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Rozprawy doktorskie na temat „In Vitro Cytotoxicity Test”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Srikanth, Madhulika. "In vitro cytotoxicity tests of nanomaterials on 3T3 and l929 cancerous cells." Thesis, Wichita State University, 2012. http://hdl.handle.net/10057/5422.

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In this MS thesis, cytotoxicity tests of various nanomaterials, which have commercial applications and involve a contact with human body, were performed at different conditions. The nanomaterials used for the experiments included pristine 100 ply carbon nanowire, graphene nanoflakes, multiwall carbon nanotubes, nanoclay and C60 (buckyball or fullerene). The nanomaterials cytotoxicities were calculated and compared to each other using human and mice fibroblast cancerous cells (3T3 and L929 resp.). The in vitro MTT Assay was used as the testing method because of its simplicity and reliability. T

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Cruz, Aurea Silveira. "Teste de citotoxicidade \'in vitro\' como alternativa ao teste \'in vivo\' de Draize na avaliação de produtos cosméticos." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-03082007-170357/.

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Os procedimentos descritos por Draize são a base dos testes de irritação ocular e cutânea adotados internacionalmente para avaliar produtos e substâncias. Entretanto, eles têm sido criticados por motivos éticos, devido à crueldade com os animais e, por isso, metodologias alternativas têm sido estudas para avaliar a toxicidade de produtos que entram em contato com o ser humano. Sendo assim, um estudo comparativo foi realizado entre testes de irritação ocular, cutânea e mucosa oral usando coelhos e testes in vitro pelos métodos de difusão em ágar e de captura do vermelho neutro, ambos usando as

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Azevedo, Janice Campos de. "Avaliação de metodologia alternativa in vitro ao teste de irritação ocular de Draize." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-25102011-100819/.

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Para a avaliação do potencial irritante de substâncias aplicadas topicamente tem-se utilizado metodologias que baseiam nos estudos de Draize, onde preconiza-se o uso de animais. Devido à forte oposição a estes testes, intensa tem sido a busca por métodos alternativos visando diminuir ou eliminar a utilização de animais. Este estudo avaliou o potencial irritante de diversas substâncias através de duas metodologias: o teste in vivo , empregando metodologia oficial do Food and Drug Administration (FDA), onde utiliza-se coelhos e o teste de citotoxicidade in vitro - método de difusão em camada de

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Amaral, Mauricio Bordini do. "Citotoxidade in vitro e biocompatibilidade in vivo de compósitos a base de hidroxiapatita, colágeno e quitosana." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-30072007-163145/.

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Na engenharia de tecidos os biomateriais são usados tanto para induzir a formação óssea no tecido adjacente quanto agir como matriz temporária de células e outros agentes. Compósitos biodegradáveis a base de hidroxiapatita, colágeno e quitosana foram preparados como arcabouços para permitir a regeneração óssea. Este estudo teve como objetivo avaliar a toxicidade celular in vitro de novos compósitos de substituição óssea e o seu comportamento biológico após implantação subcutânea no processo de remodelação e cicatrização tecidual. Foram confeccionadas mantas a base de hidroxiapatita (HA), obtid

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Manuel, Nathalie. "Etude "in vitro" de la libération des sérine-estérases par des cellules effectrices cytotoxiques humaines au moyen d'un test enzymatique." Paris 5, 1993. http://www.theses.fr/1993PA05P042.

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Bonatto, Liliane da Rocha [UNESP]. "Biocompatibilidade de primers e adesivo utilizados na confecção de próteses maxilofaciais implantorretidas: análise in vitro." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/134194.

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Made available in DSpace on 2016-02-05T18:30:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-15. Added 1 bitstream(s) on 2016-02-05T18:34:15Z : No. of bitstreams: 1 000857711.pdf: 1685122 bytes, checksum: 06044cf174850099dc014984d0007cc8 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A prótese bucomaxilofacial implantorretida pode ser suportada por pele ou por mucosa. Subprodutos dos materiais utilizados na confecção destas próteses podem atuar como irritantes ou causadores de reações alérgicas a tais tecidos. A proposta do presente estudo foi av

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Bonatto, Liliane da Rocha. "Biocompatibilidade de primers e adesivo utilizados na confecção de próteses maxilofaciais implantorretidas : análise in vitro /." Araçatuba, 2015. http://hdl.handle.net/11449/134194.

