Bibliografias temáticas / Varioline

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Literatura científica selecionada sobre o tema "Varioline"

Autor: Grafiati
Publicado: 4 de junho de 2021
Última modificação: 18 de fevereiro de 2022

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Artigos de revistas sobre o assunto "Varioline"

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Vaquero, J., A. Baeza, J. Mendiola, C. Burgos e J. Alvares-Builla. "Synthesis of Pyridopyrrolopyrimidines. Total Synthesis of Varioline B and Deoxyvariolin B". Synfacts 2010, n.º 12 (22 de novembro de 2010): 1343. http://dx.doi.org/10.1055/s-0030-1258954.

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Huth, Stephanie. "Variolink Esthetic". Tandartspraktijk 36, n.º 1 (fevereiro de 2015): 66–67. http://dx.doi.org/10.1007/s12496-015-0016-5.

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Rosentritt, Martin, Michael Behr, Carola Kolbeck e Gerhard Handel. "Marginal Integrity of CAD/CAM Fixed Partial Dentures". European Journal of Dentistry 01, n.º 01 (janeiro de 2007): 025–30. http://dx.doi.org/10.1055/s-0039-1698308.

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ABSTRACTObjectives: Computer-aided design (CAD) and manufacturing (CAM) allows the milling of high strength zirconia fixed partial dentures (FPD), however bonding to an inert ZrO2 ceramic surface may effect the marginal integrity of the FPDs. The aim of this investigation was to evaluate the marginal adaptation of zirconia FPDs at the interfaces between zirconia, cement, and tooth.Methods: Methods: 32 3-unit FPDs were fabricated of the CAD/CAM Y-TZP zirconia (Lava, 3M Espe, Germany) according to the manufacturers’ instructions. Resin cements with corresponding primer and bonding systems were used to lute the FPDs: Compolute/EBS multi (3M Espe, Germany), Panavia F/ED (Kuraray, Japan), Variolink 2/Syntac classic (Ivoclar-Vivadent, FL) and RelyX Unicem/without treatment (3M Espe, Germany). Au-alloy FPDs (BioPontostar, Bego, Germany) were cemented with RelyX Unicem and Harvard (Harvard, Germany) as the control. Marginal adaptation was evaluated with scanning electron microscopy using replica specimen before and after artificial aging. After aging, microleakage tests were performed with fuchsine solution. The interfaces between cement-tooth and cement-FPD were examined.Results: At the interfaces (cement-tooth and cement-FPD), the systems showed a 95% or higher perfect margin before and after aging. Only Variolink2/Syntac had a marginal adaptation, lower than a 70% perfect margin. Generally, the fuchsine penetration was below 20%, only BioPontstar/Harvard and Lava/Variolink2 showed penetration results between 80% and 100%.Conclusion: The success of the adhesive cementation of zirconia FPDs depends on the cement system. Under the conditions of this study, zirconia FPDs showed good to sufficient marginal integrity in combination with Panavia/ED, Compolute/EBS and RelyX Unicem. (Eur J Dent 2007;1:25-30)
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Walker, Scott R., Erin J. Carter, Belinda C. Huff e Jonathan C. Morris. "Variolins and Related Alkaloids". Chemical Reviews 109, n.º 7 (8 de julho de 2009): 3080–98. http://dx.doi.org/10.1021/cr900032s.

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Alkhudhairy, Fahad, Fahim Vohra, Mustafa Naseem, Mosa Mohammed Owais, Abdulmajeed H. Bin Amer e Khalid B. Almutairi. "Color stability and degree of conversion of a novel dibenzoyl germanium derivative containing photo-polymerized resin luting cement". Journal of Applied Biomaterials & Functional Materials 18 (janeiro de 2020): 228080002091732. http://dx.doi.org/10.1177/2280800020917326.

