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Bibliografias temáticas / RNA viruses

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Literatura científica selecionada sobre o tema "RNA viruses"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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Artigos de revistas sobre o assunto "RNA viruses"

1

Shi, Rui-Zhu, Yuan-Qing Pan, and Li Xing. "RNA Helicase A Regulates the Replication of RNA Viruses." Viruses 13, no. 3 (2021): 361. http://dx.doi.org/10.3390/v13030361.

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The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication. Herein, this review will provide an overview of the role of RHA in the replication of RNA viruses.

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Ahlquist, Paul. "Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses." Nature Reviews Microbiology 4, no. 5 (2006): 371–82. http://dx.doi.org/10.1038/nrmicro1389.

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Yang, Jie, Hongjie Xia, Qi Qian, and Xi Zhou. "RNA chaperones encoded by RNA viruses." Virologica Sinica 30, no. 6 (2015): 401–9. http://dx.doi.org/10.1007/s12250-015-3676-2.

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Sokoloski, Kevin J., Carol J. Wilusz, and Jeffrey Wilusz. "Viruses: Overturning RNA Turnover." RNA Biology 3, no. 4 (2006): 140–44. http://dx.doi.org/10.4161/rna.3.4.4076.

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Enami, Masayoshi. "Negative-strand RNA viruses. Reverse genetics of negative-strand RNA viruses." Uirusu 45, no. 2 (1995): 145–57. http://dx.doi.org/10.2222/jsv.45.145.

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Ahlquist, P. "RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing." Science 296, no. 5571 (2002): 1270–73. http://dx.doi.org/10.1126/science.1069132.

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Newburn, Laura R., and K. Andrew White. "Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses." Viruses 11, no. 8 (2019): 751. http://dx.doi.org/10.3390/v11080751.

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RNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in different forms, including double-stranded RNA, coding-sense single-stranded RNA, and noncoding single-stranded RNA. Genera that possess these genome types include, respectively, Orbivirus (e.g., Bluetongue virus), Dianthovirus (e.g., Red clover necrotic mosaic virus) and Alphainfluenzavirus (e.g., Inf

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SATO, Hironori, and Masaru YOKOYAMA. "RNA viruses and mutations." Uirusu 55, no. 2 (2005): 221–29. http://dx.doi.org/10.2222/jsv.55.221.

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MINE, Akira, and Tetsuro OKUNO. "Viruses and RNA silencing." Uirusu 58, no. 1 (2008): 61–68. http://dx.doi.org/10.2222/jsv.58.61.

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Strauss, J. H., and E. G. Strauss. "Evolution of RNA Viruses." Annual Review of Microbiology 42, no. 1 (1988): 657–83. http://dx.doi.org/10.1146/annurev.mi.42.100188.003301.

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Teses / dissertações sobre o assunto "RNA viruses"

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Chare, Elizabeth R. "Recombination in RNA viruses and plant virus evolution." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433381.

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Olabode, Abayomi. "The evolution of RNA viruses." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-evolution-of-rna-viruses(ac87e71c-e9ce-44c6-8dc1-6adbb01e5efb).html.

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This thesis analyzes the evolutionary trajectories that drive the evolution of several RNA viruses. These viruses have been identified to be the leading causes of viral outbreaks and deaths in humans. Studying the mechanisms influencing their evolution could therefore produce vital information for controlling the spread of these viruses or for their eradication. The availability of huge sequence repositories and advancement in computing and sequencing technologies allows for the development of novel methods for understanding the evolution of viruses even during an on-going outbreak, epidemic o

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Choudhury, Md Abu Hasnat Zamil. "Population Dynamics of RNA viruses." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/60866/1/Md._Choudhury_Thesis.pdf.

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Between 50 and 100 million people are infected with dengue viruses each year and more than 100,000 of these die. Dr Choudhury has demonstrated that populations of dengue viruses in individual patients are genetically and functionally very diverse and that this diversity changes significantly at the time of major outbreaks of disease. The results of his studies may inform strategies which will make dengue vaccines far more effective.

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Bakker, Saskia. "RNA packaging and uncoating in simple single-stranded RNA viruses." Thesis, University of Leeds, 2012. http://etheses.whiterose.ac.uk/2801/.

