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Artigos de revistas sobre o tema "Site of ongoing repair"

Autor: Grafiati

Publicado: 28 de maio de 2022

Última modificação: 30 de julho de 2025

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1

Jung, Ju Yeon, Tom Steinberger, John L. King, and Mark S. Ackerman. "Negotiating Repairedness: How Artifacts Under Repair Become Contingently Stabilized." Proceedings of the ACM on Human-Computer Interaction 5, CSCW2 (2021): 1–29. http://dx.doi.org/10.1145/3476069.

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This paper examines "repairedness" - the contingently stable, working version of an artifact under repair that is negotiated out of multiple possible versions to bring about the temporary conclusion of repair work. Our paper draws on an ethnographic study of an analog electronics repair community in Seoul, South Korea to develop two contributions. First, studying processes of negotiating the repairedness of an artifact accounts for contingency in the properties of the artifact itself, which differs from contingencies in collaborative work practices that have been a focus of CSCW research on re

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Skazlić, Marijan, Berislav Borovina, and Ivan Gabrijel. "Optimised technology for repair of vertical surface of concrete bridge elements." Organization, Technology and Management in Construction: an International Journal 15, no. 1 (2023): 233–42. http://dx.doi.org/10.2478/otmcj-2023-0018.

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Abstract A large number of concrete bridges need to be repaired due to durability problems. This research focuses on evaluating the bond quality of the repair material, which has the highest influence on the durability of the repair. Onsite experimental research is performed on the vertical surfaces of the column of the Klara Jug bridge, which is located in the southern part of the Zagreb. Since the experimental research is carried out in parallel with the ongoing repair works on other bridge elements, the experimental conditions correspond to the real construction site conditions. Simulation

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Desai, Salomi, and Chathuraka T. Jayasuriya. "Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair." Bioengineering 7, no. 3 (2020): 86. http://dx.doi.org/10.3390/bioengineering7030086.

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Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast majority of these methodologies can ultimately be categorized into two main approaches: (1) Facilitating the recruitment of endogenous host cells to the injury site; and (2) physically administering into the injury site cells themselves, exogenously, either by autologous or allogeneic implantation. The aim of this paper is to comprehensively r

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Chakarov, Stoyan, Rumena Petkova, and George Ch Russev. "DNA repair systems." BioDiscovery 13 (September 22, 2014): e8961. https://doi.org/10.7750/BioDiscovery.2014.13.2.

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This paper provides detailed insight into the mechanisms of repair of different types of DNA damage and the direct molecular players (enzymes repairing the damage or tagging the damaged site for further processing; damage sensor molecules; other signalling and effector molecules). The genetic bases of diseases and conditions associated with defective DNA repair are comprehensively reviewed, from the ''classic'' severe diseases such as xeroderma pigmentosum and Cockayne syndrome to the much more subtle UV sensitivity syndromes. The review analyses the basic molecular mechanisms underlying the r

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Strassler, Karen. "The art of repair: naming violence in the work of FX Harsono." Journal of Visual Culture 21, no. 1 (2022): 165–89. http://dx.doi.org/10.1177/14704129221088292.

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Since the end of authoritarian rule in Indonesia in 1998 and the anti-Chinese violence that attended it, the artist FX Harsono has created a series of works addressing the name as a site of racialized state violence, cultural identity, erasure, recovery, and repair. Through an examination of Harsono’s works, this article asks: How can art put forward a reparative vision in a context of impunity, forgetting, and ongoing discrimination? How do the sonic and visual qualities of ethnic Chinese names register affective claims of resilience and survival against a backdrop of violence and loss? Rathe

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Dandu, Navya, Nicholas A. Trasolini, Steven F. DeFroda, Tai Holland, and Adam B. Yanke. "Revision Quadriceps Tendon Repair With Bone-Achilles Allograft Augmentation." Video Journal of Sports Medicine 1, no. 6 (2021): 263502542110326. http://dx.doi.org/10.1177/26350254211032680.

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Background: Surgical repair of chronic quadriceps tendon ruptures can be daunting, especially after failure of a prior repair. In this setting, tissue quality is usually poor, necessitating graft augmentation. In this video, we describe our technique for Achilles tendon allograft augmentation for revision quadriceps tendon repair. Indications: Failed quadriceps tendon repair defined as ongoing extensor mechanism deficit including patella baja, functional deficit, or palpable quadriceps defect with confirmed retear on advanced imaging. Technique Description: Patient is placed in the supine posi

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Furkan, Ozan. "Improving orthopedic use of stem cell engineering: A mini-review." Ulus Medical Journal 1, no. 1 (2023): 9–11. https://doi.org/10.5281/zenodo.7905315.

