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Teses / dissertações sobre o tema "Tachykinins"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

Bell, Nicola Jane. "Peripheral tachykinins and tachykinin receptors." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428305.

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2

Chambers, J. K. "Molecular forms of tachykinins." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334079.

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3

Makeham, John M. "Functional neuroanatomy of tachykinins in brainstem autonomic regulation." Connect to full text, 2006. http://hdl.handle.net/2123/1960.

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Thesis (Ph. D.)--University of Sydney, 2007.<br>Title from title screen (viewed 1 November 2007). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Physiology, Faculty of Medicine. Degree awarded 2007 ; thesis submitted 2006. Bibliography: leaves 239-284. Also issued in print.

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4

Patak, Eva Nicole. "Modulation of mammalian uterine contractility by tachykinins." Monash University, Dept. of Pharmacology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9501.

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5

Reynolds, Paul N. "The role of tachykinins in airway inflammation and bronchial hyper-responsiveness /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr464.pdf.

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6

Makeham, John Murray. "Functional neuroanatomy of tachykinins in brainstem autonomic regulation." University of Sydney, 1997. http://hdl.handle.net/2123/1960.

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Doctor of Philosophy (PhD)<br>Little is known about the role that tachykinins, such as substance P and its receptor, the neurokinin-1 receptor, play in the generation of sympathetic nerve activity and the integration within the ventrolateral medulla (VLM) of many vital autonomic reflexes such as the baroreflex, chemoreflex, somato-sympathetic reflex, and the regulation of cerebral blood flow. The studies described in this thesis investigate these autonomic functions and the role of tachykinins through physiological (response to hypercapnoea, chapter 3), anatomical (neurokinin-1 receptor immuno

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7

Kaiser, William Joseph. "Peripheral tachykinins in platelets, plasma & endocrine tissues." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542266.

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8

Jones, Sarah. "Peripheral tachykinins and the NK1 receptor regulate platelet function." Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493813.

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Tachykinins are a family of neuropeptides characterised by the conserved C-terminal motif FXGLM-NH2, where X represents a hydrophobic amino acid. Substance P (SP) a member of the tachykinin family has recently been shown to stimulate platelet aggregation and a SP-like immunoreactivity has been demonstrated in platelets and shown to be released upon platelet activation, suggesting that SP may act as a secondary platelet agonist. In recent years a gene encoding new members of the tachykinin family has been identified named TTAC4, which unlike the classical tachykinins is predominantly expressed

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9

Landis, Geoffrey Carrothers. "Synthesis and biological activities of tachykinin and opioid-related compounds, synthesis of unusual amino acids, and the investigations into the smooth muscle pharmacology of tachykinins." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184656.

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Eight cyclic analogues of Substance P were made in order to investigate the conformation of the C-terminal end of the peptide. These analogues were designed to test three literature models describing the active conformation of substance P. Although the potencies of the analogues were low (in the micromolar range), our results support Cotrait's and Hospital's model (1986). Several substance P antagonists were synthesized. These compounds did not demonstrate agonistic activity nor anatagonistic activity. The tryptophan side chain is contributing to the antagonistic activity of these analogues, a

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10

Schamber, Kristopher Cody. "Tachykinin NK3R protein levels in the PVN of rats following an osmotic challenge." Laramie, Wyo. : University of Wyoming, 2007. http://proquest.umi.com/pqdweb?did=1407489691&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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11

McLaughlin, Lynn. "The role of tachykinins in depression, mood disorders and epilepsy." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632136.

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Transgenic and knockout mouse models of disease and gene function have revolutionised the field of biomedical research and the targeted mutations of genes expressed in the brain are revealing the mechanisms underlying normal behaviour and behavioural abnormalities which has led to the development of behavioural neuroscience. However, it is also clear that the phenomena know as "redundancy" can limit the effectiveness of traditional knockout models by the effects of compensatory mechanisms. This thesis utilises transgenic and knockout mouse models to explore the role of the tachykinins in the p

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12

Graham, Gwenda Joanne. "The role of tachykinins in the regulation of platelet function." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408330.

