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Artigos de revistas sobre o tema "SRD5A1"

Autor: Grafiati

Publicado: 15 de fevereiro de 2025

Última modificação: 28 de julho de 2025

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1

Khantham, Chiranan, Wipawadee Yooin, Korawan Sringarm, et al. "Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2." Biology 10, no. 4 (2021): 319. http://dx.doi.org/10.3390/biology10040319.

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Steroid 5-alpha reductases (SRD5As) are responsible for the conversion of testosterone to dihydrotestosterone, a potent androgen, which is the aetiologic factor of androgenetic alopecia. This study aimed to compare the SRD5A gene expression suppression activity exerted by Thai rice bran extracts and their components and investigate the interactional mechanism between bioactive compounds and SRD5A2 using molecular dynamics (MD) simulation. Bran of Oryza sativa cv. Tubtim Chumphae (TRB), Yamuechaebia Morchor (YRB), Riceberry (RRB), and Malinil Surin (MRB), all rice milling by-products, was solve

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Das, Kakoli, Pia D. N. Lorena, Lai Kuan Ng та ін. "Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer". Endocrine-Related Cancer 17, № 3 (2010): 757–70. http://dx.doi.org/10.1677/erc-10-0022.

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The biological role of steroid 5α-reductase isozymes (encoded by the SRD5A1 and SRD5A2 genes) and angiogenic factors that play important roles in the pathogenesis and vascularization of prostate cancer (PC) is poorly understood. The sub-cellular expression of these isozymes and vascular endothelial growth factor (VEGF) in PC tissue microarrays (n=62) was examined using immunohistochemistry. The effect of SRD5A inhibition on the angiogenesis pathway genes in PC was also examined in prostate cell lines, LNCaP, PC3, and RWPE-1, by treating them with the SRD5A inhibitors finasteride and dutasterid

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Goodarzi, Mark O., Nissar A. Shah, Heath J. Antoine, Marita Pall, Xiuqing Guo та Ricardo Azziz. "Variants in the 5α-Reductase Type 1 and Type 2 Genes Are Associated with Polycystic Ovary Syndrome and the Severity of Hirsutism in Affected Women". Journal of Clinical Endocrinology & Metabolism 91, № 10 (2006): 4085–91. http://dx.doi.org/10.1210/jc.2006-0227.

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Abstract Context: Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5α-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS). Objective: The objective of the study was to test the hypothesis that haplotypes in the SRD5A1 and SRD5A2 genes are risk factors for PCOS and the severity of hirsutism in affected women. Design: PCOS and control subjects were genotyped for seven single-nucleotide polymorphisms in SRD5A1 and eight single-nucleotide polymorphisms in SRD5A2. Haplotypes we

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Ruksiriwanich, Warintorn, Chiranan Khantham, Pichchapa Linsaenkart, et al. "In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients." Molecules 27, no. 5 (2022): 1535. http://dx.doi.org/10.3390/molecules27051535.

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Oily skin from overactive sebaceous glands affects self-confidence and personality. There is report of an association between steroid 5-alpha reductase gene (SRD5A) expression and facial sebum production. There is no study of the effect of Asparagus racemosus Willd. root extract on the regulation of SRD5A mRNA expression and anti-sebum efficacy. This study extracted A. racemosus using the supercritical carbon dioxide fluid technique with ethanol and investigated its biological compounds and activities. The A. racemosus root extract had a high content of polyphenolic compounds, including querce

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Chen, Erbao, Jing Yi, Qingqi Ren, Yuanna Mi, Zhe Gan, and Jikui Liu. "Overexpression of SRD5A3 in Hepatocellular Carcinoma and Its Molecular Mechanism: A Study of Bioinformatics Exploration Analysis with Experimental Verification." Evidence-Based Complementary and Alternative Medicine 2022 (September 16, 2022): 1–14. http://dx.doi.org/10.1155/2022/7853168.

