Добірка наукової літератури з теми "Chimical Diversity"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Chimical Diversity".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Chimical Diversity"
Awale, Mahendra, Ricardo Visini, Daniel Probst, Josep Arús-Pous, and Jean-Louis Reymond. "Chemical Space: Big Data Challenge for Molecular Diversity." CHIMIA International Journal for Chemistry 71, no. 10 (October 25, 2017): 661–66. http://dx.doi.org/10.2533/chimia.2017.661.
Повний текст джерелаSchröder, Jens A., and Pauline E. Jullien. "The Diversity of Plant Small RNAs Silencing Mechanisms." CHIMIA International Journal for Chemistry 73, no. 5 (May 29, 2019): 362–67. http://dx.doi.org/10.2533/chimia.2019.362.
Повний текст джерелаFabrizio, Alberto, Ksenia Briling, Andrea Grisafi, and Clémence Corminboeuf. "Learning (from) the Electron Density: Transferability, Conformational and Chemical Diversity." CHIMIA International Journal for Chemistry 74, no. 4 (April 29, 2020): 232–36. http://dx.doi.org/10.2533/chimia.2020.232.
Повний текст джерелаWolfender, Jean-Luc, and Emerson Ferreira Queiroz. "Chemical Diversity of Natural Resources and the Bioactivity of their Constituents." CHIMIA International Journal for Chemistry 66, no. 5 (May 30, 2012): 324–29. http://dx.doi.org/10.2533/chimia.2012.324.
Повний текст джерелаIla, Hiriyakkanavar, and Hiriyakkanavar Junjappa. "Molecular Diversity through Novel Organosulfur Synthons: Versatile Templates for Heterocycle Synthesis." CHIMIA International Journal for Chemistry 67, no. 1 (February 27, 2013): 17–22. http://dx.doi.org/10.2533/chimia.2013.17.
Повний текст джерелаKang, Chengjun, and Andrei Honciuc. "A Diversity of Asymmetric Nano-/Microcolloidal Architectures Grown by ATRP from Janus Seeds." CHIMIA International Journal for Chemistry 73, no. 4 (April 24, 2019): 324–28. http://dx.doi.org/10.2533/chimia.2019.324.
Повний текст джерелаMuñiz, Manuel, and Auxiliadora Aguilera-Romero. "A Role for Lipids in Protein Sorting?" CHIMIA 75, no. 12 (December 9, 2021): 1026. http://dx.doi.org/10.2533/chimia.2021.1026.
Повний текст джерелаProbst, Daniel. "The Societal and Scientific Importance of Inclusivity, Diversity, and Equity in Machine Learning for Chemistry." CHIMIA 77, no. 1/2 (February 22, 2023): 56. http://dx.doi.org/10.2533/chimia.2023.56.
Повний текст джерелаWennemers, Helma. "Peptides – Molecular Allrounders." CHIMIA International Journal for Chemistry 75, no. 6 (June 30, 2021): 525–29. http://dx.doi.org/10.2533/chimia.2021.525.
Повний текст джерелаSimon, Clémence, Suihan Feng, and Howard Riezman. "Chemical Biology Tools to Study Lipids and their Metabolism with Increased Spatial and Temporal Resolution." CHIMIA 75, no. 12 (December 9, 2021): 1012. http://dx.doi.org/10.2533/chimia.2021.1012.
Повний текст джерелаДисертації з теми "Chimical Diversity"
Sewsurn, Steffi. "Bio-ingénierie de la voie métabolique des pyrrocidines pour la génération d’une diversité chimique dans cette famille de composés." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS506.pdf.
Повний текст джерелаThe filamentous fungus Sarocladium zeae, an endophyte of maize, produces complex polycyclic metabolites known as pyrrocidines. These compounds have attractive biological activities, such as antimicrobial, apoptotic and mycotoxin biosynthesis regulation in certain plant pathogens. These molecules belong to a growing family of fungal compounds sharing a decahydrofluorene core connected to a highly strain paracyclophane with ten stereogenic centers. A study carried out by the team, combining gene inactivation in the biosynthetic cluster and metabolic analysis, led to the characterization of a wide diversity of metabolites and established a biosynthetic pathway for pyrrocidines. The formation of the carbon backbone of these compounds is governed by a hybrid mega-enzyme, a polyketide synthase - non-ribosomal peptide synthetase (PKS-NRPS) composed of ten domains. The polycyclic system is then built up by auxiliary enzymes. A study of these key enzymes carried out as part of this thesis proposed a molecular mechanism for the formation and stereochemical control of the paracyclophane-decahydrofluorene motif. In order to generate chemodiversity in the pyrrocidine family to access molecules with potential biological activities, two complementary bioengineering approaches were considered. One involves replacing key auxiliary enzymes in the formation of paracyclophane-decahydrofluoren core with others from various similar gene clusters. The other approach involves reprogramming the catalytic sequence of PKS-NRPS to generate diverse carbon skeletons by reassembling the catalytic domains of various megasynthases identified in fungal genomes. A first proof-of-concept was provided by deconstructing the native PKS-NRPS gene according to these domains in silico, then reassembling it in vitro by modular cloning
ROSAR, VERA. "The importance of ligand structural diversity in palladium catalyzed polymerization." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908017.