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Cell-based therapies for cartilage regeneration have gained popularity as a potential solution to the ongoing problem of articular cartilage repair in orthopedic surgery. There have been some successes with autologous chondrocyte implantation, but there are also some drawbacks. These include limited donor sites, donor site morbidity, dedifferentiation of isolated chondrocytes during monolayer expansion, and poor integration of repair tissue into the native cartilage. The potential of mesenchymal stem cells (MSCs) as a replacement cell source has so gained popularity. Self-renewing, highly expa

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Pritchard, D., M. Griffo, M. Attenni, et al. "EVOLUTION OF RECORDING METHODS: THE AACHEN CATHEDRAL WORLD HERITAGE SITE DOCUMENTATION PROJECT." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-M-2-2023 (June 26, 2023): 1241–49. http://dx.doi.org/10.5194/isprs-archives-xlviii-m-2-2023-1241-2023.

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Abstract. Modern terrestrial laser scanners and photogrammetric imaging systems can provide highly accurate and objective as-built records of existing architectural, engineering, and industrial sites. This comprehensive digital recording benefits culturally significant places like heritage buildings, monuments, and other vital structures. The collected data can be instrumental in various ways, including aiding in conservation, management, monitoring and repair efforts and serving as an educational resource for scholars and the general public. These technical capabilities are especially well-su

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DeNoto, George, Eugene P. Ceppa, Salvatore J. Pacella, et al. "A Prospective, Single Arm, Multi-Center Study Evaluating the Clinical Outcomes of Ventral Hernias Treated with OviTex® 1S Permanent Reinforced Tissue Matrix: The BRAVO Study 12-Month Analysis." Journal of Clinical Medicine 10, no. 21 (2021): 4998. http://dx.doi.org/10.3390/jcm10214998.

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Background: Conflicting results from previous studies have led to dissent over whether surgical mesh is safe and effective in ventral hernia repair. A newer class of mesh known as a reinforced tissue matrix, combining a biologic scaffold and minimal polymer reinforcement, offers promise in reducing inflammatory response and increasing abdominal wall support. This study sought to assess the clinical utility of a reinforced tissue matrix (OviTex) in ventral hernia repair 12 months after implantation. Methods: This is a prospective, single-arm, multi-center study to evaluate the clinical performa

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Dobke, Marek. "Case Report: Treatment of a Lower Leg Defect in the Course of Sarcoma With Microvascular Tissue." Wounds: a compendium of clinical research and practice 35, no. 5 (2023): e154-e159. http://dx.doi.org/10.25270/wnds/22073.

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Introduction. During normal wound healing, angiogenesis leads to re-establishment of a functioning microcirculation to deliver oxygen and nutrients required for clinically effective tissue repair. In refractory wounds, however, this process can be severely compromised due to insufficient vascularity and resulting senescent microenvironment. Case Report. This case report follows a patient undergoing aggressive chemotherapy and neoadjuvant radiotherapy who presented with a complicated 25 cm2 left leg wound and exposed tibial bone after failed skin grafting and advanced biologic treatment. PMVT,

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Walters, Denise K., Renee C. Tschumper, Xiaosheng Wu, Kimberly J. Henderson, Angela Dispenzieri, and Diane F. Jelinek. "Evidence for Ongoing DNA Damage in Multiple Myeloma as Revealed by Constitutive Phosphorylation of H2AX." Blood 114, no. 22 (2009): 2817. http://dx.doi.org/10.1182/blood.v114.22.2817.2817.

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Abstract Abstract 2817 Poster Board II-793 Abnormal plasma cells (PC) present in patients with multiple myeloma (MM) and its precursor condition, monoclonal gammopathy of undetermined significance (MGUS), characteristically possess multiple chromosomal abnormalities. Moreover, both stages of disease exhibit considerable intratumor heterogeneity, which often becomes even more complex during disease progression. The precise mechanism(s) underlying this process remains unknown. However, we hypothesize that DNA double-strand breaks (DSBs) and compromised repair of these deleterious lesions may und

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Xu, Junjie, Yufeng Li, Zipeng Ye, et al. "Biceps Augmentation Outperforms Tear Completion Repair or In Situ Repair for Bursal-Sided Partial-Thickness Rotator Cuff Tears in a Rabbit Model." American Journal of Sports Medicine 50, no. 1 (2021): 195–207. http://dx.doi.org/10.1177/03635465211053334.

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Background: There is an ongoing debate on the treatment of bursal-sided partial-thickness rotator cuff tears (PTRCTs), including ideal repair techniques. Augmentation using a collagen patch has been introduced as a new surgical approach to treat PTRCTs, while the effect of autogenous biceps augmentation (BA) has not been investigated. Purpose: To analyze the effects of BA on bursal-sided PTRCTs and compare its histological and biomechanical results with those of tear completion followed by repair and in situ repair (ISR). Study Design: Controlled laboratory study. Methods: Unilateral chronic P

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Postma, Albert, and Herman Kolk. "The Covert Repair Hypothesis." Journal of Speech, Language, and Hearing Research 36, no. 3 (1993): 472–87. http://dx.doi.org/10.1044/jshr.3603.472.

