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Artigos de revistas sobre o tema "Zymosan opsonisé"

Autor: Grafiati

Publicado: 29 de março de 2025

Última modificação: 31 de julho de 2025

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1

van der Bruggen, T., P. T. Kok, J. A. Raaijmakers, J. W. Lammers, and L. Koenderman. "Cooperation between Fc gamma receptor II and complement receptor type 3 during activation of platelet-activating factor release by cytokine-primed human eosinophils." Journal of Immunology 153, no. 6 (1994): 2729–35. http://dx.doi.org/10.4049/jimmunol.153.6.2729.

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Abstract After priming with cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, or IL-5, eosinophils are stimulated potently by opsonized particles like serum-treated zymosan (STZ), resulting in activation of the respiratory burst and production of lipid mediators, such as platelet-activating factor (PAF) and leukotriene C4 (LTC4). In the present study, the role of the opsonin receptors Fc gamma RII and CR3 during both STZ-induced activation of the respiratory burst and PAF release by human eosinophils was investigated. Inhibition studies with blocking mAbs (alp

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2

Sahlin, Herman, and Håkan Nygren. "Cytotoxicity Testing of Wound-Dressing Materials." Alternatives to Laboratory Animals 29, no. 3 (2001): 269–75. http://dx.doi.org/10.1177/026119290102900319.

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A method was developed for testing the cytotoxicity of various bandage-like wound dressings and gel wound dressings. In this method, the ability of human polymor-phonuclear neutrophils (PMNs) to initiate a respiratory burst after exposure to the various wound dressings is used as a marker of cytotoxicity. Luminol-amplified chemiluminescence stimulated with opsonised zymosan or phorbol 12-myristate 13-acetate (PMA) is used to measure the degree of activation of the respiratory burst, i.e. the NADPH oxidase activity, after exposure to wound dressings. Opsonised zymosan (material from yeast cell

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3

Le Cabec, Véronique, Carine Cols, and Isabelle Maridonneau-Parini. "Nonopsonic Phagocytosis of Zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) Involves Distinct Molecular Determinants and Is or Is Not Coupled with NADPH Oxidase Activation." Infection and Immunity 68, no. 8 (2000): 4736–45. http://dx.doi.org/10.1128/iai.68.8.4736-4745.2000.

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ABSTRACT Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal transduction mechanisms operating during nonopsonic ingestion through CR3 of different microorganisms. In the present study, we used CHO cells stably transfected with CR3 to show that CR3 was able to mediate internalization of zymosan and pathogenic mycobacteria (Mycobacte

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4

Klebanoff, S. J., M. A. Vadas, J. M. Harlan, et al. "Stimulation of neutrophils by tumor necrosis factor." Journal of Immunology 136, no. 11 (1986): 4220–25. http://dx.doi.org/10.4049/jimmunol.136.11.4220.

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Abstract Human recombinant tumor necrosis factor (TNF) was shown to be a weak direct stimulus of the neutrophil respiratory burst and degranulation. The stimulation, as measured by iodination, H2O2 production, and lysozyme release, was considerably increased by the presence of unopsonized zymosan in the reaction mixture, an effect which was associated with the increased ingestion of the zymosan. TNF does not act as an opsonin but, rather, reacts with the neutrophil to increase its phagocytic activity. TNF-dependent phagocytosis, as measured indirectly by iodination, is inhibited by monoclonal

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5

ROUIS, Mustapha, Fabienne NIGON, Thomas L. EGGERMAN, H. Bryan BREWER, and M. John CHAPMAN. "Apolipoprotein E expression by human-monocyte-derived macrophages. Modulation by opsonised zymosan and cholesterol." European Journal of Biochemistry 189, no. 2 (1990): 447–53. http://dx.doi.org/10.1111/j.1432-1033.1990.tb15509.x.

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6

Nair, P. K. Raveendran, Steven J. Melnick, Ziad A. Khatib, Reshma Ramachandran, Enrique A. Escalon та Cheppail Ramachandran. "Mechanism of Immune System Activation by (1,4)-α-D-glucan Isolated from Tinospora cordifolia in Macrophages." Blood 108, № 11 (2006): 3833. http://dx.doi.org/10.1182/blood.v108.11.3833.3833.

