Gotowe bibliografie tematyczne / Hepatitis B virus and hepatitis C virus / Rozprawy doktorskie
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Rozprawy doktorskie na temat „Hepatitis B virus and hepatitis C virus”

Autor: Grafiati
Data publikacji: 2 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Bernstein, Peter Philipp. "Funktionelle Charakterisierung der Interaktion des Hepatitis-C-Virus-Core-Proteins mit der Hepatitis-B-Virus-Replikation." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975965786.

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Polis, Suzanne Public Health &amp Community Medicine Faculty of Medicine UNSW. "Hepatitis B and hepatitis C virus in an antenatal population : an epidemiological study." Awarded by:University of New South Wales. School of Public Health and Community Medicine, 2005. http://handle.unsw.edu.au/1959.4/22035.

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Although Australian epidemiology of HBV and HCV has been well described for populations groups at higher risk, but the information available for groups generally considered to be lower risk is much more limited. An understanding of the prevalence of these infections and their risk factors in antenatal women is important to guide testing policy and practice. A study was therefore conducted of the epidemiology of hepatitis B and hepatitis C infection in women. In addition, women were asked about their experience with antenatal testing. A total of 516 women participated in the survey, of these 47
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3

Sentjens, Roel Emiel Johannus Henricus. "New developments in hepatitis B, C and G virus." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87188.

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Boner, Winifred. "HBV pre-C/C variation : geographical and functional aspects." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360172.

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Yuen, Man-fung. "Role of hepatitis B virus genotypes B and C on chronic liver disease in the Chinese." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B33710089.

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Felmlee, Daniel Jeffery. "Hepatitis C virus alters lipid and lipoprotein metabolism /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 123-140). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Schüttler, Christian G. "Einfluss des Hepatitis-C-Virus-Core-Proteins auf Transkriptionselemente des Hepatitis-B-Virus ein Modell zur viralen Koinfektion /." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=96344560X.

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Negrou, Mounir. "Studies in the murine model using hepatitis B virus core as a carrier for hepatitis C virus mimotopes." Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522699.

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9

Yassin, Khaled. "Unravelling the mystery of liver diseases in Egypt : the burden of disease /." Lage : Jacobs, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009222709&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Silva, Edvaldo Ferreira da. "Prevalência de marcadores sorológicos das hepatites A e B em pacientes com hepatite C crônica atendidos no ambulatório de hepatites do serviço de Gastroenterologia Clínica do Hospital das Clínicas da Faculdade de Medicina da Universidade." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04022015-153903/.

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Introdução: Pacientes com infecção crônica pelo VHC e superinfecção pelo vírus da hepatite A (VHA) ou o vírus da hepatite B (VHB), têm maior morbi-mortalidade quando comparados com pacientes que apresentam infecção aguda somente pelo VHA ou VHB. A mortalidade associada à hepatite A aguda pode estar particularmente elevada em pacientes com pré-existência de hepatite crônica causada pelo VHC. Por esta razão, a imunização ativa com vacinas contra o VHA e o VHB vem a ser obrigatória nesta população, e consequentemente esta sorologia deve ser determinada. Objetivos: O objetivo deste trabalho foi a
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11

Taal, Maarten Willem. "Control of Hepatitis B and C virus infection in chronic haemodialysis patients." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/25675.

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Chronic haemodialysis patients have a high prevalence of Hepatitis B and C virus infections both of which are associated with chronic liver disease and hepatocellular carcinoma Hepatitis B virus (HBV) was identified as a frequent cause of hepatitis during the early years of chronic haemodialysis therapy and strict adherence to infection control measures alone proved inadequate to control the transmission of infection between patients. A policy of regular screening of all patients and blood donations for hepatitis B surface antigen together with isolation of positive patients to separate dialys
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12

Yuen, Man-fung, and 袁孟峰. "Role of hepatitis B virus genotypes B and C on chronic liver disease in the Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B33710089.

