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Braun, Burkhard R., W. Steven Head, Ming X. Wang e Alexander D. Johnson. "Identification and Characterization of TUP1-Regulated Genes in Candida albicans". Genetics 156, n.º 1 (1 de setembro de 2000): 31–44. http://dx.doi.org/10.1093/genetics/156.1.31.
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Abstract TUP1 encodes a transcriptional repressor that negatively controls filamentous growth in Candida albicans. Using subtractive hybridization, we identified six genes, termed repressed by TUP1 (RBT), whose expression is regulated by TUP1. One of the genes (HWP1) has previously been characterized, and a seventh TUP1-repressed gene (WAP1) was recovered due to its high similarity to RBT5. These genes all encode secreted or cell surface proteins, and four out of the seven (HWP1, RBT1, RBT5, and WAP1) encode putatively GPI-modified cell wall proteins. The remaining three, RBT2, RBT4, and RBT7, encode, respectively, an apparent ferric reductase, a plant pathogenesis-related protein (PR-1), and a putative secreted RNase T2. The expression of RBT1, RBT4, RBT5, HWP1, and WAP1 was induced in wild-type cells during the switch from the yeast form to filamentous growth, indicating the importance of TUP1 in regulating this process and implicating the RBTs in hyphal-specific functions. We produced knockout strains in C. albicans for RBT1, RBT2, RBT4, RBT5, and WAP1 and detected no phenotypes on several laboratory media. However, two animal models for C. albicans infection, a rabbit cornea model and a mouse systemic infection model, revealed that rbt1Δ and rbt4Δ strains had significantly reduced virulence. TUP1 appears, therefore, to regulate many genes in C. albicans, a significant fraction of which are induced during filamentous growth, and some of which participate in pathogenesis.
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Fujishiro, Noriko, Shuichi Mitsunaga, Akira Shinohara, Misaki K. Takeno, Hideki Funazaki, Gen Kimura, Kazuo Watanabe et al. "Frequency of severe neutropenia occurring as an adverse events of gemcitabine plus cisplatin chemotherapy in patients with recurrent biliary tract cancer compared to those with unresectable biliary tract cancer." Journal of Clinical Oncology 35, n.º 4_suppl (1 de fevereiro de 2017): 488. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.488.
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488 Background: In patients (pts) with biliary tract cancer (BTC), relapse occurs at a high frequency even after curative resection. It remains unclear whether in pts with postoperative recurrence receiving chemotherapy, the surgery exerts any influence on the risk of development of toxicities. The aim of this study was to compare the outcomes and incidences of adverse events between recurrent BTC (rBTC) pts and unresectable BTC (uBTC) pts receiving gemcitabine plus cisplatin chemotherapy (GC). Methods: Data of pts with rBTC or uBTC receiving GC as the first-line chemotherapy were analyzed. The GC regimen consisted of gemcitabine 1000 mg/m2 plus cisplatin 25 mg/m2on days 1 and 8, administered every 3 weeks. All adverse events occurring during the first 180 days of GC were evaluated according to CTCAE, version 4.0. Results: A total of 151 pts, including 55 pts with rBTC and 96 pts with uBTC, were enrolled. In regard to the baseline characteristics, no significant differences between the rBTC and uBTC groups were found in the gender distribution [male: 69% vs. 57%], age [median: 68 vs. 68], or ECOG performance status (PS) [PS0: 67%vs. 55%]. The distribution of the primary tumor site (intrahepatic bile duct [27% vs. 33%] / extrahepatic bile duct [45% vs. 20%] / gallbladder [20% vs. 44%] / ampulla [7% vs. 3%]) was unbalanced between the two groups ( p < 0.01). The overall survival (OS) was significantly longer in the rBTC group than that in the uBTC group [median 15.8 months vs. 10.0 months, p = 0.02], however, there was no significant difference in the progression-free survival [median 6.8 months vs. 5.8 months] between the two groups. Grade 3-4 neutropenia was more frequent in the rBTC group [69%] as compared to that in the uBTC group [44%, p < 0.01], whereas Grade 3-4 cholangitis was significantly less frequent in the rBTC [5%] group than that in the uBTC group [21%, p = 0.02]. Conclusions: The incidence of Grade 3-4 neutropenia developing during GC was significantly higher in the rBTC group as compared to that in the uBTC group.
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Canales-Rodríguez, Citlalin, Ana Paola Martínez-Falcón, Alfredo Ramírez-Hernández e Aurelio Ramírez-Bautista. "Diversidad de Copestylum Macquart, 1846 (Diptera: Syrphidae) asociados a cactáceas (Cactaceae Juss, 1789) en descomposición en dos Reservas de la Biosfera de México central". Cuadernos de Biodiversidad, n.º 60 (4 de fevereiro de 2021): 1. http://dx.doi.org/10.14198/cdbio.2021.60.01.
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El conocimiento de la biodiversidad de los sírfidos (Diptera: Syrphidae) en las zonas semiáridas de México, es muy limitado, sobre todo, al relacionado con las cactáceas en descomposición. Este estudio aporta un inventario faunístico de los sírfidos del género Copestylum asociados a los tejidos en descomposición de los cactus de matorrales crasicaules en dos Reservas de la Biosfera, “Barranca de Metztitlán” (RBBM) y “Tehuacán-Cuicatlán” (RBTC), ambas situadas en el centro de México. Se analiza la diversidad y composición de especies de sírfidos en ambas reservas y se documenta la especie de cactus a la que se asocian las larvas de estos dípteros durante la época de lluvias. El método de recolecta fue mediante búsqueda directa de estados inmaduros que se desarrollan en tejidos de cactáceas en descomposición. Se obtuvieron 137 ejemplares de sírfidos pertenecientes a 10 especies entre las dos reservas estudiadas. Los resultados indican que no existen diferencias significativas en la riqueza de especies entre ambas reservas, pero sí hay diferencia al comparar la diversidad de orden q2. En la RBBM, la especie dominante fue Copestylum latum, mientras que Copestylum posticum fue la especie dominante en la RBTC. La especie de cactus determina la segregación de sírfidos en cada reserva. En la RBBM, las especies de sírfidos se asociaron a las especies de cactus Isolatocereus dumortieri y Myrtillocactus geometrizans, mientras que, en la RBTC fueron Neobuxbaumia mezcalensis, Pachycereus hollianus y Myrtillocactus geometrizans.
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Arendt, Łukasz. "Czy polski rynek pracy zmierza ku polaryzacji?" Olsztyn Economic Journal 13, n.º 3 (26 de junho de 2018): 309–22. http://dx.doi.org/10.31648/oej.2755.
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W artykule podjęto problematykę charakteru zmiany technologicznej na polskim rynku pracy, skupiając się na dwóch dominujących obecnie w literaturze przedmiotu koncepcjach: zmiany technologicznej faworyzującej wysokie kwalifikacje (SBTC) i postępu technicznego ukierunkowanego na rutynizację (RBTC). Celem była weryfikacja hipotezy o polaryzacji polskiego rynku pracy. W przedstawionej w artykule analizie empirycznej wykazano, że zmiany na polskim rynku pracy odbiegają od ścieżki polaryzacji charakterystycznej dla krajów rozwiniętych. Okazuje się bowiem, że największy spadek popytu na pracę nie wystąpił w grupach zawodów zlokalizowanych w środkowej części rozkładu kwalifikacji/płac. Zmiana technologiczna spowodowała ogólny wzrost zapotrzebowania na wysokie kwalifikacje, jednocześnie zatrudnienie i płace w grupie pracowników o niskich kwalifikacjach istotnie się nie pogorszyły. Doszło również do znacznych zmian w strukturze zadań wykonywanych na poszczególnych stanowiskach pracy. Kierunek tych zmian jest podobny do trendów zidentyfikowanych w krajach rozwiniętych, z wyjątkiem popytu na rutynowe zadania kognitywne, na które w Polsce w ciągu ostatniej dekady zapotrzebowanie wzrosło. Wyniki analizy są niejednoznaczne - zmiany w strukturze zatrudnienia i wynagrodzeń w Polsce lokują się między scenariuszami wynikającymi z hipotez SBTC i RBTC.
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Ramírez-López, Xareni, Carlos Ramírez-Herrera, Mario V. Velasco-García e Víctor M. Cetina-Alcalá. "Population structure and spatial distribution of oregano (Lippia graveolensH. B. K.) at the Tehuacán-Cuicatlán Biosphere Reserve, Mexico". Revista Chapingo Serie Ciencias Forestales y del Ambiente 28, n.º 2 (30 de abril de 2022): 289–303. http://dx.doi.org/10.5154/r.rchscfa.2021.04.024.
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Introduction:Oregano (Lippia graveolens H. B. K.) grows in semi-arid ecosystems. There is no information on the population dynamics of this species at the Tehuacán-Cuicatlán Biosphere Reserve (RBTC). Objective: To determine the vertical structure and spatial distribution of L. graveolens in five topographic conditions in the RBTC. Materials and methods: Ten sampling units were established in five topographic conditions (TC), where six plant height categories were defined. Density and structural variables were measured, from which IVI was obtained and population structure curves were constructed. The spatial distribution pattern was analyzed with the Ripley’s transformed function (L(t)). Results and discussion: TC1 showed population curve type IV (low frequency in the first, third and fourth height categories, high in the second and fifth categories, and low in the rest) with lower density (100 plants∙ha-1; 1.6 %) in category 6 (>251 cm), and higher density (1 840 plants∙ha-1;29 %) in category 4 (151 a 200 cm). For TC2 to TC5, the curve was V-type (low frequency in the first category, gradual increase up to the intermediate category, and gradual decrease in the rest) with lower density (20 plants∙ha-1; 0.4 %) in category 6, and higher density (2 320 plants∙ha-1; 51 %) in category 4 which also had the highest IVI (92.8 to 126.1). Spatial distribution was aggregated in TC1 to TC4 and randomized in TC5. Conclusions: Topographic conditions influenced the vertical structure and spatial distribution of oregano.
