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Artigos de revistas sobre o tema "Screening natural products"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Harvey, Alan L. "Natural products as a screening resource." Current Opinion in Chemical Biology 11, no. 5 (2007): 480–84. http://dx.doi.org/10.1016/j.cbpa.2007.08.012.

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Overacker, RD, and S. Loesgen. "Antiviral screening of microbial natural products." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596288.

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de Sousa Luis, José Alixandre. "Virtual Screening of Natural Products Database." Mini-Reviews in Medicinal Chemistry 21, no. 18 (2021): 2657–730. http://dx.doi.org/10.2174/18755607mta49nzeu3.

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4

Lahlou, Mouhssen. "Screening of natural products for drug discovery." Expert Opinion on Drug Discovery 2, no. 5 (2007): 697–705. http://dx.doi.org/10.1517/17460441.2.5.697.

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Silver, L., and K. Bostian. "Screening of natural products for antimicrobial agents." European Journal of Clinical Microbiology & Infectious Diseases 9, no. 7 (1990): 455–61. http://dx.doi.org/10.1007/bf01964283.

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Arvidson, Kirk B., Luis G. Valerio, Marilyn Diaz, and Ronald F. Chanderbhan. "In Silico Toxicological Screening of Natural Products." Toxicology Mechanisms and Methods 18, no. 2-3 (2008): 229–42. http://dx.doi.org/10.1080/15376510701856991.

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Nishad, V. M* Anu S. A. S. William Arputha Sundar. "A REVIEW ON NATURAL PRODUCTS IN DRUG DISCOVERY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11556–63. https://doi.org/10.5281/zenodo.1479238.

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<em>Drug discovery from medicinal plants has evolved to include numerous fields of inquiry and various methods of analysis. The process typically begins with a botanist, ethnobotanist, ethnopharmacologist, or plant ecologist who collects and identifies the plant(s) of interest. Collection may involve species with known biological activity for which active compound(s) have not been isolated (e.g., traditionally used herbal remedies) or may involve taxa collected randomly for a large screening program. It is necessary to respect the intellectual property rights of a given country where plant(s)

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YAMAHARA, JOHJI, SHUJI MIKI, HISASHI MATSUDA, and HAJIME FUJIMURA. "Screening Test for Calcium Antagonists in Natural Products." YAKUGAKU ZASSHI 106, no. 10 (1986): 888–93. http://dx.doi.org/10.1248/yakushi1947.106.10_888.

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George G. Harrigan and Gilles H. Goetz. "Chemical and Biological Integrity in Natural Products Screening." Combinatorial Chemistry & High Throughput Screening 8, no. 6 (2005): 529–34. http://dx.doi.org/10.2174/1386207054867292.

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Khan, N. N., and Linda L. Nolan. "SCREENING OF NATURAL PRODUCTS FOR ANTILEISHMANIAL CHEMOTHERAPEUTIC POTENTIAL." Acta Horticulturae, no. 426 (August 1996): 47–56. http://dx.doi.org/10.17660/actahortic.1996.426.4.

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Calcul, Laurent, Carrie Waterman, Wai Ma, et al. "Screening Mangrove Endophytic Fungi for Antimalarial Natural Products." Marine Drugs 11, no. 12 (2013): 5036–50. http://dx.doi.org/10.3390/md11125036.

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Reynolds, T. "Stat Bite NCI'S Natural Products Aequisition and Screening." JNCI Journal of the National Cancer Institute 85, no. 17 (1993): 1367–68. http://dx.doi.org/10.1093/jnci/85.17.1367.

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Futamura, Yushi, Kai Yamamoto, and Hiroyuki Osada. "Phenotypic screening meets natural products in drug discovery." Bioscience, Biotechnology, and Biochemistry 81, no. 1 (2016): 28–31. http://dx.doi.org/10.1080/09168451.2016.1248365.