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Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron microscopy (cryo-EM) are shown for the native and the expanded form. The expanded form is a putative disassembly intermediate and exhibits pores that are large enough to allow exit of single-stranded RNA. Biochemical experiments revealed the expanded form is protease-sensitive, although the RNA genome remains protected from ribonuclease. Virus

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Wain, Louise V. "Origins of diversity of RNA viruses." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440123.

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Willcocks, Margaret Mary. "Small RNA viruses associated with diarrhoea." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287271.

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Boz, Mustafa Burak. "Modeling and simulations of single stranded rna viruses." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44815.

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The presented work is the application of recent methodologies on modeling and simulation of single stranded RNA viruses. We first present the methods of modeling RNA molecules using the coarse-grained modeling package, YUP. Coarse-grained models simplify complex structures such as viruses and let us study general behavior of the complex biological systems that otherwise cannot be studied with all-atom details. Second, we modeled the first all-atom T=3, icosahedral, single stranded RNA virus, Pariacoto virus (PaV). The x-ray structure of PaV shows only 35% of the total RNA genome and 8

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Li, Tin-wai Olive. "Influenza polymerase subunit compatibility between human H1 and H5 viruses." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41896890.

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Keese, Paul Konrad. "Structures of viroids and virusoids and their functional significance." Title page, contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phk268.pdf.

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Afsharifar, Alireza. "Characterisation of minor RNAs associated with plants infected with cucumber mosaic virus." Title page, table of contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09pha2584.pdf.

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Bibliography: leaves 127-138. This thesis studies the minor double stranded RNAs (dsRNA) and single stranded RNAs (ssRNA) which are consistently associated with plants infected with Q strain of cucumber mosaic virus (Q-CMV). The investigations are focused on the structural elucidation of new RNAs which have been observed in single stranded and double stranded RNA profiles of Q strain of CMV.

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Mais fontes

Livros sobre o assunto "RNA viruses"

1

A, Brinton Margo, Calisher Charles H, Rueckert Roland R, and International Symposium on Positive Strand RNA Viruses (3rd : 1992 : Clearwater, Fla.), eds. Positive-strand RNA viruses. Springer-Verlag, 1994.

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Luo, Ming. Negative strand RNA virus. World Scientific, 2011.

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A, Brinton Margo, and Heinz Franz X, eds. New aspects of positive-strand RNA viruses. American Society for Microbiology, 1990.

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Brinton, Margo A., Charles H. Calisher, and Roland Rueckert, eds. Positive-Strand RNA Viruses. Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9326-6.

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F, Murant A., and Harrison B. D, eds. The plant viruses. Plenum Press, 1996.

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D, Harrison B., and Murant A. F, eds. Poly hedral virions and bipartite RNA genomes. Plenum Press, 1996.

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Luo, Ming. Negative strand RNA virus. World Scientific, 2011.

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Holmes, Edward C. The evolution and emergence of RNA viruses. Oxford University Press, 2009.

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Holland, John J., ed. Genetic Diversity of RNA Viruses. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77011-1.

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Perez, Daniel R., ed. Reverse Genetics of RNA Viruses. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6964-7.

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Capítulos de livros sobre o assunto "RNA viruses"

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Fusaki, Noemi. "Nonintegrating RNA Viruses." In Primary and Stem Cells. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118147177.ch6.

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Hodinka, Richard L. "Respiratory RNA Viruses." In Diagnostic Microbiology of the Immunocompromised Host. ASM Press, 2016. http://dx.doi.org/10.1128/9781555819040.ch11.

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Ball, Jonathan. "Analysis of RNA virus quasispecies." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0006.

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Abstract A virus quasispecies can be thought of as a complex population of genetically related yet distinct variants (1). The term has been used to describe populations of a number of RNA viruses, e.g. human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Although this definition of a quasispecies appears simple in theory, in practice it can be rather ambiguous (2). For example, the term has been applied to describe unrelated viruses present in different individuals, unrelated viruses arising from multiple infections within the same individual, and to genetically related but

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Bridgen, A., and R. M. Elliott. "Reverse genetics of RNA viruses." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0009.