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13

Tscheuschler, Maike Karoline [Verfasser]. "Expressionsprofil ausgewählter Micro-RNAs bei Hepatitis B- und Hepatitis C-Virus assoziiertem hepatozellulären Karzinom / Maike Karoline Tscheuschler." Köln : Deutsche Zentralbibliothek für Medizin, 2011. http://d-nb.info/101293361X/34.

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14

Santos, Márcio Bezerra. "Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE." Universidade Federal de Sergipe, 2012. https://ri.ufs.br/handle/riufs/3246.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The Schistosomiasis is a parasitic disease, severe, chronic waterborne and development, whose etiologic agent is Schistosoma mansoni. It occurs in 74 countries with 207 million people infected and 700 million in risky areas. In Brazil, data indicate a prevalence of eight million. The Schistosomiasis can be exacerbated when patients are carriers of the Hepatitis B Virus (HBV) and C (HCV), resulting in simultaneous evolution of both pathologies. In Brazil, the prevalence of co-infection with HBV/HCV and S. mansoni found in studies
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15

Pacher, Bianca Messenberg. "Hepatites causadas pelos vírus B e C entre a população surda de Ribeirão Preto." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17139/tde-15082014-110519/.

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As hepatites B e C constituem ainda importante problema de saúde pública no mundo, com cifras de portadores crônicos estimados em cerca de 350 milhões e de 170 milhões, respectivamente, fazendo com que número elevado de pessoas se encontrem sob risco de cronificação e evolução para cirrose hepática e hepatocarcinoma. Entre os fatores de risco mais conhecidos para hepatite B estão às transfusões de sangue e derivados, o contato com sangue e/ou com secreções, por relações sexuais desprotegidas, compartilhamento de seringas e/ou agulhas para uso de drogas injetáveis, tatuagem e piercing com mater
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16

Mohamed, Ajayeb Dakhelallah. "The influence of HLA in chronic hepatitis B and C and analysis of a new subtype of hepatitis C virus." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243795.

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17

Wilkemeyer, Ina [Verfasser]. "Charakterisierung und Validierung von infektionsserologischen Laborparametern für den Nachweis des Humanen Immundefizienz-Virus, des Hepatitis-B-Virus und des Hepatitis-C-Virus aus postmortalem Blut / Ina Wilkemeyer." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035638711/34.

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18

Crispim, Myuki Alfaia Esashika. "Genotipagem do vírus da Hepatite C e do vírus da Hepatite Delta na Amazônia ocidental brasileira." Universidade Federal do Amazonas, 2007. http://tede.ufam.edu.br/handle/tede/3643.

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Made available in DSpace on 2015-04-22T22:14:03Z (GMT). No. of bitstreams: 1 Myuki Alfaia Esashika Crispim.pdf: 2246402 bytes, checksum: d9773c605258310c1244020f1e5cb467 (MD5) Previous issue date: 2007-09-20<br>Hepatitis B and D are endemic in the Western Brazilian Amazon region , but few studies have been conducted to investigate the genetic variability of both viruses. The hepatitis B virus (HBV) has a high genetic variability, with eight different genotypes defined (A-H). In present classification hepatitis D virus (HDV) is also supposed to present eight different genotypes (I-VIII). Th
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19

Ferreira, Ariana Carolina. "Pesquisa de marcadores sorológicos e moleculares da infecção pelo Vírus da Hepatite E (HEV) em indivíduos portadores do Vírus da Imunodeficiência Humana (HIV)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-30062016-115114/.

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A infecção pelo HEV é reconhecida como um considerável problema de saúde pública em diversas regiões do mundo. Embora caracterizada como uma infecção benigna com um curso evolutivo autolimitado, recentes estudos têm mostrado sua evolução para cronicidade em indivíduos imunocomprometidos. Além disso, tem sido verificado que nesses indivíduos a infecção crônica pelo HEV pode evoluir para fibrose hepática progressiva, culminando com o desenvolvimento de cirrose. Não existem dados acerca da prevalência da infecção pelo HEV em pacientes infectados pelo HIV no Brasil, onde a circulação deste vírus t
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20

Yao, Felix Caspar. "Investigation on the risk of viral infection in musculoskeletal grafts." University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0068.

