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Rozprawy doktorskie na temat „Antitumoral properties”

Autor: Grafiati

Data publikacji: 19 października 2024

Data aktualizacji: 31 lipca 2025

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1

Panosa, Roqueta Clara. "Antitumoral properties of epidermal growth factor derivatives." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/369050.

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The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that inactivate the ErbB receptors through novel strategies is an important goal on cancer research. In this thesis work we have developed a shorter form of human EGF (EGFt) with a truncated C-terminal as a novel EGFR inhibitor. EGFt was designed based on the superimposition of the three-dimensional structures of EGF and the Potato Carboxypeptidase Inhibitor (PCI), an EGFR blocker pr

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Tonello, Andrea <1988&gt. "Synthesis and Engineering of PLGA-based Nanoparticles with antitumoral Properties." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/5394.

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Nano-based delivery systems have attracted a great deal of attention in the past two decades as a strategy to overcome the low therapeutic index of conventional anticancer drugs. Nanoparticles enable the delivery of a great variety of drugs including analgesics, anti-Alzheimer's drugs, cardiovascular drugs, and several macromolecules into the brain after intravenous injection of animals. The mechanism of nanoparticle-mediated drug transport across the blood-brain barrier appears to be receptor-mediated endocytosis followed by drug release within the endothelial cells. Modification of the nanop

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3

Zou, Yu. "Dendrimères et dendrons phosphorés : synthèse, propriétés et applications en nanomédecine." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES093.

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L'objectif de ce travail de thèse a été de préparer de nouveaux dendrimères ou dendrons phosphorés, qu'ils soient neutres, cationiques ou anioniques, dans le but d'élargir le panel des applications dans le domaine de la nanomédecine en tant que molécules actives par elles-mêmes ou en association avec certains médicaments. Au chapitre 1, la synthèse d'un nouveau dendrimère phosphoré polycationique comportant en surface 5 groupements pyrrolidinium et une amine protonnée a été menée à bien. Ce dendrimère associé au microRNA-30d permet d'obtenir des polyplexes qui sont transférés dans les cellules

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Salvador, Cátia Sofia Clemente. "Caracterização de cogumelos silvestres da espécie Amanita ponderosa: produção de metabolitos com atividade biológica." Doctoral thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/13391.

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Amanita ponderosa é uma espécie de cogumelos silvestres, comestível, característica de alguns microclimas mediterrânicos, existente na Península Ibérica. Neste estudo, avaliaram-se as propriedades biológicas e toxicológicas destes cogumelos e culturas, com vista a valorizar o seu potencial biotecnológico. Desenvolveu-se também uma metodologia de monitorização, utilizando técnicas de microanálise e imunológicas para screening e análise da especificidade de produção dos compostos bioativos. Os corpos de frutificação apresentaram um relevante conteúdo mineral e um perfil molecular correlacionável

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5

Brink, Susanna. "Structure-activity relationships of titanocene complexes with antitumor properties." Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09052005-101713/.

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6

Chen, Chujian 1966. "Antitumor properties of kefir : possible bioactive component(s) and mechanism(s)." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85139.

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Research on the putative health benefits has indicated that kefir, a traditional fermented milk, might have antimutagenic and antitumor properties. The major objective of the present thesis was to isolate and identify antitumor compounds in cow's milk kefir and investigate the possible mechanisms involved. High speed centrifugation (HSC), molecular weight cut-off filtration (MWCO), size exclusion high performance liquid chromatography (SEC-HPLC) and reverse phase-HPLC (RP-HPLC) were utilized for fractionation of kefir and a cell culture model was developed to screen for the antiprolifer

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7

Sun, Wai-yin Raymond, and 辛偉賢. "The antitumor and antiviral properties of gold (III) porphyrins and their related complexes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31245973.

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8

Zhang, Zhouen. "Tumor-targeting antitumor prodrugs and noninvasive molecular imaging probes : designs, syntheses and properties." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/144557.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第11886号<br>工博第2579号<br>新制||工||1361(附属図書館)<br>23666<br>UT51-2005-N720<br>京都大学大学院工学研究科物質エネルギー化学専攻<br>(主査)教授西本清一, 教授中條善樹, 教授木村俊作<br>学位規則第4条第1項該当

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9

BUSA', Rosalia. "Evaluation of antitumor and immunomodulatory properties of Indicaxanthin from Opuntia Ficus Indica (L. Mill) fruit." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395264.

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Cancer is a growing health problem around the world and according to estimates from the International Agency for Research on Cancer (IARC), 14.1 million new cancer cases and 8.2 million cancer deaths worldwide have been reported in 2012 (Ferlay et al., 2015). By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Indicaxanthin ((2S)-2,3-dihydro-4-[2-[(2S)-2a-carboxypyrrolidin-1- yl]ethenyl]pyridine-2a,6-dicarboxylic acid), a betalain pigment from cactus pear fruit, has been the object o

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10

Medvetz, Douglas Allen. "The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371.