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Background. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and more prevalent among males than females. However, the biological role of enzyme 5α-reductase (SRD5A3), which plays a critical role in the androgen receptor signaling pathway during HCC development, remains poorly understood. Methods. ONCOMINE, GEPIA, UALCAN, and Kaplan–Meier Plotter were used to analyze the expression and prognostic value of SRD5A3 in HCC. STRING and Metascape were applied to analyze potential target and molecular pathways underlying SRD5A3 in HCC. A real-time quantitative reverse trans

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Basaria, Shehzad, Ravi Jasuja, Grace Huang, et al. "Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss." Journal of Clinical Endocrinology & Metabolism 101, no. 12 (2016): 4669–80. http://dx.doi.org/10.1210/jc.2016-2726.

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Context: Some men who use finasteride for hair loss report persistent sexual and other symptoms after discontinuing finasteride therapy. Objective: To determine whether these persistent symptoms after discontinuation of finasteride use are due to androgen deficiency, decreased peripheral androgen action, or persistent inhibition of steroid 5α-reductase (SRD5A) enzymes. Participants: Finasteride users, who reported persistent sexual symptoms after discontinuing finasteride (group 1); age-matched finasteride users who did not report sexual symptoms (group 2); and healthy men who had never used f

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Melcangi, Roberto Cosimo, Livio Casarini, Marco Marino, et al. "Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study." Endocrine Connections 8, no. 8 (2019): 1118–25. http://dx.doi.org/10.1530/ec-19-0199.

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Context Post-finasteride syndrome (PFS) occurs in patients with androgenic alopecia after suspension of the finasteride treatment, leading to a large variety of persistent side effects. Despite the severity of the clinical picture, the mechanism underlying the PFS symptoms onset and persistence is still unclear. Objective To study whether epigenetic modifications occur in PFS patients. Methods Retrospective analysis of a multicentric, prospective, longitudinal, case–control clinical trial, enrolling 16 PFS patients, compared to 20 age-matched healthy men. Main outcomes were methylation pattern

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Ruksiriwanich, Warintorn, Chiranan Khantham, Anurak Muangsanguan, et al. "Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities." Plants 11, no. 24 (2022): 3514. http://dx.doi.org/10.3390/plants11243514.

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Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia (AGA) is chronic hair loss caused by effects of androgens in those with a genetic predisposition, resulting in hair follicle miniaturization. Our objectives were to provide the mechanistic assessment of guava leaf extract on gene expressions related to the androgen pathway in well-known in vitro models, hair follicle dermal papilla cells (HFDPC), and human prostate cancer cells (DU-145), and to determine its bioactive cons

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Cortés-Pavía, Iván, Abel Moreno-Cárcamo, Abraham Landa-Piedra, and Marisa Cabeza. "Largo trabajo y mucho que resolver aún sobre las isoenzimas de la 5-alfa reductasa Revisión bibliográfica." Latin American Journal of Development 6, no. 2 (2024): e2358. http://dx.doi.org/10.46814/lajdv6n2-009.

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Este trabajo revisa los principales artículos relacionados con la actividad de la enzima 5α-reductasa (SRD5A) y las patologías andrógeno-dependientes como la hiperplasia prostática benigna, el cáncer de próstata, acné y la calvicie androgénica entre otras. Con este propósito, se revisaron diferentes plataformas como Medline, Scopus y Science Direct, utilizando como indicadores las palabras 5α-reductasa, isoenzimas y patologías andrógeno- dependientes. Con esta clasificación se encontraron artículos clásicos de décadas anteriores y nuevos artículos en donde aparece ya descrita, la estructura de

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Lassche, Gerben, Yuichiro Tada, Carla M. L. van Herpen, et al. "Predictive and Prognostic Biomarker Identification in a Large Cohort of Androgen Receptor-Positive Salivary Duct Carcinoma Patients Scheduled for Combined Androgen Blockade." Cancers 13, no. 14 (2021): 3527. http://dx.doi.org/10.3390/cancers13143527.

