GSSG ratio were significantly different between the groups (p<0.05), and the odds ratio for high GPx with a low GSH:GSSG ratio was 135 (CI 95%: 5.17–20,028.88). Conclusion: High GPx activity with a low GSH:GSSG ratio is a risk factor for presbycusis.

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Ballivet de Régloix, Stanislas, Louise Genestier, Olga Maurin, Salome Marty, Anna Crambert e Yoann Pons. "Presbycusis and Fitness to Fly". Aerospace Medicine and Human Performance 91, n.º 5 (1 de maio de 2020): 403–8. http://dx.doi.org/10.3357/amhp.5510.2020.

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BACKGROUND: When a pilot is referred for presbycusis, his flight fitness may be questionable. The objective of this retrospective study was to describe a case series of presbycusis in a pilot population and to discuss the decisions about their flight waivers.METHODS: There were 19 pilots who were referred to the ENT-Head and Neck Surgery Department of the National Pilot Expertise Center. Their medical files were retrospectively examined.RESULTS: Of the 19 patients, 5 did not obtain flight fitness waivers. Among the 14 who received waivers, 7 had no restrictions on their flight fitness.DISCUSSION: Flight fitness was based on the maximum percentage of speech recognition and the slope of the curve for speech recognition in speech audiometry in noise and the follow-up of these findings. The results made it possible to determine a patient’s fitness to fly with a waiver, which may be associated with restrictions. In our series, only 5 pilots out of 19 did not obtain a flight fitness waiver. The few published studies on the resumption of flight for patients who had presbycusis and our experience in France with similar waivers in commercial and military aviation suggest that under certain conditions and after relevant cochlear assessment, presbycusis may allow for a safe pursuit of aviation activity.Ballivet de Régloix S, Genestier L, Maurin O, Marty S, Crambert A, Pons Y. Presbycusis and fitness to fly. Aerosp Med Hum Perform. 2020; 91(5):403–408.

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Notoya, Masako. "Presbycusis and Auditory agnosia". Higher Brain Function Research 38, n.º 2 (30 de junho de 2018): 216–21. http://dx.doi.org/10.2496/hbfr.38.216.

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Demeester, Kelly, Astrid van Wieringen, Jan-jaap Hendrickx, Vedat Topsakal, Erik Fransen, Lut van Laer, Guy Van Camp e Paul Van de Heyning. "Audiometric shape and presbycusis". International Journal of Audiology 48, n.º 4 (janeiro de 2009): 222–32. http://dx.doi.org/10.1080/14992020802441799.

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Rizk, Habib Georges, e Fred H. Linthicum. "Histopathologic Categorization of Presbycusis". Otology & Neurotology 33, n.º 3 (abril de 2012): e23-e24. http://dx.doi.org/10.1097/mao.0b013e31821f84ee.

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Thobaben, Marshelle. "Helping clients with presbycusis". Home Care Provider 3, n.º 4 (agosto de 1998): 186–88. http://dx.doi.org/10.1016/s1084-628x(98)90123-x.

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Arlinger, Stig. "Audiometric profile in presbycusis". Acta Oto-Laryngologica 111, sup476 (janeiro de 1991): 85–90. http://dx.doi.org/10.3109/00016489109127259.

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Ko, JungYung. "Presbycusis and its management". British Journal of Nursing 19, n.º 3 (11 de janeiro de 2010): 160–65. http://dx.doi.org/10.12968/bjon.2010.19.3.46536.

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Thalmann, Isolde, Kuniaki Takahashi e Ruediger Thalmann. "Biochemical considerations in presbycusis". Journal of the Acoustical Society of America 84, S1 (novembro de 1988): S53—S54. http://dx.doi.org/10.1121/1.2026360.

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Parham, Kourosh, e Karen M. Kost. "Presbycusis—Peripheral and Central". Ear, Nose & Throat Journal 96, n.º 12 (dezembro de 2017): 462–63. http://dx.doi.org/10.1177/014556131709601206.

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Parham, Kourosh, Frank R. Lin, Daniel H. Coelho, Robert T. Sataloff e George A. Gates. "Comprehensive Management of Presbycusis". Otolaryngology–Head and Neck Surgery 148, n.º 4 (8 de fevereiro de 2013): 537–39. http://dx.doi.org/10.1177/0194599813477596.

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McKinnon, Brian J., George A. Gates, Douglas D. Backous e Howard W. Francis. "Auditory Neurology: Understanding Presbycusis". Otolaryngology–Head and Neck Surgery 149, n.º 2_suppl (23 de agosto de 2013): P23—P24. http://dx.doi.org/10.1177/0194599813493390a58.

