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Rozprawy doktorskie na temat „Dental Pulp Stromal Cells”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Russell, Hugh. "Early angiogenic change in dental pulp stromal cells cultured on biomimetic matrices." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13395/.

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Revascularisation of the devitalised root canal is the Holy Grail of Endodontics and is being hotly pursued by many teams of clinicians but has yet to be achieved. The overall aim of this work was to attempt to induce early angiogenesis in human dental pulp stromal cells (DPSCS) in vitro and in vivo using a biomimetic approach based on combining scaffolds comprised of ECM components with DPSCs as a first step towards a tissue engineering strategy for dental pulp regeneration. After isolating DPSCs using collagenase digest, they were cultured on 1% hyaluronic acid (HyA) or Types I and III colla

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IEZZI, IOLANDA. "Age-related regenerative potential of human Dental Pulp Stem/Stromal Cells (hDPSCs): possible consequences in an ageing society." Doctoral thesis, Università Politecnica delle Marche, 2020. http://hdl.handle.net/11566/274614.

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Il trattamento efficace della pulpite e/o della parodontite continua ad essere una sfida nella pratica clinica soprattutto in relazione all’invecchiamento della popolazione. Quest’ultimo è un fenomeno fisiologico che si verifica con il tempo e che impedisce la normale funzionalità degli organi, ostacolando l'omeostasi dei tessuti e delle attività fisiologiche. Inoltre, è ben noto che le cellule senescenti influenzano significativamente il loro microambiente, poiché secernono molecole pro-infiammatorie e degradative. Gli approcci di medicina rigenerativa potrebbero soddisfare le necessità di n

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3

Chouaib, Batoul. "Dental pulp stem cell-conditioned medium for tissue regeneration." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT039.

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Le sécrétome des cellules souches mésenchymateuses ou milieu conditionné (MSC-CM), est une combinaison de biomolécules et de facteurs de croissance sécrétés par les cellules souches mésenchymateuses (MSCs) dans un milieu de croissance cellulaire. Les MSC-CM apparaissent comme une alternative efficace à la thérapie cellulaire pour les applications de régénération tissulaire. Cependant, plusieurs questions telles que les protocoles de fabrication doivent être abordées avant l'application clinique de ces produits prometteurs. Dans cette thèse, nous nous sommes concentrés sur les cellules souches

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Collart, Dutilleul Pierre-Yves. "Dental pulp stem cells adhesion, growth and differentiation on porous silicon scaffolds." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON12203/document.

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Le silicium poreux est un biomatériau prometteur pour l'ingénierie tissulaire car il est non toxique et biorésorbable. Des modifications de surface permettent de contrôler sa vitesse de dégradation et peuvent favoriser l'adhésion cellulaire. Les cellules souches de la pulpe dentaire (DPSC) sont des cellules souches mésenchymateuses retrouvées dans la pulpe dentaire, à l'intérieur des dents, et constituent une source accessible de cellules souches. Regrouper les capacités de prolifération et différenciation des DPSC avec les propriétés morphologiques et biochimiques du pSi représente une approc

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Rodrigues, Felipe Valle Fortes. "Avaliação do potencial imunomodulador de células-tronco mesenquimais isoladas a partir de polpa dental, tecido adiposo e medula óssea." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119426.

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Introdução: Células tronco mesenquimais (CTM) são uma população residente nos tecidos adultos de origem mesodérmica, com funções regenerativas de manutenção da integridade tecidual, com destaque no desempenho imunomodulador. Esse aspecto levou as CTM a tornarem-se ferramentas terapêuticas valiosas da pesquisa à assistência ao paciente em doenças autoimunes e de cunho inflamatório. Além disso, CTM podem ser isoladas de materiais tidos como descarte de procedimentos, como dentes decíduos, filtros de transplante de medula óssea e gordura. Nesse panorama, torna-se necessário estabelecer o efeito q

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6

Souron, Jean-Baptiste. "Régénération de la pulpe dentaire par ingénierie tissulaire : mise au point d’une «pulpe équivalente»." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T059/document.