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11

Knapp, Amanda R. "Antimicrobial and Antitumor Properties of Free and Poly(Ethylene Glycol)-Poly(Lactic Acid) Encapsulated Silver N-Heterocyclic Carbene Complexes." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1309211795.

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12

Goubau, Delphine. "Distinct roles of interferon regulatory factor (IRF)-3 and IRF-7 in the activation of the antitumor properties of human macrophages." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18752.

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The interferon (IFN) regulatory factors (IRF) are transcriptional mediators of the cellular innate immune defense. Two of these factors, IRF-3 and IRF-7, are the principal inducers of type I IFN (IFN-alpha and -beta), which are key players in the antiviral response. Type I IFNs also exert strong antiproliferative and antiangiogenic effects and are widely used as adjuvants for therapy against cancer. When properly activated, macrophages can be tumoricidal making them attractive additions to standard cancer therapies. To this end, tolerance and activity of human autologous IFN-gamma-activated ma

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13

Strioga, Marius. "Expression of biomarkers, representing immunosuppressive, cytotoxic or immunomodulating properties of CD8h T lymphocytes in the peripheral blood of patients with immunogenic cancer forms." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105111-42651.

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The aim of the study was to evaluate the expression of immunosuppressive (FOXP3, NKG2A), and cytotoxic (perforin) or cytotoxic / immunomodulating (IFNγ) T-cell properties representing biomarkers in the peripheral blood CD8h T-cell population of patients with advanced renal cell carcinoma (RCC) or high risk cutaneous melanoma and healthy controls by multicolour flow cytometry. Determination of the percentage of functionally competing T-cell subsets (especially immunosuppressive) in the CD8hCD57+ T-cell subpopulation in future may serve as one of parameters enabling to assess the overall status

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14

Saha, Chaitrali. "Unravelling the therapeutic intervention of inflammation and cancer by Viscum album : understanding its anti-inflammatory and immunostimulatory properties." Thesis, Compiègne, 2015. http://www.theses.fr/2015COMP2210/document.

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Les préparations de Viscum album (VA), connu sous le nom vernaculaire de gui européen, sont fréquemment utilisées en support des traitements anticancéreux, principalement pour améliorer la qualité de vie des malades et réduire la croissance des tumeurs. Elles sont connues pour exercer des effets anti-tumoraux. Il existe de plus en plus de données scientifiques faisant état de liens étroits entre cancer et inflammation. Étant donné que la prostaglandine E2 (PGE2) induite par la cyclo-oxygénase 2 (COX-2) joue un rôle clef dans l’inflammation, j’ai exploré la régulation du système COX-2-PGE2 par

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15

Glorani, Giulia. "Structural studies of a Tremella fuciformis mushroom lectin: a novel protein with antitumoral properties." Doctoral thesis, 2019. http://hdl.handle.net/11562/994597.

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Lectins are carbohydrate-binding proteins of non-immune origin, widely distributed in all the living organisms. They play a role in different biological processes and, due to their carbohydrate specific binding, some lectins have been found to possess antitumoral properties. A particular case is the recognition of the T-antigenic determinant (Galβ1-3GalNAcα) on the malignant cell surfaces, which is present in 90% of human carcinomas. Upon binding to the carbohydrate, some lectins can cause apoptosis, cytotoxicity, inhibition of tumour growth, thus preventing the proliferation of tumoral cells.

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16

Brink, Susanna. "Structure-activity relationship of titanocene complexes with antitumor properties." Thesis, 2003. http://hdl.handle.net/2263/27746.

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Oyun-Enkh and 歐優娜˙龐扎克. "The induction of apoptosis and antitumor properties of Mongolian plants." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/75391887780018879682.

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博士<br>中山醫學大學<br>牙醫學系碩士班<br>99<br>Euphorbia Fisheriana Steudal (EF) and Saussurea Involucrata (SI) are rare plants which were used in ancient Eastern medicine. In this study, the antitumor properties of EF and SI were assessed by MTT assay, Western immunobloting, DNA fragmentation and nuclei staining methods. We have found that both of the plant extracts promote the apoptotic death of tumor cells by activation of proapoptotic regulators of Bcl-2 family and MAPK pathway, especially SAPK/JNK2. In case when EF was employed, the initiation of apoptosis was linked to the activation of intrinsic pat

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18

Song, Tuzz-Ying, and 宋祖瑩. "Studies on Antioxidant and Antitumor Properties of Antrodia camphorata in Submerged Culture." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/23404381735808384640.

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博士<br>國立中興大學<br>食品科學系<br>91<br>This study evaluated antioxidant and Anti-tumor properties of extracts from Antrodia camphorata in submerged culture (ACSC). Chapter 2 focuses on the studies of biologically active compounds and the antioxidant activity as well as free radical scavenging effects of dry matter of cultural medium (DMCM), filtrate (DMF) and different solvent extracts of mycelia from Antrodia camphorata in submerged culture (ACSC). DMF showed the strongest inhibition of lipid peroxidation as a function of its concentration, and was comparable to the antioxidant activity of BHA at t

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19

Grau, L., M. Romero, C. Privat-Contreras, et al. "Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties." 2019. http://hdl.handle.net/10454/17526.

