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Artykuły w czasopismach na temat „Dental Pulp Stromal Cells”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Grawish, Mohammed E. "Human dental pulp stem/stromal cells in clinical practice." World Journal of Stem Cells 16, no. 2 (2024): 54–57. http://dx.doi.org/10.4252/wjsc.v16.i2.54.

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Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical concerns and can be successfully cryopreserved and thawed. The therapeutic effects of DPSCs derived from animal or human sources have been extensively studied through in-vitro and in-vivo animal experiments and the findings indicated that DPSCs are effective not only for dental diseases but also for systemic diseases. Understanding that translational research

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Pagella, Pierfrancesco, César Nombela-Arrieta, and Thimios A. Mitsiadis. "Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth." International Journal of Molecular Sciences 22, no. 6 (2021): 3024. http://dx.doi.org/10.3390/ijms22063024.

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Specific stem cell populations within dental mesenchymal tissues guarantee tooth homeostasis and regeneration throughout life. The decision between renewal and differentiation of stem cells is greatly influenced by interactions with stromal cells and extracellular matrix molecules that form the tissue specific stem cell niches. The Cxcl12 chemokine is a general marker of stromal cells and plays fundamental roles in the maintenance, mobilization and migration of stem cells. The aim of this study was to exploit Cxcl12-GFP transgenic mice to study the expression patterns of Cxcl12 in putative den

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3

Afami, Marina E., Ikhlas El Karim, Imad About, Anna D. Krasnodembskaya, Garry Laverty, and Fionnuala T. Lundy. "Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp." Pharmaceutics 13, no. 10 (2021): 1575. http://dx.doi.org/10.3390/pharmaceutics13101575.

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In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied extensively for their ability to inhibit micro-organisms relevant to tissue engineering sites such as dental root canals. In this work, we assess the biocompatibility of dental pulp stem/stromal cells with commercially available multicomponent peptide hydrogels. We also determine the effects of dental pulp stem/stromal cell (DPSC) culture in hydrogels on growth

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Lee, S., H. J. Yoon, Y. S. Sohn, Y. W. Choi, and N. H. Park. "P.423 Mesenchymal stromal cells from dental pulp." Journal of Cranio-Maxillofacial Surgery 36 (September 2008): S273. http://dx.doi.org/10.1016/s1010-5182(08)72211-x.

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Nakashima, M., and K. Iohara. "Regeneration of Dental Pulp by Stem Cells." Advances in Dental Research 23, no. 3 (2011): 313–19. http://dx.doi.org/10.1177/0022034511405323.

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Angiogenesis/vasculogenesis and neurogenesis are essential for pulp regeneration. Two subfractions of side-population (SP) cells, CD31-/CD146- SP cells and CD105+ cells with angiogenic and neurogenic potential, were isolated by flow cytometry from canine dental pulp. In an experimental model of mouse hindlimb ischemia, transplantation of these cell populations resulted in an increase in blood flow, including high-density capillary formation. In a model of rat cerebral ischemia, stem cell transplantations enhanced neuronal regeneration and recovery from motor disability. Autologous transplantat

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6

Chung, Choo-Ryung, Ha-Na Kim, Yeul Park, et al. "Morphological evaluation duringin vitrochondrogenesis of dental pulp stromal cells." Restorative Dentistry & Endodontics 37, no. 1 (2012): 34. http://dx.doi.org/10.5395/rde.2012.37.1.34.

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Marchionni, C., L. Bonsi, F. Alviano, et al. "Angiogenic Potential of Human Dental Pulp Stromal (STEM) Cells." International Journal of Immunopathology and Pharmacology 22, no. 3 (2009): 699–706. http://dx.doi.org/10.1177/039463200902200315.

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Astakhova, V. S. "Cloning of stromal precursor cells from human dental pulp." Biopolymers and Cell 8, no. 4 (1992): 48–50. http://dx.doi.org/10.7124/bc.00032f.

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9

Strub, M., L. Keller, Y. Idoux-Gillet, et al. "Bone Marrow Stromal Cells Promote Innervation of Bioengineered Teeth." Journal of Dental Research 97, no. 10 (2018): 1152–59. http://dx.doi.org/10.1177/0022034518779077.