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14

Singh, Sheo B., Katherine Young, and Lynn Miesel. "Screening strategies for discovery of antibacterial natural products." Expert Review of Anti-infective Therapy 9, no. 8 (2011): 589–613. http://dx.doi.org/10.1586/eri.11.81.

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15

Tian, Wen-Jun, and Xiao-Jia Wang. "Broad-Spectrum Antivirals Derived from Natural Products." Viruses 15, no. 5 (2023): 1100. http://dx.doi.org/10.3390/v15051100.

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Scientific advances have led to the development and production of numerous vaccines and antiviral drugs, but viruses, including re-emerging and emerging viruses, such as SARS-CoV-2, remain a major threat to human health. Many antiviral agents are rarely used in clinical treatment, however, because of their inefficacy and resistance. The toxicity of natural products may be lower, and some natural products have multiple targets, which means less resistance. Therefore, natural products may be an effective means to solve virus infection in the future. New techniques and ideas are currently being d

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16

Yang, Baoyu, Jing Mao, Bing Gao, and Xiuli Lu. "Computer-Assisted Drug Virtual Screening Based on the Natural Product Databases." Current Pharmaceutical Biotechnology 20, no. 4 (2019): 293–301. http://dx.doi.org/10.2174/1389201020666190328115411.

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Background:Computer-assisted drug virtual screening models the process of drug screening through computer simulation technology, by docking small molecules in some of the databases to a certain protein target. There are many kinds of small molecules databases available for drug screening, including natural product databases.Methods:Plants have been used as a source of medication for millennia. About 80% of drugs were either natural products or related analogues by 1990, and many natural products are biologically active and have favorable absorption, distribution, metabolization, excretion, and

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Zaghlool Al-Khayyat, Mohammed. "In silico screening of natural products targeting chorismate synthase." Innovaciencia Facultad de Ciencias Exactas Físicas y Naturales 7, no. 1 (2019): 1–9. http://dx.doi.org/10.15649/2346075x.505.

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Introduction: Chorismate synthase catalyzes the final step in shikimate acid pathway involved in synthesis of aromatic compounds in bacteria.This enzyme can be a possible molecular target for design of antibiotics. Materials and Methods: Homology modeling and molecular dockingwere performed to screen about one hundred natural compounds in order to find inhibitors of enzymes as a possible new target. A model wasbuilt by SWISS-MODEL and its quality was assessed by ERRAT, ProSA, Rampage and MolProbity servers. Docking experiments were performedand pharmacokinetics and toxicities were studied by a

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Caballero-George, Catherina. "Natural Products Research in Latin America: Beyond the Screening." Combinatorial Chemistry & High Throughput Screening 25, no. 7 (2022): 1127–28. http://dx.doi.org/10.2174/138620732507220406100501.

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Valgas, Cleidson, Simone Machado de Souza, Elza F. A. Smânia, and Artur Smânia Jr. "Screening methods to determine antibacterial activity of natural products." Brazilian Journal of Microbiology 38, no. 2 (2007): 369–80. http://dx.doi.org/10.1590/s1517-83822007000200034.

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Kuchuk, Nikolay V., Valeria B. Belokurova, Nadia A. Matvieieva, et al. "Screening Plant Biodiversity In Vitro for New Natural Products." Industrial Biotechnology 10, no. 5 (2014): 363–68. http://dx.doi.org/10.1089/ind.2014.0015.

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SHIONO, Yoshihito, and Ken-ichi KIMURA. "Screening for Biologically Active Natural Products from Endophytic Fungi." KAGAKU TO SEIBUTSU 47, no. 6 (2009): 390–96. http://dx.doi.org/10.1271/kagakutoseibutsu.47.390.

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Harvey, Alan, and Ian Cree. "High-Throughput Screening of Natural Products for Cancer Therapy." Planta Medica 76, no. 11 (2010): 1080–86. http://dx.doi.org/10.1055/s-0030-1250162.

