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Teses / dissertações sobre o tema "TRIM18"

Autor: Grafiati

Publicado: 1 de abril de 2023

Última modificação: 31 de julho de 2025

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1

FERNANDES, LAGES INES. "Identification of Deubiquitinases (DUBs) associated with TRIM18/MID1." Doctoral thesis, Università degli Studi di Trieste, 2023. https://hdl.handle.net/11368/3042038.

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Ubiquitination is a post-translation modification process crucial to control protein degradation, localization, and activity. Tripartite Motif (TRIM) proteins participate in the ubiquitination process behaving as E3 ubiquitin ligases, responsible for the specific recognition of the substrate to be ubiquitinated. In the opposite process, Deubiquitinating enzymes (DUBs) can deconjugate the ubiquitin from the protein target. The antagonism of DUBs and E3s is essential to maintain protein homeostasis and signaling in cells. In this project, we focused on TRIM18 (also named MID1) that when mutated

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ZANCHETTA, MELANIA EVA. "BRAF35 as target of MID1/TRIM18 E3 ligase activity." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908069.

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TRIM proteins are a family of ubiquitin E3 ligase enzymes characterized by the presence of a conserved N-terminus, the tripartite motif, which consists of a RING finger domain, two B-box motifs and an alpha-helical Coiled-coil region (RBCC). We focused our attention on TRIM18/MID1, the gene responsible for the X-linked form of Opitz G/BBB syndrome, a congenital disease characterized by defects in midline development and mental retardation. More recently, MID1 has also been found as overexpressed in some aggressive prostate cancers. The role of MID1 within the cell and the target(s) of its E3 u

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MASCARO, MARTINA. "Ruolo di TRIM18, gene che causa la sindrome di Opitz, nel controllo della ciliogenesi attraverso l'autofagia." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996095.

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TRIM18/MID1 è una E3-Ubiquitina ligasi appartenente alla famiglia di proteine TRIM che si localizza sui microtubuli. Le mutazioni con perdita di funzione nel gene MID1 sono state associate alla forma legata all'X della sindrome di Opitz, una malattia genetica caratterizzata da difetti nello sviluppo della linea mediana ventrale. All'interno della cellula, MID1 esiste come un complesso macromolecolare microtubulare, costituito da diversi interattori non tutti ancora identificati. Tra questi, α4 è una delle subunità regolatorie della proteina fosfatasi 2A (PP2A). È stato riportato che MID1 riduc

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Basu, Shrivastava Meenakshi. "Régulation de la stabilité de NFATc3 par SUMO et les E3 ubiquitine-ligases Trim39 et Trim17." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT043.

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Les facteurs de transcription NFAT (facteur nucléaire des cellules T activées) jouent un rôle physiologique important dans le développement et le fonctionnement de nombreux organes, notamment dans le système immunitaire et le système nerveux. Par conséquent, leur dérégulation a été impliquée dans diverses maladies humaines telles que le cancer, les maladies neurodégénératives et les maladies auto-immunes. La régulation de l'activité de NFAT par translocation nucléo-cytoplasmique a été largement étudiée. En revanche, la régulation du niveau protéique de NFAT par le système ubiquitine-protéasome

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5

Buberl, Cilli Dana [Verfasser]. "Expressionsanalyse der putativen E3 Ligasen Trim23 und Trim7 in der frühen Neuralentwicklung von Xenopus laevis / Cilli Dana Buberl." Halle, 2017. http://d-nb.info/1137867698/34.

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6

Borle, Pawar Ankush [Verfasser], Norbert [Akademischer Betreuer] Frey, and Dennis [Gutachter] Schade. "Functional characterization of TRIM24 and TRIM32 proteins in the heart through their interaction with Dysbindin / Ankush Borle Pawar ; Gutachter: Dennis Schade ; Betreuer: Norbert Frey." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1220691259/34.

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7

Locke, Matthew. "TRIM32 in Genetic Disease." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514962.

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8

VENUTO, SANTINA. "Dissecting the TRIM8 role in the pathogenesis of glioma." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382357.