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Aim: To compare the color stability and degree of conversion (DC) of a resin cement containing a dibenzoyl germanium derivative photo-initiator (Variolink Esthetic) to resin cements containing conventional luting agents. Materials and Method: Spectrophotometry and Fourier transform infrared spectroscopy (FTIR) were used to compare the color stability and DC, respectively, of Variolink Esthetic compared to Calibra, Variolink-N, and NX3 resin cements. Ten specimens (1 × 2 mm2) of each resin cement were photo-polymerized and then subjected to color stability assessments. In addition, 30 samples of each of the four resin cements were prepared and then immersed in three staining solutions (tea, coffee, and distilled water) for two weeks. Changes in color for the immersed versus non-immersed specimens (control specimens) were determined by comparing ΔL (lightness), Δa, and Δb (color components), and an overall ΔE (color difference) obtained from spectrophotometry assays. One-way analysis of variance and a multiple comparison test (Tukey’s test) were used to analyze color stability and DC data. NX3 and Variolink Esthetic resin cements exhibited significantly lower values compared to the dual cured resin cements (Variolink-N and Calibra). Results: The highest DC values were observed among the photo-polymerized samples of Variolink Esthetic (87.18 ± 2.90%), while the lowest DC values were observed among the Variolink-N samples (44.55 ± 4.33%). Conclusion: The resin cement, Variolink Esthetic, containing a novel dibenzoyl germanium derivative photo-initiator exhibited superior color stability ( p < 0.05) and a higher DC than other resin cements containing conventional luting agents in an in vitro setting.
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Ahaidar, Abderaouf, David Fernández, Olga Pérez, Gerardo Danelón, Carmen Cuevas, Ignacio Manzanares, Fernando Albericio, John A. Joule e Mercedes Álvarez,. "Synthesis of variolin B". Tetrahedron Letters 44, n.º 33 (agosto de 2003): 6191–94. http://dx.doi.org/10.1016/s0040-4039(03)01551-x.

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Anderson, Regan J., e Jonathan C. Morris. "Total synthesis of variolin B". Tetrahedron Letters 42, n.º 49 (dezembro de 2001): 8697–99. http://dx.doi.org/10.1016/s0040-4039(01)01881-0.

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Ramos, NC, JN Luz, MC Valera, RM Melo, GSFA Saavedra e E. Bresciani. "Color Stability of Resin Cements Exposed to Aging". Operative Dentistry 44, n.º 6 (1 de novembro de 2019): 609–14. http://dx.doi.org/10.2341/18-064-l.

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SUMMARY The aim of this study was to evaluate the color stability of light-cured and dual-cured resin cements after artificial accelerated aging. Ten specimens (6-mm diameter and 2-mm thickness) for each of five resin cements were prepared: GC (dual-cured cement, GCem), Vb (light-cured cement, Variolink II only the base), Vbc (dual-cured cement, Variolink II base with catalyst), VV (light-cured cement, Variolink Veneer), and FR (flowable resin composite, light cured). The samples were polished and stored in an accelerated artificial aging machine for 308 hours (160 klx), with cycles of 120 minutes under light and 60 minutes in the dark. All aging was carried out in distilled water at 37°C and light irradiation at 765 W/m2. The samples were evaluated in a spectrophotometer before and after aging, and results were calculated according to CIEDE2000. The data were statistically analyzed (one-way analysis of variance and Tukey test, 95% confidence). The results of ΔE00 were statistically significant for the type of cement (p&lt;0.001), with differences among tested groups. Variolink II (base only and base + catalyst) and the flowable resin were the cements with the lowest color variations after the artificial accelerated aging. Considering the values ΔE00 of acceptability and perceptibility, none of the tested cements showed acceptable values.
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Liu, Qi, Long Quan Shao, Chen Hu, Yuan Fu Yi, Bin Deng e Ning Wen. "Bond Strength of Different Adhesive Luting Materials to Zirconia Ceramics". Key Engineering Materials 512-515 (junho de 2012): 447–50. http://dx.doi.org/10.4028/www.scientific.net/kem.512-515.447.

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To investigate the bond strength of different adhesive luting materials bond to zirconia ceramics. 40 (30mm×5mm×5mm) Cercon Smart Ceramics samples were divided into groups: (1) glass-ionomer bonded (control group), (2) Clearfil™ Repair bonded, (3) Panavia F bonded, (4) Variolink N bonded. Tensile bond strength and shear bond strength were evaluated after 24h storage at 37°C in distilled water. Each group had 10 samples for different test. Data were evaluated using ANOVA analysis (α=0.05). The experiment groups are statistically significant differences with control group (P<0.05). The shear bond strength of the Glass ionomer FX Ι, the Clearfil™ Repair, Panavia F and Variolink N groups were 14.23±4.48 MPa, 21.95±1.32 MPa, 31.16±1.50 MPa and 43.54±1.97 MPa, separately. Comparisons among groups were significant differences (P<0.001). Variolink N bonded ceramics achieved highest tensile and shear bond strength. Different adhesive materials significantly influence the bond strength of zirconia ceramics.
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Anderson, Regan J., e Jonathan C. Morris. "ChemInform Abstract: Total Synthesis of Variolin B." ChemInform 33, n.º 9 (22 de maio de 2010): no. http://dx.doi.org/10.1002/chin.200209220.

