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Artykuły w czasopismach na temat „Expresion 1 (1+2)”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Benedict, Barnes, O. Boateng F., K. Amponsah S., and Osei-Frimpong E. "On the Notes of Quasi-Boundary Value Method for Solving both Cauchy-Dirichlet Problem of the Helmholtz Equation." British Journal of Mathematics & Computer Science 22, no. 2 (2017): 1–10. https://doi.org/10.9734/BJMCS/2017/32727.

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The Cauchy-Dirichlet problem of the Helmholtz equation yields unstable solution, which when solved with the Quasi-Boundary Value Method (Q-BVM) for a regularization parameter = 0. At this point of regularization parameter, the solution of the Helmholtz equation with both Cauchy and Dirichlet boundary conditions is unstable when solved with the Q-BVM. Thus, the quasi-boundary value method is insufficient and inefficient for regularizing ill-posed Helmholtz equation with both Cauchy and Dirichlet boundary conditions. In this paper, we introduce an expression 1 (1+ 2) ; ∈ R, where is the regulari

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2

Rothschild, Clare K. "“Belittling” or “Undervaluing” in 2 Clem. 1:1-2?" Vigiliae Christianae 69, no. 5 (2015): 484–99. http://dx.doi.org/10.1163/15700720-12341232.

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Second Clement suffers from a lack of clarity about its historical and literary contexts. The anonymous text’s date and provenance have defied precise determination and, although it is referred to a few times in the history of tradition, it seems not to be cited at all. Moreover, its first two verses maintain a history of translation into modern languages employing expressions long out of date. The word, μικρά occurs four times in the first two verses, twice as part of the expression, μικρὰ φρονεῖν. This article identifies the outmoded nature of current translations of these words and proposes

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Radi, Zaher A., and Robert Ostroski. "Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model." Mediators of Inflammation 2007 (2007): 1–8. http://dx.doi.org/10.1155/2007/85091.

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Hypertensive mice that express the human renin and angiotensinogen genes are used as a model for human hypertension because they develop hypertension secondary to increased renin-angiotensin system activity. Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension. Male (n=15) and female (n=15) double transgenic mice (h-Ang 204/1 h-Ren 9) were used in the study. Lung, kidney, and heart tissues were obtained from mice at necropsy and fixed in 10%neutral buffered formalin followed by embeddin

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4

Fauzi, Firman Nurul, Sonia Mu'tasimatul 'Azimah, Nurul Syahrayni, and Danial Hilmi. "Arabic Expresion Teaching Model on Youtube “Muhaiban Channel”." Alsuna: Journal of Arabic and English Language 5, no. 2 (2022): 150–66. http://dx.doi.org/10.31538/alsuna.v5i2.2365.

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Purpose - The objectives of this study are: (1) to describe the learning model of Arabic expressions in Muhaiban Channel (2) to find out the content of Arabic expressions in Muhaiban Channel Design/methodology/approach - This research used a descriptive qualitative method with the type of literacy study. The method used to collect research data is in the form of books about teaching Arabic, teaching vocabulary, and selected learning media, presented and analyzed, and processed to be concise and systematic and data analysis using content analysis. Findings/result - The results of th

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5

Lin, Mei, Wenmin YUAN, Xiaohui SUN, and Zhiqiang QIN. "Expression and Significance of Beclin-1 and Bcl-2 in Gastric Cancer." International Journal of Sciences Volume 5, no. 2015-12 (2016): 58–61. https://doi.org/10.5281/zenodo.3349067.

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Objective To investigate the role and correlation of Beclin-1 and Bcl-2 in the occurrence and progression of gastric cancer. Methods The expression of Beclin-1 and Bcl-2 in 78 cases of gastric cancer, 30 cases of atypical hyperplasia and 20 cases of chronic non-atrophic gastritis was examined by immunohistochemical staining. Results The positive rate of Beclin-1 in gastric cancer was significantly lower than those in atypical hyperplasia and chronic non-atrophic gastritis(χ2=9.298,7.437, P<0.05), while there was no significant difference between atypical hyperplasia and chronic non-atrophic

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6

Amer, Radgonde, Liran Tiosano та Jacob Pe'er. "Leucine-Rich α-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma". Investigative Opthalmology & Visual Science 59, № 2 (2018): 685. http://dx.doi.org/10.1167/iovs.17-22785.