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Ishibashi, Masami. "Screening for natural products that affect Wnt signaling activity." Journal of Natural Medicines 73, no. 4 (2019): 697–705. http://dx.doi.org/10.1007/s11418-019-01320-9.

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Schmeda-Hirschmann, Guillermo, and Antonieta Rojas de Arias. "A screening method for natural products on triatomine bugs." Phytotherapy Research 6, no. 2 (1992): 68–73. http://dx.doi.org/10.1002/ptr.2650060204.

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25

Anand, Kumar, Sayak Khawas, Apurva Singh, Puja kumari, Neha Nupur, and Neelima Sharma. "Harnessing the Power of Natural Products in Drug Discovery." Journal of Pharmaceutical Technology, Research and Management 11, no. 1 (2023): 1–18. http://dx.doi.org/10.15415/jptrm.2023.111001.

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Background: Natural products and their structural analogues have historically played a crucial role in pharmacotherapy, especially in the treatment of cancer and infectious diseases. However, various challenges including screening, isolation, characterization and effectiveness contributed to a decline in natural product research within the pharmaceutical industry. Purpose: This review explores the enduring use of natural compounds in folk medicine with special focus on drug discovery inspired by multifaceted molecular roles of small molecules from natural sources. The article also aims to eluc

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Ashwag Ahmed Abdel rahman Mohamed Nour. "Anti-tumor response of some natural products." GSC Advanced Research and Reviews 17, no. 2 (2023): 162–66. http://dx.doi.org/10.30574/gscarr.2023.17.2.0423.

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The role of natural products as asource for remedies has been recognized since ancient times. Many pharmaceutical agents have been discovered by screening natural products. This study will briefly summarize research on the study of antitumor effects of some plant natural products (Bee honey, Cumin extract, a combination of both at a rate of 1:1, Ginger extracts and Tepary beans Lectin). The crudes extract obtained by cold extraction were evaluated for antibacterial by using disc diffusion method and antitumor activity by using Agrobacterium tumefaciensstrain SDB0012 (local isolate ) as biologi

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27

Yuan, Yutong, Fei Pan, Zehui Zhu, et al. "Construction of a QSAR Model Based on Flavonoids and Screening of Natural Pancreatic Lipase Inhibitors." Nutrients 15, no. 15 (2023): 3489. http://dx.doi.org/10.3390/nu15153489.

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Pancreatic lipase (PL) is a key hydrolase in lipid metabolism. Inhibition of PL activity can intervene in obesity, a global sub-health disease. The natural product is considered a good alternative to chemically synthesized drugs due to its advantages, such as low side effects. However, traditional experimental screening methods are labor-intensive and cost-consuming, and there is an urgent need to develop high-throughput screening methods for the discovery of anti-PL natural products. In this study, a high-throughput virtual screening process for anti-PL natural products is provided. Firstly,

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28

Grabowski, Kristina, Ewgenij Proschak, Karl-Heinz Baringhaus, Oliver Rau, Manfred Schubert-Zsilavecz, and Gisbert Schneider. "Bioisosteric Replacement of Molecular Scaffolds: From Natural Products to Synthetic Compounds." Natural Product Communications 3, no. 8 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300821.

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Natural products often contain scaffolds or core structures that prevent immediate synthetic accessibility. It is, therefore, desirable to find isosteric chemotypes that allow for scaffold-hopping or re-scaffolding. The idea is to obtain simpler chemotypes that are synthetically feasible and exhibit either the same or similar bioactivity as the original natural product or reference compound. We developed and applied a virtual screening technique that represents a molecular scaffold by its side-chain attachment points (exit-vectors) and properties of the side-chain substituents. The technique w

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Ashwag, Ahmed Abdel rahman Mohamed Nour. "Anti-tumor response of some natural products." GSC Advanced Research and Reviews 17, no. 2 (2023): 162–66. https://doi.org/10.5281/zenodo.10615113.

