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Rozprawy doktorskie na temat „Challenges”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Porter, Noah. "Real challenges, virtual challengers : the Democracy for America movement." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002078.

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Sørheim, Ingrid By. "Kosovo's present challenges." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sosiologi og statsvitenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25728.

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Kosovo is struggling in its attempt to develop into a liberal democratic state, and on its path toward EU membership. The rule of law has not yet been consolidated. Corruption is connected to the lack of economic growth, and is hindering domestic progress. The political system is made up by hierarchal, close- knit structures of power, and lacks clear ideological basis. This is hindering a real democratic process from taking place, along with the lack of transparency and accountability.

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Meneses, Flávio Silva. "Future network challenges." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/18672.

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Engenharia Eletrónica e Telecomunicações<br>As capacidades de conetividade dos equipamentos móveis têm obrigado a constante mudança do modo de operação da rede, exigindo cada vez mais recursos. Visando as futuras redes 5G, existe a necessidade de evoluir as presentes redes móveis, melhorando as suas arquiteturas e mecanismos. Estas futuras redes, vistas como a próxima geração arquitetural das telecomunicações, tenta suportar a "explosão" do número de equipamentos ligados, serviços e tecnologias de acesso, apoiando-se fortemente nas redes definidas por software (do inglês, Software Defin

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4

Keane, Philomena Helen Aine. "Storying challenges in communities." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1481.

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The methodology of the thesis guided the research focus. It endeavoured to use a community psychology approach, collaboratively working with Mothers Against Violence (MAV) - a volunteer group based in Moss Side, Manchester. The research question evolved through attendance at MAV meetings, where members expressed concern with how they felt their community was being perceived. Members believed that negative stereotypes had impacted on investment, employment, public services, and opportunities for young people. Five members of MAV were interviewed using semi-structured re-authoring questions from

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VIEIRA, MARTHA ALKIMIN DE ARAUJO. "(LITERARY) FICTIONS: CONTEMPORARY CHALLENGES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5886@1.

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UNIVERSIDADE ESTACIO DE SÁ<br>O estudo das ficções (literárias), no marco dos sistemas midiÃ¡ticos e da mediação digital e suas conexões com o processo de produção e sistematização do conhecimento, em modelos de realidade aponta a presença da ficcionalidade como fenômeno constitutivo de todos os segmentos da vida social e não apenas com o objeto sob jurisdição exclusiva da literatura. O estatuto das ficções literárias em interseção com a proliferação de ficções não literárias e a virulênncia das transformações tecno-científicas, das práticas sociais, estatisticas e culturais tensionam

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6

Moodley, Kavilan. "Challenges for cosmological concordance." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620433.

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Choli, Hatice. "Digital inclusion : the challenges." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/6363/.

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This research investigated attitudes and behaviours of socially excluded individuals as they engage with further learning through digital technologies in individually orientated and free informal learning settings. The study specifically explored the impact of socio-personal attitudinal and behavioural factors that may impede participation. The research was concentrated in a South East London borough and based within a successful joint initiative between a local authority and third sector organisations. This unique partnership, of over 25 centres, provided access to the hardest to reach groups

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Costa, Joana Seara da. "Galp Energia: huge challenges." Master's thesis, NSBE - UNL, 2010. http://hdl.handle.net/10362/10336.

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Shifrel, Zachary D. "Challenges to Effective Realism." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/102340.

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That a theory is merely effective has historically counted against it, especially in pro-realism discourse. For example, many realists take the interpretation of a theory to amount to specifying what the world would be like was the theory true (or characterizing the possible worlds picked out by the theory). But effective theories are not true simpliciter. They describe a limited subset of nature and only approximately so, giving the traditional realist little to work with. The effective realist gives up on the traditional realist project, noting that contemporary physical theories tell us not

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10

Holt, Jim. "Behavioral Challenges in Dementia." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/6469.

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Hoominfar, Elham. "Challenges of Monolingual Education." Bowling Green State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1404055112.

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Feltmate, Roland H. "Worship challenges in Canada." Theological Research Exchange Network (TREN), 1995. http://www.tren.com.

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13

Pezzotta, Elisa. "Adaptations : Stanley Kubrick's challenges." Thesis, University of Roehampton, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515227.

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Gaude, Linn Linn. "Megacity Challenges: Safe Food and Education– : an exploration of challenges and possible ICT solutions." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-150415.