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Transplantation of bone marrow mesenchymal stem cells (BMDCs) into a denervated side of the spinal cord was reported to be a useful option for axonal regeneration. The innervation of teeth is essential for their function and protection but does not occur spontaneously after injury. Cultured reassociations between dissociated embryonic dental mesenchymal and epithelial cells and implantation lead to a vascularized tooth organ regeneration. However, when reassociations were coimplanted with a trigeminal ganglion (TG), innervation did not occur. On the other hand, reassociations between mixed emb

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10

Winderlich, Joshua N., Karlea L. Kremer, and Simon A. Koblar. "Adult human dental pulp stem cells promote blood–brain barrier permeability through vascular endothelial growth factor-a expression." Journal of Cerebral Blood Flow & Metabolism 36, no. 6 (2015): 1087–97. http://dx.doi.org/10.1177/0271678x15608392.

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Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood–brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood–brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood–brain barrier. This effect w

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11

Tancharoen, Salunya, Tassanee Tengrungsun, Theeralaksna Suddhasthira, et al. "Overexpression of Receptor for Advanced Glycation End Products and High-Mobility Group Box 1 in Human Dental Pulp Inflammation." Mediators of Inflammation 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/754069.

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High mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is released into the extracellular space and promotes inflammation. HMGB1 binds to related cell signaling transduction receptors, including receptor for advanced glycation end products (RAGE), which actively participate in vascular and inflammatory diseases. The aim of this study was to examine whether RAGE and HMGB1 are involved in the pathogenesis of pulpitis and investigate the effect of Prevotella intermedia (P. intermedia) lipopolysaccharide (LPS) on RAGE and HMGB1 expression in odontoblast-like cells (OLC-1). RAGE and H

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12

Suárez-Franco, J. L., B. I. Cerda-Cristerna, L. Tejeda-Jácome, G. Suárez-Franco, J. Romero-Ricavar, and M. A. Álvarez-Pérez. "Biological characterization of dental pulp stromal cells onto PMMA scaffolds." Dental Materials 34 (2018): e119. http://dx.doi.org/10.1016/j.dental.2018.08.248.

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Tan, Qin, Yuying Cao, Xiaorong Zheng, Mengtian Peng, Enyi Huang, and Jinhua Wang. "BMP4-regulated human dental pulp stromal cells promote pulp-like tissue regeneration in a decellularized dental pulp matrix scaffold." Odontology 109, no. 4 (2021): 895–903. http://dx.doi.org/10.1007/s10266-021-00620-5.

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14

Yu, Jinhua, Yijing Wang, Zhihong Deng, et al. "Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells." Biology of the Cell 99, no. 8 (2007): 465–74. http://dx.doi.org/10.1042/bc20070013.

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Basok, Yu B., A. M. Grigoriev, L. A. Kirsanova, et al. "The comparative study of chondrogenic differentiation of mesenchymal stromal cells allocated from different sources." Russian Journal of Transplantology and Artificial Organs 21, no. 1 (2019): 101–12. http://dx.doi.org/10.15825/1995-1191-2019-1-101-112.

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Introduction. As an alternative to autochondral transplantation, variants of chondrocyte replacement with mesenchymal stromal cells (MSCs) were considered, since these cells are present in all organs and tissues of human body and possess multilinear potential for differentiation. A number of studies demonstrate that the ability for chondrogenic differentiation of MSCs from different tissues varies, however, those studies are few and controversial. In accordance with the ethical principles and the technical ease of obtaining, adipose tissue, Wharton’s jelly (stroma) and dental pulp are the most

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16

Harichane, Y., A. Hirata, S. Dimitrova-Nakov, et al. "Pulpal Progenitors and Dentin Repair." Advances in Dental Research 23, no. 3 (2011): 307–12. http://dx.doi.org/10.1177/0022034511405322.