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Abstract RNA viruses comprise many of the most serious human pathogens. There are now possibly 500 million carriers of hepatitis C virus world-wide (1). Rotavirus infections are responsible for around 18 million cases of severe diarrhoea and nearly 1 million deaths in young children in developing countries annually (2). Measles is still also one of the leading causes of infant death in developing countries, and can induce the rare, but fatal, neurodegenerative disease subacute sclerosing panencephalitis (3). Many human respiratoiy infections are caused by RNA viruses such as influenza, human r

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Makino, S. "Analysis of transcriptional control in RNA virus infection." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0003.

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Abstract This chapter will illustrate several commonly used methods for the analysis of mRNAs and their transcriptional control by RNA viruses. I will first describe the conventional methods for characterizing mRNAs in virus-infected cells. Subsequently, methods utilizing genetically engineered virus RNA or cDNA with or without reporter genes will be described. These methods enable the analysis of cis- and trans-acting RNA sequences to be determined.

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Barclay, Wendy S., and Jeffrey W. Almond. "Mutagenesis of RNA virus genomes." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0002.

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Abstract Since the pioneering experiments of Burnett (1) and Cooper (2) in the 1950s and 1960s, the isolation of RNA virus mutants has been a cornerstone of studies aimed at determining the function of virus genomes and their encoded proteins. Not only have the phenotypes of individual mutants been informative about the replication and biology of the wild-type virus, but, collectively, the exploitation of mutants in complementation and recombination assays has provided useful information on the number of genes and the sizes of genomes. Nowadays the generation of mutants is a routine procedure

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Neil, J. C., and A. Terry. "Detection and analysis of host gene targets for oncogenic retroviruses." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0005.

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Abstract Unlike the DNA viruses, where oncogenic representatives are found in disparate families, only two RNA virus families, the Retroviridae and the Flavoviridae, have so far been implicated in neoplasia. The mechanisms by which the latter operate are largely unknown and the prototypic example, hepatitis C virus, appears to be an indirect cause of cancer, for which the roles of specific gene products are as yet undetermined. In contrast, the Retroviridae have received much attention as causes of cancer. Animal retroviruses have been studied for many years, mainly as model carcinogens; their

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Banerjee, R., M. go, R. Izumi, U. Datta, and A. Dasgupta. "In vitro replication of RNA viruses." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0007.

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Abstract RNA viruses are very diverse and utilize many distinct strategies for replicating their genomes. The genome organization of these viruses vary widely, thus the translation and replication strategies employed must also be varied. However, despite all the complexities of RNA viruses and their differing replication strategies, there are many similarities at the molecular level (1). Some of the common in vitro techniques employed to study these RNA replication strategies as well as methodologies to study in vitro RNA-protein interactions will be discussed in this chapter.

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Barr, J., and J. W. McCauley. "Packaging of segmented and non-segmented RNA virus genomes." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0008.

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Abstract The process of virus assembly describes the events by which the mature virion is formed from its constituent components within an infected cell. Because viruses come in such a wide variety of structural arrangements and consequently have adopted incredibly diverse assembly strategies, this definition is by necessity very broad. The range of processes included in this term ‘assembly’ are extremely varied and range from simple associations of a genome with no more than a few types of protein (Tobacco Mosaic Virus, TMV, or X174) to the formation of a virion comparable in size to a small

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Easton, A. J., AC Marriott, and C. R. Pringle. "Investigation of RNA virus genome structure." In RNA Viruses. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637171.003.0001.

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Abstract RNA Viruses: A Practical Approach is wide ranging in scope, from emerging technology such as reverse genetics and retrovirus vectors, to money saving tips - how to make your own silica particles for high efficiency RNA extraction and liposomes for cell transfection.

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Trabalhos de conferências sobre o assunto "RNA viruses"

1

Belov, George. "COUPLING POLIOVIRUS RNA REPLICATION TO CELLULAR MEMBRANES." In Viruses: Discovering Big in Small. TORUS PRESS, 2019. http://dx.doi.org/10.30826/viruses-2019-12.

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Aleshina, Yu A., A. V. Orlov, and A. N. Lukashev. "RECOMBINATION AND MODULAR EVOLUTION OF POSITIVE-STRAND RNA VIRUSES." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-227.