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Abstract We have characterized and reported the immunostimulating properties of a novel polysaccharide - (1,4)-α-D-glucan (RR1)- isolated from the medicinal plant Tinospora cordifolia [23]. This novel glucan is water soluble and having (1, 4)-α-D-glycosidic linkages in the main chain and (1, 6)-α-D-glycosidic linked side chains at an interval of 6, 7 glucose units. The signaling mechanism of the novel (1,4)-a-D-glucan (RR1) was investigated in macrophages to evaluate its immunostimulating properties. When RAW264.7 macrophages were incubated with RR1 at 4°C, the novel glucan inhibited the phago

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7

Melnick, D. A., W. M. Nauseef, S. D. Markowitz, J. P. Gardner, and H. L. Malech. "Biochemical analysis and subcellular localization of a neutrophil-specific antigen, PMN-7, involved in the respiratory burst." Journal of Immunology 134, no. 5 (1985): 3346–55. http://dx.doi.org/10.4049/jimmunol.134.5.3346.

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Abstract The adherence of serum-opsonized yeast to neutrophils results in phagocytosis of these particulate stimuli and activation of the respiratory burst. Both events are mediated or modulated in part by the surface receptors for IgG and complement. The link between the binding of complex particulate stimuli to the cell surface, and the triggering of these neutrophil functions, is not completely understood. We have previously described an anti-human neutrophil, murine monoclonal antibody PMN7C3, which specifically inhibits the respiratory burst of neutrophils stimulated with serum-opsonized

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8

Diniz, S. N., R. Nomizo, P. S. Cisalpino, et al. "PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages." Journal of Leukocyte Biology 75, no. 4 (2004): 649–56. http://dx.doi.org/10.1189/jlb.0803371.

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9

Worku, Mulumebet, Max J. Paape, Andrea Di Carlo, Marcus E. Kehrli, and Warren W. Marquardt. "Complement component C3b and immunoglobulin Fc receptors on neutrophils from calves with leukocyte adhesion deficiency." American Journal of Veterinary Research 56, no. 4 (1995): 435–39. http://dx.doi.org/10.2460/ajvr.1995.56.04.435.

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SUMMARY Receptors for opsonins, such as complement component C3b (CR1) and immunoglobulins, Fc receptors, interact with adhesion glycoproteins in mediating immune functions. Defects in expression of the adhesion glycoproteins CD11/CD18 results in severely hampered in vitro and in vivo adherence- related functions of leukocytes. Little is known regarding the effect of leukocyte adhesion deficiency (lad) on ligand binding and receptor expression. We investigated the binding and expression of CR1 and Fc receptors by bovine neutrophils isolated from dairy calves suffering from lad, compared with c

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10

Bartoskova, A., P. Ondrackova, L. Leva, et al. "The effects of in vitro exposure to progesterone and estradiol-17β on the activity of canine neutrophils." Veterinární Medicína 59, No. 4 (2014): 202–9. http://dx.doi.org/10.17221/7481-vetmed.

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To date, only limited information about the influence of ovarian hormones on canine immune system cells has been available. The study investigated the in vitro influence of progesterone and estradiol-17&beta; on the activity of canine neutrophils. Treatment of cells by both hormones led to a significant decrease in phagocytosis-induced oxidative burst as detected using luminometry after stimulation with opsonised zymosan. The increase in oxidative burst, not connected with phagocytosis, was recorded after stimulation with a soluble stimulator. Using flow cytometry, the tendency of both hor

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11

BASSØE, CARL-FREDRIK, and ROBERT BJERKNES. "THE EFFECT OF SERUM OPSONINS ON THE PHAGOCYTOSIS OF STAPHYLOCOCCUS AUREUS AND ZYMOSAN PARTICLES, MEASURED BY FLOW CYTOMETRY." Acta Pathologica Microbiologica Scandinavica Series C: Immunology 92C, no. 1-6 (2009): 51–58. http://dx.doi.org/10.1111/j.1699-0463.1984.tb00051.x.

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12

Watson, G. L., R. F. Slocombe, N. E. Robinson, and S. D. Sleight. "Definition of chemiluminescence and superoxide production responses of bovine neutrophils to selected soluble and particulate stimulants, and comparisons with the responses to Pasteurella haemolytica." American Journal of Veterinary Research 56, no. 8 (1995): 1045–54. http://dx.doi.org/10.2460/ajvr.1995.56.08.1045.

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SUMMARY We defined methods for use of luminol-dependent chemiluminescence (ldcl) and superoxide anion (O2-) production as parameters of the oxidative metabolism of neutrophils isolated from 1.5- to 5-week-old neonatal calves. We determined how variations in blood sample handling, agonist preparation, individual variability, and age of calves influenced the ldcl and O2- responses to certain agonists, and defined concentrations of soluble and particulate agonists that maximally stimulated the oxidative metabolism of bovine neutrophils. Oxidative responses, particularly ldcl, were characterized b

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13

Peterson, Erica A., Jonathan H. Foley, Michael J. Krisinger, and Edward Conway. "Plasmin Cleaves Complement iC3b, Preventing CR3/4 Mediated Phagocytosis By Macrophages." Blood 122, no. 21 (2013): 1105. http://dx.doi.org/10.1182/blood.v122.21.1105.1105.