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In 2012, 50 % of the world’s citizens lived in urban areas. By the year of 2050 that number is estimated to have increased to 70 % with the biggest growth of cities seen in Asia and Africa. Megacities, urban areas with an excess of 10 million inhabitants, are increasing in number and will bring new challenges as well as opportunities. One of humans’ basics needs of survival is food. Today more and more food scandals about dangerous additives or chemicals, fake food, and untruthful listing of ingredients are surfacing in the media. At the same time knowledge about food and where it comes from i

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Waygood, Richard. "Challenges in Intercultural Business Communication." St. Gallen, 2005. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02603207001/$FILE/02603207001.pdf.

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Lagerman, Moa, and Mikael Pietilä. "Middle Managers : Facing Everyday Challenges." Thesis, Jönköping University, JIBS, Business Administration, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-140.

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<p>Many industries have gone through changes in the last decades, everyone involved have been affected but few have encountered the same amount of changes as the middle managers. Being in the centre of the organisation, torn between wills, middle managers have struggled during the last years to redefine their job. There exists research describing their workdays, what they do and how they spend their time, but we have not found any study that has tried to investigate what challenges the middle managers face.</p><p>The purpose of this study is to identify the challenges faced by internally-promo

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17

Michalski, Annette. "Overcoming challenges of shotgun proteomics." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-151295.

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Suwala, Pawel. "Challenges with modern web testing." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118268.

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The number of web applications continues to grow rapidly. Many applications that were traditionally desktop-based such as word processors, email clients or even file managers have now their web alternatives that often have bigger user base. While the software world is shifting from providing desktop-based applications to offering cloud-based services, challenges arise to provide high quality software in this radically different environment. Web-based applications are different in many aspects to their desktop equivalents. Web-based and desktop-based applications have radically dissimilar archi

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19

Chipman, Russell A. "Challenges in coronagraph optical design." SPIE-INT SOC OPTICAL ENGINEERING, 2017. http://hdl.handle.net/10150/627190.

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The point spread function (PSF) for astronomical telescopes and instruments depends not only on geometric aberrations and scalar wave diffraction, but also on the apodization and wavefront errors introduced by coatings on reflecting and transmitting surfaces within the optical system. Geometrical ray tracing provides incomplete image simulations for exoplanet coronagraphs with the goal of resolving planets with a brightness less than 10<^>-9 of their star located within 3 Airy disk radii. The Polaris-M polarization analysis program calculates uncorrected coating polarization aberrations couple

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20

Imedashvili, Sopiko, Ani Kekua, and Polina Ivchenko. "Rural Entrepreneurship: Challenges and Opportunities." Thesis, Högskolan i Jönköping, Internationella Handelshögskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-21482.

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According to World Bank Report published in 2012, the rural population in Sweden is 15.3 %. Rural population is calculated as difference between total populations minus urban population. 15.3 % clearly shows how important rural areas are for Sweden’s future development. Entrepreneurship plays the integral role in rural area development. However, earlier research has shown only economic perspective of rural development. On the other hand, the new ways to discover the challenges and opportunities for entrepreneurs in small firms were needed.

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21

Dong, Chuoyan Maggie, and 董婥嫣. "Current challenges in channel relationships." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40687521.

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Chan, Kiu-yan Calvin, and 陳翹昕. "Challenges to arterial endothelial function." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46916581.

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Tang, Yin-hang Phoebe, and 鄧彥姮. "Selling Skylab : dreams and challenges." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198821.

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This thesis investigates the history of Skylab from political, social, and public relations perspectives. It focuses on the reasons to build Skylab, the difficulties Skylab met and most importantly how NASA overcame these difficulties by selling Skylab actively. The thesis argues that in order to maximize popular support and interest in Skylab to secure funding, NASA improved its public relations and sold Skylab according to public expectations. The first chapter explores how and why NASA selected Skylab as the program to succeed Apollo. Politically, NASA built Skylab for national prestige and

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Thompson, Laura Jean. "U.S. maritime security sustainability challenges." Thesis, Monterey, California. Naval Postgraduate School, 2011. http://hdl.handle.net/10945/5539.

