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Artykuły w czasopismach na temat „Antitumoral properties”

Autor: Grafiati

Data publikacji: 19 października 2024

Data aktualizacji: 31 lipca 2025

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1

Fabiani, Roberto. "Antitumoral Properties of Natural Products." Molecules 25, no. 3 (2020): 650. http://dx.doi.org/10.3390/molecules25030650.

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McLachlan, J. A., C. D. Serkin, K. M. Morrey, and O. Bakouche. "Antitumoral properties of aged human monocytes." Journal of Immunology 154, no. 2 (1995): 832–43. http://dx.doi.org/10.4049/jimmunol.154.2.832.

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Abstract It is known that older people are more sensitive to cancer and infectious agents and need more time to recover from such disorders. Can this difference in sensitivity to cancer and infections between elderly and younger people be a result of a difference in their immune systems and, more specifically, in the way monocytes react to infectious agents and cancer cells? To determine what happens after cells have aged, human monocytes were purified from young donors (approximately 25 years of age) and from older donors (65 years of age or older) and tested for their ability to respond to t

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Braca, A. "Insight on antitumoral properties of plant diterpenes." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596105.

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Pandiella-Alonso, Atanasio, Elena Díaz-Rodríguez, and Eduardo Sanz. "Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review." Nutrients 12, no. 9 (2020): 2661. http://dx.doi.org/10.3390/nu12092661.

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Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell prolife

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Lungu, Claudiu N., Bogdan Ionel Bratanovici, Maria Mirabela Grigore, Vasilichia Antoci, and Ionel I. Mangalagiu. "Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators." Current Medicinal Chemistry 27, no. 1 (2020): 154–69. http://dx.doi.org/10.2174/0929867326666181220094229.

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Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was deve

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Iacopetta, Domenico, Jessica Ceramella, Alessia Catalano, et al. "Schiff Bases: Interesting Scaffolds with Promising Antitumoral Properties." Applied Sciences 11, no. 4 (2021): 1877. http://dx.doi.org/10.3390/app11041877.

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Schiff bases, named after Hugo Schiff, are highly reactive organic compounds broadly used as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. Lots of Schiff bases are described in the literature for various biological activities, including antimalarial, antibacterial, antifungal, anti-inflammatory, and antiviral. Schiff bases are also known for their ability to form complexes with several metals. Very often, complexes of Schiff bases with metals and Schiff bases alone have demonstrated interesting antitumor activity. Given the innumerable vastness of d

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Perez-Tomas, R., and M. Vinas. "New Insights on the Antitumoral Properties of Prodiginines." Current Medicinal Chemistry 17, no. 21 (2010): 2222–31. http://dx.doi.org/10.2174/092986710791331103.

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Esteruelas, Gerard, Eliana B. Souto, Marta Espina, et al. "Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy." Pharmaceutics 15, no. 1 (2022): 102. http://dx.doi.org/10.3390/pharmaceutics15010102.

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Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulat

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Adam, Gigi, Florina Daniela Cojocaru, Liliana Verestiuc, et al. "Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Perilla leaves Extracts." Antioxidants 13, no. 1 (2023): 58. http://dx.doi.org/10.3390/antiox13010058.

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(1) Background: This study aimed to outline the antioxidant, antitumoral, and cytotoxic proprieties of various types of Perilla frutescens extracts obtained from the leaves of the species. (2) Methods: We determined total polyphenols, flavonoids and anthocyanins contents, as well as the in vitro antioxidant, antitumoral, and cytotoxic actions in three types of ethanolic extracts (E1, E2, E3) and in three types of acetone: ethanol extracts (A1, A2, A3) of Perilla frutescens according to standardized procedures. (3) Results: We found that Perilla frutescens ethanolic extracts had the highest tot

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Nava-Villalba, Mario, and Carmen Aceves. "6-Iodolactone, key mediator of antitumoral properties of iodine." Prostaglandins & Other Lipid Mediators 112 (August 2014): 27–33. http://dx.doi.org/10.1016/j.prostaglandins.2014.07.001.