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Recombination is one of the major forces generating genetic diversity in positive-strand RNA viruses. We systematically analyzed patterns of natural recombination in four (+)RNA virus families — Astroviridae, Caliciviridae, Picornaviridae and Coronaviridae, using both classical recombination detection methods and by comparing correspondence of genetic distances in different genome regions.

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Evseev, Peter, Sergey Potapov, Galina Podlesnaya, Andrei Krasnopeev, Anna Gorshkova, and Olga Belykh. "Horizontal Gene Transfer Involving RNA Viruses and DNA Viruses." In 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB). IEEE, 2022. http://dx.doi.org/10.1109/csgb56354.2022.9865651.

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Alipanah, Morteza, Carlos Manzanas, John A. Lednicky, Chang-Yu Wu, and Z. Hugh Fan. "Integration of Minivalves With RNA Amplification Device for Simultaneous Detection of SARS-CoV-2 and Influenza Viruses." In ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-96831.

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Abstract We report a point-of-care (POC) device for simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A viruses. The device carries out sample preparation using ball-based valves for sequential delivery of reagents. A microfluidic paper-based analytical device (μPAD) in the detection unit enables RNA isolation and enrichment, followed by reverse transcription loop-mediated isothermal amplification (RT-LAMP) and colorimetric detection. The device integrates all the necessary steps for the sample preparation, including virus lysis, RNA enrichmen

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Alipanah, Morteza, John A. Lednicky, J. Glenn Morris, and Z. Hugh Fan. "A Point-Of-Care Device Integrating Sample Preparation With Isothermal Amplification for Detection of Mayaro Virus." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-114292.

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Abstract Mayaro virus (MAYV) is an emerging mosquito-borne alphavirus that causes clinical symptoms similar to those caused by Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). To differentiate MAYV from these viruses diagnostically, we have developed the first reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for detection of MAYV. We designed six LAMP primers targeting MAYV’s non-structural protein (NS1) gene and determined the visual limit of detection of at least 10 viral genome equivalents (GEs) per reaction. The assay was specific for MAYV,

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Karelina, K. V., R. B. Bayandin, S. E. Pashkovsky, and V. A. Ternovoi. "DETECTION OF GENETIC MARKERS OF FLAVI-LIKE VIRUSES IN SAMPLES OF TICKS IXODES PERSULCATUS AND IXODES PAVLOVSKYI COLLECTED IN THE NOVOSIBIRSK REGION." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-189.

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) belonging to the family Flaviviridae, which are transmitted by ticks. Recently, there are emerging data on the detection of novel tick-borne Flaviviridae-like viruses in febrile patients. We screened ticks collected in the Novosibirsk region to detect segmented flavi-like viruses in the Novosibirsk region. 235 ticks of Ixodes persulcatus and Ixodes pavlovkyi species (47 pools) were taken into the study; PCR method revealed 7 positive samples for Jingmen tick virus RNA, the infection rate amounted to 14.8 ± 2 %.

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Sivov, I. G., and I. S. Firsov. "FLECK QUANTIFICATION OF THE NUMBER OF INFECTIOUS SARS-COV-2 CORONAVIRUS PARTICLES." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-173.

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The principle of obtaining sensors for detecting infectious particles of RNA viruses in samples was proposed for the diagnosis of infectious particles SARS-CoV-2. Previously, the similar sensor pattern was successfully applied in relation to the hepatitis C virus. It was founded that the ratio of the RNA titer, determined in the RT-PCR reaction in Real Time mode, refers to the number of infectious («shine») centers formed on the cell sensor culture, approximately as 100: 1, in the «coronavirus-positive» sample.

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Benslimane, Fatiha M., Hebah Al Khatib, Dana Albatesh, et al. "Nanopore Sequencing SARS-CoV-2 Genome in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0289.