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Sumithra Ramakrishna, Shivaraja Munikrishnappa e Arul Selvamary Thomaiyar. "The Effect of Linear, Parabolic and Inverted Parabolic Salinity Gradients on The Onset of Darcy Brinkman Rayleigh Benard Two-Component Convection in a Two-Layered System with Dufour Effect". Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 101, n.º 2 (20 de janeiro de 2023): 121–36. http://dx.doi.org/10.37934/arfmts.101.2.121136.
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The physical configuration of the problem of Darcy Brinkman (DB) Rayleigh Benard Two-Component (RBTC) Convection in a two-layered system has been investigated for linear, parabolic and inverted parabolic salinity gradients with the Dufour effect. For the fluid layer, the upper boundary is free with surface tension and for the porous layer, the lower boundary is rigid. At the interface, the normal velocity, normal stress, shear stress, mass, mass flux, heat, and heat flux are continuous. The regular perturbation method is used to solve the resulting ordinary differential equations obtained from normal mode expansion. The effect of different physical parameters on the Rayleigh number versus depth ratio is discussed and results are presented graphically.
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Khan, Sara, Palma Solano-Paez, Jordan R. Hansford, Mei Lu, Salma Al-karmi, Lydia Leung, Ashley Plant-Fox et al. "INNV-43. MORE THAN WHAT MEETS THE EYE: ETMR AN UNDER RECOGNISED ATYPICAL BRAINSTEM PRIMARY. A RARE BRAIN TUMOR CONSORTIUM (RBTC) STUDY". Neuro-Oncology 23, Supplement_6 (2 de novembro de 2021): vi114—vi115. http://dx.doi.org/10.1093/neuonc/noab196.453.
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Abstract 10% of all pediatric brain tumors arise in the brainstem. Amongst these gliomas are the most common while other entities are rare and infrequently described in the literature. In this study we investigated the prevalence of non-gliomatous tumors in the brainstem. Amongst the 1323 embryonal tumours received at the RBTC, we identified 17 cases of ETMRs (17/165) that presented as brainstem primaries. Previously grouped within CNS-PNETs, ETMR, is a new WHO diagnostic entity, characterized by C19MC alterations. ETMR is a disease of infancy, the clinical spectrum of which is poorly understood. ETMRs arise at multiple CNS locations including cerebrum being most common (60%,) followed by cerebellum (18%) and midline structures (6%); notably 10% were brainstem primaries, mimicking DIPG radiologically. All patients presented with a short history of progressive neurological symptoms, with most common signs and symptoms of cranial neuropathies, long tract signs and gait disturbance. Median age at diagnosis was 27 months (range 16-75months) with a male to female ratio of 0.9:1. Predominantly localized (M0-94%, M2-3 -6%) majority of patients underwent upfront biopsy or partial resection (15/17:88%), while complete tumor resection was achieved in 2 cases. All patients received heterogenous combination of chemotherapy with and without radiotherapy. Majority of patients progressed rapidly with median time to progression of 4 months and overall survival of < 13 months. The only long-term surviving patient had complete resection dose intensified chemotherapy and radiation (OS 202months). Primary ETMRs in the brainstem are under recognised entities and carry a dismal prognosis. Although rapidly progressive, prompt recognition, maximal resection and management with multimodal adjuvant therapy should be considered in cases with brainstem disease.
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Adeloye, Adewale O., e Peter A. Ajibade. "Synthesis and Photophysical and Electrochemical Properties of Functionalized Mono-, Bis-, and Trisanthracenyl Bridged Ru(II) Bis(2,2′:6′,2″-terpyridine) Charge Transfer Complexes". Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/570864.
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With the aim of developing new molecular devices having long-range electron transfer in artificial systems and as photosensitizers, a series of homoleptic ruthenium(II) bisterpyridine complexes bearing one to three anthracenyl units sandwiched between terpyridine and 2-methyl-2-butenoic acid group are synthesized and characterized. The complexes formulated as bis-4′-(9-monoanthracenyl-10-(2-methyl-2-butenoic acid) terpyridyl) ruthenium(II) bis(hexafluorophosphate) (RBT1), bis-4′-(9-dianthracenyl-10-(2-methyl-2-butenoic acid) terpyridyl) ruthenium(II) bis(hexafluorophosphate) (RBT2), and bis-4′-(9-trianthracenyl-10-(2-methyl-2-butenoic acid) terpyridyl) ruthenium(II) bis(hexafluorophosphate) (RBT3) were characterized by elemental analysis, FT-IR, UV-Vis, photoluminescence,1H and13C NMR spectroscopy, and electrochemical techniques by elemental analysis, FT-IR, UV-Vis, photoluminescence,1H and13C NMR spectroscopy, and electrochemical techniques. The cyclic voltammograms (CVs) of (RBT1), (RBT2), and (RBT3) display reversible one-electron oxidation processes atE1/2= 1.13 V, 0.71 V, and 0.99 V, respectively (versus Ag/AgCl). Based on a general linear correlation between increase in the length ofπ-conjugation bond and the molar extinction coefficients, the Ru(II) bisterpyridyl complexes show characteristic broad and intense metal-to-ligand charge transfer (MLCT) band absorption transitions between 480–600 nm,ε=9.45×103 M−1 cm−1, and appreciable photoluminescence spanning the visible region.
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Ramírez-Pfeiffer, C., K. Nielsen, P. Smith, F. Marín-Ricalde, C. Rodríguez-Padilla e R. Gomez-Flores. "Application of the Fluorescence Polarization Assay for Detection of Caprine Antibodies to Brucella melitensis in Areas of High Prevalence and Widespread Vaccination". Clinical and Vaccine Immunology 14, n.º 3 (31 de janeiro de 2007): 299–303. http://dx.doi.org/10.1128/cvi.00350-06.
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ABSTRACT The screening Rose Bengal test (RBT), the buffered plate agglutination test (BPAT), and the confirmatory complement fixation test (CFT) are currently approved by the World Organization for Animal Health (OIE) for diagnosis of goat brucellosis. However, RBT (at 3% or 8% cell concentration) is known to be affected by vaccinal antibodies. In the present study, Mexican and Canadian OIE tests were compared with the fluorescence polarization assay (FPA), alone or in combination, using indirect and competitive enzyme-linked immunosorbent assays as classification variables for goat sera obtained from an area of high prevalence and widespread vaccination. The relative sensitivities and specificities were, respectively, 99.7% and 32.5% for RBT3, 92.8% and 68.8% for RBT8, 98.4% and 84.8% for Canadian CFT, 83.7% and 65.5% for Mexican CFT, and 78.1% and 89.3% for FPA. The use of FPA as the confirmatory test in combination with other tests significantly increased the final specificities of the screening tests alone; BPAT, RBT3, and RBT8 plus FPA resulted in final specificities of 90%, 91.2%, and 91.3%, respectively, whereas for the combinations RBT3 plus Mexican CFT, RBT8 plus Mexican CFT, and BPAT plus Canadian CFT, specificities were 65.5%, 63.2%, and 91.7%, respectively. We suggest that FPA may be routinely applied as an adaptable screening test for diagnosis of goat brucellosis and as a confirmatory test for screening test series. Some advantages of FPA are that its cutoff can be adjusted to improve its sensitivity or specificity, it is a low-cost and easy-to-perform test of choice when specificity is relevant or when an alternative confirmatory test is not available, and it is not affected by vaccination, thus reducing the number of misdiagnosed and killed goats.
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Mandujano, Salvador, Ariana Barrera-Salazar e Antonio Vergara-Castrejón. "Similarity in plant species consumed by goat flocks in the tropical dry forest of the Cañada, Oaxaca". Revista Mexicana de Ciencias Pecuarias 10, n.º 2 (17 de junho de 2019): 490–505. http://dx.doi.org/10.22319/rmcp.v10i2.4370.
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El manejo de caprinos (Capra hircus) en sistemas extensivos es una práctica común en la Reserva de la Biosfera Tehuacán-Cuicatlán (RBTC), México. En el presente estudio se analizó la similitud de las especies de plantas consumidas por los caprinos de diferentes rebaños en un paisaje de la Cañada en Oaxaca. Se siguió a ocho rebaños en diferentes localidades durante las épocas de lluvias 2012 y la de seca 2013. Para determinar la similitud espacial y temporal entre los rebaños dependiendo de las plantas consumidas, se emplearon métodos de análisis multivariado, específicamente de agrupamiento jerárquico en el programa R. Los caprinos consumieron 84 especies, de las cuales 30 constituyen el 75 % de la dieta. De acuerdo a los análisis de similitud, Mimosa sp. y Acacia cochiliacantha fueron las especies consumidas con mayor frecuencia por todos los rebaños; mientras que Eleusine indica, Prosopis leavigata y Opuntia sp. fueron las siguientes en importancia. El rebaño de la localidad Tecomovaca fue el menos similar al resto de los rebaños estudiados. Estos resultados contribuyen al entendimiento de los hábitos de forrajeo de los caprinos en región tropical seca, donde la disponibilidad de recursos es marcadamente estacional.
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Khan, Sara, Palma Solano-Paez, Tannu Suwal, Salma Al-Karmi, Mei Lu, Ben Ho, Maryam Fouladi et al. "ETMR-22. TITLE: DEFINING THE CLINICAL AND PROGNOSTIC LANDSCAPE OF EMBRYONAL TUMORS WITH MULTI-LAYERED ROSETTES (ETMRs), A RARE BRAIN TUMOR REGISTRY (RBTC) STUDY". Neuro-Oncology 22, Supplement_3 (1 de dezembro de 2020): iii327—iii328. http://dx.doi.org/10.1093/neuonc/noaa222.225.