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[Truncated abstract] Around 50,000 hip and knee replacements are performed every year in Australia and this number has been increasing by around 13% annually since 1998 (Transplantation Society 2006). The incidence and number of revision surgery has increased by a similar proportion. Autogenous bone or allograft is still the gold standard grafting material and is currently used in a variety of reconstructive surgical procedures. The use of any allograft material carries with it the risk of transfer of disease from donor to recipient. These tissues can transmit the same viral and bacterial infe
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21

Heger-Stevic, Julia Katharina [Verfasser], and Michael [Akademischer Betreuer] Nassal. "Funktionelle und strukturelle Rolle der basischen C-terminalen Nukleinsäurebindungsdomäne des Hepatitis B Virus Coreproteins." Freiburg : Universität, 2017. http://d-nb.info/118419856X/34.

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22

Arandhara, Victoria. "The role of scavenger receptor class B type I in hepatitis C virus infection." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430304.

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23

Grove, Joseph. "The role of scavenger receptor B-I in hepatitis C virus attachment and entry." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/347/.

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Hepatitis C Virus (HCV) poses a global health problem, leading to progressive disease often culminating in conditions such as hepatocellular carcinoma. HCV has a propensity to persist, with 70-80% of infected individuals failing to clear the virus. Recent evidence suggests that HCV entry is dependent on at least three cellular entry factors: CD81, Scavenger Receptor B-I (SR-BI) and Claudin-1. SR-BI is a receptor for high density lipoprotein (HDL), it is predominantly expressed in the liver and steroidogenic tissue. HCV is believed to interact with SR-BI via the viral envelope protein E2, inter
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24

Mora, Monica Viviana Alvarado. "Estudos sobre infecções pelos vírus da hepatite B (HBV), hepatite C (HCV), hepatite delta (HDV) e vírus GB-C (GBV-C) em diferentes regiões da América do Sul." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-13012012-082814/.

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As hepatites virais estão entre as mais importantes pandemias mundiais da atualidade. Existem várias causas de hepatite, entre elas, o vírus da hepatite B (HBV), o vírus da hepatite C (HCV) e o vírus da Hepatite Delta (HDV). Da mesma forma, o vírus GB-C (GBV-C) é importante na coinfecção com outros vírus, como o HIV. Nesse estudo, várias regiões da América do Sul foram analisadas. Na Colômbia, os estados do Amazonas e Magdalena foram encontradas como regiões hiperendêmicas para HBV. O genótipo F3 (75%) foi o mais prevalente. Determinou-se que o subgenótipo F3 é o mais antigo dos subgenótipos F
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25

Cheng, Xiaoming Verfasser], Ulrike [Akademischer Betreuer] [Protzer-Knolle, Markus [Akademischer Betreuer] Gerhard, and Mathias [Akademischer Betreuer] Heikenwälder. "The role of non-parenchymal liver cells in early hepatitis B virus and hepatitis C virus infection / Xiaoming Cheng. Betreuer: Ulrike Protzer. Gutachter: Markus Gerhard ; Mathias Heikenwälder." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1085024091/34.

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Pearce, Emma St Clair. "Development of antibodies and characterisation of the humoral immune responses in a surrogate animal model for hepatitis C virus (HCV)." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25978.

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Hepatitis C virus (HCV) infection has become a global public health concern with over 130 million people chronically infected and over 350,000 deaths every year from HCV-related liver diseases. GB virus-B (GBV-B) infection in tamarins is a surrogate model for acute HCV infection. Whilst HCV infection commonly leads to chronicity, GBV-B is naturally cleared. To better understand this natural clearance, this project aimed to study the associated humoral immune response to GBV-B. Additionally, GBV-B-specific antibodies were produced with the aim of characterising the pathology of the virus. Previ
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Alencar, Regiane Saraiva de Souza Melo. "Ocorrência da infecção oculta pelo vírus da hepatite B (VHB) em pacientes com cirrose hepática pelo vírus da hepatite C (VHC) com ou sem carcinoma hepatocelular (CHC)." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-16102014-103147/.