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I gliomi umani sono un gruppo eterogeneo di tumori cerebrali maligni primari, la cui patogenesi molecolare risulta ancora parzialmente sconosciuta. Pertanto, la comprensione dei meccanismi molecolari alla base della loro insorgenza e del loro decorso può portare a una migliore scelta di terapie appropriate e a migliori risultati prognostici, attraverso l'identificazione di nuovi geni specifici associati al glioma. Le proteine appartenenti alla famiglia “tripartite motif” (TRIM) sono coinvolte in diversi processi biologici, tra cui la regolazione trascrizionale, il controllo della progressione

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9

Crichton, Jennifer E. "The Role of the E3-ubiquitin Ligase Trim17 in the Mitochondrial Cell Death Pathway." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23715.

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The upregulation of apoptosis is a hallmark of several neurodegenerative disorders including ischemic stroke. In neurons, as in other cell types, Bax and tBid are critical regulators of the intrinsic pathway upstream of mitochondrial outer membrane permeabilization (MOMP) and caspase activation. The characterization of the molecular events that occur during the early stages is therefore extremely important from a therapeutic standpoint. Here I show that two independent genetic pilot screens looking for novel regulators of Bax activation identified a common hit in the E3 ubiquitin ligase Trim17

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10

Simpson, Shmona. "Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:1af588ba-603a-4f39-9443-bb1a95d983f5.

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HIV-2 differs from HIV-1 in that many infected people experience normal survival, whilst only 20&percnt; progress rapidly to AIDS. Understanding mechanisms of delayed HIV-2 disease progression could provide new insights into HIV control. The Caio Community Cohort was established in Guinea-Bissau in the setting of high HIV-2 prevalence. This thesis investigates the role of polymorphic host restriction factors of the TRIM family in HIV-2 outcome. TRIM proteins are a family of E3 ubiquitin-ligases, where closely-related TRIM5α and TRIM22 are thought to inhibit HIV-1 transcription, uncoating

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Guimarães, Dimitrius Santiago Passos Simões Fróes. "Caracterização bioquímica e celular da proteína TRIM49." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-10042018-112409/.

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A autofagia é o processo de degradação de estruturas celulares através do seu direcionamento ao lisossomo. As proteínas TRIMs reconhecem as -cargas? autofágicas e reúnem o complexo de nucleação do fagóforo, contudo se desconhece a função de cada domínio e a importância da atividade de E3 ligase para a sua atividade. A proteína TRIM49 clonada e expressa em E. coli ou em células humanas HEK293T não apresentou atividade de E3 ubiquitina ligase in vitro e reduziu os níveis totais de ubiquitinação in vivo, indicando que não é um E3 ubiquitina ligase. Células desafiadas com Htt74Q apresentaram menor

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12

Bartsch, Frederike [Verfasser], and Elke [Akademischer Betreuer] Cario. "Funktion und Regulation von TRIM58 in der myeloischen Immunabwehr / Frederike Bartsch ; Betreuer: Elke Cario." Duisburg, 2019. http://d-nb.info/1196008418/34.

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13

McGuire, Cy Christopher. "Evaluation of PGR properties of TRIMAX in cotton." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2605.

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Pesticides comprise a large portion of production inputs in cotton. Reducing or enhancing their efficacy presents an avenue to increase profit. Pesticides containing both insecticidal and growth enhancing properties may be a viable option to increased profitability. In cotton (Gossypium hirsutum L.), early season applications of some insecticides have shown effects similar to those of plant growth regulators (PGRs). TRIMAX?? (imidacloprid) is one of these purported PGR insecticides. TRIMAX?? and Centric?? 40WG (thiamethoxam), both nitroguanidine insecticides, have properties that may exhibit P

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14

Roberts, Simon Benedict. "Investigating new genetic susceptibility loci in osteoarthritis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28982.

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Primary osteoarthritis (OA) is a late-onset, degenerative condition of synovial joints, and is the major cause of pain and disability in older persons. OA represents a significant disease burden and focus of research, especially as no disease-modifying therapies exist to manage the condition. The genetic influence to OA is complex and polygenic. The arcOGEN study, the most powerful genome-wide association study yet to investigate OA in humans, identified the 9q33.1 locus to be significantly associated with hip OA in females. TRIM32 lies within the 9q33.1 susceptibility locus and may have stron

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15

Reusse, Ekaterina [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Heiko [Gutachter] Hessenkemper. "Innovative industrielle Erdgasbeheizungssysteme auf der Basis der Porenbrennertechnologie für Hochtemperaturanwendungen / Ekaterina Reusse ; Gutachter: Dimosthenis Trimis, Heiko Hessenkemper ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://d-nb.info/1220911461/34.