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Teses / dissertações sobre o assunto "Varioline"

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Marquise, Nada. "Diarylcétones : synthèse par déprotocupration-aroylation et applications en série azinique". Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S055/document.

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Le but principal de ce travail a été de développer de nouvelles méthodologies pour la synthèse de molécules d'intérêt biologique, telles que des azafluorénones, et des précurseurs d'analogues de la variolines B. Tout d'abord, nous avons synthétisé des diarylcétones, précurseurs pour nos cibles, par une séquence déprotocupration-aroylation. Ensuite, nous les avons impliquées dans une étape de couplage pallado-catalysé : les substrats ont subi une C-H activation pour aboutir aux azafluorénones. Nous nous sommes tournés par la suite vers la synthèse d'azafluorénones substituées. Ces dernières ont été synthétisées par un processus auto-tandem en combinant le couplage de Suzuki ou le couplage de Heck avec la cyclisation intramoléculaire catalysée par le palladium. Certaines de ces molécules ont été évaluées pour leurs propriétés biologiques et ont révélé des bonnes activités cytotoxique, antimalariale, antibactérienne et antifongique. Enfin, nous avons réussi à synthétiser des précurseurs d'analogues de variolines en seulement trois étapes à partir d'un produit commercial
The main purpose of this work was to develop new methodologies for the synthesis of molecules of biological interest, such as azafluorenones and precursors of variolin B analogs. First, we synthesized diarylketones, precursors for our targets, via a deprotocupration-aroylation sequence. Then, we involved them in a pallado-catalyzed coupling step: some substrates underwent C-H activation to provide azafluorenones. Next, we turned our attention to the synthesis of substituted azafluorenones. The latter were synthesized by a tandem process combining Suzuki coupling or Heck coupling with intramolecular cyclization catalyzed by palladium. Some of these molecules were biologically evaluated and showed good biological activities: cytotoxic, antimalarial, antibacterial and antifungal. Finally, we succeeded in synthesizing precursors of variolin analogues in only three steps from a commercial product
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Rutten, Willibrord J. M. J. ""De vreselijkste aller harpijen" : pokkenepidemieën en pokkenbestrijding in Nederland in de achttiende en negentiende eeuw : een sociaal-historische en historisch-demografische studie /". Wageningen : Afdeling Agrarische Geschiedenis Landbouwuniversiteit, 1997. http://catalogue.bnf.fr/ark:/12148/cb371542482.

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Anderson, Regan J. "Total synthesis of variolin B". Thesis, University of Canterbury. Chemistry, 2002. http://hdl.handle.net/10092/6061.

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This thesis describes the development of methodology which has led to the total synthesis of variolin B, a marine alkaloid with potent antitumour properties. In Chapter One, a brief summary of the association of organic synthesis and marine natural products is provided. This is followed by an account of the variolin family of natural products and synthetic efforts that have been directed towards them. A new strategy is proposed that exploits the hidden symmetry in variolin B. Chapter Two covers investigations into the synthesis of the variolin skeleton using a variety of reagent systems. A rapid entry into the core structure of the variolins was found, with the key step being a deoxygenation/cyclisation protocol, which was mediated by the combination of triethylsilane and trifluoroacetic acid. Evidence was obtained to suggest an unexpected mechanism for this reaction. Straightforward functional group manipulation led to a synthesis of deoxyvariolin B. In Chapter Three, the previously established methodology was applied to an alternative starting material, appropriate for a synthesis of variolin B. However, the process was low-yielding and gave variable results. Some modifications to the methodology led to a reliable and efficient procedure for the synthesis of the variolin skeleton, which was subsequently transformed to variolin B. The synthesis proceeded in a total of eight linear steps, with an overall yield of 13%. The methodology which has been developed lends itself to the production of analogues of the variolins. The synthesis and biological testing of some analogues are presented in Chapter Four, along with a discussion on the structural features which confer biological activity on variolin B. A brief summary of the work described in this thesis and potential future studies is given in Chapter Five.
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Lisfranc, Jacques. "Quelques propositions de pathologie, précédées de recherches, réflexions et observations thèse présentée et soutenue à la Faculté de médecine de Paris le 26 août 1813 /". Paris : BIUM, 2003. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1813x135.