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Abstract Introduction The plasmin(ogen) and complement systems are activated at sites of tissue injury and are involved in hemostasis, wound healing, inflammation and immune surveillance. Although the mechanisms are poorly understood, dysregulation of these systems underlie the pathogenesis and progression of inflammatory and vascular diseases. We aimed to characterize the relevant molecular interactions between the plasmin(ogen) and complement pathways. The three complement pathways converge with formation of C3-convertases that cleave C3 into C3a and C3b. C3a is liberated as an anaphylatoxin

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14

Dent, Gordon, Mark A. Giembycz, Klaus F. Rabe, and Peter J. Barnes. "Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by ‘type IV’-selective PDE inhibitors." British Journal of Pharmacology 103, no. 2 (1991): 1339–46. http://dx.doi.org/10.1111/j.1476-5381.1991.tb09790.x.

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15

Schnur, R. A., and S. L. Newman. "The respiratory burst response to Histoplasma capsulatum by human neutrophils. Evidence for intracellular trapping of superoxide anion." Journal of Immunology 144, no. 12 (1990): 4765–72. http://dx.doi.org/10.4049/jimmunol.144.12.4765.

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Abstract Human neutrophils (PMN) have received little attention as to the role they play in host defense against Histoplasma capsulatum (Hc). We have characterized the binding and phagocytosis of Hc yeasts by human PMN and quantified the PMN respiratory burst in response to this organism. mAb specific for CD11a, CD11b, and CD11c all partially blocked the attachment of unopsonized yeasts to PMN; a mAb to CD18 inhibited attachment by greater than 90%. Thus, human PMN recognize and bind Hc yeasts via CD18 adhesion receptors as has been found for human cultured macrophages and alveolar macrophages

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16

Czop, J. K., M. F. Gurish, and J. L. Kadish. "Production and isolation of rabbit anti-idiotypic antibodies directed against the human monocyte receptor for yeast beta-glucans." Journal of Immunology 145, no. 3 (1990): 995–1001. http://dx.doi.org/10.4049/jimmunol.145.3.995.

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Abstract beta-Glucan receptors are present on mammalian phagocytic cells and provide an important physiologic mechanism for opsonin-independent clearance of yeasts and fungi. To prepare an immunologic probe to human monocyte beta-glucan receptors, an approach was taken that focused on the ligand specificity of the receptors as expressed by an anti-Id. The algal beta-glucan laminarin was chemically coupled to protein carriers to prepare an immunogenic beta-glucan. Three mouse IgG2a mAb were raised against laminarin, and one, mAb OEA10, exhibited specificity for the soluble unit ligand yeast hep

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17

Fuentes, Ana-Lucía, Leonard Millis, Jacqueline Vapenik, and Lynette Sigola. "Lipopolysaccharide-mediated enhancement of zymosan phagocytosis by RAW 264.7 macrophages is independent of opsonins, laminarin, mannan, and complement receptor 3." Journal of Surgical Research 189, no. 2 (2014): 304–12. http://dx.doi.org/10.1016/j.jss.2014.03.024.

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18

Jiang, W. G., M. C. A. Puntis та M. B. Hallett. "U937 cells stimulated with opsonised zymozan particles provide a convenient laboratory source of tumour necrosis factor α". Journal of Immunological Methods 152, № 2 (1992): 201–7. http://dx.doi.org/10.1016/0022-1759(92)90141-f.

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19

Krumrych, Wiesław, and Janusz Danek. "Chemiluminescence of Peripheral Blood Neutrophils in Mares with Endometritis." Bulletin of the Veterinary Institute in Pulawy 56, no. 1 (2012): 51–56. http://dx.doi.org/10.2478/v10213-012-0010-8.

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Abstract The aim of the study was to evaluate the oxygen metabolism of neutrophils in peripheral blood of mares in relation to intensity of endometrium inflammations. The study involved 36 half-breed mares, aged 4-22 years, showing fertility disturbances. In 26 mares neutrophils were found in uteral smears, which indicated endometritis (15 - moderate inflammation and 11 - severe inflammation). In the rest mares, cytological examination excluded inflammation. Blood samples were evaluated in terms of neutrophils chemiluminescence without stimulation (CL-WS) and with stimulation by opsonised zymo

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20

Karlsson, Sofia, Eewa Nånberg, Christina Fjaeraa, and Jonny Wijkander. "Ellagic acid inhibits lipopolysaccharide-induced expression of enzymes involved in the synthesis of prostaglandin E2 in human monocytes." British Journal of Nutrition 103, no. 8 (2009): 1102–9. http://dx.doi.org/10.1017/s0007114509992935.