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Self-repairing of speech errors demonstrates that speakers possess a monitoring device with which they verify the correctness of the speech flow. There is substantial evidence that this speech monitor not only comprises an auditory component (i.e., hearing one’s own speech), but also an internal part: inspection of the speech program prior to its motoric execution. Errors thus may be detected before they are actually articulated. In the covert repair hypothesis of disfluency, this internal error detection possibility has been extended with an internal correction counterpart. Basically, the cov

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Durocher, D. "Abstract MS1-1: CRISPR screens to identify novel DNA repair defects synthetic lethal therapies." Cancer Research 82, no. 4_Supplement (2022): MS1–1—MS1–1. http://dx.doi.org/10.1158/1538-7445.sabcs21-ms1-1.

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Abstract The orchestration of DNA repair is of fundamental importance to the maintenance of genomic integrity and tumor suppression. DNA damage must be detected in the context of the varied chromatin landscape, its presence must be communicated throughout the cell to alter many ongoing processes, and the machinery that will mend the lesion must be recruited to the damage site. In my presentation, I will discuss our recent efforts in mapping genome maintenance pathways using genome-scale CRISPR/Cas9 screens in human cells. I will highlight how these screens can also identify potentially actiona

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Kumar, Abhishek, Nagarajan Paramasivam, Obul Reddy Bandapalli, et al. "A rare large duplication of MLH1 identified in Lynch syndrome." Hereditary Cancer in Clinical Practice 19, no. 1 (2021): 1–7. https://doi.org/10.1186/s13053-021-00167-0.

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<strong>Background: </strong>The most frequently identified strong cancer predisposition mutations for colorectal cancer (CRC) are those in the mismatch repair (MMR) genes in Lynch syndrome. Laboratory diagnostics include testing tumors for immunohistochemical staining (IHC) of the Lynch syndrome-associated DNA MMR proteins and/or for microsatellite instability (MSI) followed by sequencing or other techniques, such as denaturing high performance liquid chromatography (DHPLC), to identify the mutation. <strong>Methods: </strong>In an ongoing project focusing on finding Mendelian cance

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Kutty, Shelby, David A. Danford, Gerhard-Paul Diller, and Oktay Tutarel. "Contemporary management and outcomes in congenitally corrected transposition of the great arteries." Heart 104, no. 14 (2018): 1148–55. http://dx.doi.org/10.1136/heartjnl-2016-311032.

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Congenitally corrected transposition of the great arteries (ccTGA) can occur in isolation, or in combination with other structural cardiac anomalies, most commonly ventricular septal defect, pulmonary stenosis and tricuspid valve disease. Clinical recognition can be challenging, so echocardiography is often the means by which definitive diagnosis is made. The tricuspid valve and right ventricle are on the systemic arterial side of the ccTGA circulation, and are therefore subject to progressive functional deterioration. The natural history of ccTGA is also greatly influenced by the nature and s

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Uchida, Mayuka, Aiko Oka, Shiho Watanabe, and Hiroko Ochiai. "Tracheal Reconstruction With a Clavicle-attached Sternocleidomastoid Muscle Flap Tolerant to Positive Pressure Ventilation." Plastic and Reconstructive Surgery - Global Open 13, no. 2 (2025): e6501. https://doi.org/10.1097/gox.0000000000006501.

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Summary: Posttracheostomy wound allows for spontaneous closure of the fistula once it is no longer needed. However, a surgical closure is required when closure does not occur spontaneously. To date, only cases involving patients with spontaneous respiration have been reported. Here, we report successful treatment of a 29-year-old man with extensive tracheal wall tissue defects after tracheostomy, which allowed for the continuation of noninvasive positive pressure ventilation (NPPV) therapy. In this case, the patient presented with loss of spontaneous breathing resulting due to a cervical 4 (C4

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Tinica, Grigore, Andrei Tarus, Alberto Bacusca, et al. "Hybrid Management of an Aortobronchial Fistula after Patch Aortoplasty for Aortic Coarctation in a Patient with SARS-CoV-2 Pneumonia: Case Report and Review of the Literature." Medicina 58, no. 10 (2022): 1385. http://dx.doi.org/10.3390/medicina58101385.

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Aortobronchial fistula is a rare cause of repeated hemoptysis and a potentially fatal condition if left untreated. We present the case of a 40-year-old man with repeated hemoptysis, excessive cough, and epistaxis ongoing for several days after SARS-CoV-2 pneumonia diagnosis. The patient had a history of patch aortoplasty for aortic coarctation and aortic valve replacement with a mechanical valve for aortic insufficiency due to bicuspid aortic valve at the age of 24. Computed tomography scan performed at presentation revealed a severely dilated ascending aorta, a thoracic aorta pseudoaneurysm a

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Kozlov, V. B., A. B. Istomin, and I. N. Gemba. "Repair and restoration of shafts, couplings, splined and keyed joints." Glavnyj mekhanik (Chief Mechanic), no. 7 (June 11, 2021): 32–42. http://dx.doi.org/10.33920/pro-2-2107-03.

