Bibliografias temáticas / Recepteur immunoglobuline g

Literatura científica selecionada sobre o tema "Recepteur immunoglobuline g"

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Publicado: 20 de abril de 2024

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Artigos de revistas sobre o assunto "Recepteur immunoglobuline g":

1

Fridén, Barbro E., Ricardo Makiya, Berith M. Nilsson, Stig Holm e Torgny I. Stigbrand. "The human placental immunoglobulin G receptor and immunoglobulin G transport". American Journal of Obstetrics and Gynecology 171, n.º 1 (julho de 1994): 258–63. http://dx.doi.org/10.1016/0002-9378(94)90479-0.

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Campos-Neto, Antonio, Isabelle Suffia, Karen A. Cavassani, Shyian Jen, Kay Greeson, Pamela Ovendale, João S. Silva, Steven G. Reed e Yasir A. W. Skeiky. "Cloning and Characterization of a Gene Encoding an Immunoglobulin-Binding Receptor on the Cell Surface of Some Members of the Family Trypanosomatidae". Infection and Immunity 71, n.º 9 (setembro de 2003): 5065–76. http://dx.doi.org/10.1128/iai.71.9.5065-5076.2003.

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ABSTRACT Several members of the Trypanosomatidae family, when freshly isolated from their mammalian hosts, have immunoglobulins adsorbed to their cell surfaces. However, a significant portion of these antibody molecules is not parasite specific, i.e., the immunoglobulins are bound to the parasite's cell surface molecules via noncognitive interactions. It has been proposed that this noncognitive adsorption of immunoglobulins to the parasite is mediated by an Fc-like receptor present in several members of the Trypanosomatidae family. However, the molecular identification of this receptor has never been defined. Here, we describe the cloning of a gene encoding a protein that might represent this molecule. The gene, named Lmsp1, was cloned by screening a Leishmania major cDNA expression library using a rabbit antiserum. Lmsp1 is present in both Leishmania and Trypanosoma and is expressed in all developmental stages of these parasites. The predicted protein has a molecular mass of 16.6 kDa and contains an RGD sequence starting at residue 104 and three cysteine residues at positions 55, 74, and 116. The purified recombinant protein strongly binds to normal immunoglobulins of various animal species (humans, rabbits, sheep, goats, guinea pigs, donkeys, rats, and mice) and the binding to human immunoglobulins appears to be immunoglobulin G (IgG) and IgM isotype specific. Moreover, Lmsp1 binds to both purified Fc and Fab fragments of IgG from both humans and rabbits. The mapping of the Lmsp1 epitopes that bind human IgG revealed that different sequences of the molecule bind to Fc or Fab. In addition, fluorescence-activated cell sorter analyses with a specific rabbit anti-Lmsp1 antiserum showed that Lmsp1 is associated with the parasite's cell surface. Finally, inhibition experiments point to an active role of this molecule in the immunoglobulin-mediated attachment and penetration of Trypanosoma cruzi in its macrophage host cells, thus suggesting that Lmsp1 is a putative Trypanosomatidae immunoglobulin receptor.
3

Hansen, Gert H., Lise-Lotte Niels-Christiansen, Lissi Immerdal e E. Michael Danielsen. "Antibodies in the small intestine: mucosal synthesis and deposition of anti-glycosyl IgA, IgM, and IgG in the enterocyte brush border". American Journal of Physiology-Gastrointestinal and Liver Physiology 291, n.º 1 (julho de 2006): G82—G90. http://dx.doi.org/10.1152/ajpgi.00021.2006.

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Synthesis and deposition of immunoglobulins in the brush border was studied in organ-cultured pig small intestinal mucosal explants. Surprisingly, comparable amounts of IgM and IgA were synthesized during a 6-h pulse, and also newly made IgG was detected in media and explants, including the microvillar fraction. For IgA and IgM, this subcellular distribution is consistent with basolateral-to-apical transcytosis, mediated by the polymeric immunoglobulin receptor. IgG is a ligand for the Fc receptor FcRn, and β2-microglobulin, the light chain of FcRn, coclustered in immunogold double labeling with IgG in subapical endosomes and in the basolateral membrane of enterocytes. In addition, β2-microglobulin was copurified with IgG on protein G-Sepharose. Apical endocytosis of IgG, as judged by internalization of fluorescent protein G, was not detectable except in a few isolated cells. This suggests that IgG in the adult small intestine is transported across the enterocyte mainly in the basolateral to apical direction. Significant fractions of all immunoglobulins bound to lactoseagarose, indicating that “anti-glycosyl” antibodies, raised against commensal gut bacteria, are synthesized locally in the small intestine. By partial deposition in the brush border, these antibodies therefore may have a protective function by preventing lectin-like pathogens from gaining access to the brush border surface.
4

Peng, Xu, Xiao-Bi Xie, Hong Tan, Dan Zhang, Bo-Tao Jiang, Jie Liu, Shuang Li, Ya-Rui Chen e Tao-Yang Xie. "Effects of Plasma Exchange Combined with Immunoglobulin Therapy on Consciousness, Immune Function, and Prognosis in Patients with Myasthenia Gravis Crisis: A Prospective Randomized Test". Computational and Mathematical Methods in Medicine 2022 (30 de junho de 2022): 1–7. http://dx.doi.org/10.1155/2022/7796833.