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Mesenchymal stem cells are present in the dental pulp. They have been shown to contribute to dentin-like tissue formation in vitro and to participate in bone repair after a mandibular lesion. However, their capacity to contribute efficiently to reparative dentin formation after pulp lesion has never been explored. After pulp exposure, we have identified proliferative cells within 3 zones. In the crown, zone I is near the cavity, and zone II corresponds to the isthmus between the mesial and central pulp. In the root, zone III, near the apex, at a distance from the inflammatory site, contains mi

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17

Stanko, Peter, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, and Cestmir Altaner. "Dental Mesenchymal Stem/Stromal Cells and Their Exosomes." Stem Cells International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8973613.

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Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes. The therapeutic applicability of these cells and exosomes in denta

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18

Datko Williams, Laura, Amanda Farley, Matthew Cupelli, Satish Alapati, Marian S. Kennedy, and Delphine Dean. "Effects of substrate stiffness on dental pulp stromal cells in culture." Journal of Biomedical Materials Research Part A 106, no. 7 (2018): 1789–97. http://dx.doi.org/10.1002/jbm.a.36382.

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Zhu, Lifang, Waruna Lakmal Dissanayaka та Chengfei Zhang. "Dental pulp stem cells overexpressing stromal-derived factor-1α and vascular endothelial growth factor in dental pulp regeneration". Clinical Oral Investigations 23, № 5 (2018): 2497–509. http://dx.doi.org/10.1007/s00784-018-2699-0.

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Syed-Picard, Fatima N., Yiqin Du, Kira L. Lathrop, Mary M. Mann, Martha L. Funderburgh, and James L. Funderburgh. "Dental Pulp Stem Cells: A New Cellular Resource for Corneal Stromal Regeneration." STEM CELLS Translational Medicine 4, no. 3 (2015): 276–85. http://dx.doi.org/10.5966/sctm.2014-0115.

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Rusu, M. C., C. Loreto, A. Sava, V. Mănoiu, and A. C. Didilescu. "Human adult dental pulp CD117/c-kit-positive networks of stromal cells." Folia Morphologica 73, no. 1 (2014): 68–72. http://dx.doi.org/10.5603/fm.2014.0009.

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Snyder, Brooke R., Pei-Hsun Cheng, Jinjing Yang, Shang-Hsun Yang, Anderson HC Huang, and Anthony WS Chan. "Characterization of dental pulp stem/stromal cells of Huntington monkey tooth germs." BMC Cell Biology 12, no. 1 (2011): 39. http://dx.doi.org/10.1186/1471-2121-12-39.

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Kok, Zi Y., Nadia Y. A. Alaidaroos, Amr Alraies, et al. "Dental Pulp Stem Cell Heterogeneity: Finding Superior Quality “Needles” in a Dental Pulpal “Haystack” for Regenerative Medicine-Based Applications." Stem Cells International 2022 (January 4, 2022): 1–20. http://dx.doi.org/10.1155/2022/9127074.

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Human dental pulp stem/stromal cells (hDPSCs) derived from the permanent secondary dentition are recognised to possess certain advantageous traits, which support their potential use as a viable source of mesenchymal stem/stromal cells (MSCs) for regenerative medicine-based applications. However, the well-established heterogeneous nature of hDPSC subpopulations, coupled with their limited numbers within dental pulp tissues, has impeded our understanding of hDPSC biology and the translation of sufficient quantities of these cells from laboratory research, through successful therapy development a

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Sonoda, Soichiro, and Takayoshi Yamaza. "A New Target of Dental Pulp-Derived Stem Cell-Based Therapy on Recipient Bone Marrow Niche in Systemic Lupus Erythematosus." International Journal of Molecular Sciences 23, no. 7 (2022): 3479. http://dx.doi.org/10.3390/ijms23073479.

