Einloggen

Thematische Bibliographien / Lungs Inflammation / Dissertationen

Um die anderen Arten von Veröffentlichungen zu diesem Thema anzuzeigen, folgen Sie diesem Link: Lungs Inflammation.

Dissertationen zum Thema „Lungs Inflammation“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 27. Januar 2023

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an

Wählen Sie eine Art der Quelle aus:

Machen Sie sich mit Top-50 Dissertationen für die Forschung zum Thema "Lungs Inflammation" bekannt.

Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.

Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.

Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.

1

McLennan, Geoffrey. "Oxygen toxicity and radiation injury to the pulmonary system." Title page, index and forward only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm164.pdf.

Der volle Inhalt der Quelle

Annotation:

Bibliography: leaves 168-184. The work in this study encompasses oxygen free radical related inflammation in the peripheral lung and in lung cells. Animal and human studies have been used. Methods include cell culture with function studies, protein chemistry, animal and human physiology, and cell and lung structure through histopathology, and various forms of electron microscopy. The work resulting from this thesis has formed an important basis for understanding acute and chronic lung injury.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

2

Corsino, Betsy Ann 1962. "THE PULMONARY RESPONSE INDUCED BY GLASS FIBERS (INFLAMMATION, SILICOSIS, MURINE MODEL)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291468.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

3

Dokka, Sujatha. "IL-10 gene therapy for the treatment of pulmonary inflammation." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1421.

Der volle Inhalt der Quelle

Annotation:

Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 132 p. : ill. (some col.) Vita. Includes abstract. Includes bibliographical references.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

4

Finlay, Alison. "Kinetics of pulmonary eosinophilia in a mouse model." Thesis, University of York, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245971.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

5

Karandashova, Sophia. "The Role of Ceramide in Neutrophil Elastase Induced Inflammation in the Lungs." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5468.

Der volle Inhalt der Quelle

Annotation:

Alterations to sphingolipid metabolism are associated with increased pulmonary inflammation, but the impact of inflammatory mediators, such as neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. NE is a protease associated CF lung disease progression, and can be found in up to micromolar concentrations in patient airways. While sphingolipids have been investigated in the context of CF, the focus has been on loss of cystic fibrosis transmembrane conductance regulator (CFTR) function. Here, we present a novel observation: oropharyngeal aspiration of NE increases airway

APA, Harvard, Vancouver, ISO und andere Zitierweisen

6

McDaniel, Dylan K. "Characterization of Biomedical and Incidental Nanoparticles in the Lungs and Their Effects on Health." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/86128.

Der volle Inhalt der Quelle

Annotation:

Nanomaterials are defined as any material with at least one external dimension less than 100 nm. Recently, nanomaterials have become more common in medicine, technology, and engineering. One reason for their increased interest is due to nanomaterials having unique properties that allow them to interact effectively with biological systems. In terms of drug delivery, the lungs are a highly desirable site to administer therapeutic nanoparticles. Indeed, inflammatory diseases such as asthma and emphysema could potentially benefit from nanoparticle-mediated delivery. However, the lungs are also in

APA, Harvard, Vancouver, ISO und andere Zitierweisen

7

Zheng, Ling 1958. "Airway inflammation and remodelling post human lung transplantation." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8099.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

8

Lewis, Joshua B. "Alterations in Tight Junctional Proteins and Their Effects on Pulmonary Inflammation." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6308.

Der volle Inhalt der Quelle

Annotation:

The lungs represent one of the earliest interfaces for pathogens and noxious stimuli to interact with the body. As such, careful maintenance of the permeability barrier is vital in providing homeostasis within the lung. Essential to maintaining this barrier is the tight junction, which primarily acts as a paracellular seal and regulator of ionic transport, but also contributes to establishing cell polarity, cell-to-cell integrity, and regulating cell proliferation and differentiation. The loss of these tight junctions has been documented to result in alterations in inflammation, and ultimat

APA, Harvard, Vancouver, ISO und andere Zitierweisen

9

Lau, Kwok-wai, and 劉國威. "The involvement of serotoninergic system in cigarette smoke-induced oxidative stress and inflammation: relevantto chronic obstructive pulmonary disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869616.