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La pulpe dentaire est sujette à des lésions sévères faisant suite à une carie dentaire ou à un traumatisme. La thérapeutique conventionnelle préconisée alors est le traitement endodontique, qui consiste en l’exérèse de la totalité de la pulpe dentaire et le comblement de l’espace pulpaire par un matériau inerte. Ce traitement induit une fragilisation de la dent et une plus grande susceptibilité aux infections. Au cours de ce travail, nous avons mis au point une solution alternative, en proposant le remplacement de la pulpe dentaire lésée par une « pulpe équivalente » constituée de cellules sou

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7

Dissanayaka, Waruna Lakmal. "Synergistic effects of dental pulp stem cells and endothelial cells in pulp regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197085.

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Regeneration of the tissues to replace diseased, missing and traumatized dentin/pulp requires combining the recent progress in stem cell and tissue engineering research. Dental pulp stem cells (DPSCs) are considered as a promising population of cells in regenerative dentistry and shown to be able to produce dentin/pulp-like tissues following implantation in-vivo. Securing a good blood supply is critical in pulp regeneration, however, this is a challenging task due to the unique structure of the tooth, the anatomy of which permits only a microcirculatory system via a very small apical opening (

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8

Ravenscroft, Harriet. "Defence mechanisms of dental pulp stem cells." Thesis, Queen's University Belfast, 2018. https://pure.qub.ac.uk/portal/en/theses/defence-mechanisms-of-dental-pulp-stem-cells(0e1880c7-13b4-4072-86c6-4b52a05d5175).html.

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9

El-Gendy, Reem Omar Othman Mostafa. "Bone tissue engineering using dental pulp stem cells." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535682.

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10

Pang, Y. W. Y. "Functional characteristics of dental pulp mesenchymal stem cells." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1465057/.

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Mesenchymal stem cells (MSCs) in many adult tissues provide cell sources to sustain tissue growth and/or repair in vivo, yet MSCs are mainly studied based on their in vitro characteristics. One emerging population of such MSCs are from dental pulp mesenchymal tissue, termed dental pulp stem cells (DPSCs). For instance, the continuously growing rodent incisor model has recently provided the first in vivo evidence that the in vivo identities of MSCs are of multiple origins including from perivascular niches. However, little is known about the molecular mechanisms underlying MSC response to injur

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11

Gil, Recio Carlos. "Obtaining hepatocyte-like cells from dental pulp pluripotent-like stem cells." Doctoral thesis, Universitat Internacional de Catalunya, 2015. http://hdl.handle.net/10803/299800.

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The liver is the largest internal organ and an important regulator of homeostasis providing essential metabolic, exocrine and endocrine functions. Liver diseases result in high rates of morbidity and mortality and affect a growing number of people over the years. Obtaining mature hepatocytes from stem cells is a major goal in regenerative medicine studies due to the clinical applications that could derive from it. Dental pulp pluripotent stem cells are a considerable promise in tissue engineering and regenerative medicine as a source of tissue-specific cells, therefore the aim of this study is

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12

Alkharobi, Hanaa. "Characterisation of dental pulp cells derived from carious teeth." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15341/.

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This study investigated some characteristics of dental pulp stromal/stem cells (DPSCs) isolated from healthy teeth (hDPSCs) compared to DPSCs isolated from teeth with shallow carious lesions (cDPSCs) with a view to the use of both cell types in hard tissue engineering strategies. Osteogenic differentiation was investigated using appropriate histochemical staining and osteogenic marker expression (ALPL, OC, RUNX-2). In addition, angiogenic (VEGFR-2, PECAM-1) and inflammatory gene markers (TLR-2, TLR-4) were investigated together with the secretion of the pro-inflammatory cytokines (IL-6 and IL-

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13

Abd-Elmotelb, Mona Assem Mahrous. "Thy-1(CD90) expression in dental pulp stem cells." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/thy1cd90-expression-in-dental-pulp-stem-cells(3ab664e1-d191-49e5-8f0b-0f1a8708a374).html.

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The search for mesenchymal stem cells (MSCs) in adult tissues had led to the discovery of stem cells in many tissues in the body, including teeth. A better understanding of the biology of dental stem cell populations is a pre-requisite to allow their future use for clinical purposes. To understand the biology of stem cell niches in the dental pulp, new genes expressed in dental tissues that could serve as markers of dental stem cells were investigated. The mouse incisor differs from mouse molars as well as human teeth in that it erupts continuously throughout the life of the animal. This conti

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14

Chu, Rene. "Age and Sex-Related Differences in Dental Pulp Stem Cells." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4830.

