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Artykuły w czasopismach na temat „Lipid”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Schilke, Robert Michael, Cassidy M. R. Blackburn, Shashanka Rao, David M. Krzywanski, and Matthew D. Woolard. "Macrophage-associated lipin-1 regulates lipid catabolism to promote effective efferocytosis." Journal of Immunology 204, no. 1_Supplement (2020): 69.22. http://dx.doi.org/10.4049/jimmunol.204.supp.69.22.

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Abstract Failure to resolve inflammation leads to numerous chronic diseases. Disease resolution requires the effective removal of dead cells by macrophage-mediated efferocytosis. Excess lipid accumulation within macrophages can lead to dysfunction that promotes disease pathogenesis. Efferocytosis results in a significant accumulation of lipid inside the macrophage, yet macrophage continue to function. This suggest that during efferocytosis, macrophages have pathways to ameliorate the high lipid load. We have identified that lipin-1, a regulator of lipid metabolism, is critical to proper macrop

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Hallett, Nanette. "Lipids and Lipid Disorders." Dimensions of Critical Care Nursing 10, no. 6 (1991): 345. http://dx.doi.org/10.1097/00003465-199111000-00011.

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Jaswinder, Singh *. "LIPID NANOPARTICULATE DRUG DELIVERY SYSTEMS." Journal of Pharma Research 8, no. 8 (2019): 557–63. https://doi.org/10.5281/zenodo.3374087.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>olloidal particles of size range between 10 and 1000 nm are known as nanoparticles. Over the last few years, lipid based drug delivery systems such as solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) and lipid drug conjugate (LDC) have become the most promising drug delivery systems. Each preparation of the lipid based nanoparticles has advantages and disadvantages with respect to specific characteristics. The SLN is an excellent drug delivery system and has extensive prospects in the pharmaceutical field. N

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Lee, Anthony G. "Lipid–protein interactions." Biochemical Society Transactions 39, no. 3 (2011): 761–66. http://dx.doi.org/10.1042/bst0390761.

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Intrinsic membrane proteins are solvated by a shell of lipid molecules interacting with the membrane-penetrating surface of the protein; these lipid molecules are referred to as annular lipids. Lipid molecules are also found bound between transmembrane α-helices; these are referred to as non-annular lipids. Annular lipid binding constants depend on fatty acyl chain length, but the dependence is less than expected from models based on distortion of the lipid bilayer alone. This suggests that hydrophobic matching between a membrane protein and the surrounding lipid bilayer involves some distorti

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RAJ, BRITO. "Investigating the influence of lipids on Nano-structured lipid carrier formulation." Journal of Medical pharmaceutical and allied sciences 12, no. 6 (2023): 6147–54. http://dx.doi.org/10.55522/jmpas.v12i6.5220.

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The study aimed to evaluate the effect of different lipids on the properties of nanostructured lipid carrier (NLC) formulations. The particle size, zeta potential, polydispersity index, entrapment efficiency, and drug release at 24 hours were analyzed for formulations containing various lipid matrices. Among the formulations tested, N3 (Compritol 888 ATO and Softigen) exhibited the most favourable characteristics, including the smallest particle size, highest entrapment efficiency, sustained drug release, and good stability, as indicated by a high zeta potential. Other lipids, such as Witepsol

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Clark, Robert B., Jorge L. Cervantes, Mark W. Maciejewski, et al. "Serine Lipids of Porphyromonas gingivalis Are Human and Mouse Toll-Like Receptor 2 Ligands." Infection and Immunity 81, no. 9 (2013): 3479–89. http://dx.doi.org/10.1128/iai.00803-13.

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ABSTRACTThe total cellular lipids ofPorphyromas gingivalis, a known periodontal pathogen, were previously shown to promote dendritic cell activation and inhibition of osteoblasts through engagement of Toll-like receptor 2 (TLR2). The purpose of the present investigation was to fractionate all lipids ofP. gingivalisand define which lipid classes account for the TLR2 engagement, based on bothin vitrohuman cell assays andin vivostudies in mice. Specific serine-containing lipids ofP. gingivalis, called lipid 654 and lipid 430, were identified in specific high-performance liquid chromatography frac

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7

Kamisaka, Y., and N. Noda. "Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus." Biochemical Society Transactions 28, no. 6 (2000): 723–25. http://dx.doi.org/10.1042/bst0280723.