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Orientadora: Daniela Micheline dos Santos<br>Coorientador: Marcelo Coelho Goiato<br>Banca: Marcela Fillié Haddad<br>Banca: Sandra Helena Penha de Oliveira<br>Resumo: A prótese bucomaxilofacial implantorretida pode ser suportada por pele ou por mucosa. Subprodutos dos materiais utilizados na confecção destas próteses podem atuar como irritantes ou causadores de reações alérgicas a tais tecidos. A proposta do presente estudo foi avaliar a citotoxicidade de primers e adesivo utilizados na confecção de próteses maxilofaciais retidas por implantes, por meio da análise da proliferação celular e da p

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Roux, Hélène. "Optimisation d'un test in vitro de la cytocompatibilité des biomatériaux en culture organotypique." Compiègne, 1993. http://www.theses.fr/1993COMPD567.

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L'essor des biomatériaux et leur utilisation dans le domaine médical ainsi que le développement des méthodes alternatives aux tests in vivo sont à l’origine des techniques permettant de mesurer la cytocompatibilité et la cytotoxicité des matériaux. Un modèle base sur la culture organotypique, permet d'évaluer la cytocompatibilité et la cytotoxicité des matériaux au contact des tissus. Il repose sur la mesure de trois propriétés : la multiplication cellulaire, la migration cellulaire et l'adhésion des cellules au substrat. Ce travail a eu pour objet l'optimisation et la validation du modèle. L'

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Figarol, Agathe. "Toxicité in vitro et propriétés physico-chimiques de nanotubes de carbone." Thesis, Saint-Etienne, EMSE, 2014. http://www.theses.fr/2014EMSE0764/document.

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Les propriétés exceptionnelles des nanotubes de carbone (CNT) attirent de nombreux industriels dans les domaines de la microélectronique, des matériaux ou de la nanomédecine. Néanmoins, le risque sanitaire lié à ce nanomatériau reste encore mal compris. Des profils toxicologiques différents, dépendant des caractéristiques physico-Chimiques des CNT, ont été mis en évidence. Une approche « safer by design » est proposée, afin d’identifier les paramètres pouvant, dès la conception des CNT, pour limiter le risque sanitaire. Dans ce contexte, cette thèse avait pour objectif d’étudier l’impact sur l

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Mazurek, Nicole. "Untersuchungen zur Genexpression und Differenzierung muriner embryonaler Stammzellen in vitro zur Prädiktion eines embryotoxischen Potentials ausgewählter Chemikalien." Master's thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2013/6891/.

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Der Embryonale Stammzelltest (EST) ist ein validierter In-vitro-Embryotoxizitätstest, der zur Untersuchung embryotoxischer Wirkungen von Chemikalien eingesetzt werden kann. Während des zehntägigen Differenzierungsassays differenzieren sich die pluripotenten murinen embryonalen Stammzellen (ES-Zellen) der Linie D3 in vitro in spontan kontrahierende Herzmuskelzellen. Dabei rekapitulieren sie Prozesse der frühen Embryogenese in vivo. Ein Zytotoxizitätsassay mit D3-Zellen und ausdifferenzierten, adulten 3T3-Maus-Fibroblasten dient der Ermittlung allgemeiner zytotoxischer Effekte und unterschiedlic

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Akasov, Roman. "Novel 3D in vitro models based on multicellular tumor spheroids to test anticancer drugs and drug delivery vehicles." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF013/document.

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Les sphéroïdes multicellulaires tumoraux (SMT) constituent un outil prometteur dans le domaine de l’étude biologique des tumeurs. Le but de la thèse était de développer une technique de la formation de SMT et de démontrer la disponibilité de ces sphéroïdes comme modèle in vitro 3D pour tester l’efficacité de principes actifs anticancéreux ainsi que celle de formulations de délivrance de médicaments. L'effet d’auto-assemblage de cellules induit par une addition des peptides RGD cycliques a été étudié pour 16 lignées cellulaires de différentes origines. Le peptide cyclique RGDfK et sa modificati

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Sultana, Sadequa. "Study of Toxicity of Nanoparticles in Biological Media." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCD018/document.