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7

Guerra, Rodríguez Lino, and Arévalo Zaida Marín. "Diagramas de tallo y hoja: cálculo de la media aritmética por el método del producto-suma." SABER 31 (April 15, 2019): 82–89. https://doi.org/10.5281/zenodo.5501666.

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<strong>RESUMEN</strong> En esta investigación bibliográfica se presenta un método denominado Producto-Suma para calcular la media de un conjunto de datos a partir de su diagrama de tallo y hoja, sin necesidad de recomponerlos a sus expresiones iniciales como se hace normalmente. Para calcular la media se crean cuatro columnas. En la primera se anotan los tallos, en la segunda, el número de hojas correspondiente a cada tallo y de ella se obtiene el número de datos. En la tercera se aplica el método del Producto-Suma para cada tallo. El Producto consist

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8

Liang, Leilei, Fuping Guan, and Yinlin Ge. "PD-1 Antitumor Immunity against Murine H22 Hepatocarcinoma In vivo." International Journal of Sciences Volume 7, no. 2018-03 (2018): 71–76. https://doi.org/10.5281/zenodo.3350253.

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Objective: To explore the role of PD-1 expression level on the growth of hepatocarcinoma line H22. Methods: Tumor-bearing mice model was established with H22 cells in ICR mice. The model mice were randomly divided into two groups, control group and PD-1 interference group (PD-1-siRNA). The control group was injected transfection reagent, wherase the PD-1-siRNA was given the transfection reagent with PD-1-siRNA. Observed the life condition and tumor growth of mice, measured and recorded the tumor volume. The mRNA expression levels of PD-L1, PD-L2, P53, caspase-3 and IL-6 in tumor tissue were de

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9

Pérez Barraza, Maria Hilda, María Alejandra Gutiérrez Espinosa, Raquel Cano Medrano, Adriana Isabel Pérez Luna, Tomás Osuna Enciso, and Irma Julieta González Acuña. "AMBIENTE Y REGULADORES DE CRECIMIENTO EN LA EXPRESION DE FLOWERING LOCUS T EN MANGO." Revista Mexicana de Ciencias Agrícolas, no. 19 (December 12, 2017): 3839. http://dx.doi.org/10.29312/remexca.v0i19.653.

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La cuantificación y expresión de genes relacionados con floración constituye una herramienta importante para entender este proceso. Trabajos realizados en Arabidopsis han servido como base para estudios moleculares en frutales. El objetivo fue cuantificar la expresión del gen FLOWERING LOCUS T (MiFT) en mango ‘Ataulfo’ y su relación con ambiente y reguladores de crecimiento. Se llevaron a cabo dos experimentos: 1) Se aplicaron árboles con 2500 mg·L-1 de paclobutrazol (PBZ) en una sola aplicación (1X) a 30 días después de la poda (ddp). Se colectaron hojas maduras de septiembre a diciembre 2013

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10

To, KF, FKL Chan, WK Leung, and JY Sung. "Expression of cyclooxygenase 1 (Cox-1) and 2 (Cox-2) in H. Pylori associated gastritis." Gastroenterology 114 (April 1998): A310. http://dx.doi.org/10.1016/s0016-5085(98)81260-2.

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11

Neu, Ricarda, Stephanie Adams, and Barbara Munz. "Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation." Differentiation 74, no. 9-10 (2006): 573–82. http://dx.doi.org/10.1111/j.1432-0436.2006.00100.x.

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12

Oelmann, Elisabeth, Harald Stein, Wolfgang E. Berdel, and Hermann Herbst. "Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma." PLOS ONE 10, no. 9 (2015): e0138747. http://dx.doi.org/10.1371/journal.pone.0138747.

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13

Tuba, Dogan, Onay Eray, and Apaydin Yildirim Betul. "Investigation of the effect of Polygonum cognatum Meissn. ethanol extract Bax, Caspase-3, Bcl-2, NF-B and NRF-2/HO-1 pathways in streptozotocin induced diabetic rats." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 203–9. https://doi.org/10.5281/zenodo.8260441.

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In this study, it was investigated of the effect of <em>Polygonum cognatum</em> Meissn. ethanol extract Bax, Bcl-2, Caspase-3, NF-kB and NRF-2/HO-1 pathways in streptozotocin induced diabetic rats. A total of 24 healthy Spraque-Dawley male rats were randomly divided into four groups containing of 6 rats per group as Control; Diabetes mellitus (DM); <em>Polygonum cognatum</em> Meissn. ethanol extract (PCE) and DM+PCE. Experimental diabetes was induced by a single dose of 60 mg/kg/i.p Streptozotocin (STZ) injection for DM and DM+PCE groups. The animals showing diabetes (Blood

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14

&NA;. "HIV-1 expression inhibited by HIV-2." Inpharma Weekly &NA;, no. 1021 (1996): 10. http://dx.doi.org/10.2165/00128413-199610210-00015.