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Chavant, Martin, e Zoï Kapoula. "Audiovisual Integration for Saccade and Vergence Eye Movements Increases with Presbycusis and Loss of Selective Attention on the Stroop Test". Brain Sciences 12, n.º 5 (3 de maio de 2022): 591. http://dx.doi.org/10.3390/brainsci12050591.

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Multisensory integration is a capacity allowing us to merge information from different sensory modalities in order to improve the salience of the signal. Audiovisual integration is one of the most used kinds of multisensory integration, as vision and hearing are two senses used very frequently in humans. However, the literature regarding age-related hearing loss (presbycusis) on audiovisual integration abilities is almost nonexistent, despite the growing prevalence of presbycusis in the population. In that context, the study aims to assess the relationship between presbycusis and audiovisual integration using tests of saccade and vergence eye movements to visual vs. audiovisual targets, with a pure tone as an auditory signal. Tests were run with the REMOBI and AIDEAL technologies coupled with the pupil core eye tracker. Hearing abilities, eye movement characteristics (latency, peak velocity, average velocity, amplitude) for saccade and vergence eye movements, and the Stroop Victoria test were measured in 69 elderly and 30 young participants. The results indicated (i) a dual pattern of aging effect on audiovisual integration for convergence (a decrease in the aged group relative to the young one, but an increase with age within the elderly group) and (ii) an improvement of audiovisual integration for saccades for people with presbycusis associated with lower scores of selective attention in the Stroop test, regardless of age. These results bring new insight on an unknown topic, that of audio visuomotor integration in normal aging and in presbycusis. They highlight the potential interest of using eye movement targets in the 3D space and pure tone sound to objectively evaluate audio visuomotor integration capacities.

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Gürkan, Selhan, Serpil Mungan Durankaya, Başak Mutlu, Yalçın İşler, Yiğit Ö. Uzun, Oğuz Başokçu, Taner Kemal Erdağ e Günay Kırkım. "Comparison of Cortical Auditory Evoked Potential Findings in Presbycusis with Low and High Word Recognition Score". Journal of the American Academy of Audiology 31, n.º 06 (junho de 2020): 442–48. http://dx.doi.org/10.3766/jaaa.19063.

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Abstract Background Deteriorated speech understanding is a common complaint in elderly people, and behavioral tests are used for routine clinical assessment of this problem. Cortical auditory evoked potentials (CAEPs) are frequently used for assessing speech detection and discrimination abilities of the elderly, and give promise for differential diagnosis of speech understanding problems. Purpose The aim of the study was to compare the P1, N1, and P2 CAEP latencies and amplitudes in presbycusis with low and high word recognition score (WRS). Research Design A cross-sectional study design was used forthe study. Two groups were formed from the patients with presbycusis based on their scores on the speech recognition test. Study Sample Fifty-seven elderly volunteers participated in the study. The first group composed of 27 participants with high WRS, the other group composed of 30 participants with low WRS. Data Collection and Analysis The CAEP waves were recorded from these participants using speech signals. Latencies and amplitudes of P1 -N1-P2 waves of the two groups were compared with the f-test statistic. Results There were significant prolongation of P1 and N1 latencies in presbycusis with low WRS when compared with presbycusis with a relatively high word score (p < 0.05). Conclusion According to the result of the research, P1 and N1 latencies of presbycusis with low WRS were longer than the participants with high WRS. Factors affecting peripheral auditory system, such as stimulus sensation level, might be responsible for P1 and N1 latency prolongation of the low WRS group.

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Chan, Zoe Yee Ting, e Bradley McPherson. "Over-the-Counter Hearing Aids: A Lost Decade for Change". BioMed Research International 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/827463.

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Background. Hearing aids sold directly to consumers in retail stores or through the internet, without individual prescription by audiological professionals, are termed over-the-counter (OTC) devices. This study aimed to determine whether there was any change in the electroacoustic characteristics of OTC devices compared to research carried out a decade earlier. The previous results indicated that most OTC devices were low-frequency-emphasis devices and were unsuitable for elderly people with presbycusis, who were likely to be the major consumers of these products.Methods. Ten OTC devices were selected and their electroacoustic performance was measured. Appropriate clients for the OTC devices were derived, using four linear prescription formulae, and OTC suitability for elderly persons with presbycusis was investigated.Results. OTC electroacoustic characteristics were similar to those in the earlier study. Most OTC devices were not acoustically appropriate for potential consumers with presbycusis. Although several of the devices could match prescriptive targets for individuals with presbycusis, their poor electroacoustic performance—including ineffective volume control function, high equivalent input noise, and irregular frequency response—may override their potential benefit.Conclusion. The low-cost OTC devices were generally not suitable for the main consumers of these products, and there has been little improvement in the appropriateness of these devices over the past decade.