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Gold nanoparticules (GNPs) are of great interest for several applications in nanomedicine ; espacially in imaging and sensing, drug delivery or photothermal therapy because of their unique physical and chemical properties. For all theses applications, a better understanding of the interaction of GNPs with biomolecules and their uptake into cells is of great importance. Thus the main objective of this thesis was to study the toxicity of GNPs in biological media based on their sizes, shapes and surface chemistries. Cytotoxicity studies on human cells were done in vitro in presence of six GNP sam

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Madiedo-Podvršan, Sabrina. "Development of a lung-liver in vitro coculture model for the risk assessment of inhaled xenobiotics." Electronic Thesis or Diss., Compiègne, 2022. http://www.theses.fr/2022COMP2703.

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L’urbanisation et la mondialisation sont des phénomènes de société qui multiplient et complexifient les sources de pollution. Parmi elles, la pollution atmosphérique impacte notablement la santé humaine à l’échelle mondiale de par son caractère transfrontière. L’appareil respiratoire est une voie d’absorption de nombreux xénobiotiques, sous forme de gaz, d’aérosols ou de nanoparticules. Une fois dans les voies respiratoires, les substances inhalées sont susceptibles d’interagir avec les cellules pulmonaires. Les mécanismes par lesquels des xénobiotiques inhalés induisent des dommages pulmonair

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Derache, Philippe. "Influence de la reduction des xenobiotiques organo-nitres sur la peroxydation des phospholipides." Toulouse 3, 1986. http://www.theses.fr/1986TOU30062.

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Introduction aux problemes de la peroxydation radicalaire des lipides, notamment au travers de la toxicite de l'oxygene. Effets des composes organonitres sur cette toxicite (etudes in vivo, in vitro, etudes de la mutagenicite)

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So, Mei-yu, and 蘇美如. "In vitro and in vivo cytotoxicity of zearalenone." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196014.

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Zearalenone (ZEA), a mycoestrogen produced by Fusarium fungal species, is mainly found in contaminated corns and maize. Despite ZEA has been reported in air and waters, little is known about the toxic effects induced by ZEA in vitro or in vivo. As ZEA has a similar structure to estrogen, its potential risk as an endocrine disrupting chemical (EDC) has thus aroused both environmental and public health concerns. The purpose of the first part of the study is to identify the responses and underlying molecular changes that occur when human bronchial epithelial BEAS-2B cells are exposed to ZEA. Dif

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Chan, Yiu-ming. "The chemistry and in vitro cytotoxicity study of manganese oxide nanostructures." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557121.

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Chan, Yiu-ming, and 陳耀明. "The chemistry and in vitro cytotoxicity study of manganese oxide nanostructures." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557121.

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Horner, S. A. "An investigation of the metabolism-mediated cytotoxicity of xenobiotics in vitro." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374318.

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Smith, Lesley Mary. "Evaluation of an in vitro cytotoxicity assay for specific groups of chemicals." Thesis, University of Nottingham, 1991. http://eprints.nottingham.ac.uk/11910/.

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The FRAME KB cytotoxicity assay is an ill vitro test for basal cytotoxicity which measures the sub-lethal inhibition of cell growth by toxic substances. Exponentially growing 3T3-Ll mouse fibroblasts are exposed to a range of concentrations of a test substance for 72 hours, then relative cell number is estimated by the protein/kenacid blue dye-binding method. The assay was evaluated for its ability to predict parameters of in vivo acute lethal potency. In vivo/in vitro comparisons were performed for a set of miscellaneous chemicals and for a set of metal compounds. The degree of correlation wa

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Jarrett, John M. "Synthesis and In-Vitro Cell Viability/Cytotoxicity Studies of Novel Pyrrolobenzodiazepine Derivatives." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/honors/361.

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Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the d

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Thom, David Charles. "The hemolysis and cytotoxicity of a zeolite-containing root filling material in vitro." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63009.pdf.