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Objective: An in vitro study to determine the age and gender related changes of dental pulp stem cells in regards to proliferative capacity and lineage dependent effects on differentiation capabilities. Material and Methods: Specimens have been collected from a population ranging from 16 yrs of age to 78 yrs of age. Intact, non-carious teeth were collected from the oral surgery department at College of Dentistry at the University of Iowa. A total of 20 specimens were collected. Teeth were collected, sectioned and pulpal tissue collect

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15

Zer, Heba al [Verfasser], and Ralf [Akademischer Betreuer] Smeets. "Enrichment and Characterization of Neural Crest - derived Dental Pulp Stem Cells from Human Dental Pulp / Heba Al-Zer. Betreuer: Ralf Smeets." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/106893154X/34.

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16

Solis, Castro Oscar Omar. "Characterisation of mouse and human dental pulp cells for auditory regeneration." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22515/.

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Modern-day regenerative medicine is constantly exploring the development and application of stem cells for cell-based therapies in many conditions and diseases. One of such conditions is deafness, which affects over 360 million people worldwide, frequently caused by irreversible damage to the sensory cells. Therapies which could replace dead or damaged spiral ganglion neurons in deafness are sought as alternatives to the currently limited approaches. In this regard, stem cells from human dental pulp cells (hDPCs) are proposed to be intrinsically neurogenic due to their neural crest origin. Nev

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17

Lee, Chi. "Commitment and potential of dental pulp stem cells : their role in directing dental tissue regeneration." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/20156/.

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Dental pulp stem cells (DPSCs) play an integral role during dentine injury where they migrate towards the injury site, proliferate, differentiate into odontoblast-like cells and secrete a mineralised matrix, protecting the vital pulp tissue and preserving the tooth organ. Dentine matrix proteins (DMP) may have a role in stimulating this reparative dentine formation. Multiple adult stem cells make up the DPSC population. Within this study progenitor cells were isolated from dental pulp by preferential fibronectin adherence (FNA) or using magnetic activated cell sorting (MACS) to isolate P75 exp

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18

Ducret, Maxime. "Ingénierie tissulaire de la pulpe dentaire : vers le développement d’un médicament de thérapie innovante." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10335/document.

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Ces dernières années, des thérapies à base de cellules mésenchymateuses ont été développées pour améliorer les thérapies qui visent à réparer l'homme et notamment la pulpe dentaire. Dans ce contexte, la dent apparait comme la source de cellules mésenchymateuses, souches ou progénitrices, permettant de réparer la pulpe dentaire. En effet, la pulpe dentaire est facile d'accès et les cellules pulpaires présentent un fort potentiel de différenciation. Actuellement, les différents organismes de contrôle recommandent d'utiliser des procédures standardisées pour l'isolement, le stockage et l'expansio

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19

Gale, Zoe. "Glial cell line-derived neurotrophic factor effects on dental pulp cells and osteoblast-like cells." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3268/.

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Glial cell line-derived neurotrophic factor (GDNF) is a growth factor promoting survival, proliferation and differentiation of neural crest cells. Neural crest cells play an important role within mesenchymal tissues during dental pulp and calvarial bone development. GDNF also has a role within non-neuronal tissues and is expressed during dental development. GDNF null mutations prevent the formation of the mineralised hard tissues of the tooth. The hypothesis for this study was that GDNF affects mesenchymal dental pulp cells (DPC), promoting the regenerative responses of mineralised tissues. Th

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20

Zamorano, Mosnaim Mauricio. "Human dental pulp stem cells : characterisation and in vitro 3D bone ontogeny." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/41971.

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Tissue engineering has emerged as a practical approach to tackle with the prosthetic industry limitations. Its methods merge aspects from developmental biology, engineering, material sciences and medicine, with the aim to produce fully-functional bone tissue ex vivo, to further replacement or regeneration of real bone injuries and/ or defects. Traditional bone tissue engineering cell culture technique, includes the seeding of SCs in three-dimensional matrices, cultured in fed-batch rotating bioreactors, working jointly with biological cues to produce biomimics. Nonetheless, fed-batch bioproces

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21

Rezapour, Mehrnoosh. "Comparison of the effects of different pulp capping materials on viability, morphology and ageing of dental pulp cells." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9236/.