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O presente estudo avaliou materiais de 50 pacientes com cirrose hepática pelo vírus da hepatite C (VHC) que foram submetidos ao transplante hepático no Hospital das Clínicas da Faculdade de Medicina de São Paulo no período de 1993 a 2004, sendo divididos em dois grupos: Grupo 1 (33 pacientes com cirrose pelo VHC) e Grupo 2 (17 pacientes com cirrose pelo VHC com carcinoma hepatocelular). Nosso objetivo foi estudar a ocorrência da infecção oculta pelo VHB em pacientes com cirrose pelo VHC com ou sem CHC através do estudo molecular do genoma viral (DNA do VHB) no soro, tecido hepático tumoral e n
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Amin, Janaki Public Health &amp Community Medicine Faculty of Medicine UNSW. "Hepatitis B and C associated cancer and mortality: New South Wales, 1990-2002." Awarded by:University of New South Wales. School of Public Health and Community Medicine, 2006. http://handle.unsw.edu.au/1959.4/27338.

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This thesis examines cancer and mortality rates among people diagnosed with hepatitis B (HBV) and C (HCV) infection in New South Wales (NSW) from 1990 through 2002, by linking hepatitis notifications with the NSW Central Cancer Registry (CCR) and National Death Index. Of the 39101 HBV, 75834 HCV and 2604 HBV/HCV co-infection notifications included 1052, 1761 and 85 were linked to cancer notifications and 1233, 4008 and 186 were linked to death notifications respectively. Of 2072 hepatocellular carcinoma (HCC) notifications to the CCR 323, 267 and 85 were linked to HBV, HCV and HBV/HCV co-inf
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Oré, Cárdenas Andrés. "Estudio comparativo entre ultrasonografía y diagnóstico histopatológico de cirrosis y fibrosis por virus de hepatitis B y C : Hospital Edgardo Rebagliati Martins 2000-2004." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2004. https://hdl.handle.net/20.500.12672/2843.

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Se estudiaron 236 historias clínicas de pacientes atendidos en el Hospital Edgardo Rebagliati Martins, desde el año 2000 hasta julio del 2004.con fibrosis o cirrosis hepática por hepatitis viral B y C con el objetivo de evaluar el valor de diagnóstico de la ultrasonografía en comparación con el diagnóstico histopatológico. Se aplicó un sistema de puntaje ultrasonográfico a cada paciente de acuerdo a los signos US clasificándolos en una escala de 4-11. Se transcribieron los puntajes histopatológicos según el sistema METAVIR y se evaluó la sensibilidad, especificidad, valor predictivo positivo y
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30

Asplid, Matilda, Ponce Gabriela Becerra, and Ponce Paula Becerra. "Att leva med en smittsam blodsjukdom." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-38648.

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Humant immunbristvirus (HIV), hepatit B och C är blodsmittor som finns världen över. Dessa tre sjukdomar anses som allmänfarliga och som anmälningspliktiga sjukdomar. Livet med en smittsam blodsjukdom kan vara påfrestande för en patient, både fysiskt och psykiskt. Syftet med denna litteraturstudie var att beskriva patienters upplevelse av att leva med en smittsam blodsjukdom. Studien är en allmän litteraturstudie, där kvalitativ forskning användes för att få fram resultatet. Resultatet består av tre teman och sju subteman. De teman som skapades var: rädsla, känslan av att vara osedd och känsla
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Ramière, Christophe. "Interactions entre le métabolisme hépatique des sels biliaires et des lipoprotéines et les infections par les virus des hépatites B et C." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10016.

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Les virus des hépatites B et C (VHB et VHC) entretiennent des liens étroits avec le métabolisme lipidique des hépatocytes. Ainsi, la réplication du VHB est dépendante de certains récepteurs nucléaires hépatiques, tels que HNF4α et PPARα, impliqués dans ce métabolisme. L’assemblage des particules virales du VHC dépend lui de la voie de synthèse des lipoprotéines de très faible densité (VLDL) et le virus circule dans le sang sous forme de lipo-viro-particules associé notamment à l’apolipoprotéine B, un composant essentiel des VLDL. Dans ce travail, nous avons d’abord étudié le rôle de FXRα, le r
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Bwanali, Jessica Atupele. "Identification of hepatitis C virus E2 glycoprotein binding determinants on human scavenger receptor class B type 1." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537621.