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Correia, Catarina Ribeiro. "Evaluation of pathogenic potential of Aeromonas spp. strains using in vitro methodologies." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10988.

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Dissertation to obtain a Master Degree in Molecular Genetics and Biomedicine<br>Aims: To contribute to the evaluation of the pathogenic potential of Aeromonas, through the test of 24 Aeromonas spp. strains of Portuguese origin, for the adherence, invasion and cytotoxicity abilities in mammal cells. Rationale: Studies on other enteropathogens indicate that a pathogen must be able to attach to host target cells to cause gastrointestinal disease [Finlay and Falkow, 1997; Scoglio et al., 2001], via either toxin production or host cell invasion, or both [Knutton, et al. 1987]. Results: 19 (79%

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Müller, Stephan. "Surface functionalized dendrimers with potential application for anticancer therapy synthesis and in vitro cytotoxicity /." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/242/index.html.

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Moret, Francesca. "Nanovehicles for medical use: an in vitro evaluation of cytotoxicity and drug delivery efficiency." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423637.

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The recent progresses offered by nanotechnology in the manipulation of matter lead to the development of several nanoparticles (NPs) and nanodevices for medical applications. In oncology, nanosized objects are particularly attractive as drug delivery systems since it is expected that engineered nanovehicles of appropriate size and functionalised with specific ligands/antibodies will improve the efficacy and selectivity of cancer therapies by exploiting both the passive and active mechanism of tumour targeting. The use of delivery systems is particularly appealing in those therapies in which th

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Ayres, Reuben Christopher Simon. "In vitro investigation into the role of human intrahepatic biliary epithelial cells as targets in primary biliary cirrhosis." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296245.

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Lessa, Fernanda Campos. "Citotoxicidade direta e transdentinária da clorexidina sobre células odontoblastóides MDPC-23 e análise de sua atividade antimicrobiana in vitro /." Araraquara : [s.n.], 2008. http://hdl.handle.net/11449/104257.

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Orientador: Carlos Alberto de Souza Costa<br>Banca: Elisa Maria Aparecida Giro<br>Banca: Denise Madalena Palomari Spolidorio<br>Banca: Maria Cristina Borsatto<br>Banca: Mario Fernando de Góes<br>Resumo: O objetivo da presente pesquisa foi avaliar o efeito citotóxico direto e transdentinário de diferentes concentrações de clorexidina (CHX), bem como sua atividade antibacteriana. Para isto, concentrações de 0,06%; 0,12%; 0,2%; 1% e 2% de CHX foram aplicadas sobre células odontoblastóides MDPC-23 em cultura (teste direto). Além disto, as concentrações de CHX também foram aplicadas sobre a superfí

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Manglik, Aparna Safety Science Faculty of Science UNSW. "Development of comparitive methods for chemical analysis and in vitro cytotoxicity testing of contaminated sites." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/25168.

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This project developed methodology for in vitro toxicity assessment of contaminated sites using the Promega?? MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy-methoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay performed on human cells (HepG2 and Skin fibroblasts). The project included the development of a method for extracting contaminants from soil based on leaching and centrifugation. A number of solvents and surfactants were assessed for their suitability as extracting agents. The Zwitterionic surfactant CHAPS ({3[(3-Cholamidopropyl) dimethylammonio] propanesulphonic acid}), which is an i

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Gomes, Juliana Pizarro Martins. "Pesquisa de atividade antitumoral e mutagênica in vitro de produtos naturais /." Araraquara : [s.n.], 2008. http://hdl.handle.net/11449/97908.

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Resumo: O presente trabalho avaliou a citotoxicidade in vitro de produtos naturais (terpenos, iridóides e derivados fenólicos) em linhagens celulares de adenocarcinoma murino de mama (LM3) e de pulmão (LP07), buscando uma possível correlação entre estrutura molecular e atividade antitumoral. A ordem de citotoxicidade na linhagem LM3 foi tingenona> pristimerina> plumericina> cromeno> paclitaxel> escandenina> acetato de bauerenila> ácido p-cumárico> ácido clorogênico. Na linhagem LP07, a exceção é a inversão de posição entre os ácidos clorogênico e p-cumárico e escandenina e paclitaxel. Pristime

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Ferron, Pierre-Jean. "Nouvelles approches in vitro pour l'étude des phycotoxines lipophiles seules ou combinées." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S023.