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Klaiss-Luna, Maria C., Juan M. Giraldo-Lorza, Małgorzata Jemioła-Rzemińska, Kazimierz Strzałka, and Marcela Manrique-Moreno. "Biophysical Insights into the Antitumoral Activity of Crotalicidin against Breast Cancer Model Membranes." International Journal of Molecular Sciences 24, no. 22 (2023): 16226. http://dx.doi.org/10.3390/ijms242216226.

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Bioactive peptides have emerged as promising therapeutic agents with antimicrobial, antifungal, antiparasitic, and, recently, antitumoral properties with a mechanism of action based on membrane destabilization and cell death, often involving a conformational change in the peptide. This biophysical study aims to provide preliminary insights into the membrane-level antitumoral mode of action of crotalicidin, a cationic host defense peptide from rattlesnake venom, toward breast cancer cell lines. The lipid composition of breast cancer cell lines was obtained after lipid extraction and quantificat

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Sánchez-Quesada, Cristina, Francisco Gutiérrez-Santiago, Carmen Rodríguez-García, and José J. Gaforio. "Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells." Nutrients 14, no. 2 (2022): 255. http://dx.doi.org/10.3390/nu14020255.

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Several studies relate Mediterranean diet and virgin olive oil (VOO) intake with lower risk of several chronic diseases, including breast cancer. Many of them described antitumor properties of isolated minor compounds present in VOO, but beneficial properties of VOO arise from the effects of all its compounds acting together. The aim of the present study was to test the antitumor effects of two minor compounds from VOO (hydroxytyrosol (HT) and squalene (SQ)) on highly metastatic human breast tumor cells (MDA-MB-231) when acting in combination. Both isolated compounds were previously analyzed w

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Kozlova, A. I., E. V. Voropayev, and A. I. Konoplya. "THE ROLE OF DENDRITIC CELLS IN FORMATION OF ANTITUMORAL IMMUNITY (literature review)." Health and Ecology Issues, no. 4 (December 28, 2014): 19–24. http://dx.doi.org/10.51523/2708-6011.2014-11-4-3.

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At present, dendritic cells are thought to be the main «professional» antigenpresenting cells. They play the leading role in the triggering of the adaptive immune response and its integration with inborn immunity. These properties of dendritic cells determine significant interest for their possible use as a base for making antitumoral vaccines. The results of the study testify about the amplification of the lymphocytes antitumoral activity in relation to the types of tumors against which DC-vaccination was carried out.

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Miranda-Vera, Carolina, Ángela-Patricia Hernández, Pilar García-García, David Díez, Pablo A. García, and María Ángeles Castro. "Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile." Pharmaceuticals 18, no. 2 (2025): 169. https://doi.org/10.3390/ph18020169.

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Podophyllotoxin is a natural compound belonging to the lignan family and is well-known for its great antitumor activity. However, it shows several limitations, such as severe side effects and some pharmacokinetics problems, including low water solubility, which hinders its application as an anticancer agent. Over the past few years, antitumor research has been focused on developing nanotechnology-based medicines or nanomedicines which allow researchers to improve the pharmacokinetic properties of anticancer compounds. Following this trend, podophyllotoxin nanoconjugates have been obtained to o

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15

Diez, Marta Martínez, María José Muñoz-Alonso, Gema Santamaría Nuñez, et al. "Abstract 6243: The novel antitubulin agent PM534 exhibits potent antitumoral and antiangiogenic properties in vitro and in vivo." Cancer Research 83, no. 7_Supplement (2023): 6243. http://dx.doi.org/10.1158/1538-7445.am2023-6243.

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Abstract Background: Microtubule targeting agents have demonstrated to be very effective antitumoral drugs. The development of novel anti-tubulin agents with more efficient mechanisms of action presents several challenges due to their poor solubility, troublesome synthesis or purification, and toxicities. In this work, we present the novel anti-tubulin agent PM534, a synthetic small molecule that shows efficient antitumoral and antiangiogenic properties in vitro and in vivo. Methods and Results: PM534 exhibits a potent antitumor activity in vitro with a mean GI50 value in the low nanomolar ran

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Mašković, Jelena M., Antonios Hatzidimitriou, Ana Damjanović, et al. "Synthesis, characterization and biological evaluation of Pd(ii), Cu(ii), Re(i) and 99mTc(i) thiazole-based complexes." MedChemComm 9, no. 5 (2018): 831–42. http://dx.doi.org/10.1039/c8md00067k.