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Patients suffering from recurrent or metastatic (R/M) salivary duct carcinoma (SDC) are often treated with combined androgen blockade (CAB). However, CAB frequently fails, resulting in a worse prognosis. Therefore, biomarkers that can predict treatment failure are urgently needed. mRNA from 76 R/M androgen receptor (AR)-positive SDC patients treated with leuprorelin acetate combined with bicalutamide was extracted from pre-treatment tumor specimens. AR, Notch, MAPK, TGFβ, estrogen receptor (ER), Hedgehog (HH), and PI3K signaling pathway activity scores (PAS) were determined based on the expres

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Wako, K., T. Kawasaki, K. Yamana, et al. "Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer." Journal of Clinical Pathology 61, no. 4 (2007): 448–54. http://dx.doi.org/10.1136/jcp.2007.050906.

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Aims:The association between the expression of androgen receptor (AR) or androgen-converting enzymes and malignant potential in prostate cancer (PCa) was examined.Methods:PCa specimens from 44 cases of stage II, 10 cases of stage III, four cases of stage IV and two recurrent cases were semi-quantitatively studied with immunohistochemistry for AR and androgen-converting enzymes.Results:The expression scores for AR, 5α-reductase type 1 (SRD5A1), 5α-reductase type 2 (SRD5A2), and aldo-keto reductase family 1 member C3 (AKR1C3) in the metastatic lesion of stage IV or recurrent cancer (n = 6) were

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Lassche, Gerben, Yuichiro Tada, Carla M. L. Van Herpen, et al. "Predictive and prognostic biomarker identification in a large cohort of androgen receptor-positive salivary duct carcinoma patients scheduled for combined androgen blockade." Journal of Clinical Oncology 39, no. 15_suppl (2021): 6071. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.6071.

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6071 Background: Patients suffering from recurrent or metastatic (R/M) salivary duct carcinoma (SDC) are often treated with combined androgen blockade (CAB). This treatment however frequently fails (response rates: 18-53%), resulting in a worse prognosis. Therefore, biomarkers that have prognostic value and can predict treatment response are urgently needed. Methods: mRNA from 77 R/M androgen receptor (AR) positive SDC patients treated with leuprorelin acetate combined with bicalutamide was extracted from pre-treatment tumor specimens. AR, Notch, Mitogen-Activated Protein Kinase (MAPK), Transf

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Bamodu, Oluwaseun Adebayo, Kai-Yi Tzou, Chia-Da Lin, et al. "Differential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer." Cancers 13, no. 14 (2021): 3478. http://dx.doi.org/10.3390/cancers13143478.

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Background: Testosterone plays a critical role in prostate development and pathology. However, the impact of the molecular interplay between testosterone-associated genes on therapy response and susceptibility to disease relapse in PCa patients remains underexplored. Objective: This study investigated the role of dysregulated or aberrantly expressed testosterone-associated genes in the enhanced dissemination, phenoconversion, and therapy response of treatment-resistant advanced or recurrent PCa. Methods: Employing a combination of multi-omics big data analyses, in vitro, ex vivo, and in vivo a

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Muangsanguan, Anurak, Warintorn Ruksiriwanich, Chaiwat Arjin, et al. "Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza sativa L. cv. Buebang 3 CMU and Sanpatong." Plants 13, no. 21 (2024): 3079. http://dx.doi.org/10.3390/plants13213079.

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The bioactive compounds in herbal extracts may provide effective hair loss treatments with fewer side effects compared to synthetic medicines. This study evaluated the effects of Buebang 3 CMU and Sanpatong rice bran extracts, macerated with dichloromethane or 95% ethanol, on hair growth promotion and hair loss prevention. Overall, Buebang 3 CMU extracts contained significantly higher levels of bioactive compounds, including γ-oryzanol, tocopherols, and various polyphenols such as phytic acid, ferulic acid, and chlorogenic acid, compared to Sanpatong extracts. Additionally, ethanolic extracts

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Valenzuela Scheker, Evana, Amita Kathuria, Ashwini Esnakula, et al. "Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified." Journal of Investigative Medicine High Impact Case Reports 8 (January 2020): 232470962093341. http://dx.doi.org/10.1177/2324709620933416.