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The article provides an overview of the methods of restoration and repair of various parts of the equipment: shafts, couplings, splined and keyed joints. Recommendations on the choice of methods, equipment and tools are given. In case of wear, the keyway is repaired by welding the face with subsequent milling. At the same time, the keyway size set by the standard is maintained. Such repairs are also possible: the keyway is expanded and deepened, completely eliminating the traces of wear, after which a stepped key is made to it. However, with such repairs, a high-quality connection is not provi

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Knicely, Breanna. "Abstract 1500: Exonuclease 1 recruitment in human DNA mismatch repair." Cancer Research 82, no. 12_Supplement (2022): 1500. http://dx.doi.org/10.1158/1538-7445.am2022-1500.

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Abstract DNA repair is the process by which cells identify and correct mutations present within the genome. These correction mechanisms maintain genomic stability and prevent the development of cancer. The DNA mismatch repair (MMR) pathway identifies and corrects small insertions, deletions, and misincorporations that arise within the genome as a result of errors during DNA replication. The process by which MMR corrects these mispairs includes recognition of the mispair by the MutS complex, recruitment of the MutL complex to the mutation site, excision of the mispair, and gap filling by DNA po

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Patel, Shyam. "How to Read When the World is on Fire." Studies in Social Justice 18, no. 4 (2024): 893–902. https://doi.org/10.26522/ssj.v18i4.4375.

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As Mishra Tarc (2020) does through her evocative words on engaging texts today, I contemplate how texts, specifically children’s books, open pedagogical possibilities to reckon, repair, and reworld in a world that is on fire. From climate change to racial justice, it is children’s books, I believe, that can serve as pedagogical interventions and responses for teachers and teacher educators who are interested in addressing and confronting these complex and sometimes ineffable issues. I offer a glimpse of this approach through my practice as an elementary school teacher, a teacher candidate, and

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Muir, Keith W. "Stem cells in stroke management." Reviews in Clinical Gerontology 21, no. 2 (2010): 125–40. http://dx.doi.org/10.1017/s0959259810000390.

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SummaryStem cells are a potential means of tissue regeneration in the brain that hold promise for treatment of the large number of stroke survivors who have permanent disability. Animal studies with stem cells derived from many different sources indicate that cells can migrate to the site of ischaemic injury in the brain, and that some survive and differentiate into neurones and glia with evidence of electrical function. Cells additionally promote endogenous repair mechanisms, including mobilization of neural stem cells resident within the adult brain. Whether the behavioural benefits seen wit

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Reichenpfader, Ursula, Anette Wickström, Madeleine Abrandt Dahlgren, and Siw Carlfjord. "Embedding hospital-based medication review." Journal of Health Organization and Management 33, no. 3 (2019): 339–52. http://dx.doi.org/10.1108/jhom-09-2018-0268.

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Purpose The purpose of this paper is to explore the embedding of hospital-based medication review attending to the conflictual and developmental nature of practice. Specifically, this paper examines manifestations of contradictions and how they play out in professional practices and local embedding processes. Design/methodology/approach Using ethnographic methods, this paper employs the activity-theoretic notion of contradictions for analyzing the embedding of medication review. Data from participant observation (in total 290 h over 48 different workdays) and 31 semi-structured interviews with

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Schneider, Cheyenne A., Tin-Yu Lin, Aimee Falzone, Samantha Caldwell, Jared L. Johnson, and Gina M. DeNicola. "Abstract 309: ATM phosphorylation of NRF2 promotes DNA damage repair." Cancer Research 83, no. 7_Supplement (2023): 309. http://dx.doi.org/10.1158/1538-7445.am2023-309.

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Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that responds to cellular and oxidative stress by promoting the transcription of antioxidant response element-containing genes. In an unstressed cellular environment, NRF2 is bound by Kelch-like ECH-associated protein 1 (KEAP1) and tagged for proteasomal degradation. In many cancers, the interaction between NRF2 and KEAP1 is interrupted due to mutations in either protein. Previous work has suggested that NRF2 can promote DNA damage repair, and our preliminary data demonstrates that NRF2 is phosphorylated at S

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Vasile, Mihai Alexandru, Victor Stefanescu, Cezar Betianu, Andrei Neagu, Alexandru Bucur, and Sabrina Florea. "The posterior component separation technique in the repair of parietal defects – An overview of existing evidence." Romanian Medical Journal 72, no. 1 (2025): 146–57. https://doi.org/10.37897/rmj.2025.1.20.

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Introduction. Hernias, particularly complex parietal defects, pose significant surgical challenges. The transversus abdominis release (TAR) technique enables the creation of an enlarged retromuscular-preperitoneal space for mesh placement while preserving vascularization, addressing limitations of traditional methods. Despite its benefits—such as reduced morbidity and improved outcomes—complications can arise, and ongoing discussions persist regarding the procedure’s optimization based on patient-specific factors. Materials and methods. This retrospective narrative review involved a systematic

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Halder, Kalpataru. "Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis." International Journal of Advancement in Life Sciences Research 07, no. 02 (2024): 17–40. http://dx.doi.org/10.31632/ijalsr.2024.v07i02.003.