Der volle Inhalt der Quelle

Annotation:

Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD) with chronic airway inflammation as a key feature. Currently, no effective treatment can reduce the protracted inflammation in the lung of COPD. Further research on the inflammatory mechanisms would therefore be important in determining new potential therapeutic targets in COPD. Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays an important role in pulmonary functions and inflammatory responses. The serotoninergic system including serotonin trans

APA, Harvard, Vancouver, ISO und andere Zitierweisen

10

McNamara, Tracy Renee. "Chlamydia pneumoniae and airways inflammation : an investigation of the host cell-pathogen relationship /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phm4791.pdf.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

11

Minucci, Sarah B. "Mathematical Models of the Inflammatory Response in the Lungs." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5191.

Der volle Inhalt der Quelle

Annotation:

Inflammation in the lungs can occur for many reasons, from bacterial infections to stretch by mechanical ventilation. In this work we compare and contrast various mathematical models for lung injuries in the categories of acute infection, latent versus active infection, and particulate inhalation. We focus on systems of ordinary differential equations (ODEs), agent-based models (ABMs), and Boolean networks. Each type of model provides different insight into the immune response to damage in the lungs. This knowledge includes a better understanding of the complex dynamics of immune cells, protei

APA, Harvard, Vancouver, ISO und andere Zitierweisen

12

Henry, Clémence. "Caractérisation du rôle du canal calcique TRPV4 dans la réponse inflammatoire pulmonaire : implication dans la mucoviscidose." Thesis, Tours, 2014. http://www.theses.fr/2014TOUR4037.

Der volle Inhalt der Quelle

Annotation:

La mucoviscidose est une maladie génétique dont l’atteinte respiratoire est responsable de 90 % de la morbidité et de la mortalité et est caractérisée par une infection chronique et une inflammation persistante. Cette inflammation non contrôlée participe de manière importante à la dégradation du tissu pulmonaire. Malgré les progrès récents, les thérapies actuelles ne permettent pas un traitement efficace de l’atteinte respiratoire. Il est donc indispensable d’identifier de nouveaux mécanismes moléculaires et cellulaires impliqués dans l’inflammation pulmonaire. Dans ce but, nous nous sommes in

APA, Harvard, Vancouver, ISO und andere Zitierweisen

13

Carroll, Mark. "A stereological study assessing the validity of using endobronchial biopsies to assess mast cell density in the central and peripheral bronchial tree." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0005.

Der volle Inhalt der Quelle

Annotation:

[Tuncated abstract] There has been longstanding concern over whether endobronchial biopsies adequately represent inflammation throughout the bronchial tree in diseases such as asthma, despite the endobronchial biopsy technique having been used frequently to assess airway inflammation in research settings. There has also been ongoing debate about whether endobronchial biopsies should be assessed by new, unbiased, three-dimensional (3D) stereological techniques instead of traditional, two-dimensional (2D) non-stereological techniques. Therefore, the aims of this study were: (i) to investigate wh

APA, Harvard, Vancouver, ISO und andere Zitierweisen

14

Ruiz, Karina Fernandes. "Efeito do DMTI-II, um inibidor de Kunitz isolado das sementes de Dimorphandra molli na resposta inflamatória pulmonar alérgica em ratos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308917.

Der volle Inhalt der Quelle

Annotation:

Orientador: Edson Antunes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Medicas<br>Made available in DSpace on 2018-08-16T20:02:44Z (GMT). No. of bitstreams: 1 Ruiz_KarinaFernandes_M.pdf: 791032 bytes, checksum: 0730a107f795b476b046410752e6a5e3 (MD5) Previous issue date: 2010<br>Resumo: DMTI-II é um inibidor de serinoproteinase do tipo Kunitz, isolado a partir das sementes de Dimorphandra mollis, uma árvore da família Leguminosae-Mimosoidea, com ampla distribuição nas regiões do cerrado brasileiro e popularmente conhecida por causar toxicidade em gados

APA, Harvard, Vancouver, ISO und andere Zitierweisen

15

Vanderstocken, Gilles. "Caractérisation du rôle des nucléotides extracellulaires et du récepteur purinergique P2Y2 dans la physiopathologie des maladies pulmonaires inflammatoires." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209591.

