Gotowe bibliografie tematyczne / CD44 antigen

Spis treści

  1. Artykuły w czasopismach
  2. Rozprawy doktorskie
  3. Książki
  4. Części książek
  5. Streszczenia konferencji
  6. Raporty organizacyjne

Gotowa bibliografia na temat „CD44 antigen”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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Artykuły w czasopismach na temat "CD44 antigen"

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Escribano, Luis, Alberto Orfao, Jesús Villarrubia, et al. "Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples." Analytical Cellular Pathology 16, no. 3 (1998): 151–59. http://dx.doi.org/10.1155/1998/341340.

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The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. Our results show that BMMC from both groups of individuals display a similar but heterogenous immunophenotype. The overall numbers of BMMC are higher in the HM group of individuals (p= 0.08). Three patterns of antigen expression were detected: (1) markers constantly positive in all cases analyzed (CD9, CD29, CD33, CD43, CD44, CD49d, CD49
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Shirure, Venktesh S., Tiantian Liu, Luis F. Delgadillo, et al. "CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions." American Journal of Physiology-Cell Physiology 308, no. 1 (2015): C68—C78. http://dx.doi.org/10.1152/ajpcell.00094.2014.

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Adhesion of circulating tumor cells to vascular endothelium is mediated by specialized molecules that are functional under shear forces exerted by hematogenous flow. Endothelial E-selectin binding to glycoforms of CD44 mediates shear-resistant cell adhesion in numerous physiological and pathological conditions. However, this pathway is poorly understood in breast cancer and is the focus of the present investigation. All breast cancer cell lines used in this study strongly expressed CD44. In particular, BT-20 cells expressed CD44s and multiple CD44v isoforms, whereas MDA-MB-231 cells predominan
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HERMIDA-GÓMEZ, TAMARA, ISAAC FUENTES-BOQUETE, MARIA JOSÉ GIMENO-LONGAS, et al. "Quantification of Cells Expressing Mesenchymal Stem Cell Markers in Healthy and Osteoarthritic Synovial Membranes." Journal of Rheumatology 38, no. 2 (2010): 339–49. http://dx.doi.org/10.3899/jrheum.100614.

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Objective.To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial membranes from human osteoarthritic (OA) and healthy joints.Methods.Synovial membranes from OA and healthy joints were digested with collagenase and the isolated cells were cultured. Synovial membrane-derived cells were phenotypically characterized for differentiation experiments using flow cytometry to detect the expression of mesenchymal markers (CD29, CD44, CD73, CD90, CD105, CD117, CD166, and STRO-1) and hematopoietic markers (CD34 and CD45). Chondrogenesis was assessed by staining for proteoglycans and
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Sallusto, F., and A. Lanzavecchia. "Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha." Journal of Experimental Medicine 179, no. 4 (1994): 1109–18. http://dx.doi.org/10.1084/jem.179.4.1109.

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Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic cells in vivo. These cells have typical dendritic morphology, express high levels of major histocompatibility complex (MHC) class I and class II molecules, CD1, Fc gamma RII, CD40, B7, CD44, and ICAM-1, and lack CD14. Cultured DCs are highly stimulatory in mixed leukocyte reaction (MLR) and are also capable of triggering cord blood naive T cell
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Kansas, GS, MJ Muirhead, and MO Dailey. "Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans." Blood 76, no. 12 (1990): 2483–92. http://dx.doi.org/10.1182/blood.v76.12.2483.2483.

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Abstract We have used three-color flow cytometry to investigate the pattern of expression of the CD11/CD18, CD44, and leukocyte adhesion molecule 1 (LAM-1) adhesion molecules during myeloid and erythroid differentiation in humans. The earliest myeloid cells, identified as CD33loCD15-, were exclusively CD44hi but contained both leukocyte function-associated antigen 1 (LFA-1hi) and LFA-1lo cells, as well as LAM-1+ and LAM-1- cells. This CD33loCD15- myeloid subpopulation expressed only low levels of CD11c and failed to express CD11b, CD14, or any lymphoid (CD3, CD16, CD19) antigens or glycophorin
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Kansas, GS, MJ Muirhead, and MO Dailey. "Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans." Blood 76, no. 12 (1990): 2483–92. http://dx.doi.org/10.1182/blood.v76.12.2483.bloodjournal76122483.