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Abstract ETMR, an aggressive disease characterised by C19MC alterations, were previously categorised as various histologic diagnoses. The clinical spectrum and impact of conventional multi-modal therapy on this new WHO diagnostic category remains poorly understood as a majority of ~200 cases reported to date lack molecular confirmation. We undertook comprehensive clinico-pathologic studies of a large molecularly confirmed cohort to improve disease recognition and treatment approaches. Amongst 623 CNS-PNETs patients enrolled in the RBTC registry, 159 primary ETMRs were confirmed based on a combination of FISH (125), methylation analysis (88), SNP and RNAseq (32) analyses; 91% had C19MC amplification/gains/fusions, 9% lacked C19MC alterations but had global methylation features of ETMR NOS. ETMRs arose in young patients (median age 26 months) predominantly as localized disease (M0-72%, M2-3 -18%) at multiple locations including cerebrum (60%) cerebellum (18%), midline structures (6%); notably 10% were brainstem primaries mimicking DIPG. Uni-and multivariate analyses of clinical and treatment details of curative regimens available for 110 patients identified metastatic disease (p=0.002), brainstem locations(p=0.005), extent of surgery, receipt of multi-modal therapy including high dose chemotherapy and radiation (P<0.001) as significant treatment prognosticators, while C19MC status, age and gender were non-significant risk factors. Analyses of events in all patients showed respective EFS at 3 and 12 months of 84%(95%CI:77–91) and 37%(95%CI:20–41) and 4yr OS of 27%(95%CI:18–37) indicating despite intensified therapies ETMR is a rapidly progressive and fatal disease. Our comprehensive data on the largest cohort of molecularly-confirmed ETMRs provides a critical framework to guide current clinical management and development of clinical trials.
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Shirinkina, Elena Viktorovna. "Transformation of the world job market in the conditions of the Fourth Industrial Revolution". Политика и Общество, n.º 2 (fevereiro de 2021): 8–28. http://dx.doi.org/10.7256/2454-0684.2021.2.36764.
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The relevance of this research is substantiated by the fact that the world job market is currently under the influence of the Fourth Industrial Revolution (Industry 4.0). The goal lies in assessing the impact of cyclic and unexpected trends upon the job market, and thus, the forms of job management and employment functions. In this regard, analysis is conducted on the academic theories in the context of conceptualization of the impact of Industry 4.0 upon the job market and employment functions. The long-term trends in transformation of the job market are determined. The empirical basis of this research is comprised of the statistical data provided by Rosstat and the Ministry of Science and Higher Education of the Russian Federation, as well as the resources of analytical articles and scientific publications, including the materials of international organizations, leading consulting companies, global associations, leading educational institutions, other active participants of global educational environment, and job market experts. An overview is given to the trends that affect the companies, their strategies and business models; the impact of such trends upon the transformation of current professions and the emergence of new professions; skills required for these professions. The scientific novelty lies in substantiation of the concept of skill-biased technical change (SBTC) and the theory of routine-biased technological change (RBTC). The presented materials would allow the companies to combine business news with fundamental training of specialists for going along the new career trajectiory in light of the new technological challenges, which defines the practical value of this research.
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Czempik, Piotr F., Dawid Gierczak, Dawid Wilczek e Łukasz J. Krzych. "The Impact of Red Blood Cell Transfusion on Blood Lactate in Non-Bleeding Critically Ill Patients—A Retrospective Cohort Study". Journal of Clinical Medicine 11, n.º 4 (17 de fevereiro de 2022): 1037. http://dx.doi.org/10.3390/jcm11041037.
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Anemia should preferably be managed without red blood cell transfusion (RBCT); instead, therapy should be focused on causes of anemia along with efforts to minimize blood loss. Lactate could potentially be used as a physiologic RBCT trigger, although there are some limitations to its interpretation. The aim of our study was to analyze the impact of RBCT on blood lactate with consideration of factors known to increase its concentration and to assess the usefulness of blood lactate as a potential physiologic RBCT trigger. We performed a retrospective analysis of all RBCT episodes in non-bleeding critically ill patients. We retrieved demographic data, data on RBCT itself (duration, type of RBC, volume of RBC, age of RBC), laboratory parameters (lactate, hemoglobin, glucose, total bilirubin), and factors potentially increasing lactate. We analyzed 77 RBCTs with elevated pre-RBCT lactate. The median age of patients was 66 (IQR 57–73) years and the distribution of sexes was even. The named factors potentially influencing lactate had no impact on its concentration. The median pre-post RBCT lactate was 2.44 (IQR 2.08–3.27) and 2.13 (IQR 1.75–2.88) mmol/L, respectively (p < 0.01); the median decrease was 0.41 (IQR 0.07–0.92) mmol/L. We conclude that RBCT did not normalize mildly elevated lactate. Common causes of elevated lactate probably had no impact on its concentration. Therefore lactate may have a limited role as a physiologic RBCT trigger in non-bleeding severely anemic critically ill patients.
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Vasconcelos, Edivaldo Gomes, e Maria das Graças Teles Martins. "ANSIEDADE NA PANDEMIA COVID-19: INFLUÊNCIAS NO APRENDIZADO DA EJA - EDUCAÇÃO DE JOVENS E ADULTOS E TERAPIA COGNITIVO COMPORTAMENTAL NA INTERVENÇÃO". Revista Ibero-Americana de Humanidades, Ciências e Educação 8, n.º 7 (30 de julho de 2022): 798–820. http://dx.doi.org/10.51891/rease.v8i7.6180.
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INTRODUÇÃO: As implicações emocionais provocadas pela pandemia da COVID-19, especificamente, a ansiedade, atinge inúmeras pessoas em nível mundial e, em especial, alunos jovens e adultos. Percebe-se que as emoções, afeto, sentimentos e comportamento estão na base de todas as ações humanas, dentre elas, a aprendizagem. A aprendizagem é o processo por meio do qual o indivíduo se apropria ativamente de uma rede de conhecimentos inseridos em sua experiência humana no contexto familiar, escolar, grupal, social, além do conhecimento dos valores sociais daquilo que o seu grupo social ensina. O panorama atual da educação envolve muitas medidas para prevenir o contágio do vírus, como o distanciamento e isolamento social e aulas remotas, o que implica na geração de diversos impactos emocionais transtornantes nos alunos. OBJETIVO: Discutir como a ansiedade, nesse período pandêmico, tem interferido na aprendizagem de alunos da EJA e destacar as contribuições da Terapia Cognitivo Comportamental na intervenção. METODOLOGIA: É fundamentada na revisão teórica da literatura com o método de pesquisa bibliográfica, qualitativa e exploratória. Os materiais constituíram-se em livros, dissertações, artigos científicos disponíveis em Periódicos Capes, SciELO, Bvsalud, Pepsic, Revista Brasileira de Terapias Cognitivas (RBTC), Google Academy, no período de 2010 à 2022. RESULTADOS: Evidenciou-se que a ansiedade produzida durante o período da Covid-19 trouxe prejuízos na educação de jovens e adultos; presença de sintomas de angústia, inquietação, medo intenso, preocupação; o isolamento e outras medidas adotadas contra a pandemia influenciam no comportamento emocional dos alunos, provocando dificuldades na cognição e interação social, que são fatores importantes para aprendizagem. CONSIDERAÇÕES FINAIS: Os efeitos psicossocioemocinais provocados pela ansiedade imposta pela Covid-19 inferiu negativamente no comportamento e aprendizagem dos alunos jovens e adultos. A intervenção psicoterapêutica Cognitivo Comportamental, voltada para a redução dos sintomas, pode melhorar a capacidade cognitiva, como a atenção, concentração, fortalecimento emocional, visando o bem-estar físico, mental e educacional dos alunos.
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Ширинкина, Елена Викторовна. "IMPACT OF INDUSTRY 4.0 ON CHANGES IN THE CONTENT OF LABOR FUNCTIONS". Вестник Тверского государственного университета. Серия: Экономика и управление, n.º 4(56) (27 de dezembro de 2021): 124–32. http://dx.doi.org/10.26456/2219-1453/2021.4.124-132.
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Актуальность исследования обусловлена тем, что текущий мировой рынок труда находится под воздействием IV промышленной революции (Индустрия 4.0). Цель исследования - оценить влияние циклических и внезапных трендов, воздействующих на рынок труда, и, как следствие, на формы организации труда и трудовые функции работников. В этой связи автором рассмотрены академические теории в контексте концептуализации влияния Индустрии 4.0 на рынок труда и трудовые функции, определены долгосрочные тренды трансформации рынка профессий. Научная новизна исследования заключается в обосновании концепции «Skills-biased technical change», смещенного в пользу высококвалифицированной рабочей силы, и теории вытеснения рутинного труда «Routine-biased technological change». Практическая значимость исследования заключается в обосновании выводов, учет которых позволит компаниям в условиях новых технологических вызовов соединить потребности бизнеса с фундаментальной подготовкой специалиста для его движения по новой карьерной траектории. The relevance of the study is due to the fact that the current world labor market is under the influence of the IV industrial revolution (Industry 4.0). The purpose of the study is to assess the impact of cyclical and sudden trends affecting the labor market and, as a consequence, the forms of labor organization and labor functions of workers. In this regard, the author examines academic theories in the context of conceptualizing the impact of Industry 4.0 on the labor market and labor functions, identifies long-term trends in the transformation of the professions market. The scientific novelty of the research lies in the substantiation of the concept, biased in favor of a highly skilled labor force (skills-biased technical change, SBTC) and the theory of displacement of routine labor (routine-biased technological change, RBTC). The practical significance of the study lies in the fact that it will allow companies in the face of new technological challenges to combine business needs with the fundamental training of a specialist for his movement along a new career path.