Der volle Inhalt der Quelle

Annotation:

Amongst respiratory diseases, inflammatory lung diseases constitute a major part of public <p>health problem. As a consequence, investigating the immune mechanisms that contribute to <p>the pathogenesis of these diseases is essential to identify candidate targets for the <p>development of new therapeutic drugs. Furthermore, over the past 20 years, the growing awareness <p>that purinergic signalling events shape the immune and inflammatory responses to infection and <p>allergic reactions warranted the development of animal models to assess their importance in vivo in <p>acute lung injury and ch

APA, Harvard, Vancouver, ISO und andere Zitierweisen

16

Cooper, Racheal L. "An Applied Mathematics Approach to Modeling Inflammation: Hematopoietic Bone Marrow Stem Cells, Systemic Estrogen and Wound Healing and Gas Exchange in the Lungs and Body." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4312.

Der volle Inhalt der Quelle

Annotation:

Mathematical models apply to a multitude physiological processes and are used to make predictions and analyze outcomes of these processes. Specifically, in the medical field, a mathematical model uses a set of initial conditions that represents a physiological state as input and a set of parameter values are used to describe the interaction between variables being modeled. These models are used to analyze possible outcomes, and assist physicians in choosing the most appropriate treatment options for a particular situation. We aim to use mathematical modeling to analyze the dynamics of processe

APA, Harvard, Vancouver, ISO und andere Zitierweisen

17

Marwick, John Alexander. "The impact of cigarette smoke on cell survival and inflammation in rat lungs : the role of oxidative stress and VEGF/KDR signalling and its implications in COPD." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/24912.

Der volle Inhalt der Quelle

Annotation:

A decrease in both VEGF and KDR was observed in rat lungs exposed to cigarette smoke as well as disruption to the other components of their signalling complex, neurophilin-1 and glycpican-1. Impaired survival signalling in rat lungs exposed to cigarette smoke was also demonstrated. These changes were mirrored in both smokers and COPD lungs, indicating that these changes may play a role in cigarette smoke induced COPD. Cigarette smoke-triggered inflammation in COPD may be maintained by a mechanism involving enhanced pro-inflammatory gene transcription. The balance between histone acetylation an

APA, Harvard, Vancouver, ISO und andere Zitierweisen

18

Fallata, Ghaith Mohammed. "Association of gut luminal metabolites and allergic responses." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1515185113264117.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

19

Saleh, Yara. "Etude de la pathogénicité pulmonaire des polluants atmosphériques nanoparticulaires." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S014.

Der volle Inhalt der Quelle

Annotation:

Introduction : Des études épidémiologiques montrent que les polluants atmosphériques particulaires augmentent le risque de morbidité et de mortalité liées à des maladies respiratoires. La toxicité des particules dépend de leur composition chimique, leur conférant des propriétés mutagènes et/ou cancérogènes, mais également de leur granulométrie qui va conditionner leur pénétration et rétention dans les voies respiratoires.Les particules fines (PF<2,5μm) et surtout les particules ultrafines (PUF<0,1μm) peuvent ainsi atteindre les voies aériennes les plus profondes où leur épuration s’effec

APA, Harvard, Vancouver, ISO und andere Zitierweisen

20

Haegens, Astrid. "Role of Myeloperoxidase in lung inflammation." Maastricht : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=11652.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

21

Nelson, Kevin Joseph. "MICRORNA REGULATION OF VENTILATOR INDUCED LUNG INJURY AND PRESSURE-INDUCED LUNG INFLAMMATION." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462276463.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

22

Shoemark, Amelia. "Non invasive measurement of lung inflammation in bronchiectasis." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509803.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

23

Lai, Cheryl Chuk-Ke. "Therapeutic manipulation of inflammation in exacerbated lung disease." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/61486.