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Brüning, J. C., J. Winnay, B. Cheatham, and C. R. Kahn. "Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells." Molecular and Cellular Biology 17, no. 3 (1997): 1513–21. http://dx.doi.org/10.1128/mcb.17.3.1513.

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Mice made insulin receptor substrate 1 (IRS-1) deficient by targeted gene knockout exhibit growth retardation and abnormal glucose metabolism due to resistance to the actions of insulin-like growth factor 1 (IGF-1) and insulin (E. Araki et al., Nature 372:186-190, 1994; H. Tamemoto et al., Nature 372:182-186, 1994). Embryonic fibroblasts and 3T3 cell lines derived from IRS-1-deficient embryos exhibit no IGF-1-stimulated IRS-1 phosphorylation or IRS-1-associated phosphatidylinositol 3-kinase (PI 3-kinase) activity but exhibit normal phosphorylation of IRS-2 and Shc and normal IRS-2-associated P

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16

Prieto-Fernández, E., L. Egia-Mendikute, L. Vila-Vecilla, et al. "Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate." Emerging Microbes & Infections 10, no. 1 (2021): 1065–76. https://doi.org/10.1080/22221751.2021.1932607.

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A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells. In Vero E6 cells, hypoxia reduces the protein levels of ACE2 and neuropilin-1 (NRP1), which might in part explain the observed reduction of the infection rate. In addition, hypoxia inhibits the binding of the spike to NCI-H460 human lung epithelial cells by decreasing the cell surface levels of heparan sulfate (HS), a known attachment receptor of SARS-CoV-2. This

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17

Donayre-Torres, Alberto J., Cristina Reynaga-Peña, and Miguel A. Gómez-Lim. "EXPRESION DE GENES QUIMÉRICOS gag DEL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH-1) EN TOMATE (Lycopersicon esculentum Mill.) Y EN Escherichia coli." Revista Fitotecnia Mexicana 31, no. 4 (2008): 309. http://dx.doi.org/10.35196/rfm.2008.4.309.

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La secuencia nativa del gen gag del virus de inmunodeficiencia humana (VIH) se expresó tanto en plantas transformadas de tomate (Lycopersicon esculentum Mill.) como en E. coli. Dos versiones quiméricas del gen gag (gag-ENV y gag-RT) se expresaron independientemente. El análisis de la expresión permitió detectar el ARNm de las construcciones en tejidos de hoja y fruto de tomate. Sin embargo, no se pudo detectar la presencia de la proteína Gag completa, aunque el anticuerpo sí detectó un dominio (p24) de Gag expresado en frutos de dos líneas transgénicas Gag-ENV. En la expresión del VIH en célul

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18

MIDOH, Naoki, and Michiaki IWATA. "Expression of Defense-related Genes by Probenazole or 1, 2-Benzisothiazole-3(2H)-one 1, 1-dioxide." Journal of Pesticide Science 22, no. 1 (1997): 45–47. http://dx.doi.org/10.1584/jpestics.22.45.

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Henckels, Eric, and Ron Prywes. "Fra-1 regulation of Matrix Metallopeptidase-1 (MMP-1) in metastatic variants of MDA-MB-231 breast cancer cells." F1000Research 2 (October 29, 2013): 229. http://dx.doi.org/10.12688/f1000research.2-229.v1.

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Matrix Metallopeptidase 1 (MMP-1) expression has repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials. We show that MMP-1 expression is regulated by an AP-1 element in its promoter in highly metastatic MDA-MB-231 mammary carcinoma cell derivatives. Fra-1, an AP-1 family transcription factor, differentially binds this element in highly metastatic cells compared to low metastatic cells and is required for MMP-1 ex

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20

Ahn, Jee Hyun, Hyun Yong Lee, Dong Hyun Kang, et al. "Programmed death-1 (PD-1) ligand 1 and PD-1 ligand 2 expressions and their clinical relevance in colorectal cancer." Korean Journal of Clinical Oncology 13, no. 2 (2017): 131–37. http://dx.doi.org/10.14216/kjco.17020.

