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Rozprawy doktorskie na temat „Cholesterol Physiological effect”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Volk, Catherine B. "Role of inhibition of protein prenylation in the cholesterol-dependent and cholesterol-independent effects of simvastatin." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339597.

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Statins are widely used to treat hypercholesterolemia. Statins inhibit cholesterol biosynthesis, thereby activating genes involved in cholesterol homeostasis, which are under the control of the Sterol Regulatory Element (SRE). Statins also have cholesterol-independent beneficial cardiovascular effects mediated through the phosphoinositide 3-kinase (PI3-K) / Akt signaling pathway and by inhibition of protein prenylation. Because statins inhibit the synthesis of isoprenoids, they can act by inhibiting the small signaling GTPases Ras and Rho, which require post-translational prenylation to become

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Jain, Deepak M. "Effect of corn fibre oil and its constituents on cholesterol metabolism and intestinal sterol transporter gene expression in hamsters." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98732.

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The cholesterol-lowering effect of corn fiber oil, obtained from the seed coats of corn kernels, has been reported previously. Corn fiber oil contains phytosteryl fatty acyl esters, ferulate phytostanyl esters, and free phytosterols. To date, however, no studies have examined the cholesterol-lowering efficacy of ferulate phytostanyl esters. Moreover, although plant stanols and sterols have been established as cholesterol-lowering agents over the past five decades, their exact mechanisms of action are not clearly understood. One of the possible mechanism is that plant sterols/stanols disrupts t

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Barake, Roula. "Effects of plant sterols and glucomannan on parameters of cholesterol kinetics in hyperlipidemic individuals with and without type 2 diabetes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83964.

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The objective of this study was to examine the effects of plant sterols and/or glucomannan on lipid profiles and cholesterol kinetics in hyperlipidemic individuals with or without type 2 diabetes. It was hypothesized that plant sterols and glucomannan reduce circulating cholesterol levels and may have an additive or synergistic effect when combined by reducing cholesterol absorption. Thirteen type 2 diabetics and sixteen non-diabetics all mildly hypercholesterolemic free living subjects participated in a randomized crossover trial consisting of 4 phases, 21 days each. Subjects consumed

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Vanstone, Catherine A. "Influence of phytosterols versus phytostanols on plasma lipid levels and cholesterol metabolism in hypercholesterolemic humans." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33854.

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The objective of this research was to examine the effects of sitosterol and sitostanol supplementation on plasma cholesterol levels and cholesterol metabolism in hypercholesterolemic subjects consuming a fixed foods diet in a four-phase crossover design. It was hypothesized that addition of either phytosterols, phytostenols, or a 50:50 mixture of sterols and stanols to butter would reduce circulating cholesterol levels, despite butter's hypercholesterolemic effect, through actions involving cholesterol absorption, synthesis, and turnover rates. The data obtained indicate that in their free, un

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Varady, Kristina A. "Effect of plant sterol supplementation and endurance training on cardiovascular disease risk parameters and cholesterol kinetics in previously sedentary hypercholesterolemic adults." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111831.

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Background. A high ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, in addition to increased levels of small low-density lipoprotein (LDL) particles, are important indicators of cardiovascular disease risk. Therefore, interventions that combine the lowering of total cholesterol and raising of HDL cholesterol concentrations that also increase LDL particle size, may be preventive against cardiovascular disease. Plant sterols decrease total cholesterol and LDL cholesterol levels by 10-15%, while exercise increases HDL cholesterol levels by 4-22%. In view of their compleme

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Journoud, Mélanie. "The effect of plant sterols on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with type 2 diabetes compared with non-diabetic controls /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80296.

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The objective of this study was to compare the effect of phytosterols (PS) on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with or without type 2 diabetes. It was hypothesised that the response to PS would differ between both groups due to different lipid metabolism. During this randomised, double blind, crossover trial, participants consumed a controlled diet with placebo or PS for 21 days.<br>Plasma total cholesterol (TC) decreased with placebo and PS (10.9% and 9.7% in non-diabetic versus 11.6% and 13.6% in diabetic participants, p < 0.05). Plasma low-d

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Anema, Richard Flagg. "A single case study of the acute effects of strenuous exercise on blood lipids." Scholarly Commons, 1991. https://scholarlycommons.pacific.edu/uop_etds/2210.

