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Bibliografias temáticas / Synthesis of alkaloids

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Literatura científica selecionada sobre o tema "Synthesis of alkaloids"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 16 de fevereiro de 2022

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Artigos de revistas sobre o assunto "Synthesis of alkaloids"

1

Han, Sunkyu, Sangbin Jeon, and Joonoh Park. "Syntheses of Dimeric Securinega Alkaloids." Synlett 28, no. 18 (2017): 2353–59. http://dx.doi.org/10.1055/s-0036-1590864.

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The isolation of flueggenines A and B by Yue and co-workers in 2006 has triggered a burst of isolation reports of dimeric and oligomeric securinega alkaloid natural products. The compelling molecular structures of these compounds with various modes of connection between monomeric securinega units have posed intriguing challenges to the synthetic organic community. Herein, we have categorized high-order securinega alkaloids based on their biosynthetic mode of dimerization or oligomerization. We then have compiled all reported syntheses of dimeric securinega alkaloids based on our classification

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2

Lim, Hyeonggeun, Sikwang Seong, and Sunkyu Han. "Syntheses of Post-Iboga Alkaloids." Synthesis 51, no. 14 (2019): 2737–58. http://dx.doi.org/10.1055/s-0037-1612061.

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Post-iboga alkaloids are secondary metabolites that are biosynthetically derived from iboga-type alkaloids via rearrangements of the indole and/or isoquinuclidine moieties. Herein, we categorize post-iboga alkaloids into five types based on the biosynthetic mode of transformation of the iboga scaffold. We then describe reported syntheses of post-iboga alkaloids, including our laboratory’s recent contributions, based on our own categorization.1 Introduction1.1 Iboga and Post-Iboga Alkaloids1.2 Classification of Post-Iboga Alkaloids1.2.1 Introduction to Type I Post-Iboga Alkaloids1.2.2 Introduct

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3

Saha, Mrinmoy, and Rich Carter. "Lycopodium Alkaloids: An Intramolecular Michael Reaction Approach." Synlett 28, no. 17 (2017): 2212–29. http://dx.doi.org/10.1055/s-0036-1588851.

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The Lycopodium alkaloids possess a rich history that has captured the attention of synthetic chemists across the globe. This large family consists of over 250 known natural products with diverse structural features and noteworthy biological activity. Herein, we interweave the synthetic accomplishments by others in the field with our own unified strategy to accessing multiple subfamilies of the Lycopodium alkaloids. This discussion includes lycopodine, the C10-hydroxy Lycopodium alkaloids (10-hydroxylycopodine, deacetylpaniculine and paniculine), pelletierine, cermizine D, fastigiatine, himerad

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Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart

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5

Giannis, Athanassios, Farnoush Mousavizadeh, and Daniel Meyer. "Synthesis of C-Nor-D-homo-steroidal Alkaloids and Their Derivatives." Synthesis 50, no. 08 (2018): 1587–600. http://dx.doi.org/10.1055/s-0036-1591965.

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The C-nor-D-homo-steroidal alkaloid cyclopamine was discovered in the 1969 and in 2000 it was shown to act as an inhibitor of the hedgehog signaling (Hh) pathway, which is aberrantly activated in some tumors. Subsequently it was revealed that this natural occurring alkaloid has also antidiabetic and antiviral properties. In this review we present syntheses of selected C-nor-D-homo-steroidal alkaloids and their analogues and also discuss a general access to C-nor-D-homo-steroids. Some historical as well as biomedical aspects are also presented.1 Introduction2 Total Synthesis of Cyclopamine2.1 S

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6

D’hooghe, Matthias, Hyun-Joon Ha, and Lingamurthy Macha. "Deployment of Aziridines for the Synthesis of Alkaloids and Their Derivatives." Synthesis 51, no. 07 (2019): 1491–515. http://dx.doi.org/10.1055/s-0037-1611715.

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Various (activated and non-activated) aziridines with diverse substitution patterns have been deployed successfully as starting materials for the synthesis of a wide variety of alkaloids via suitable functionalization and aziridine ring transformation. Alternatively, the preparation and interception of reactive aziridine intermediates has also been shown to constitute a valid approach toward alkaloid synthesis. This review summarizes aziridine-mediated syntheses of alkaloids, in which the aziridine is mobilized as either a substrate or an advanced synthetic intermediate.1 Introduction2 Alkaloi

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7

Wink, Michael, and Ludger Witte. "Cell-Free Synthesis of the Alkaloids Ammodendrine and Smipine." Zeitschrift für Naturforschung C 42, no. 3 (1987): 197–204. http://dx.doi.org/10.1515/znc-1987-0304.

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The bipiperidyl alkaloid ammodendrine was detected in 28 plant species as a minor alkaloid besides quinolizidine alkaloids. Cadaverine serves as a precursor for both quinolizidine alkaloids and for ammodendrine, since labelled cadaverine is incorporated into both rings of ammodendrine. Cell-free extracts of Lupinus arboreus and of Pisum sativum, which contain an active diamine oxidase form ammodendrine from cadaverine and pyruvate. In addition to ammodendrine other alkaloids such as smipine, tetrahydroanabasine and tripiperideine could be detected. Possible reaction schemes are discussed.