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Chemotherapy resistance indicates the non-responsiveness of cancer cells to the cytotoxic and inhibitory effects of chemo drugs attributed to either intrinsic or extrinsic resistance mechanisms in cancer cells. Studies so far indicate that drug resistance can be triggered by a multitude of factors such as the over-expression of drug efflux pumps, DNA repair mechanisms, modifications in the drug target such as point mutations and gene amplification, over-expression of anti-apoptotic proteins and down-regulation of pro-apoptotic signals, presence of cancer stem cells and immune-suppressive cells

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Durocher, Daniel. "Abstract IA003: Synthetic lethality: Pathways to therapeutic discovery." Molecular Cancer Therapeutics 23, no. 12_Supplement (2024): IA003. https://doi.org/10.1158/1538-8514.cancerchem24-ia003.

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The orchestration of DNA repair is of fundamental importance to the maintenance of genomic integrity and tumor suppression. DNA damage must be detected in the context of the varied chromatin landscape, its presence must be communicated throughout the cell to alter many ongoing processes, and the machinery that will mend the lesion must be recruited to the damage site. In my presentation, I will discuss our recent efforts in mapping genome maintenance pathways using genome-scale CRISPR/Cas9 screens in human cells. I will highlight how these screens can be used to identify new genome stability f

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Khashkhusha, Arwa, Sundas Butt, Mariam Abdelghaffar, et al. "Sternal Wound Reconstruction Following Deep Sternal Wound Infection: Past, Present and Future: A Literature Review." Journal of Cardiovascular Development and Disease 11, no. 11 (2024): 361. http://dx.doi.org/10.3390/jcdd11110361.

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This literature review critically examines the historical, current, and prospective dimensions of sternal wound reconstruction in the specific context of deep sternal wound infection (DSWI), aiming to enhance patient outcomes and optimise surgical techniques. Preventive measures, including prophylactic antibiotic administration and surgical site preparation, are crucial in reducing the incidence of DSWI. Effective management necessitates a multidisciplinary approach encompassing surgical debridement, drainage, and sternum repair utilising diverse procedures in conjunction with antibiotic thera

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Lepere, M., J. F. Gillion, C. Barrat, et al. "First Year Preliminary Results on the Use of a Monofilament Polyester Mesh With a Collagen Barrier for Primary and Incisional Ventral Hernia Repair." International Surgery 103, no. 1-2 (2019): 56–65. http://dx.doi.org/10.9738/intsurg-d-17-00113.1.

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Aim: The SymCHro study objective is to assess patient outcomes and surgeon satisfaction following ventral hernia repair with a three-dimensional (3D) monofilament polyester mesh (Symbotex composite mesh) that contains an absorbable collagen barrier on 1 side to minimize tissue attachment. Methods: SymCHro is a multicenter observational study of 100 consecutive patients in the French Club Hernie registry who underwent primary and incisional ventral hernia repair with a Symbotex composite mesh. The primary objective is to assess recurrences and complications within 2 years of repair. This analys

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Shammas, Masood A., Robert C. Bertheau, Hemanta Koley, et al. "Elevated Apurinic/Apyrimidinic Endonuclease Activity Significantly Contributes to DNA Instability in Multiple Myeloma." Blood 108, no. 11 (2006): 2077. http://dx.doi.org/10.1182/blood.v108.11.2077.2077.

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Abstract Apurinic/apyrimidic (AP) sites are the commonest DNA damage lesions and are highly mutagenic and cytotoxic requiring immediate repair. AP endonucleases (APE) 1 and 2 are the key proteins involved in the repair of AP sites and therefore play an important role in maintaining genomic integrity. However, if APE activity is dysregulated, it may lead to increase in DNA breaks leading to genomic rearrangements. In this study we demonstrate that endonuclease activity as measured by a novel plasmid based assay is elevated over 5 fold in myeloma cell lines and primary myeloma cells relative to

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Manz, Salomon M., Marco Losa, Ralph Fritsch, and Michael Scharl. "Efficacy and side effects of immune checkpoint inhibitors in the treatment of colorectal cancer." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110020. http://dx.doi.org/10.1177/17562848211002018.

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Colorectal cancers (CRCs) remain one of the most common and challenging neoplasia in the Western world. The response rate of immunotherapeutic treatment approaches in a subset of advanced CRCs is remarkable and has sustainably changed treatment regimens. Unfortunately, currently available immunotherapeutics only displayed significant antitumoral activity – in terms of progression free survival (PFS) and objective response rate (ORR) – in microsatellite instability-high (MSI-H)/DNA mismatch repair deficient (dMMR) CRCs. Subsequently, these remarkable results had led to the US Food and Drug Admi

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Wang, Wenjie, and Yuk-Ching Tse-Dinh. "Recent Advances in Use of Topoisomerase Inhibitors in Combination Cancer Therapy." Current Topics in Medicinal Chemistry 19, no. 9 (2019): 730–40. http://dx.doi.org/10.2174/1568026619666190401113350.