Der volle Inhalt der Quelle

Annotation:

It is well known that existing and prior inflammatory events in the lung can adversely affect subsequent inflammatory events even though the inciting antigen might be different. For example, viral infections can enhance secondary bacterial infections and also the symptoms of asthma causing increased morbidity and mortality. Understanding changes in the lung micro-environment that lead to altered lung responsiveness is important given the increasing incidence in allergic diseases and the emergence of pandemic influenza strains. Elucidating the molecular mechanisms of these prolonged alterations

APA, Harvard, Vancouver, ISO und andere Zitierweisen

24

Farghaly, Hanan. "Pharmacological targets for gene therapy in lung inflammation." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500756.

Der volle Inhalt der Quelle

Annotation:

Interleukin-13 (IL-13) has been implicated as a critical inducer of a number of features of allergy and asthma including the induction of nonspecific airway hyperresponsiveness (AHR), eosinophilic inflammatory response, eotaxin production, excess mucus formation, and fibrosis. Determining the mechanism(s) of AHR, a hallmark of asthma, is crucial to our understanding of both the pathogenesis and successful treatment of asthma. After carrying out initial experiments to determine the effect of IL-13-induced AHR on murine and rat tracheal rings, mice tissues were chosen for subsequent experiments

APA, Harvard, Vancouver, ISO und andere Zitierweisen

25

Rodriguez, Ihsan. "Well-being and Inflammation in Interstitial Lung Disease." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619031719578262.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

26

Larsson, Emelie Olivia. "Immune to brain communication in allergic lung inflammation." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/355709/.

Der volle Inhalt der Quelle

Annotation:

Asthma, a chronic TH2-mediated inflammatory disease of the airways, is the most common form of allergy in the Western world, affecting 300 million people worldwide. Epidemiological studies have shown that asthma is associated with mood disorders, such as anxiety and depression, and numerous experiments have reported that asthma induces functional changes in neuronal fibres of the peripheral nervous system (PNS), which innervate the brain. It is unknown, however, how allergic lung inflammation impacts on the central nervous system (CNS). The ability for peripheral inflammation to impact on the

APA, Harvard, Vancouver, ISO und andere Zitierweisen

27

Blohmke, Christoph Johannes. "Innate immunity and inflammation in cystic fibrosis lung disease." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34559.

Der volle Inhalt der Quelle

Annotation:

Inflammatory lung disease is the major life-limiting factor of cystic fibrosis (CF) and occurs through a self-sustaining cycle of airway obstruction, infection and inflammation. Although there is no consensus regarding the pathways responsible for the excessive inflammation, reducing lung-damaging pro-inflammatory responses are likely to be beneficial for CF patients. Using CF (IB3-1) and non-CF control (C38) respiratory cells, the host-pathogen interaction between the airway epithelium and the common CF pathogens P. aeruginosa and B. cepacia was investigated. Using purified Toll-like receptor

APA, Harvard, Vancouver, ISO und andere Zitierweisen

28

McClean, K. M. "Nutrition, Inflammation and Lung Function in Middle-Aged Men." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

29

Clayton, Andrew Alan. "Linking lung inflammation and chloride secretion in cystic fibrosis." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433982.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

30

Phillips, Gary John. "The role of inflammation in hyperoxia-induced lung injury." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295865.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

31

Sundaram, Kruthika. "Expression And Function Of Human IkappaBzeta In Lung Inflammation." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436224271.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

32

Lyonga, Daphne E. "The regulation of lung homeostasis and influenza-associated inflammation." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7127.

Der volle Inhalt der Quelle

Annotation:

Alveolar macrophages are the main cell population in the naïve airway and are held in a state of tight regulation by several suppressive mechanisms. One would expect them to display a regulatory phenotype but here we show that at homeostasis they express markers of alternative activation such as YM1 and mannose receptor (MR) but not resistin-like molecule (RELM)-α. We show also that these markers are differentially regulated during influenza infection on macrophage populations in the lungs and airways. We hypothesised that removing the suppressive effects of IL-10 using an IL-10R blocking anti

APA, Harvard, Vancouver, ISO und andere Zitierweisen

33

Lucas, Christopher David. "Modulation of inflammatory cell apoptosis in infection-associated inflammation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17874.

