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Artigos de revistas sobre o tema "Yuan lin yi shu"

Autor: Grafiati

Publicado: 25 de julho de 2024

Última modificação: 31 de julho de 2025

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1

Mu, Xian-Yun, Xue-Li Shen, Yuan-Mi Wu, et al. "Plastid phylogenomic study of grape species and its implications for evolutionary study and conservation of Vitis." Phytotaxa 364, no. 1 (2018): 71–80. https://doi.org/10.11646/phytotaxa.364.1.4.

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Mu, Xian-Yun, Shen, Xue-Li, Wu, Yuan-Mi, Zhu, Yi-Xuan, Dong, Shu-Bin, Xia, Xiao-Fei, Lin, Qin- Wen, Fan, Pei-Ge, Liu, Yu-Lin, Zhang, Zhi-Xiang (2018): Plastid phylogenomic study of grape species and its implications for evolutionary study and conservation of Vitis. Phytotaxa 364 (1): 71-80, DOI: 10.11646/phytotaxa.364.1.4, URL: http://dx.doi.org/10.11646/phytotaxa.364.1.4

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2

Huang, Dong-Dong, Chen-Yang Shen, Gui-Ying Huang, et al. "A new species of Isonychia Eaton, 1871 (Ephemeroptera: Isonychiidae) from Taishun, China based on morphological characteristics and COX1 gene." Zootaxa 5437, no. 4 (2024): 537–48. https://doi.org/10.11646/zootaxa.5437.4.6.

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Huang, Dong-Dong, Shen, Chen-Yang, Huang, Gui-Ying, Ye, Lin-Yu, Wu, Hui-Yuan, Zhang, Shu-Sheng, Cheng, Hong-Yi (2024): A new species of Isonychia Eaton, 1871 (Ephemeroptera: Isonychiidae) from Taishun, China based on morphological characteristics and COX1 gene. Zootaxa 5437 (4): 537-548, DOI: 10.11646/zootaxa.5437.4.6, URL: http://dx.doi.org/10.11646/zootaxa.5437.4.6

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3

Liu, Yen-Lin, Yin-Ju Chen, Shu-Huey Chen, et al. "Abstract 6723: Application of in vitro drug screening of circulating tumor cells in pediatric glioma therapy." Cancer Research 83, no. 7_Supplement (2023): 6723. http://dx.doi.org/10.1158/1538-7445.am2023-6723.

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Abstract Twenty-one gliomas in patients aged 0-21 years were evaluated for drug sensitivity by ex vivo expanded circulating tumor cells (CTC). The results were correlated with clinical outcomes. Venous blood samples were obtained prior to drug treatment. Peripheral blood mononuclear cells were processed in a 3D cell culture system (EVA Select™, Cancer Free Biotech Ltd., Taipei, Taiwan) and cultured for 3 weeks. Expanded CTCs were successfully cultured into organoids from 18 out of 21 patients and were analyzed for ATP abundance. Staining with CD45, a marker for blood cells, and pancytokeratin,

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Yu, Jhang-Sian, Ming-Chin Ko, Chia-Hung Lin та ін. "Abstract 3479: iPSC-derived γδT with novel combinatorial KO demonstrated significant anti-tumor activity and extended longevity without cytokine support". Cancer Research 85, № 8_Supplement_1 (2025): 3479. https://doi.org/10.1158/1538-7445.am2025-3479.

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Abstract Induced pluripotent stem cell (iPSC)-derived cell treatment offers several competitive benefits, including consistency, homogeneity and unlimited dosage, in contrast to autologous and allogeneic donor-derived cell therapies. These attributes improve affordability and accessibility of medicines worldwide. Noteworthy, the effectiveness of T cell therapy is constrained by factors such as cell potency and persistence. Our research on iPSC-derived gamma-delta T (γδT) cells has identified a novel combinatorial KO to overcome these challenges. IL-2 administration has been approved by FDA for

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5

Peng, Cai-Xia, Ke-Yuan Dai, Yuan-Qiu Li, Yi-Hua Tong, and Chun-Rui Lin. "Aspidistra shimentaiensis (Asparagaceae), a new species from Guangdong, China." Phytotaxa 612, no. 1 (2023): 87–92. https://doi.org/10.11646/phytotaxa.612.1.7.

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Peng, Cai-Xia, Dai, Ke-Yuan, Li, Yuan-Qiu, Tong, Yi-Hua, Lin, Chun-Rui (2023): Aspidistra shimentaiensis (Asparagaceae), a new species from Guangdong, China. Phytotaxa 612 (1): 87-92, DOI: 10.11646/phytotaxa.612.1.7, URL: http://dx.doi.org/10.11646/phytotaxa.612.1.7

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6

Yao, Yanbo. "Collaborative translation as an instrument for creating Uncle Tom’s Cabin in the early twentieth century’s China." International Journal of Arts and Humanities 4, no. 1 (2023): 147–56. http://dx.doi.org/10.25082/ijah.2023.01.003.