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Recent advances in mesenchymal stem/stromal cell (MSC) research have led us to consider the feasibility of MSC-based therapy for various diseases. Human dental pulp-derived MSCs (hDPSCs) have been identified in the dental pulp tissue of deciduous and permanent teeth, and they exhibit properties with self-renewal and in vitro multipotency. Interestingly, hDPSCs exhibit superior immunosuppressive functions toward immune cells, especially T lymphocytes, both in vitro and in vivo. Recently, hDPSCs have been shown to have potent immunomodulatory functions in treating systemic lupus erythematosus (S

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25

Kasahara, Yuko N., Mutsuki Kuraoka, Hiromi H. Kinoh, et al. "238. Cell Therapeutic Approach Using Dental Pulp Stromal Cells for Duchenne Muscular Dystrophy." Molecular Therapy 24 (May 2016): S93. http://dx.doi.org/10.1016/s1525-0016(16)33047-7.

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Vasandan, Anoop Babu, Shilpa Rani Shankar, Priya Prasad, Vulugundam Sowmya Jahnavi, Ramesh Ramachandra Bhonde, and Susarla Jyothi Prasanna. "Functional differences in mesenchymal stromal cells from human dental pulp and periodontal ligament." Journal of Cellular and Molecular Medicine 18, no. 2 (2014): 344–54. http://dx.doi.org/10.1111/jcmm.12192.

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Fracaro, L., E. Azevedo, A. H. D. Hochuli, et al. "DENTAL PULP STROMAL CELLS: NEUROPROTECTIVE EFFECT IN AN ANIMAL MODEL OF PARKINSON’S DISEASE." Cytotherapy 24, no. 10 (2022): S27. http://dx.doi.org/10.1016/s1465-3249(22)00908-2.

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Bozo, I. Y., V. L. Zorin, I. I. Eremin, et al. "Features of multipotent mesenchymal stromal cells derived from various intraoral sources." Genes & Cells 9, no. 4 (2014): 34–42. http://dx.doi.org/10.23868/gc120371.

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Multipotent mesenchymal stromal cells (MMSC) derived from various intraoral sources attracts attention of an increasing number of researchers due to availability and some features making them different from MMSC of bone marrow or adipose tissue. The review describes the main intraoral sources, characterizes their anatomical, topographical and histological peculiarities which may influence on MMSC morphofunctional profile. In comparative aspect we systematized the principal data concerning properties of MMSC derived from gingiva, buccal mucosa; periodontal ligament, dental pulp, apical papilla,

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Aghali, Arbi, and Huseyin E. Arman. "Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects." Regenerative Medicine 15, no. 9 (2020): 2115–27. http://dx.doi.org/10.2217/rme-2020-0061.

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Aim: This study investigated biodegradable thiol-acrylate hydrogels as stem cell carriers to facilitate cranial bone regeneration. Materials & methods: Two formulations of thiol-acrylate hydrogels (5 and 15 wt% Poly[ethylene glycol]-diacrylate [PEGDA] hydrogels) were used as stem cell carriers. Bone marrow mesenchymal stromal cells and dental pulp mesenchymal stromal cells were photoencapsulated and cultured in basal or osteogenic medium 3 days before the surgery. Using New Zealand White Rabbits, four defects (5 mm diameter and 2 mm thickness) were created and hydrogel scaffolds were impla

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Alarcón-Apablaza, Josefa, Ruth Prieto, Mariana Rojas, and Ramón Fuentes. "Potential of Oral Cavity Stem Cells for Bone Regeneration: A Scoping Review." Cells 12, no. 10 (2023): 1392. http://dx.doi.org/10.3390/cells12101392.

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Bone loss is a common problem that ranges from small defects to large defects after trauma, surgery, or congenital malformations. The oral cavity is a rich source of mesenchymal stromal cells (MSCs). Researchers have documented their isolation and studied their osteogenic potential. Therefore, the objective of this review was to analyze and compare the potential of MSCs from the oral cavity for use in bone regeneration. Methods: A scoping review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines

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Dombrovskaya, Yu A., N. I. Enukashvily, A. V. Kotova, S. S. Bilyk, A. N. Kovalenko, and A. V. Silin. "Fibrin scaffolds containing dental pulp stem cells for the repair of periodontal bone defects." Translational Medicine 7, no. 1 (2020): 59–69. http://dx.doi.org/10.18705/2311-4495-2020-7-1-59-69.