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Background. Myasthenia gravis (MG) is an acquired autoimmune disease. The main clinical features of MG are skeletal muscle fatigue and pathological fatigue, which worsen at night or after fatigue, such as dyspnea, dysphagia, and systemic weakness. Plasma exchange (PE) is often used in patients with acute exacerbation of MG. Intravenous immunoglobulin (IVIG) is a collection of immunoglobulins from thousands of donors. IVIG can replace a variety of immunosuppressants or PE. However, the effect of PE or IVIG on patients’ consciousness, immune function, and prognosis is not clear. Objective. A prospective randomized test of the effects of PE combined with immunoglobulin on consciousness, immune function, and prognosis in patients with myasthenia gravis crisis (MGC). Methods. Sixty patients with MGC treated from February 2019 to April 2021 were enrolled in our hospital. The cases who received PE were set as the PE group, and those who received PE combined with immunoglobulin were set as the PE+immunoglobulin group. The efficacy, clinical score, state of consciousness, immune function, acetylcholine receptor antibody (AChR-Ab), lymphocyte (LYM), albumin (ALB) levels, and the incidence of adverse reactions were compared. Results. The improvement rate was 100.005% in the treatment group and 83.33% in the PE group. After treatment, the clinical score of the PE+immunoglobulin group was lower than that of the PE group, and the clinical relative score of the PE+immunoglobulin group was higher than that of the PE group ( P < 0.05 ). The number of conscious people in the PE+immunoglobulin group was more than that in the PE group ( P < 0.05 ). Immunoglobulin A, immunoglobulin M, immunoglobulin G, and immunoglobulin G in the PE+immunoglobulin group were higher than those in the PE group ( P < 0.05 ). The levels of AChR-Ab and ALB in the PE+immunoglobulin group were higher than those in the PE group, while the level of LYM in the PE+immunoglobulin group was lower than that in the PE group. The incidence of skin system, gastrointestinal system, nervous system, and systemic damage in the PE+immunoglobulin group was lower than that in the PE group ( P < 0.05 ). Conclusion. The treatment of MGC with PE combined with immunoglobulin can not only effectively enhance the consciousness and immune function of patients but also effectively promote the prognosis, and the safety of treatment can be guaranteed.
5

Steiner, M., e E. F. Lüscher. "Identification of the immunoglobulin G receptor of human platelets." Journal of Biological Chemistry 261, n.º 16 (junho de 1986): 7230–35. http://dx.doi.org/10.1016/s0021-9258(17)38379-5.

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Nakamura, Kazuhiro, Hirokazu Hirai, Takashi Torashima, Taisuke Miyazaki, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji et al. "CD3 and Immunoglobulin G Fc Receptor Regulate Cerebellar Functions". Molecular and Cellular Biology 27, n.º 14 (14 de maio de 2007): 5128–34. http://dx.doi.org/10.1128/mcb.01072-06.

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ABSTRACT The immune and nervous systems display considerable overlap in their molecular repertoire. Molecules originally shown to be critical for immune responses also serve neuronal functions that include normal brain development, neuronal differentiation, synaptic plasticity, and behavior. We show here that FcγRIIB, a low-affinity immunoglobulin G Fc receptor, and CD3 are involved in cerebellar functions. Although membranous CD3 and FcγRIIB are crucial regulators on different cells in the immune system, both CD3ε and FcγRIIB are expressed on Purkinje cells in the cerebellum. Both CD3ε-deficient mice and FcγRIIB-deficient mice showed an impaired development of Purkinje neurons. In the adult, rotarod performance of these mutant mice was impaired at high speed. In the two knockout mice, enhanced paired-pulse facilitation of parallel fiber-Purkinje cell synapses was shared. These results indicate that diverse immune molecules play critical roles in the functional establishment in the cerebellum.
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Hibbs, M. L., L. Bonadonna, B. M. Scott, I. F. McKenzie e P. M. Hogarth. "Molecular cloning of a human immunoglobulin G Fc receptor." Proceedings of the National Academy of Sciences 85, n.º 7 (1 de abril de 1988): 2240–44. http://dx.doi.org/10.1073/pnas.85.7.2240.

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Luzi, G., e R. Ferrara. "Immunoregulation of Autoimmune Disorders: The Role of Intravenous Immunoglobulins". International Journal of Artificial Organs 16, n.º 5_suppl (maio de 1993): 189–95. http://dx.doi.org/10.1177/039139889301605s43.

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Modified and intact immunoglobulin preparations are available for therapeutic use. The administration of intravenous immunoglobulins (IVI G) gave positive results in Primary Immunodeficiency Syndromes (PIS) (prophylaxis of viral and bacterial diseases), in treatment of secondary immunodeficiencies (hematologic malignancies, bone marrow transplantation), and in some infections. Adverse reactions have been reported during IVIG infusions, but they are rarely serious and do not represent limiting conditions for a short or long term therapy. After the original observation in thrombocytopenic purpura, IVIG have been used as immune modulators in various autoimmune related disorders. Various mechanisms of action are proposed: blockade and down regulation of phagocytic function via Fc receptor, regulation of idiotype-anti idiotype network, suppression of idiotype synthesis, T-B cell interference towards antigen presentation, increase in suppressor lymphocytes, IVIG-cytokine interaction.
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Lindroos, Jenny Linnea Victoria, Marte-Helene Bjørk e Nils Erik Gilhus. "Transient Neonatal Myasthenia Gravis as a Common Complication of a Rare Disease: A Systematic Review". Journal of Clinical Medicine 13, n.º 4 (17 de fevereiro de 2024): 1136. http://dx.doi.org/10.3390/jcm13041136.