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Sidhar, Meenakshi. "The Prevalence of Transfusion-Transmitted Infections (TTIs) and Distribution Pattern of ABO Rh Blood Group in Blood Donors and Possible Correlation of TTIs with ABO and Rh Blood Groups – A Study at RBTC (North-West) Delhi". Journal of Advanced Research in Medicine 05, n.º 01 (2 de abril de 2018): 16–20. http://dx.doi.org/10.24321/2349.7181.201805.
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Cui, Shijie, Dan Dan Huang, Yangzhou Wu, Junfeng Wang, Fuzhen Shen, Jiukun Xian, Yunjiang Zhang et al. "Chemical properties, sources and size-resolved hygroscopicity of submicron black-carbon-containing aerosols in urban Shanghai". Atmospheric Chemistry and Physics 22, n.º 12 (22 de junho de 2022): 8073–96. http://dx.doi.org/10.5194/acp-22-8073-2022.
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Abstract. Refractory black carbon (rBC) aerosols play an important role in air quality and climate change, yet highly time-resolved and detailed investigations on the physicochemical properties of rBC and its associated coating are still scarce. In this work, we used a laser-only Aerodyne soot particle aerosol mass spectrometer (SP-AMS) to exclusively measure rBC-containing (rBCc) particles, and we compared their properties with those of the total nonrefractory submicron particles (NR-PM1) measured in parallel by a high-resolution AMS (HR-AMS) in Shanghai. Observations showed that, overall, rBC was thickly coated, with an average mass ratio of coating to rBC core (RBC) of ∼5.0 (±1.7). However, the ratio of the mass of the rBC-coating species to the mass of those species in NR-PM1 was only 19.1 (±4.9) %; sulfate tended to condense preferentially on non-rBC particles, so the ratio of the sulfate on rBC to the NR-PM1 sulfate was only 7.4 (±2.2) %, while the majority (72.7±21.0 %) of the primary organic aerosols (POA) were associated with rBC. Positive matrix factorization revealed that organics emitted from cooking did not coat rBC, and a portion of the organics that coated rBC was from biomass burning; such organics were unidentifiable in NR-PM1. Small rBCc particles were predominantly from traffic, while large-sized ones were often mixed with secondary components and typically had a thick coating. Sulfate and secondary organic aerosol (SOA) species were generated mainly through daytime photochemical oxidation (SOA formation, likely associated with in situ chemical conversion of traffic-related POA to SOA), while nocturnal heterogeneous formation was dominant for nitrate; we also estimated an average time of 5–19 h for those secondary species to coat rBC. During a short period that was affected by ship emissions, particles were characterized as having a high vanadium concentration (on average 6.3±3.1 ng m−3) and a mean vanadium/nickel mass ratio of 2.0 (±0.6). Furthermore, the size-resolved hygroscopicity parameter (κrBCc) of rBCc particles was obtained based on their full chemical characterization, and was parameterized as κrBCc(x)=0.29–0.14 × exp(-0.006×x) (where x ranges from 150 to 1000 nm). Under critical supersaturations (SSC) of 0.1 % and 0.2 %, the D50 values were 166 (±16) and 110 (±5) nm, respectively, and 16 (±3) % and 59 (±4) %, respectively, of the rBCc particles by number could be activated into cloud condensation nuclei (CCN). Our findings are valuable for advancing the understanding of BC chemistry as well as the effective control of atmospheric BC pollution.
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Yu, Chenjie, Dantong Liu, Kang Hu, Ping Tian, Yangzhou Wu, Delong Zhao, Huihui Wu et al. "Aerodynamic size-resolved composition and cloud condensation nuclei properties of aerosols in a Beijing suburban region". Atmospheric Chemistry and Physics 22, n.º 7 (5 de abril de 2022): 4375–91. http://dx.doi.org/10.5194/acp-22-4375-2022.
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Abstract. The size-resolved physiochemical properties of aerosols determine their atmospheric lifetime, cloud interactions and the deposition rate on the human respiratory system; however most atmospheric composition studies tend to evaluate these properties in bulk. This study investigated size-resolved constituents of aerosols on mass and number basis, and their droplet activation properties, by coupling a suite of online measurements with an aerosol aerodynamic classifier (AAC) based on aerodynamic diameter (Da) in Pinggu, a suburb of Beijing. While organic matter accounted for a large fraction of mass, a higher contribution of particulate nitrate at larger sizes (Da>300 nm) was found under polluted cases. By considering the mixing state of refractory-black-carbon-containing particles (rBCc) and composition-dependent densities, aerosols including rBCc were confirmed to be nearly spherical at Da>300 nm. Importantly, the number fraction of rBCc was found to increase with Da at all pollution levels. The number fraction of refractory black carbon (rBC) is found to increase from ∼3 % at ∼90 nm to ∼15 % at ∼1000 nm, and this increasing rBC number fraction may be caused by the coagulation during atmospheric ageing. The droplet activation diameter at a water supersaturation of 0.2 % was 112±6 and 193±41 nm for all particles with Da smaller than 1 µm (PM1) and rBCc respectively. As high as 52±6 % of rBCc and 50±4 % of all PM1 particles in number could be activated under heavy pollution due to enlarged particle size, which could be predicted by applying the volume mixing of substance hygroscopicity within rBCc. As rBCc contribute to the quantity of aerosols at larger particle size, these thickly coated rBCc may contribute to the radiation absorption significantly or act as an important source of cloud condensation nuclei (CCN). This size regime may also exert important health effects due to their higher deposition rate.
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Ramírez-Pfeiffer, Carlos, Efrén Díaz-Aparicio, Ricardo Gomez-Flores, Cristina Rodríguez-Padilla, Alberto Morales-Loredo e Genoveva Álvarez-Ojeda. "Use of the Brucella melitensis Native Hapten To Diagnose Brucellosis in Goats by a Rapid, Simple, and Specific Fluorescence Polarization Assay". Clinical and Vaccine Immunology 15, n.º 6 (2 de abril de 2008): 911–15. http://dx.doi.org/10.1128/cvi.00046-08.
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ABSTRACT The performance of the fluorescence polarization assay (FPA) using the recently described Brucella melitensis native hapten and the Brucella abortus O-polysaccharide tracer was evaluated and compared with those of The World Organization for Animal Health tests related to indirect and competitive enzyme-linked immunosorbent assays as classification variables for goat sera obtained from a high-prevalence area where vaccination was performed; test series were also evaluated to increase the final specificity of the tests. Our results showed that the respective relative sensitivity and specificity were 99.7% and 32.5% for the rose Bengal test with a 3% cell concentration (RBT3), 92.8% and 68.8% for the rose Bengal test with 8% cell concentration (RBT8), 98.4% and 84.9% for the Canadian complement fixation test (CFT), 83.7% and 65.5% for the Mexican CFT, 98.4% and 81.0% for the buffered plate agglutination test (BPAT), and 78.1% and 89.3% for the fluorescence polarization assay (FPA). The use of the FPA as the secondary test significantly increased the final specificities of test combinations; the screening tests BPAT, RBT3, and RBT8 plus FPA resulted in 90%, 91.2%, and 91.3% final specificities, respectively, whereas for the combinations RBT3 plus Mexican CFT, RBT8 plus Mexican CFT, and BPAT plus Canadian CFT, the specificities were 65.5%, 63.2%, and 91.7%, respectively. The results suggested that the FPA may be routinely applied as an adaptable screening test for diagnosis of goat brucellosis, since its cutoff can be adjusted to improve its sensitivity or specificity, it is a rapid and simple test, it can be the test of choice when specificity is relevant or when an alternative confirmatory test is not available, and it is not affected by vaccination, thus reducing the number of goats wrongly slaughtered due to misdiagnosis.
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Arnan Sangerman, Montserrat, Helena Pomares, Esther Alonso, Javier Grau, Mercedes Galiano, Maite Encuentra e Anna Sureda. "Impact of Red Blood Cell Transfusion Burden Status in Patients with Lower-Risk Myelodysplastic Syndromes". Blood 134, Supplement_1 (13 de novembro de 2019): 3013. http://dx.doi.org/10.1182/blood-2019-127486.
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Background: RBC-transfusion dependency (RBC-TD) is associated with a decreased probability of overall survival (OS) and progression free survival (PFS) in patients with myelodysplastic syndromes (MDS) (Malcovati L et al. J Clin Oncol 2007 25:3505) but it is unclear if transfusion dose burden is an independent prognostic factor. The purpose of this study was to assess the impact on lower-risk MDS patients, of RBC-transfusion (RBCT) burden status defined according to revised 2018 IWG criteria (Platzbecker et al; Blood 2018). Material and Methods: According to the R-IPSS selection criteria, we identified in our database 474 lower-risk (R-IPSS risk very low, low and intermediate) MDS patients diagnosed at the Catalan Institute of Oncology of Barcelona (01/1992-07/2018). Transfusion burden history was prospectively registered in our database. Data on the transfusion burden was calculated dividing the cumulative total of units of blood received at the end by the time since the beginning of the interval in which the first transfusion was received. RBCT burden, defined according to 2018 IWG criteria, divided patients into 3 categories (non-transfused [NTD], low transfusion burden [LTB] (3 to 7 units in 16 weeks) and high transfusion burden [HTB] patients (³ 8 units in 16 weeks). In this analysis, patients who had received 1 or 2 RBC units in 16 weeks, where included in the NTD category. Overall survival (OS) and progression free survival (PFS) were measured in years since diagnosis. Results: Median age at diagnosis was 72 years (range 32-101). 332 (70%) patients were male. WHO diagnosis was: 3% CRDU, 7% RA, 42% RCMD, 14% RAEB-1, 4% RAEB-2, 26% CMML, the remaining 4% were MDS-U and isolated 5q deletion. R-IPSS categories were: 178 (38%) very low risk, 219 (46.2%) low risk and 77 (16%) intermediate risk. Median follow up time for survivors was 5.4 years (range 0.25-23.8). 132 (28%) of patients were transfusion dependents (LTB and HTB patients). Mean dose density of packed red blood cells amongst those who were transfusion dependents was 3.2 units per month, with a median of 2.9 units per month (IQR 1.9-4.3). At the time of last follow up, 274 (58%) patients had died and 72 (15%) had progressed to AML. According to 2018 IWG criteria, RBCT burden categories were 342 (72%) NTD, 35 (7%) LTB and 97 (21%) HTB patients. Median OS for RBCT burden categories: NTD (8 years; 95% CI 6.6-9.5), LTB (6.2 years; 95% CI 4.2-8.1) and HTB (3.1 years; 95% CI 2.4-3.8) were significantly different (p<0.001; Figure 1). Moreover, the rate of progression to acute myeloid leukemia was 39 (11%), 7 (20%) and 26 (27%) for categories NTD, LTB and HTB respectively (p<0.001). Multivariate analysis performed included gender, age at diagnosis, IPSS-R and RBCT burden status and showed that RBCT burden status was associated with poor OS and PFS, independent of R-IPSS category, age and gender (Table 1). Transfusion burden was inversely associated with OS and PFS with an increasing effect on hazard ratio. Conclusions: Our results confirm in our single-centre experience the negative impact on survival and progression-free survival of RBCT treatment, even at relatively low dose burden. As therapeutical decisions are based on the initial prognostic risk assessment, the inclusion of RBCT burden categories may provide more precise prognostic information with impact on the therapeutic approach. Disclosures Sureda: Novartis: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Speakers Bureau; Sanofi: Consultancy, Honoraria; Roche: Honoraria; BMS: Consultancy, Honoraria; Gilead: Consultancy; Janssen: Consultancy, Honoraria.