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Background. 3D scaffolds plays an important role in developing new approaches in modern dentistry. They are used to establish optimal conditions for cell differentiation, vascularization and remodeling of regenerating bone tissue.Objective. Evaluation of the possibility of creating scaffolds developed on the basis of 3D modeling of periodontal bone defects and containing tooth pulp stem cells.Materials and Methods. The computer tomography data of the maxillar bone tissue defect were analysed. Anatomical prototype — a mold representing defects of the vestibular and palatal fragments of bone tis

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Brizuela, C., George T. J. Huang, A. Diogenes, T. Botero, and M. Khoury. "The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions." Stem Cells International 2022 (September 19, 2022): 1–17. http://dx.doi.org/10.1155/2022/1580842.

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Endodontics has made significant progress in regenerative approaches in recent years, thanks to advances in biologically based procedures or regenerative endodontic therapy (RET). In recent years, our profession has witnessed a clear conceptual shift in this therapy. RET was initially based on a blood clot induced by apical bleeding without harvesting the patient’s cells or cell-free RET. Later, the RET encompassed the three principles of tissue engineering, stromal/stem cells, scaffolds, and growth factors, aiming for the regeneration of a functional dentin pulp complex. The regenerated denta

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Govindasamy, Vijayendran, Veronica Sainik Ronald, Aimi Naim Binti Abdullah, et al. "Human platelet lysate permits scale-up of dental pulp stromal cells for clinical applications." Cytotherapy 13, no. 10 (2011): 1221–33. http://dx.doi.org/10.3109/14653249.2011.602337.

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Utumi, PH, L. Fracaro, AC Senegaglia, et al. "CHARACTERIZATION OF MESENCHYMAL STROMAL CELLS DERIVED OF CANINE DENTAL PULP AND CANINE UMBILICAL CORD." Cytotherapy 23, no. 4 (2021): 7. http://dx.doi.org/10.1016/j.jcyt.2021.02.025.

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Bayarsaihan, Dashzeveg, Badam Enkhmandakh, Anushree Vijaykumar, Paul Robson, and Mina Mina. "Single-cell transcriptome analysis defines mesenchymal stromal cells in the mouse incisor dental pulp." Gene Expression Patterns 43 (March 2022): 119228. http://dx.doi.org/10.1016/j.gep.2021.119228.

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Al-Sharabi, Niyaz, Ying Xue, Masahito Fujio, et al. "Bone Marrow Stromal Cell Paracrine Factors Direct Osteo/Odontogenic Differentiation of Dental Pulp Cells." Tissue Engineering Part A 20, no. 21-22 (2014): 3063–72. http://dx.doi.org/10.1089/ten.tea.2013.0718.

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Alvarez Sanchez, Marisol. "Dental Stem Cells: classification and applications." Mexican Journal of Medical Research ICSA 11, no. 22 (2023): 30–35. http://dx.doi.org/10.29057/mjmr.v11i22.10637.

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In the last decades, the term stem cells has been one of the main topics to be discussed due to its scientific and medical importance, since its implementation in the field of medicine offers us very promising alternatives in the treatment and above all solution of diseases such as diabetes, Alzheimer, Parkinson's disease, cancer, in treatments of traumatology and orthopedics, transplants, oral surgery, as well as the reconstruction of organs and tissues including those of dental origin, among others. Stem cells are undifferentiated cells characterized by their great capacity for self-renewal,

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Hamad-Alrashid, Haifa, Sandra Muntión, Fermín Sánchez-Guijo, et al. "Bone Regeneration with Dental Pulp Stem Cells in an Experimental Model." Journal of Personalized Medicine 14, no. 11 (2024): 1075. http://dx.doi.org/10.3390/jpm14111075.