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Wilhelm, Frank [Verfasser]. "Prävalenzen und Risikofaktoren für Hepatitis-B- und -C-Virus-Infektionen bei HAART-naiven HIV-Patienten / Frank Wilhelm." Köln : Deutsche Zentralbibliothek für Medizin, 2013. http://d-nb.info/1036140105/34.

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Oliveira, Cintia Mara Costa de. "Análise molecular e implicações biológicas do vírus da Hepatite B, em pacientes naturais do estado do Amazonas." Universidade Federal do Amazonas, 2007. http://tede.ufam.edu.br/handle/tede/3091.

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Made available in DSpace on 2015-04-20T12:31:31Z (GMT). No. of bitstreams: 1 Cintia Mara Costa de Oliveira.pdf: 1536626 bytes, checksum: a546517f7c00e6b13c3a43eac85bbc3f (MD5) Previous issue date: 2007-06-01<br>Fundação de Amparo à Pesquisa do Estado do Amazonas<br>The hepatitis B virus (HBV) is an agent of universal distribution which produces in humanity both the gaud and chronic infection. According to the World health organization (WHO) approximately 30% of world population, or about 2 billion of the people, are infected by the HBV. Of these, more than 350, million have become chronic
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Barcos, Iara Pinheiro [UNESP]. "Análise da prevalência e de fatores de risco para as hepatites virais crônicas B e C em idosos residentes no município de Botucatu-SP." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108650.

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Made available in DSpace on 2014-08-13T14:50:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-08-19Bitstream added on 2014-08-13T18:00:23Z : No. of bitstreams: 1 000760134.pdf: 1725206 bytes, checksum: 222454d9746b364842305efbfe5f9a10 (MD5)<br>A Organização Mundial de Saúde (OMS) define como idoso todo indivíduo com mais de 60 anos de idade. Atualmente no Brasil os idosos são aproximadamente 15 milhões de pessoas e apesar de viverem mais, apresentam maiores condições crônicas devido ao declínio da maioria das funções orgânicas, inclusive do sistema imunológico, aumentando a suscepti
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Bach, Guillaume. "Identification d'espèces moléculaires de lysophosphatidylcholine présentant des activités adjuvantes en vue d'un développement clinique." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00583087.

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La découverte d'adjuvants de vaccination est en pleine expansion dans un contexte règlementaire de plus en plus strict. L'objectif de ce travail de thèse a été de proposer un adjuvant hautement caractérisé de la famille de la lysophosphatidylcholine (LPC) pour un développement clinique. Il avait été précédemment montré que la LPC d'oeuf de poule présentait des propriétés adjuvantes in vitro et in Vivo. Cependant, il s'agit d'un mélange hétérogène d'espèces moléculaires de LPC peu exploitable en clinique. Nous avons donc cherché à 1/ cribler in vitro 5 différentes espèces moléculaires de LPC ay
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Rodriguez, Christophe. "Dynamique adaptative des virus hautement variables à un nouvel environnement réplicatif." Phd thesis, Université Paris-Est, 2012. http://tel.archives-ouvertes.fr/tel-00916824.

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La lutte pour les ressources est un phénomène qui a débuté dès l'apparition d'organismes reproductifs et dont la description a été initiée par Malthus puis remarquablement synthétisée et étendue à la biologie sous le terme d'évolution par Darwin en 1859 dans " De l'origine des espèces ". Si le concept est ancien à l'échelle des sciences biologiques, il continue à caractériser des domaines à l'époque insoupçonnés par son auteur tels que la virologie. En effet, les virus hautement variables tels que le virus de l'immunodéficience humaine (VIH), de l'hépatite B (VHB) et de l'hépatite C (VHC) sont
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Kühne, Claudia [Verfasser], and Stefan [Akademischer Betreuer] Lüth. "Einfluss des Hormons Vitamin D3 auf die Hepatitis B sowie Einfluss pflanzlicher Limonoide und Phytosterole auf die Hepatitis-C-Virus-Replikation im Zellkulturmodell / Claudia Kühne ; Betreuer: Stefan Lüth." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2017. http://d-nb.info/1138359939/34.