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Myasthenia gravis (MG) is a rare autoimmune disease. Transient neonatal myasthenia gravis (TNMG) is caused by pathogenic maternal autoantibodies that cross the placenta and disrupt signaling at the neuromuscular junction. This is a systematic review of this transient immunoglobulin G (IgG)-mediated disease. TNMG affects 10–20% of children born to mothers with MG. The severity of symptoms ranges from minor feeding difficulties to life-threatening respiratory weakness. Minor symptoms might go unnoticed but can still interfere with breastfeeding. Acetylcholine-esterase inhibitors and antibody-clearing therapies such as immunoglobulins can be used to treat TNMG, but most children do well with observation only. TNMG is self-limiting within weeks as circulating antibodies are naturally cleared from the blood. In rare cases, TNMG is associated with permanent skeletal malformations or permanent myopathy. The mother’s antibodies can also lead to spontaneous abortions. All healthcare professionals meeting pregnant or birthing women with MG or their neonates should be aware of TNMG. TNMG is hard to predict. Reoccurrence is common among siblings. Pre-pregnancy thymectomy and intravenous immunoglobulins during pregnancy reduce the risk. Neonatal fragment crystallizable receptor (FcRn) blocking drugs for MG might reduce TNMG risk.
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Ramos-Martínez, Ivan, Edgar Ramos-Martínez, Marco Cerbón, Armando Pérez-Torres, Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Margarito Martínez-Cruz et al. "The Role of B Cell and T Cell Glycosylation in Systemic Lupus Erythematosus". International Journal of Molecular Sciences 24, n.º 1 (3 de janeiro de 2023): 863. http://dx.doi.org/10.3390/ijms24010863.

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Glycosylation is a post-translational modification that affects the stability, structure, antigenicity and charge of proteins. In the immune system, glycosylation is involved in the regulation of ligand–receptor interactions, such as in B-cell and T-cell activating receptors. Alterations in glycosylation have been described in several autoimmune diseases, such as systemic lupus erythematosus (SLE), in which alterations have been found mainly in the glycosylation of B lymphocytes, T lymphocytes and immunoglobulins. In immunoglobulin G of lupus patients, a decrease in galactosylation, sialylation, and nucleotide fucose, as well as an increase in the N-acetylglucosamine bisector, are observed. These changes in glycoisolation affect the interactions of immunoglobulins with Fc receptors and are associated with pericarditis, proteinuria, nephritis, and the presence of antinuclear antibodies. In T cells, alterations have been described in the glycosylation of receptors involved in activation, such as the T cell receptor; these changes affect the affinity with their ligands and modulate the binding to endogenous lectins such as galectins. In T cells from lupus patients, a decrease in galectin 1 binding is observed, which could favor activation and reduce apoptosis. Furthermore, these alterations in glycosylation correlate with disease activity and clinical manifestations, and thus have potential use as biomarkers. In this review, we summarize findings on glycosylation alterations in SLE and how they relate to immune system defects and their clinical manifestations.
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Artigos de revistas

Teses / dissertações sobre o assunto "Recepteur immunoglobuline g":

1

D'ACREMONT, GEFFRIER CHRISTINE. "Recepteur de faible affinite pour le fragment fc des immunoglobulines g (recepteur fc gamma de type iii) : mise en evidence de la forme soluble circulante dans le plasma humain". Nantes, 1989. http://www.theses.fr/1989NANT030M.

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Durand, Véronique. "Etude du rôle des récepteurs de type III pour le Fc des IgG : effets regulateurs des auto-anticorps correspondants dans l'auto-immunité (doctorat : immunologie)". Brest, 2000. http://www.theses.fr/2000BRES3100.

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Behr-Gross, Esposito-Farese Marie-Emmanuelle. "Etude de la fonction de trois marqueurs des cellules de Langerhans épidermiqueS : le granule de Birbeck, les molécules CD1 et les récepteurs pour la partie Fc des immunoglobulines G". Strasbourg 1, 1995. http://www.theses.fr/1995STR15067.

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Blank, Ulrich. "Caracterisation biochimique et purification des immunoglobulin-g-binding factors (igg-bf) murins". Paris 7, 1987. http://www.theses.fr/1987PA077005.

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Les lymphocytes t, porteurs de recepteurs fc, produisent des facteurs de liaison d'immunoglobuline g (igg-bf) qui se lient a la fraction fc des igg et suppriment leur production par les lymphocytes b. L'igg-bf apparait heterogene en poids moleculaire et en charge. Il est n- et o-glycosyli. A l'aide de l'anticorps monoclonal anti-rf::(c)gamma , 2-4g2, il a ete etabli que l'igg-bf porte des sites antigeniques commun avec le rfcgamma , un dosage radioimmunologique a ete developpe sur nitrocellulose. Apres differentes etapes de purification par chromatographie, l'heterogeneite a ete confirmee
5

Cameron, Angus James MacGregor. "Molecular mechanisms governing Fc#gamma# receptor mediated signal transduction". Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340327.