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Certaines espèces de phytoplanctons produisent des métabolites secondaires hautement toxiques appelés phycotoxines. Ces phycotoxines peuvent contaminer les fruits et mer et poser un risque sanitaire pour l'homme. Elles sont responsables d'effets néfastes chez l'homme et peuvent provoquer des diarrhées, des nausées et des douleurs abdominales. Pour améliorer l'évaluation du risque sanitaire lié à la présence de phycotoxines dans les coquillages, une meilleure caractérisation du potentiel toxique est indispensable. Aussi, l'objectif de ce doctorat a été d'étudier les effets cytotoxiques des phyc

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Mazzotti, Francesca. "In vitro rodent models as alternative methods in assessing cytotoxicity and carcinogenic potential of metal compounds." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/3866.

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Los ensayos in vitro de transformación celular abarcan el proceso multifásico que va desde la conversión neoplásica hasta el establecimiento del fenotipo tumorigénico. En la presente tesis doctoral, el ensayo in vitro Balb/3T3, con una línea celular inmortalizada de fibroblastos de ratón, ha sido aplicado para determinar la citotoxicidad y el potencial carcinogénico de una serie de compuestos metálicos seleccionados por su interés ambiental, laboral y biomédico, adoptando una estrategia específica de trabajo en varias etapas. Esto ha implicado una optimización muy precisa del protocolo para d

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Flageole, Hélène. "Substance P increases in vitro lymphokine-activated-killer (LAK) cell cytotoxicity against fresh colorectal cancer cells." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56993.

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Gut associated lymphoid cells are modulated by gut hormones. We postulated that lymphokine-associated-killer (LAK) cell cytotoxicity of lymphocytes from the gut mucosa may be increased by substance P (SP).<br>Intestinal lamina propria mononuclear cells (LPMC) and colonic cancer cells were isolated from operative specimens by mechanical and enzymatic dissociation methods. Effector LAK cells were induced by culturing LPMC with 250 u/ml of recombinant interleukin-2 (IL-2). Substance P (10$ sp{-5}$M) was added to the culture. Targets consisted of fresh colon cancer cells, HT-29 and control cell li

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Partridge, M. B. "A study of the in vitro cytotoxicity of alkylaminoathraquinone antitumour agents based on doxorubicin and mitozantrone." Thesis, De Montfort University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378925.

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Ekpo, Okobi Eko. "The in vitro and in vivo anti-flammatory properties and cytotoxicity of extracts of Euphorbia hirta." Thesis, University of Pretoria, 2008. http://hdl.handle.net/2263/30817.

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Asthma is considered one of the most common respiratory complaints in the world today but a medical cure for this condition is currently not available. The use of herbal medicines to treat asthma has however been reported and Euphorbia hirtais one such herb. The alkaloids, flavonoids, glycosides, sterols, tannins and triterpenoids in E. hirta appear to exert the anti-asthma effects reported. In the first part of this study, the aqueous, acetone, dichloromethane and hexane extracts of E. hirta were evaluated for their effects on the lysosomal membrane integrity, cell viability and cell number o

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Tate, Matthew. "Analysis of the possible confounding effects of cytotoxicity and exogenous metabolism on in vitro genotoxicity assessments." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/analysis-of-the-possible-confounding-effects-of-cytotoxicity-and-exogenous-metabolism-on-in-vitro-genotoxicity-assessments(cefcc3f8-bf05-4c10-b8e4-41881f01c4a4).html.

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Recent evaluations of the regulatory in vitro genotoxicity tests have revealed that the mammalian cell tests are sensitive for the prediction of rodent carcinogenicity, but not very specific; they produce positive results for many non-carcinogens. Studies to investigate the potential causes of this poor specificity have focused on the high test concentrations of chemicals and the often associated high cytotoxicity. Others have sought to develop alternative in vitro assays that retain high sensitivity but also have higher specificity. One such test is the GADD45a-GFP “GreenScreen HC” genotoxici

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Midander, Klara. "Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11695.