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Frenzel, Isabel [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Sven [Gutachter] Kureti. "Flammenstruktur und Rußbildung in Verbrennungsprozessen mit ethanol- und butanolhaltigen Kraftstoffen / Isabel Frenzel ; Gutachter: Dimosthenis Trimis, Sven Kureti ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universität Bergakademie Freiberg, 2018. http://d-nb.info/1226101038/34.

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17

Schaller, T. "Characterisation of TRIM5α and related retroviral restriction factors". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18779/.

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Retroviruses possess an RNA genome that is reverse transcribed into DNA and becomes integrated into the host genome during infection. Human immunodeficiency virus 1 (HIV-1) belongs to the genus lentivirus of the retroviridae family and is a major human pathogen with more than 50 million infected people worldwide to date. Lentiviruses have very narrow host ranges. Cross-species lentiviral transmissions are rare, due to the ability of mammals to counteract viral infections by the innate immune system, which includes intracellular factors that block virus replication. Of these, the murine protein

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18

Reddi, Tejaswini Satya. "TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17464655.

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The host response to the family of nuclear replicating DNA viruses or the herpesviruses includes the intrinsic, innate and adaptive arms of the immune system. Intrinsic resistance is a constitutively active line of defense against virus infections and members of the Tripartite Motif (TRIM) superfamily of proteins; such as TRIM5 and TRIM19/PML in nuclear domain 10 (ND10) bodies are important restriction factors in this system. Nuclear intrinsic restriction against the prototypical DNA virus, herpes simplex virus 1 (HSV-1) includes interferon-inducible protein 16 (IFI16) and ND10 bodies. However

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19

Jerabkova, Katerina. "Les rôles de Trim15 et UCHL3 dans la régulation, médiée par l’ubiquitine, du cycle cellulaire." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ034.

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La mitose est précisément contrôlée par la signalisation via l'ubiquitine et est essentielle au maintien de l'intégrité du génome. Dans ce travail, j'ai étudié la fonction de l'enzyme de dé-ubiquitination, UCHL3 et de la ligase E3-ubiquitine, TRIM15. J'ai observé que TRIM15 régule l'adhésion et la mobilité des cellules. UCHL3 a été identifié par un criblage à haut contenu, en tant que facteur critique contrôlant l'alignement et la ségrégation des chromosomes. Fait intéressant, il a déjà été rapporté que les niveaux d’expression d’UCHL3 sont altérés dans divers types de cancer. En utilisant une

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20

Anger, Stephan [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Angelika [Gutachter] Heinzel. "Untersuchungen zur Prozessgasaufbereitung von Flüssiggas für die Dampfreformierung in Brennstoffzellen-BHKW / Stephan Anger ; Gutachter: Dimosthenis Trimis, Angelika Heinzel ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2016. http://d-nb.info/122091231X/34.

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21

Rau, Florian [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Andreas Siegfried [Gutachter] Bräuer. "Einsatz biogener Kraftstoffe zur Senkung der Emissionen von stationären Verbrennungsmotoren / Florian Rau ; Gutachter: Dimosthenis Trimis, Andreas Siegfried Bräuer ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universität Bergakademie Freiberg, 2021. http://d-nb.info/1240475837/34.

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22

Kim, Kyusik. "HIV-1 Evasion of Human TRIM5α via Cyclophilin A". eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1089.

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The abundant cellular protein Cyclophilin A (CypA) was found to bind to HIV-1 capsid (CA) in 1993. Since that time, several complementary methods, including disruption of the binding interface by cyclosporine A, CA mutants, and CypA mutants, have been used to demonstrate that CypA acts within human target cells to promote HIV-1 infection. In contrast, in cells from non-human primates, CypA in target cells decreases HIV-1 infectivity, and it does so by promoting TRIM5α-mediated restriction. Using human cancer cell lines and the genetic methods available at the time, attempts to obtain evidence

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23

Bouchard, Amélie. "Évolution moléculaire in vitro du facteur de restriction TRIM5α". Thèse, Université du Québec à Trois-Rivières, 2009. http://depot-e.uqtr.ca/1462/1/030123866.pdf.