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Background: The current pandemic, COVID-19, is cause by an RNA Coronavirus that was recently identified as SARS-CoV-2. RNA viruses tend to have a high mutation rate; the rate is around a million times greater than that of their hosts. The mutagenic potential of the virus depends on many factors, including the fidelity of nucleic acid-replicating viral enzymes, such as SARSCoV-2 RNA dependent RNA polymerase (RdRp). The rate of mutation drives viral evolution and genome variability, consequently allowing viruses to escape the immunity of the host and develop resistance to drugs. Therefore, the c

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Okhezin, E. V., A. G. Litov, and G. G. Karganova. "RESISTANCE OF VIRAL RNA STRUCTURES OF FLAVI-LIKE VIRUSES WITH SEGMENTED GENOME TO XRN1 EXONUCLEASE." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-258.

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Subgenomic orthoflaviviral RNA is a product of incomplete degradation of genomic orthoflavivirus RNA by 5’-3’ cell exoribonuclease XRN1. Resistance to complete hydrolysis is determined by conserved secondary structure motifs localized at the 3’ end of the genomic RNA. In this research, we study the exonuclease resistance of genomic RNA segments Alonghan virus in an in vitro assay

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Mintaev, R. R., D. V. Glazkova, O. V. Orlova, F. A. Urusov, G. A. Shipulin, and E. V. Bogoslovskaya. "DEVELOPMENT OF THE TECHNOLOGY PLATFORM BASED ON THE MODIFIED VACCINIA ANKARA FOR RAPID PRODUCTION OF VECTOR VACCINES." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-194.

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Infectious diseases, including viral diseases, are a major cause of death and disability. Vaccination is the most effective means of protection, but the efficacy and safety of vaccines are often unsatisfactory. The aim of this study is to develop methods for the rapid production of immunogenic MVA-based vector vaccines against RNA viruses. We created candidate vaccines against influenza virus and against dengue virus based on MVA vector.

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Relatórios de organizações sobre o assunto "RNA viruses"

1

Davison, Michelle, Ruonan Wu, Vincent Danna, and Iobani Godinez. Uncovering novel RNA viruses in permafrost. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1776877.

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2

Morris, T. J., and A. O. Jackson. Characterization of defective interfering RNAs associated with RNA plant viruses. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/6880107.

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3

Gal-On, Amit, Shou-Wei Ding, Victor P. Gaba, and Harry S. Paris. role of RNA-dependent RNA polymerase 1 in plant virus defense. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597919.bard.

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Objectives: Our BARD proposal on the impact of RNA-dependent RNA polymerase 1 (RDR1) in plant defense against viruses was divided into four original objectives. 1. To examine whether a high level of dsRNA expression can stimulate RDR1 transcription independent of salicylic acid (SA) concentration. 2. To determine whether the high or low level of RDR1 transcript accumulation observed in virus resistant and susceptible cultivars is associated with viral resistance and susceptibility. 3. To define the biogenesis and function of RDR1-dependent endogenous siRNAs. 4. To understand why Cucumber mosai

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4

Mawassi, Munir, and Valerian Dolja. Role of RNA Silencing Suppression in the Pathogenicity and Host Specificity of the Grapevine Virus A. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592114.bard.

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RNA silencing is a defense mechanism that functions against virus infection and involves sequence-specific degradation of viral RNA. Diverse RNA and DNA viruses of plants encode RNA silencing suppressors (RSSs), which, in addition to their role in viral counterdefense, were implicated in the efficient accumulation of viral RNAs, virus transport, pathogenesis, and determination of the virus host range. Despite rapidly growing understanding of the mechanisms of RNA silencing suppression, systematic analysis of the roles played by diverse RSSs in virus biology and pathology is yet to be completed

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5

Morris, T. J., and A. O. Jackson. Characterization of defective interfering RNAs associated with RNA plant viruses. Progress report. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10139870.

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6

Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r

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7

Sette, Alesandro, Bjoern Peters, and Martin Blythe. Predicting the Interplay of Epitope Recognition and Evolution in RNA Viruses Under Immune Pressure. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada500852.

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8

ARIZONA STATE UNIV TEMPE CANCER RESEARCH INST. Discovery and Development of Therapeutic Drugs Against Lethal Human RNA Viruses: A Multidisciplinary Assault. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada251561.

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9

Pettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA Viruses: a Multidisciplinary Assault. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada239742.

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10

Pettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA- Viruses: A Multidisciplinary Assault. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada219393.

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