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We have used three-color flow cytometry to investigate the pattern of expression of the CD11/CD18, CD44, and leukocyte adhesion molecule 1 (LAM-1) adhesion molecules during myeloid and erythroid differentiation in humans. The earliest myeloid cells, identified as CD33loCD15-, were exclusively CD44hi but contained both leukocyte function-associated antigen 1 (LFA-1hi) and LFA-1lo cells, as well as LAM-1+ and LAM-1- cells. This CD33loCD15- myeloid subpopulation expressed only low levels of CD11c and failed to express CD11b, CD14, or any lymphoid (CD3, CD16, CD19) antigens or glycophorin. Commitm
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Mancuso, Patrizia, Ines Martin Padura, Giuliana Gregato, et al. "CD45-CD34+ Endothelial Progenitor Cells (EPCs) from Human Adipose Tissue Promote Tumor Growth and Metastases." Blood 118, no. 21 (2011): 2208. http://dx.doi.org/10.1182/blood.v118.21.2208.2208.

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Abstract Abstract 2208 A catalytic role has been proposed in neoplastic angiogenesis and cancer progression for bone marrow-derived endothelial progenitor cells (EPCs). However, in preclinical and clinical studies the quantitative role of marrow-derived EPCs in cancer vascularization was found to be extremely variable. Adipose tissue represents an attractive source of autologous adult stem cells due to its abundance and surgical accessibility. Lipotransfer aspirates (LAs) from patients undergoing breast reconstruction after breast cancer surgery were analyzed by six colors flow cytometry and t
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Parsons, SF, J. Jones, DJ Anstee, et al. "A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a-b- ), Co(a-b-)]." Blood 83, no. 3 (1994): 860–68. http://dx.doi.org/10.1182/blood.v83.3.860.860.

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Abstract We have used a panel of well-characterized monoclonal antibodies (MoAbs) to examine the blood cells of a patient with a novel form of congenital dyserythropoietic anemia (CDA) characterized by intra- erythroblastic and intra-erythrocytic membranous inclusions. Twelve antibodies defining three nonoverlapping epitope groups on the extracellular domain of CD44 all failed to react with the red blood cells (RBCs) of the patient. A rabbit antibody to the cytoplasmic domain of CD44 from normal RBCs failed to react with the patient's RBC ghosts. In contrast, the patient's lymphocytes, granulo
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Parsons, SF, J. Jones, DJ Anstee, et al. "A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a-b- ), Co(a-b-)]." Blood 83, no. 3 (1994): 860–68. http://dx.doi.org/10.1182/blood.v83.3.860.bloodjournal833860.

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We have used a panel of well-characterized monoclonal antibodies (MoAbs) to examine the blood cells of a patient with a novel form of congenital dyserythropoietic anemia (CDA) characterized by intra- erythroblastic and intra-erythrocytic membranous inclusions. Twelve antibodies defining three nonoverlapping epitope groups on the extracellular domain of CD44 all failed to react with the red blood cells (RBCs) of the patient. A rabbit antibody to the cytoplasmic domain of CD44 from normal RBCs failed to react with the patient's RBC ghosts. In contrast, the patient's lymphocytes, granulocytes, an
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Rappa, G., F. Anzanello, and A. Lorico. "CD24 expression and breast cancer stem cell phenotype." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11106. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11106.

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11106 Background: Several studies suggest the existence of breast cancer-initiating cells (BCIC), responsible for tumor development and progression. Initial reports that only the CD44+CD24−/low subpopulation contains BCIC have been challenged by subsequent studies. We examined the relationship between CD24 and biological properties of breast cancer cells. Methods: MA-11 breast carcinoma cells, originating from bone marrow micrometastases, are CD44+ and have an heterogeneous expression of CD24 (214,000/cell; range 0–1,120,000). We have previously reported that upon in vitro culture as mammosphe
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Rozprawy doktorskie na temat "CD44 antigen"

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Varelias, Antiopi. "Studies of CD44 variant isoform expression and function on activated human peripheral blood mononuclear cells and in renal transplantation." Title page, summary and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phv293.pdf.

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Voort, Robbert van der. "Hepatocyte growth factor, Met, and CD44 a ménage à trois in B cells /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/55874.

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Föger, Niko. "Costimulatory function of CD44 : acting in unison with the T cell receptor." kostenfrei, 2000. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-1186.