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Therrien, Sébastien. "Le rôle joué par le Conseil d'hygiène de la province de Québec dans la prévention de la variole de 1888 à 1922". Sherbrooke : Université de Sherbrooke, 2001.

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Vigne, Solenne. "Inhibition de la réplication des orthopoxvirus par le phénomène d'ARN interférence : perspectives thérapeutiques". Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20659.

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A l’heure actuelle, face à une menace de réémergence de la variole, les recherches se sont axées vers la sélection de molécules anti-poxvirus. Dans ce contexte, les travaux réalisés au cours de cette thèse décrivent la mise en place de la technologie de l’ARN interférence comme stratégie inhibitrice de la réplication des orthopoxvirus. Nous avons évalué l’activité antivirale de plusieurs petits ARN interférents (siRNA), ayant pour cible des transcrits de gènes codant des protéines essentielles à la réplication du virus de la vaccine (VACV). A la suite de cette sélection, trois siRNA ont été retenus : siD5R- 2, ciblant le gène codant la protéine nucléoside triphosphate D5 ; siB1R-2, dirigé contre le gène B1R codant la protéine kinase B1 ; et siG7L-1, dirigé contre le gène G7L codant une protéine clé, G7, de la morphogenèse virale. Une inhibition significative de plus de 90% de la réplication virale des virus VACV, du cowpox (CPXV) et du monkeypox (MPXV), dans différentes lignées cellulaires, a été observée avec chacun de ces siRNA. Nous avons démontré que cette action antivirale est spécifique : les siRNA n’induisent pas l’activation du système interféron, et ils diminuent uniquement l’expression du transcrit ciblé (D5R, B1R ou G7L), comme démontré par RT-PCR en temps réel. De plus, le pouvoir antiviral de ces siRNA, administrés par différentes voies, a été évalué in vivo dans un modèle souris d’infection intra-nasale avec le CPXV ou le VACV. Le cidofovir (Vistide®) reste la molécule de première intention recommandée en cas de réémergence de la variole. Nous avons ainsi démontré pour la première fois qu’une association du cidofovir avec chacun des trois siRNA sélectionnés avait un effet synergique contre la propagation du VACV in vitro. De plus, l’activité antivirale des trois siRNA a étéévaluée contre cinq souches du VACV connues pour être résistantes au cidofovir, et à l’un de ses dérivés diaminopurique, HPMPDAP, du fait de la présence de mutations dans le gène codant l’ADN polymérase virale (E9L). Enfin, nous avons développé un siRNA en tant qu’outil expérimental afin d’étudier le mécanisme d’action de la molécule anti-orthopoxvirus, ST-246. Un siRNA, siF13L, dirigé contre la protéine virale F13, cible de ST-246, nous a permis de confirmer que l’activité antivirale de la molécule ST-246 était dépendante du mode de propagation de l’orthopoxvirus ciblé. Ces travaux démontrent l’efficacité des siRNA contre la réplication virale des orthopoxvirus in vitro et suggèrent de poursuivre leur développement in vivo en tant qu’outil thérapeutique ou prophylactique pour traiter les infections par poxvirus
The potential release of the etiological agent of smallpox, Variola virus, by bioterrorists, has prompted renewed interest in the development of new therapeutic molecules that inhibit poxvirus replication. Here we report the use of the RNA interference technology as a sequence-specific inhibitory approach against orthopoxvirus replication in vitro and in vivo. We have assessed the antiviral activities of several siRNAs targeting different genes that are essential for viral replication of vaccinia virus (VACV). Three siRNAs have been selected : siD5R-2, siB1R-2 and siG7L-1 designed to target, respectively, the D5R gene encoding the DNA-independant nucleoside triphosphatase, the essential viral gene B1R (i. E. , protein kinase) and the G7L gene encoding the protein G7 involved in virus morphogenesis. Each siRNA led to a significant decrease of VACV, cowpox virus (CPXV) and monkeypox virus (MPXV) replication (i. E. , up to 90%) in different cell lines. Our results have also demonstrated the specificity of the antiviral effect of each siRNA: they only knocked down the transcripts of the targeted genes, as shown by real time RT-PCR, and they did not induce any interferon response. Moreover, the antiviral potencies of these three siRNAs, following several routes of administration (i. E. , intranasal, intratracheal, intravenous or topical), have been investigated in vivo in a mouse model of orthopoxvirus infection. To date, cidofovir (Vistide®) is permitted for use as an emergency treatment in the case of smallpox outbreak. Thus, for the first time, we demonstrated the synergistic effect of cidofovir combined with each siRNA against VACV growth in cell culture. Moreover, we evaluated the antiviral potencies of these siRNAs against five vaccinia virus strains bearing mutations in the viral DNA polymerase gene (E9L), which are know to confer resistance to cidofovir and to one of its derivative, HPMPDAP. We finally developed a siRNA as an experimental tool to investigate the mechanism of action of the novel anti-orthopoxvirus compound ST-246. A siRNA (siF13L) designed to silence the F13L gene encoding the viral F13 protein, target of ST-246, confirmed our previous hypothesis: orthopoxviruses exhibit different levels of sensitivity to ST-246 due to their way of propagation. Our findings demonstrate the anti-orthopoxvirus potency of siRNAs and suggest to pursue their development in vivo as therapeutics for the treatment of poxvirus infections
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Duraffour, Sophie. "Utilisation de différents orthopoxvirus pour le développement de modèles substitutifs du virus de la variole afin d'évaluer l'activité antivirale". Aix-Marseille 2, 2008. http://www.theses.fr/2008AIX20663.