Der volle Inhalt der Quelle

Annotation:

Neutrophils are a central component of the innate immune system, whose major role is to defend the host against invading microorganisms. As such they are integral players in the process of inflammation, the response of vascular tissues to injury. They are frequently the first immune cells recruited from the systemic circulation into a site of tissue injury or infection where they themselves play a key antimicrobial role. Direct killing of microbes can be accomplished by phagocytosis, degranulation, production of reactive oxygen species (ROS) or the release of DNA and antimicrobial peptides int

APA, Harvard, Vancouver, ISO und andere Zitierweisen

34

Pariollaud, Marie. "Role of REV-ERBα in the regulation of lung inflammation". Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html.

Der volle Inhalt der Quelle

Annotation:

The clock-controlled nuclear receptor REV-ERBα has emerged as a critical regulator of multiple pathways involved in metabolism, development and immunity. Recent evidence has highlighted a major role for the clock in epithelial cells regulating lung inflammation, mediated by control of neutrophil chemokine expression. In this thesis, I examined the role of REV-ERBα in pulmonary immunity, using in-vivo gene targeting and nebulised lipopolysaccharide (LPS), a model for gram-negative bacterial infection, ex-vivo cell biology approaches and in vitro cell models. Initial studies of Rev-Erbα knock-ou

APA, Harvard, Vancouver, ISO und andere Zitierweisen

35

Jonasson, Sofia. "Lung mechanics and airway inflammation in murine models of asthma." Doctoral thesis, Uppsala universitet, Klinisk fysiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107061.

Der volle Inhalt der Quelle

Annotation:

Allergic asthma is an inflammatory disease of the airways and is characterized by eosinophilic inflammation and increased airway reactivity. In the studies presented in this thesis, lung mechanics and measurements of airway reactivity were assessed in anaesthetized tracheostomized mice by using an animal ventilator (flexiVent®). A forced oscillation technique makes it possible to measure of both airway and tissue mechanics with a potential to distinguish between central and peripheral airways. The results of the experiments on lung mechanics imply that it is important to understand how altered

APA, Harvard, Vancouver, ISO und andere Zitierweisen

36

Dakin, Carolyn Women's &amp Children's Health Faculty of Medicine UNSW. "Infection and inflammation in children with cystic fibrosis lung disease." Awarded by:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/44624.

Der volle Inhalt der Quelle

Annotation:

The purpose of this study was to examine the relationships between inflammation, infection and lung function in cystic fibrosis during the evolution of lung disease in childhood and early adolescence. The developmental stages of childhood and the progression of lung disease together affected the methods and techniques used in the study, with the consequence that the work for this thesis fell naturally into two parts. The first part concerned the study of early lung disease in infants and young children who were unable to expectorate or to cooperate with lung function testing. In the second par

APA, Harvard, Vancouver, ISO und andere Zitierweisen

37

Yang, Fu. "Role and regulation of 11β-hydroxysteroid dehydrogenase in lung inflammation". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4828.

Der volle Inhalt der Quelle

Annotation:

Glucocorticoids are steroid hormones that have potent anti-inflammatory actions. Endogenous glucocorticoid action is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyses the interconversion of active glucocorticoids (cortisol, corticosterone) and intrinsically inert forms (cortisone, 11-dehydrocorticosterone). There are 2 isozymes; 11β-HSD type 1 regenerates active glucocorticoids in vivo whereas 11β-HSD type 2 inactivates glucocorticoids. Although 11β-HSD1 is highly expressed in the lung, its role there has been little explored. In this study, the expression and localizatio

APA, Harvard, Vancouver, ISO und andere Zitierweisen

38

Koch, Andrea. "Clinical Aspects of Inflammation in Non-small Cell Lung Cancer." Doctoral thesis, Linköpings universitet, Internmedicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68749.

Der volle Inhalt der Quelle

Annotation:

Lung cancer is the most common cause of cancer death worldwide, with about 1.2 million deaths every year. In Sweden, about 3500 new cases are diagnosed every year. The majority of patients presents with advanced non-small cell lung cancer (NSCLC) and is treated with palliative intent. Standard treatment in these patients in performance status 0-2 is combination chemotherapy. Radiotherapy may be added for palliative purposes. Median survival time with such treatment is 6-10 months. New treatment strategies are urgently needed. There is growing evidence for a link between cancer and inflammation

APA, Harvard, Vancouver, ISO und andere Zitierweisen

39

Brown, Sarah. "Mechanisms of resolution of inflammation in paediatric neutrophilic lung disease." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/56921.