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Lein, Michael Torsten. "Neue Serummarker bei urologischen Malignomen mit dem Schwerpunkt Prostatakarzinom und Anwendung von Proteinase-Inhibitoren in der Therapie des Prostatakarzinoms." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13730.

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Die vorliegende Habilitationsschrift "Neue Serummarker bei urologischen Malignomen mit dem Schwerpunkt Prostatakarzinom und Anwendung von Proteinase-Inhibitoren in der Therapie des Prostatakarzinoms" faßt Ergebnisse zusammen, die ich in den Jahren von 1996 bis 2000 als Erstautor in wissenschaftlichen Artikeln von peer reviewed Zeitschriften veröffentlicht habe. Zusätzlich werden 14 Arbeiten mit ihren Aussagen eingeschlossen, bei denen ich als Koautor beteiligt war. Gegenstand der Habilitationsschrift sind Untersuchungen zur diagnostischen Optimierung des Tumormarkers Prostataspezifisches Ant
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Bernardi, Maria Auxiliadora. "Expressão de CD44 e CD24 em carcinomas mamários ductais invasivos de acordo com análise dos subtipos moleculares e sua relação com fatores prognósticos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-27102011-172419/.

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Carcinomas de mama são heterogêneos e consistem de diversos tipos celulares. Perfis de expressão gênica usando DNA microarrays identificaram quatro subtipos moleculares fundamentais baseados na expressão de receptores hormonais (estrógeno e progesterona) e de fator de crescimento epidérmico (HER2) (luminal tipo A, luminal tipo B, tumores expressando somente HER2 e triplos negativos) refletindo a heterogeneidade molecular dos carcinomas. Sugeriu-se que esta heterogeneidade advém da presença de células tronco tumorais com a capacidade de se diferenciar ao longo de vias divergentes e outros estud
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Haas, Karen Marie. "Induction and regulation of bovine B lymphocyte responses /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999290.

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Giordanengo, Valérie. "Glycoproteines lymphocytaires, infection vih et autoimmunite." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX20652.

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Schmitz, Paul. "Mechanismen immunologischer Toleranz nach Lebertransplantation : Untersuchungen zum Zytokinmuster intrahepatischer CD4+ CD45RCpos und CD4+ CD45RCneg T-Lymphozyten." Doctoral thesis, kostenfrei, 2007. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-26703.

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Saeland, Sem. "Caractérisation et physiologie in vitro des cellules hématopoïétiques humaines exprimant l'antigène CD34." Lyon 1, 1992. http://www.theses.fr/1992LYO1H053.

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Rose, Charlotte S. P. "CD4 antigen chimaeras of poliovirus." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240217.

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Książki na temat "CD44 antigen"

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Scheunemann, Peter. Inzidenz und prognostische Bedeutung der Expression von Intercellular Adhesion Molecule-1 (ICAM-1, Human Leucocyte Antigen (HLA) Class I, Adhäsionsmolekül CD44 und Tumorsuppressorprotein p53 bei Lebermetastasen kolorektaler Karzinome und kolorektaler Primärtumoren: Inzidenz der Expression des Oberflächenmoleküls 17-1A bei Lebermetastasen und Lebermetastasenrezidiven. [s.n.], 1997.

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S, Jack Robert, ed. CD14 in the inflammatory response. Karger, 2000.

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D, Stern Robert M., ed. Hyaluronan in cancer biology. Academic Press, 2009.

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Rahelu, Manjit. Characterisation of human CD4[superior plus] cytolytic T lymphocytes, with special reference to mycobacterial antigens. University of Birmingham, 1992.

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Kuhrober, Andreas. Klonierung und heterologe Expression von humanen Oberflächenantigenen am Beispiel des Interferon-[beta]-Rezeptors [Interferon-beta-Rezeptors] und des CD43-Antigens. [s.n.], 1991.

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Workshop on Mechanisms and Specificity of HIV Entry into Host Cells (1989 San Francisco, Calif.). Mechanisms and specificity of HIV entry into host cells. Plenum Press, 1991.

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Giessen, Justus Liebig-Universität, ed. Screening einer rekombinanten Proteinbank mit CD4⁺-T-Zellen vaccinierter Mäuse zur Identifizierung von T-Zell-Antigenen des Parasiten Schistosoma mansoni. Tectum-Verl., 1998.