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The reception of translations of foreign literary works can vary depending on a variety of historical, social and cultural factors. The paper endeavors to examine how the collaborative translation between an interpreter and a writer can effectively address those interrelated factors that constrain the reception of the translation of foreign literary works with a case study of Wei Yi and Lin Shu’ translation of Harriet Beacher Stowe’s Uncle Tom’s Cabin in China in the early 20th century. When translating the novel, Wei Yi and Lin Shu Wei Yi and Lin Shu combined their strengths as an interpreter

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7

Lung, Rachel. "The Oral Translator’s “Visibility”: The Chinese Translation of David Copperfield by Lin Shu and Wei Yi." TTR : traduction, terminologie, rédaction 17, no. 2 (2006): 161–84. http://dx.doi.org/10.7202/013277ar.

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Abstract An important feature in the translation history of China in the early 20th century was the collaboration between a Chinese monolingual and a Chinese bilingual in a large-scale translation of Western fiction. Such a collaboration pattern lasted for almost two decades before more Chinese bilinguals were trained in the 1920s. The partnership of Lin Shu (1852-1924) (a prominent written translator) and Wei Yi (1880-1933) (one of Lin Shu’s oral translators) lasted for 10 years, during which they translated over 40 English novels into Chinese. Through textual analyses of their co-translation

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8

Lin, Yuan-Chien, Chien-Ti Chao, Chih-Yi Chang, and Yen-Hsueh Tseng. "Taxonomic revision of Zingiber (Zingiberaceae) of Taiwan." European Journal of Taxonomy 839 (September 28, 2022): 74–102. https://doi.org/10.5852/ejt.2022.839.1933.

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Lin, Yuan-Chien, Chao, Chien-Ti, Chang, Chih-Yi, Tseng, Yen-Hsueh (2022): Taxonomic revision of Zingiber (Zingiberaceae) of Taiwan. European Journal of Taxonomy 839: 74-102, DOI: 10.5852/ejt.2022.839.1933

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9

Li, Chang, Yi Dai, Shu-Xiang Zhang, et al. "Quinoid glycosides from Forsythia suspensa." Phytochemistry 104 (August 31, 2014): 105–13. https://doi.org/10.1016/j.phytochem.2014.04.010.

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Li, Chang, Dai, Yi, Zhang, Shu-Xiang, Duan, Ying-Hui, Liu, Ming-Li, Chen, Liu-Yuan, Yao, Xin-Sheng (2014): Quinoid glycosides from Forsythia suspensa. Phytochemistry 104: 105-113, DOI: 10.1016/j.phytochem.2014.04.010, URL: http://dx.doi.org/10.1016/j.phytochem.2014.04.010

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10

Zhu, Yao, Yi-Jian Guan, Qian-Zheng Chen, et al. "Pentacyclic Triterpenes from the resin of Liquidambar formosana have anti-angiogenic properties." Phytochemistry 184 (April 30, 2021): 1–9. https://doi.org/10.1016/j.phytochem.2021.112676.

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Zhu, Yao, Guan, Yi-Jian, Chen, Qian-Zheng, Yuan, Liao-Heng, Xu, Qian-Qian, Zhou, Mei-Lin, Liu, Hui, Lin, Wei, Zhang, Zong-Duan, Zhou, Zhong-Lou, Dong, Jian-Yong (2021): Pentacyclic Triterpenes from the resin of Liquidambar formosana have anti-angiogenic properties. Phytochemistry (112676) 184: 1-9, DOI: 10.1016/j.phytochem.2021.112676, URL: http://dx.doi.org/10.1016/j.phytochem.2021.112676

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Dong, Shu-Peng, Yi Huang, and Zu-Lin Ning. "Aspidistra yangchunensis (Asparagaceae), a new species from Guangdong, China." Phytotaxa 647, no. 1 (2024): 115–20. https://doi.org/10.11646/phytotaxa.647.1.6.

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Dong, Shu-Peng, Huang, Yi, Ning, Zu-Lin (2024): Aspidistra yangchunensis (Asparagaceae), a new species from Guangdong, China. Phytotaxa 647 (1): 115-120, DOI: 10.11646/phytotaxa.647.1.6, URL: http://dx.doi.org/10.11646/phytotaxa.647.1.6

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Yi, Si-Yong, Ya Huang, Hong-Yuan Chen, Xiao-Xu Zhou, and Chun-Rui Lin. "Aspidistra jiangjinensis (Asparagaceae), a new species from Chongqing, China." Phytotaxa 437, no. 3 (2020): 164–68. https://doi.org/10.11646/phytotaxa.437.3.6.

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Yi, Si-Yong, Huang, Ya, Chen, Hong-Yuan, Zhou, Xiao-Xu, Lin, Chun-Rui (2020): Aspidistra jiangjinensis (Asparagaceae), a new species from Chongqing, China. Phytotaxa 437 (3): 164-168, DOI: 10.11646/phytotaxa.437.3.6, URL: http://dx.doi.org/10.11646/phytotaxa.437.3.6

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13

Xie, Dan, Meng-Hua Zhang, Shu-Peng Dong, Yuan-Long Gao, Dai-Gui Zhang, and Zu-Lin Ning. "Salvia tainingensis, a neglected new species of Lamiaceae from Fujian Province, China." Phytotaxa 669, no. 2 (2024): 150–58. https://doi.org/10.11646/phytotaxa.669.2.7.