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To characterize the expression of steroidogenic enzymes implicated in the development of ovarian steroid cell tumors, not otherwise specified (SCT-NOS). We present 4 ovarian SCT-NOS evaluated by immunohistochemical staining of steroidogenic enzymes as an approach to define this entity pathologically. All 4 ovarian SCT-NOS showed increased expression for cholesterol side-chain cleavage enzyme (CYP11A1), 17α-hydroxylase (CYP17A1), 17β-hydroxysteroid dehydrogenase 1 (HSD17B1), aldo-ketoreductase type 1 C3 (AKR1C3), 3β-hydroxysteroid dehydrogenase 2 (HSD3B2), 5α-reductase type 2 (SRD5A2), steroid

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Fischer, Alexandra, Sonja Gaedicke, Jan Frank, Frank Döring, and Gerald Rimbach. "Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver." British Journal of Nutrition 104, no. 7 (2010): 935–40. http://dx.doi.org/10.1017/s0007114510001649.

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The aim of the present study was to determine the effects of a 6-month dietary vitamin E (VE) deficiency on DNA methylation and gene expression in rat liver. Two enzymes, 5-α-steroid reductase type 1 (SRD5A1) and the regulatory subunit of γ-glutamylcysteinyl synthetase (GCLM), which are differentially expressed on the mRNA level, were analysed for promoter methylation in putative cytosine-phospho-guanine (CpG) island regions located at the 5′ end using base-specific cleavage and matrix-assisted laser desorption ionisation time-of-flight MS. A twofold increase in the mRNA level of SRD5A1 gene a

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Muangsanguan, Anurak, Pichchapa Linsaenkart, Tanakarn Chaitep, et al. "Hair Growth Promotion and Anti-Hair Loss Effects of By-Products Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction." Foods 12, no. 22 (2023): 4116. http://dx.doi.org/10.3390/foods12224116.

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Coffee has been a common ingredient in many traditional hair loss remedies, but limited scientific evidence supports its use, particularly in coffee pulp. Androgenetic alopecia (AGA) is caused by androgens, inflammation, and oxidative stress. In the present study, supercritical fluid extraction (SFE) was used under various conditions to obtain six coffee pulp extracts. The SFE-4 extract, using 50% (v/v) ethanol as a co-solvent at conditions of 100 °C and 500 bars for 30 min, exhibited the highest phenolic, flavonoid, and caffeine contents. Additionally, the SFE-4 extract increased the migratio

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Caglayan, A. Okay, Munis Dundar, Fatih Tanriverdi та ін. "Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2)". Fertility and Sterility 96, № 2 (2011): 479–82. http://dx.doi.org/10.1016/j.fertnstert.2011.05.040.

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Zhou, Zhifeng, and Phyllis W. Speiser. "Regulation of HSD17B1 and SRD5A1 in Lymphocytes." Molecular Genetics and Metabolism 68, no. 3 (1999): 410–17. http://dx.doi.org/10.1006/mgme.1999.2898.

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Applegate, Catherine, Matthew Lowerison, Emma Hambley, Pengfei Song, and John Erdman. "Dietary Tomato Inhibits Tumor Angiogenesis in the TRAMP Model of Prostate Cancer but Is Not Protective With a Western-Style Diet." Current Developments in Nutrition 5, Supplement_2 (2021): 260. http://dx.doi.org/10.1093/cdn/nzab036_002.

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Abstract Objectives The objective of this study was to investigate the interplay between tomato powder (TP), incorporated into control (CON) and obesogenic (OB) diets, and PCa tumor growth and blood perfusion over time in a transgenic model of PCa. We hypothesized that TP would be protective against PCa growth. Methods Diets (either CON [17.2% kcal from fat] or OB [44.6% kcal from fat] both with and without 10% TP) were fed to transgenic adenocarcinoma of the mouse prostate (TRAMP) mice (n = 5/dietary group) from weaning. Tumor growth was monitored by weekly ultrasound scanning, at which time

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Klotsman, M., C. R. Weinberg, K. Davis, C. G. Binnie, and K. E. Hartmann. "A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH." Pharmacogenomics Journal 4, no. 4 (2004): 251–59. http://dx.doi.org/10.1038/sj.tpj.6500248.