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The role of natural products as asource for remedies has been recognized since ancient times. Many pharmaceutical agents have been discovered by screening natural products. This study will briefly summarize research on the study of antitumor effects of some plant natural products (Bee honey, Cumin extract, a combination of both at a rate of 1:1, Ginger extracts and Tepary beans Lectin). The crudes extract obtained by cold extraction were evaluated for antibacterial by using disc diffusion method and antitumor activity by using <em>Agrobacterium tumefaciens</em>strain SDB0012 (local isolat

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30

Wang, Ming-Wei, Xiaojiang Hao, and Kaixian Chen. "Biological screening of natural products and drug innovation in China." Philosophical Transactions of the Royal Society B: Biological Sciences 362, no. 1482 (2007): 1093–105. http://dx.doi.org/10.1098/rstb.2007.2036.

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Natural products have been applied to human healthcare for thousands of years. Drug discovery in ancient times was largely by chance and based on clinical practices. As understanding of therapeutic benefits deepens and demands for natural products increase, previously serendipitous discoveries evolve into active searches for new medicines. Many drugs presently prescribed by physicians are either directly isolated from plants or are artificially modified versions of natural products. Scientists are looking for lead compounds with specific structures and pharmacological effects often from natura

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Xu, Tingjun, Weiming Chen, Junhong Zhou, Jingfang Dai, Yingyong Li, and Yingli Zhao. "Virtual Screening for Reactive Natural Products and Their Probable Artifacts of Solvolysis and Oxidation." Biomolecules 10, no. 11 (2020): 1486. http://dx.doi.org/10.3390/biom10111486.

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Chemically unstable natural products are prone to show their reactivity in the procedures of extraction, purification, or identification and turn into contaminants as so-called “artifacts”. However, identification of artifacts requires considerable investments in technical equipment, time, and human resources. For revealing these reactive natural products and their artifacts by computational approaches, we set up a virtual screening system to seek cases in a biochemical database. The screening system is based on deep learning models of predicting the two main classifications of conversion reac

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Motika, Stephen E., and Paul J. Hergenrother. "Re-engineering natural products to engage new biological targets." Natural Product Reports 37, no. 11 (2020): 1395–403. http://dx.doi.org/10.1039/d0np00059k.

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Incorporating natural product-like features within small-molecule screening collections is of great interest. We highlight an emerging strategy that achieves this goal by using abundant natural products as starting points for compound construction.

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Xin, Gui-Zhong, Jian-Liang Zhou, Lian-Wen Qi, and Ping Li. "Mass Spectrometry-Based Strategies for Screening of Bioactive Natural Products." Combinatorial Chemistry & High Throughput Screening 14, no. 2 (2011): 93–103. http://dx.doi.org/10.2174/138620711794474060.

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González-Maldonado, Pamela, Nelson Alvarenga, Alberto Burgos-Edwards, et al. "Screening of Natural Products Inhibitors of SARS-CoV-2 Entry." Molecules 27, no. 5 (2022): 1743. http://dx.doi.org/10.3390/molecules27051743.

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The COVID-19 pandemic has led to the search for new molecules with antiviral activity against SARS-CoV-2. The entry of the virus into the cell is one of the main targets for inhibiting SARS-CoV-2 infection. Natural products are an important source of new therapeutic alternatives against diseases. Pseudotyped viruses allow the study of SARS-CoV-2 viral entry inhibitors, and due to their simplicity, they allow the screening of a large number of antiviral candidates in Biosafety Level 2 facilities. We used pseudotyped HIV-1 with the D614G SARS-CoV-2 spike glycoprotein to test its ability to infec

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Blunder. "A Norepinephrine Transporter Assay for the Screening of Natural Products." Scientia Pharmaceutica 77, no. 1 (2009): 241. http://dx.doi.org/10.3797/scipharm.oephg.21.po-42.

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Zhou, Meng, Hao Luo, Zhi Li, et al. "Recent Advances in Screening of Natural Products for Antimicrobial Agents." Combinatorial Chemistry & High Throughput Screening 15, no. 4 (2012): 306–15. http://dx.doi.org/10.2174/138620712799361861.