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Xie, Dan, Zhang, Meng-Hua, Dong, Shu-Peng, Gao, Yuan-Long, Zhang, Dai-Gui, Ning, Zu-Lin (2024): Salvia tainingensis, a neglected new species of Lamiaceae from Fujian Province, China. Phytotaxa 669 (2): 150-158, DOI: 10.11646/phytotaxa.669.2.7, URL: https://doi.org/10.11646/phytotaxa.669.2.7

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14

Lv, Ye, Yang Sun, Di Dai, et al. "Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population." Zoological Studies 63, no. 44 (2024): 141–49. https://doi.org/10.6620/ZS.2024.63-44.

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Lv, Ye, Sun, Yang, Dai, Di, Luan, Zhi-Lin, Lu, He-Yuan, Li, Cheng-Jie, Luo, Yi-Yang (2024): Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population. Zoological Studies 63 (44): 141-149, DOI: 10.6620/ZS.2024.63-44, URL: http://dx.doi.org/10.1097/YPG.0000000000000262

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15

Hua, Tsen, Hui-Yi Li, Cheng-Lung Tsai, Wing Wei Wang, Chao-Yuan Lin, and Wen-Bin Yeh. "Composition and Dynamics of Hexapod Communities on Yushan Bamboo () in the Subtropical Montane Areas of Taiwan." Zoological Studies 62, no. 9 (2023): 1–12. https://doi.org/10.6620/ZS.2023.62-09.

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Hua, Tsen, Li, Hui-Yi, Tsai, Cheng-Lung, Wang, Wing Wei, Lin, Chao-Yuan, Yeh, Wen-Bin (2023): Composition and Dynamics of Hexapod Communities on Yushan Bamboo () in the Subtropical Montane Areas of Taiwan. Zoological Studies 62 (9): 1-12, DOI: 10.6620/ZS.2023.62-09, URL: http://dx.doi.org/10.6620/ZS.2023.62-09

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16

Li, Shun-Ji, Ju-Ping Huang, Yang-Yang Chang, et al. "Development of Microplitis similis (Hymenoptera: Braconidae) on two candidate host species, Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae)." Florida Entomologist 98, no. 2 (2015): 736. https://doi.org/10.1653/024.098.0250.

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Li, Shun-Ji, Huang, Ju-Ping, Chang, Yang-Yang, Quan, Si-Yuan, Yi, Wen-Ting, Chen, Zi- Shu, Liu, Shuang-Qing, Cheng, Xiao-Wen, Huang, Guo-Hua (2015): Development of Microplitis similis (Hymenoptera: Braconidae) on two candidate host species, Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae). Florida Entomologist 98 (2): 736, DOI: 10.1653/024.098.0250, URL: http://www.bioone.org/doi/10.1653/024.098.0250

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17

LIN, JIAN-ZHEN, and ZHI-QIANG ZHANG. "Bdelloidea of China: a review of progress on systematics and biology, with a checklist of species." Zoosymposia 4, no. 1 (2010): 42–50. http://dx.doi.org/10.11646/zoosymposia.4.1.3.

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This paper reviews the research on the systematics and biology of the superfamily Bdelloidea in China, with an updated checklist of 48 species belonging to 16 genera in the family Cunaxidae and 26 species belonging to nine genera in the family Bdellidae. Important contributions to the Chinese fauna of the Bdellidae were made by Tseng Yi-Hsiung (Taiwan), Hong Mei (former with Fudan University in Shanghai) and Lin Jian-Zhen (and colleagues in Fujian Academy of Agricultural Sciences, Fuzhou), and those to the Cunaxidae by Tseng Yi-Hsiung, Li Long-Shu (and colleagues in Southwest University, Chong

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18

Su, Research Article Chun-Jui, Wen-Ting Ju, Yi-Min Chen, et al. "Palmitic acid and long-chain polyunsaturated fatty acids dominate in mycelia of mangrove Halophytophthora and Salispina species in Taiwan." Botanica Marina 64, no. 6 (2021): 503–18. https://doi.org/10.1515/bot-2021-0030.

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Su, Research Article Chun-Jui, Ju, Wen-Ting, Chen, Yi-Min, Chiang, Michael W.L., Hsieh, Sung-Yuan, Lin, Han-Jia, Jones, E.B. Gareth, Pang, Ka-Lai (2021): Palmitic acid and long-chain polyunsaturated fatty acids dominate in mycelia of mangrove Halophytophthora and Salispina species in Taiwan. Botanica Marina (Warsaw, Poland) 64 (6): 503-518, DOI: 10.1515/bot-2021-0030, URL: https://doi.org/10.1515/bot-2021-0030

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19

Hsu, Yung-Jung. "(Invited) Core@Shell and Yolk@Shell Nanocrystals for Hydrogen Production." ECS Meeting Abstracts MA2024-02, no. 59 (2024): 3929. https://doi.org/10.1149/ma2024-02593929mtgabs.