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Varin-Blank, Nadine. "ANALYSE STRUCTURALE ET FONCTIONNELLE DE RECEPTEURS POUR LA PARTIE Fc DES IMMUNOGLOBULINES G ET E". Paris 6, 1990. http://www.theses.fr/1990PA066707.

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Les lymphocytes t de souris exprimant le rfc gamma 2 membranaire regulent a distance la production des immunoglobulines par l'intermediaire de facteurs solubles, les immunoglobulin-binding factors qui pourraient correspondre a des formes solubles de ces recepteurs. L'expression de rfc gamma b1 recombinant dans des fibroblastes a permis de caracteriser un mecanisme de clivage proteolytique du recepteur membranaire. La molecule soluble produite represente le domaine extracytoplasmique du recepteur. D'autre part, un recepteur soluble, obtenu par mutagenese dirigee, correspondant egalement au domaine extracytoplasmique du recepteur, a reproduit l'activite regulatrice des immunoglobulin binding factors. Le rfc gamma 1 des cellules mastocytaires et des basophiles initie, apres agregation, l'activation cellulaire aboutissant au relargage de mediateurs responsables des symptomes allergiques. Nous avons developpe un systeme d'etude reproduisant les evenements biochimiques precoces de la transduction du signal apres transfection des adnc codant pour les 3 sous-unites du recepteur (alpha, beta, gamma 2) dans des mastocytes rfc epsilon 1-negatifs. A l'aide de mutants des 3 sous-unites, transfectes dans des cellules cos, nous avons montre que les zones de contact direct dans le complexe sont portees par les domaines transmembranaires. Ces domaines presentent une asymetrie au niveau de leur hydropathicite pouvant faciliter le contact entre les residus plus hydrophiles a l'interieur de la bicouche lipidique. Nous avons aussi etabli l'existence d'un seul pont disulfure au niveau des cysteines 7 entre le dimere de chaines gamma
7

Chesla, Scott Edward. "Two dimensional (solid phase) kinetic analysis of FCnGamma receptor III (CD16) Interactions with IgG". Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-04042005-154037/.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2005.
Dr. Cheng Zhu, Committee Chair ; Dr. Periasamy Selvaraj, Committee Co-Chair ; Dr. Timothy Wick, Committee Member ; Dr. Lyle Sinor, Committee Member ; Dr. Raymond Vito, Committee Member ; Dr. Robert Nerem, Committee Member.
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Bonnerot, Christian. "Bases structurales de la diversite fonctionnelle des recepteurs murins de basse affinite pour la portion fc des immunoglobulines g". Paris 7, 1992. http://www.theses.fr/1992PA077026.

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Les cellules du systeme immunitaire expriment, voire coexpriment, trois formes de recepteurs pour les igg complexees. Pour aborder l'etude des bases structurales de la diversite fonctionnelle de ces recepteurs a la surface de cellules du systeme immunitaire, nous avons choisi d'exprimer les trois formes de recepteurs dans le lymphome b iia1. 6. Le modele experimental que nous avons construit, nous a permis d'etudier differentes fonctions des recepteurs de type 2 et 3 de faible affinite et particulierement dans les lymphocytes b. Le recepteur de type 3 est le seul recepteur capable de declencher directement l'activation cellulaire, alors que les deux isoformes du recepteur de type 2 bloquent l'activation de lymphocyte b quand elles sont pontees aux migg. L'isoforme b2 du recepteur de type 2 et le recepteur de type 3 internalisent des complexes immuns et ainsi facilitent la presentation d'un ag. Les structures responsables de ces differentes activites ont toutes ete localisees dans la region intracytoplasmique de ces recepteurs. Cette etude donne les bases moleculaires de la specificite fonctionnelle des recepteurs pour la portion fc des immunoglobulines g dans un lymphome b murin, et permet de mieux comprendre le role de ces recepteurs au sein du systeme immunitaire ainsi que les mecanismes cellulaires qui determinent leurs differentes activites
9

PEREZ, CHRISTOPHE. "Etude de la regulation transcriptionnelle par l'interferon gamma du gene humain codant pour le recepteur de haute affinite aux immunoglobulines g dans les cellules myeloides". Paris 6, 1995. http://www.theses.fr/1995PA066692.