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Wang, Xiaohong, Jianxin Li, Jianghua He, and Jingfu Liu. "Synthesis, Properties and Biological Activity of Organotitanium Substituted Heteropolytungstates." Metal-Based Drugs 8, no. 4 (2001): 179–82. http://dx.doi.org/10.1155/mbd.2001.179.

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Six new compounds [(CpTi)XW11O39]n− (Cp=η5-C5H5, X=Ge, Ga, B) have been prepared and their Keggin structures determined by elementary analysis, IR, UV, H1 NMR and W183 NMR spectrometry. The results show that the complexes retain Keggin structure. The complexes exhibit antitumoral activity in vitro as shown by MTT experiment.

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18

Măciucă, Ana-Mădălina, Mihaela Badea, Rodica Olar, Alexandra Cristina Munteanu, and Valentina Uivarosi. "Synthesis and Physico-Chemical Characterization of the Cu(II), Pd(II) and Ru(III) Complexes with Difloxacin." Proceedings 29, no. 1 (2019): 65. http://dx.doi.org/10.3390/proceedings2019029065.

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The growing interest in metal-quinolone complexes is sustained by a large number of compounds obtained and tested for antibacterial [1], antitumoral [1,2], antifungal [1], and antiparasitic [3] properties. [...]

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19

Sanchez-Martin, Victoria, María del Carmen Plaza-Calonge, Ana Soriano-Lerma, et al. "Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes." Cancers 14, no. 11 (2022): 2648. http://dx.doi.org/10.3390/cancers14112648.

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Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in a cellular model of colorectal cancer (CRC). We selected gallic acid (GA) as a candidate in terms of potency and selectivity and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional inhibition of ribosomal

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Kalechman, Y., A. Shani, S. Dovrat, et al. "The antitumoral effect of the immunomodulator AS101 and paclitaxel (Taxol) in a murine model of lung adenocarcinoma." Journal of Immunology 156, no. 3 (1996): 1101–9. http://dx.doi.org/10.4049/jimmunol.156.3.1101.

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Abstract The immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate (AS101) has been shown to possess antitumoral properties in several murine models. In the present study, we demonstrate a synergistic in vivo antitumor effect of AS101 and Taxol against early stage Madison 109 lung adenocarcinoma. Treatment with optimal doses of Taxol (25 and 17 mg/kg) and AS101 (0.5 mg/kg) resulted in 66.6 and 43.3% cures. We propose that the antitumor effect is the result of both a direct and indirect effect of the drugs on tumor cells. AS101 and Taxol directly inhibited clonogenicity of M109 cells

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Cudalbeanu, Mihaela, Bianca Furdui, Geta Cârâc, et al. "Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts." Antibiotics 9, no. 1 (2019): 7. http://dx.doi.org/10.3390/antibiotics9010007.

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This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory effect on wheat seed germination by evaluating the most sensitive physiological parameters (Germination %, Germination index, Vigor index) and using confocal laser scanning microscopy images. The analyzed extracts were found to have high antifungal activity against Candida glabrata with MIC values of 1.717 µg/mL for leaf and 1.935 µg/mL for

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Pérez-Peña, Javier, Elena Díaz-Rodríguez, Eduardo Sanz, and Atanasio Pandiella. "Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin." Nutrients 11, no. 5 (2019): 1068. http://dx.doi.org/10.3390/nu11051068.

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Nutritional supplements which include natural antitumoral compounds could represent safe and efficient additives for cancer patients. One such nutritional supplement, Ocoxin Oral solution (OOS), is a composite formulation that contains several antioxidants and exhibits antitumoral properties in several in vitro and in vivo tumor conditions. Here, we performed a functional genomic analysis to uncover the mechanism of the antitumoral action of OOS. Using in vivo models of acute myelogenous leukemia (AML, HEL cells, representative of a liquid tumor) and small-cell lung cancer (GLC-8, representati

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Azar, Fadi, Jules Deforges, Christelle Demeusoit, et al. "TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment." Journal for ImmunoTherapy of Cancer 12, no. 7 (2024): e009302. http://dx.doi.org/10.1136/jitc-2024-009302.