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With the inherently high degree of complexity, heterostructures composed of two or more materials joined in unique architectures may exhibit superior synergetic properties that are difficult or impossible to acquire from their individual constituents. For semiconductor heterostructures, the relative band alignment of the constituents promotes effective charge separation to bring them desirable properties for photocatalysis applications. Among the different types of heterostructures, core@shell and yolk@shell nanocrystals have received particular interest due to their fascinating properties. Se

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Lee, Chuan-Chun, Wan-Rong Wu, Liang-Chih Liu, et al. "Abstract 6051: Opposing function of USP5 in MRE11 endonuclease activity to evade anti-tumor immunity." Cancer Research 85, no. 8_Supplement_1 (2025): 6051. https://doi.org/10.1158/1538-7445.am2025-6051.

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Abstract Proliferating cancer cells frequently encounter replication stress, which is known to generate abnormal cytosolic DNA and trigger anti-tumor immune responses. Thus, the ability to evade immune surveillance is critical for the development and progression of malignant tumors for which the mechanisms are not fully understood. The MRE11 nuclease, essential for maintaining DNA integrity during cell proliferation, plays important roles in processing stalled replication forks during replication stress. This process produces single-stranded DNA (ssDNA) intermediates which activate the cGAS-ST

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21

Chao, Xue-lin, Shu-zhen Jiang, Jian-wen Xiong, et al. "Erratum to: Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics." Current Medical Science 40, no. 5 (2020): 997. http://dx.doi.org/10.1007/s11596-020-2256-3.

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The article “Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics”, written by Xue-lin CHAO, Shu-zhen JIANG, Jian-wen XIONG, Jin-qiong ZHAN, Bo WEI, Chun-nuan CHEN, Yuan-jian YANG was originally published electronically on the publisher’s internet portal on June 2020 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International

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Du, Xue, and Lingsheng Shi. "Trees with given maximum degree minimizing the spectral radius." Electronic Journal of Linear Algebra 31 (February 5, 2016): 335–61. http://dx.doi.org/10.13001/1081-3810.3323.

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The spectral radius of a graph is the largest eigenvalue of the adjacency matrix of the graph. Let $T^*(n,\Delta ,l)$ be the tree which minimizes the spectral radius of all trees of order $n$ with exactly $l$ vertices of maximum degree $\Delta $. In this paper, $T^*(n,\Delta ,l)$ is determined for $\Delta =3$, and for $l\le 3$ and $n$ large enough. It is proven that for sufficiently large $n$, $T^*(n,3,l)$ is a caterpillar with (almost) uniformly distributed legs, $T^*(n,\Delta ,2)$ is a dumbbell, and $T^*(n,\Delta ,3)$ is a tree consisting of three distinct stars of order $\Delta $ connected

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Chien, Po-Chen, Rong-Hsuan Wang, Pin-Ru Chen, et al. "Abstract 437: Hydrogen sulfide switches the glucose metabolism through sulfhydration on pyruvate kinase M2." Cancer Research 84, no. 6_Supplement (2024): 437. http://dx.doi.org/10.1158/1538-7445.am2024-437.

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Abstract Cancer cells reprogram their glucose metabolism from oxidative phosphorylation to aerobic glycolysis. This metabolic transformation is partly based on the activity alterations of a rate limiting enzyme known as the pyruvate kinase M2 (PKM2), which is responsible for the conversion of phosphoenolpyruvate (PEP) into pyruvate. Attributed to its critical regulatory role. PKM2 is recognized as the pivotal enzyme in cancer glucose metabolism By reducing the enzyme activity of PKM2, cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid

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Tsai, Hsing-Chen, Yi-Chieh Wu, Yu-Ting Lee, et al. "Abstract 4838: Epigenetic modulation of polyamine biosynthetic pathways rectifies T cell dysfunction to enhance anti-tumor immunity in lung cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 4838. https://doi.org/10.1158/1538-7445.am2025-4838.

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T cell exhaustion, a dysfunctional state caused by prolonged antigen exposure, presents a major challenge in cancer immunotherapy. While immune checkpoint inhibitors show therapeutic promise, they fail to rejuvenate T cells in a terminally exhaustion state, potentially due to epigenetic barriers. We hypothesized that targeting epigenetic regulators may provide novel therapeutic strategies to overcome these barriers, thereby rescuing terminally exhausted T cells. In this project, we used malignant pleural effusions from advanced lung cancer patients as a source of primary exhausted T cells. Thr

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Lee, Soon-ok. "A Study on Aesthetics of Confucian & Taoistic Calligraphic Theory in East Han." Korean Society of Calligraphy 43 (September 28, 2023): 77–98. http://dx.doi.org/10.19077/tsoc.2023.43.4.

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An overview of the history of Chinese calligraphy shows that many people in Tang Dynasty such as Zang Huaiguan(張懷瓘), Yu Shinan(虞世南), expressed very precise and philosophical views on calligraphy. Yet, there have already been discussions related to calligraphy in thr Eastern Han Dynasty before such in-depth views of calligraphy in Tang Dynasty. Yang Xiong(揚雄) has already clarified the espression of the mind of calligraphy by saying that 'Shu(書)〔originally a book, but later understood as a calligraphy〕is picture of the mind, which is composed of characters written with a brush. however, people t

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Chen, Pie-Che, Guan-Ling Lin, Hon-Yi Lin, et al. "Abstract 2243: Cyproheptadine exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma." Cancer Research 83, no. 7_Supplement (2023): 2243. http://dx.doi.org/10.1158/1538-7445.am2023-2243.