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Mobio, Théophile Amondo. "Effets génotoxiques et épigénétiques de la fumonisine B1 in vitro : études des mécanismes moléculaires et prévention." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28804.

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Xu, Ke. "Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanate and their cysteine adducts in vitro." Thesis, University of Essex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327095.

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Lage, Thais Claudino. "Análise in vitro da citotoxicidade em osteoblastos de dispositivos poliméricos incorporados com antimicrobianos para uso local." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-27112017-154525/.

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Os osteoblastos são células de origem mesenquimal envolvidas na formação óssea. Essas células podem sofrer alterações decorrentes de traumas, intervenções, e infecções. As infecções podem ser minimizadas a partir do uso de antimicrobianos. O poli(L-lactídeo) ou PLLA, é um polímero sintético que se destaca por sua biocompatibilidade e absorção, o qual pode ser utilizado como um liberador farmacológico local, como alternativa à terapêutica antimicrobiana sistêmica. Esse polímero também é empregado como matriz de suporte celular na engenharia de tecidos ósseos, por auxiliar na reparação e regener

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El, Mzibri Mohammed. "Le Salmonella sulA-test : un nouveau test in vitro pour la détection de produits génotoxiques." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22094.

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L'induction des fonctions sos chez les bacteries est un bon outil pour la detection de produits genotoxiques. Dans le but de creer un nouveau test impliquant les fonctions sos, nous avons essaye de placer le gene lacz sous controle d'un gene inductible du prophage fels2 dans la souche salmonella typhimurium ta1538 en utilisant le phage hybride lambda-placmu. Nos resultats montrent que la transposition dans la souche ta1538lamb#+ est impossible. En effet, la presence de la mutation rfae confere a la souche une resistance a l'infection par le phage lambda ou ses derives en empechant la fixation

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González, Arias Cyndia Azucena. "In vitro bioaccessibility of ochratoxin A and assessment of its cytotoxicity and genotoxicity in human cell cultures." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/305367.

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L’ocratoxina A (OTA) és una micotoxina produïda per vàries espècies de fongs del gènere Aspergillus i Penicillium. L’OTA és una de les micotoxines més ubiques, ja que a nivell mundial s’ha trobat en una gran varietat d’aliments tant d’origen vegetal com d’animal. Els productes per a consum humà elaborats a base de cereals són el grup d’aliments que presenta una major contaminació d’OTA. El vi és un altre aliment que freqüentment es troba contaminat amb OTA i que pot tenir una important contribució en quan a l’exposició humana d’aquesta micotoxina. Estudis realitzats en rosegadors han demostrat

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Miller, Michelle Teresa. "In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/51673.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2009.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references.<br>Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, chemotherapy, hormones, or immunotherapy. However, currently there are many issues with these form

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Oliveira, Carlos Fernando Araujo Lima de. "Investigação da atividade toxicológica de análogos de estatinas em modelos experimentais in vitro." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7298.

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Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro<br>As estatinas são fármacos inibidores competitivos da enzima hidroxi-3-metil-glutaril Coenzima A (HMGCoA) redutase, amplamente utilizados para o controle da hipercolesterolemia total e, em especial, para a redução dos níveis séricos de LDLc (Low Density Lipoprotein cholesterol). Além do efeito primário, esses fármacos apresentam vários efeitos secundários, chamados de efeitos pleiotrópicos, envolvendo atividade anti-inflamatória, antitumoral e antiparasitária. Para o desenvolvimento de inovações na área de química medicinal é impresci

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Gomes, Juliana Pizarro Martins [UNESP]. "Pesquisa de atividade antitumoral e mutagênica in vitro de produtos naturais." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/97908.