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Chen, Zhe, Yanmei Zhang, Junbo Zhang, Rui Zhou, Zhen Zhong, Chaogang Wei, Jing Chen e Yuhe Liu. "Cochlear Synaptopathy: A Primary Factor Affecting Speech Recognition Performance in Presbycusis". BioMed Research International 2021 (6 de agosto de 2021): 1–7. http://dx.doi.org/10.1155/2021/6667531.

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The results of recent animal studies have suggested that cochlear synaptopathy may be an important factor involved in presbycusis. Therefore, here, we aimed to examine whether cochlear synaptopathy frequently exists in patients with presbycusis and to describe the effect of cochlear synaptopathy on speech recognition in noise. Based on the medical history and an audiological examination, 94 elderly patients with bilateral, symmetrical, sensorineural hearing loss were diagnosed as presbycusis. An electrocochleogram, auditory brainstem responses, auditory cortical evoked potentials, and speech audiometry were recorded to access the function of the auditory pathway. First, 65 ears with hearing levels of 41-50 dB HL were grouped based on the summating potential/action potential (SP/AP) ratio, and the amplitudes of AP and SP were compared between the two resulting groups. Second, 188 ears were divided into two groups: the normal SP/AP and abnormal SP/AP groups. The speech recognition abilities in the two groups were compared. Finally, the relationship between abnormal electrocochleogram and poor speech recognition (signal-to-noise ratio loss ≥7 dB) was analyzed in 188 ears. The results of the present study showed: (1) a remarkable reduction in the action potential amplitude was observed in patients with abnormal SP/AP ratios; this suggests that cochlear synaptopathy was involved in presbycusis. (2) There was a large proportion of patients with poor speech recognition in the abnormal SP/AP group. Furthermore, a larger number of cases with abnormal SP/AP ratios were confirmed among patients with presbycusis and poor speech recognition. We concluded that cochlear synaptopathy is not uncommon among elderly individuals who have hearing ability deficits, and it may have a more pronounced effect on ears with declining auditory performance in noisy environments.

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Heman-Ackah, Selena E., Tina C. Huang e Steven K. Juhn. "R442 – Antioxidant Therapy Prevents Presbycusis In C57BL6 mice". Otolaryngology–Head and Neck Surgery 139, n.º 2_suppl (agosto de 2008): P192. http://dx.doi.org/10.1016/j.otohns.2008.05.598.

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Problem Presbycusis, or age-related hearing loss, is characterized by gradual, progressive sensorineural hearing loss which accompanies aging with associated decreased speech recognition in noisy environments, slowed central processing of acoustic stimuli and impaired sound localization. In addition to impairing one's ability to communicate effectively, presbycusis jeopardizes one's autonomy, presents a safety concern and has been correlated with an increased incidence of clinical depression and social withdrawal. By 2025, it is estimated that approximately 25 million Americans will be affected, thus this presents a major public health concern. The purpose of this study is to evaluate the potential of antioxidant therapy, including two novel antioxidants, in the prevention of presbycusis. Methods C57BL6 mice were assigned to treatment or control groups. Treatment groups of mice were fed with a combination of two novel antioxidants, L-cysteine-glutathione mixed disulfide and ribose cysteine, as well as vitamin B12, folic acid, and ascorbic acid. Auditory brainstem response thresholds were recorded at baseline and on a monthly basis following initiation of treatment. Results Threshold shifts were observed according to the established pattern of age related loss associated with C57BL6 mice. Threshold shifts were decreased in the treatment group. Statistically significant differences (p<0.001) in threshold shifts were observed between the treatment and control groups for click stimulus and pure tones at 4, 8, 12, 16 and 32 kHz. The treatment group was found to have a smaller degree of shift in association with aging. Conclusion Combination antioxidant therapy effectively decreased threshold shifts on auditory brainstem responses within the established animal model for presbycusis. Significance Combination antioxidant therapy may prove a safe and cost-effective method of preventing presbycusis in our growing elderly population. Support American Academy of Otolaryngology – Head and Neck Surgery Foundation Resident Research Grant.

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Azeez, Refad A. "Presbycusis and hyperlipidemia: Is there any link?" Muthanna Medical Journal 7, n.º 2 (12 de dezembro de 2020): 47–57. http://dx.doi.org/10.52113/1/7.2/20.47.

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Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teaching Hospital from March 2019 to December 2019. A cross‑sectional study on 52 patients with Hyperlipidemia and 42 non Hyperlipidemic patients was carried out during March 2019 to December 2019. All patients were evaluated for hearing loss by subjecting to pure tone audiometry, blood investigations were done in form of lipid profile, blood sugars, thyroid function test, blood urea and serum creatinine levels. Group A consisted of 22 (42.3%) males and 30 (57.7%) female while group B consisted of 23 (54.8%) male and 19 (45.2%) female individuals. Audiological assessment by PTA was show that the prevalence of presbycusis among hyperlipidemic group more than non hyperlipidemic with significant statistical difference (P value <0.05). Prevalence was 76.9%. In conclusion; there is statistically significant association between presbycusis and hyperlipidemia especially those with hyercholestrolemia.