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Background/Objectives: The therapeutic approach to bone mass loss and bone’s limited self-regeneration is a major focus of research, emphasizing new biomaterials and cell therapy. Tissue bioengineering emerges as a potential alternative to conventional treatments. In this study, an experimental model of a critical bone lesion in rats was used to investigate bone regeneration by treating the defect with biomaterials Evolution® and Gen-Os® (OsteoBiol®, Turín, Italy), with or without mesenchymal stromal cells from dental pulp (DP-MSCs). Methods: Forty-six adult male Wistar rats were subjected to

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Zhang, Siyuan, Anja Lena Thiebes, Franziska Kreimendahl, et al. "Extracellular Vesicles-Loaded Fibrin Gel Supports Rapid Neovascularization for Dental Pulp Regeneration." International Journal of Molecular Sciences 21, no. 12 (2020): 4226. http://dx.doi.org/10.3390/ijms21124226.

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Rapid vascularization is required for the regeneration of dental pulp due to the spatially restricted tooth environment. Extracellular vesicles (EVs) released from mesenchymal stromal cells show potent proangiogenic effects. Since EVs suffer from rapid clearance and low accumulation in target tissues, an injectable delivery system capable of maintaining a therapeutic dose of EVs over a longer period would be desirable. We fabricated an EV-fibrin gel composite as an in situ forming delivery system. EVs were isolated from dental pulp stem cells (DPSCs). Their effects on cell proliferation and mi

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Alkhayal, Zikra, Zakia Shinwari, Ameera Gaafar, and Ayodele Alaiya. "Proteomic Profiling of the First Human Dental Pulp Mesenchymal Stem/Stromal Cells from Carbonic Anhydrase II Deficiency Osteopetrosis Patients." International Journal of Molecular Sciences 22, no. 1 (2020): 380. http://dx.doi.org/10.3390/ijms22010380.

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Osteopetrosis is a hereditary disorder characterized by sclerotic, thick, weak, and brittle bone. The biological behavior of mesenchymal cells obtained from osteopetrosis patients has not been well-studied. Isolated mesenchymal stem/stromal cells from dental pulp (DP-MSSCs) of recently extracted deciduous teeth from osteopetrosis (OP) patients and healthy controls (HCs) were compared. We evaluated whether the dental pulp of OP patients has a population of MSSCs with similar multilineage differentiation capability to DP-MSSCs of healthy subjects. Stem/progenitor cells were characterized using i

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PARANJPE, A., N. CACALANO, W. HUME, and A. JEWETT. "N-acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells." Free Radical Biology and Medicine 43, no. 10 (2007): 1394–408. http://dx.doi.org/10.1016/j.freeradbiomed.2007.07.011.

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Mazur, Svitlana, Olena Rogulska, Olena Revenko, Nataliya Volkova, and Oleksandr Petrenko. "Isolation of Human Dental Pulp Stem Cells and Their Characteristics Before and After Cryopreservation." Problems of Cryobiology and Cryomedicine 31, no. 1 (2021): 58–69. http://dx.doi.org/10.15407/cryo31.01.058.

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Dental pulp stem cells (DPSCs) from human third molar tooth germ (wisdom tooth) were isolated using a collagenasebased enzymatic method, the obtained cells were analyzed as for morphology in monolayer culture, immunophenotype, proliferation and differentiation potential before and after cryopreservation. In this study, we showed that based on morphological features, surface markers profile and differentiation potential, the isolated DPSCs corresponded to multipotent mesenchymal stromal cells. DPSCs cryopreservation by slow cooling (1 °С / min) down to –80°C with subsequent immersion into liqui

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Pivoriūnas, Augustas, Andrejus Surovas, Veronika Borutinskaitė, et al. "Proteomic Analysis of Stromal Cells Derived from the Dental Pulp of Human Exfoliated Deciduous Teeth." Stem Cells and Development 19, no. 7 (2010): 1081–93. http://dx.doi.org/10.1089/scd.2009.0315.

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Shi, S., P. G. Robey, and S. Gronthos. "Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis." Bone 29, no. 6 (2001): 532–39. http://dx.doi.org/10.1016/s8756-3282(01)00612-3.

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Gong, Qi-mei, Jing-jing Quan, Hong-wei Jiang та Jun-qi Ling. "Regulation of the Stromal Cell–derived Factor-1α–CXCR4 Axis in Human Dental Pulp Cells". Journal of Endodontics 36, № 9 (2010): 1499–503. http://dx.doi.org/10.1016/j.joen.2010.05.011.