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Girgrah, Nigel. Characterization of surface antigen CD44 on astrocytes in normal and diseased brain. 1993.

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Chuck, Roy S. H. Characterization of a multi-receptor complex on the T cell surface: Association of CD4 with the T cell antigen receptor. 1993.

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Ryu, Seong-Eon. Crystallographic studies on HIV-binding fragments of human CD4. 1991.

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Części książek na temat "CD44 antigen"

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Osada, Atsushi, Atsushi Saitoh, Nami Yasaka, Masutaka Furue, and Kunihiko Tamaki. "Expression of CD44 Antigen by Langerhans Cells and Thy1+ Dendritic Epidermal Cells - Ontogenetic Variation and Its Role in Migration." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1971-3_25.

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Canaday, David H. "Production of CD4+ and CD8+ T Cell Hybridomas." In Antigen Processing. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-218-6_22.

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Canaday, David H. "Erratum: Production of CD4+ and CD8+ T Cell Hybridomas." In Antigen Processing. Humana Press, 2017. http://dx.doi.org/10.1007/978-1-62703-218-6_43.

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Matthis, Jessica, and Helena Reijonen. "Production of Primary Human CD4+ T Cell Lines and Clones." In Antigen Processing. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-218-6_40.

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Matthis, Jessica, Victoria King, and Helena Reijonen. "Production of Antigen-Specific Human CD4+ T Cell Lines and Clones." In Antigen Processing. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9450-2_27.

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Kong, Ying Ying, and William W. Kwok. "Identification of Human Antigen-Specific CD4+ T-Cells with Peptide–MHC Multimer Technologies." In Antigen Processing. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9450-2_26.

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Weiss, R. A., P. R. Clapham, and J. A. McKeating. "The Role of CD4 Antigen in HIV Infection." In Progress in Immunology. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83755-5_137.

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Janeway, Charles A., Pilar Portoles, John P. Tite, Jose Rojo, Kaj Saizawa, and Barry Jones. "Recognition of MHC Class II Antigens by the CD4: T Cell Receptor Complex." In H-2 Antigens. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-0764-9_44.

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Banchereau, J., B. Dubois, J. Fayette, et al. "Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1971-3_16.

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Mazerolles, Fabienne, F. Amblard, O. Lecomte, et al. "Regulation of Antigen-Independent Adhesion of CD4 T Cells." In Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9266-8_18.

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Streszczenia konferencji na temat "CD44 antigen"

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Liu, Han, Yunnan Liu, Qihang Gao, Ren Xu, Xiao Xiao, and Chunying Pang. "Stability Study of Leukocyte Differentiation Antigen CD34 (Flow Cytometry-PE) Detection Kit." In 2024 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). IEEE, 2024. https://doi.org/10.1109/3m-nano61605.2024.10769611.

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Sheng, Anqi, Qingshuang Wang, Hao Zhang, Ren Xu, and Xiao Xiao. "Performance Verification for Leukocyte Differentiation Antigen CD34 Assay Kit by Flow Cytometry." In 2024 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). IEEE, 2024. https://doi.org/10.1109/3m-nano61605.2024.10769627.

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Hachenberg, J., R. Klapdor, S. Wang, et al. "971 NK cell-mediated eradication of ovarian cancer cells with a novel chimeric antigen receptor directed against CD44." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.497.

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Wernet, P., E. M. Scheider, P. Sarin, et al. "Demonstration of HIV-encoded Proteins in Cultured and in Uncultured CD 4 Positive Mononuclear Cells from Hemophilia Patients Employing Monoclonal Antibodies against p 15, p 24, GP 41, GP 120, and Reverse Transcriptase." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644683.

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In the light of the large percentage of hemophilia patients with antibodies to HIV the identification of a specific virus infection in comparison to HIV antibody negative hemophilia patients has reached crucial importance. The low success rates of direct virus culture techniques together with the as yet low AIDS-di-sease rate observed in these patients separate these patients from the other main risk groups. Within this context, we studied the expression of CD3, CD4, CD8, and HLA class II antigens on fixed cells after PHA stimulation and Interleukin 2 propagation as well as on untreated blood
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Chieh Chen, Yu, Li Yun Wang, Chi Chih Chen, et al. "CD154 ELEVATING CELLULAR IMMUNITY BY UP-REGULATING THE PERCENTAGES OF ANTIGEN-SPECIFIC POSITIVE INTERFERON-GAMMA EXPRESSING CELLS." In Singapore International Conference on Research in Life-Science & Healthcare, 04-05 March 2025. Global Research & Development Services Publishing, 2025. https://doi.org/10.20319/icrlsh.2025.12.