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8

Estévez, Juan C., M. Carmen Villaverde, Ramon J. Estévez, Julio A. Seuas, and Luis Castedo. "New total synthesis of phenanthrene alkaloids." Canadian Journal of Chemistry 68, no. 6 (1990): 964–68. http://dx.doi.org/10.1139/v90-151.

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We describe a new synthesis of phenanthrene alkaloids based on the photocyclization of stilbene compounds prepared by a simple, efficient new method. It allows the preparation of phenanthrene compounds with a primary amine group in their side chain. Keywords: alkaloid, phenanthrene, stilbene, photocyclization.

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9

Li, Yong, Jian Li, Hanfeng Ding, and Ang Li. "Recent advances on the total synthesis of alkaloids in mainland China." National Science Review 4, no. 3 (2017): 397–425. http://dx.doi.org/10.1093/nsr/nwx050.

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AbstractAlkaloids are a large family of natural products that mostly contain basic nitrogen atoms. Because of their intriguing structures and important functions, they have long been popular targets for synthetic organic chemists. China's chemists have made significant progress in the area of alkaloid synthesis over past decades. In this article, selected total syntheses of alkaloids from research groups in mainland China during the period 2011–16 are highlighted.

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10

Miyashita, Masaaki. "Recent progress in the synthesis of bioactive polycyclic natural products." Pure and Applied Chemistry 79, no. 4 (2007): 651–65. http://dx.doi.org/10.1351/pac200779040651.

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The zoanthamine alkaloids, a type of heptacyclic marine alkaloid isolated from colonial zoanthids of the genus Zoanthus sp., have distinctive biological and pharmacological properties as well as their unique chemical structures with stereochemical complexity. Namely, norzoanthamine can suppress the loss of bone weight and strength in ovariectomized mice and has been considered a promising candidate for an antiosteoporotic drug, whereas zoanthamine has exhibited potent inhibitory activity toward phorbol myristate-induced inflammation in addition to powerful analgesic effects. Recently, norzoant

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Mais fontes

Teses / dissertações sobre o assunto "Synthesis of alkaloids"

1

Witt, Anette. "Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-077-6/.

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2

Kalusa, Andrew. "Synthesis of marine alkaloids." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275274.

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3

Goddard, Euan. "Asymmetric Synthesis of Alkaloids." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489446.

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4

Smith, Catherine Janet. "Synthesis of histrionicotoxin alkaloids." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620245.

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5

Choi, Joong-Kwon. "Synthesis of pyrrolizidine alkaloids /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259125219504.

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6

Brock, Elizabeth Anne. "Alkaloids from transannular iodoaminations." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:0feddc99-0fde-4dcd-b717-b0c6b0515615.

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This thesis is concerned with the development of transannular iodoamination methodology for the synthesis of pyrrolizidine, indolizidine and tropane alkaloids. Chapter 1 introduces the concept of a ‘transannular cyclisation’ and outlines the utility of such cyclisations in the synthesis of a range of [x.y.z]-azabicyclic alkaloids. Chapter 2 describes the development of a three step lithium amide conjugate addition, ring-closing metathesis and transannular iodoamination protocol for the preparation of the pyrrolizidine scaffold ([3.3.0]-azabicycle). Cyclisation of a hexahydroazocine occurs with

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7

Callaghan, Owen. "Synthetic and mechanistic studies in free radical." Thesis, University of Strathclyde, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366957.

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8

Shah, Rushabh Surendra. "Total syntheses of the nakinadine alkaloids." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c022e538-9ff8-4914-8c17-dc0b3ed1fbae.

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This thesis is concerned with the development of methodology for the asymmetric syntheses of the nakinadine family of marine alkaloids and through these synthetic endeavours, seeks to confirm the structure and assign the relative and absolute configurations of these alkaloids for the first time.

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9

Antropow, Alyssa Hope. "Synthesis and anticancer evaluation of agelastatin alkaloid derivatives and enantioselective total synthesis of aspidosperma alkaloids." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118214.

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Thesis: Ph. D. in Organic Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>I. Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis The synthesis of new agelastatin alkaloid derivatives and their anticancer evaluation in the context of the breast cancer microenvironment is described. A variety of Ni -alkyl and C5-ether agelastatin derivatives were accessed via application of our strategy for convergent imidazolone synthe

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10

Bosch, Caroline. "Total Synthesis of Phlegmarine Alkaloids." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399380.

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This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists first in the development of an easy procedure to access enantiopure substituted octahydroindoles relevant for natural products synthesis, then in the diversification of a common building block used for the total synthesis of phlegmarine alkaloids allowing access to unprecedented heterocyclic tetrahydrocarbazoles compounds, but most importantly in the achievement of a methodology

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Mais fontes

Livros sobre o assunto "Synthesis of alkaloids"

1

Alkaloid synthesis. Springer, 2012.

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2

Matsuoka, Junpei. Total Synthesis of Indole Alkaloids. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8652-1.