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BackgroundTG6050 was designed as an improved oncolytic vector, combining the intrinsic properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted expression of recombinant immune effectors to modify the tumor immune phenotype. These properties might be of particular interest for “cold” tumors, either poorly infiltrated or infiltrated with anergic T cells.Methods TG6050, an oncolytic vaccinia virus encodes single-chain human interleukin-12 (hIL-12) and full-length anti-cytotoxic T-lymphocyte-associated antigen-4 (@CTLA-4) monoclonal antibody. The relevant properti

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Sin, Zi Wayne, Vipul Bhardwaj, Amit Kumar Pandey, and Manoj Garg. "A brief overview of antitumoral actions of bruceine D." Exploration of Targeted Anti-tumor Therapy 1, no. 4 (2020): 200–217. http://dx.doi.org/10.37349/etat.2020.00013.

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Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient’s lives. As such, natural bioactive compounds have gained an attraction in the scientific and medical community as evidence of their anticancer properties and attenuation of side effects mounted. In particular, quassinoids have been found to exhibit a plethora of inhibitory activities such as anti-proliferative effects on tumo

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Pérez-Larrán, Patricia, Elena M. Balboa, María Dolores Torres, and Herminia Domínguez. "Antioxidant and Antitumoral Properties of Aqueous Fractions from Frozen Sargassum muticum." Waste and Biomass Valorization 11, no. 4 (2018): 1261–69. http://dx.doi.org/10.1007/s12649-018-0456-x.

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Williams, Patricia A. M., Juan Zinczuk, Daniel A. Barrio, Oscar E. Piro, Otaciro R. Nascimento, and Susana B. Etcheverry. "Potential antitumoral properties of a new copper complex with santonic acid." Bioorganic & Medicinal Chemistry 16, no. 8 (2008): 4313–22. http://dx.doi.org/10.1016/j.bmc.2008.02.075.

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Bento, Ananda de Araujo, Marianna Cardoso Maciel, Francisco Felipe Bezerra, Paulo Antônio de Souza Mourão, Mauro Sérgio Gonçalves Pavão, and Mariana Paranhos Stelling. "Extraction, Isolation, Characterization, and Biological Activity of Sulfated Polysaccharides Present in Ascidian Viscera Microcosmus exasperatus." Pharmaceuticals 16, no. 10 (2023): 1401. http://dx.doi.org/10.3390/ph16101401.

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Ascidians are marine invertebrates that synthesize sulfated glycosaminoglycans (GAGs) within their viscera. Ascidian GAGs are considered analogues of mammalian GAGs and possess great potential as bioactive compounds, presenting antitumoral and anticoagulant activity. Due to its worldwide occurrence and, therefore, being a suitable organism for large-scale mariculture in many marine environments, our main objectives are to study Microcosmus exasperatus GAGs regarding composition, structure, and biological activity. We also aim to develop efficient protocols for sulfated polysaccharides extracti

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Rodriguez, Lucía Ines Lopez, Roberto Amadio, Giulia Maria Piperno, and Federica Benvenuti. "Tissue-specific properties of type 1 dendritic cells in lung cancer: implications for immunotherapy." Journal for ImmunoTherapy of Cancer 13, no. 3 (2025): e010547. https://doi.org/10.1136/jitc-2024-010547.

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Checkpoint inhibitors have led to remarkable benefits in non-small cell lung cancer (NSCLC), yet response rates remain below expectations. High-dimensional analysis and mechanistic experiments in clinical samples and relevant NSCLC models uncovered the immune composition of lung cancer tissues, providing invaluable insights into the functional properties of tumor-infiltrating T cells and myeloid cells. Among myeloid cells, type 1 conventional dendritic cells (cDC1s) stand out for their unique ability to induce effector CD8 T cells against neoantigens and coordinate antitumoral immunity. Notabl

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Stockert, J. C., M. Cañete, A. Villanueva, A. Juarranz, C. I. Trigoso, and M. F. Braña. "Fluorescence of Chromatin DNA Induced by Antitumoral Naphthalimides." Zeitschrift für Naturforschung C 52, no. 5-6 (1997): 408–12. http://dx.doi.org/10.1515/znc-1997-5-621.