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Azeez, Refad Abdul, Ahmed Al Ansary e BThenoon Yasin. "Presbycusis and hyperlipidemia: Is there any link?" Muthanna Medical Journal 7, n.º 2 (19 de dezembro de 2020): 49–57. http://dx.doi.org/10.52113/1/7.2/2020.57.

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"Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teaching Hospital from March 2019 to December 2019. A cross‑sectional study on 52 patients with Hyperlipidemia and 42 non Hyperlipidemic patients was carried out during March 2019 to December 2019. All patients were evaluated for hearing loss by subjecting to pure tone audiometry, blood investigations were done in form of lipid profile, blood sugars, thyroid function test, blood urea and serum creatinine levels. Group A consisted of 22 (42.3%) males and 30 (57.7%) female while group B consisted of 23 (54.8%) male and 19 (45.2%) female individuals. Audiological assessment by PTA was show that the prevalence of presbycusis among hyperlipidemic group more than non hyperlipidemic with significant statistical difference (P value <0.05). Prevalence was 76.9%. In conclusion; there is statistically significant association between presbycusis and hyperlipidemia especially those with hyercholestrolemia.

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Safitri, Maisara, Eva Nurfarihah e Mitra Handini. "Kualitas Hidup Penderita Presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Pontianak tahun 2019". Cermin Dunia Kedokteran 49, n.º 1 (3 de janeiro de 2022): 5–9. http://dx.doi.org/10.55175/cdk.v49i1.178.

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Prevalensi presbikusis sebesar 30-35% di antara orang berusia 65-75 tahun di Indonesia. Presbikusis mengganggu komunikasi dan memengaruhi kualitas hidup penderitanya. Tujuan penelitian ini untuk mengetahui hubungan antara gangguan pendengaran dan kualitas hidup penderita presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Kota Pontianak. Penelitian analitik dilakukan dengan pendekatan potong lintang. Subjek penelitian berjumlah 39 orang. Kualitas hidup pada penelitian ini diukur dengan kuesioner HHIE-S (Hearing Handicap Inventory for the Elderly-Screening). Analisis data dengan uji Kendall’s tau c menunjukkan p value = 0,0000 dan nilai korelasi sebesar 0,675. Terdapat korelasi kuat antara gangguan pendengaran dan kualitas hidup penderita presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Pontianak tahun 2019. The prevalence of presbycusis among 65-75 year-olds in Indonesia is 30-35%. Presbycusis will reduce their communication ability and impact their quality of life. This study aimed to determine the correlation between degree of hearing loss and quality of life among presbycusis patients at RSUD Sultan Syarif Mohamad Alkadrie. Thirty nine subjects were included in this analytical cross-sectional study. The quality of life was measured using the HHIE-S (Hearing Handicap Inventory for the Elderly-Screening) questionnaire. Kendall’s tau c analysis resulted in p value = 0.0000 and correlation coefficient was 0.675. Severity of hearing loss is strongly related to quality of life among presbycusis patients at RSUD Sultan Syarif Mohamad Alkadrie in Pontianak in 2019.

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Parham, Kourosh, Brian J. McKinnon, David Eibling e George A. Gates. "Challenges and Opportunities in Presbycusis". Otolaryngology–Head and Neck Surgery 144, n.º 4 (10 de fevereiro de 2011): 491–95. http://dx.doi.org/10.1177/0194599810395079.

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Colucci, Dennis A. "The Dilemma of Central Presbycusis". Hearing Journal 67, n.º 4 (abril de 2014): 48. http://dx.doi.org/10.1097/01.hj.0000446438.42386.a8.

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Ciorba, A., S. Hatzopoulos, C. Bianchini, C. Aimoni, H. Skarzynski e PH Skarzynski. "Genetics of presbycusis and presbystasis". International Journal of Immunopathology and Pharmacology 28, n.º 1 (março de 2015): 29–35. http://dx.doi.org/10.1177/0394632015570819.

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Parham, Kourosh, George Gates, Robert Dobie, Brian McKinnon e Douglas Backous. "Challenges and Opportunities in Presbycusis". Otolaryngology–Head and Neck Surgery 143, n.º 2_suppl (agosto de 2010): P31. http://dx.doi.org/10.1016/j.otohns.2010.06.674.

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Kocher, Carl A. "Presbycusis: Reversible with anesthesia drugs?" Medical Hypotheses 72, n.º 2 (fevereiro de 2009): 157–59. http://dx.doi.org/10.1016/j.mehy.2008.09.013.

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