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Barnard, Lise, Nikolaos Nikolaou, Carla Louw, et al. "The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1." Journal of Steroid Biochemistry and Molecular Biology 202 (September 2020): 105724. http://dx.doi.org/10.1016/j.jsbmb.2020.105724.

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Mitsiades, N., N. Schultz, B. S. Taylor, et al. "Increased expression of androgen receptor (AR) and enzymes involved in androgen synthesis in metastatic prostate cancer: Targets for novel personalized therapies." Journal of Clinical Oncology 27, no. 15_suppl (2009): 5002. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.5002.

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5002 Background: Androgen receptor (AR) signaling remains active in castration-resistant prostate cancer (CRPC) despite castrate levels of circulating androgens. This is indicated by continuous expression of androgen-responsive genes and is due to mechanisms that include: increased AR expression; AR mutations allowing promiscuous activation by alternative ligands; and increased intratumoral androgen levels, resulting from in situ steroidogenesis. Methods: Gene expression profiles of 30 normal prostate tissue samples, 131 primary prostate carcinomas (PCas) and 16 metastatic PCas, generated usin

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Cabeza, Marisa, Luis A. Menes, Evelyn Fuentes, Iván Bahena, and Yvonne Heuze. "Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells." Oriental Journal Of Chemistry 39, no. 3 (2023): 523–32. http://dx.doi.org/10.13005/ojc/390301.

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This study demonstrated the antiproliferative potential of several dehydroepiandrosterone derivatives 2a-b, 3a-f, and 4a-f in LNCaP cells. LNCaP cells were cultured in the presence of the vehicle, dihydrotestosterone, or testosterone plus 2a-b, 3a-f, 4a-f, or finasteride. At 24 h the 3-(4,5-dimethylthiazol-2-yl)-2,5-di phenyltetrazolium bromide-test was performed to determine cell proliferation. In addition, the kinetic of SRD5A1 in these cells was studied in the presence or absence of different concentrations of 2a. Testosterone and dihydrotestosterone increased the proliferation of LNCaP com

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Ruksiriwanich, Warintorn, Chiranan Khantham, Anurak Muangsanguan, et al. "Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract." Plants 11, no. 11 (2022): 1499. http://dx.doi.org/10.3390/plants11111499.

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In Thai folklore wisdom, shallot (Allium ascalonicum L.) was applied as a traditional herbal medicine for hair growth promotion with no scientific evidence. Androgenetic alopecia (AGA) is a progressive hair loss caused by multiple factors, including androgen hormones, inflammation, and oxidative stress. Conventional medicines (finasteride, dutasteride, corticosteroids, and minoxidil) have been used with limited therapeutic efficacy and unpleasant side effects. In this study, we aimed to give the first estimation of bioactive compounds in shallot extract and evaluate the hair growth-promoting a

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Ramos, Luis, Bertha Chávez та Felipe Vilchis. "Cloning and differential expression of steroid 5α-reductase type 1 (Srd5a1) and type 2 (Srd5a2) from the Harderian glands of hamsters". General and Comparative Endocrinology 166, № 2 (2010): 388–95. http://dx.doi.org/10.1016/j.ygcen.2009.12.010.

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Graupp, M., E. Wehr, N. Schweighofer, T. R. Pieber та B. Obermayer-Pietsch. "Association of genetic variants in the two isoforms of 5α-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome". European Journal of Obstetrics & Gynecology and Reproductive Biology 157, № 2 (2011): 175–79. http://dx.doi.org/10.1016/j.ejogrb.2011.03.026.

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Barresi, Vincenza, Salvatore S. Signorelli, Nicolò Musso, et al. "ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease." Vascular Medicine 19, no. 3 (2014): 175–81. http://dx.doi.org/10.1177/1358863x14532705.