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24

Hao, Chengcheng. "Improved Sampling-based Alpha Matting in Images and Video." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23417.

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Foreground extraction technology plays an important role in image and video processing tasks. It has been widely used in various industries. To better describe the overlap relationship between foreground and background, alpha channel is introduced. It reveals the opacity property of foreground objects. Thus, fully extracting a foreground object requires determining the alpha values for pixels, also known as extracting an alpha matte. In this thesis, we propose an improved sampling-based alpha matting algorithm, which is capable of generating high quality matting results. By analyzing the weak

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25

Yeo, Richard Fraser. "The three dimensional simulation of VLF signal scattering." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286749.

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Walter, Christopher John. "Stereoselective acceleration of Diels-Alder reactions by synthetic enzymes." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272679.

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Schulz, Bastian [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Jens-Uwe [Gutachter] Repke. "Entwicklung eines Reformierungssystems zur Bereitstellung von Synthesegas für den maritimen Betrieb einer MCFC-Brennstoffzelle / Bastian Schulz ; Gutachter: Dimosthenis Trimis, Jens-Uwe Repke ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://d-nb.info/1220837377/34.

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Schank, Troy C. "Optimal aeroelastic trim for rotorcraft with constrained, non-unique trim solutions." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22654.

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Thesis (Ph. D.)--Aerospace Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Dimitri N. Mavris; Committee Co-Chair: Daniel P Schrage; Committee Member: David A. Peters; Committee Member: Dewey H. Hodges; Committee Member: J.V.R. Prasad.

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Blaia, Junior Antonio Carlos Teixeira [UNESP]. "Geração automática de Trimap para Matting Digital de Imagens e Vídeo." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/89346.

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Made available in DSpace on 2014-06-11T19:24:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-04Bitstream added on 2014-06-13T19:51:05Z : No. of bitstreams: 1 blaiajunior_act_me_sjrp.pdf: 2879763 bytes, checksum: eed492b07eec826c96bf8194c8560a7c (MD5)<br>Técnicas de composição de imagens, com extração de objetos em primeiro plano para serem combinados com um novo plano de fundo, são muito utilizadas em aplicações que vão desde simples montagens em fotos até produções cinematográficas. Estas técnicas são chamadas demattingdigital. Com elas é possível minimizar custos das produções

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Port, Yasmine [Verfasser]. "The Role of TRIM71 in Male Germ Cell Development / Yasmine Port." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1240761260/34.

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Blaia, Junior Antonio Carlos Teixeira. "Geração automática de Trimap para Matting Digital de Imagens e Vídeo /." São José do Rio Preto, 2013. http://hdl.handle.net/11449/89346.

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Orientador: Antonio Carlos Sementille<br>Banca: João Fernando Marar<br>Banca: Ildeberto Aparecido Rodello<br>Resumo: Técnicas de composição de imagens, com extração de objetos em primeiro plano para serem combinados com um novo plano de fundo, são muito utilizadas em aplicações que vão desde simples montagens em fotos até produções cinematográficas. Estas técnicas são chamadas demattingdigital. Com elas é possível minimizar custos das produções, uma vez que o ator não precisa estar realmente no local onde a cena irá acontecer. Esta característica também viabiliza sua utilização em programas re

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Zhang, Xuzhe. "Eutherian-specific gene TRIML2 attenuates inflammation in the evolution of placentation." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573576401238203.

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Watkinson, Ruth Elizabeth. "Intracellular antibody receptor TRIM21 in viral neutralisation and innate immune signalling." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708305.

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34

Conwell, Sara. "TRIM27 in HSV-1 Infection: A Story of Loss and Death." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463971.