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Kong, Hyung-Yun. "Exact BER Expression of 2-1-1 Relaying Scheme in Wireless Sensor Networks." Journal of electromagnetic engineering and science 9, no. 3 (2009): 111–17. http://dx.doi.org/10.5515/jkiees.2009.9.3.111.

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Roy, Upal, Scott A. Simpson, Debasis Mondal, Sandra Eloby-Childress, Elsa L. Winsor, and Mark A. Beilke. "Upregulation of HTLV-1 and HTLV-2 expression by HIV-1 in vitro." Journal of Medical Virology 80, no. 3 (2008): 494–500. http://dx.doi.org/10.1002/jmv.21089.

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Matsushima, K., T. Akahoshi, and J. J. Oppenheim. "Regulation of interleukin-1 (IL-1) receptor expression and protein phosphorylation induced by IL-1 stimulation." Annales de l'Institut Pasteur / Immunologie 138, no. 3 (1987): 478–81. http://dx.doi.org/10.1016/s0769-2625(87)80061-2.

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RAUK, P. "Interleukin-1 (IL-1) stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 (COX-2) expression." Journal of the Society for Gynecologic Investigation 3, no. 2 (1996): 348A. http://dx.doi.org/10.1016/1071-5576(96)83027-9.

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KACHKACHI, H., and M. KACHKACHI. "SUPERCONFORMAL STRUCTURES AND HOLOMORPHIC 1/2-SUPERDIFFERENTIALS ON N=1 SUPER RIEMANN SURFACES." Modern Physics Letters A 08, no. 38 (1993): 3643–58. http://dx.doi.org/10.1142/s0217732393002385.

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Using the super Riemann-Roch theorem we give a local expression for a holomorphic ½-superdifferential in a superconformal structure parametrized by special isothermal coordinates on an N=1 super Riemann surface. The holomorphy of these coordinates with respect to super Beltrami differentials is proved. The monodromy of these differentials is discussed.

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Abdullah, F., L. F. Neville, P. Ovadia, G. Z. Feuerstein, and R. Rabinovici. "mob-1 EXPRESSION IN IL-2-INDUCED ARDS." Shock 5 (June 1996): 56. http://dx.doi.org/10.1097/00024382-199606002-00178.

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Bradford, A. P., C. Wasylyk, B. Wasylyk, and A. Gutierrez-Hartmann. "Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression." Molecular and Cellular Biology 17, no. 3 (1997): 1065–74. http://dx.doi.org/10.1128/mcb.17.3.1065.

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The pituitary-specific, POU-homeodomain factor GHF-1/Pit-1 is necessary, but not sufficient, for cell-specific expression of prolactin (PRL), growth hormone (GH), and thyrotropin. Combinatorial interactions of GHF-1 with other factors are likely to be required; however, such factors and their mechanisms of action remain to be elucidated. Here we identify Ets-1 as a factor that functionally and physically interacts with GHF-1 to fully reconstitute proximal PRL promoter activity. In contrast, Ets-2 has no effect, and the alternatively spliced GHF-2/Pit-1beta variant fails to synergize with Ets-1

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Hoegen, Ilka Von, Werner Falk, Georgi Kojouharoff, and Peter H. Krammer. "Internalization of interleukin 1 (IL 1) correlates with IL 1-induced IL 2 receptor expression and IL 2 secretion of EL4 thymoma cells." European Journal of Immunology 19, no. 2 (1989): 329–34. http://dx.doi.org/10.1002/eji.1830190217.

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Fukuda, Y. "Expression of intercellular adhesion molecule-1 (ICAM-1), ICAM-2 and vascular cell adhesion molecule-1 (VCAM-1) in chronic active hepatitis." Hepatology 19, no. 4 (1994): I64. http://dx.doi.org/10.1016/0270-9139(94)90426-x.

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Kaeopu, Ruenruthai, Laphatrada Yurasakpong, Kulathida Chaithirayanon, et al. "Increased expression levels of cysteinyl leukotriene type 1 receptors, runt-related transcription factor 1 and matrix metalloproteinase-1 in meningiomas." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO1–8–2. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-2.

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Krecicki, Tomasz, Marcin Fraczek, Michal Jelen, Marzena Podhorska, Teresa Szkudlarek, and Tomasz Zatonski. "Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas." European Archives of Oto-Rhino-Laryngology 260, no. 9 (2003): 494–97. http://dx.doi.org/10.1007/s00405-003-0610-2.