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Noguchi, Taro, Shinya Oishi, Kaori Honda, et al. "Screening of a virtual mirror-image library of natural products." Chemical Communications 52, no. 49 (2016): 7653–56. http://dx.doi.org/10.1039/c6cc03114e.

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Chen, C., F. Q. Yang, H. L. Zuo, Y. L. Song, Z. N. Xia, and W. Xiao. "Applications of Biochromatography in the Screening of Bioactive Natural Products." Journal of Chromatographic Science 51, no. 8 (2013): 780–90. http://dx.doi.org/10.1093/chromsci/bmt002.

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Coma, Isabel, Deepak Bandyopadhyay, Emilio Diez, Emilio Alvarez Ruiz, Maria Teresa de los Frailes, and Gonzalo Colmenarejo. "Mining Natural-Products Screening Data for Target-Class Chemical Motifs." Journal of Biomolecular Screening 19, no. 5 (2014): 749–57. http://dx.doi.org/10.1177/1087057114521463.

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In this article, we describe two complementary data-mining approaches used to characterize the GlaxoSmithKline (GSK) natural-products set (NPS) based on information from the high-throughput screening (HTS) databases. Both methods rely on the aggregation and analysis of a large set of single-shot screening data for a number of biological assays, with the goal to reveal natural-product chemical motifs. One of them is an established method based on the data-driven clustering of compounds using a wide range of descriptors,1 whereas the other method partitions and hierarchically clusters the data t

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Schuster, Daniela, and Gerhard Wolber. "Identification of Bioactive Natural Products by Pharmacophore-Based Virtual Screening." Current Pharmaceutical Design 16, no. 15 (2010): 1666–81. http://dx.doi.org/10.2174/138161210791164072.

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Abitbol, Arjuna, Brody Mallard, Evelin Tiralongo, and Joe Tiralongo. "Mushroom Natural Products in Neurodegenerative Disease Drug Discovery." Cells 11, no. 23 (2022): 3938. http://dx.doi.org/10.3390/cells11233938.

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The variety of drugs available to treat neurodegenerative diseases is limited. Most of these drug’s efficacy is restricted by individual genetics and disease stages and usually do not prevent neurodegeneration acting long after irreversible damage has already occurred. Thus, drugs targeting the molecular mechanisms underlying subsequent neurodegeneration have the potential to negate symptom manifestation and subsequent neurodegeneration. Neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple scler

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Zang, Yichao, Zhihong Cheng, and Tao Wu. "TLC Bioautography on Screening of Bioactive Natural Products: An Update Review." Current Analytical Chemistry 16, no. 5 (2020): 545–56. http://dx.doi.org/10.2174/1573411015666181224145346.

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Background: TLC bioautography is a hyphenated technique combining planar chromatographic separation and in situ biological activity detection. This coupled method has been receiving much attention in screening bio-active natural products because of its properties of being simple, rapid, inexpensive, and effective. Methods: The recent progress in the development of method of TLC bioautography for detecting antimicrobial and enzyme inhibitory activities dating between 2012 and early 2018 has been reviewed. The applications of this method in biological screening of natural products were also pres

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Young, Katherine, Hiranthi Jayasuriya, John G. Ondeyka, et al. "Discovery of FabH/FabF Inhibitors from Natural Products." Antimicrobial Agents and Chemotherapy 50, no. 2 (2006): 519–26. http://dx.doi.org/10.1128/aac.50.2.519-526.2006.