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Abstract Urothelial carcinoma (UC) is the second most common malignancy of the urinary system with high rate of recurrence, UC patients therefore needed to be treated with surgery followed by chemotherapy. Development of novel therapeutics with minimal side-effect is an urgent issue. Our previous study showed that cyproheptadine (CPH), an anti-histamine, exhibited antitumor activity in UC in vitro and in an xenograft model. In this study, we performed RNA-Seq to examine genes that are differentially expressed after treatment with CPH in UC cells. Our result showed that several genes, including

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Cheng, Kai-Lin, Chih-I. Chen, Shu-Han Yu, et al. "Abstract 285: Targeting TXNDC5 in stromal fibroblasts resolves desmoplasia and resistance to immune checkpoint blockade in mesenchymal-type colorectal cancer." Cancer Research 84, no. 6_Supplement (2024): 285. http://dx.doi.org/10.1158/1538-7445.am2024-285.

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Abstract Objectives: Mesenchymal-type colorectal cancer (CRC), characterized by strong stromal infiltration and immune tolerance, resists immune checkpoint blockade and has poor outcomes. Cancer-associated fibroblasts (CAFs), abundant in tumor stroma, actively remodel the extracellular matrix (ECM), modulate immune evasion, and drive tumor progression. We have recently identified thioredoxin domain-containing protein 5 (TXNDC5), a protein disulfide isomerase (PDI), as a critical mediator of fibroblast activation and ECM remodeling in organ fibrosis. We hypothesized that TXNDC5 could contribute

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Jin, Yong-zhen. "On the Influence of Tao Yuan-ming on the Poetry Creation of Joseon Scholar of the 16th Century－Take Lin Yi-ling for Example－." Journal of Chinese Studies 90 (November 30, 2019): 173–90. http://dx.doi.org/10.36493/jcs.90.6.

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Liu, Chun-Yu, Chi-Cheng Huang, Yi-Fang Tsai, et al. "Abstract P6-01-45: Correlation of an immune-related 8-gene panel with the efficacy of neoadjuvant chemotherapy for breast cancer." Cancer Research 83, no. 5_Supplement (2023): P6–01–45—P6–01–45. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-01-45.

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Abstract Introduction: Neoadjuvant chemotherapy, one of systemic treatment of breast cancer, is employed for downstaging of inoperable tumor. Pathological complete response (pCR) after neoadjuvant chemotherapy is associated with good prognosis for breast cancer. The critical role of anti-tumor immune responses in conventional chemotherapy and targeted therapy has been reported. However, the pCR-associated immune genes are still ambiguous. Materials and Methods: Thirty-seven primary breast cancer patients receiving neoadjuvant chemotherapy as the first-line treatment for breast cancer were recr

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Liu, Chun-Yu, Chi-Cheng Huang, Ji-Lin Chen, et al. "Abstract 2271: Characteristics of peripheral blood T cell receptor repertoire and correlation with response to chemotherapy in patients with breast cancer." Cancer Research 83, no. 7_Supplement (2023): 2271. http://dx.doi.org/10.1158/1538-7445.am2023-2271.

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Abstract Purpose: The success of immune checkpoint inhibitors therapy in triple negative breast cancer highlights the potential immunogenic characteristics of breast cancer. Increasing evidence have suggested that conventional chemotherapy can exert anti-cancer activity through various immune-based mechanisms. T cell receptor (TCR) diversity is crucial for immune responses and TCR repertoire has been reported acting as predictive and prognostic markers for cancer outcome. Here, we reported the TCR repertoire profiling in breast cancer and its association with chemotherapy and treatment respons

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Guimin, Wang. "6. A Tentative Description of the Civilization of the Middle Period of Late Shang." Early China 9, S1 (1986): 11–14. http://dx.doi.org/10.1017/s0362502800002935.

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ABSTRACTThe late Shang represents a peak in bronze culture, and was the culmination of a long period of development. The words of the Duke of Zhou in the “Wu yi” chapter of the Shang shu that “The kings who arose after [Zu Jia], during their (whole) life enjoyed ease …. After this there were none who had any chance of reaching a high age…” is not sufficient to be relied upon. Nor is it appropriate to evaluate the entirety of Late Shang history solely on the basis of the large number of oracle bones from the reign of Wu Ding. The primary purpose of this paper is to demonstrate, through an analy

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Jia, Meng. "“Circulations” and Self-Transcendence: A Comparative Study of Emerson and Zhuangzi." Religions 16, no. 6 (2025): 702. https://doi.org/10.3390/rel16060702.