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Mangum, Paul D., and Ellen B. Peffley. "INHERITANCE OF PGM-1, ADH-1, AND 6-PGDH-1 in ALLIUM FISTULOSUM L." HortScience 27, no. 6 (1992): 644d—644. http://dx.doi.org/10.21273/hortsci.27.6.644d.

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The inheritance and linkage relationships among PGM-1, ADH-1, and 6-PGDH-1 were determined for Allium fistulosum (Japanese bunching onion) individuals. Individuals expressing Pgm-11/Pgm-12, Adh-13/Adh-14, Adh-13/Adh-15, or 6-Pgdh-11/6-Pgdh-12 were selfed seperately. These backcrosses and their reciprocals were made: Pgm-11/Pgm-12 to Pgm-11/Pgm-11 or Pgm-12/Pgm-12; Adh-13/Adh-14 to Adh-13/Adh-13 or Adh-14/Adh-14, 6-Pgdh-11/6-Pgdh-12 to 6-Pgdh-11/6-Pgdh-11 or 6-Pgdh-12/6-Pgdh-12. Progeny segregations were tested for Mendelian inheritance using a chi-square goodness of fit test. Expression of 6-P

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Kniss, Douglas A., Peter D. Zimmerman, Cynthia L. Garver, and Richard H. Fertel. "Interleukin-1 receptor antagonist blocks interleukin-1– induced expression of cyclooxygenase-2 in endometrium." American Journal of Obstetrics and Gynecology 177, no. 3 (1997): 559–67. http://dx.doi.org/10.1016/s0002-9378(97)70146-7.

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Kucukgoz Gulec, Umran, Emine Kilic Bagir, Semra Paydas, Ahmet Baris Guzel, Derya Gumurdulu, and Mehmet Ali Vardar. "Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) expressions in type 2 endometrial cancer." Archives of Gynecology and Obstetrics 300, no. 2 (2019): 377–82. http://dx.doi.org/10.1007/s00404-019-05180-2.

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Brakman, C. M. "Evaluation of the Integral ∫−1+1 Plm,n(x)Plm−2,n(x) dx." Textures and Microstructures 7, no. 3 (1987): 207–10. http://dx.doi.org/10.1155/tsm.7.207.

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Integrals of the type indicated can be evaluated using the Fourier-series development of the Jacobi-polynomials. An alternative procedure is given yielding an analytical expression in terms of l, m and n.

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36

Ottino, Paulo, Faramarz Taheri, and Haydee E. P. Bazan. "Platelet-activating Factor Induces the Gene Expression of TIMP-1, -2, and PAI-1: Imbalance Between the Gene Expression of MMP-9 and TIMP-1 and -2." Experimental Eye Research 74, no. 3 (2002): 393–402. http://dx.doi.org/10.1006/exer.2001.1135.

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Wang, Lijun, Xuesong Hu, Wenwu Zhang, and Fang Tian. "Angiotensin (1–7) ameliorates angiotensin II-induced inflammation by inhibiting LOX-1 expression." Inflammation Research 62, no. 2 (2012): 219–28. http://dx.doi.org/10.1007/s00011-012-0571-2.

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Ohigashi, Yuichiro, Masayuki Sho, Yukishige Yamada, et al. "Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer." Clinical Cancer Research 11, no. 8 (2005): 2947–53. http://dx.doi.org/10.1158/1078-0432.ccr-04-1469.

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Nance, Christina, Melinda Mata, and Willliam Shearer. "Effect of the green tea catechin, epigallocatechin gallate, on innate immune responses in HIV-1 infection as a microbicide (P3170)." Journal of Immunology 190, no. 1_Supplement (2013): 61.10. http://dx.doi.org/10.4049/jimmunol.190.supp.61.10.

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Abstract Our preclinical data showed binding of green tea catechin, epigallocatechin gallate(EGCG), to CD4 with inhibition of HIV-1-gp120 binding to human CD4+Tcells throughout a broad spectrum of virus strains lead to implementation of our Phase I/IIa clinical trial in HIV-1-infected indivduals. As mucosal dendritic cells(DC), Langerhans cells(LC) and monoctye-derived dendritic cells(MDDC), with CD4 receptor binding to HIV-1-gp120, act as first line defense in mucosa against invading pathogens via innate immune responses,EGCG in the context of an HIV-1 microbicide was studied. Human CD34+ hem

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Kirkbride, Jason A., Garbo Young Nilsson, Jee In Kim, et al. "PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis." Biomolecules 13, no. 12 (2023): 1741. http://dx.doi.org/10.3390/biom13121741.