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Abstract Treatment of chicken blood smears and semithin sections from Epon-embedded mouse tissues with aqueous solutions of the 3-aminonaphthalimides FA-142, FA-2043, and FA-2143 induced a strong green-yellow fluorescence of chromatin under violet or violet-blue excitation. Chromatin emission was abolished by previous DNase or hot TCA treatment. The use of 3-methoxy (FA-655) and 3-nitro derivatives (M-4212 and M-12210) resulted in very weak fluorescence of chromatin. Absorption maxima at 346 and 408 nm and an emission peak at 570 nm were observed for the free compound FA-142. Fluorescence pr

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Jin, Xi-Feng, Gerald Spöttl, Julian Maurer, Svenja Nölting та Christoph Josef Auernhammer. "Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors In Vitro: Antitumoral Effects". Cancers 12, № 2 (2020): 345. http://dx.doi.org/10.3390/cancers12020345.

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Background and aims: Inhibition of Wnt/β-catenin signaling by specific inhibitors is currently being investigated as an antitumoral strategy for various cancers. The role of Wnt/β-catenin signaling in neuroendocrine tumors still needs to be further investigated. Methods: This study investigated the antitumor activity of the porcupine (PORCN) inhibitor WNT974 and the β-catenin inhibitor PRI-724 in human neuroendocrine tumor (NET) cell lines BON1, QGP-1, and NCI-H727 in vitro. NET cells were treated with WNT974, PRI-724, or small interfering ribonucleic acids against β-catenin, and subsequent an

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Felthaus, Oliver, Simon Vedlin, Andreas Eigenberger, Silvan M. Klein, and Lukas Prantl. "Exosomes from Adipose-Tissue-Derived Stem Cells Induce Proapoptotic Gene Expression in Breast Tumor Cell Line." International Journal of Molecular Sciences 25, no. 4 (2024): 2190. http://dx.doi.org/10.3390/ijms25042190.

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Lipofilling is an option for breast reconstruction after tumor resection to avoid the complications of an implant-based reconstruction. Although some concerns exist regarding the oncological safety of tissue rich in mesenchymal stem cells with their proangiogenic and proliferation-supportive properties, there are also reports that adipose-tissue-derived stem cells can exhibit antitumoral properties. We isolated primary adipose-tissue-derived stem cells. Both conditioned medium and exosomes were harvested from the cell culture and used to treat the breast cancer cell line MCF-7. Cell viability,

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Calvo-Martín, Gorka, Daniel Plano, Nuria Martínez-Sáez, et al. "Norbornene and Related Structures as Scaffolds in the Search for New Cancer Treatments." Pharmaceuticals 15, no. 12 (2022): 1465. http://dx.doi.org/10.3390/ph15121465.

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The norbornene scaffold has arisen as a promising structure in medicinal chemistry due to its possible therapeutic application in cancer treatment. The development of norbornene-based derivatives as potential chemotherapeutic agents is attracting significant attention. Here, we report an unprecedented review on the recent advances of investigations into the antitumoral efficacy of different compounds, including the abovementioned bicyclic scaffold in their structure, in combination with chemotherapeutic agents or forming metal complexes. The impact that structural modifications to these bicycl

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Wang, Edina, Maria Alba Sorolla, Priya Darshini Gopal Krishnan, and Anabel Sorolla. "From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds." Biomolecules 10, no. 2 (2020): 248. http://dx.doi.org/10.3390/biom10020248.

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioa

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Rigon, Roberta Balansin, Márcia Helena Oyafuso, Andressa Terumi Fujimura, et al. "Nanotechnology-Based Drug Delivery Systems for Melanoma Antitumoral Therapy: A Review." BioMed Research International 2015 (2015): 1–22. http://dx.doi.org/10.1155/2015/841817.

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Melanoma (MEL) is a less common type of skin cancer, but it is more aggressive with a high mortality rate. The World Cancer Research Fund International (GLOBOCAN 2012) estimates that there were 230,000 new cases of MEL in the world in 2012. Conventional MEL treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties. Drug delivery systems are an alternative strategy by which to carry antineoplastic agents. Encapsulated drugs are advantageous due to such properties as high stability, better bioavailability, controlled drug release, a

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Kraus, J., W. Blaschek та G. Franz. "Antitumoral and Immunological Properties of a β-1,3/1,6-Glucan fromPhytophthora parasitica". Planta Medica 54, № 06 (1988): 565. http://dx.doi.org/10.1055/s-2006-962565.