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In this article, I begin with the topic of “circulations”, conducting a comparative analysis of the similarities and differences in Emerson’s and Zhuangzi’s philosophies regarding “circulations” as the mode of cosmic generation and operation, as well as the relationship between “circulations” and self-transcendence. Furthermore, I explore the practical paths to achieve self-transcendence via circulations based on these two aspects. Specifically, both Emerson and Zhuangzi regard “circulations” as the fundamental way of cosmic generation and operation. However, Emerson emphasizes the directional

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Wang, Shi-Jia, Feng Xin, Wei Zhang, et al. "Abstract P2-05-10: Depression and anxiety in patients with breast cancer receiving radiotherapy: A prospective longitudinal study." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–05–10—P2–05–10. https://doi.org/10.1158/1557-3265.sabcs24-p2-05-10.

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Abstract Purpose: To evaluate the prevalence and changes in depression and anxiety symptoms from pre-radiotherapy (RT) to 6 months post-RT in patients with breast cancer receiving RT; and to identify risk factors for depression and anxiety at baseline and for an increase of depression and anxiety over time. Methods: This prospective, longitudinal observational study was conducted in China between August 2022 and August 2023. Depression and anxiety symptoms were measured by the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder (GAD-7) before and during RT,

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Wang, Nan, Zhuonan Wang та Hongyu Zheng. "Round Heaven and Square Earth, the Unity of the Pagoda and Statues—A Study on the Geometric Proportions of the Architectural Space, Statues, and Murals in Ying Xian Fogong Si Shijia Ta 應縣佛宮寺釋迦塔 (Sakyamuni Pagoda of Fogong Temple in Ying County)". Religions 15, № 7 (2024): 802. http://dx.doi.org/10.3390/rel15070802.

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In Ying Xian Fogong Si Shijia Ta 應縣佛宮寺釋迦塔 (Sakyamuni Pagoda of Fogong Temple in Ying County), Shanxi, there are statues set on each floor, and 26 exist in total, with six murals painted on the first floor. The pagoda was designed as a vertically rising Buddhist temple, and the interior space of each floor was customized for the statues. Based on previous research and through surveying and mapping of the architecture and statuary (including the murals on the first floor) combined with geometric design analysis, this paper proposes the following: First, there exists a clear geometric proportion

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Lin, Po-Han, Ya-Hui Chen, Chi-Maw Lin, et al. "Abstract 2220: Gut microbiome impacts the tumor microenvironment and enhances the effectiveness of anti-PD1 therapy in head and neck cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 2220. https://doi.org/10.1158/1538-7445.am2025-2220.

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Abstract Although the Food and Drug Administration has approved anti-PD1 as an effective therapy for recurrent head-and-neck squamous cell carcinoma (HNSCC), its response rate remains limited to approximately 10-30%, and the prognosis for patients is still poor. In this study, we seek to enhance the therapeutic efficacy of anti-PD1 for recurrent HNSCC. First, we compared the pathology of responders and non-responders to pembrolizumab treatment for HNSCC. Immunohistochemical staining revealed a significantly higher abundance of CD8 T cells in responders, and RNA sequencing, through Gene Set Enr

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Wang, Shi-Jia, Xin Feng, Wei Zhang, et al. "Abstract P5-11-07: A longitudinal analysis of the specific types of anxiety towards radiotherapy in patients with breast cancer before, during, and after radiotherapy." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–11–07—P5–11–07. https://doi.org/10.1158/1557-3265.sabcs24-p5-11-07.

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Abstract Backgrounds: Most patients have many concerns about radiotherapy (RT) because they know little about it. Radiotherapy Categorical Anxiety Scale (RCAS) was formulated to evaluate the specific types of anxiety among cancer patients receiving RT. This study aims to apply the RCAS to breast cancer patients in China and assess the reliability and validity of the Chinese version; and to investigate its longitudinal changes throughout treatment. Methods: This prospective, longitudinal study enrolled 504 eligible breast cancer patients receiving RT in China. Patients completed questionnaires

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Chen, I.-Chun, Ching-Hung Lin, Dwan-Ying Chang, et al. "Abstract CT141: Combination of hormone therapy, GnRH agonist, and immunotherapy enhance immune activation in premenopausal ER+/HER2- metastatic breast cancer patients: Results of biomarker analysis from a pilot phase II study." Cancer Research 83, no. 8_Supplement (2023): CT141. http://dx.doi.org/10.1158/1538-7445.am2023-ct141.

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Abstract Introduction: Immunotherapy has not been proved to be efficacious in ER+/HER2- metastatic breast cancer. Our team has reported an effective combination of exemestane, gonadotropin releasing hormone agonist, and pembrolizumab in premenopausal ER+/HER2- MBC. Here we report the updates of the final results and biomarker associates of the study. Methods: Premenopausal ER+/HER2- MBC patients who failed no more than 2 lines of hormone therapy without chemotherapy for MBC were enrolled in a tertiary medical center in Taiwan (NCT02990845). The primary endpoint was progression-free survival (P

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Chen, MeiKuang, Yuan Gao, Weiya Xia, et al. "Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance." Cancer Research 82, no. 12_Supplement (2022): 1792. http://dx.doi.org/10.1158/1538-7445.am2022-1792.