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CHDS State/Local<br>Approved for public release; distribution is unlimited<br>The U.S. maritime domain includes vast resources and enables transportation of goods and services across the globe. Similar to all critical infrastructures and key resources, the maritime domain can be exploited to cause harm to people and disrupt economic stability. The President's National Strategy for Maritime Security and the U.S. maritime security framework is designed to deter, prevent and respond to a broad range of threats and exploitations. The U.S. maritime security system has evolved over the past deca

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Tagert, Adam C. "Cybersecurity Challenges in Developing Nations." Research Showcase @ CMU, 2010. http://repository.cmu.edu/dissertations/22.

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This thesis examines the guidance that is being given to developing nations that are rapidly deploying information and communication technologies. It studied the African countries of Rwanda and Tunisia to draw lessons of the situation and potential methods of improving the situation. The thesis found that developing nations are often recommended to implement a conglomeration of existing rules and regulations found in other countries especially in European countries and in the United States. Developing countries are also recommended to create national CERTs, organizations of cybersecurity exper

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Kovach, Jeremy J. "Operational challenges of strategy execution." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/52273.

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Operations management studies the process of transforming material, labor, energy, or ideas into goods or services. Operations strategy outlines how firms leverage their capabilities to achieve competitive advantage. While developing or possessing these capabilities is paramount, they must be successfully leveraged to yield competitive advantage. This thesis comprises three essays which consider how firms can successfully implement their operations strategy, specifically within the context of supply chain management, remanufacturing, and project execution. The first essay (Chapter 2) empir

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Rodríguez, Morales Alfonso J., and Percy Mayta-Tristan. "Challenges for Colombian medical journals." The Lancet, 2014. http://hdl.handle.net/10757/333625.

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Javu, Mirranda Thobela. "Translating diabetes brochures: Challenges encountered." University of Western Cape, 2017. http://hdl.handle.net/11394/6545.

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Masters of Art<br>The aim of this study was to develop isiXhosa terminology for diabetes brochures written in English or in medical terms, to enable diabetes patients to access information on their disease. Lefevere (1992a: xi) describes translation as “rewriting of an original text”. This study re-evaluated Lefevere's concept of translation by examining English brochures and translating them into isiXhosa brochures. In order to demonstrate how the translator of the English brochures transported the source text messages to the target language, literature was reviewed. Translation theories or

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Nagpure, Prashant. "Homebased healthcare : issues and challenges." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45232.

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Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2008.<br>Includes bibliographical references (leaves 75-80).<br>Healthcare costs in United States are projected to rise to 20% of GDP by 2015. This is a cause of major concern and current political debate. The largest contributor to this cost is the hospital cost accounting for 30 % to the healthcare expenditure. Segmenting healthcare through new delivery mechanisms may be an answer to the rising cost. Disruptive innovations like Retail clinic's is a prime example of this segmentation providing

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Kamath, Gautam (Gautam Chetan). "Modern challenges in distribution testing." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120373.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 321-356).<br>Hypothesis testing is one of the most classical problems in statistics. While it has enjoyed over a century of intense study, only recent focus has been on the small-sample regime, with interest in sample complex

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Gad, Usama. "The digital challenges and chances." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201593.

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In this paper, I would like to explore the new ways of perceiving Papyri und Papyrology i.e. papyrological studies from Egyptian-Arabic perspectives. The paper will shed light on three main and, from my point of view, intertwined ways of thinking about this discipline that has been newly of importance just because of the new media. First, one should consider the question of legal status of papyri presented online, including their provenance, and the Egyptian (legal) point of view in this regard. Most, if not all, the available, papyri databases, which presents papyri online, suffice themselves

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Chapin, John, and Alok Shah. "SOFTWARE RADIO TECHNOLOGY AND CHALLENGES." International Foundation for Telemetering, 2002. http://hdl.handle.net/10150/607499.

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International Telemetering Conference Proceedings / October 21, 2002 / Town & Country Hotel and Conference Center, San Diego, California<br>This paper provides an overview of software radio and its current state in the industry. Software radio is a technology in which all of the waveform processing, including the physical layer, of a wireless device moves into software. If designed properly, this approach leads to dramatically improved device flexibility, software portability, and reduced development costs. Of course, such a technology brings with it numerous challenges, from hardware componen

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Roza, Mafalda Correia Larroudé Trigo da. "Mozambikes – The challenges of growth." Master's thesis, NSBE - UNL, 2013. http://hdl.handle.net/10362/11610.