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Taheri, Serpil, Gokmen Zararsiz, Sulbiye Karaburgu, et al. "Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH." European Journal of Endocrinology 173, no. 4 (2015): 447–54. http://dx.doi.org/10.1530/eje-15-0460.

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ObjectiveHirsutism results from hyperandrogenemia and/or exaggerated androgen responsiveness. Among various causes of hirsutism, some patients do not exhibit androgen excess which is called idiopathic hirsutism (IH). The pathogenesis of IH could not so far be clearly established.DesignTo investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumbilical skin and the arm of the patients with IH and healthy women.MethodsTwenty-one women with IH and 15 healthy women were included in the

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Rył, Aleksandra, Iwona Rotter, Anna Grzywacz, et al. "Molecular Analysis of the SRD5A1 and SRD5A2 Genes in Patients with Benign Prostatic Hyperplasia with Regard to Metabolic Parameters and Selected Hormone Levels." International Journal of Environmental Research and Public Health 14, no. 11 (2017): 1318. http://dx.doi.org/10.3390/ijerph14111318.

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Gu, Xin, Rong Na, Tao Huang та ін. "SRD5A1 and SRD5A2 are Associated with Treatment for Benign Prostatic Hyperplasia with the Combination of 5α-Reductase Inhibitors and α-Adrenergic Receptor Antagonists". Journal of Urology 190, № 2 (2013): 615–19. http://dx.doi.org/10.1016/j.juro.2013.03.024.

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Nadeem, Amna, Lubna Nadeem, Stephen James Lye, and Oksana Shynlova. "Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice." Cells 14, no. 4 (2025): 242. https://doi.org/10.3390/cells14040242.

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In most mammals, a withdrawal of the pro-gestational hormone progesterone (P4) is necessary for labor onset. In murine cervix, P4 withdrawal is mediated by enzymes steroid 5-alpha-reductase type 1 (SRD5A1) and 20-alpha-hydroxysteroid-dehydrogenase (20α-HSD). Previously, we have shown that inflammatory stimuli induce 20α-HSD levels in uterine muscle (myometrium). Here, we hypothesized that (1) infectious inflammation alters the levels of both P4-metabolizing enzymes in mouse cervix, which consequently ceases P4-mediated inhibition of cervical remodeling, thereby inducing preterm labor (PTL); (2

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Adams, Marlene, and Susan McCrone. "SRD5A1 Genotype Frequency Differences in Women with Mild versus Severe Premenstrual Symptoms." Issues in Mental Health Nursing 33, no. 2 (2012): 101–8. http://dx.doi.org/10.3109/01612840.2011.625514.

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Wu, X. W., K.-F. P. Chiu, and C.-F. Ng. "Mechanism of IL-6/STAT3 regulation of SRD5A1 in prostate cancer cells." European Urology Open Science 57 (November 2023): S380. http://dx.doi.org/10.1016/s2666-1683(23)01570-7.

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Ha, Mei, Pei Zhang, Lianbing Li, and Changjiang Liu. "Triclosan Suppresses Testicular Steroidogenesis via the miR-6321/JNK/ Nur77 Cascade." Cellular Physiology and Biochemistry 50, no. 6 (2018): 2029–45. http://dx.doi.org/10.1159/000495049.

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Background/Aims: Triclosan (TCS), a broad-spectrum antibacterial and antifungal compound and an endocrine disruptor, has anti-androgenic properties and could adversely affect male reproduction and fertility. Methods: To elucidate the underlying roles of miRNAs and the MAPK pathway in TCS-mediated repression of testicular steroidogenesis, Sprague-Dawley male rats were dosed daily with TCS for 31 days, and TM3 cells were exposed to TCS for 24 h after the pretreatments with the activator of JNK, Nur77 siRNA, or recombinant lentivirus vector for Nur77. Tissues and/or cells were analyzed by several

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El-Sheikh Ali, H., E. L. Legacki, K. E. Scoggin, et al. "Steroid synthesis and metabolism in the equine placenta during placentitis." Reproduction 159, no. 3 (2020): 289–302. http://dx.doi.org/10.1530/rep-19-0420.