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A significant amount of research has been directed towards the development of minimally invasive and/or regenerative therapeutic approaches to the maintenance of dental pulp vitality. Direct pulp capping is an example of such a therapeutic approach where the success of the treatment is largely affected by the biological characteristics of pulp capping agent. Tissue engineering approaches also include the use of human dental pulp cells (HDPCs) seeded on biocompatible scaffolds to regenerate lost hard, or soft dental tissues. Such processes may require a large number of cells which can only be p

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Young, Fraser. "Dental pulp progenitor-derived neuronal- and oligodendrocyte-like cells for spinal cord repair." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/53879/.

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Spinal cord regeneration following injury represents a major clinical challenge. Over recent years, stem cells have demonstrated promise for promoting spinal repair in the lab and in early stage clinical trials through functional replacement of neuronal and glial cells and through secondary trophic mechanisms to promote endogenous regeneration. Research has primarily focused on the use of embryonic tissue-derived stem cells of potentially limited therapeutic application due to related ethical concerns. The dental pulp harbours a source of easily accessible progenitor cells that have demonstrat

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Liu, Yuan, and 刘源. "Regulation of dental pulp stem cell's anti-apoptotic ability and proliferation through over-expression of Bcl-2." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209477.

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The pulp organ is retained in the pulp chamber of teeth and maintains the biological and physiological vitality of the surrounding dentin. It works as a biosensor and generates secondary dentine and tertiary dentine to resist tooth abrasion and pathogenic stimuli (Zhang and Yelick, 2010). However, dental pulp is vulnerable to injury (Smulson and Sieraski, 1989). Most people experience some irreversible pulpal diseases during their lifetime. Hence, pulp regeneration is one of the research tasks in dentistry that attracts much attention. Stem cell transplantation is a plausible strategy for t

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Saoji, Nachiket A. "Effect of bisphosphonate on osteogenic differentiation of pulp and PDL cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/saoji.pdf.

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Martínez, Sarrà Ester. "Characterization of Dental Pulp Pluripotent-like Stem Cells (DPPSC) and their mesodermal differentiation potential." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/402610.

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Dental pulp represents an easily accessible autologous source of adult stem cell populations. Among them, a population named dental pulp pluripotent-like stem cells (DPPSC) has been isolated from the dental pulp of human third molars and express pluripotency markers such as OCT3/4 and SOX2. DPPSC show pluripotent-like behaviour differentiating in vitro into tissues of the three embryonic layers and being able to form teratoma-like structures. This population also represents a source of adult stem cells without the ethical controversy or safety issues that are associated with the use of embryon

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Smith, Michael James. "Utilising mesenchymal stem cells from adipose tissue and dental pulp for epithelial tissue engineering." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7394/.

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Current treatment of epithelial wounds utilise biomimetic materials, cells or a combination of both. This project aimed to examine the feasibility of incorporating mesenchymal stem cells (MSCs), isolated from adipose tissue and dental pulp, and induced pluripotent stem cells (iPSC)-derived cells into 3D organotypic cultures, as reports suggest MSCs facilitate wound healing and can generate constituent cells. The effect collagen hydrogels containing MSCs on H400 epithelial cells seeded on its surface was assessed. Fixed H&E-stained sections of organotypic cultures were used to determine epithel

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Zou, Huiru. "The effect of enamel matrix protein on the odotogenic differentiation of dental pulp stem cells." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536087.

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Rizk, Ahmed El Sayed Mahmoud. "Human dental pulp stem cells expressing TGF{221}-3 transgene for cartilage-like tissue engineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47752890.

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A major challenge facing the tissue engineering discipline is cartilage tissue repair and engineering, because of the highly specialized structure and limited repair capacity that cartilage possesses. Dental pulp stem cells (DPSCs) were identified about a decade ago as a potential candidate for cell based therapy and tissue engineering applications. The present study aimed to utilize gene therapy with isolated DPSCs to induce chondrogenic transgene expression and chondrogenic lineage differentiation, with the ultimate goal of engineering cartilage tissue-like constructs. We isolated D

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Kushnerev, Evgeny. "Dental pulp stem cells : investigations into methods of enhancing regeneration and repair of the cornea." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/dental-pulp-stem-cells--investigations-into-methods-of-enhancing-regeneration-and-repair-of-the-cornea(d2b05828-99df-4913-a1cf-1b080d2ec3bf).html.