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Afin de mieux comprendre les mecanismes moleculaires impliques dans le phenomene d'activation des cellules myelomonocytaires nous avons choisi d'etudier la regulation transcriptionnelle du gene humain codant pour le recepteur de haute affinite pour le fragment fc des immunoglobulines g (fcgri ou cd64). Ce gene est specifiquement induit par l'interferon gamma (ifn g) et ce uniquement dans les cellules d'origine myeloide. L'etude du promoteur a permis l'identification des deux sequences gire (gamma interferon responsive element) et mate (myeloid activating transcription element) impliquees respectivement dans la reponse a l'ifn g et dans la restriction de l'expression aux cellules myeloides. Ces motifs sont reconnus par differents facteurs de transcription avec lesquels ils forment respectivement les complexes gire-bp et mate-bp. Alors que le premier est active par l'ifn g dans differents types cellulaires, le second n'est present que dans les lignees cellulaires myeloides et lymphocytaires b. L'analyse d'extraits de mutants cellulaires, defectifs dans leur reponse aux ifns, a montre que gire-bp contient la proteine p91 ou stat1, deja connue comme faisant partie du complexe isgf3 activable par les ifns alpha et beta. Contrairement a isgf3 dont la formation depend du couple de tyrosines kinases jak1 et tyk-2, l'activation de gire-bp qui est constitue de l'homodimere phosphoryle de stat1 implique les tyrosines kinases jak1 et jak2. Le facteur de transcription reconnaissant le motif mate a ete identifie comme etant le protooncogene pu. 1/spi-1, present exclusivement dans les cellules myeloides et lymphocytaires b. La seule expression de ce facteur dans des cellules non hematopoietiques restore l'activation d'un gene rapporteur sous controle des sequences gire et mate. L'activite mate-bp peut etre detectee sous la forme de differents complexes mate-bp1,-bp2,-bp3. Si mate-bp1 depend de l'association de pu. 1/spi-1 avec le motif mate, les deux autres complexes proviennent d'une proteolyse in vitro de ce meme facteur lors de la preparation des extraits cellulaires. L'ensemble de ces observations nous a permis de mettre en evidence une modulation de l'expression de proteases selon les conditions de culture et l'etat de differenciation des cellules de type myelomonocytaire
10

Martin, Warham Lance. "Protein-protein recognition: The neonatal Fe receptor and immunoglobulin G". Thesis, 2001. https://thesis.library.caltech.edu/8116/8/Martin%202001.pdf.

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The neonatal Fe receptor (FeRn) binds the Fe portion of immunoglobulin G (IgG) at the acidic pH of endosomes or the gut and releases IgG at the alkaline pH of blood. FeRn is responsible for the maternofetal transfer of IgG and for rescuing endocytosed IgG from a default degradative pathway. We investigated how FeRn interacts with IgG by constructing a heterodimeric form of the Fe (hdFc) that contains one FeRn binding site. This molecule was used to characterize the interaction between one FeRn molecule and one Fe and to determine under what conditions FeRn forms a dimer. The hdFc binds one FeRn molecule at pH 6.0 with a K_d of 80 nM. In solution and with FeRn anchored to solid supports, the heterodimeric Fe does not induce a dimer of FeRn molecules. FcRnhdFc complex crystals were obtained and the complex structure was solved to 2.8 Å resolution. Analysis of this structure refined the understanding of the mechanism of the pH-dependent binding, shed light on the role played by carbohydrates in the Fe binding, and provided insights on how to design therapeutic IgG antibodies with longer serum half-lives. The FcRn-hdFc complex in the crystal did not contain the FeRn dimer. To characterize the tendency of FeRn to form a dimer in a membrane we analyzed the tendency of the hdFc to induce cross-phosphorylation of FeRn-tyrosine kinase chimeras. We also constructed FeRn-cyan and FeRn-yellow fluorescent proteins and have analyzed the tendency of these molecules to exhibit fluorescence resonance energy transfer. As of now, neither of these analyses have lead to conclusive results. In the process of acquiring the context to appreciate the structure of the FcRn-hdFc interface, we developed a study of 171 other nonobligate protein-protein interfaces that includes an original principal component analysis of the quantifiable aspects of these interfaces.

Capítulos de livros sobre o assunto "Recepteur immunoglobuline g":

1

Terje Andersen, Jan, e Inger Sandlie. "Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design". In Drug Delivery in Oncology, 85–120. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634057.ch4.

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Dimmock, Nigel J. "Immunoglobulin G Neutralization Mechanisms Which Operate After Attachment of Virus—Antibody Complex to a Cell Receptor Unit". In Current Topics in Microbiology and Immunology, 17–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77849-0_5.

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"CD16 (FcγRIII, immunoglobulin G [IgG] Fc receptor III)". In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 286. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_2479.

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McKeon, Andrew. "Rapidly Progressive Gait and Coordination Difficulties". In Mayo Clinic Cases in Neuroimmunology, editado por Andrew McKeon, B. Mark Keegan e W. Oliver Tobin, 111–12. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0034.

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A 59-year-old woman noted sudden onset of slurred speech. Within a few days, she noted double vision, gait unsteadiness, and incoordination of her limbs. She sought care at her local emergency department. Computed tomography and magnetic resonance imaging of the head were negative for stroke. Her symptoms persisted. Neurologic examination indicated a moderate pancerebellar ataxia, without additional abnormalities. Her pursuit eye movements were saccadic. She had binocular diplopia with horizontal, gaze-evoked nystagmus. She had ataxic dysarthria and dysmetria of all limbs. Her steps and walking were irregular and she could not accomplish tandem gait. Additional neural antibody testing was undertaken, beyond the classic paraneoplastic antibodies. Metabotropic glutamate receptor 1-immunoglobulin G was detected in the serum and cerebrospinal fluid. The patient was diagnosed with autoimmune cerebellar ataxia. Because of the reported association of metabotropic glutamate receptor 1-immunoglobulin G with Hodgkin disease and non-Hodgkin lymphoma, positron emission tomography–computed tomography of the trunk (orbits to thighs) was performed, which was negative. After 6 weeks of intravenous methylprednisolone, the patient returned for evaluation. She had a mild ataxic dysarthria and minimal dysmetria of her left upper extremity only. She could tandem walk almost without error, and her gait appeared normal (no longer broad-based). At that point, immunotherapy was discontinued. At last follow-up, her neurologic examination findings remained stable. The subacute onset and rapid progression of ataxic symptoms in this adult patient led to suspicion for an autoimmune cause.
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Kunchok, Amy C., e Eoin P. Flanagan. "Rapidly Progressive Dementia and Thyroid Antibodies". In Mayo Clinic Cases in Neuroimmunology, editado por Andrew McKeon, B. Mark Keegan e W. Oliver Tobin, 93–95. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0028.