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Aydinok, Yesim, Antonio Piga, Raffaella Origa, Nina Mufti, Anna Erikson, Anne North, Katie Waldhaus et al. "Hemoglobin Utilization in Asplenic and Non-Splenectomized Transfusion Dependent Thalassemia Patients Supported with Pathogen Reduced Red Blood Cell Concentrates in a Phase 3 Study (SPARC)". Blood 132, Supplement 1 (29 de novembro de 2018): 3812. http://dx.doi.org/10.1182/blood-2018-99-112685.
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Abstract Introduction: Transfusion dependent thalassemia (TDT) requires regular transfusion of red cell concentrates (RBCC) to prevent the complications of anemia and excessive erythroid expansion. Despite donor testing, long-term transfusion has a substantial cumulative risk of transfusion-transmitted infection (TTI) due to undetected viruses, bacteria, and protozoa. Splenectomized (-S) TDT patients may have greater TTI morbidity than patients with spleens (+S); but may benefit from reduced use of red blood cell concentrates (RBCC) and reduced transfusion iron (Fe) loading. Pathogen reduction (PR) of RBCC with amustaline-glutathione (A-GSH) offers potential to reduce the risk of TTI. Objectives: To determine, the impact of PR-RBCC on hemoglobin (Hb) use, transfused Fe burden, incidence of RBC antibodies, and safety in -S and +S TDT patients. Methods: TDT patients at 3 sites, not stratified by spleen status, were prospectively enrolled in a two- period cross-over study randomized by sequence for RBCC preparation. Leukocyte reduced PR-RBCC (Test) were treated with 0.2mM amustaline and 20 mM GSH, re-suspended in saline-adenine-glucose mannitol (SAGM), and stored up to 35 days at 4°C. Leukocyte reduced conventional RBCC (Control) were suspended in SAGM and stored for up to 35 days at 4°C. Patients received 6 transfusions in each treatment sequence of Test or Control RBCC over ~ 5 months. Clinicians, blinded to RBCC Hb content and treatment sequence, ordered RBCC to maintain targeted pre-transfusion Hb thresholds of ~ 9-10 g/dL. Transfusion intervals or number of RBCC transfused were adjusted for clinical management. The primary efficacy outcome was assessed by non-inferiority (NI) analysis for Hb use (expressed as g/kg body weight/ day) using a pre-specified NI margin (≤ 15% of the observed Control mean). Results : Overall, mean (SD) Hb content (g) of 1024 Test RBCC = 54.6±5.9 (range: 39-73) and of 1008 Control RBCC = 55.6 ± 5.9 (range: 35-74) and varied widely. By intent-to-treat (ITT), 80 patients (40 +S and 40 -S) were transfused. For ITT patients (Table), the baseline Hb level (BL-Hb, g/dL) at first transfusion of Control periods was significantly lower than at Test periods; but the mean number of RBCC transfused, RBCC storage days, total Hb dose (g), and transfusion intervals were not significantly different for Test and Control. ITT analysis for all transfusion episodes showed Hb use for Test RBCC (0.110 g/kg/d) was not different from Control RBCC (0.112 g/kg/day). Non-inferiority was demonstrated (T-C = - 0.002 g/kg/d: 95% CI: -0.005, 0.001). ITT Test patients received a slightly lower mean total Hb dose (- 14g), and mean pre-transfusion Hb levels declined after 6 transfusions (9.4 to 8.8 g/dL). -S patients had lower BL-Hb levels (g/dL) than S+ patients in Test (9.2 vs 9.7) and Control (8.8 vs 9.2) periods (Table). -S patients received a lower mean total Hb dose of Test than Control RBCC (p=0.019); and had a decline in mean pre-transfusion Hb levels during Test periods (from 9.2 to 8.7 g/dL). Transfusion intervals were significantly longer for -S patients than +S patients with both Test and Control RBCC (p< 0.001 by 2-sample t test, respectively); and -S patients had lower Hb use than +S patients. However, Hb use of Test and Control RBCC was comparable within -S and + S cohorts (Table). Transfused Fe was less for -S patients for Test and Control RBCC. During 6 Test and 3 Control treatment periods, 8 patients (6 -S, 2 +S) had worsening anemia with pre-transfusion Hb levels (6.0-7.8 g/dL) substantially below the targeted transfusion threshold, but without evidence of hemolysis. Each of these patients received one or more Hb doses below the average RBCC transfusion episode dose (Test: 114.5 g) or (Control: 116.7 g); and 3 patients had concurrent infections. None of 80 patients had evidence of increased RBC clearance, developed antibodies to PR-RBCC, or had treatment emergent RBC alloantibodies in either treatment period. There were no differences in the overall safety profiles for Test and Control RBCC. Conclusions: Amustaline-GSH PR treatment of RBCCs offers the potential to reduce TTI risk without impacting Hb use or Fe burden in TDT. However, Hb content of Test and Control RBCC varies widely and may contribute to unexpected changes in pre-transfusion Hb levels. Spleen status affected Hb use comparably for PR-RBCC and Control RBCC, and remains an important factor in assessing transfusion requirements and Fe loading. Table. Table. Disclosures Aydinok: TERUMO: Research Funding; Cerus: Honoraria, Research Funding; CRISPR Tech: Other: DMC; Protagonist: Other: SSC; La Jolla Pharmaceuticals: Research Funding; Celgene: Research Funding; Novartis: Research Funding, Speakers Bureau. Piga:Apopharma: Honoraria, Research Funding; Celgene Corp: Membership on an entity's Board of Directors or advisory committees, Research Funding; La Jolla: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bluebird Bio: Honoraria; Acceleron: Research Funding; Novartis: Research Funding. Origa:Novartis: Honoraria; Bluebird Bio: Consultancy; Cerus Corporation: Research Funding; Apopharma: Honoraria. Mufti:Cerus Corporation: Employment, Equity Ownership. Erikson:Cerus Corporation: Employment, Equity Ownership. North:Cerus Corporation: Employment, Equity Ownership. Waldhaus:Cerus Corporation: Employment, Equity Ownership. Ernst:Cerus Corporation: Employment, Equity Ownership. Lin:Cerus Corporation: Employment, Equity Ownership. Huang:Cerus Corporation: Employment, Equity Ownership. Benjamin:Cerus Corporation: Employment, Equity Ownership. Corash:Cerus Corporation: Employment, Equity Ownership.
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Piercey, Oliver A., Zoe Loh, Joanna Chan, Geoff Chong, Andrew Grigg, Steven Cheema, Gurjot Gill, Matthew Whybird, Tania Cushion e Eliza A. Hawkes. "Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression". JCO Oncology Practice 16, n.º 11 (novembro de 2020): e1315-e1323. http://dx.doi.org/10.1200/jop.19.00771.
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PURPOSE: Patients with indolent non-Hodgkin lymphoma (iNHL) undergo regular active surveillance in between treatment periods to detect disease relapse or progression. As part of surveillance, international guidelines recommend regular routine blood testing, which is based on consensus rather than evidence of utility. METHODS: We conducted a retrospective analysis of all patients older than age 16 years diagnosed with grade 1-3A follicular or marginal zone lymphoma between 2008 and 2017 from 2 Australian cancer centers to assess the utility of full blood examination, lactate dehydrogenase, and β2-microglobulin in detecting progression events, defined as either disease relapse or progression of disease. RESULTS: One hundred eighty patients attended 1,757 outpatient appointments (median follow-up, 36 months). Routine blood tests (RBTs) were performed before 83% of appointments. Seventy-four progression events occurred in 62 patients. Only 2 events (3%) were detected by RBTs alone, both of which occurred in treatment-naïve patients who subsequently developed symptoms within 3 weeks. The remainder of progression events were suspected clinically (88%) or detected by imaging (9%). RBT results were frequently abnormal in asymptomatic patients (19%), with abnormal results leading to either additional investigations or an increased surveillance frequency in 8% of cases. The overall sensitivity and positive predictive value of abnormal RBT results in detecting progression events were 39% and 9%, respectively. CONCLUSION: RBTs have poor performance characteristics and rarely detect clinically significant disease progression or relapse in asymptomatic patients with iNHL.