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The purpose of the present study was to determine the acute effects of strenuous exercise on the following blood constituents: total cholesterol (TC) 1 triglycerides (TG) 1 high density lipoproteins (HDL-C) 1 and low density lipoproteins (LDL-C). A single case study was performed during a 20 day testing period. Two century bicycle rides ( 100 miles) were used as the strenuous exercise bouts. Blood samples were drawn each day and immediately after each 100 mile ride. A pre-set exercise and diet regimen were followed every day of the 20 day procedure. A t-test upon TC 1 TG 1 HDL-C 1 and LDL-C wa

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Bone, Emily C. "A determination of the effects of nutrition and physical activity education on cholesterol levels over time in the worksite." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1246465.

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The purpose of this study was to determine the effectiveness of group nutrition and physical activity education classes in lowering cholesterol levels of worksite employees at 6-and 12-month intervals. A total of 32 participants were followed through the study. The group of participants included 24 female and 8 males, all over the age of 40. The data were analyzed using one-way ANOV A with repeated n1easures, post¬hoc analysis, Pearson's correlation coefficient, and ANCOV A to test six null hypotheses. Statistically significant differences in HDL cholesterol levels were found between baselin

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9

Mazier, Marie Jeanne Patricia. "Influence of diet fat saturation on rates of cholesterol synthesis and esterification in healthy young men." Thesis, 1994. http://hdl.handle.net/2429/8877.

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To examine the effect of diet fat type on rates of cholesterol synthesis and esterification during feeding and fasting, nine healthy male subjects were fed solid-food diets of 40% fat as predominantly either olive oil (MONO), safflower-oil margarine (POLY), or butter (SAT). At the end of each two-week diet trial, subjects were given deuterium (D) oxide orally and de novo synthesis was measured from D incorporation into cholesterol and interpreted as rates of fractional synthesis (FSR) (pools/day) into the rapidly exchangeable free cholesterol (FC) pool. Absolute synthesis rates (ASR) w

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10

"Effects of octadecaenoic acids and apple polyphenols on blood cholesterol." 2007. http://library.cuhk.edu.hk/record=b5893326.

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Lam, Cheuk Kai.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 148-173).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABSTRACT --- p.ii<br>LIST OF ABBREVIATIONS --- p.vi<br>TABLE OF CONTENTS --- p.x<br>Chapter CHAPTER 1 --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Introduction to Cholesterol and Its Related Diseases --- p.1<br>Chapter 1.1.1 --- Chemistry of cholesterol --- p.1<br>Chapter 1.1.2 --- Physiological importance of cholesterol --- p.1<br>Chapter 1.1.3 --- Pathological effects of cholesterol ---

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"Dietary calcium deficiency and inadequacy elevate blood cholesterol level in hamsters." 2008. http://library.cuhk.edu.hk/record=b5893673.

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Ma, Ka Ying.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references (leaves 113-129).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGMENTS --- p.I<br>ABSTRACT --- p.II<br>LIST OF ABBREVIATIONS --- p.VII<br>TABLE OF CONTENTS --- p.IX<br>Chapter Chapter 1 --- General Introduction --- p.1<br>Chapter 1.1 --- Calcium --- p.1<br>Chapter 1.1.1 --- Recommendation of calcium intake --- p.1<br>Chapter 1.1.2 --- Calcium toxicity --- p.2<br>Chapter 1.1.3 --- Calcium homeostasis --- p.2<br>Chapter 1.1.3.1 --- Role of parathyroid hormone in calcium hom

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"Effect of diet modification on breast cancer development and cholesterol metabolism." 2012. http://library.cuhk.edu.hk/record=b5549086.