Der volle Inhalt der Quelle

Annotation:

Many paediatric airway diseases are characterised by persistent neutrophilic inflammation, which can lead to damage to the airways and lung parenchyma. One possible mechanism for the persistence of neutrophilic inflammation is failure of the normal active resolution of the inflammatory process. There is limited published literature on the role of inflammatory resolution in paediatric inflammatory lung disease. It is possible that targeting inflammatory resolution mechanisms and the ability to “switch off” inflammation may provide therapeutic targets in the future for these diseases. This thesi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

40

Barr, Laura Caroline. "Peripheral blood mononuclear cell depletion for experimental human lung inflammation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/23705.

Der volle Inhalt der Quelle

Annotation:

Acute lung injury (ALI) affects a significant proportion of patients requiring critical care and is associated with high morbidity and mortality. Treatment is currently only supportive, with no pharmacological treatment yet shown to definitively improve outcome. There is evidence from murine models of ALI that monocytes play a key role in the development of the neutrophilic lung infiltration characteristic of ALI. Depletion of blood monocytes in mice given intra-tracheal lipopolysaccharide (LPS) significantly reduces pulmonary neutrophil influx, systemic neutrophilia and other markers of lung

APA, Harvard, Vancouver, ISO und andere Zitierweisen

41

MacGregor, Gordon. "Non-invasive markers of inflammation in cystic fibrosis lung disease." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4834.

Der volle Inhalt der Quelle

Annotation:

Cystic fibrosis (CF) lung disease is characterised by early airways infection and inflammation, chronic suppuration, frequent infective exacerbations and an increased influx of acute, and chronic inflammatory cells. The inflammatory process involves activation of many cell types including neutrophils, macrophages and epithelial cells, and leads ultimately to the development of progressive respiratory failure and death. Accurate assessment of the inflammatory process is a crucial part of disease monitoring and should allow appropriate evaluation of therapeutic interventions so as to maximize co

APA, Harvard, Vancouver, ISO und andere Zitierweisen

42

Singh, Ravinder. "The role of Death Receptor 3 in allergic lung inflammation." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/56963/.

Der volle Inhalt der Quelle

Annotation:

Death Receptor 3 (DR3) is a death domain containing member of the TNF Receptor Superfamily (TNFRSF), refereeing a range of cellular responses from differentiation and proliferation to cell death, depending upon the context of receptor activation. DR3 has been reported to have a role in many inflammatory diseases, including inflammatory arthritis and inflammatory bowel disease. The aim of this study was to determine the contribution of DR3 in a mouse model of acute and chronic allergic lung inflammation. Mice genetically deficient in the DR3 gene (DR3ko) were resistant to cellular accumulation

APA, Harvard, Vancouver, ISO und andere Zitierweisen

43

Xin, Gang. "The role of TREM proteins in lung homeostasis and inflammation." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9058.

Der volle Inhalt der Quelle

Annotation:

The family of Triggering Receptors Expressed on Myeloid Cells (TREM) contain novel activating receptors of the Ig super-family that are expressed on myeloid cells. TREM-1 is a transmembrane glycoprotein expressed on blood neutrophils and a subset of monocytes, but not on lymphocytes or other cell types and is upregulated by bacterial and fungal products. TREM-1 signaling potentiates the outcome of Toll-like Receptor (TLR) signaling. Blockade of TREM-1 prevents experimentally induced septic shock. In addition to the membrane-bound form, a soluble TREM-1 molecule (sTREM-1) exists that regulates

APA, Harvard, Vancouver, ISO und andere Zitierweisen

44

White, Anna-Marie. "The role of tumour necrosis factor α in lung inflammation". Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362198.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

45

Morla, Shravan. "Glycosaminoglycan Mimetics for the Treatment of Cancer and Lung Inflammation." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5948.