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During viral infection, the host subjects the virus to an array of protective mechanisms. Viruses have evolved evasion strategies to thwart these defenses, and must simultaneously regulate multiple cellular pathways and resources to achieve successful replication. To orchestrate such complex regulation, viruses, including herpes simplex virus 1 (HSV-1), rely on multifunctional proteins such as the E3 ubiquitin ligase ICP0. This protein counteracts various host defenses by targeting cellular factors for degradation. We undertook a proteomic screen to identify binding partners of ICP0, and id

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Veillette, Maxime. "TRIM5α : spécificité d'action, résistance virale et implications pour la thérapie génique". Thèse, Université du Québec à Trois-Rivières, 2013. http://depot-e.uqtr.ca/6956/1/030596123.pdf.

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Tag, Andrew George. "Characterization of the Tri10 gene from Fusarium sporotrichioides." [College Station, Tex. : Texas A&M University, 2003. http://hdl.handle.net/1969.1/64.

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Thesis (Ph.D.)--Texas A&M University, 2003.<br>"Major Subject: Plant Pathology" Title from author supplied metadata (record created on Jul. 18, 2005.) Vita. Abstract. Includes bibliographical references.

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Demasi, João Otavio Benevides. "Os investimentos internacionais e a reforma das TRIMs." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/2/2135/tde-03122012-160404/.

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Devido ao colapso da economia americana, em 2009, os Fluxos de Capitais foram somente da Ordem Econômica de US$ 1.8 trilhões, 82% menos do que em 2007 (US$ 10.5 trilhões). Em 2009, o volume de comércio diário de ativos foi de US$ 1.5 trilhões, com US$ 178 trilhões como ativos financeiros. Os Investimentos Internacionais produtivos são uma das bases da internacionalização de empresas e do capital. Ao estabelecer uma planta industrial e/ou adquirir ações de empresas, este fluxo transfronteiriço de capital aporta bens, tecnologia, novas práticas administrativas, inter alios actos, e se distingue

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Gil, Mir Maria Eugenia. "Expanding the MDM2 interactome." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25781.

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p53 is a key component of the protein network that regulates cell cycle progression and prevents cancer. Under non-stressed conditions, its activity is controlled by an autoregulatory feedback loop with MDM2 that maintains low levels of the p53 protein. However, in response to stress signals, p53 is triggered to become active. MDM2 has been reported to regulate p53 by a combination of mechanisms: ubiquitination using its E3-ligase capability, chaperone activity in an ATP-dependent manner and directly transrepressing p53. Because of MDM2's central role in the control of p53, it has been the tar

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Eder, Robert [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis, and Eckehard [Gutachter] Specht. "Ein Beitrag zur Entwicklung neuartiger keramischer Wärmeübertrager für Rekuperatorbrenner : Ein Beitrag zur Entwicklung neuartiger keramischer Wärmeübertrager für Rekuperatorbrenner / Robert Eder ; Gutachter: Dimosthenis Trimis, Eckehard Specht ; Betreuer: Dimosthenis Trimis." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2015. http://d-nb.info/1220911976/34.

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Schneider, Karin [Verfasser]. "Untersuchung der molekularen Funktion des Stammzellfaktors Trim71 in der Karzinogenese / Karin Schneider." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1109879881/34.

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Hennig, Janosch. "Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases /." Linköping : Department of of Physics, Chemistry and Biology, Linköping University, 2009. http://www.bibl.liu.se/liupubl/disp/disp2009/tek1272s.pdf.

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Bérubé, Julie. "Influence de l'environnement cellulaire sur l'activité des protéines antirétrovirales TRIM5α et TRIMCyp". Thèse, Université du Québec à Trois-Rivières, 2011. http://depot-e.uqtr.ca/2264/1/030276729.pdf.

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Mielnicka, Monika. "Study of the biological function of TRIM66 protein in spermatogenesis and reproduction." Thesis, Strasbourg, 2022. http://www.theses.fr/2022STRAJ077.

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TRIM66 est un membre de la famille de protéines TIF1 composée de TRIM24, TRIM28 et TRIM33, qui ont un domaine tandem PHD-bromodomaine en C-terminal. TRIM66 est le membre le moins étudié de cette famille et montre une haute spécificité vers l'expression dans la lignée germinale mâle, spécifiquement dans la population de cellules testiculaires haploïdes appelées spermatides. Le processus de maturation des spermatozoïdes dans les cellules haploïdes est appelé spermiogenèse et au cours de ce processus, un remodelage majeur de la chromatine a lieu avec le remplacement des histones canoniques par de

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Yehouessi, Mawena. "Poïéthiques afrofuturistes : Trimer trames à l'intersection du collage et de la curation." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ2043.