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Yes<br>An efficient four-step synthesis of tetracyclic lactones from 1,4-benzodioxine-2-carboxylic acid was developed. Ellipticine derivatives exhibit antitumor activity however only a few derivatives without carbazole subunit have been studied to date. Herein, several tetracyclic lactones were synthesized and biologically evaluated. Several compounds (2a, 3a, 4a and 5a) were found to be inhibitors of the Kras-Wnt pathway. The lactone 2a also exerted a potent inhibition of Tau protein translation and was shown to have capacity for CYP1A1-bioactivation. The results obtained are further evidence

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20

Liu, Hsiu-Wen, and 劉秀雯. "In vitro and in vivo antitumor properties of Antrodia salmonea against human colon cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/83szz8.

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Catarino, Marcelo Dias. "Fucus vesiculosus phlorotannins: extraction, structural characterization and effects throughout the gastrointestinal tract." Doctoral thesis, 2021. http://hdl.handle.net/10773/31275.

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Marine macroalgae have a long tradition of usage and applications among the far Eastern populations, either for direct consumption and nutrition or for medicinal purposes. During the recent years, these marine organisms have received increasing popularity among the Western populations which are becoming aware of their potential to be exploited as a source of valuable bioactive compounds. Among these compounds are the phlorotannins, which are a group of phloroglucinol-derived phenolic compounds occurring exclusively on brown seaweeds and claimed for their promising health-promoting

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22

Heleno, Sandrina Alves. "Important human metabolites of phenolic acids from diet with wild mushrooms: chemical synthesis and studies of their antioxidant, antitumor and antimicrobial properties." Doctoral thesis, 2014. http://hdl.handle.net/1822/35721.

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Tese de doutoramento em Ciências (ramo de conhecimento em Química)<br>In this study, seven wild mushroom species (Ganoderma lucidum, Coprinopsis atramentaria, Rhodotus palmatus, Lactarius bertillonii, Lactarius vellereus, Xerocomus chrysenteron and Morchella esculenta), were characterized for their nutritional value (macronutrients and energy) and chemical composition (fatty acids, tocopherols, sugars and organic acids). A special focus was given to the analysis of phenolic acids and related compounds in mushroom fruiting bodies, spores and in vitro produced mycelia, by using chromatographic a

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23

Guimarães, Cristina Rafaela dos Santos Albuquerque. "Towards antioxidant and antitumor properties of wild medicinal plants traditionally used in Portugal: extracts, isolated flavonoids, and their human metabolites obtained by chemical synthesis." Doctoral thesis, 2016. http://hdl.handle.net/1822/41853.

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Tese de Doutoramento em Ciências (Especialidade em Química)<br>According their empirical relevance in traditional medicine and diets, six wild species from the Portuguese medicinal flora were selected as important sources of phenolic compounds, namely flavonoids. The present study aimed to characterize the phenolic composition and evaluate bioactive properties (antioxidant, antitumor and antiangiogenic) of methanolic extracts, infusions and decoctions prepared from Chamaemelum nobile and Matricaria recutita, and Prunus spinosa, Arbutus unedo, Rosa micrantha and Rosa canina fruits; and to

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24

柯宏儒. "Modification of Roussin’s Red Esters by Incorporation of α-Lipoic Acid Conjugated with Poly(ethylene glycol) for the Study of Photochemical Properties and Antitumor Activity". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/25825472118679886221.

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碩士<br>國立嘉義大學<br>應用化學系研究所<br>101<br>Abstract Here, we synthesize two new Roussin’s Red Esters (RREs) : RRE(ALA-TEG) (1) and RRE(ALA-PEG400) (2). These complexes have used IR, EA and TEM to prove their comformation and micelle form. We have also used NO analyer to demonstrate complexes (1) and (2) that can released NO by UV. In addition, we demonstrated that NO can cleavage DNA in direct proportion to its concentration.

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25

Mouffok, Kheira Moufida. "Quality evaluation and biological properties of Algerian commercial honeys labeled as Rosemary, Tamarisk, Thistle and multiflora." Master's thesis, 2020. http://hdl.handle.net/10198/24074.

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Mestrado de dupla diplomação com a Université Moulay Taher<br>Honey is considered a natural sweet substance produced by honeybees, from the nectars of plant flowers and honeydews. Honey has always been regarded as a food that is beneficial for human health with several therapeutic qualities described. The quality of honey is still a top concern for experts as no good method has been defined so far for the simultaneous detection of different types of honey. Consequently, the development of easy, quick, precise analytical tools that may give data for assessing honey authenticity, is important. B

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