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The cornea is the transparent, avascular and highly innervated outer anterior layer of the eye. The cornea is a very delicate structure and any traumatic insult may lead to damage and limbal stem cell deficiency (LSCD), leading to chronic discomfort, visual impairment and ultimately blindness. The resultant issues can have a significant effect on patients and reduce their quality of life. Whilst conservative and therapeutic management of these problems play a part in the treatment of corneal injuries often surgery is indicated. However, surgical repair of damaged corneas may be limited by the

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Sime, Wondossen. "The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-122-7/.

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Bucchi, Morales María Cristina. "Experimental Approaches for Pulp Tissue Regeneration." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668228.

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The aim of this PhD thesis was to study experimental approaches for revitalization of necrotic teeth. Revitalization, also known as regenerative endodontic procedures (REPs), is a relatively new treatment for necrotic teeth which tries to regenerate the dentine-pulp complex instead of obturating the root canal with biologically inert materials (root canal treatment). Until very recently, the most reliable option for the treatment of immature necrotic teeth was apexification followed by root canal treatment. However, endodontically treated teeth remain devitalized throughout the patient's lifet

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Karbanová, Jana, Tomáš Soukup, Jakub Suchánek, Robert Pytlík, Denis Corbeil, and Jaroslav Mokrý. "Characterization of Dental Pulp Stem Cells from Impacted Third Molars Cultured in Low Serum-Containing Medium." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136045.

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We isolated and expanded stem cells from dental pulp from extracted third molars using an innovative culture method consisting of low serum-containing medium supplemented with epidermal growth factor and platelet-derived growth factor BB. We evaluated the differentiation potential of these cells when they were growing either adherently or as micromass/spheroid cultures in various media. Undifferentiated and differentiated cells were analyzed by flow cytometry, immunocytochemistry and immunoblotting. The flow cytometry results showed that the dental pulp stem cells (DPSCs) were positive for mes

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Tomson, Phillip Leo. "Dentine extracellular matrix components liberated by calcium silicate cements and their effects on dental pulp cells." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4212/.

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Although the regenerative capacity of the dentine-pulp complex, induced by pulp capping agents, is well established, the molecular processes by which this occurs, are poorly understood. Calcium silicate cements are powerful stimulators of wound healing in the pulp. This project aimed to investigate the potential of calcium silicate cements to liberate dentine extracellular matrix (dECM) components, characterise growth factors present and determine if these dECM components, or any specific growth factor characterised, had bioactive effects on pulp wound healing. dECM was solubilised from human

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Karbanová, Jana, Tomáš Soukup, Jakub Suchánek, Robert Pytlík, Denis Corbeil, and Jaroslav Mokrý. "Characterization of Dental Pulp Stem Cells from Impacted Third Molars Cultured in Low Serum-Containing Medium." Karger, 2011. https://tud.qucosa.de/id/qucosa%3A27697.

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We isolated and expanded stem cells from dental pulp from extracted third molars using an innovative culture method consisting of low serum-containing medium supplemented with epidermal growth factor and platelet-derived growth factor BB. We evaluated the differentiation potential of these cells when they were growing either adherently or as micromass/spheroid cultures in various media. Undifferentiated and differentiated cells were analyzed by flow cytometry, immunocytochemistry and immunoblotting. The flow cytometry results showed that the dental pulp stem cells (DPSCs) were positive for mes

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35

ANDO, YUSUKE, MASAKI J. HONDA, HAYATO OHSHIMA, et al. "THE INDUCTION OF DENTIN BRIDGE-LIKE STRUCTURES BY CONSTRUCTS OF SUBCULTURED DENTAL PULP-DERIVED CELLS AND POROUS HA/TCP IN PORCINE TEETH." Nagoya University School of Medicine, 2009. http://hdl.handle.net/2237/11336.

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Harrington, Jodie. "Efficacy of clonal progenitor cells from dental pulp and bone marrow to regenerate craniofacial mineralised tissue structures." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/66871/.

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The current clinical choice for bone regeneration is autologous bone grafts from the iliac crest. The associated drawbacks, however, in terms of morbidity and low cell number following tissue harvest, have led to search for alternative stromal cell sources in conjunction with native tissue matrix components. For mineralised tissue engineering, alternative to mesenchymal bone marrow stromal cells (BMSCs), mesenchymal dental pulp stromal cells (DPSCs) have been proposed due to high colony formation and differentiation potential. Understanding which stromal population is exemplar for rapid and ef

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Chatakun, Punjamaporn. "The Effect of 5 Proteins On DPPSC (Dental Pulp Pluripotent Stem Cells) For Osteoblast Differentiation Proliferation In 3D." Doctoral thesis, Universitat Internacional de Catalunya, 2014. http://hdl.handle.net/10803/277382.