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À travers l’essai, la poésie, la citation et la traduction, cette recherche déroule un corpus lianescent, aux croisements des études noires, de l’afrofuturisme et de contre-phénoménologies alternatives (et queerféministes en particulier), visant à remettre en question nos différentes manières de « faire image ». Elle concerne en effet le parcours de formes et de protocoles minorisés – aussi bien artistiques que conceptuels –, qui associent pourtant le renouvellement syncrétique des imaginaires et des canons esthétiques à de fortes motivations éthiques, dans la perspective du déploiement de str

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Balastik, Martin. "Trim2 mutant mice as a model for cerebellar ataxia." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975117025.

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Larrieu, Dorian. "Régulation et fonctions de l'E3 ubiquitine ligase TRIP12 au cours du cycle cellulaire." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30144.

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TRIP12 est une E3 ubiquitine ligase de la famille HECT (Homologous to the E6-AP Carboxyl Terminus). TRIP12 a plusieurs cibles connues qu'elle adresse au protéasome par polyubiquitination. Parmi ces cibles, plusieurs protéines ont des rôles importants dans la réponse aux dommages à l'ADN, le remodelage de la chromatine et la voie d'activation de p53. Des résultats non publiés de mon équipe d'accueil ont montré une surexpression de la protéine TRIP12 dans le cancer du pancréas et les lésions pré-néoplasiques. Le groupe a mis en évidence que TRIP12 polyubiquitine et provoque la dégradation du fac

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Haubrich, Kevin [Verfasser], and Carsten [Akademischer Betreuer] Sachse. "RNA binding regulates TRIM25-mediated RIG-I ubiquitination / Kevin Haubrich ; Betreuer: Carsten Sachse." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1235674649/34.

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Falcón, Beas Felipe Ernesto. "¿Pueden las células dendríticas maduradas con trimel activar células INKT contra melanoma humano?" Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/168208.

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Grado de doctor en ciencias biomédicas.<br>Melanoma es la neoplasia cutánea más agresiva, con una incidencia ascendente a pesar de numerosos esfuerzos de prevención. En la actualidad existen diversas estrategias de tratamiento, sin embargo, no todos los pacientes responden a ellas. En nuestro laboratorio se ha ensayado una inmunoterapia basada en células dendríticas (DCs) maduradas con un lisado de líneas celulares de melanoma (TRIMEL), que ha incrementado hasta 3 veces la sobrevida en pacientes que desarrollan una respuesta inmunológica de hipersensibilidad retardada (DTH+). Hasta la fecha no

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Pillera, Giuseppe Carmelo. "Trimap: social networked learning e social mapping per il terzo settore in Sicilia." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1147.

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La tesi illustra le basi teoriche, il contesto sociale dell'operazione, i percorsi progettuali e i primi risultati relativi alla creazione e sperimentazione di Trimap (www.trimap.it), un progetto (nato all'interno di questo dottorato) di mappatura dal basso e di social learning per il mondo del no-profit. Gli obiettivi principali sono: 1) costruire in maniera partecipativa un sistema informativo geografico (GIS) sul noprofit attraverso un sistema di mappe interattive; 2) fornire alle organizzazioni partecipanti uno spazio di autorappresentazione, comunicazione, confronto, cooperazione, c

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XIONG, Lu. "Role of TRIM32, the ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy R8." Doctoral thesis, Università degli Studi di Trieste, 2023. https://hdl.handle.net/11368/3042039.

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Mutations in TRIM32 result in the inherited disease Limb-girdle muscular dystrophy Recessive 8 (LGMDR8), a neuromuscular disorder manifesting in the proximal muscles around the hips and shoulders. TRIM32 is a RING E3 ligase belonging to the tripartite motif family (TRIM), which functions in the last step of ubiquitination, transferring the ubiquitin from E2 conjugating enzyme to specific substrates based on its ability to recognize different proteins. In literature, some studies report the critical role of TRIM32 in muscle physiology, muscle atrophy, muscle regeneration, as well as neuronal di

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