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13

Norris, Sarah K. "Electrophysiological studies of tachykinins in the rat medial habenula nucleus." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319545.

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14

Gunnell, Andrea. "Regulation of mucin secretion from airway epithelia by proteases and tachykinins." Thesis, University of Brighton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413106.

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15

Hu, Guangfu, and 呼光富. "Novel pituitary actions of TAC3 gene products in grass carp." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208050.

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16

Chan, Wing Sai. "Roles of neurokinin receptor one in six-hydroxydopamine-lesioned rat : an animal model of Parkinson's disease." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/712.

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17

Guard, Steven. "A study of NK-3 tachykinin receptors." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:9cb9ab58-cd84-49ec-a87d-2c388064648b.

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18

Maubach, Karen Ann. "The role of tachykinins in synaptic transmission in the nucleus tractus solitarius." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306881.

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19

Stratton, Sharon Carolyne. "The effects of tachykinins in the dorsal raphe nucleus of the rat." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338540.

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20

Adetoye, Mercy A. "Regulation of photoperiodic prolactin secretion the possible roles of the pars tuberalis and tachykinins /." Laramie, Wyo. : University of Wyoming, 2009. http://proquest.umi.com/pqdweb?did=2065701641&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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21

Chu, Man Tak. "Differential effects of neurokinins in models of Parkinson's disease." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1252.

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22

Chawla, Monica Kapoor 1950. "Localization of tachykinins and their receptormRNAs in the human hypothalamus and basal forebrain." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282168.

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Numerous studies in experimental animals have emphasized the importance of tachykinin peptides in hypothalamic function. There is however, little information on the location of these peptides in the human brain. In the first study, in situ hybridization was used to map the distribution of neurons expressing the substance P (SP) or neurokinin B (NKB) gene transcripts. The distribution of neurons containing tachykinin mRNAs was found to be distinct and complementary: SP was the predominant tachykinin in the striatum, posterior hypothalamus and intermediate, ventromedial and mammillary nuclei; th

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23

Sadananda, Prajni Medical Sciences Faculty of Medicine UNSW. "Sensory and motor roles of tachykinins, vanilloids and acid in the urinary bladder mucosa." Awarded by:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/44979.

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The bladder mucosa plays an essential role in bladder function. Several receptors are expressed on mucosal cells and the mucosal release of mediators is considered to contribute to bladder afferent signalling. However, mucosal motor activity has not been previously examined. The aim of this thesis was to examine the role of vanilloid TRPV1 and tachykinin NK2 receptors in the bladder mucosa. In addition, the expression and function of novel acid sensing ion channels (ASICs) was explored. Pig and rat models were employed to examine potential species specific differences. In organ bath experimen

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24

Halliday, Dale Andrew. "The effects of tachykinins and their metabolites or articular cartilage chondrocyte and synviocyte function /." Title page, contents and introduction only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh1878.pdf.

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25

Bane, Steven Edward. "Expression and characterization of the human neurokinin 1 receptor from Escherichia coli." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 99 p, 2007. http://proquest.umi.com/pqdweb?did=1342742951&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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26

Haley, Gwendolen E. "Contribution of neurokinin 3 receptor signaling to systemic vasopressin and oxytocin release." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1594497031&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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27

Petitet, François. "Les tachykinines et leurs récepteurs centraux : étude de ligands sélectifs." Paris 5, 1988. http://www.theses.fr/1988PA05P272.

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28

Carelse, Tofa Kashefa. "Molecular genetic analysis of the neurokinin B (TAC3) and neurokinin B receptor (TAC3) genes as candidates for pre-eclampsia." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50029.

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Thesis (MSc)--Stellenbosch University, 2004.<br>ENGLISH ABSTRACT: Hypertensive conditions of pregnancy, such as pre-eclampsia, are the principal direct cause of maternal morbidity and mortality and affect up to 10% of first pregnancies worldwide. The placenta is vital in the pathogenesis of pre-eclampsia since the condition only occurs in the presence of placental tissue and the only cure is delivery of the placenta and the fetus. It has been hypothesised that the placenta may be the source of a circulating factor(s), which transports freely in the maternal system, resulting in the mult

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29

Chen, Yuejin. "Characterization of the Vasoactivity of Tachykinins in Isolated Rat Kidney: Functional Studies and in Vitro Receptor Autoradiography." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etd/2892.