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Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopaedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp (DPSC). The aim of this research is to determine the relationship among the proteins fibronectin (FN), bone morphogenetic protein 2 (BMP2) osteopontin (OPN), tenascin C (TNC) and bone sialoprotein (BSP) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiat

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Núñez, Toldrà Raquel. "Osteogenic differentiation strategies of Dental Pulp Pluripotent-like Stem Cells (DPPSC) for their potential application in Bone Tissue Engineering." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/454748.

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Actualment, els defectes ossis, ja sigui deguts a traumes o a malalties, afecten a milions de persones a nivell mundial, fet que suposa una demanda constant al sistema sanitari per al reemplaçament o la restitució d’os. En els últims anys, les tècniques de medicina regenerativa i d’enginyeria tissular d’ós que combinen l’ús de biomaterials, cèl·lules i factors de creixement, han esdevingut un recurs terapèutic molt prometedor per al tractament de defectes ossis. Les cèl·lules mare pluripotents poden ser de gran valor en enginyeria tissular degut al seu potencial d’auto-renovació, la seva alta

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Murtra, Sada Maria Cristina. "Evaluación de la Capacidad Osteogénica de las DPPSC (Dental Pulp Pluripotent Stem Cells) sobre diferentes superficies y Biocoating para validar una nueva superfie de Implante Dental." Doctoral thesis, Universitat Internacional de Catalunya, 2014. http://hdl.handle.net/10803/133080.

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Cuando tenemos un implante de Ti convencional, la calidad de su superficie es el pilar fundamental para la osteointegración debido a que sus características topográficas y químicas, son las que controlan la conformación de su capa proteica, y con ello, el sistema de comunicación entre célula-proteína-implante que guiará hacia la deseada osteointegración. Pero en el momento en que a ese implante de Ti convencional se le añade un biocoating, su superficie bioinerte (Ti) se convierte en una superficie bioactiva, donde las biomoléculas que la conforman pasan a ser las activadoras del sistema de co

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Miura, Carlos Akio Saback. "Efeito do laser de baixa potência sobre células tronco de polpa de dentes decíduos esfoliados humanos (SHED)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/25/25145/tde-11042015-091403/.

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Avaliou-se a proliferação das células tronco da polpa de dentes decíduos esfoliados humanos (SHED) após aplicação única do laser de baixa potência. Foi realizada a análise da viabilidade das SHED cultivadas sob déficit nutricional e em condições ideais após irradiação com o laser de baixa potência vermelho de Indio Gálio Alumínio e Fósforo - InGaAlP (660nm, 40mW e 10J/cm2) e infravermelho (780nm, 40mW e 10J/cm2) durante 4 e 8 segundos, nos períodos de 24, 48 e 72 horas através dos ensaios de redução do MTT e do ensaio colorimétrico de Busatti e Gomes. Para análise estatística utilizou-se o tes

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Gangolli, Riddhi Ajit. "A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/409954.

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Bioengineering<br>Ph.D.<br>60 % of school children have some form of untreated tooth decay or have suffered trauma to the front teeth which results in pulp damage. If left untreated, these teeth are susceptible to premature fracture/loss under daily stresses. In cases of adolescent tooth loss, teenagers cannot get dental implants until after the growth spurts; their only option is using removable dentures which lowers their quality of life. Conventional endodontic treatment (root canal treatment) is used in cases of pulp necrosis, but cannot be performed in immature permanent teeth due to majo

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Luiz, Lucyene Miguita. "Células-tronco mesenquimais: isolamento e caracterização de populações derivadas de alvéolo dental humano e identificação e caracterização de populações de polpas dentais de camundongos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-20022014-162745/.

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Há um grande interesse no estudo de células-tronco em função de sua capacidade de auto-renovação e plasticidade. Estas características capacitam as células-tronco a produzirem células de diferentes linhagens que participam ativamente do processo de homeostase, da resposta à injúria e da regeneração e reparação tecidual. A polpa dental é o tecido mais estudado na Odontologia em relação a células-tronco, mas diversos estudos já mostraram a presença dessas células também na região periodontal. É importante salientar, que dependendo de sua origem, as células-tronco apresentam comportamentos divers

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CRISTALDI, Marta. "In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) by use of nanostructured scaffolds." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/394616.