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Masembe, Melissa. "The effectiveness of the Stockholm needle exchange programme : Does the Stockholm needle exchange programme control HIV, Hepatitis B, and Hepatitis C in intravenous drug users?" Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-38802.

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BACKGROUND: The needle exchange programme (NEP) started in Sweden in 1986 in Lund and shortly after in Malmo. The first NEP in Stockholm opened in spring 2013. The NEP is a service aimed at intravenous drug users (IDU) from 18 years old, with a goal of preventing the blood borne diseases, such as HIV, Hepatitis B (HBV), and Hepatitis C (HCV). With the on going HIV and Hepatitis epidemics, numerous countries around the world have adopted control strategies, such as the NEP to halt the spread of HIV, HBV, and HCV. The objective of this study was to examine if the needle exchange programme has de
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Stander, Melissa. "Assisted reproduction services : accessible screening and semen profiling of HIV-positive males." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40837.

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Introduction International guidelines endorse the screening of patients for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Chlamydia trachomatis before assisted reproductive techniques (ART). At present no such guidelines exists in South Africa. At the Reproductive and Endocrine Unit (referred to as “the Unit”) of Steve Biko Academic Hospital, all patients with unknown HIV status are counselled and a blood sample is collected during the initial visit for automated laboratory based HIV screening. These HIV results are not available before semen samp
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CATANESE, MARIA TERESA. "Scavenger receptor class B type 1 is an essential receptor for Hepatitis C virus and a potential target for novel therapies." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/409.

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L’epatite C costituisce un problema sanitario di importanza globale e si stima che circa il 3% della popolazione mondiale sviluppi epatite C cronica (circa 170 milioni di persone). Un vaccino per l’epatite C non e’ ancora disponibile e le attuali terapie hanno un’efficacia limitata, costi elevati e effetti collaterali notevoli. Vi e’ pertanto un urgente bisogno di sviluppare nuove terapie che agiscano attraverso differenti meccanismi d’azione. Recenti scoperte nel campo della biologia di HCV hanno portato ad una migliore comprensione dei meccanismi molecolari di legame e ingresso del virus n
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Swann, Rachael Elizabeth. "Characterising the B-cell response to Hepatitis C virus infection in patient cohorts : impact on clinical outcomes and implications for vaccine design." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8797/.

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Hepatitis C virus (HCV) infection is one of the major causes of liver morbidity and mortality worldwide. While effective therapies are now available, if eradication of this virus is to be achieved globally, an effective vaccine is still necessary. During hepatitis C virus (HCV) infection, broadly neutralizing antibody (bNAb) responses targeting E1E2 envelope glycoproteins are generated in many individuals. It is unclear if these antibodies play a protective or a pathogenic role during chronic infection or if they could prevent infection or reinfection with the virus. I investigated the presenc
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Comarmond, Chloé. "Rupture de la tolérance immunitaire au cours des vascularites cryoglobulinémiques associées au virus de l'hépatite C." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066469.

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Les vascularites cryoglobulinémiques associées au virus de l'hépatite C (VC-VHC) sont caractérisées par une expansion clonale de lymphocytes B mémoires anergiques CD27+IgM+CD21-/low (Bm21-), un défaut quantitatif en lymphocytes T régulateurs (Tregs) et une polarisation Th1. Les antiviraux d'action directe sans interferon (DAAs) sont très efficaces chez les patients VC-VHC mais leur mécanisme d'action sur l'immunité cellulaire reste inconnu. Nous montrons que les DAAs normalisent la plupart des perturbations de l'homéostasie lymphocytaire B et T, en diminuant l'expansion des Bm21- et T follicul
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Zarski, Jean-Pierre. "Virus de l'hépatite B : mise en évidence du génome viral et étude des mutations pré-C." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10217.