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A 70-year-old woman sought care for subacute cognitive decline. She initially began to get lost in familiar places. She also reported multiple episodes of hot flashes accompanied by an unusual abdominal sensation that lasted 90 seconds each, which were suspicious for sensory seizures. After symptom onset, her cognition rapidly deteriorated over the subsequent 6 weeks such that she had difficulty with activities of daily living. On neural autoantibody testing, serum and cerebrospinal fluid were positive for α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor immunoglobulin G autoantibody by tissue-based indirect immunofluorescence assay, which was molecularly confirmed by α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor–specific cell-based assay. Because of the paraneoplastic significance of α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor–immunoglobulin G, a comprehensive search for cancer followed. 18F-Fludeoxyglucose positron emission tomography-computed tomography of the body demonstrated increased 18F-fludeoxyglucose uptake (hypermetabolism) in the right hilum and numerous mediastinal lymph nodes, suggestive of malignancy. Dedicated positron emission tomography-computed tomography brain imaging demonstrated generalized atrophy, without abnormal uptake. Bronchoscopy with lymph node biopsy was undertaken. Small cell carcinoma of the lung was found on histopathologic analysis. The patient was diagnosed with paraneoplastic autoimmune dementia in the setting of α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor autoantibodies and stage IIIB small cell carcinoma of the lung. The metastatic small cell carcinoma of the lung was treated with chemotherapy (carboplatin and etoposide) and radiation, with disease resolution. For her cognitive symptoms, she was given intravenous methylprednisolone, with resolution of symptoms. An insidious onset of cognitive decline in older persons is suggestive of a neurodegenerative dementia. However, a rapidly progressive dementia or a subacute or fluctuating course should raise suspicion for an autoimmune/paraneoplastic cause, which is critical to identify given the potential for reversibility.
6

Ladoyanni, Evmorfia. "Chronic Spontaneous Urticaria – Diagnosis and Management". In Urticaria - Diagnosis and Management [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97646.

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Chronic urticaria can be subclassified into chronic spontaneous urticaria and chronic inducible urticaria. Up to 30% of cases are associated with functional immunoglobulin G antibodies to the high affinity immunoglobulin E receptor FcεRIα or to immunoglobulin A. Pathogenic activation of mast cells and basophils gives rise to release of pro-inflammatory mediators that lead to development of hives. CSU is a debilitating disease with a relapsing course. It affects 0.5–1% of the population at any given time. The duration of CSU is generally 1–5 years but can be longer in cases associated with angioedema and autoreactivity. CSU has detrimental effects on life quality with sleep-deprivation and psychiatric disorders being the most frequent. In a great number of patients an underlying cause or eliciting factor cannot be identified. Among the patients in which an aetiology is suspected, infections, medication, food and psychological factors are most commonly associated. A potential autoimmune cause has been reported in up to 50% of patients. Chronic inducible urticaria is characterised by its ability to be triggered consistently and reproducibly in response to a specific stimulus (pressure, temperature, vibration, water, heat, light). Antihistamines form the mainstay of therapy. In recalcitrant chronic urticaria, a variety of other drugs have been tried.
7

Devine, Michelle F., e A. Sebastian Lopez Chiriboga. "Stiffness, Spasms, and Frequent Falls in a 41-Year-Old Man". In Mayo Clinic Cases in Neuroimmunology, editado por Andrew McKeon, B. Mark Keegan e W. Oliver Tobin, 118–19. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0037.

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A 41-year-old man sought care for 3 years of right-sided muscle stiffness. He also had 5- to 10-minute episodes of severe muscle spasms. He noted development of daily episodes of sudden, severe stiffness, often triggered by unexpected stimuli (eg, a touch or loud sound). He started using a walker and stopped driving. He stopped working because of increasing difficulty with mobility and cognition. On neurologic examination, he had a Kokmen Short Test of Mental Status score of 28/38, with points lost for orientation, attention, calculation, and recall. Cranial nerve examination showed bilateral ptosis and hypometric saccadic eye movements. He had normal strength but diffuse rigidity with increased tone, most severe in the right lower extremity. Magnetic resonance imaging of the brain indicated right parietal postoperative changes (post hematoma evacuation). Electroencephalography showed dysrhythmia grade 1 over the right frontotemporal region (above the prior hematoma). Cerebrospinal fluid was inflammatory, with mildly increased protein concentration and supernumerary oligoclonal bands. Movement laboratory evaluation demonstrated an exaggerated startle and abnormal exteroceptive response consistent with central nervous system hyperexcitability. Neural-specific autoantibody testing was positive for glycine receptor α‎1 subunit-immunoglobulin G in both serum and cerebrospinal fluid. He was diagnosed with progressive encephalomyelitis with rigidity and myoclonus with positive glycine receptor α‎1 subunit-immunoglobulin G. Given the immune-mediated cause of progressive encephalomyelitis with rigidity and myoclonus, he was started on intravenous methylprednisolone and concurrent rituximab. The patient markedly improved. His anxiety was still severe, however, and required increased escitalopram and cognitive behavioral therapy to control. He was tapered off intravenous methylprednisolone and maintained on rituximab. His symptoms eventually resolved. He remained stable at 2-year follow-up after initiating immunosuppression. Progressive encephalomyelitis with rigidity and myoclonus is considered a variant of stiff-person syndrome. There is clinical overlap between progressive encephalomyelitis with rigidity and myoclonus and classic stiff-person syndrome, which are both characterized by central nervous system hyperexcitability with exaggerated startle, muscle rigidity, and painful spasms.
8