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Equine placentitis is associated with alterations in maternal peripheral steroid concentrations, which could negatively affect pregnancy outcome. This study aimed to elucidate the molecular mechanisms related to steroidogenesis and steroid-receptor signaling in the equine placenta during acute placentitis. Chorioallantois (CA) and endometrial (EN) samples were collected from mares with experimentally induced placentitis (n = 4) and un-inoculated gestationally age-matched mares (control group; n = 4). The mRNA expression of genes coding for steroidogenic enzymes (3βHSD, CYP11A1, CYP17A1, CYP19A

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Hazra, Rasmani, Mark Jimenez, Reena Desai, David J. Handelsman, and Charles M. Allan. "Sertoli Cell Androgen Receptor Expression Regulates Temporal Fetal and Adult Leydig Cell Differentiation, Function, and Population Size." Endocrinology 154, no. 9 (2013): 3410–22. http://dx.doi.org/10.1210/en.2012-2273.

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We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor expression (TgSCAR). Here we reveal that TgSCAR regulates the development, function, and absolute number of Leydig cells (LCs). Total fetal and adult type LC numbers were reduced in postnatal and adult TgSCAR vs control testes, despite normal circulating LH levels. Normal LC to SC ratios found in TgSCAR testes indicate that SC androgen receptor (SCAR)-mediated activity confers a quorum-dependent relationship between total SC and LC numbers.

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Liu, Xue, Dandan Wei, Jingjing Jiang, et al. "Associations of SRD5A1 gene variants and testosterone with dysglycemia: Henan Rural Cohort study." Nutrition, Metabolism and Cardiovascular Diseases 30, no. 4 (2020): 599–607. http://dx.doi.org/10.1016/j.numecd.2019.11.011.

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Lemus, Ana E., Juana Enríquez, Ángeles Hernández, René Santillán, and Gregorio Pérez-Palacios. "Bioconversion of norethisterone, a progesterone receptor agonist into estrogen receptor agonists in osteoblastic cells." Journal of Endocrinology 200, no. 2 (2008): 199–206. http://dx.doi.org/10.1677/joe-08-0166.

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A number of clinical studies have demonstrated that norethisterone (NET), a potent synthetic progestin, restores postmenopausal bone loss, although its mode of action on bone cells is not fully understood, while the effect of naturally occurring progesterone in bone has remained controversial. A recent report claims that the potent effects of NET on osteoblastic cell proliferation and differentiation, mimicking the action of estrogens, are mediated by non-phenolic NET derivatives. To determine whether osteoblasts possess the enzymes required to bioconvert a progesterone receptor (PR) agonist i

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Gu, X., R. Na, W. Li та ін. "901 SRD5A1 and SRD5A2 genes are associated with the treatment for benign prostatic hyperplasia with the combination of 5α-reductase inhibitors and α-adrenergic-receptor antagonist". European Urology Supplements 12, № 1 (2013): e901. http://dx.doi.org/10.1016/s1569-9056(13)61380-9.

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Miao, Zhuo, Min Sun, Feng Jiang, Yuanqing Yao, and Yi Li. "Negative Effects of SRD5A1 on Nuclear Activity of Progesterone Receptor Isoform B in JEG3 Cells." Reproductive Sciences 23, no. 2 (2015): 192–99. http://dx.doi.org/10.1177/1933719115597764.

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Eminović, Izet, Mirjana Liović, Janez Preželj, Andreja Kocijančič, Damjana Rozman та Radovan Komel. "New steroid 5Α-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8". Pfl?gers Archiv European Journal of Physiology 442, № 7 (2001): r187—r189. http://dx.doi.org/10.1007/s004240100019.

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Martin, C. S., M. Singh Kalirai, A. Crastin, et al. "POS0056 GLOBAL STEROID METABOLISM IN MACROPHAGES: SHAPING INFLAMMATORY FUNCTION AND DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 244.3–244. http://dx.doi.org/10.1136/annrheumdis-2022-eular.782.