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Fluorescent phosphatidic acid and phosphatidylcholine were used to characterize lipid-transport pathways into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora. Several characteristics of the lipid transport such as temperature dependence and ATP dependence were evaluated. The transport depicted by these fluorescent lipids was consistent with metabolism of radiolabelled lipids, indicating that fluorescent lipids are useful to study lipid-body formation in this fungus. The results dissect lipid transport of phosphatidic acid and phosphatidylcholine into lipid bodies

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8

Tamura, Yasushi, Shin Kawano, and Toshiya Endo. "Lipid homeostasis in mitochondria." Biological Chemistry 401, no. 6-7 (2020): 821–33. http://dx.doi.org/10.1515/hsz-2020-0121.

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AbstractMitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles

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9

Kirby, Mike. "Lipids and lipid‐modifying therapy." Trends in Urology & Men's Health 12, no. 3 (2021): 23–28. http://dx.doi.org/10.1002/tre.803.

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ISHIMOTO, Kenji. "Lipin 1 in Lipid Metabolism." YAKUGAKU ZASSHI 131, no. 8 (2011): 1189–94. http://dx.doi.org/10.1248/yakushi.131.1189.

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11

Nakmode, Deepa, Valamla Bhavana, Pradip Thakor, et al. "Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development." Pharmaceutics 14, no. 4 (2022): 831. http://dx.doi.org/10.3390/pharmaceutics14040831.

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Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mec

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12

Bamgbose, Temitayo Taiwo, Robert M. Schilke, Cassidy M. R. Blackburn, and Matthew D. Woolard. "Lipin-1 restrains lipid synthesis to promote proresolving macrophage function and disease resolution." Journal of Immunology 208, no. 1_Supplement (2022): 54.23. http://dx.doi.org/10.4049/jimmunol.208.supp.54.23.

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Abstract Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. Unresolved inflammation contributes to the pathophysiology of cardiometabolic diseases. The lipid metabolic state of macrophages influences their function. Lipid synthesis contributes to proinflammatory responses, while beta-oxidation is required for pro-resolving macrophage function. However, how lipid metabolism is regulated during macrophage activation is not well understood. Lipin-1 is a phosphatidic acid phosphatase with a transcriptional coregulatory activity that is proposed to act as

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13

Coen, Luisa, Daniel Alexander Kuckla, Andreas Neusch, and Cornelia Monzel. "Mobile and Immobile Obstacles in Supported Lipid Bilayer Systems and Their Effect on Lipid Mobility." Colloids and Interfaces 8, no. 5 (2024): 54. http://dx.doi.org/10.3390/colloids8050054.

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Diffusion and immobilization of molecules in biomembranes are essential for life. Understanding it is crucial for biomimetic approaches where well-defined substrates are created for live cell assays or biomaterial development. Here, we present biomimetic model systems consisting of a supported lipid bilayer and membrane coupled proteins to study the influence of lipid–lipid and lipid–protein interactions on membrane mobility. To characterize the diffusion of lipids or proteins, the continuous photobleaching technique is used. Either Neutravidin coupled to DOPE-cap-Biotin lipids or GFP coupled

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14

Kobayashi, Toshihide, Feng Gu, and Jean Gruenberg. "Lipids, lipid domains and lipid–protein interactions in endocytic membrane traffic." Seminars in Cell & Developmental Biology 9, no. 5 (1998): 517–26. http://dx.doi.org/10.1006/scdb.1998.0257.

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15

Gretskaya, Nataliya, Mikhail Akimov, Dmitry Andreev, et al. "Multicomponent Lipid Nanoparticles for RNA Transfection." Pharmaceutics 15, no. 4 (2023): 1289. http://dx.doi.org/10.3390/pharmaceutics15041289.

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Despite the wide variety of available cationic lipid platforms for the delivery of nucleic acids into cells, the optimization of their composition has not lost its relevance. The purpose of this work was to develop multi-component cationic lipid nanoparticles (LNPs) with or without a hydrophobic core from natural lipids in order to evaluate the efficiency of LNPs with the widely used cationic lipoid DOTAP (1,2-dioleoyloxy-3-[trimethylammonium]-propane) and the previously unstudied oleoylcholine (Ol-Ch), as well as the ability of LNPs containing GM3 gangliosides to transfect cells with mRNA and

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16

Abdullah Q. Khudhur, Nidhal K. Maraie, and Ayad M.R. Raauf. "Highlight on lipids and its use for covalent and non-covalent conjugations." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 3 (2020): 1–13. http://dx.doi.org/10.32947/ajps.v20i3.754.