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CD154 plays a central role in the development and regulation of adaptive immune responses in mammals and thus may act as a potential molecular adjuvant due to its enhancement of cytokine expression in immune cells. In this study, CD154-coding sequence was linked with the E2 antigen sequence of the Classical swine fever virus (CSFV) to produce an E2-CD154 vaccine and the specific pathogen free piglets at the age of 4-week old was used as an animal model. The CpG adjuvant, a Toll-like receptor 9 agonist, was used as a positive control. The animals were randomized into three groups and primarily
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Bhattacharya, Avik, Molly C. Lyons, Samuel J. Landry, and Ramgopal R. Mettu. "Incorporating antigen processing into CD4+ T cell epitope prediction with integer linear programming." In BCB '22: 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. ACM, 2022. http://dx.doi.org/10.1145/3535508.3545545.

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Foster, Aaron, Joanne Shaw, Matthew Collinson-Pautz, et al. "Abstract 898: Single-cell multiplex proteomics reveals synergistic activity of antigen and MyD88/CD40 stimulatory signals on promoting polyfunctional chimeric antigen receptor T cells." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-898.

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Thelen, M., M. Garcia-Marquez, J. Lehmann, et al. "P06.05 Endogenous T-cell responses to ten major cancer testis antigens are frequent in esophago-gastric adenocarcinoma and antigen-specific T cells can be expanded using CD40-activated B cells." In iTOC8 – the 8th Leading International Cancer Immunotherapy Conference in Europe, 8–9 October 2021, Virtual Conference. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/jitc-2021-itoc8.39.

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Razawy, W., N. Salioska, P. Asmawidjaja, et al. "THU0032 Ccr6+cd4+ t cells drive antigen-induced arthritis via the il-23r pathway." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6385.

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Haque, Azizul, Duncan Norton, Bently Doonan, and Shereen Amria. "Abstract 4787: GILT regulates antigen processing and CD4+ T cell recognition of melanoma cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4787.

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Raporty organizacyjne na temat "CD44 antigen"

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Perelson, Alan S., and Robertus de Boer. Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1058057.

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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused
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แก้วกิติณรงค์, กมล, та นิพนธ์ อุดมสันติสุข. บทบาทของ MAIT cells ในการควบคุมการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2016. https://doi.org/10.58837/chula.res.2016.28.

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วัณโรค (Tuberculosis) เป็นสาเหตุหลักของการเสียชีวิตจากโรคติดเชื้อของประชากรทั่วโลก (1) วัณโรคเกิดจากการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis ภูมิต้านทานของร่างกายที่มีต่อเชื้อ Mycobacterium tuberculosis ประกอบด้วยเซลล์จากส่วนของ innate immunity และ adaptive immunity ในส่วนของ adaptive immunity กลุ่มของ T cells ที่มีส่วนสำคัญ ได้แก่ ทั้ง conventional T cells (ทั้ง CD8+ และ CD4+) และ non-conventional T cells (MAIT, NKT, CD1-restricted T cells) (2) MAIT (Mucosal-associated invariant T) cells จัดอยู่ในกลุ่มของ non-conventional T cells ที่พบได้ปริมาณมากตามเยื่อบุของร่างกาย รวมถึงปอด (3) นอกจ
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Baszler, Timothy, Igor Savitsky, Christopher Davies, Lauren Staska, and Varda Shkap. Identification of bovine Neospora caninum cytotoxic T-lymphocyte epitopes for development of peptide-based vaccine. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695592.bard.

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The goal of the one-year feasibility study was to identify specific cytotoxic T-lymphocyte (CTL) epitopes to Neosporacaninum in the natural bovine host in order to make progress toward developing an effective peptide-based vaccine against bovine neosporosis. We tested the hypothesis that: N. caninum SRS2 peptides contain immunogenicCTLepitope clusters cross-presented by multiple bovine MHC-I and MHC-IIhaplotypes. The specific objectives were: (1) Map bovine CTLepitopes of N. caninum NcSRS-2 and identify consensus MHC-I and class-II binding motifs; and (2) Determine if subunit immunization with
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