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BackgroundMacrophages are key drivers of joint destruction and disease pathophysiology in rheumatoid arthritis (RA), where their inflammatory function is influenced by steroid hormones such as androgens and glucocorticoids (GCs). Local bioavailability of these steroids is determined by both systemic adrenal/gonadal synthesis and local metabolism in peripheral target tissues. The inflammatory regulation and function of steroid hormone metabolism by key rate limiting enzymes in chronic inflammatory diseases such as RA remain poorly defined and could present new therapeutic targets.ObjectivesChar

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Coppens, Grégoire, Ilse Vanhorebeek, Fabian Güiza, et al. "Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness." Clinical Epigenetics 16, no. 1 (2024): 31. https://doi.org/10.1186/s13148-024-01640-y.

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<strong>Background: </strong>Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may impair normal brain development, cognition and behaviour. We tested the hypothesis that paediatric-intensive-care-unit (PICU) patients, sex- and age-dependently, show long-term abnormal DNA methylation within the HPA-axis layers, possibly aggravated by glucocorticoid treatment in the PICU, which may contribute to the long-term developmental impairments.<strong>R

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Signorelli, S. S., V. Barresi, N. Musso та ін. "Polymorphisms of steroid 5- α- reductase type I (SRD5A1) gene are associated to peripheral arterial disease". Journal of Endocrinological Investigation 31, № 12 (2008): 1092–97. http://dx.doi.org/10.1007/bf03345658.

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Redler, Silke, Rachid Tazi-Ahnini, Dmitriy Drichel, et al. "Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified." Experimental Dermatology 21, no. 5 (2012): 390–93. http://dx.doi.org/10.1111/j.1600-0625.2012.01469.x.

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Ogawa, Kazushige, and Takashi Tanida. "Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules." Biomedicines 11, no. 3 (2023): 985. http://dx.doi.org/10.3390/biomedicines11030985.

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Tissue-resident macrophages (Mø) play tissue/organ-specific roles, and the physiological/pathological implications of uterine Mø in fertility and infertility are not yet fully understood. Herein, we report a simple propagation method for tissue-resident Mø by mixed culture with the respective tissue/organ-residing cells as the niche. We successfully propagated mouse uterine Mø by mixed culture with fibroblastic cells that exhibited properties of endometrial stromal cells. Propagated mouse uterine Mø were CD206- and arginase-1-positive; iNOS- and MHC-II-negative, indicating M2 polarization; and

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Sinreih, Maša, Maja Anko, Sven Zukunft, Jerzy Adamski, and Tea Lanišnik Rižner. "Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines." Chemico-Biological Interactions 234 (June 2015): 297–308. http://dx.doi.org/10.1016/j.cbi.2014.11.012.

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Wu, X. W., K.-F. P. Chiu, and C.-F. Ng. "Effect of obesity-associated inflammatory factor IL-6 on the vitality of prostate cancer cells via SRD5A1." European Urology Open Science 57 (November 2023): S379. http://dx.doi.org/10.1016/s2666-1683(23)01569-0.

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Reiter, M., M. W. Pfaffl, M. Schönfelder, and H. H. D. Meyer. "Gene Expression in Hair Follicle Dermal Papilla Cells after Treatment with Stanozolol." Biomarker Insights 4 (December 23, 2008): BMI.S1173. http://dx.doi.org/10.4137/bmi.s1173.

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Doping with anabolic agents is a topic in sports where strength is crucial, e.g. sprinting, weight lifting and many more. Testosterone and its functional analogs are the drugs of choice taken as pills, creams, tape or injections to increase muscle mass and body performance, and to reduce body fat. Stanozolol (17β-hydroxy-17α-methyl-5α-androst-2-eno[3,2c]pyrazol) is a testosterone analogue with the same anabolic effect like testosterone but its ring structure makes it possible to take it orally. Therefore, stanozolol is one of the most frequently used anabolic steroids. Common verification meth

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