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Inhibitors targeting human topoisomerase I and topoisomerase II alpha have provided a useful chemotherapy option for the treatment of many patients suffering from a variety of cancers. While the treatment can be effective in many patient cases, use of these human topoisomerase inhibitors is limited by side-effects that can be severe. A strategy of employing the topoisomerase inhibitors in combination with other treatments can potentially sensitize the cancer to increase the therapeutic efficacy and reduce resistance or adverse side effects. The combination strategies reviewed here include inhi

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Kohn, Donald B. "Eliminating SCID row: new approaches to SCID." Hematology 2014, no. 1 (2014): 475–80. http://dx.doi.org/10.1182/asheducation-2014.1.475.

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Abstract Treatments for patients with SCID by hematopoietic stem cell transplantation (HSCT) have changed this otherwise lethal primary immune deficiency disorder into one with an increasingly good prognosis. SCID has been the paradigm disorder supporting many key advances in the field of HSCT, with first-in-human successes with matched sibling, haploidentical, and matched unrelated donor allogeneic transplantations. Nevertheless, the optimal approaches for HSCT are still being defined, including determining the optimal stem cell sources, the use and types of pretransplantation conditioning, a

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Ma-Van-de, А. Yu, Е. V. Fefelova, and Yu A. Shirshov. "THE ROLE OF INDIVIDUAL NEUROINFLAMMATION MOLECULES IN PATHOGENESIS ISCHEMIC STROKE. PART I." Transbaikalian Medical Bulletin, no. 1 (May 18, 2024): 139–47. http://dx.doi.org/10.52485/19986173_2024_1_139.

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Ischemic stroke is an acute, severe vascular pathology of the brain, accompanied by general cerebral and focal neurological symptoms. The occurrence of the disease is based on arterial thrombosis, leading to the formation of a focus of infarction of brain tissue. In most cases, after an acute cerebral accident, persistent neurological deficits persist in the form of motor, cognitive and other disorders. Cerebral infarction is a multifactorial disease with a complex multicascade pathogenesis. The severity of the disease, the speed of patient recovery and outcome do not always correlate with the

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Morishige, Satoshi, Hidetoshi Ozawa, Shinichi Mizuno, et al. "CRISPR/Cas9 Mediated Gene Repair in Inherited Bleeding Disorders." Blood 126, no. 23 (2015): 3240. http://dx.doi.org/10.1182/blood.v126.23.3240.3240.

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Abstract [Introduction] Inherited bleeding disorders (IBD), such as coagulation factor deficiencies, Von Willebrand disease and Glanzmann thrombasthenia, are caused by various gene abnormalities of coagulation proteins, blood vessels, and platelets. IBD have been considered to be suited for gene therapy and clinical trials are ongoing. However, the safety and effectiveness of viral vectors has not been established. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system, originates from the archaeal and bacterial adaptive immunity

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Jacoby, Meagan A., Rigoberto de Jesus, and Matthew J. Walter. "Dysfunctional Double-Strand DNA Break Repair In Primary t-AML/t-MDS Myeloblasts." Blood 116, no. 21 (2010): 3366. http://dx.doi.org/10.1182/blood.v116.21.3366.3366.

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Abstract Abstract 3366 The gross chromosomal aberrations in treatment-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/t-MDS) cells suggest that disease initiation and progression may result from the inability of cells to appropriately respond to double-strand DNA breaks (DSBs) induced by prior exposure to radiation, alkylator, or topoisomerase II inhibitor therapy. We hypothesize that dysregulation of DSB repair by homology-directed repair (HDR) or nonhomologous end joining (NHEJ) contributes to the development of t-AML/t-MDS. Dysregulation of DSB repair in t-AML/t-MDS may resul

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Lam, Grace, Vivek Mehta, and Gabriel Zada. "Spontaneous and medically induced cerebrospinal fluid leakage in the setting of pituitary adenomas: review of the literature." Neurosurgical Focus 32, no. 6 (2012): E2. http://dx.doi.org/10.3171/2012.4.focus1268.

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Object Spontaneous and medically induced CSF leaks are uncommonly associated with pituitary adenomas. The aim of this study was to further characterize the clinical scenarios most closely associated with this phenomenon. Methods A review of the literature was conducted to identify all cases of nonsurgical CSF leaks associated with pituitary adenomas. The authors aimed to identify associated risk factors and management strategies used to treat these tumors and repair the CSF leak site. Results Fifty-two patients with spontaneous or medically induced CSF leaks in the setting of a pituitary adeno

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Martín, Diana, and Engin Seyhan. "Protection of Reinforced Concrete Steel Exposed to a Marine Environment: A Preliminary Onsite Study of the Performance of a New Generation of Surface-Applied Corrosion Inhibitors." Corrosion and Materials Degradation 3, no. 4 (2022): 628–45. http://dx.doi.org/10.3390/cmd3040034.

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Reinforcement corrosion is the risk most frequently cited to justify concrete durability research, especially where it is induced by chlorides. Surface-applied corrosion inhibitors are widely used to mitigate the corrosion process both for carbonation and chlorides of steel reinforcement in concrete. They are applied onto the surface of hardened concrete and penetrate towards steel reinforcement. This paper discusses the corrosion inhibition performance of a new generation of a dual-phase surface-applied corrosion inhibitor (DP-SACI), and its efficiency in corrosion induced by chlorides over 3

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Husted, Steen, Lars Wallentin, Felicita Andreotti, et al. "Parenteral anticoagulants in heart disease: Current status and perspectives (Section II)." Thrombosis and Haemostasis 109, no. 05 (2013): 769–86. http://dx.doi.org/10.1160/th12-06-0403.