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Lipids are organic fatty or waxy compounds which are used to make nanocarriers that are promising for drug delivery. When lipids associated covalently (lipid-drug conjugate LDC) or non- covalently (drug-lipid complex) to drugs to form Lipid Drug Conjugates (LDC). Most common types of lipids  used for drug conjugation are fatty acids, glycerides, steroids, and phospholipids. Conjugation with lipids may change the properties of the drug and significantly increase the drug lipophilicity. Lipid-drug conjugation could improve the delivery of drugs by the lymphatic system, enhance bioava

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17

Florance, Ida, and Seenivasan Ramasubbu. "Current Understanding on the Role of Lipids in Macrophages and Associated Diseases." International Journal of Molecular Sciences 24, no. 1 (2022): 589. http://dx.doi.org/10.3390/ijms24010589.

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Lipid metabolism is the major intracellular mechanism driving a variety of cellular functions such as energy storage, hormone regulation and cell division. Lipids, being a primary component of the cell membrane, play a pivotal role in the survival of macrophages. Lipids are crucial for a variety of macrophage functions including phagocytosis, energy balance and ageing. However, functions of lipids in macrophages vary based on the site the macrophages are residing at. Lipid-loaded macrophages have recently been emerging as a hallmark for several diseases. This review discusses the significance

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18

Ahire, Sandip Barku, and Ravindra Keshavrao Kamble. "A Concise review on application of solid lipids and various techniques in the formulation development." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 87–97. http://dx.doi.org/10.22270/jddt.v13i5.5817.

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Lipids have wide range of applications in food and pharmaceuticals. The pharmaceuticals application of lipid is to improve solubility of drug also helps to improve the bioavailability. The dissolution/dissolving phase, which is probably the rate-limiting component for oral absorption of poorly water-soluble drugs, is eliminated by pre-dissolving pharmaceuticals in lipids, surfactants, or combinations of lipid excipients and surfactants. The most widely used co-solvents, together with lipid excipients, are propylene glycol, glycerol, and polyethylene glycols-400, poloxamer etc. various technolo

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19

Dowds, C. Marie, Sabin-Christin Kornell, Richard S. Blumberg, and Sebastian Zeissig. "Lipid antigens in immunity." Biological Chemistry 395, no. 1 (2014): 61–81. http://dx.doi.org/10.1515/hsz-2013-0220.

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Abstract Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and modulate immunity as intracellular phospholipid- or sphingolipid-derived signaling mediators. In addition, lipids can serve as antigens and regulate immunity through the activation of lipid-reactive T cells, which is the topic of this review. We will provide an overv

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20

Eyster, Kathleen M. "The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist." Advances in Physiology Education 31, no. 1 (2007): 5–16. http://dx.doi.org/10.1152/advan.00088.2006.

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Reviews of signal transduction have often focused on the cascades of protein kinases and protein phosphatases and their cytoplasmic substrates that become activated in response to extracellular signals. Lipids, lipid kinases, and lipid phosphatases have not received the same amount of attention as proteins in studies of signal transduction. However, lipids serve a variety of roles in signal transduction. They act as ligands that activate signal transduction pathways as well as mediators of signaling pathways, and lipids are the substrates of lipid kinases and lipid phosphatases. Cell membranes

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21

Evans, Thomas M., and Shale Beharie. "Are lipids always depleted? Comparison of hydrogen, carbon, and nitrogen isotopic values in the muscle and lipid of larval lampreys." PLOS ONE 19, no. 1 (2024): e0286535. http://dx.doi.org/10.1371/journal.pone.0286535.

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Stable isotope ratios in organisms can be used to estimate dietary source contributions, but lipids must first be accounted for to interpret values meaningfully. Lipids are depleted in heavy isotopes because during lipid synthesis light isotopes of carbon (12C) and hydrogen (1H) are preferentially incorporated. Prior work in larval lampreys has noted unusual lipid effects, which suggest lipids are enriched in the heavy isotope of carbon (13C), but still depleted in the heavy isotope of hydrogen (deuterium; 2H); nitrogen, a relatively rare element in lipids, has not been identified as being as

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Kao, Yu-Chia, Pei-Chuan Ho, Yuan-Kun Tu, I.-Ming Jou, and Kuen-Jer Tsai. "Lipids and Alzheimer’s Disease." International Journal of Molecular Sciences 21, no. 4 (2020): 1505. http://dx.doi.org/10.3390/ijms21041505.