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Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases. Cellular Raf-1 activity is intricately regulated through pathways involving the binding of regulatory proteins, direct phosphorylation, and the ubiquitin–proteasome axis. In this study, we demonstrate that PHI-1, an endogenous inhibitor of protein phosphatase-1 (PP1), plays a pivotal role in modulating Raf-1 proteostasis within cells. Knocking down endogenous PHI-1 in HEK293 cells using siRNA res

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Xu-Monette, Zijun Y., Jianfeng Zhou, and Ken H. Young. "PD-1 expression and clinical PD-1 blockade in B-cell lymphomas." Blood 131, no. 1 (2018): 68–83. http://dx.doi.org/10.1182/blood-2017-07-740993.

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Programmed cell death protein 1 (PD-1) blockade targeting the PD-1 immune checkpoint has demonstrated unprecedented clinical efficacy in the treatment of advanced cancers including hematologic malignancies. This article reviews the landscape of PD-1/programmed death-ligand 1 (PD-L1) expression and current PD-1 blockade immunotherapy trials in B-cell lymphomas. Most notably, in relapsed/refractory classical Hodgkin lymphoma, which frequently has increased PD-1+ tumor-infiltrating T cells, 9p24.1 genetic alteration, and high PD-L1 expression, anti-PD-1 monotherapy has demonstrated remarkable obj

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Londhe, Rajkumar, and Smita Kulkarni. "HTLV-2 Encoded Antisense Protein APH-2 Suppresses HIV-1 Replication." Viruses 13, no. 8 (2021): 1432. http://dx.doi.org/10.3390/v13081432.

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Antisense protein of Human T-cell Leukemia Virus Type 2 (HTLV-2), also called APH-2, negatively regulates the HTLV-2 and helps the virus to maintain latency via scheming the transcription. Despite the remarkable occurrence of HTLV-2/HIV-1 co-infection, the role of APH-2 influencing HIV-1 replication kinetics is poorly understood and needs investigation. In this study, we investigated the plausible role of APH-2 regulating HIV-1 replication. Herein, we report that the overexpression of APH-2 not only hampered the release of HIV-1 pNL4.3 from 293T cells in a dose-dependent manner but also affect

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Yeung, Ho Y., Keng P. Lai, Hoi Y. Chan, Nai K. Mak, Graham F. Wagner, and Chris K. C. Wong. "Hypoxia-Inducible Factor-1-Mediated Activation of Stanniocalcin-1 in Human Cancer Cells." Endocrinology 146, no. 11 (2005): 4951–60. http://dx.doi.org/10.1210/en.2005-0365.

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Stanniocalcin-1 (STC1) is an endocrine hormone originally discovered in the corpuscles of Stannius, endocrine glands on kidneys of bony fishes, and also has been identified in mammals. The mammalian STC1 gene is widely expressed in various tissues and appears to be involved in diverse biological processes. There is growing evidence to suggest that altered patterns of gene expression have a role in human cancer development. Recently STC1 has been identified as a stimulator of mitochondrial respiration and has been hypothesized to be functionally related to the Warburg effect, of which hypoxia-i

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Paydas, Semra, Emine Bağır, Gulsah Seydaoglu, Vehbi Ercolak, and Melek Ergin. "Programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and EBV-encoded RNA (EBER) expression in Hodgkin lymphoma." Annals of Hematology 94, no. 9 (2015): 1545–52. http://dx.doi.org/10.1007/s00277-015-2403-2.

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Ma, Zhefu, Shannon L. Gibson, Maura A. Byrne, Junran Zhang, Morris F. White, and Leslie M. Shaw. "Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis." Molecular and Cellular Biology 26, no. 24 (2006): 9338–51. http://dx.doi.org/10.1128/mcb.01032-06.

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ABSTRACT The insulin receptor substrate (IRS) proteins are cytoplasmic adaptors that organize signaling complexes downstream of activated cell surface receptors. Here, we show that IRS-1 and IRS-2, despite significant homology, play critical yet distinct functions in breast cancer, and we identify specific signaling pathways that are influenced by IRS-1 using the polyoma virus middle-T (PyV-MT) transgenic mouse model of mammary carcinoma and Irs-1 null (Irs1 −/−) mice. The absence of Irs-1 expression enhanced metastatic spread significantly without a significant effect on primary tumor growth.