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Although tachykinins have potent vascular actions, their effect on renal resistance blood vessels is currently unknown. The vasoactive properties of tachykinins and related analogs were assessed in isolated perfused rat kidney. At a basal perfusion pressure (PP) of 75 $\pm$ 6 mm Hg (n = 5), bolus injections of substance P (SP) had no significant vasoactive effect. Following a sustained increase in baseline PP (134 $\pm$ 10 mm Hg) produced by phenylephrine (1 $\mu$M), SP evoked a dose-dependent increase in PP. The largest dose of SP increased PP by 60 $\pm$ 5 mm Hg. The vasocons

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30

Parker, Rachel. "The role of tachykinins in acute nociceptive responses and in long term changes within spinal neurons during inflammation." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/29933.

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The tachykinins, substance P (SP) and neurokinin A (NKA), contained in primary afferent fibres, are thought to function as nociceptive neurotransmitters in the spinal cord. This study addressed the role of their receptors (NK<SUB>1</SUB> and NK<SUB>2</SUB>. respectively) in mediating responses of lamina I dorsal horn neurons, using selective agonists and antagonists in a number of different approaches. A proportion of lamina I cells may receive direct monosynaptic contacts from small diameter primary afferents, respond to nociceptive stimuli and are believed to undergo prolonged changes in res

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31

HIRNING, LANE DURAND. "MULTIPLE PEPTIDE RECEPTORS AND SITES OF ACTION IN THE CANINE SMALL INTESTINE (OPIOIDS, MOTILIN, TACHYKININS, INTESTINAL MOTILITY, SUBSTANCE P)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/188150.

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Motility of the small intestine is a result of complex neurochemical and hormonal interactions within the intestine. The net motility (contraction) of the intestine is a balance of the influences from the central nervous system, enteric nervous system and hormonal changes in the body. Recently, the discovery of several peptide neurotransmitters common to the brain and the intestine has stimulated new research into the influence of these novel neurotransmitter candidates on intestinal motility at the level of the enteric (intestinal) nervous system. The present studies examined the contractile

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32

Deliconstantinos, Gina. "Method development for identification of tachykinins and their post-translational modifications and discovery with in silco analysis of bio-informatic databases." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/26560/.

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Tachykinins are signalling peptides released by the processing of preprotachykinin precursors, which are subject to post-translational modifications including amidation. Tachykinins act on the three tachykinin receptors NKl, NK2 and NK3. Differential processing of the preprotachykinin precursors can lead to the formation of a diverse range of tachykinins (including extended forms). Our previous findings have shown increased proteolytic cleavage of the human TAC3 and TAC4 preprotachykinin precursors by the placenta in pathological conditions such as pre-eclampsia comparable to that found in the

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33

Wagner, Sabine. "Tachykinine und Tachykinin-Rezeptoren in der Innervation der Lunge der Maus : Veränderungen bei Hypoxie und BDNF-Überexpression /." Giessen : Köhler, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014610775&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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34

Campo, Aurora. "Characterization of tachykinin system and role in reproduction in the European eel." Thesis, Paris, Muséum national d'histoire naturelle, 2018. http://www.theses.fr/2018MNHN0027/document.

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L’objectif de cette thèse est d’étudier le rôle de neuropeptides cérébraux, telle que la Neurokinin B codée par le gène tac3, dans le contrôle de la reproduction d’une espèce en danger, l’anguille Européenne, Anguilla anguilla. La maturation sexuelle de l’anguille est bloquée à un stade prépubertaire avant la migration océanique. Etant donnée sa position phylogénétique basale parmi les téléostéens, l’anguille est un modèle pertinent pour étudier l’évolution moléculaire et fonctionnelle de neuropeptides d’intérêt. Deux gènes paralogues tachykinine 3 (tac3) ont été identifiés dans le génome de l

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35

Duplaa, Hélène. "Interactions tachykinines/recepteurs et tachykinines/membranes." Paris 6, 1988. http://www.theses.fr/1988PA066220.