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Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer’s disease (AD). Aging is associated with changes in lipid composition. Alterations of fatty acids at the level of lipid rafts and cerebral lipid peroxidation were found in the early stage of AD. Genetic and environmental factors such as apolipoprotein and lipid transporter carrying status and dietary lipid content a

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Zhang, Yongli, Jinghua Ge, Xin Bian, and Avinash Kumar. "Quantitative Models of Lipid Transfer and Membrane Contact Formation." Contact 5 (January 2022): 251525642210960. http://dx.doi.org/10.1177/25152564221096024.

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Lipid transfer proteins (LTPs) transfer lipids between different organelles, and thus play key roles in lipid homeostasis and organelle dynamics. The lipid transfer often occurs at the membrane contact sites (MCS) where two membranes are held within 10–30 nm. While most LTPs act as a shuttle to transfer lipids, recent experiments reveal a new category of eukaryotic LTPs that may serve as a bridge to transport lipids in bulk at MCSs. However, the molecular mechanisms underlying lipid transfer and MCS formation are not well understood. Here, we first review two recent studies of extended synapto

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Exterkate, Marten. "The role of lipid biosynthesis machinery in cellular membrane adaptation." BIOspektrum 30, no. 6 (2024): 625–28. http://dx.doi.org/10.1007/s12268-024-2316-5.

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AbstractCells need to adapt their membranes to environmental changes. In this process the specific lipid composition of the membrane is of importance. The lipid biosynthesis machinery has direct influence on the membrane lipid content by 1) producing newly synthesized lipids, 2) remodeling already existing lipids, such as various cardiolipins. The interactions between components of the lipid biosynthesis machinery are crucial to obtain a specific lipid composition, but the interplay is largely unknown.

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Maxwell, Robert J. "Determination of Total Lipid and Lipid Subclasses in Meat and Meat Products." Journal of AOAC INTERNATIONAL 70, no. 1 (1987): 74–77. http://dx.doi.org/10.1093/jaoac/70.1.74.

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Abstract Current interest in physiological and nutritional activities of the sterol, polyunsaturated fatty acid, and polar lipid fractions of meats and other foods indicates that analytical methods for lipids should be evaluated on their ability to recover and quantitate these classes. Current methods of lipid isolation furnish an extract that is dependent on the solvent(s) used, the type of food material, the temperature of extraction, and the relative proportions of the lipid classes present. Extraction with ethers or other relatively nonpolar solvents removes principally the neutral fats an

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Wang, Zhen, and Christoph Benning. "Chloroplast lipid synthesis and lipid trafficking through ER–plastid membrane contact sites." Biochemical Society Transactions 40, no. 2 (2012): 457–63. http://dx.doi.org/10.1042/bst20110752.

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Plant chloroplasts contain an intricate photosynthetic membrane system, the thylakoids, and are surrounded by two envelope membranes at which thylakoid lipids are assembled. The glycoglycerolipids mono- and digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol as well as phosphatidylglycerol, are present in thylakoid membranes, giving them a unique composition. Fatty acids are synthesized in the chloroplast and are either directly assembled into thylakoid lipids at the envelope membranes or exported to the ER (endoplasmic reticulum) for extraplastidic lipid assembly. A fraction of lipi

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Kamiya, Koki, Chika Arisaka, and Masato Suzuki. "Investigation of Fusion between Nanosized Lipid Vesicles and a Lipid Monolayer Toward Formation of Giant Lipid Vesicles with Various Kinds of Biomolecules." Micromachines 12, no. 2 (2021): 133. http://dx.doi.org/10.3390/mi12020133.

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We determined the properties of fusion between large unilamellar vesicles (LUVs) and the lipid monolayer by measuring the fluorescence intensity of rhodamine-conjugated phospholipids in cell-sized lipid vesicles. The charge of LUVs (containing cationic lipids) and lipid droplets (containing anionic lipids) promoted lipid membrane fusion. We also investigated the formation of cell-sized lipid vesicles with asymmetric lipid distribution using this fusion method. Moreover, cell-sized asymmetric ganglioside vesicles can be generated from the planar lipid bilayer formed at the interface between the

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Kon, Takahide, Naoki Nemoto, Tairo Oshima, and Akihiko Yamagishi. "Effects of a Squalene Epoxidase Inhibitor, Terbinafine, on Ether Lipid Biosyntheses in a Thermoacidophilic Archaeon, Thermoplasma acidophilum." Journal of Bacteriology 184, no. 5 (2002): 1395–401. http://dx.doi.org/10.1128/jb.184.5.1395-1401.2002.