Devine, Michelle F., e Sean J. Pittock. "Constipation and Syncope". In Mayo Clinic Cases in Neuroimmunology, editado por Andrew McKeon, B. Mark Keegan e W. Oliver Tobin, 143–45. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0046.

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A 43-year-old woman sought care for severe constipation associated with syncopal episodes. Her constipation alternated with explosive diarrhea. Chronic left-sided abdominal pain and severe bloating developed after eating. She was diagnosed with irritable bowel syndrome. After the initial onset of symptoms, nausea, bloating, and intractable vomiting developed. Symptoms were exacerbated by food and were partially relieved with vomiting. She had multiple episodes of bilious, undigested emesis per day. Trials of antiemetics and motility agents provided no substantial relief. She adopted a liquid diet, avoided solid foods, and eventually had a gastrostomy tube placed. She lost at least 15.9 kg over 2 years. Review of systems was significant for generalized fatigue and a burning sensation in her hands and feet. Her medical history was pertinent for Graves disease previously treated with remote thyroid radioablation, and she was now taking thyroid hormone replacement therapy. Neurologic examination findings were normal except for unreactive pupillary light reflexes. A gastrointestinal tract transit study showed persistently delayed colonic transit with mildly delayed gastric emptying. Autonomic reflex screening showed diffuse postganglionic sympathetic sudomotor, severe cardiovagal, and severe cardiovascular adrenergic impairment. Thermoregulatory sweat testing showed diffuse anhidrosis. Creatinine value was mildly increased. The serum was strongly positive for ganglionic (alpha 3) acetylcholine receptor-immunoglobulin G. The findings strongly suggested an autonomic autoimmune polyganglionopathy, with autoimmune gastrointestinal dysmotility as the predominant phenotype. She received intravenous immunoglobulin. She had complete resolution of her previous constipation, nausea, and vomiting. She regained 22.7 kg. Her gastrostomy tube was removed. Repeated gastrointestinal tract transit studies approached normal findings. Repeated autonomic testing and thermoregulatory sweat testing showed improvement. Over several months, the intravenous immunoglobulin dose was tapered. The patient remained asymptomatic for 8 years on long-term immunosuppression with azathioprine, she had a recurrence of her previous symptoms. Repeated gastrointestinal tract transit studies again showed delayed gastrointestinal tract emptying. Another intravenous immunoglobulin course controlled her symptoms, with normalization of gastrointestinal tract transit studies. Autoimmune gastrointestinal dysmotility can manifest as either hypomotility or hypermotility but most often presents as gastroparesis or pseudo-obstruction. Symptoms include nausea, vomiting, bloating, early satiety, diarrhea, constipation, and involuntary weight loss. It can be idiopathic or paraneoplastic. Risk factors for idiopathic cases include personal or family histories of autoimmunity.
9

Chakrabarti, Atis, Jukka Kervinen, Egbert Müller, Toru Tanaka e Kazuaki Muranaka. "Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique". In Monoclonal Antibodies [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95356.

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Most clinically approved large biotherapeutics are monoclonal antibodies (mAbs), primarily belonging to immunoglobulin G subclass-1 (IgG1) and, to a lesser extent, IgG2 and IgG4. Glycosylation is the main source of post-translational heterogeneity of mAbs, impacting their drug therapeutic mechanism of action (MOA). Glycosylation is also one of the critical factors in drug product solubility, kinetics, stability and efficacy. Thus, monitoring glycan critical quality attributes (CQAs) is an essential part of any biopharmaceutical development. The binding affinity of an IgG to its cellular Fc receptor (FcR) depends on both its IgG subclass and Fc domain glycosylation pattern. Since composition of the N-glycans also correlates to the Antibody-Dependent Cellular Cytotoxicity (ADCC), the glycosylation pattern needs to be monitored for consistency in potency and efficacy. This applies for the original mAb biologics as well as biosimilars. In this chapter, we present a truly novel way to assess the variances in mAb glycoforms using FcγRIIIa-based affinity chromatography. First, a brief overview of the Fc receptor function is presented. Then, the principle of FcR-based affinity chromatography is explained including how this column’s potential to analyze a variety of mAbs according to their N-glycan content is highly selective and robust. Finally, we provide examples of the FcR column’s potential to improve analytical characterization of mAbs with practical applications such as effective cell line screening, monitoring of glycoengineering, process development and process control in manufacturing.
10

Chakrabarti, Atis, Jukka Kervinen, Egbert Müller, Toru Tanaka e Kazuaki Muranaka. "Analytical Characterization of Monoclonal Antibodies with Novel Fc Receptor-Based Chromatography Technique". In Monoclonal Antibodies [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95356.