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Kim, Chulho, Sang-Hwa Lee, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Yerim Kim, Ju-Hun Lee, Min Uk Jang, San Jung e Byung-Chul Lee. "Timing of Transfusion, not Hemoglobin Variability, Is Associated with 3-Month Outcomes in Acute Ischemic Stroke". Journal of Clinical Medicine 9, n.º 5 (21 de maio de 2020): 1566. http://dx.doi.org/10.3390/jcm9051566.
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Objectives: This study aimed to investigate whether transfusions and hemoglobin variability affects the outcome of stroke after an acute ischemic stroke (AIS). Methods: We studied consecutive patients with AIS admitted in three tertiary hospitals who received red blood cell (RBC) transfusion (RBCT) during admission. Hemoglobin variability was assessed by minimum, maximum, range, median absolute deviation, and mean absolute change in hemoglobin level. Timing of RBCT was grouped into two categories: admission to 48 h (early) or more than 48 h (late) after hospitalization. Late RBCT was entered into multivariable logistic regression model. Poor outcome at three months was defined as a modified Rankin Scale score ≥3. Results: Of 2698 patients, 132 patients (4.9%) received a median of 400 mL (interquartile range: 400–840 mL) of packed RBCs. One-hundred-and-two patients (77.3%) had poor outcomes. The most common cause of RBCT was gastrointestinal bleeding (27.3%). The type of anemia was not associated with the timing of RBCT. Late RBCT was associated with poor outcome (odd ratio (OR), 3.55; 95% confidence interval (CI), 1.43–8.79; p-value = 0.006) in the univariable model. After adjusting for age, sex, Charlson comorbidity index, and stroke severity, late RBCT was a significant predictor (OR, 3.37; 95% CI, 1.14–9.99; p-value = 0.028) of poor outcome at three months. In the area under the receiver operating characteristics curve comparison, addition of hemoglobin variability indices did not improve the performance of the multivariable logistic model. Conclusion: Late RBCT, rather than hemoglobin variability indices, is a predictor for poor outcome in patients with AIS.
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Kansagra, Ankit, Chester Andrzejewski, Robert Krushell, Andrew Lehman, Jordan Greenbaum, Paul Visintainer, Joan McGirr et al. "Blood Management Strategies to Reduce Transfusions After Elective Lower-Extremity Joint Arthroplasty Surgeries: One Tertiary Care Hospital’s Early Experience With an Alternative Payment Model—a Total Joint “Bundle”". American Journal of Medical Quality 32, n.º 6 (20 de janeiro de 2017): 668–74. http://dx.doi.org/10.1177/1062860616687035.
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Blood loss associated with lower-extremity total joint arthroplasty (TJA) often results in anemia and the need for red blood cell transfusions (RBCTs). This article reports on a quality improvement initiative aimed at improving blood management strategies in patients undergoing TJA. A multifaceted intervention (preoperative anemia assessment, use of tranexamic acid, discouragement of autologous preoperative blood collection, restrictive RBCT protocols) was implemented. The results were stratified into 3 intervention periods: 1, pre; 2, peri; and 3, post. Fractional logistic regression was used to describe differences between various intervention periods. During the study period, 2511 patients underwent TJA. Compared with the preintervention period, there was 81.8% decrease in total units of RBCT during the postintervention period. Using activity-based costing (~$1000/unit), the annualized saving in RBC expenditure was $480 000. A multidisciplinary approach can be successful and sustainable in reducing RBCT and its associated costs for patients undergoing TJA.
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De Swart, Louise, Tom Johnston, Alexandra Smith, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Eva Hellström-Lindberg et al. "Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EU-MDS Registry". Blood 126, n.º 23 (3 de dezembro de 2015): 1677. http://dx.doi.org/10.1182/blood.v126.23.1677.1677.
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Abstract Background The outcome of lower-risk MDS patients with red blood cell transfusions (RBCT) dependency is inferior to that of RBCT independent patients, but whether the intensity of RBCT is important for prognosis is unknown. The EUMDS Registry is a non-interventional, observational longitudinal study enrolling patients with lower-risk MDS from 142 sites in 17 countries as described elsewhere (1). The EUMDS registry has accrued 1,902 patients as of July 21, 2015. We hypothesized that RBCT intensity is an independent prognostic factor for survival. Methods We first assessed the impact of RBCT intensity in the first year post-diagnosis (1yrPD) on progression-free survival among the 1034 patients who survived at least 1yrPD and had potential for a further year of follow-up. Secondly, we developed a longitudinal model of platelet counts throughout follow-up for 1660 patients in the registry with potential for at least one year follow-up. Results Among the 1034 patients, 323 patients had died: 67 after progression to higher-risk MDS/AML and 256 without progression. A further 41 surviving patients had progressed to AML. The overall 5-year survival was 52%. In a proportional hazards regression model (Table), the risk of death or progression increased in a non-linear fashion with age at diagnosis (p<0.001). The risk of death was increased in the intermediate IPSS-R risk group compared to low risk. Patients with RARS and 5q- syndrome had a better outcome compared to RCMD. Increased RBCT intensity in 1yrPD (Table, Figure) was strongly associated with an increased risk of death (p<0.001). In the 1660 patients no significant decline in platelet counts was observed (0.16x109 platelets/l average monthly decline, p=0.16) among patients who were not RBC transfused at any time during follow-up. However platelet counts of patients receiving RBCT declined more quickly (p<0.0001) at an average rate of 1.14x109 platelets/l/month. Among the 920 RBCT dependent patients, lower platelet counts were associated with receiving more RBCT units in the preceding six months. 185 Patients had at least 2 observations both before and after becoming RBCT dependent, defined as 1st RBCT. 50% of these patients had a decreasing trend of platelets prior to their 1st RBCT and 67% had a decreasing slope of platelets after their 1st RBCT. In the control group of RBC untransfused patients, decreasing slopes of platelets occurred in around 50% of the patients throughout the whole observation period of 4 visits. Logistic regression of the risk of having a post-1st RBCT decreasing trend in platelets showed that transfused patients were at a greater risk (OR=1.7, 95% CI: 1.1-2.7) of having a post-1st RBCT decreasing trend in platelets than untransfused patients. Conclusion These multivariate regression models including age, sex, country, IPSS and WHO classification showed that more intensive RBCT treatment is associated with poor prognosis and a more rapid decline of platelets. This indicates that the intensity of RBCT should be incorporated in the regular prognostic scoring systems and the choice of therapeutic interventions. (1): De Swart L et al. Br J Haematol 2015; 170: 372-83. Disclosures Fenaux: NOVARTIS: Honoraria, Research Funding; CELGENE: Honoraria, Research Funding; JANSSEN: Honoraria, Research Funding; AMGEN: Honoraria, Research Funding. Hellström-Lindberg:Celgene Corporation: Research Funding. Sanz:JANSSEN CILAG: Honoraria, Research Funding, Speakers Bureau. Mittelman:Roche: Research Funding; Novartis Pharmaceuticals Corporation: Research Funding; GlaxoSmithKline: Research Funding; Johnson & Johnson: Research Funding, Speakers Bureau; Celgene: Research Funding, Speakers Bureau; Amgen: Research Funding. Almeida:Bristol Meyer Squibb: Speakers Bureau; Shire: Speakers Bureau; Celgene: Consultancy; Novartis: Consultancy. Park:Hospira: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Research Funding. Itzykson:Oncoethix: Research Funding. de Witte:Novartis: Research Funding.
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Hallet, Julie I., Melanie Tsang, Eva Cheng, Iryna B. Kulyk, Sherif Hanna, Calvin Law, Natalie G. Coburn e Paul Jack Karanicolas. "The impact of perioperative red blood cell transfusion on long-term survival after hepatectomy for colorectal liver metastases." Journal of Clinical Oncology 33, n.º 3_suppl (20 de janeiro de 2015): 725. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.725.
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725 Background: Perioperative red blood cell transfusions (RBCT) are associated with postoperative morbidity and may increase cancer recurrence through immunologic mechanisms following resection of colorectal liver metastases (CRLM). We sought to explore the relationship between RBCTs and long-term survival following resection of CRLM in the contemporary surgical era. Methods: We conducted a retrospective review of a prospective database including all patients undergoing partial hepatectomy for CRLM from 2003-2012. Data regarding date of death was abstracted from a validated, population-based cancer registry. Primary outcome was overall survival (OS), compared based on RBCT (defined as time of surgery to 30 days following surgery) and on number of RBC units received using Kaplan-Meier curves. Cox regression analysis was performed to examine the association between RBCT and OS, while adjusting for prognostic factors including Fong score and period of treatment (2003-2007 vs. 2008-2012). Results: We included 483 patients operated for CRLM, of which 27.5% received RBCT. 90-day post-operative mortality was 4.8% and median follow-up was 33 (IQR: 20.1-54.8) months. Median survival in patients who received RBCT was 44.5 months compared with 93.5 months in patients who did not(p<0.0001). The difference persisted in subgroup analysis excluding patients who died within 90 days of surgery (62.3 vs. 93.5 months, p=0.023). After adjustment for Fong score and period of treatment, RBCT was independently associated with decreased OS (HR 2.15; 95% CI: 1.52-3.04). Conclusions: Perioperative RBCT is independently associated with decreased OS following hepatectomy for CRLM. Interventions to minimize and rationalize the use of RBCT for hepatectomy are warranted in order to mitigate this detrimental effect on long-term outcomes.
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Mitra, Barsha, Shamik Sural, Jaideep Vaidya e Vijayalakshmi Atluri. "Migrating from RBAC to temporal RBAC". IET Information Security 11, n.º 5 (1 de setembro de 2017): 294–300. http://dx.doi.org/10.1049/iet-ifs.2016.0258.