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ABSTRACT Condensing enzymes are essential in type II fatty acid synthesis and are promising targets for antibacterial drug discovery. Recently, a new approach using a xylose-inducible plasmid to express antisense RNA in Staphylococcus aureus has been described; however, the actual mechanism was not delineated. In this paper, the mechanism of decreased target protein production by expression of antisense RNA was investigated using Northern blotting. This revealed that the antisense RNA acts posttranscriptionally by targeting mRNA, leading to 5′ mRNA degradation. Using this technology, a two-pla

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Davies-Bolorunduro, Olabisi Flora, Abraham Ajayi, Isaac Adeyemi Adeleye, Alfinda Novi Kristanti, and Nanik Siti Aminah. "Bioprospecting for antituberculosis natural products – A review." Open Chemistry 19, no. 1 (2021): 1074–88. http://dx.doi.org/10.1515/chem-2021-0095.

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Abstract There has been an increase in the reported cases of tuberculosis, a disease caused by Mycobacterium tuberculosis, which is still currently affecting most of the world’s population, especially in resource-limited countries. The search for novel antitubercular chemotherapeutics from underexplored natural sources is therefore of paramount importance. The renewed interest in studies related to natural products, driven partly by the growing incidence of MDR-TB, has increased the prospects of discovering new antitubercular drug leads. This is because most of the currently available chemothe

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Schenk, T., G. J. Breel, P. Koevoets, et al. "Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization." Journal of Biomolecular Screening 8, no. 4 (2003): 421–29. http://dx.doi.org/10.1177/1087057103255973.

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The ability to rapidly identify active compounds in a complex mixture (e.g., natural products extract) is still one of the major problems in natural products screening programs. An elegant way to overcome this problem is to separate the complex mixture by gradient liquid chromatography followed by online biochemical detection parallel with chemical characterization, referred to as high-resolution screening (HRS). To find and identify phosphodiesterase (PDE) inhibitors in natural products extracts using the HRS technology, the authors developed a continuous-flow PDE enzymatic assay. The suitabi

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Bootyothee, Kanokwan, Surasit Aunpromma, Atchara Artchayasawat, Opal Pitaksakulrat, Sirintip Boonjaraspinyo, and Thidarut Boonmars. "Screening of natural product extracts for fly repellent and larvicide." Veterinary Integrative Sciences 20, no. 1 (2021): 25–40. http://dx.doi.org/10.12982/vis.2022.003.

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Fly is one of the vectors of foodborne pathogenic vectors and causes myiasis in humans and animals. To prevent the contamination of food and myiasis, various chemical products are commonly used. However, eco-friendly is now a trend all over the world so natural products are the alternative ways to reduce the chemical residue in the environment. The present study was screened the 12 natural products in 4 groups; the essential oil plants, the alkaloid plants, the cyanogenic plant, and the inorganic compounds which use a simple extraction on the fly repelling and larvicide. The fly repelling effi

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Karaman Mayack, Berin, Wolfgang Sippl, and Fidele Ntie-Kang. "Natural Products as Modulators of Sirtuins." Molecules 25, no. 14 (2020): 3287. http://dx.doi.org/10.3390/molecules25143287.

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Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developm

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Medina-Franco, José L., and Fernanda I. Saldívar-González. "Cheminformatics to Characterize Pharmacologically Active Natural Products." Biomolecules 10, no. 11 (2020): 1566. http://dx.doi.org/10.3390/biom10111566.

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Natural products have a significant role in drug discovery. Natural products have distinctive chemical structures that have contributed to identifying and developing drugs for different therapeutic areas. Moreover, natural products are significant sources of inspiration or starting points to develop new therapeutic agents. Natural products such as peptides and macrocycles, and other compounds with unique features represent attractive sources to address complex diseases. Computational approaches that use chemoinformatics and molecular modeling methods contribute to speed up natural product-base

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Mok, So-Youn, Hyun-Cheol Shin, and Sang-Hyun Lee. "Screening of aldose reductase inhibitory activity of white-color natural products." CNU Journal of Agricultural Science 39, no. 1 (2012): 69–73. http://dx.doi.org/10.7744/cnujas.2012.39.1.069.

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Konc, Janez. "Identification of neurological disease targets of natural products by computational screening." Neural Regeneration Research 14, no. 12 (2019): 2075. http://dx.doi.org/10.4103/1673-5374.262576.

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