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ABSTRACT The archaeal plasma membrane consists mainly of diether lipids and tetraether lipids instead of the usual ester lipids found in other organisms. Although a molecule of tetraether lipid is thought to be synthesized from two molecules of diether lipids, there is no direct information about the biosynthetic pathway(s) or intermediates of tetraether lipid biosynthesis. In this study, we examined the effects of the fungal squalene epoxidase inhibitor terbinafine on the growth and ether lipid biosyntheses in the thermoacidophilic archaeon Thermoplasma acidophilum. Terbinafine was found to i

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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have b

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Nichols, Frank C., Bekim Bajrami, Robert B. Clark, William Housley, and Xudong Yao. "Free Lipid A Isolated from Porphyromonas gingivalis Lipopolysaccharide Is Contaminated with Phosphorylated Dihydroceramide Lipids: Recovery in Diseased Dental Samples." Infection and Immunity 80, no. 2 (2011): 860–74. http://dx.doi.org/10.1128/iai.06180-11.

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ABSTRACTRecent reports indicate thatPorphyromonas gingivalismediates alveolar bone loss or osteoclast modulation through engagement of Toll-like receptor 2 (TLR2), though the factors responsible for TLR2 engagement have yet to be determined. Lipopolysaccharide (LPS) and lipid A, lipoprotein, fimbriae, and phosphorylated dihydroceramides ofP. gingivalishave been reported to activate host cell responses through engagement of TLR2. LPS and lipid A are the most controversial in this regard because conflicting evidence has been reported concerning the capacity ofP. gingivalisLPS or lipid A to engag

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Senevirathna, Jayan D. M., and Shuichi Asakawa. "Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales." Life 11, no. 4 (2021): 364. http://dx.doi.org/10.3390/life11040364.

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Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to investigate lipid metabolism and radiation impacts on lipids in toothed whales. The selected literature was screened, and capacities, possibilities, and future approaches for identifying unusual lipid synthesis pathways by omics were evaluated. Omics approaches were categorized into the four major

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Cabodevilla, Ainara G., Ni Son, and Ira J. Goldberg. "Intracellular lipase and regulation of the lipid droplet." Current Opinion in Lipidology 35, no. 2 (2024): 85–92. http://dx.doi.org/10.1097/mol.0000000000000918.

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Purpose of review Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues. Recent findings There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years. These include new informatio

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Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

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At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

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Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

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At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

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Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

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At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

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Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

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At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

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Wang, Xuewei, Hai Bui, Prashanthi Vemuri, et al. "Lipidomic Network of Mild Cognitive Impairment from the Mayo Clinic Study of Aging." Journal of Alzheimer's Disease 81, no. 2 (2021): 533–43. http://dx.doi.org/10.3233/jad-201347.

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Background: Lipid alterations contribute to Alzheimer’s disease (AD) pathogenesis. Lipidomics studies could help systematically characterize such alterations and identify potential biomarkers. Objective: To identify lipids associated with mild cognitive impairment and amyloid-β deposition, and to examine lipid correlation patterns within phenotype groups Methods: Eighty plasma lipids were measured using mass spectrometry for 1,255 non-demented participants enrolled in the Mayo Clinic Study of Aging. Individual lipids associated with mild cognitive impairment (MCI) were first identified. Correl

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Warren, Charles R. "Altitudinal transects reveal large differences in intact lipid composition among soils." Soil Research 59, no. 6 (2021): 644. http://dx.doi.org/10.1071/sr20055.

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Fatty acid-based lipids comprise a small but important component of soil organic matter. Lipids are indispensable components of soil microbes due to their function as components of membranes and as stores of energy and C. Hence, lipid composition is likely under strong selection pressure and there ought to be strong associations between lipid composition of microbial communities and environmental conditions. Associations between microbial lipids and environment likely involve an integrated combination of differences in lipid headgroups (classes) and fatty acyl chains. However, past studies exa

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Kloska, Anna, Magdalena Węsierska, Marcelina Malinowska, Magdalena Gabig-Cimińska, and Joanna Jakóbkiewicz-Banecka. "Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases." International Journal of Molecular Sciences 21, no. 17 (2020): 6113. http://dx.doi.org/10.3390/ijms21176113.