Повний текст джерелаThe main goal of the PhD research was the development of novel homogeneous catalysts for copolymerization of ethylene with polar vinyl monomers, such as acrylic esters, in order to obtain functionalized polyolefins with a controlled content of the inserted polar monomer. The project focused on the synthesis and characterization of palladium(II) complexes with novel non symmetric nitrogen-donor ligands of increasing complexity, and belonging either to the class of alpha-diimines or to the group of the pyridylimines. The catalytic behaviour of the synthesized palladium(II) complexes in the ethylene/methyl acrylate copolymerization was investigated in detail. Some of the catalysts were also applied to other reactions such as the CO/vinyl arene copolymerization and the bis-alkoxycarbonylation of alkenes, demonstrating the versatility of palladium catalysts with N-donor ligands.
BONANDI, ELISA. "EXPLORATION OF THE CHEMICAL SPACE: DIVERSITY-ORIENTED AND CHEMOENZYMATIC APPROACHES." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/704101.
Повний текст джерелаThis dissertation is an overview of a three-years project, aimed at the exploration of new regions of the chemical space, that could contain new unusual bioactive compounds. The already discovered small molecules cover only a small portion of the chemical universe, that becomes even narrower when bioactive compounds are considered. In this context, two different strategies for the investigation of the chemical space have been considered: the diversity oriented-synthesis (DOS), that constitute the major topic of the work, and a chemoenzymatic approach, developed during a period spent at the University of Warwick (UK), in the laboratory of Professor M. Tosin. Chapter 1 deals with the general principles of the DOS approach, focusing then the attention on a library of piperidine-based compounds previously synthesised in Professor Passarella’s research group, starting from a common precursor, 2-piperidine ethanol (1). An overview of the main results previously accessed in this field is reported. At the end of the chapter, the planning of a further expansion of this library is presented. The structure of the newly accessed piperidine-based products is appreciable in Figure 1 (see Figure 1 in the abstarct version reported in the thesis file); their obtainment was the main goal of this thesis. Chapter 2 is focused on the stereoselective synthesis of eight highly diversified polyheterocyclic compounds, characterized by three different scaffolds. In particular, the different scaffolds were originated by the same precursor, considering that its different syn- or anti- stereocenter configuration, influenced the reaction outcome. This project opens the possibility of accessing analogs of some natural products, such as lupin and lycopodium alkaloids. Chapter 3 concerned the obtainment of a library of potential Hedgehog (Hh) signalling pathway inhibitors, rationally designed exploiting docking simulations and taking inspiration from a class of natural products, the withanolides. The designed scaffold contains two key motif, a bicyclic carbamate and an α,β-unsaturated lactone, and presents three stereocenters. So far, two out of the four racemic isomers have been accessed and biological evaluation revealed two interesting intermediates, that have been synthesised also as separate enantiomers. Moreover, preliminary studies toward the obtainment of 2nd generation inhibitors have been performed in our laboratory. Biological evaluation of these compounds is currently in progress and will orient the future development of this work. Chapter 4 is aimed at the synthesis of (-)-anaferine as an unexpected further ramification of our DOS approach. Key intermediate 10, already exploited for the synthesis of the inhibitors of chapter 3, has been employed as starting material, converting its homoallylic alcohol into an α,β-unsaturated lactam. To this extent, the same approach used in chapter 1, to transform 9 into a similar lactam (left compound in the pink box of Figure 1) was applied. After that, the synthesis of (-)-anaferine was accomplished in few steps, reducing the lactam to piperidine and oxidizing the 2-hydoxypropane bridge to the corresponding ketone. Chapter 5 deals with the synthesis of thiocolchicine-based bivalent compounds, possibly acting as microtubules binders. A hybrid compound, bearing the key structural features of pironetin (one of the few known α-tubulin binder), previously synthesised on our laboratory from 2-piperidine ethanol, was exploited as key building block. In fact, it was connected through different linkers to N-10-deacteyl-thiocolchicine, a model of β-tubulin binder. Biological tests revealed that the lipophilic nature of the linkers rendered our conjugates better substrates for P-glycoprotein, leading to a drop in activity on resistant cancer cells. Therefore, new bivalent compounds will be soon produced in our laboratory, changing linkers chemo-physical properties. Structures of the new compounds resulting from the expansion of the DOS-approach from 2-piperidine ethanol 1. Finally, chapter 6 concerned a project aimed at the generation of unnatural, diversified derivatives of lasalocid A and salinomycin, through feeding experiments of malonate-mimicking chemical probes to the natural Streptomyces producers, in an approach resembling mutasynthesis. The efforts were focused on the devopment of different strategies for an easier recovery and analysis of the unnatural products from the complex mixtures of the fermentation broths. To this extent, four chemical probes have been synthesised and proof on concept experiments were performed to verify their applicability in this field.