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A l’heure actuelle, le risque de réémergence de la variole n’est pas négligeable. Bien qu’une vaccination antivariolique efficace soit disponible en France, son utilisation reste contre-indiquée chez de nombreux sujets et notamment chez les individus immunodéprimés ou atopiques. Afin de traiter les infections à poxvirus, les recherches se sont orientées vers la sélection et la caractérisation de molécules antivirales actives et non toxiques. Dans cette thématique, nous avons développé trois types de recherches qui sont : (i) la caractérisation enzymatique de la protéine uracile ADN glycosylase du virus monkeypox, essentielle à la réplication virale et donc cible potentielle d’un traitement antiviral; (ii) le développement d’un modèle substitutif du virus de la variole, les modèles in vitro, ex vivo et in vivo du virus camelpox ; et enfin (iii) l’étude du mode d’action de la molécule ST-246 contre trois Orthopoxvirus, les virus de la vaccine, cowpox et camelpox
The intentional release of smallpox by bioterrorists is considered to be a significant threat. Although effective smallpox vaccines are available, adverse events to vaccination particularly in immunosupressed individuals can be life threatening. Thus, researches in the field of highly potent antiviral against poxviruses have been intensified. Here we report the use and the development of surrogate models of variola virus, using several related Orthopoxviruses, to study anti-poxviral compounds. We (i) characterized the DNA repair protein uracil-DNA glycosylase of monkeypox virus, which is essential for orthopoxvirus replication and thus its inhibition is a rational therapeutic strategy, (ii) developed in vitro, ex vivo and in vivo surrogate model of variola virus by using its closest known related virus, camelpox virus; and (iii) investigated the mode of action of a novel anti-orthopoxvirus molecule, ST-246, against three Orthopoxviruses, vaccinia, cowpox and camelpox viruses
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Massai, Veronica. "Medicina e potere : Angelo Gatti e l'inoculazione del vaiolo (1724-1798)". Doctoral thesis, Paris, EPHE, 2014. http://www.theses.fr/2014EPHE4035.