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Made available in DSpace on 2014-06-11T19:29:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-04-14Bitstream added on 2014-06-13T20:19:00Z : No. of bitstreams: 1 gomes_jpm_me_arafcf.pdf: 701791 bytes, checksum: cd29e183b510cd091b271dae4deccba3 (MD5)<br>O presente trabalho avaliou a citotoxicidade in vitro de produtos naturais (terpenos, iridóides e derivados fenólicos) em linhagens celulares de adenocarcinoma murino de mama (LM3) e de pulmão (LP07), buscando uma possível correlação entre estrutura molecular e atividade antitumoral. A ordem de citotoxicidade na linhagem LM3 foi tinge

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Lessa, Fernanda Campos [UNESP]. "Citotoxicidade direta e transdentinária da clorexidina sobre células odontoblastóides MDPC-23 e análise de sua atividade antimicrobiana in vitro." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/104257.

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Made available in DSpace on 2014-06-11T19:33:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-08-18Bitstream added on 2014-06-13T19:22:59Z : No. of bitstreams: 1 lessa_fcr_dr_arafo.pdf: 4260399 bytes, checksum: 525a03c2dd993eddd2a9e6fcabbbc84b (MD5)<br>O objetivo da presente pesquisa foi avaliar o efeito citotóxico direto e transdentinário de diferentes concentrações de clorexidina (CHX), bem como sua atividade antibacteriana. Para isto, concentrações de 0,06%; 0,12%; 0,2%; 1% e 2% de CHX foram aplicadas sobre células odontoblastóides MDPC-23 em cultura (teste direto). Além disto,

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Coyle, Jayme. "The Assessment of an In-vitro Model for Evaluating the Role of PARP in Ethanol-mediated Hepatotoxicity." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4810.

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This investigation assesses the role of poly(ADP-ribose) polymerase in ethanol-mediated hepatotoxicity using the untransfected HepG2 hepatocellular carcinoma line, an established, well-characterized toxicological model. HepG2 cells were treated with ethanol at concentrations between 100 mM and 800 mM, and assessed for markers of cytotoxicity. PARP-1 activity in total cell protein lysates was quantified as a proxy of apoptotic induction at six hours. Our results demonstrated a 1.43-fold AST activity increase in culture medium isolates of cells exposed to 800 mM without significant effect on cel

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Maja, Matshidiso Patricia. "In Vitro cytotoxicity and antibacterial activity of selected South African medicinal plants used in the treatment of periodontitis." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/24855.

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The use of medicinal plants in the treatment of infectious diseases is an acceptable and popular phenomenon in South Africa and worldwide. The potential of extracts from these plants as antimicrobial agents necessitates their scientific evaluation. Therefore, this study evaluated the antimicrobial activity of Carpobrotus edulis; Cotyledon orbiculata; Datura stramonium; Dodonaea angustifolia; and Zanthoxylum capense against Porphyromonas gingivalis; Tannerella forsythensis and Actinobacillus actinomycetemcomitan. Given that most currently used drugs are cytotoxic, the possible cytotoxic effect

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Marlot, Philippe. "In vitro evaluation of cytotoxicity caused by carbamazepine and its metabolites in association to carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2025988/.

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Carbamazepine (CBZ), an anticonvulsant and mood-stabilising drug, is known to cause delayed type hypersensitivity reactions. These reactions occur only in a minority of patients treated with the drug, but often result in severe clinical outcomes. Although an association between CBZ-induced hypersensitivity reactions and HLA alleles has been demonstrated, the underlying mechanism(s) of toxicity are poorly understood. Cell death caused by CBZ and one of its metabolites, 9-acridinecarboxaldehyde (9-AC) was investigated. CBZ did not show cytotoxic effects in concentrations ranging from sub-therape

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Nagai, Hiroki. "Nitric oxide enhances pemetrexed cytotoxicity via NO-cGMP signaling in lung adenocarcinoma cells in vitro and in vivo." Kyoto University, 2013. http://hdl.handle.net/2433/170074.

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Masango, Mxolisi Goodwill. "A comparative analysis of the cytotoxicity of cyanotoxins using in vitro (cell culture) and in vivo (mouse) assays." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-100402/.

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Riera, Tur Irene [Verfasser], and Rüdiger [Akademischer Betreuer] Klein. "Artificial amyloid-like aggregating proteins cause cytotoxicity in vitro and in vivo / Irene Riera Tur ; Betreuer: Rüdiger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1204005397/34.

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