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3

Mo, Ruowei. Towards the enantioselective synthesis of lycoricidine alkaloids. Brock University, Dept. of Chemistry, 1998.

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4

Greer, Robert James. Studies in the synthesis of quinoline alkaloids. The Author), 1987.

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5

Neville, Charles Frederick. The synthesis and biosynthesis of quinoline alkaloids. The Author], 1989.

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6

Jameson, Simon Brent. Approaches to chiral synthesis of cyclopentanoids and alkaloids. University of Manchester, 1994.

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7

Tirkkonen, Birgit. Stereoselective syntheses in the corynantheine series and of related model compounds. Suomalainen Tiedeakatemia, 1994.

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8

Tian ran chan wu quan he cheng hui cui: Sheng wu jian = Hightlights of total synthesis of natural products : alkaloids. Ke xue chu ban she, 2009.

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9

Bond, Timothy J. Approaches towards the synthesis of naturally occurring toxic alkaloids. typescript, 1995.

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10

Cinchona alkaloids in synthesis and catalysis: Ligands, immobilization and organocatalysis. Wiley-VCH, 2009.

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Capítulos de livros sobre o assunto "Synthesis of alkaloids"

1

Wink, Michael, and Margaret F. Roberts. "Compartmentation of Alkaloid Synthesis, Transport, and Storage." In Alkaloids. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4757-2905-4_10.

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2

Rinner, Uwe, and Mario Waser. "Tyrosine Alkaloids." In From Biosynthesis to Total Synthesis. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118754085.ch12.

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3

Michel, Sylvie, and François Tillequin. "Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Indolemonoterpene Alkaloids." In Biomimetic Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634606.ch3.

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4

Welch, Timothy R., and Robert M. Williams. "Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Dioxopiperazine Alkaloids." In Biomimetic Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634606.ch4.

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5

Duval, Romain, and Erwan Poupon. "Biomimetic Synthesis of Manzamine Alkaloids." In Biomimetic Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634606.ch6.

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6

Brauch, Sebastian, Wouter S. Veldmate, and Floris P. J. T. Rutjes. "Ornithine and Lysine Alkaloids." In From Biosynthesis to Total Synthesis. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118754085.ch11.

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7

Tang, Zhen-Yu. "Anthranilic Acid-Tryptophan Alkaloids." In From Biosynthesis to Total Synthesis. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118754085.ch14.

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8

Movassaghi, Mohammad, and Sunkyu Han. "Total Synthesis of All (-)-Agelastatin Alkaloids." In Asymmetric Synthesis II. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527652235.ch49.

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9

Kutney, J. P. "The Synthesis of Indole Alkaloids." In Total Synthesis of Natural Products. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470129661.ch2.

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10

Pyne, Michael E., Lauren Narcross, Cecilie I. C. Hansen, et al. "Microbial Synthesis of Plant Alkaloids." In Biotechnology of Natural Products. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67903-7_5.

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Trabalhos de conferências sobre o assunto "Synthesis of alkaloids"

1

Wipf, Peter, and Filip Petronijevic. "New Approaches to Indoles and Indole Alkaloids." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0388-1.

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2

Trauner, Dirk, Johann Mulzer, Jan Bats, Stefanie Porth, and Till Opatz. "Total Synthesis of Morphine- and Hasubanane Alkaloids." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02045.

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3

Sarpong, Richmond. "Strategies and Tactics for Synthesis Inspired by Complex Alkaloids." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-speech7.

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4

Bertonha, Ariane F., and Antonio C. B. Burtoloso*. "Studies aiming the synthesis of the indolizidine alkaloids (+)-Ipalbidine and (+)-Antofine." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201391415130.

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5

Pinho, Vagner D., and Antonio C. B. Burtoloso. "Diversity synthesis of indolizidine alkaloids from a,b- unsaturated diazoketones by the Wolff rearrangement." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0128-1.

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6

Wendler, Edison P., Rafaela C. Carmona, and Alcindo A. Dos Santos. "A3 Coupling Reaction as a Key Strategy in a Three-Step Synthesis of Bioactive Alkaloids." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0205-1.

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7

HENRIQUE GONCALVES DEFANTE, LUIS, and Ronaldo Aloise Pilli. "Synthesis of a pyrrolo[1,2-a]azepino ring aiming the synthesis of Stemona alkaloids." In XXV Congresso de Iniciação Cientifica da Unicamp. Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-78501.

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8

Burtoloso, Antonio C. B. "α,β-Unsaturated Diazoketones as Useful Platforms in the Synthesis of Pyrrolidine, Piperidine and Indolizidine Alkaloids". У 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-young5.

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9

Resende, Diana, Madalena Pinto, Mariana Almeida, Paulo Costa, and Emília Sousa. "Initial steps on the synthesis of new antimicrobial fumiquinazoline related alkaloids." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07494.

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10

Ullah, Hamid, and Fernando Coelho. "A direct approach towards the preparation of intermediates to the synthesis of Amaryllidaceae alkaloids from Morita-Baylis-Hillman adducts." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0319-2.

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