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Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has in recent years been the subject of intense research within the fields of cancer and inflammation. Pain, fever and swelling, all typical symptoms of inflammation, are ascribed to elevated levels of PGE2. In the present study, we have investigated the effects of ellagic acid on PGE2 release and on prostaglandin-synthesising enzymes in human monocytes. Ellagic acid was found to inhibit Ca ionophore A23187-, phorbol myristate acetate- and opsonised zymosan-induced release of PGE2 from monocytes pre-treated with t

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21

SUPER, M., R. J. LEVINSKY, and M. W. TURNER. "The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations." Clinical & Experimental Immunology 79, no. 2 (1990): 144–50. http://dx.doi.org/10.1111/j.1365-2249.1990.tb05170.x.

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22

Stokes, Richard W., Lisa M. Thorson, and David P. Speert. "Nonopsonic and Opsonic Association of Mycobacterium tuberculosis with Resident Alveolar Macrophages Is Inefficient." Journal of Immunology 160, no. 11 (1998): 5514–21. http://dx.doi.org/10.4049/jimmunol.160.11.5514.

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Abstract The association of Mycobacterium tuberculosis with alveolar macrophages (Mφ) in a serum-free environment is a crucial first step in the pathogenesis of this facultative intracellular pathogen. We present data demonstrating that freshly explanted alveolar Mφ do not efficiently bind M. tuberculosis in a serum-free system, although a small subpopulation of these Mφ (10–15%) can bind mycobacteria. In contrast, almost 100% of a peritoneal Mφ population bind mycobacteria under the same conditions. The poor binding of mycobacteria by alveolar Mφ does not reflect a general inability to associ

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23

Das, Hemen, Golla Ramalinga Reddy, Tukaram More, and Vineet Kumar Singh. "In Vitro Effects of Certain Membrane-acting Agents on Superoxide and Hydrogen Peroxide Production, Protein Synthesis and Membrane ATPase Activity in Buffalo PMN Cells." Alternatives to Laboratory Animals 35, no. 4 (2007): 397–404. http://dx.doi.org/10.1177/026119290703500404.

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Polymorphonuclear (PMN) cells play a key role in innate immunity, due to their ability to produce reactive oxidants such as superoxide (O2–) and hydrogen peroxide (H2O2), and to release antimicrobial proteins and peptides stored in their lysosomal granules. In the present study, the effects of the activation of buffalo PMN cells with various membrane-acting agents were evaluated in terms of O2– and H2O2 production, the activities of membrane ATPases, and protein synthesis. Studies involving the incorporation of 35S-methionine revealed significant protein-synthesising ability in resting PMN cel

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Coxon, Patricia Y., James T. Summersgill, Julio A. Ramirez, and Richard D. Miller. "Signal Transduction during Legionella pneumophila Entry into Human Monocytes." Infection and Immunity 66, no. 6 (1998): 2905–13. http://dx.doi.org/10.1128/iai.66.6.2905-2913.1998.

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ABSTRACT Legionella pneumophila causes Legionnaires’ disease by replication in alveolar macrophages and monocytes. The bacteria are internalized most efficiently by opsonin-dependent, CR3-mediated phagocytosis. This investigation focused on determining the role of actin polymerization and phosphorylation signals in this uptake mechanism. Uptake inhibition assays and confocal microscopic analysis indicated that entry of L. pneumophila activated tyrosine kinase (TK) and protein kinase C (PKC) and induced actin polymerization at the site of bacterial entry. Upon L. pneumophila entry, six major ce

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25

Koenderman, L., A. T. Tool, D. Roos, and A. J. Verhoeven. "Priming of the respiratory burst in human eosinophils is accompanied by changes in signal transduction." Journal of Immunology 145, no. 11 (1990): 3883–88. http://dx.doi.org/10.4049/jimmunol.145.11.3883.