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Most clinically approved large biotherapeutics are monoclonal antibodies (mAbs), primarily belonging to immunoglobulin G subclass-1 (IgG1) and, to a lesser extent, IgG2 and IgG4. Glycosylation is the main source of post-translational heterogeneity of mAbs, impacting their drug therapeutic mechanism of action (MOA). Glycosylation is also one of the critical factors in drug product solubility, kinetics, stability and efficacy. Thus, monitoring glycan critical quality attributes (CQAs) is an essential part of any biopharmaceutical development. The binding affinity of an IgG to its cellular Fc receptor (FcR) depends on both its IgG subclass and Fc domain glycosylation pattern. Since composition of the N-glycans also correlates to the Antibody-Dependent Cellular Cytotoxicity (ADCC), the glycosylation pattern needs to be monitored for consistency in potency and efficacy. This applies for the original mAb biologics as well as biosimilars. In this chapter, we present a truly novel way to assess the variances in mAb glycoforms using FcγRIIIa-based affinity chromatography. First, a brief overview of the Fc receptor function is presented. Then, the principle of FcR-based affinity chromatography is explained including how this column’s potential to analyze a variety of mAbs according to their N-glycan content is highly selective and robust. Finally, we provide examples of the FcR column’s potential to improve analytical characterization of mAbs with practical applications such as effective cell line screening, monitoring of glycoengineering, process development and process control in manufacturing.

Trabalhos de conferências sobre o assunto "Recepteur immunoglobuline g":

1

Krasnoshtanova, Alla, e Alesya Yudina. "PRODUCTION OF ANTIBODIES FROM POULTRY YOLK (IgY) AND INVESTIGATION OF THEIR IMMUNOCHEMICAL PROPERTIES". In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/17.

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"A particularly important aspect of immunology is to develop non-invasive methods of obtaining antibodies which could be a great alternative to traditional ones that based on the harmful procedure of isolation of immunoglobulins from animal blood sera. That’s why the extraction of antibodies from poultry egg yolks (IgY) is the most promising. Due to the fact of variation of IgY structural features that determine the definite immunochemical properties, yolk antibodies in comparison with mammalian immunoglobulins (IgG) does not interact with rheumatoid factor (Rf), contribute to the activation of the complement system, bind to the Fc-receptor (FcR), and also has weak cross-reactivity, which confirms the possibility of their widespread use in medicine and food. Also the presence of phylogenetic distance between chickens and mammalians guarantees immune response against conservative mammalian protein molecules which is highly important for the creation of new generation test systems. The aim of this work is to develop a selective method of producing high-purity immunoglobulin Y preparations from the yolk of chicken eggs. There were adopted selective conditions of isolation of IgY under spontaneous thawing procedure at the room temperature of firstly frozen yolk solution in a sodium-phosphate buffer mixed with water (pH 5.0) in a ratio of 1:6, which leads to receiving a water-soluble fraction further precipitated with the sodium chloride at a concentration of 10% of the solution mass and subsequently concentrated using ultrafiltration with membrane UAM-10, that allows achieving the content of IgY not less than 95% per dry substance in immunoglobulin fraction. It is possible to produce a protein fraction with a protein content of at least 9 g/l. The purity of the immunoglobulin fraction was verified using polyacrylamide gel electrophoresis. The presence of a light chain in the IgY solution was proved to be a low-molecular compound using the method of gel-filtration-chromatography. The immunological activity of IgY was studied with respect to bovine serum albumin (BSA) as an antigen. The enzymatic resistance of IgY against proteolytic enzymes was tested in area of the gastrointestinal tract."
2

Brun, JG, TM Madland e CA Vedeler. "THU0170 Immunoglobulin g fc-receptor (fcgr) iiia polymorphisms and disease expression in rheumatoid arthritis". In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.1072.

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3

Zhu, Cheng, e Scott E. Chesla. "Dissociation of Individual Molecular Bonds Under Force". In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0286.

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Abstract Specific interactions between receptors on cell surfaces are essential for living organisms to sense and adapt to their environment. For example, CD16A (Feγ receptor IIIA) signals a variety of immune functions upon binding of immunoglobulin (Ig) G. While receptor-ligand binding has been extensively studied in chemical terms, only until very recently has direct measurement of individual bond forces become possible. Evans et al. [1] pioneered the use of the micropipet technique to measure detachment forces between two red blood cells (RBC) crosslinked by antibodies. While these authors achieved the sensitivity necessary to detect individual bonds (in piconewton range), the forces they measured appeared to be those of uprooting the molecules from the cell membrane (cohesive detachment mode) instead of dissociating the antibody-antigen bonds (adhesive detachment mode).
4

Shimizu, C., K. Tamura, F. Koizumi, K. Aogi, T. Kinoshita e Y. Fujiwara. "Immunoglobulin G fragment C gamma receptor (FcGR) polymorphisms and efficacy of single-agent trastuzumab in patients treated with metastatic breast cancer." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-6073.

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Musolino, Antonino, Valentina Guarneri, Nadia Naldi, Beatrice Bortesi, Daniela Boggiani, Paolo Sgargi, Daniele G. Generali et al. "Abstract P3-06-23: Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of preoperative chemotherapy plus trastuzumab and lapatinib in patients with HER2-positive operable breast cancer". In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p3-06-23.

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