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Marrazzo, Pasquale, Francesco Paduano, Francesca Palmieri, Massimo Marrelli, and Marco Tatullo. "Highly EfficientIn VitroReparative Behaviour of Dental Pulp Stem Cells Cultured with Standardised Platelet Lysate Supplementation." Stem Cells International 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/7230987.

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Dental pulp is an accessible source of multipotent mesenchymal stromal cells (MSCs). The perspective role of dental pulp stem cells (DPSCs) in regenerative medicine demands anin vitroexpansion andin vivodelivery which must deal with the safety issues about animal serum, usually required in cell culture practice. Human platelet lysate (PL) contains autologous growth factors and has been considered as valuable alternative to fetal bovine serum (FBS) in cell cultures. The optimum concentration to be added of such supplement is highly dependent on its preparation whose variability limits comparabi

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Hochuli, Agner H. D., Alexandra C. Senegaglia, Ana H. Selenko, Letícia Fracaro, and Paulo R. S. Brofman. "Dental Pulp from Human Exfoliated Deciduous Teeth-derived Stromal Cells Demonstrated Neuronal Potential: In Vivo and In Vitro Studies." Current Stem Cell Research & Therapy 16, no. 5 (2021): 495–506. http://dx.doi.org/10.2174/1574888x16666210215160402.

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Background: Mesenchymal Stromal Cells (MSC) have the potential for self-renewal and differentiation in different tissues, characteristics that encourage their use in regenerative medicine. Dental tissue MSCs are easy to collect, have the same embryonic origin as neurons and have neuronal markers that allow their use in treating neurodegenerative diseases. Human Exfoliated Deciduous teeth (SHED)-derived stromal cells are considered immature and present positive expression of pluripotency and neuronal markers. Studies have shown that after the induction of neuronal differentiation in vitro, SHED

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Khalid Ahmed, Al-Anazi. "Update on the Clinical Applications of Mesenchymal Stem Cells." Journal of Stem Cell Therapy and Transplantation 7, no. 1 (2023): 043–64. http://dx.doi.org/10.29328/journal.jsctt.1001034.

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Mesenchymal stem cells are heterogenous adult multipotent stromal cells that can be isolated from various sources including bone marrow, peripheral blood, umbilical cord blood, dental pulp, and adipose tissue. They have certain regenerative, anti-inflammatory, immunomodulatory, immunosuppressive, antimicrobial, and other properties that enable them to have several therapeutic and clinical applications including treatment of various autoimmune disorders; role in hematopoietic stem cell transplantation and regenerative medicine; treatment of skin, pulmonary and cardiovascular disorders; treatmen

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Williams, Laura Datko, Amanda Farley, Will McAllister, et al. "Influence of Inclusion of Apatite-based Microparticles on Osteogenic Cell Pheonotype and Behavior." MRS Advances 3, no. 40 (2018): 2409–20. http://dx.doi.org/10.1557/adv.2018.493.

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ABSTRACTThe proximity of minerals found in human hard tissues may influence cell phenotype. Since cells respond to a range of environmental cues, this study sought to identify the influence of two apatite-based microparticles, hydroxyapatite (HA) and fluoroapatite (FA), upon dental and bone cells. After bone marrow stromal cells (BMSCs), 7F2 osteoblasts and dental pulp stem cells (DPSCs) were plated into media with or without HA or FA particles, the cells were analyzed for alkaline phosphatase (ALP) production, collagen I production, osteocalcin production, and mineralization for two weeks. Th

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Merckx, Greet, Baharak Hosseinkhani, Sören Kuypers, et al. "Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles." Cells 9, no. 2 (2020): 312. http://dx.doi.org/10.3390/cells9020312.

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Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated with several drawbacks, which could be overcome by MSC-like cells of the teeth, called dental pulp stromal cells (DPSCs). This study aims to compare the angiogenic content and functions of DPSC and BM-MSC EVs and conditioned medium (CM). The angiogenic protein profile of DPSC- and B

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