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Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi), which induce DNA damage by inhibiting PARP1 enzymatic activity and trapping PARP on the damaged DNA, are used to eliminate BRCA1/2-mutated (BRCAm) cancer. However, clinical observations suggest that BRCAm tumors develop PARPi resistance. Current strategies to overcome PARPi resistance include impeding multiple DNA repair pathways to induce excessive DNA damage. Here, we propose a novel strategy targeting oncogenic receptor tyrosine kinases to enhance PARP trapping. By developing triple-negative breast cancer (TNBC) cells with acqu

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Lin, Yuan, Theresa A. Ramelot, Simge Senyuz, et al. "Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states." Cancer Research 84, no. 6_Supplement (2024): 4388. http://dx.doi.org/10.1158/1538-7445.am2024-4388.

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Abstract RhoA is the founding member of the Ras-homology (Rho) small GTPase family and is a master regulator for multiple cell functions. Recurrent RhoA mutations have been identified in several human cancers, particularly in leukemia/lymphoma and gastric cancer. Intriguingly, both gain-of-function and loss-of-function mutations of RhoA are present, suggesting that RhoA GTPase may have a more sophisticated role in cancer and requires more rigorous investigations. Here, we have focused on two of the gain-of-function RhoA mutations identified in Adult T cell Leukemia/lymphoma (ATLL) at residue A

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Chang, Li-Hsin, Hao-Han Chang, Xin-Yi Lin, et al. "Abstract 5651: Personalized transcriptomic profiling for advanced prostate cancer: Guiding second-generation hormonal drug selection." Cancer Research 84, no. 6_Supplement (2024): 5651. http://dx.doi.org/10.1158/1538-7445.am2024-5651.

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Abstract Introduction: Second-generation hormonal drugs have demonstrated significant efficacy in extending the survival of patients with advanced prostate cancer. These drugs operate through two distinct molecular mechanisms: inhibition of androgen biosynthesis and blockade of the androgen receptor. However, due to concerns of side effects, concurrent usage of multiple drugs is not recommended. A notable challenge is the eventual development of drug resistance, rendering all second-generation hormonal therapies ineffective. Currently, there is a lack of guidelines for helping patients choose

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Bamdad, Cynthia Carol, Joanne E. Mortimer, Yuan Yuan, et al. "Abstract CT096: Phase I first-in-human MUC1* targeted autologous CAR T cells for the treatment of metastatic breast cancers." Cancer Research 84, no. 7_Supplement (2024): CT096. http://dx.doi.org/10.1158/1538-7445.am2024-ct096.

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Abstract Purpose: First-in-human Phase I study for advanced MUC1* positive breast cancer with autologous T cells engineered to express either a chimeric antigen receptor, huMNC2-CAR44 or huMNC2-CAR22, which specifically bind to a cleaved form of MUC1 (MUC1*); evaluate the safety and preliminary anti-tumor activity. Methods: MUC1* (muk 1 star) is the growth factor receptor form of MUC1, created by cleavage and release of the N-terminal portion of MUC1. The targeting antibody, huMNC2, only recognizes the conformational epitope created when MUC1 is cleaved by specific tumor-associated enzymes tha

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Chen, Shu-Mei, Hsieng-Yun Huang, Chien-Kai Wang, Yi-Yuan Yang, Sy-Jye Leu, and Ying-Ying Li. "Abstract 152: Exploring the impact of heat shock protein 90 on the antitumor efficacy and stemness in medulloblastoma cells." Cancer Research 84, no. 6_Supplement (2024): 152. http://dx.doi.org/10.1158/1538-7445.am2024-152.

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Abstract Background: Medulloblastoma (MB) is the most common children’s malignant brain tumor. Although MB can be treated with conventional chemotherapies, chemoresistance has been frequently developed and thereby hampers their therapeutic effectiveness. The preliminary reports of our research showed that some heat shock proteins have higher levels in MB cells. Among these heat shock proteins, HSP70 and HSP90 expressions are particularly high in MB CD133+ cancer stem cells (CSCs), which arouses our attention and interest. Numerous studies demonstrated that heat shock proteins are prominent in

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Lu, Shun, Zhen Zhou, Zi-Ming Li, et al. "Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors." Cancer Research 85, no. 8_Supplement_2 (2025): CT008. https://doi.org/10.1158/1538-7445.am2025-ct008.

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Abstract Background: SYS6010 is a novel ADC comprising of an anti-epidermal growth factor receptor (EGFR) humanized IgG1 monoclonal antibody conjugated to topoisomerase I inhibitor JS-1 via a cleavable glycine̶̶-glycine-phenylalanine-glycine tetrapeptide linker. Methods: This multicenter, open-label, phase 1 study evaluated the safety, tolerability and preliminary efficacy of SYS6010 in patients with advanced solid tumors who had failed or were intolerant to standard treatment. The study consisted of two parts, dose escalation, PK expansion (part 1) and dose expansion (part 2), part 1 used a 3

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Gao, Yue, Chun-Jie Liu, Hua-Yi Li, et al. "Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study." Cancer Research 82, no. 12_Supplement (2022): LB168. http://dx.doi.org/10.1158/1538-7445.am2022-lb168.