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Nocentini, G., F. Federici, M. Grifantini, and A. Barzi. "Copper complex of a new ribonucleotide reductase inhibitor characterized by antitumoral properties." Pharmacological Research 25 (May 1992): 312–13. http://dx.doi.org/10.1016/1043-6618(92)90421-7.

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Hernández, Ángela-Patricia, Laura Iglesias-Anciones, José Javier Vaquero-González, et al. "Enhancement of Tumor Cell Immunogenicity and Antitumor Properties Derived from Platinum-Conjugated Iron Nanoparticles." Cancers 15, no. 12 (2023): 3204. http://dx.doi.org/10.3390/cancers15123204.

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From chemistry design to clinical application, several approaches have been developed to overcome platinum drawbacks in antitumoral therapies. An in-depth understanding of intracellular signaling may hold the key to the relationship of both conventional drugs and nanoparticles. Within these strategies, first, nanotechnology has become an essential tool in oncotherapy, improving biopharmaceutical properties and providing new immunomodulatory profiles to conventional drugs mediated by activation of endoplasmic reticulum (ER) stress. Secondly, functional proteomics techniques based on microarrays

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Formagio, ASN, DD Ramos, MC Vieira, et al. "Phenolic compounds of Hibiscus sabdariffa and influence of organic residues on its antioxidant and antitumoral properties." Brazilian Journal of Biology 75, no. 1 (2015): 69–76. http://dx.doi.org/10.1590/1519-6984.07413.

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The aim of this study was to evaluate the phenolic and flavonoids contents and the antioxidant and antitumoral activity of leaf and calyx methanolic extracts from Hibiscus sabdariffa (roselle) cultivated with poultry litter and organosuper® under three modes of application. The total phenolic content in the each extract was determined using the Folin-Ciocalteu reagent and for aluminium chloride flavonoids. The antioxidant parameters were analyzed using a 2, 2-diphenyl-1-picrylhydrazyl (DPPH.) free radical scavenging assay. An antitumor colorimetric assay using sulforhodamine B. The highest con

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Martínez-Iglesias, Olaia, Ivan Carrera, Vinogran Naidoo, and Ramón Cacabelos. "AntiGan: An Epinutraceutical Bioproduct with Antitumor Properties in Cultured Cell Lines." Life 12, no. 1 (2022): 97. http://dx.doi.org/10.3390/life12010097.

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Novel and effective chemotherapeutic agents are needed to improve cancer treatment. Epidrugs are currently used for cancer therapy but also exhibit toxicity. Targeting the epigenetic apparatus with bioproducts may aid cancer prevention and treatment. To determine whether the lipoprotein marine extract AntiGan shows epigenetic and antitumor effects, cultured HepG2 (hepatocellular carcinoma) and HCT116 (colorectal carcinoma) cell lines were treated with AntiGan (10, 50, 100, and to 500 µg/mL) for 24 h, 48 h, and 72 h. AntiGan (10 µg/mL) reduced cell viability after 48 h and increased Bax express

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González-Ballesteros, Noelia, Immacolata Maietta, Raquel Rey-Méndez, et al. "Gold Nanoparticles Synthesized by an Aqueous Extract of Codium tomentosum as Potential Antitumoral Enhancers of Gemcitabine." Marine Drugs 21, no. 1 (2022): 20. http://dx.doi.org/10.3390/md21010020.

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Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a Codium tomentosum (CT) aqueous extract was employed for the green synthesis of gold nanoparticles (Au@CT). The complete characterization of

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Teles, Amanda Mara, Leticia Prince Pereira Pontes, Sulayne Janayna Araújo Guimarães, et al. "Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model." Marine Drugs 18, no. 11 (2020): 541. http://dx.doi.org/10.3390/md18110541.

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Background: This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods: Ethyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. The solid Ehrlich tumor model was used for antitumor activity. Female Swiss mice were divided into groups (n = 10/group) as follows: The negative control (CTL−), treated with a phosphate buffered solution; the positive control (CTL+), treated with cyclophosphamide (25 mg/kg); extract treatments at doses of 4, 20, and 100 mg

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Alfaro, Ignacio, Margarita Vega, Carmen Romero, and Maritza P. Garrido. "Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer." Pharmaceuticals 16, no. 11 (2023): 1515. http://dx.doi.org/10.3390/ph16111515.