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36

Duplaa, Hélène. "Interactions tachykinines/récepteurs et tachykinines/membranes." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376133395.

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37

Upton, Richard J. "NMR studies of tachykinin analogues." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/33964.

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The tachykinins are highly active mediators of neuronal action in the CNS. In order to understand their action and provide templates for drug development, analogues based on the active sequence of Substance P have recently been synthesised. These analogues often have conformational constraints incorporated into their sequence. For instance, the linear agonists [L and D-Pro9]SP6-11 (l) & (2) and [SucAsp6, NMePhe8]SP6-11 (3) have receptor subtype selectivities for NK1, NK2 and NK3 respectively. The novel cyclic peptides [GlnTrpPheGlyLeuMet] (4) and [GlnTrpPheGly[ANC-2]MetLeu] (5), and their line

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38

Cunningham, Janet Lynn. "Tumour Biological Factors Characterizing Metastasizing Serotonin-producing Ileocaecal Carcinoids." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7906.

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39

Macquin-Mavier, Isabelle. "Tachykinines, bronchoréactivité et inflammation des voies aériennes." Paris 12, 1994. http://www.theses.fr/1994PA120044.

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Parmi les nombreux peptides identifies dans les voies aeriennes, les tachykinines, notamment la substance p et la neurokinine a, suscitent beaucoup d'interet en raison de leurs effets pulmonaires bronchoconstricteurs et pro-inflammatoires et de leur possible implication dans la maladie asthmatique. Dans ce travail, nous avons recherche le role des tachykinines dans l'hyperreactivite et les phenomenes inflammatoires des voies aeriennes observees dans trois modeles experimentaux chez le cobaye: un modele d'exposition a un agent anti-parasitaire, l'isethionate de pentamidine, un modele d'expositi

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40

Maillet, Emeline. "Dynamique des récepteurs aux tachykinines : Modulation allostérique." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13163.

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Les récepteurs couplés aux protéines G (RCPGs) représentent la plus grande famille de récepteurs cellulaires de surface. Les RCPGs sont constitués par une seule chaîne poly-peptidique comportant sept régions hydrophobes transmembranaires, associée à un groupe hétéro-trimérique de protéines intracellulaires : les protéines G. Ces protéines sont constituées d'une sous-unité Ga liée au GDP et de deux sous-unités Gbg indissociables. Lorsqu'ils sont activés par leur ligand, les RCPG catalysent l'échange du GDP par du GTP. Les protéines Ga d'une part, et Gbg d'autre part, deviennent alors capables d

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41

Nguyen, Quang Trinh. "Identification et caractérisation pharmacologique des sous-types de récepteurs NK-1 et NK-3 des neurokinines." Sherbrooke : Université de Sherbrooke, 1997.

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42

Loeuillet, Dominique. "Analyse des interactions tachykinines-recepteurs : etudes biochimiques et structurales." Paris 6, 1989. http://www.theses.fr/1989PA066321.

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Trois tachykinines (la substance p, la neurokinine a et la neurokinine b) et trois recepteurs specifiques de ces peptides (nk-1, nk-2 et nk-3) ont ete caracterises chez les mammiferes. Sp arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-met-nh#2 nk-1. Nka his-lys-thr-asp-ser-phe-val-gly-leu-met-nh#2 nk-2. Nkb asp-met-his-asp-phe-phe-val-gly-leu-met-nh#2 nk-3. Pour preciser les roles physiologiques associes a ces trois tachykinines, des agonistes selectifs de chacun des recepteurs sont necessaires. A partir d'un modele de conformation bvioaffine d'agonistes nk-1, deduit de l'analyse structurale de la su

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43

Lang, Crichton Walker. "Controls of tachykinin release in the mammalian spinal cord." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/29841.