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SummaryAnticoagulants are a mainstay of cardiovascular therapy, and parenteral anticoagulants have widespread use in cardiology, especially in acute situations. Parenteral anticoagulants include unfractionated heparin, low-molecular-weight heparins, the synthetic pentasaccharides fondaparinux, idraparinux and idrabiotaparinux, and parenteral direct thrombin inhibitors. The several shortcomings of unfractionated heparin and of low-molecular-weight heparins have prompted the development of the other newer agents. Here we review the mechanisms of action, pharmacological properties and side effect

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Gkotzamanidou, Maria, Masood A. Shammas, Vassilis L. Souliotis, et al. "Spontaneous DNA Damage and Aberrant Epigenome In Multiple Myeloma Constitute The Path To Disease Genomic Instability." Blood 122, no. 21 (2013): 4884. http://dx.doi.org/10.1182/blood.v122.21.4884.4884.

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Abstract Multiple Myeloma (MM) is a malignant, progressive tumor of clonal long-lived plasma cells and characterized by genomic heterogeneity that contributes to differences in prognosis and response rates of patients. Almost all MM patients are characterized by genomic abnormalities including chromosome number and structural variations. Mis - or unrepaired DNA double-strand breaks (DSBs) pose a serious threat to genomic stability, potentially leading to the formation of oncogenic mutations, including translocations, deletions and amplifications. We evaluated spontaneous DNA damage in a panel

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Cowzer, Darren, Emily O'Donovan, Therese Brown, Noreen Gleeson, and David James Gallagher. "Natural history of mucinous ovarian cancer in Ireland." Journal of Clinical Oncology 35, no. 15_suppl (2017): e17056-e17056. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e17056.

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e17056 Background: Mucinous ovarian neoplasmscan arise as benign, borderline or malignant disease. Primary mucinous epithelial ovarian carcinoma (mEOC) represents 3% of invasive EOC. Differentiating primary from metastatic mucinous ovarian cancer is challenging. Systemic management of mucinous ovarian cancer increasingly follow GI cancer treatment protocols. We examined retrospective data at our institution to investigate incidence, management and site of origin of mEOC. Methods: 1,333 ovarian malignancies either diagnosed at or referred to St James Hospital, Dublin (from 2000 – 2016) were eva

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Hoban, Megan D., Alok V. Joglekar, David Gray та ін. "Zinc Finger Nucleases Targeting The β-Globin Locus Drive Efficient Correction Of The Sickle Mutation In CD34+ Cells". Blood 122, № 21 (2013): 2904. http://dx.doi.org/10.1182/blood.v122.21.2904.2904.

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Abstract Despite major improvements in clinical care and advances in understanding of its complex pathophysiology, sickle cell disease (SCD) continues to be a significant cause of morbidity and early mortality. Allogeneic hematopoietic stem cell transplant (HSCT) can benefit patients with SCD, by providing a source for life-long production of normal red blood cells. However, allogeneic HSCT is limited by the availability of well-matched donors and the immunological complications of graft rejection and graft-versus-host disease that can occur, especially for the more than 80% of patients who la

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Chaudry, Almas, Jinglei Wu, Hongsheng Wang, Xiumei Mo, M. Aqeel Bhutto, and Binbin Sun. "Research and application of conductive nanofiber nerve guidance conduits for peripheral nerve regeneration: a narrative review." Advanced Technology in Neuroscience 2, no. 1 (2025): 47–57. https://doi.org/10.4103/atn.atn-d-24-00024.

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Autologous nerve grafting has long been considered the gold standard treatment for repairing peripheral nerve injury. However, it faces challenges such as limited availability of donor nerves and complications at the donor site. As a result, there has been an ongoing shift toward the use of novel biomaterials. Conductive nanofiber nerve guidance conduits appear to be an optimal solution due to their excellent mechanical stability, nanofiber structure, and electrical stimulation properties, which can help restore the original neural microenvironment. This review article focuses on an in-depth i

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Riccò, Beatrice, Massimiliano Salati, Luca Reggiani Bonetti, Massimo Dominici, and Gabriele Luppi. "PD-1 blockade in deficient mismatch repair mixed adenoneuroendocrine carcinoma of the stomach: new hope for an orphan disease." Tumori Journal 106, no. 6 (2020): NP57—NP62. http://dx.doi.org/10.1177/0300891620952845.

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Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is an uncommon and aggressive tumor arising throughout the entire gastrointestinal tract. Treatment options are limited, and survival is dismal with conventional therapies. Case description: We present the case of a 66-year-old man who was diagnosed with a locally advanced MANEC of the gastroesophageal junction. He was treated with perioperative chemotherapy and total gastrectomy. After anastomotic tumor recurrence was detected, he underwent three systemic regimens, including chemoradiotherapy. The patient was then tested for mismatch r

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Chyra, Zuzana, Maria Gkotzamanidou, Masood A. Shammas, et al. "HDAC8 Maintain Cytoskeleton Integrity Via Homologous Recombination and Represent a Novel Therapeutic Target in Multiple Myeloma." Blood 134, Supplement_1 (2019): 4385. http://dx.doi.org/10.1182/blood-2019-130700.