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This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway ys communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases. Answers to these questions will likely uncover novel strategies for the treatment of aforementioned human diseases, but, above all, will avoid destructive effects of high concentrations of lipids—referred to as lipotoxicity—resulting in cellular dysfunction and cell death.

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Rochman, M. Fatchur, Aditya Darmawan, and Pramudya Wardhana. "Nanostructured Lipid Carriers System Solid Lipid Poloxamer and Stearic Acid with Liquid Lipid Soybean Oil." Jurnal Ilmiah Medicamento 8, no. 1 (2022): 1–7. http://dx.doi.org/10.36733/medicamento.v8i1.3161.

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Nanostructured Lipid Carriers (NLC) are lipid-based carrier system that use a matrix combination in the form of solid and liquid which are stabilized with the addition of surfactant. This NLC was developed to facilitate the dispersion of hydrophobic bioactive compound in a hydrophilic system. This research aims to get the right formulation and can develop stable characterization, using solid lipids Poloxamer and Stearic Acid with liquid lipids Soybeans Oil using surfactant Tween 80 and co-surfactant Propyleneglycol.. The to make the formulation of NLC with a ratio of poloxamer and stearic acid

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Passos Gibson, Victor, Martin Fauquignon, Emmanuel Ibarboure, Jeanne Leblond Chain, and Jean-François Le Meins. "Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes." Polymers 12, no. 3 (2020): 637. http://dx.doi.org/10.3390/polym12030637.

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Blending amphiphilic copolymers and lipids constitutes a novel approach to combine the advantages of polymersomes and liposomes into a new single hybrid membrane. Efforts have been made to design stimuli-responsive vesicles, in which the membrane’s dynamic is modulated by specific triggers. In this investigation, we proposed the design of pH-responsive hybrid vesicles formulated with poly(dimethylsiloxane)-block-poly(ethylene oxide) backbone (PDMS36-b-PEO23) and cationic switchable lipid (CSL). The latter undergoes a pH-triggered conformational change and induces membrane destabilization. Usin

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Boyd, Ben J., and Andrew J. Clulow. "The influence of lipid digestion on the fate of orally administered drug delivery vehicles." Biochemical Society Transactions 49, no. 4 (2021): 1749–61. http://dx.doi.org/10.1042/bst20210168.

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This review will focus on orally administered lipid-based drug delivery vehicles and specifically the influence of lipid digestion on the structure of the carrier lipids and their entrained drug cargoes. Digestion of the formulation lipids, which are typically apolar triglycerides, generates amphiphilic monoglycerides and fatty acids that can self-assemble into a diverse array of liquid crystalline structures. Tracking the dynamic changes in self-assembly of the lipid digestion products during digestion has recently been made possible using synchrotron-based small angle X-ray scattering. The i

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Paul Aboubechara, John, Haitham Maraqah, Mones Abu-Asab, Han Sung Lee, and Orwa Aboud. "TMIC-19. EXCESSIVE LIPID PRODUCTION SHAPES GLIOMA TUMOR MICROENVIRONMENT." Neuro-Oncology 26, Supplement_8 (2024): viii301. http://dx.doi.org/10.1093/neuonc/noae165.1197.

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Abstract Disrupted lipid metabolism is a characteristic of gliomas. This study utilizes an ultrastructural approach to characterize the prevalence and distribution of lipids within gliomas. This study made use of tissue from IDH1 wild type (IDH1-wt) glioblastoma (n=18) and IDH1 mutant (IDH1-mt) astrocytoma (n=12) tumors. We uncover a prevalent and intriguing surplus of lipids. The bulk of the lipids manifested as sizable cytoplasmic inclusions and extracellular deposits in the tumor microenvironment (TME); in some tumors the lipids were stored in the classical membraneless spheroidal lipid dro

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Woolard, Matthew D., Cassidy Blackburn, Robert Schilke, and Temitayo Bamgbose. "Lipin-1 integrates lipid metabolism with macrophage function to promote inflammation resolution." Journal of Immunology 208, no. 1_Supplement (2022): 111.06. http://dx.doi.org/10.4049/jimmunol.208.supp.111.06.