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Chou, Stella T., Charles L. Bailey, Ross C. Hardison, Gerd A. Blobel, Christopher R. Vakoc, and Mitchell J. Weiss. "GATA-1 Represses PU.1/Sfpi-1 Gene Transcription in Erythro-Megakaryocytic Progenitors." Blood 110, no. 11 (2007): 1226. http://dx.doi.org/10.1182/blood.v110.11.1226.1226.

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Abstract Commitment of multipotential hematopoietic progenitors to unique cell fates is determined by the induction and interplay of specific nuclear factors that reinforce unilineage transcriptional programs. Previously, we reported that loss of transcription factor GATA-1 promotes the expansion of bipotential megakaryocyte erythroid progenitors (MEPs) from embryonic stem cell or fetal liver derived hematopoietic progenitors. These mutant cells, termed G1ME (for Gata-1− Megakaryocyte-Erythroid), proliferate in culture and differentiate into committed megakaryocytes and erythroblasts when GATA

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Ihdina, Hanifa Hasanal Ibrahim, Putra Agung та Sumarawati Titiek. "The Effect of Hypoxic Mesenchymal Stem Cell Secretome on TNF-Α and MCP-1 Gene Expression". INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS 06, № 09 (2023): 4527–32. https://doi.org/10.5281/zenodo.8395004.

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Diabetes mellitus (DM) type 2 is a metabolic disorder with the occurrence of insulin receptor resistance and reduced ability of pancreatic β-cells to secrete insulin, there will be an increase in adipose tissue which causes hypertrophy and hyperplasia. This situation triggers inflammation involving the role of pro-inflammatory cytokines and chemokines such as TNF-α (Tumor Necrosis Factor-Alpha) and MCP-1 (Monocyte Chemotactic Protein-1). Cell-based therapies such as the administration of hypoxic mesenchymal stem cell secretom offer a new paradigm in the management of T2DM. This stud

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Llano, Manuel, Tara Kelly, Maria Vanegas, et al. "Blockade of Human Immunodeficiency Virus Type 1 Expression by Caveolin-1." Journal of Virology 76, no. 18 (2002): 9152–64. http://dx.doi.org/10.1128/jvi.76.18.9152-9164.2002.

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ABSTRACT Caveolin-1 (Cav-1) is a major protein constituent of caveolae, a type of plasma membrane raft. We observed that coexpression of human Cav-1 with human immunodeficiency virus type 1 (HIV-1) blocked virion production from cells that are ordinarily highly permissive. Further investigation showed that this effect is specific, occurs at low ratios of Cav-1 to HIV-1 DNA, depends on expression of Cav-1 protein, and involves severely impaired expression of HIV-1 proteins. Cav-1 also blocked HIV-2 expression. In contrast, Cav-1 did not inhibit protein expression by a paramyxovirus and did not

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Miki, Hiroshi, Toshimasa Yamauchi, Ryo Suzuki, et al. "Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation." Molecular and Cellular Biology 21, no. 7 (2001): 2521–32. http://dx.doi.org/10.1128/mcb.21.7.2521-2532.2001.

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ABSTRACT To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1−/−), IRS-2 deficient (IRS-2−/−), and IRS-1 IRS-2 double deficient (IRS-1−/−IRS-2−/−), from mouse embryos of the corresponding genotypes. The abilities of IRS-1−/− cells and IRS-2−/− cells to differentiate into adipocytes are approximately 60 and 15%, respectively, lower than that of wild-type cells, at day 8 after induction an

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Lee, Moo-Seung, Rama P. Cherla, Dinorah Leyva-Illades, and Vernon L. Tesh. "Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells." Infection and Immunity 77, no. 12 (2009): 5233–44. http://dx.doi.org/10.1128/iai.00665-09.

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ABSTRACT Shiga toxins (Stxs), which are proteins expressed by the enteric pathogens Shigella dysenteriae serotype 1 and some serotypes of Escherichia coli, are potent protein synthesis inhibitors. Stx-producing organisms cause bloody diarrhea with the potential to progress to acute renal failure and central nervous system complications. Studies using animal models of these diseases have shown that Stxs are major virulence factors, and purified toxins have been shown to be capable of killing many types of cells in vitro. We showed that Stx type 1 (Stx1) rapidly induced apoptosis in undifferenti

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