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Multiple Myeloma (MM) is a plasma cell malignancy vulnerable to epigenetic intervention, with histone deacetylases (HDACs) emerging as the most promising epigenetic targets in combination with current anti-myeloma agents. Pan-HDAC inhibitors are effective as therapeutic agents both in preclinical and clinical setting; however, there is an increasing emphasis on understanding the biological and molecular roles of individual HDACs to limit toxicities observed with pan-HDAC inhibitors. Based on correlation with patient outcome in three independent myeloma datasets, we have evaluated the functiona

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Bannoura, Sahar F., Husain Y. Khan, Md Hafiz Uddin, et al. "Abstract 6876: A novel PCNA inhibitor AOH1996 demonstrates pre-clinical efficacy in pancreatic ductal adenocarcinoma models." Cancer Research 85, no. 8_Supplement_1 (2025): 6876. https://doi.org/10.1158/1538-7445.am2025-6876.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a dismal prognosis. It is the 9th most common cancer, and the 3rd leading cause of mortality in cancer patients in the United States. PDAC poses a significant clinical challenge partly due to advanced disease stage at diagnosis, poor response to chemotherapeutics, and common recurrence. Proliferating cell nuclear antigen (PCNA) is a ring-shaped clamp protein that encircles DNA and regulates replication and repair. Cancer cells depend on PCNA-mediated DNA repair, and transcription-replication conflict res

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Wang, Kemble K., Glenn Boyce, Tracy Peters, Hamish Anderson, and Greg Hoy. "Efficacy of Primary Repair in Professional Athletes with Chronic Radial Collateral Ligament Injuries of Thumb Metacarpophalangeal Joint." Journal of Hand Surgery (Asian-Pacific Volume) 24, no. 02 (2019): 138–43. http://dx.doi.org/10.1142/s2424835519500176.

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Background: Management of grade III injuries of the radial collateral ligament (RCL) of the thumb is controversial. These injuries are often treated with early surgery. However, early surgery may not be practical for the professional athlete. We report on the outcome of delayed primary repair of chronic RCL injuries without the use of tendon grafts or tendon transfers. Methods: Twelve elite professional athletes with 15 soft tissue RCL injuries who underwent delayed surgery (greater than 6 weeks) were included in this study. Athletes were managed with splinting and ongoing play during the spor

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Matei, Consuela Elena, Anita Ioana Visan, and Rodica Cristescu. "Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications." Polysaccharides 6, no. 2 (2025): 36. https://doi.org/10.3390/polysaccharides6020036.

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Aloe Vera (Aloe barbadensis Miller), a historically revered medicinal plant, has garnered great scientific attention due to its polysaccharide-rich bioactive compounds with significant therapeutic potential. This review examines the role of Aloe Vera polysaccharides as therapeutic agents in biomedical applications, highlighting their benefits as well as the risks. Traditionally recognized for its anti-inflammatory and antimicrobial effects, which are very important in wound healing, the Aloe Vera relies on its polysaccharides, which confer immunomodulatory, antioxidant, and tissue-regenerative

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Bucci, Gabriella, Michael Begg, Kevin Pillifant, and Steven B. Singleton. "Primary ACL Repair vs Reconstruction: Investigating the Current Conventional Wisdom." Orthopaedic Journal of Sports Medicine 6, no. 6_suppl3 (2018): 2325967118S0004. http://dx.doi.org/10.1177/2325967118s00049.

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BACKGROUND: “Why try to convert other collagen substitutes into ligament if the original can be preserved?” said Sherman1. Nowadays, reconstruction became the gold standard treatment for ACL injuries. Despite current treatment, secondary knee osteoarthritis has been described in more than 70% of the injured patients after 10 years follow up.2 Recent studies have reported that tears involving the proximal ACL have an intrinsic healing response. This response has been compared to the one observed in MCL injuries.3, 4. OBJECTIVE: The aim of this study is to initiate a scientific analysis of our e

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Chandran, Elias, Giovanni Maria Iannantuono, Dilara Akbulut, et al. "Mismatch repair deficiency and microsatellite instability-high in urothelial carcinoma: A systematic review and meta-analysis." Journal of Clinical Oncology 41, no. 16_suppl (2023): 4570. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.4570.

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4570 Background: Mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) occur in a small subset of urothelial carcinoma (UC) and confer a sensitivity to immunotherapy in multiple solid tumors. Due to the rarity of this patient subset in UC, there is a lack of prospective data on their prevalence or of clinical outcomes with immunotherapy and other treatment modalities. Methods: We performed a systematic review with the objectives of estimating the prevalence of dMMR and MSI-H in urothelial bladder cancer (BC) and upper tract urothelial carcinoma (UTUC) apart from estimat

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