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Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2

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Shu, Yongqian, Yueyin Pan, Ping Lu, et al. "Abstract CT076: Randomized, global, phase 3 study of tislelizumab plus chemotherapy versus chemotherapy as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-306): China subgroup analysis." Cancer Research 83, no. 8_Supplement (2023): CT076. http://dx.doi.org/10.1158/1538-7445.am2023-ct076.

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Abstract Background: Tislelizumab, an anti-programmed cell death protein 1 (PD-1) antibody, + chemotherapy (chemo) demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS) vs placebo + chemo, with a manageable safety profile, as a first line (1L) treatment for patients (pts) with advanced or metastatic esophageal squamous cell carcinoma (ESCC) at interim analysis of the phase 3 RATIONALE-306 study. We report data from the China subgroup analysis. Methods: In this randomized, double-blind, global study, adults with unresectable locally advanced or

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Chen, Bo-Fang, Chi-Cheng Huang, Ling-Ming Tseng, et al. "Abstract P2-10-01: Real-world Experience with CDK4/6 Inhibitors in Hormone Receptor-Positive Metastatic and Recurrent Breast Cancer in Asian Population." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–10–01—P2–10–01. https://doi.org/10.1158/1557-3265.sabcs24-p2-10-01.

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Abstract Purpose: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy have demonstrated significant clinical benefits in progression-free and overall survival. This study investigates the outcomes associated with two kinds of CDK4/6i, palbociclib and ribociclib, in patients with hormone receptor (HR) positive metastatic and relapsed breast cancer to inform real-world evidence of treatment strategies. Methods: This retrospective study included 340 Taiwanese patients with HR-positive advanced breast cancer from the Taipei Veterans General Hospital, between 2018 and 2

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Lee, Chuan-Chun, Wan-Rong Wu, Yi-Chun Shen, et al. "Abstract 2690: The role of PCNA tyrosine phosphorylation in evading innate immune surveillance." Cancer Research 84, no. 6_Supplement (2024): 2690. http://dx.doi.org/10.1158/1538-7445.am2024-2690.

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Abstract Cancer cells are continually exposed to intrinsic and extrinsic proliferative stresses that can send the genome stability awry. The aberrant DNA metabolism, evolving through deregulated replicative growth in cancer cells, is increasingly recognized as a major mechanism bridging the crosstalk between the immune microenvironment and tumor tissue, thereby either promoting or suppressing tumor progression. However, the triggering and regulation of these mechanisms remain largely unknown. Proliferating cell nuclear antigen (PCNA) and its homologs are the evolutionarily conserved central co

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Aberin, Marvin A., Yu-Ling (Pony) Lee, Xin-Guo Hsu, et al. "Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression." Cancer Research 83, no. 7_Supplement (2023): 3646. http://dx.doi.org/10.1158/1538-7445.am2023-3646.

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Abstract Despite advancements of immunotherapy against various cancers, breast cancer still retains poor response to immune checkpoint blockade (ICB) therapy. Therefore, the identification of promising target or new strategy to enhance ICB therapy in breast cancer is crucial. Here, we uncover that the DNA-damaging potential of tamoxifen (TAM) can shape the unfavorable but ready-to-fire tumor immune microenvironment in breast cancer. We discover that a long-term TAM administration unexpectedly induces JAK/STAT signaling and Type I interferon (IFN)-stimulated gene expression to promote T-cell in

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Lee, Pony Yu-Ling, Marvin A. Aberin, Chien-Chang Shen, et al. "Abstract 5953: Reshaping the tumor microenvironment: new application of tamoxifen in triple negative breast cancer immunomodulation." Cancer Research 83, no. 7_Supplement (2023): 5953. http://dx.doi.org/10.1158/1538-7445.am2023-5953.

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Abstract Tamoxifen is a widely known estrogen receptor (ER) modulator which has been employed in adjuvant treatment of ER+ breast cancer for over 30 years. Interestingly, clinical observations reveal that tamoxifen is capable of inducing regression of some tumors lacking ER expression whereas tamoxifen is also capable of increasing host resistance against cancer in an ER-independent mechanism. These findings suggest the immunomodulatory effects of tamoxifen may be ER-independent, but little is known about the underlying mechanism and the potential clinical implication. Recently, we identified

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Yu-Ling Lee, Pony, Kun-Yuan Lin, Chao-Di Chang, et al. "Abstract 1671: Targeting histone H3K27 demethylase for anti-tumor activity: Monotherapy and combination with ceralasertib in non-small cell lung carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 1671. https://doi.org/10.1158/1538-7445.am2025-1671.

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Abstract Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung carcinoma (NSCLC) accounting for 85% of cases and associated with poor prognosis. The lysine-specific demethylase KDM6A, responsible for removing H3K27 trimethylation at gene promoters and enhancers, is frequently mutated in various cancers. While KDM6A is predominantly considered as a tumor suppressor gene, recent studies suggusted it may support oncogenic transcriptional regulation. To investigate the role of KDM6A in tumorigenesis, we utilized CRISPR-Cas9/sgRNA to knock out (KO) KDM6A in N

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