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Le nom du médecin toscan Angelo Gatti a été indissolublement lié à la pratique et à la promotion de l'inoculation de la variole. Avant les découvertes de Jenner sur la vaccine, cette méthode préventive était la seule apte à prévenir une maladie endémique et potentiellement mortelle. Dans la seconde moitié du XVIIIe siècle l'inoculation de la variole devint une technique très débattue non seulement au niveau scientifique mais politique, culturel et social aussi. Gatti arriva à Paris en 1760 et ce fut en France qu'il connut la célébrité grâce à deux œuvres : les Réflexions sur les préjugés qui s'opposent au progrès et à la perfection de l'inoculation (1764) et les Nouvelles réflexions sur la pratique de l'inoculation (1767). Issu d'un milieu social modeste et périphérique, Gatti réussit à créer un réseau de connaissances et amitiés avec des figures très importantes du panorama scientifique, sociale et polique en France et en Italie : ce réseau favorisa son succès professionnel et personnel et lui permit de rejoindre une position sociale très prestigieuse. Le projet de ma thèse a été celui de suivre le parcours de Gatti du Grand-Duché de Toscane sous la Régence, passant par la France des dernières années de Louis XV, pour continuer par le retour en Italie du médecin d'abord en Toscane sous Pierre Léopold et après à Naples sous Ferdinand IV et Marie Caroline. La reconstruction biographique a été conduite afin de réaliser une étude interdisciplinaire qui permette d'analyser les contextes différents dans lesquels Gatti a joué un rôle de premier plan et démontrer finalement à quel point médecine et pouvoir puissent être étroitement liés
The name of the tuscan physician Angelo Gatti has been closely linked to the practice and promotion of the inoculation for smallpox. Before Jenner discoveries about vaccine, this medical technique was the only way to prevent an endemic and deadly disease like smallpox. In the second half of the XVIIIth century the inoculation for smallpox became a discussed practice, able to involved in the debate not only the scientific community but also the social and political milieu. Gatti arrived in Paris in 1760 where he became famous thanks to his masterpieces: the Réflexions sur les préjugés qui s'opposent au progrès et à la perfection de l'inoculation (1764) and the Nouvelles réflexions sur la pratique de l'inoculation (1767). Coming from a modest and peripheral social background, Gatti was able to create an important network of relationships with many leading figures of the social, political and cultural milieu both in Italy and France which favoured his personal and professional success and led him to obtain relevant positions, more and more prestigious. The draft of my thesis has been conceived in order to follow Gatti's journey from the Grand Duchy of Tuscany under the Regency, passing by the France of the last years of King Louis XV, to continue through the Gatti's homecoming to Tuscany under the Grand Duke Peter Leopold to arrive at the Borbonian Court of Ferdinand IV and Mary Caroline in Naples. The biographical reconstruction has been led in order to assume an interdisciplinary study view, which allow to analyse the different contexts where Angelo Gatti played a leading role and finally to show how medecine and power can be linked one another
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Chabot, Line. "Le Conseil d'hygiène de la Province de Québec et la lutte contre la variole au Québec : l'épidémie de 1901-1902 et le cas du Saguenay-Lac-Saint-Jean". Master's thesis, Université Laval, 2001. http://hdl.handle.net/20.500.11794/28568.

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Rembert, Audrey. "Les vaccins antivarioliques : pathogénicité-innocuité, immunogénicité humorale et cellulaire, protection". Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20707.

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La variole, éradiquée en 1980, a représenté l’un des plus grands fléaux. Le risque de réémergence du virus de la variole rend nécessaire l’évaluation de nouveaux vaccins. Le but de notre étude était d’étudier les facteurs immunitaires essentiels à la résistance naturelle contre les orthopoxvirus et d’évaluer de nouveaux vaccins antivarioliques. La caractérisation du modèle d’infection souris/cowpox virus nous a permis de constater que la protection de la souris était due à l’ensemble des réponses immunitaires spécifiques. Un vaccin de 2ème génération (2G) et trois souches de vaccines non réplicatives (3G) ont été évaluées dans notre modèle d’infection. Le vaccin de 2G a montré la même efficacité vaccinale que le vaccin traditionnel de référence. Parmi les trois vaccins de 3G, seule la souche MVA a induit chez la souris une protection similaire au vaccin traditionnel à long terme après un rappel. Cependant, son immunogénicité induite à long terme reste inférieure au vaccin traditionnel
Smallpox, eradicated in 1980, was one of the most dreaded infectious diseases. The threat of re-emerging variola virus induced the evaluation of new smallpox vaccines. The aim of our study was to determine immune factors induced in natural protection against orthopoxviruses and to assess new smallpox vaccines. The characterisation of the mice/cowpoxvirus rodent-like model had put in evidence the important role of all the component of the specific immune system in natural protection of mice. A second generation vaccine (2G) and tree non replicative vaccinia virus strains (3G) was evaluated in our model. The 2G smallpox vaccine showed similar vaccine efficacy than the traditional vaccine. Among the different 3G vaccines assessed, the MVA strain was the only vaccine candidate inducing a similar long-term protection than the traditional vaccine but only after a vaccine boost. However, the long-term induced MVA immunogenicity was inferior to this induced by the traditional smallpox vaccine
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Livros sobre o assunto "Varioline"