VASILEIADIS, SOTIRIOS. "Riflessione sugli effetti della diversità funzionale dei procarioti e della filogenesi dei suoli agricoli sui servizi ecosistemici. Approcci basati sull’uso di tecniche PCR nello studio dell’ecologia dei procarioti." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1313.
Повний текст джерелаSoil is a complex environment comprising the basis for several ecosystem services, with many of them being connected to agricultural production. This complexity is reflected on the composition and functions of the hosted microbial life mainly responsible for the acquired services. Aim of the described studies was to explore microbial community responses to ecosystem services related human intervention in agricultural soils. Total prokaryotic diversity was studied in soils of common origin, which diverged in properties during the late 6-7 centuries due to different land use and management. For achieving this, related DNA markers were screened with high throughput sequencing. Cultivated environments had increased diversity compared to more natural soils. Factors potentially affecting the microbial community structure were: soil disturbance events; available nutrients; and microbial dormancy. In a second approach, ammonia oxidizing prokaryotes were used as biomarkers for studying stress effects caused by humidity and increased zinc concentrations and also the presence of organic pesticides in soil and litter respectively. In both referred cases the studied microbial guilds responded to the applied stresses showing strain or taxon level functional redundancy potentials, and tolerance variability. Overall, results show that human intervention is determining for the prokaryotic structure and functions in agricultural soils.
VASILEIADIS, SOTIRIOS. "Riflessione sugli effetti della diversità funzionale dei procarioti e della filogenesi dei suoli agricoli sui servizi ecosistemici. Approcci basati sull’uso di tecniche PCR nello studio dell’ecologia dei procarioti." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1313.
Повний текст джерелаSoil is a complex environment comprising the basis for several ecosystem services, with many of them being connected to agricultural production. This complexity is reflected on the composition and functions of the hosted microbial life mainly responsible for the acquired services. Aim of the described studies was to explore microbial community responses to ecosystem services related human intervention in agricultural soils. Total prokaryotic diversity was studied in soils of common origin, which diverged in properties during the late 6-7 centuries due to different land use and management. For achieving this, related DNA markers were screened with high throughput sequencing. Cultivated environments had increased diversity compared to more natural soils. Factors potentially affecting the microbial community structure were: soil disturbance events; available nutrients; and microbial dormancy. In a second approach, ammonia oxidizing prokaryotes were used as biomarkers for studying stress effects caused by humidity and increased zinc concentrations and also the presence of organic pesticides in soil and litter respectively. In both referred cases the studied microbial guilds responded to the applied stresses showing strain or taxon level functional redundancy potentials, and tolerance variability. Overall, results show that human intervention is determining for the prokaryotic structure and functions in agricultural soils.
Dal, Fabbro Amedeo <1994>. "Caratterizzazione chimico-fisica di diversi supporti per la scrittura e loro interazione con inchiostro di galla in prove di invecchiamento simulato." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21230.
Повний текст джерелаBernardi, Tatiana <1970>. "Impiego della moderna cromatografia planare strumentale per lo studio dell'affinità di Bifidobacterium adolescentis MB239 per diversi substrati glucidi." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/639/1/Tesi_Bernardi_Tatiana.pdf.
Повний текст джерелаBernardi, Tatiana <1970>. "Impiego della moderna cromatografia planare strumentale per lo studio dell'affinità di Bifidobacterium adolescentis MB239 per diversi substrati glucidi." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/639/.
Повний текст джерелаBruno, Caterina <1987>. "Analisi di idrocarburi policiclici aromatici in campioni di particolato atmosferico (PM2.5) raccolti in diversi siti all'interno della Regione Veneto." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/3466.
Повний текст джерелаMenegaldo, Martina <1995>. "Analisi comparativa di diversi scenari di gestione dei rifiuti provenienti da attività di bonifica di siti contaminati attraverso un approccio LCA." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19226.
Повний текст джерелаЧастини книг з теми "Chimical Diversity"
Rosi, Fabiana. "The Other Side of the Moon: Content-Specific Learning in CLIL in Core and Non-Core Subjects." In La linguistica educativa tra ricerca e sperimentazione Scritti in onore di Carmel Mary Coonan. Venice: Fondazione Università Ca’ Foscari, 2023. http://dx.doi.org/10.30687/978-88-6969-683-1/017.
Повний текст джерела