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Abstract Free fatty acid accumulation in macrophages alters cellular metabolism, leading to failed inflammation resolution that contributes to cardiometabolic pathologies such as atherosclerotic cardiovascular disease. Free fatty acids are either broken down by β-oxidation, stored in glycerolipids, or incorporated into sphingolipids (e.g., ceramides). Ceramide synthesis inhibits several pro-resolving macrophage functions, such as β-oxidation and efferocytosis, needed for inflammation resolution. The regulatory signals that control free fatty acid incorporation into lipids (e.g., lipid channeli

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Limaye, Akhilesh Dr. Shaikh Nasheer* Humnabade Shital Anantwal Akshat Babhulkar Akshay Joshi Maharudra Rajput Amrapali. "Comprehensive Review on Nanostructured Lipid Carriers." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3423–31. https://doi.org/10.5281/zenodo.15474137.

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Nanostructured lipid carriers (NLCs) represent a novel nanoparticulate drug delivery system composed of solid lipids, liquid lipids, emulsifying agents, and an aqueous phase. In recent years, NLCs have garnered considerable scientific and clinical interest due to their superior drug delivery capabilities, offering notable advantages over conventional dosage forms. Nanostructured lipid carriers (NLCs) are second generation lipid-based nanocarriers formulated using biocompatible solid lipids, liquid lipids, surfactants, and co-surfactants. These systems are capable of encapsulating a wide range

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Patil, Deepak, Seema Pattewar, Sarvesh Palival, Gargi Patil, and Swapnil Sharma. "Nanostructured lipid carriers: A platform to lipophilic drug for oral bioavailability enhancement." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 758–64. http://dx.doi.org/10.22270/jddt.v9i3-s.2750.

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Lipid based drug delivery system such as Solid lipid nanoparticle (SLN) and Nanostructured lipid carriers (NLC) are among the most promising drug delivery system used in many industries such as food, pharmaceuticals and cosmetics industries. Over the last few years, new constituents of lipids have developed and investigated for enhancement of bioavailability. The present manuscript is an attempt on solving the concerned uncertainty with efficacious peroral administration of hydrophobic drugs through fabricating new lipid formulations, NLC. NLC, the second-generation lipid carrier is usually co

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Saito, Kosuke, Kotaro Hattori, Shinsuke Hidese, et al. "Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans." Metabolites 11, no. 5 (2021): 268. http://dx.doi.org/10.3390/metabo11050268.

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Lipidomics provides an overview of lipid profiles in biological systems. Although blood is commonly used for lipid profiling, cerebrospinal fluid (CSF) is more suitable for exploring lipid homeostasis in brain diseases. However, whether an individual’s background affects the CSF lipid profile remains unclear, and the association between CSF and plasma lipid profiles in heathy individuals has not yet been defined. Herein, lipidomics approaches were employed to analyze CSF and plasma samples obtained from 114 healthy Japanese subjects. Results showed that the global lipid profiles differed signi

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Talapatra, Jyotirmayee, and Mamatha M. Reddy. "Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification." Cancers 15, no. 7 (2023): 2144. http://dx.doi.org/10.3390/cancers15072144.

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Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions

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Galper, Jasmin, Woojin S. Kim, and Nicolas Dzamko. "LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease." Biomolecules 12, no. 11 (2022): 1597. http://dx.doi.org/10.3390/biom12111597.

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Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a common risk factor for Parkinson’s disease. How LRRK2 alterations lead to cell pathology is an area of ongoing investigation, however, multiple lines of evidence suggest a role for LRRK2 in lipid pathways. It is increasingly recognized that in addition to being energy reservoirs and structural entities, some lipids, including neural lipids, participate in signaling cascades. Early investigations revealed that LRRK2 localized to membranous and vesicular structures, suggesting an interaction of LRRK2 and lipids o

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Garcia, Chelsea, Catherine J. Andersen, and Christopher N. Blesso. "The Role of Lipids in the Regulation of Immune Responses." Nutrients 15, no. 18 (2023): 3899. http://dx.doi.org/10.3390/nu15183899.

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Lipid metabolism plays a major role in the regulation of the immune system. Exogenous (dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct role in regulating immune cell activation, differentiation and expansion, and inflammatory phenotypes. Understanding the complexities of lipid–immune interactions may have important implications for human health, as certain lipids or immune pathways may be beneficial in circumstances of acute infection yet detrimental in chronic inflammatory diseases. Further, there are key differences in the lipid effects between spec

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