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Zohrah, Laila Zohrah. "EVOLVING CONNNECTIVITY PATTERNS OF BANJARESE KAMPUNGS AND RUMAH BUBUNGAN TINGGI (HIGH RIDGE-HOUSE) IN SOUTH KALIMANTAN RIVER NETWORKS". International Journal on Livable Space 4, n.º 1 (21 de setembro de 2019): 8. http://dx.doi.org/10.25105/livas.v4i1.4625.
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<p>ABSTRACT</p><p>The objective of this study is to clarify the connectivity: spatial and physical patterns of Banjarese Kampungs in South Kalimantan river networks for the community of Rumah Bubungan Tinggi (RBT) or high ridge houses. It provides a basis for potential reconstructing a Banjarese Kampung in keeping with the sociocultural context. We investigated a total of an urban kampung (177 households) and 12 RBT groups (4 RBTs groups in 1 urban kampung and 8 RBT groups in 2 rural kampungs). We describe the development of kampung throughout the evolution of river networks, then analyze the formation of dwelling in the urban kampung and the changing of spatial composition in the kin-group. The discussion on the evolution river network is based on the reconstruction of waterway patterns from the 15th until the mid 20th century. Finally, the kinship interaction reveals the open-ended multifamily boundaries and the changing level of house connectivity such as rival kin-group</p><p>Keywords: Rumah Bubungan Tinggi (RBT) groups, kampung, connectivity, spatial composition, South Kalimantan</p>
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Liu, Gang, Runnan Zhang, Huimin Song, Can Wang, Jinhui Liu e Aijun Liu. "Ts-RBAC: A RBAC model with transformation". Computers & Security 60 (julho de 2016): 52–61. http://dx.doi.org/10.1016/j.cose.2016.03.006.
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Kansagra, Ankit J., Saurabh Dahiya, Chester Andrzejewski, Robert Krushell, Andrew Lehman, Jordan Greenbaum, Alice Ehresman et al. "Blood Management Strategies to Reduce Transfusions after Elective Lower-Extremity Joint Arthroplasty Surgeries: One Tertiary Care Hospital's Early Experience with an Alternative Payment Model - a Total Joint 'Bundle". Blood 128, n.º 22 (2 de dezembro de 2016): 3854. http://dx.doi.org/10.1182/blood.v128.22.3854.3854.
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Abstract Background and objective: Blood loss associated with total lower-extremity joint arthroplasty (TJA) often results in postoperative anemia and need for red blood cell transfusions (RBCT). We report the results of a quality improvement initiative to improve blood management and decrease transfusions in patients undergoing TJA in one tertiary hospital. Methods: Pre and post analysis after the implementation of a multifaceted intervention which included preoperative assessment for anemia, use of tranexamic acid, discouragement of autologous pre-operative blood collection and institution of more restrictive RBCT protocols. The results were stratified into three periods: I - pre-interventional (01/01/2013 -09/30/2013); II - peri-interventional (10/01/2013 -04/30/2014); and III - post-interventional (05/01/2014 -12/31/2014). We used fractional logistic regression with robust standard errors and regression modeling was configured using a segmented, or "piecewise", approach in which slope coefficients in each period were estimated. Results: During the study period 2511 patients underwent surgery. Compared with the pre-intervention period, the total number of RBC units transfused decreased from a total of 587 in the pre- to 107 in the post-intervention period (81.8% decrease). The percentage of patients receiving transfusion declined from 36.7% in pre-implementation period to 8.8% to post-intervention period. Depending upon the costing methodology used, annualized savings in RBC expenditure between time period 1 and 3 ranged from a low of $108,000 using the acquisition cost per unit (~$225/unit) to $480,000 when using activity based costing (~$1000/unit). Mean length of stay (days) and 30-day readmission rates remained stable during the study period. Conclusions: A multidisciplinary approach with proactive involvement of all the interested parties can be successful and sustainable in reducing RBCT and its associated costs, in patients undergoing TJA. Disclosures No relevant conflicts of interest to declare.
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Dickey, E. C., e V. P. Dravid. "Rigid-body translation (RBT) of a NiO-ZrO2(cubic) bicrystal and its implications for interface atomic structure". Proceedings, annual meeting, Electron Microscopy Society of America 54 (11 de agosto de 1996): 116–17. http://dx.doi.org/10.1017/s0424820100163046.
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Any internal interface between two crystalline materials can be described by five macroscopic and three microscopic degrees of freedom. The five macroscopic, or geometric, degrees of freedom describe the relative orientations of the two crystalline lattices and interface plane. For the case of low-energy NiO-ZrO2 boundaries this is defined by the orientation relationship: NiO(111)//ZrO2(100), NiO[110]//ZrO2[010]. The three microscopic degrees of freedom describe the relative in-plane and out-of-plane RBT (Tx,Ty,Tz); these RBTs are geometric mechanisms by which the interface can relax to a low-energy configuration. The combination of these eight degrees of freedom describes completely the bicrystallography. This paper investigates the RBT associated with NiO-ZrO2 interfaces as measured from HREM and Z-contrast images (see fig. 1).
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Piercey, Oliver, Zoe Loh, Joanna Chan, Geoffrey Chong, Andrew Grigg, Steven Cheema, Tania Cushion, Gurjot Gill, Matthew Whybird e Eliza Anne Hawkes. "Ability of routine blood tests (RBTs) in asymptomatic patients (pts) with indolent non-Hodgkin lymphoma (iNHL) to detect relapse or clinically significant disease progression." Journal of Clinical Oncology 37, n.º 15_suppl (20 de maio de 2019): e19027-e19027. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e19027.
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e19027 Background: Pts with iNHL undergo active surveillance to detect disease relapse or progression. International guidelines recommend regular RBTs for surveillance but evidence for this practice is lacking. Methods: We conducted a retrospective analysis of pts aged ≥16 yrs from 2008-17 undergoing routine surveillance at 2 Australian centres for grade 1-3a follicular lymphoma (FL) or marginal zone lymphoma (MZL), to assess the utility of full blood count, lactate dehydrogenase & beta-2-microglobulin to detect progression events; (i.e relapse or progression) or to change management. Abnormal results were defined as acute deviations from local laboratory normal ranges not explained by a concurrent medical condition. Eligible pts were either treatment-naive or had achieved a response to lymphoma-directed therapy, had ≥6 mths follow up and an absence of progression events within 3 mths of prior therapy. Demographic data were collected as well as treatment, follow up appointment (appt) details including presence of signs/symptoms, RBT results, survival status & further therapy. The study was ethically approved. Results: 180 eligible pts (FL:142, MZL:38) underwent 1757 follow up appts (median follow up 38 months). RBTs were done at 83% of appts. 74 progression events occurred in a total of 62 pts; 48/74 (65%) had immediate therapy. 2/74 (3%) were detected by RBTs alone, (both treatment naïve pts); 88% by signs/symptoms & 9% by routine imaging. 20/243 (8%) of abnormal RBTs in asymptomatic pts led to a change in subsequent management (10 had imaging; 8 earlier appts; 2 repeat RBTs alone). The sensitivity & positive predictive value of abnormal RBTs to detect progression events were 39% & 9% respectively. In asymptomatic patients, the number of RBTs required to change management and to detect a progression event were 64 and 644 respectively. Conclusions: RBTs rarely detect clinically significant disease progression or relapse and seldom solely lead to a change in management in asymptomatic pts with iNHL. Clinical signs/symptoms are far more likely to detect progression or relapse. Guidelines should reflect the benefit & risk of RBTs in the clinical setting.
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Ivanov, Vadim, Jean El Cheikh, Catherine Faucher, Sabine Furst, Mohamad Mohty, Patrick Ladaique, Claude Lemarie et al. "The Use of Recombinant Human Erythropoietin (rHuEpo) after Reduced Intensity Conditioning (RIC) Allogeneic Hematopoietic Peripheral Blood Stem Cell Transplantation (ASCT) Reduce Red Blood Cell (RBC) Transfusion Requirements." Blood 108, n.º 11 (16 de novembro de 2006): 2988. http://dx.doi.org/10.1182/blood.v108.11.2988.2988.
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Abstract We previously reported that hemoglobin (Hb) recovery was hastened after RIC ASCT as compared with ASCT after myeloablative conditioning (Transfusion, 44:501–8, 2004). In this setting pretransplant Hb level becomes the major predictive factor for early Hb recovery posttransplant and RBC transfusion (RBCT) requirements. We subsequently reported the efficacy of early rHuEpo administration after RIC ASCT to hasten Hb reconstitution (BMT, 36:901–6, 2005). Here we further confirm the efficacy of early posttransplant administration of rHuEpo after RIC reducing RBC requirements and maintaining high levels of posttransplant Hb in the 2 months following transplant.Forty patients surviving at least 60 days were analyzed. Patients characteristics were as follow: age: 50 (27–64); M/F: 28/12; with myeloid (4), lymphoid (29) or solid (7) malignancies. They received a RIC (Fludarabin (150 mg/m²; Busulfan (8mg/kg) and thymoglobulin (2.5 to 5 mg/kg)) followed with an ASCT (all PBSC) from a HLA identical sibling. Aranesp® (Amgen, France) was started on day 1. The 20 first patients received an infusion of 150 mcg/week while the 20 last patients were subsequently treated with 500 mcg/3 weeks. Aranesp® was administered intravenously when inpatient and subcutaneously when outpatient. Aranesp® administration was sustained until day 60 or when patients reached a Hb level of 140 g/L, whichever occurred first. Overall patients were treated for a median of 7 weeks post transplant. No serious adverse effect or thrombosis episode related to Aranesp® was reported in these patients. This cohort of 40 patients experienced a quicker Hb recovery and lower RBCT requirements than a historical and comparable control group of 27 patients (Day +30 Hb: 114 (94–141) vs. 100 (80–129), p<.0001; patients with 0 or 1 RBCT: 83% vs. 55% (p=.02)). Thirteen of the 40 patients (33%) presented with an Hb level of 120 g/L or more prior to conditioning. Over the first 60 days, these patients received 0 (0–2) RBCT as compared with 1 (0–2) RBCT for patients with a pre-RIC Hb level < 120 g/L (p=.05). On this basis, we hypothesized the interest of increasing Hb level prior to RIC by adequate rHuEpo stimulation. With this perspective, we have treated 13 patients with Aranesp® (500 mcg, SC) 3 weeks prior RIC. Nine of these 13 pts (69%) reached an Hb level of 120 g/L or more on day −7 as compared to 35% in patients not receiving Aranesp ® prior to RIC (p=.04). This indicates that Aranesp® post RIC ASCT is efficient to hasten Hb recovery and decrease RBCTs. In addition, a comprehensive strategy to minimize RBCT in this setting might include pre-transplant stimulation. We will prospectively assess this hypothesis.