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A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics<br>Mozambikes is a Mozambican social enterprise founded in 2009, whose mission is to “transform the lives of rural Mozambicans by providing higher quality bicycles at low market prices throughout the country.”1 The idea of Mozambikes resulted from a roadtrip, in which Lauren and Rui came across many rural Mozambicans walking and carrying heavy burdens on foot. They realized that bicycles would provide a quicker and safer way to reach the cit

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Tran, David. "Multicultural project settings : Perceived challenges." Thesis, Karlstads universitet, Handelshögskolan (from 2013), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-84580.

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The number of culturally diverse project teams has increased significantly over the years, as internationalization within organizations become more common. Individuals are more interconnected than ever, due to increased cultural exchange. The increased globalization also has created many challenges, such as streamlining multinational organizations, management and communication in multicultural settings. Furthermore, there has been studies showing that culturally diverse project teams have both a positive and negative impact on projects. The purpose of this study is to contribute to a deeper un

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Van, Heerden Elmarie. "Data challenges in pulsar searches." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:98b329d6-4dbf-4956-9277-4b52fa2971bd.

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Technological advances coupled with a decline in digital storage costs have resulted in a profusion of data being created, collected and consumed. These data give rise to new challenges and opportunities in many disciplines ranging from science and engineering to biology and finance. An example of a future project in radio astronomy that promises both Big Data and Big Discoveries is the Square Kilometre Array (SKA) radio telescope project. Astrophysicists are confident that the Big Data amassed by the SKA will not only answer fundamental questions regarding the Universe but also contain big di

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Rodriguez, Perez Jesus Alberto. "Microblog retrieval challenges and opportunities." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8666/.

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In recent years microblogging services have changed the way we communicate. Microblogs are a reduced version of web-blogs which are characterised by being just a few characters long. In the case of Twitter, messages known as \textit{tweets} are only 140 characters long, and are broadcasted from followees to followers organised as a social network. Microblogs such as tweets, are used to communicate up to the second information about any topic. Traffic updates, natural disaster reports, self-promotion, or product marketing are only a small portion of the type of information we can find across mi

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Karlsson, Lisa Caroline, and Iris Sørgård. "Distribution Challenges within Grocery Retailing." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Centre of Logistics and Supply Chain Management (CeLS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39930.

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Grocery retailing can be recognized as a market with high competitive pressures which requires a focus on the customers and operational efficiencies to stay competitive. Distribution centers play a vital role in grocery retailing since they constitute a significant part of the total cost of logistics. To reach an overall profitability in a company, an effective and efficient distribution is needed. Grocery retailing and distribution challenges has been discussed previously in literature for compact countries whereas a limited focus has been on elongated countries. The purpose of this thesis is

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Mansberger, Paul, and Filip Projic. "Survival Challenges of Environmental Entrepreneurs." Thesis, Högskolan i Jönköping, Internationella Handelshögskolan, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39687.

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Environmental entrepreneurs are considered to be important drivers for an environmentally sustainable development. As other entrepreneurs, they face survival challenges while operating their businesses. Due to the increased importance of environmental entrepreneurs in counteracting environmental issues we argue that it is necessary to gain an understanding of their specific challenges of survival. In this thesis, we build theory based on environmental venture cases located in Sweden. We provide an extensive overview of the current literature and contribute by identifying an institutional dimen

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Coloma, Manrique Carmen Rosa. "New challenges for university teaching." En Blanco y Negro, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/117006.

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The article points how the knowledge society provides an opportunity to review the orientation and strategy of teaching methods in academia. It puts forward that "it is not only a matter of being leaders in the generation of new knowledge, scientific and technological production, transference of knowledge and innovation", but also that we need university to be the "critical consciousness of society, a hub for reflection, analysis and prospective about the evolution of society itself". Thus, it meditates on the goal of university and argues that it must focus its ability to transform the learni

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Russ, Ricardo. "SCALING CHALLENGES IN DIGITAL VENTURES." Thesis, Umeå universitet, Institutionen för informatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150563.