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The purpose of this series of investigations was to elucidate the endogenous control mechanisms active at primary afferent terminals of nociceptive origin in the dorsal laminae of the spinal cord grey matter. Such studies may enable the researcher to make certain conclusions about endogenous mechanisms of pain control in vivo. Furthermore, these studies may help to identify novel areas for the development of analgesic drugs or protocols of therapeutic value in both human and veterinary pain management. Experiments were centred on one particular family of neuropeptides, the tachykinin peptides,

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44

Dion, Stéphane. "Récepteurs des tachykinines. Caractérisation par les agonistes et les antagonistes." Mémoire, Université de Sherbrooke, 1985. http://hdl.handle.net/11143/11677.

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Les résultats présentés dans ce mémoire portent sur la substance P (SP) et d'autres peptides appellés tachykinines. Pendant longtemps, la SP était la seule tachykinine connue chez les mammifères; récemment, deux nouvelles tachykinines ont été découvertes, soit la neurokinine A (substance K, SK) et la neurokinine B (neuromédine K, NK).Dans un premier temps, nous avons cherché des tissus sensibles aux tachykinines pour développer des préparations pharmacologiques adéquates à l'étude des effets biologiques (généralement des effets contractiles) et des récepteurs des tachykinines. Parmi plusieurs

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45

Calvet, Jean-Henri. "Implication des tachykinines dans les lésions respiratoires induites par l'ypérite." Paris 12, 1995. http://www.theses.fr/1995PA120051.

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L'yperite fait partie des armes chimiques dont le risque d'utilisation est le plus important en raison de la simplicite de sa synthese et de son emploi. La peau, l'il et l'appareil respiratoire constituent les principales cibles de cet agent alkylant. Bien que les lesions respiratoires soient la principale cause de mortalite et a l'origine de la morbidite la plus grave, leurs effets ont ete peu etudies. Dans ce travail, nous avons mis au point un modele animal pour 1) decrire les lesions respiratoires induites par l'yperite et leur reparation, 2) pour etudier les consequences fonctionnelles d'

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46

Smyth, Anita F. "Biochemical and biological studies on the dermal venom of the African hyperolid frog, Kassina maculata." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252320.

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47

D'Agostino, Bruno. "Rôle des tachykinines dans la transmission nerveuse au niveau des voies aériennes." Paris 5, 2001. http://www.theses.fr/2001PA05S023.

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Les objectifs de cette thèse ont été d'étudier le rôle des tachykinines dans la transmission nerveuse au niveau des voies aériennes. Nous avons ainsi : 1) examiné le rôle des tachykinines dans la potentialisation par l'endotheline-1 de la contraction des bronches humaines isolées induite par la stimulation électrique des nerfs cholinergiques ; et 2) étudié chez le lapin, dans un modèle de reflux gastrooesophagien, le rôle des tachykinines dans la bronchoconstriction et l'extravasation plasmatique au niveau des voies aériennes induites par l'instillation d'HCI dans l'oesaphage. L'endotheline-1

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48

Foroutan, Arash. "Biophysical Studies of the Tachykinin Peptides: Structural Characterization and Membrane Interactions." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/107884.

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En aquesta tesi doctoral, s’han aplicat metodologies biofísiques per estudiar i caracteritzar l'estructura dels pèptids substància P (SP), neuroquinina A (NKA) i scyliorinina I (ScyI), que pertanyen a la família de les taquiquinines (TK), així com la seva manera d'interacció amb membranes model. Els pèptids TKS són agonistes dels receptors de neuroquinina acoblats a la proteïna G. Els TKS estan involucrats en diversos processos fisiològics i malalties com el càncer, malalties neurodegeneratives i respostes inflamatòries, i això els converteix en un objecte de gran interès per a l'estudi estruc

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49

Barr, Alastair J. "Biochemical studies on the NKâ†1 tachykinin receptor signal transduction pathway." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357379.

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Hooper, Nigel Mark. "Metabolism of neuropeptides by cell-surface peptidases." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235486.

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