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Damiani, Maria Luisa, Elisa Bertino, Barbara Catania e Paolo Perlasca. "GEO-RBAC". ACM Transactions on Information and System Security 10, n.º 1 (fevereiro de 2007): 2. http://dx.doi.org/10.1145/1210263.1210265.
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Rao, K. Rajesh, Ashalatha Nayak, Indranil Ghosh Ray, Yogachandran Rahulamathavan e Muttukrishnan Rajarajan. "Role recommender-RBAC: Optimizing user-role assignments in RBAC". Computer Communications 166 (janeiro de 2021): 140–53. http://dx.doi.org/10.1016/j.comcom.2020.12.006.
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Kim, In-Tae, Kyung-Yong Chung, Kee-Wook Rim e Jung-Hyun Lee. "Dynamic RBAC Model based on OSGi". Journal of the Korea Contents Association 9, n.º 1 (28 de janeiro de 2009): 53–60. http://dx.doi.org/10.5392/jkca.2009.9.1.053.
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Shuriya. B, Shuriya B., e Dr S. Sumathi Dr. S. Sumathi. "Study of an RBAC System". Indian Journal of Applied Research 3, n.º 3 (1 de outubro de 2011): 104–6. http://dx.doi.org/10.15373/2249555x/mar2013/34.
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Bonatti, Piero, Clemente Galdi e Davide Torres. "Event-driven RBAC". Journal of Computer Security 23, n.º 6 (2 de dezembro de 2015): 709–57. http://dx.doi.org/10.3233/jcs-150539.
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Lee, Bong-Hwan, e Hyun-Sug Cho. "Role-based User Access Control with Working Status for u-Healthcare System". KIPS Transactions:PartC 17C, n.º 2 (30 de abril de 2010): 173–80. http://dx.doi.org/10.3745/kipstc.2010.17c.2.173.
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Joshi, Jyoti. "Improved & Extended-RBAC (Jv-RBAC) Model with X.509 Authentication". Computer Science & Engineering: An International Journal 2, n.º 3 (30 de junho de 2012): 57–66. http://dx.doi.org/10.5121/cseij.2012.2305.
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Friedman, Gilberto. "A RBTI é ambiciosa!" Revista Brasileira de Terapia Intensiva 20, n.º 3 (setembro de 2008): vii. http://dx.doi.org/10.1590/s0103-507x2008000300001.
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Cooper, P. F., J. A. Hobson e Carol Findlater. "The use of Reed Bed Treatment Systems in the UK". Water Science and Technology 22, n.º 3-4 (1 de março de 1990): 57–64. http://dx.doi.org/10.2166/wst.1990.0183.
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This paper summarises the British experience of Reed Bed Treatment Systems (RBTS) for sewage treatment over the past three years. It includes a list of the 26 systems which have been built together with their design details including, length, width, slope, media and the loading that they are designed for. Comment is made about the use of soil and gravel growth media. Different inlet and outlet arrangements are described. The alternative propagation and planting methods are reviewed. The paper closes with the performance data from a number of the UK systems. The performance of the British beds indicates that RBT Systems may be adequate for BOD and SS removal but the removal of phosphorus and nitrogen is not as high as predicted elsewhere.
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Lee, Woomyo, Gunhee Lee, Sinkyu Kim e Jungtaek Seo. "SG-RBAC : Role Based Access Control Model for Smart Grid Environment". Journal of the Korea Institute of Information Security and Cryptology 23, n.º 2 (30 de abril de 2013): 307–18. http://dx.doi.org/10.13089/jkiisc.2013.23.2.307.
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Berling, C., C. Lacombe, J. C. Lelièvre, M. Allary e J. Saint-Blancard. "The RBC morphological dependance of the RBC disaggregability". Biorheology 25, n.º 5 (1 de outubro de 1988): 791–98. http://dx.doi.org/10.3233/bir-1988-25506.
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Ivanov, Vadim, Catherine Faucher, Patrick Ladaique, Sabine Furst, Mohamad Mothy, Jean El Cheikh, Thomas Prebet et al. "Early Post-Transplant Administration of Recombinant Erythropoietin Decreases Transfusion Needs and Hastens Haemoglobin Reconstitution in Reduced Intensity Conditioned (RIC) Allogeneic Stem Cell Transplantation (ASCT) for Non-Myeloid Malignancies." Blood 110, n.º 11 (16 de novembro de 2007): 2997. http://dx.doi.org/10.1182/blood.v110.11.2997.2997.
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Abstract We have reported that RBCT needs inversely correlated to the conditioning intensity (Transfusion, 2004). Moreover, Hb level prior to RIC ASCT significantly influenced Hb recovery and RBCT needs (BMT, 2005). These findings invited us to test the hypothesis that post RIC allo SCT might represent an attractive setting for rHuEPO use. Here we analysed RBCT needs in the first 60 days after transplantation in 125 consecutive RIC allo geno-identical sibling PBSC ASCTs treated for lymphoid malignancies (LM) and solid tumours (ST) performed in our institution from 01/2001: age: 48 (23–68) ; M/F: 63/62 ; LM/ST: 96/39; RIC: FBA (Fludarabine (FLU)+ Busulfan (BU) + Thymoglobulin (ATG))(74), FBTLI (FLU + BU + 1 Gy TLI) (23), FLU+ 2 Gy TBI (26), FLU + Endoxan (2). 45 pts were treated with rHuEPO started on day 1 (EPO+ group). First 10 pts received epoetine-beta (Neorecormon, Roche) (10.000 IU × 3/week). The remaining 35 pts received Darbopoietine alpha (Aranesp, Amgen), (150 mkg/week: 10 pts; 500 mkg/3 weeks: 25 pts). Trt was continued until Hb level reached 12 g/dL or day +60. 80 pts did not receive EPO stimulation (EPO- group). There were no significant differences between the 2 groups in terms of patient and graft characteristics. AGVHD grade II–IV appeared before day +60 in both groups in 36% of cases. The 4 year survival probability estimates did not differ between the 2 groups (EPO+: 49.7% (32–67); EPO-: 44.7% (32–60)). Potential risk factors for RBCT needs were assessed in a univariate analysis: patient and donor age (NS), patient and donor gender (NS), donor/recipient gender compatibility (NS), ABO compatibility (NS), diagnosis (lymphoid malignancies vs solid tumours (NS)), conditioning regiments (ATG-based vs no ATG (NS) and BU-containing vs. no BU (NS)), CD34+ cell dose (<6 ×106/kg vs. ≥6 ×106/kg) (NS), Hb level prior to conditioning (Hb < 12 g/dl vs. Hb ≥ 12 g/dL (p<0.005)) and rHuEPO use (Y vs N (p<0.02)). In a multivariate analysis, Hb level (Hb < 12 g/dl vs Hb ≥ 12 g/dL; p=0.0001) and rHuEPO use (EPO+ vs EPO-; p=0.0096) independently influenced RBCT needs. The cohort of 45 EPO+ pts experienced a quicker Hb recovery allowing patients lo leave the “anaemic” zone associated with higher fatigue on day 20 (Fig) and significantly lower RBCT needs (EPO+ group: 1.8±0.3 RBC units; EPO- group 3.3±0.4 units (p<0.02)). In conclusion, in pts grafted with RIC the use of early rHuEPO is associated with a significant reduction of RBCT needs and has a major positive impact on early Hb recovery potentially limiting the fatigue syndrome post-transplant. This data provide proof of principle and rational of starting the rHuEPO early after RIC transplantation. Figure: Post graft Hb level evolution (mean ± SEM): group EPO+ (plain curve) vs. group EPO- (dashed curve). Figure Figure
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Liu, Kui, Zhurong Zhou, Qianguo Chen e Xiaoli Yang. "Towards a RBAC Workflow Model for Thesis Management". Journal of Software 10, n.º 4 (abril de 2015): 480–90. http://dx.doi.org/10.17706/jsw.10.4.480-490.
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Hwang, Jeong-Hee, Moon-Sun Shin, Jong-Yun Lee e Ik-Soo Hwang. "RBAC Based Security Model for International Logistic Service". KIPS Transactions:PartC 16C, n.º 3 (30 de junho de 2009): 307–16. http://dx.doi.org/10.3745/kipstc.2009.16-c.3.307.
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Lu, Haibing, Yuan Hong, Yanjiang Yang, Lian Duan e Nazia Badar. "Towards user-oriented RBAC model". Journal of Computer Security 23, n.º 1 (15 de março de 2015): 107–29. http://dx.doi.org/10.3233/jcs-140519.
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Chen, Hsing-Chung, Marsha Anjanette Violetta e Cheng-Ying Yang. "Contract RBAC in cloud computing". Journal of Supercomputing 66, n.º 2 (1 de outubro de 2013): 1111–31. http://dx.doi.org/10.1007/s11227-013-1017-5.
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Habib, Muhammad Asif, e Qaisar Abbas. "Mutually exclusive permissions in RBAC". International Journal of Internet Technology and Secured Transactions 4, n.º 2/3 (2012): 207. http://dx.doi.org/10.1504/ijitst.2012.047962.
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