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非傳染性疾病是目前全球最常見的疾病之一。不健康的食相信是導致非傳染性疾病增加的主要因素之一。因此，我們就食對乳腺癌的形成和膽固醇代謝調控的影響進行了研究。<br>在去除卵巢的祼鼠模型中，我們研究了長期和短期熱量限制對乳腺癌腫瘤增殖的影響。14週齡的小鼠被隨機分為5組：自由攝食組 (AL)；熱量攝入控制在AL80% 的20%CCR組；熱量攝入控制在AL的70% 的30%CCR組；熱量攝入控制在AL的65% 的35%CCR組和短期熱量限制（SCR）組 (前3.5週熱量攝入控制在AL的65%，之後的13.5週自由攝食)。10週後，熱量限制組的腫瘤體積明顯較AL組小 (P < 0.05)。排除攝食對體重的影響，SCR組的腫瘤重量明顯較AL組小 (P < 0.05)。本實驗結果表明，在此動物模型中，短期熱量限制能有效抑制乳腺癌細胞的增殖。<br>此外，我們還研究了芹菜素在肝細胞中對膽固醇代謝的影響。芹菜素是一種常見的黃酮類化合物。研究發現，在WRL-68細胞中，芹菜素能夠劑量依賴性的抑制3 - 羥基-3 - 甲基 - 戊二酸單酰輔酶還原酶 (HMGCR)和固醇調節元件結合蛋白-2 (SREBP-2) 信使RNA和蛋白的表達及其啟動子的轉錄活性。綜上所述，在肝細胞中，芹菜素能有效抑制HMGCR和SREBP-2的表達，從而達到降低膽固醇的效果。<br>總括而言，本研究表明在去除卵巢的祼鼠模型中

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Codd, Jonathan Richard 1974. "Torpor associated fluctuations in the pulmonary surfactant system in Gould's wattled bat Chalinolobus Gouldii." 2001. http://web4.library.adelaide.edu.au/theses/09SM/09smc669.pdf.

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14

Penque, Brent A. "Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium." Thesis, 2014. http://hdl.handle.net/1805/3805.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Excess caloric intake and/or obesity currently remain the largest predisposing risk factors for the development of type 2 diabetes. Discerning the cellular and molecular mechanisms responsible and amendable to therapy represents a growing challenge in medicine. At a cellular level, increased activity of the hexosamine biosynthesis pathway (HBP), a sensor of excess energy status, has been suggested to promote the exacerbation of insulin resistance through increasing adipose tissue and skeletal muscle membrane cholesterol content. This

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Chang, Chun-Chieh, and 張俊傑. "Effect of fermented soymilk containing N-acetylchitooligosaccharides on immuno-activity and other physiological changes in rats fed on high fat and high cholesterol diets." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/26206852066730144680.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>92<br>This research was intended to investigate the effects of fermented soymilk containing N-acetylchitooligosaccharides on intestinal physiology and immuno-activity of male Wistar rats fed a high fat and a high cholesterol diet (6% corn oil or 10% lard and 0.5% cholesterol). The immuno-activity of fermented product also checked by in vitro experiments. The diets for rats used in the study were divided into four groups: (1) soymilk containing N-acetylchitooligosaccharides (oligomer soymilk), (2) fermented soymilk containing N-acetylchitooligosaccharides (oligomer fe

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Hoffman, Nolan John. "The Effects of Chromium on Skeletal Muscle Membrane/Cytoskeletal Parameters and Insulin Sensitivity." Thesis, 2012. http://hdl.handle.net/1805/2840.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>A recent review of randomized controlled trials found that trivalent chromium (Cr3+) supplementation significantly improved glycemia among patients with diabetes, consistent with a long-standing appreciation that this micronutrient optimizes carbohydrate metabolism. Nevertheless, a clear limitation in the current evidence is a lack of understanding of Cr3+ action. We tested if increased AMP-activated protein kinase (AMPK) activity, previously observed in Cr3+-treated cells or tissues from Cr3+-supplemented animals, mediates improved

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