Der volle Inhalt der Quelle

Annotation:

Glycosaminoglycans (GAGs) are linear polysaccharides whose disaccharide building blocks consist of an amino sugar and either uronic acid or galactose. They are expressed on virtually all mammalian cells, usually covalently attached to proteins, forming proteoglycans. GAGs are highly negatively charged due to an abundance of sulfate and carboxylic acid groups, and are structurally very diverse, with differences arising from chain length, the type of monomeric units, the linkages between each monomeric unit, the position of sulfate groups, and the degree of sulfation. GAGs are known to interact

APA, Harvard, Vancouver, ISO und andere Zitierweisen

46

McNeil, Kathryn Suzanne. "Nitrosative and oxidative stress in Nippostrongylus brasiliensis induced pulmonary inflammation." Thesis, Edinburgh Napier University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312974.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

47

Hedbrant, Alexander. "Cancer and Inflammation : Role of Macrophages and Monocytes." Doctoral thesis, Karlstads universitet, Institutionen för hälsovetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-37086.

Der volle Inhalt der Quelle

Annotation:

Macrophages are cells of the innate immune system that can be found in large quantities in cancer tumors and affect cancer progression by regulating growth and invasiveness of cancer cells. There are two main phenotypes of macrophages denoted M1 and M2. In this thesis, the M1 and M2 phenotype of human macrophages were characterized, and effects of the macrophages on the growth and invasiveness of colon and lung cancer cells were studied. Macrophages of the M1 phenotype, but not the M2 phenotype, inhibited growth of both colon and lung cancer cells, and the inhibition for some of the cancer cel

APA, Harvard, Vancouver, ISO und andere Zitierweisen

48

Sánchez, Vidaurre Sara. "Non-invasive methods to study lung inflammation in work-related asthma." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96716.

Der volle Inhalt der Quelle

Annotation:

El asma relacionado con el trabajo (ART) incluye el asma ocupacional (AO) y el asma exacerbado por el trabajo (AET), y representa un problema de salud importante con un negativo impacto socio-económico. El AO se refiere al asma causado de novo por exposición a un agente específico en el lugar de trabajo, y el AET se define como un empeoramiento de un asma preexistente o concomitante agravado por las condiciones de trabajo. Al igual que el asma bronquial, el ART es una enfermedad inflamatoria crónica heterogénea de las vías respiratorias. La inflamación bronquial es un reflejo directo de la e

APA, Harvard, Vancouver, ISO und andere Zitierweisen

49

Thakur, Sheetal A. "Role of scavenger receptor MARCO in particle uptake and lung inflammation." The University of Montana, 2009. http://etd.lib.umt.edu/theses/available/etd-10302008-102542/.

Der volle Inhalt der Quelle

Annotation:

Alveolar macrophages (AM) form the first line of defense against chronic inflammation caused by occupational exposure to environmental particulates such as crystalline silica (CSiO2). The chronic inflammatory process triggered by CSiO2 is known to culminate into a fibrotic response called silicosis in the human lungs. Previous studies have indicated the role of membrane glycoproteins called scavenger receptors in binding of environmental particles. The scavenger receptors are classified into different classes (A-H) based on their structure and function. Class A scavenger receptors are critical

APA, Harvard, Vancouver, ISO und andere Zitierweisen

50

Cornejo, Perales Salomon. "Mechanisms of glucocorticoid responsiveness in the lung during development and inflammation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116918.

Der volle Inhalt der Quelle

Annotation:

Glucocorticoids (GCs) are vital hormones involved in lung development and the regulation of the inflammatory/immune response. High inter-individual variability in GC responsiveness exists among patients using steroids as treatment for inflammatory diseases. Evidence suggests that vitamin D (VitD), another player in lung development, improves GC function. Even though progress has been made in the study of steroid insensitivity, the molecular mechanisms are not completely elucidated and the effects of limited GC response during lung development have not been explored. The first objective of the

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Wir bieten Rabatte auf alle Premium-Pläne für Autoren, deren Werke in thematische Literatursammlungen aufgenommen wurden. Kontaktieren Sie uns, um einen einzigartigen Promo-Code zu erhalten!