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Abstract Addition of platelet-activating factor (PAF) to human eosinophils leads to the modulation of eosinophil responses. The respiratory burst, induced by opsonized particles, consists of an initiation and a propagation phase and is greatly enhanced ("primed") after pretreatment with PAF. This priming event induces the following changes in signal transduction between the opsonin receptors (in particular the CR3 receptor) and activation of the respiratory burst: 1) an enhanced activation of protein kinase C (PK-C): the initiation of the respiratory burst in untreated eosinophils is not sensi

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Markiewicz, H., W. Krumrych, and M. Gehrke. "The effect of supportive E. coli mastitis treatment on PMN chemiluminescence and subpopulations of T lymphocytes." Polish Journal of Veterinary Sciences 16, no. 4 (2013): 671–77. http://dx.doi.org/10.2478/pjvs-2013-0095.

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Abstract The aim of this field study was to assess the impact of a single i.m. injection of lysozyme dimer and flunixin meglumine in combination with intramammary and systemic antibiotic on chemiluminescence of PMN (polymorphonuclear leucocytes) and subpopulations of lymphocyte T in blood of cows with E. coli mastitis. Examinations were performed on 30 dairy cows affected with naturally occurring acute form of E. coli mastitis. Cows were randomly divided into three groups according to the method of treatment. The first group was treated with approved intramammary antibiotic product, the same a

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27

Kruskal, B. A., K. Sastry, A. B. Warner, C. E. Mathieu, and R. A. Ezekowitz. "Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor." Journal of Experimental Medicine 176, no. 6 (1992): 1673–80. http://dx.doi.org/10.1084/jem.176.6.1673.

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Phagocytosis has traditionally been viewed as a specialized function of myeloid and monocytic cells. The mannose receptor (MR) is an opsonin-independent phagocytic receptor expressed on tissue macrophages. When human MR cDNA is transfected into Cos cells, these usually non-phagocytic cells express cell surface MR and bind and ingest MR ligands such as zymosan, yeast, and Pneumocystis carinii. Expression of cDNA for Fc gamma RI (CD64), the high-affinity Fc receptor, in Cos cells confers binding but barely detectable phagocytosis of antibody-opsonized erythrocytes (EA). We report here that chime

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Sun, Haimin, Xinlei Chen, Jiang Zhu, Zhu Chen, and Saijuan Chen. "Palladin Regulates Receptor Clustering and Actin Dynamics in Phagocytosis." Blood 128, no. 22 (2016): 2505. http://dx.doi.org/10.1182/blood.v128.22.2505.2505.

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Abstract BACKGROUND: Palladin is an actin microfilament associated protein, which together with myotilin and myopalladin form a novel cytoskeletal IgC2 domain protein family. However, little is known about the function of Palladin in myeloid cells. Here, we focus on the function of Palladin in phagocytosis. METHODS: We used ATRA induced differentiated NB4 cells as neutrophil-like cells, and lenti-viruses were used to build cell lines with palladin or ocrl knockdown and VAMP3-mcherry overexpression. Flow cytometry and immunofluorescence were used to detect the phagocytic ability under condition

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Ellison, Michael A., Daniel R. Ambruso, and Gail Thurman. "Peroxiredoxin 6 Enhances Phagocyte NADPH Oxidase (phox) Activity in Response to Agonists Acting Via Cell Surface Receptors and Intracellular Signaling Pathways." Blood 120, no. 21 (2012): 2139. http://dx.doi.org/10.1182/blood.v120.21.2139.2139.

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Abstract Abstract 2139 Introduction The phagocyte NADPH oxidase (phox) is a multiprotein, transmembrane-enzyme-complex found in diverse professional phagocytes including neutrophils. Phox in its inactive state consists of the membrane-associated subunit cytochrome b558 (a dimer of gp91phox/Nox2 and p22phox) and cytoplasmic subunits which include p47phox, p67phox, p40phox and Rac1 or Rac2. Phosphorylation of phox proteins promotes tight interaction of the cytoplasmic phox components with cytochrome b558 and the resulting active complex catalyzes transmembrane electron transfer from cytoplasmic

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Liu, Jie, Coralie Pintard, Nathalie Thieblemont, Pham My-Chan Dang, and Jamel El Benna. "Deciphering opsonized zymosan-induced phosphorylation of p47phox and NADPH oxidase activation in human neutrophils." Blood Journal, June 25, 2025. https://doi.org/10.1182/blood.2024027018.

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Neutrophils play a key role in innate immunity by killing microbes through phagocytosis and superoxide anion production by the phagocyte NADPH oxidase. The signaling pathways regulating NADPH oxidase activation in neutrophils have been extensively studied using soluble agonists, but are less understood during phagocytosis, a fundamental function of neutrophils. The aim of this study was to investigate the phosphorylation of the cytosolic NADPH oxidase protein p47phox in human neutrophils stimulated by serum-opsonized zymosan (OZ), which induces phagocytosis, using antibodies against phosphoryl

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