1

Saluzzo, Jean-François. La variole. Paris: Presses universitaires de France, 2004.

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2

William, Osler. Clinical notes on small-pox: I. The initial rashes : II. Hæmorrhagic small-pox : III. A form of hæmorrhagic small-pox. [Montreal?: s.n., 1986.

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3

Osler, William. Clinical notes on small-pox: I.--The initial rashes; II.--Hæmorrhagic small-pox; III.--A form of hæmorrhagic small-pox. [Montreal?: s.n., 1986.

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4

Chastel, Claude. Histoire des virus: De la variole au SIDA. Paris: Editions Boubée, 1992.

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5

Jours de tourmente: Montréal au temps de la variole : roman. Montréal, Québec: VLB éditeur, 2010.

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6

Rannou, Pierre. Jean Baptiste Rouilliard et la variole à Longueuil, 1885-1886. Longueuil, QC: Editions Chantal Déragon, 2002.

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7

La longue traque de la variole: Les pionniers de la médecine préventive. Paris: Libr. académique Perrin, 1986.

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8

Adami, J. George. The centenary of vaccination, May 14, 1796. [S.l: s.n., 1986.

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9

Darmon, Pierre. La variole, les nobles et les princes: La petite vérole mortelle de Louis XV : 1774. Bruxelles: Editions Complexe, 1989.

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10

Ce bon docteur Jenner: Grâce à la première vaccination (14 mai 1796), il délivra le monde du fléau de la variole (9 décembre 1979) : la première (et la seule) éradication d'une maladie infectieuse humaine. Paris: J. Lyon, 1997.

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Capítulos de livros sobre o assunto "Varioline"

1

De Meyer, Hans, Bernard De Baets e Tarad Jwaid. "On a Class of Variolinear Copulas". In Communications in Computer and Information Science, 171–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31715-6_19.

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2

Gutt, C. N., J. M. Daume, V. Paolucci e A. Encke. "Erste Erfahrungen mit dem modularen Retraktionssystem (VarioLift) für die laparoskopische Chirurgie ohne Pneumoperitoneum". In Klinik und Forschung in der Chirurgie unter dem Aspekt von Effizienz und Ökonomie, 1238–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60881-0_313.

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3

"variolite". In Dictionary Geotechnical Engineering/Wörterbuch GeoTechnik, 1477. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41714-6_220182.

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"Variolith m". In Wörterbuch GeoTechnik/Dictionary Geotechnical Engineering, 1201. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-33335-4_220031.

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5

Bruneel, Claude. "L’inoculation de la variole en Belgique au xviiie siècle". In Enfance, assistance et religion, 219–38. LARHRA, 2006. http://dx.doi.org/10.4000/books.larhra.1239.

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6

Brown, James Robert. "L’éradication de la variole : leçons pour l’épistémologie et la politique". In Science, philosophie, société, 41–59. Presses universitaires de Franche-Comté, 2017. http://dx.doi.org/10.4000/books.pufc.13587.

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7

Roy, Réal. "Leçons à tirer du refus de l’inoculation variolique : premiers débats entre scientifiques et évolution de la tendance au refus de la vaccination". In La santé publique à une ère marquée par le doute : origines religieuses et culturelles de l’hésitation des Canadiens face à la vaccination, 100–115. Éditions de l'Université de Sherbrooke, 2019. http://dx.doi.org/10.17118/11143/16029.

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Trabalhos de conferências sobre o assunto "Varioline"

1

Kery, Mary Beth, Amber Horvath e Brad Myers. "Variolite". In CHI '17: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3025453.3025626.

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