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Ovarian cancer (OC) is one of the most lethal gynecological malignancies. The use of biological compounds such as non-coding RNAs (ncRNAs) is being considered as a therapeutic option to improve or complement current treatments since the deregulation of ncRNAs has been implicated in the pathogenesis and progression of OC. Old drugs with antitumoral properties have also been studied in the context of cancer, although their antitumor mechanisms are not fully clear. For instance, the antidiabetic drug metformin has shown pleiotropic effects in several in vitro models of cancer, including OC. Inter

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Zouari-Kessentini, Raoudha, Najet Srairi-Abid, Amine Bazaa, Mohamed El Ayeb, Jose Luis, and Naziha Marrakchi. "Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/391389.

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Phospholipases type A2(PLA2s) are the most abundant proteins found in Viperidae snake venom. They are quite fascinating from both a biological and structural point of view. Despite similarity in their structures and common catalytic properties, they exhibit a wide spectrum of pharmacological activities. Besides being hydrolases, secreted phospholipases A2(sPLA2) are an important group of toxins, whose action at the molecular level is still a matter of debate. These proteins can display toxic effects by different mechanisms. In addition to neurotoxicity, myotoxicity, hemolytic activity, antibac

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Andon, Fernando Torres, Alba Pensado-López, Clement Anfray, et al. "Abstract 715: Nanomedicines loaded with TLR agonists and inhibitors of immunosuppression to reprogram the tumor microenvironment." Cancer Research 84, no. 6_Supplement (2024): 715. http://dx.doi.org/10.1158/1538-7445.am2024-715.

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Abstract The stroma of solid tumors is populated by myeloid cells, which mostly represent macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell-derived factors, are key drivers of immunosuppression and support tumor growth and spread to distant sites. Increasing evidence demonstrates their ability to hamper cancer patients' response to most treatments currently applied in the clinic, including immunotherapy. Therefore, strategies to counteract negative effects of TAMs are nowadays gaining momentum at preclinical, translational, and clinical levels. Here, we prese

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Liang, Di, Qi Li, Lina Du, and Guifang Dou. "Pharmacological Effects and Clinical Prospects of Cepharanthine." Molecules 27, no. 24 (2022): 8933. http://dx.doi.org/10.3390/molecules27248933.

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Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. In this review, the important physicochemical properties and pharmacological effects of cepharanthine, particularly the antiviral effect, are systematically

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Rubel, Rosalia, Herta Stutz Dalla Santa, Leandro Freire dos Santos, Luiz Claudio Fernandes, Bonald Cavalcante Figueiredo, and Carlos Ricardo Soccol. "Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms." International Journal of Medicinal Mushrooms 20, no. 4 (2018): 393–403. http://dx.doi.org/10.1615/intjmedmushrooms.2018025979.

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Bovi, Michele, Maria E. Carrizo, Stefano Capaldi, et al. "Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms." Glycobiology 21, no. 8 (2011): 1000–1009. http://dx.doi.org/10.1093/glycob/cwr012.

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Maillard, Sébastien, Juliette Gauduchon, Véronique Marsaud, et al. "Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma." Journal of Steroid Biochemistry and Molecular Biology 100, no. 1-3 (2006): 67–78. http://dx.doi.org/10.1016/j.jsbmb.2006.03.008.

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Gimeno, M. Concepción, Helen Goitia, Antonio Laguna, et al. "Conjugates of ferrocene with biological compounds. Coordination to gold complexes and antitumoral properties." Journal of Inorganic Biochemistry 105, no. 11 (2011): 1373–82. http://dx.doi.org/10.1016/j.jinorgbio.2011.07.015.

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Mouhid, Lamia, Marta Gómez de Cedrón, Elena García-Carrascosa, Guillermo Reglero, Tiziana Fornari, and Ana Ramírez de Molina. "Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer." PLOS ONE 14, no. 3 (2019): e0214294. http://dx.doi.org/10.1371/journal.pone.0214294.

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