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Ce travail rapporte dans sa premiere partie, l'interet de la detection de l'adn du virus de l'hepatite b (vhb) dans le serum, par differentes methodes permettant une quantification de la viremie. Apres avoir mis au point une technique d'hybridation en phase liquide avec marquage a l'iode 131, l'auteur montre son interet dans le suivi des malades sous traitement antiviral. La technique de pcr est plus sensible et permet dans certains cas de differencier les vrais des faux-positifs. La technique d'hybride capture avec revelation en chemiluminescence, a une sensibilite equivalente et est plus fac
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Loras, Alastruey Carme. "Prevalença de la infecció pel virus de la hepatitis B i C en pacients amb malaltia inflamatòria intestinal. Impacte del tractament immunosupressor en l’evolució de l’hepatopatia." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/32015.

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INTRODUCCIÓ: Hi ha molt poca informació a la literatura mèdica que suggereix que existeix una alta prevalença de la infecció pel virus hepatitis B (VHB) i C (VHC) en malalts amb malaltia inflamatòria intestinal (MII). El seu coneixement és important per la possibilitat de reactivació viral relacionada amb el tractament immunosupressor. HIPÒTESI: La infecció per VHB i C és més freqüent en la MII que en la població general de referència. El tractament immunosupressor pot reactivar la infecció per VHB i C. OBJECTIUS: Avaluar: 1) La prevalença d'infecció per VHB i C en pacients amb MII de diferent
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Krassnitzky, Olaf. "Mapping disasters, the application of a disaster-sociological theoretical superstructure and methodology in a prima facie case for investigating the role of hepatitis B vaccines in the contamination of the Canadian blood supply with human immunodeficiency (AIDS) virus (HIV) and hepatitis C virus (HCV)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ52326.pdf.

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Krassnitzky, Olaf Carleton University Dissertation Sociology and Anthropology. "Mapping disasters; the application of a disaster-sociological 'Theoretical superstructure' and methodology in a Prima Facie case for investigating the role of hepatitis B vaccines in the contamination of the Canadian blood supply with human immunodeficiency (AIDS) virus (HIV) and hepatitis C virus (HCV)." Ottawa, 2000.

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Jammart, Baptiste. "Étude in vitro de l'association du virus de l'hépatite C avec les lipoprotéines de l'hôte." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10082/document.

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Le virus de l’hépatite C (HCV) infecte les hépatocytes. Il est remarquable par le fait q’ilperturbe fortement le metabolisme lipidique de l’hôte, conduisant à des dysfonctions majeures telles qu’une stéatose ou une résistance à l’insuline. In vivo, les virions sériques présentent une densité faible et variable reflétant leur association aux lipoprotéines de faible et de tres faible densité (LDL et VLDL). Ainsi, l'existence de lipo-viro-particules (LVP), contenant à la fois les constituants viraux et les apolipoprotéines B (apoB) et E (apoE) a été suggerée. Ces LVP joueraient un rôle important
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Callaghan, Maximilian W. "Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9404.

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Recombinant hepatitis B virus (HBV) core particles have been successfully used as particulate carriers exposing viral and bacterial antigens on their surface. The objective of this research was to explore the use of recombinant core particles from HBV and its close relative the woodchuck hepatitis virus for edible vaccine technology. This was accomplished in two parts. Part 1 was the transformation of a truncated HBV core protein gene into transgenic tobacco plants and characterization of the gene's expression with respect to mRNA levels, protein levels, and particle self-assembly. Part 2 was
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Walker, Christine [Verfasser], and C. Th [Akademischer Betreuer] Bock. "Therapie der chronischen Hepatitis B Virus Infektion : Geno- und phänotypische Analyse der Selektion von Resistenzmutationen unter antiviraler Therapie mit Nukleos/tidanaloga / Christine Walker ; Betreuer: C.-Th. Bock." Tübingen : Universitätsbibliothek Tübingen, 2011. http://d-nb.info/1161464573/34.

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