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The number of startups is on the rise, specifically digital startups with products entirely based on software. These companies are facing a resilient challenge when it comes to increasing their user base, revenue or market share. This process is called scaling, which is an essential part for every startup in order to establish themselves in the market. While there are several generic models focusing on scaling a business, there seems to be a lack of scientific research focusing on the challenges during the process of scaling. This paper describes a qualitative study focusing on purely digital

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Alam, Faysal, and Mansoor Ul Hasan Butt. "Motives and Challenges of Offshoring." Thesis, Högskolan i Gävle, Avdelningen för ekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-27835.

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Abstract Aim: The aim of this study is to explore offshoring in terms of different motives, challenges, advantages and disadvantages a company face. Method: Qualitative research method is adopted to conduct the study. The data was collected from interview questions from 11 personnel of M&F Associates with relative offshoring experience. Theories from peer-reviewed journal articles and relevant books were consulted throughout the study. Results and Conclusion: The findings suggest that major motives and advantages of offshoring strategy are cost efficiency. Contingency plan and develo

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Brehm, S. Seitz. "Navigating Challenges, Lessons Learned: ASCENT." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/8367.

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Getman, Victoria. "Global challenges in higher education." Thesis, Київський національний університет технологій та дизайну, 2020. https://er.knutd.edu.ua/handle/123456789/16637.

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Дерев`янко, Юрій Миколайович, Юрий Николаевич Деревьянко, Yurii Mykolaiovych Derevianko, and П. Філіпс. "Challenges Facing Entrepreneurship in Ghana." Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/50259.

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Below are some of the most common challenges that entrepreneurs face or are likely to encounter in Ghana: Human resources. Many of the entrepreneurs spoken to complain of problems with finding the human resources for their business and those that run such businesses may not possess the requisite skills to manage their enterprises.

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Kisera, Tetyana, and Тетяна Олегівна Кісера. "COVID vaccine: supply chain challenges." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50508.

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1. Mia Rabson (2021). From science to syringe: COVID-19 vaccines are miracles of science and supply chains. CTV News (Bell Media). (Date of appeal: 20.03.2021) [Electronic resource]. - Access mode:https://www.ctvnews.ca/health/coronavirus/from-science-to-syringe-covid-19-vaccines-are-miracles-of-science-and-supply-chains-1.5327003 2. Reporting by Michael Shields; editing by Jason Neely (2021). Lonza gets Swiss OK to start Moderna vaccine production –paper. Reuters. (Date of appeal: 20.03.2021) [Electronic resource]. - Access mode:https://www.reuters.com/article/health-coronavirus-swiss/lonza

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Shevchenko. "CHALLENGES FOR EDUCATION IN FUTURE." Thesis, Київ 2018, 2018. http://er.nau.edu.ua/handle/NAU/33902.

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Bengtsson, Anna-Karin. "CONSTANTLY NEW CHALLENGES FOR NURSES." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-26003.

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ABSTRACT Introduction: The number of patients treated in inadequate hospital wards is increasing. Elderly and fragile patients with medical conditions are particularly vulnerable for being placed in inadequate hospital wards. They also run a twice as high risk of health-related complications and increased mortality. RNs obtain specific knowledge by working on specific wards. However, RNs’ experience of caring for outliers seems relatively unexplored, as few studies explore RNs’ experiences in giving nursing care to outliers. Aim: The aim of the study was to explore RNs’ experience of giving ca

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Madaeni, Seyed Hossein. "Challenges in Renewable Energy Integration." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1342628585.

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Andersson, Sabina. "Simulation challenges in robotic grasping." Thesis, Umeå universitet, Institutionen för fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186487.

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Grasping and dexterous manipulation is a huge area in the current robotic research field. Traditionally in industrial environments, robots are customized for a certain task and work well with repetitive movements where the entire process is predetermined and deterministic. The possibility for a robot to adapt to its surroundings and manipulate objects with unknown properties is very limited and requires new models and methods. It is advantageous to explore and test new algorithms and models in a simulated environment before building physical systems. This thesis focuses on making the developme

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Aul, Raminder Singh. "Bronchial challenges in airways disease." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html.

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Background: Airways diseases comprise mainly of COPD and asthma. There is a need to develop both new models and improve methodologies of existing models these diseases. LPS challenges in smokers would be an excellent model to study the drugs directed against TLR4 mediated inflammation in COPD. In asthma allergen challenges are established models of disease and extensively used in clinical trials. Back to back reproducibility of two bolus dose allergen challenges has not been studied; this would provide intra subject standard deviations which are useful for accurate power calculations for bolus

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