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Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth,

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Bento, Leticia Westphalen. "Mecanismos moleculares envolvidos na diferenciação das SHED (Stem Cells from Exfoliated Deciduous Teeth) em células endoteliais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/63157.

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As células-tronco provenientes da polpa de dentes decíduos esfoliados (SHED) são uma fonte promissora de células-tronco para a terapia regenerativa. Já foi demonstrado que elas podem se diferenciar em células endoteliais, mas os mecanismos envolvidos nesse processo ainda são desconhecidos. Dessa forma, o presente estudo teve como objetivo elucidar os mecanismos moleculares relacionados à diferenciação endotelial dessas células. Para isso, um meio de cultura para células endoteliais (EGM-2MV), suplementado por 50ng/mL rhVEGF, foi utilizado com sucesso como estímulo para as SHED se diferenciarem

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Santos, Ana Rita Caseiro. "Cell-based therapies in regenerative medicicne: the therapeutic potential of umbilical cord and dental pulp derived stem/stromal cells." Doctoral thesis, 2020. https://hdl.handle.net/10216/126262.

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Chang, Yi-Tan, and 張懿丹. "Dental pulp tissue regeneration by deciduous pulp stem cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/00740543171877725167.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>96<br>Periodontal diseases、caries、trauma or cancer are common causes for tooth decay or tooth loss. A biological tooth substitute that could replace decayed tooth or lost tooth would provide a vital alternative to currently available clinical therapy. The aim of the study was to utilize deciduous dental pulp stem cells and tissue engineering method to regenerate injured dental pulp. By using enzyme digestion, dental pulp stem cells could be isolated from deciduous teeth. These cells have capacity to generate clongenic cell clusters in culture. They were also identi

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Chao-AnChen and 陳昭安. "Effects of Dental Restorative Materials on Human Dental Pulp Stem Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/42772244992756799745.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>102<br>Numerous studies have approved the significance of DPSC since it may differentiate into various cells to support tissue engineering and stem cell therapy. The source teeth are frequently filled with material including composite resin, glass ionomer, and zinc oxide eugenol-base materials, due to caries. Cytotoxicity and genotoxicity of these restorative materials have been well-documented in in vitro studies. However, only some of these compounds were also found to diffuse through the dentinal tubules and reach the pulp tissue, even in the presence of an intact

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Stokowski, Agnieszka. "Guidance and neuronal properties of dental pulp stem cells." 2007. http://hdl.handle.net/2440/59622.

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Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library.<br>Human adult dental pulp cells (DPSC) reside within the perivascular niche of dental pulp and are thought to originate from migrating cranial neural crest (CNC) cells. During development, CNC cells respond to the environmental cues to migrate and differentiate into the different cell types that contribute to the formation of craniofacial structures and the peripheral nervous system. The Eph family of receptor tyrosine kinases and their ligands, the ephrin

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Lee, Mon-Ying, та 李夢瑩. "Pathobiological Functions of PGF2α on human dental pulp cells". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/45315882538001700412.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>94<br>Previous studies have found that the amount of PGF2α amount in human dental pulp raise during inflammation. However the roles and effects of PGF2α in human dental pulp are not fully clear. The aim of this research was to evaluate the effects of PGF2α on human dental pulp cells in vitro. We found that primary human dental pulp cells expressed FP receptor as analyzed by reverse transcriptase polymerase chain reaction (RT-PCR). Activation of FP receptor by PGF2α (10μM) induced both ERK and CREB phosphorylation in pulp cells as shown by western blotting. Exposure

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Huang, Feng-Ju, and 黃鳳茹. "Effects of cathelicidin (LL37) on human dental pulp cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/50254443235330120502.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>101<br>Dental caries is one of the most common infectious diseases which may cause demineralization and destruction of the hard tissues and pulp inflammation. With the discovery of regenerative potential of the dental pulp, there is a shift on the treatment of pulpal inflammation to a more conservative approach. The antimicrobial peptide LL37 (cathelicidin), which is part of the innate immune system, has been suggested for the regenerative procedures due to the ability to defense against pathogens and regulate wound healing. However, little was known about the expres

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