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Rozprawy doktorskie na temat „Lipopolysaccharide antigens”

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Data publikacji: 3 czerwca 2025

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1

Sharma, Dharam Pal. "Non-lipopolysaccharide protective antigens of Vibrio cholerae /." Title page, abstract and contents only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phs5314.pdf.

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Savage, Catherine J. "Characterization of equine neutrophil surface antigens with an anti-β-integrin-like and two anti-CD18 monoclonal antibodies and effect of lipopolysaccharide stimulation". Thesis, Virginia Tech, 1994. http://hdl.handle.net/10919/40590.

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Savage, Catherine Jane. "Characterization of equine neutrophil surface antigens with an anti-[beta]-integrin-like and two anti-CD18 monoclonal antibodies and effect of lipopolysaccharide stimulation /." This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-01102009-064024/.

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Young, James L. "Innate Immunity in Type 2 Diabetes Pathogenesis: Role of the Lipopolysaccharide Signaling Cascade: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/400.

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Once seen as a disease of wealthy nations, type 2 diabetes mellitus is now showing unprecedented growth throughout the world, fueling increases in microvascular and macrovascular complications. A compelling and growing body of evidence suggests that glucose intolerance and insulin resistance, hallmarks of the diabetic patient, may be driven by chronic inflammation. In particular, a predominance of visceral fat has been associated with enhanced inflammatory cytokine secretion that may contribute to enhanced risk of diabetes and comorbid cardiovascular disease in these individuals. As a function

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Mohamed, Seif Eldin Ahmed. "Studies of immunity to pasteurella multocida /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu148726085949359.

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Jackson, Leila J. "The dynamic regulation of the low affinity IGE receptor by toll like receptor and B cell receptor agonists /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 122-129). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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7

Védrine, Mégane. "Rôle de l'antigène O dans la reconnaissance d'Escherichia coli par les cellules épithéliales mammaires bovines et modulation par le CD14 soluble." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR4002.

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Les mammites constituent la première source de pertes financières des cheptels bovins laitiers en France et dans le monde. Parmi les agents pathogènes des infections mammaires, Escherichia coli (E. coli) représente la bactérie majeure impliquée dans les cas de mammites cliniques aigues. La part des facteurs de l’hôte dans la capacité à éliminer le pathogène causal est en partie avérée, tandis que le lien entre caractéristiques bactériennes et sévérité de l’infection est plus délicat à établir. Cette étude s’attache donc à déterminer les facteurs bactériens importants dans les interactions entr

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8

Baker, Patrick Ericson. "Genetic regulation of virulence factors contributing to colonization and pathogenesis of helicobacter pylori." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1061414659.

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Bauwens, Ciara. "Shigella flexneri Lipopolysaccharide Modifications in the Presence of Bile Salts." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108501.

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Thesis advisor: Christina Faherty<br>Shigella, a Gram-negative bacterial pathogen, induces inflammation and diarrhea by invading the colonic epithelium. Annually, millions of Shigella infections occur globally, mainly in malnourished children. Despite extensive research, no effective vaccine exists. This work explores the mechanisms of Shigella proliferation before colonic infection, where an adverse environment is encountered, including bile salts exposure. One means of bile salts evasion is possibly lipopolysaccharide (LPS) modification. LPS—O-antigen, the polysaccharide core, and the lipid

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10

Halter, Mitchell Roy. "Characterization and differentiation of a soluble lipopolysaccharide type antigen from Treponema hyodysenteriae." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185111.

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Whole cells of T. hyodysenteriae serotypes 1-7, avirulent T. hyodysenteriae serotypes 1 and 2, and 5 strains of T. innocens were chemically extracted to selectively remove a lipopolysaccharide-like substance (LPSLS). The different LPSLS were analyzed electrophoretically, immunologically, and chemically. SDS-PAGE demonstrated migratory differences that were unique for individual serotypes/strains. Additional differences were observed during attenuation which resulted in reduced mobility of upper molecular weight components. Western blotting with hyper-immunized rabbit serum (HRS) against seroty

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11

Forestier, Claire-Lise. "Etudes des interactions entre lipopolysaccharides et cellules présentatrices d'antigènes : Le cas particulier du LPS de Brucella abortus." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX22028.

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Young, Rosanna E. B. "The lipopolysaccharide of Haemophilus parainfluenzae." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:fc7b7bcc-ea89-4ded-bb65-a1f2879236ca.

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Haemophilus parainfluenzae (Hp) and H. influenzae (Hi) are closely related members of the Pasteurellaceae family and are common commensal bacteria of the human nasopharynx. Whilst Hi is frequently implicated in meningitis, otitis media and respiratory tract infections, reports of pathogenic behaviour by Hp are very rare. Lipopolysaccharide (LPS) is a key component of the Gram negative cell wall, and its structure influences the ability of Haemophilus to interact with the host and evade immune clearance. A better understanding of the differences in LPS structure between Hi and Hp could help to

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Clay, Corey Davis. "Francisella tularensis Lipopolysaccharide O-antigen Dictates the Outcome of Human Complement Activation." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253617563.

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Voss, Söhnke. "Molecular investigations of agonists and antagonists of Toll-like receptors 2 and 4." [S.l. : s.n.], 2006.

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Czeloth, Niklas. "Steuerelemente bei der Wanderung und Funktion dendritischer Zellen funktionelle Untersuchungen zu CCR7, Sphingosin-1-Posphat und CD83 /." kostenfrei, 2007. http://d-nb.info/987042300/34.

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Nilsson, Christina. "Genome-plasticity and adaptation in Helicobacter pylori /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-189-X/.

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Campbell, Gordon R. O. (Gordon Ross Orion) 1969. "Lipopolysaccharide, K antigen, and other components of the bacterial cell surface important for S. meliloti-alfalfa symbiosis." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8581.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.<br>Includes bibliographical references (leaves 139-156).<br>Sinorhizobium meliloti can form a symbiotic relationship with alfalfa plants in which the bacteria fix atmospheric nitrogen into ammonia for the plant in exchange for nutrients. During this symbiosis, the bacteria live in organs called nodules that develop in the roots of the plant. This thesis explores a range of bacterial components necessary for an effective symbiosis. One overarching theme to these components is that most of them are involved with the b

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18

Guillorit, Christiane. "Contribution à l'étude antigénique de quatre pathovars de pseudomonas syringae : intérêt sérologique du lipopolysaccharide." Angers, 1986. http://www.theses.fr/1986ANGE0001.

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19

Marshall, Joanna M. "The O-Antigen Capsule of Salmonella Typhimurium in Acute and Chronic Infection." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385998769.

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Mouni, Fadoua. "Étude du pouvoir immunomodulateur des bifidobactéries : analyse in vitro des mécanismes moléculaires impliqués." Lille 1, 2007. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2007/50376-2007-245.pdf.

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La modulation de la réponse immunitaire est l'une des hypothèses les plus intéressantes pour expliquer les effets bénéfiques attribués aux bifidobactéries. Cependant les mécanismes moléculaires impliqués dans cette réponse sont peu étudiés. En utilisant des cellules THP-1 différenciées en macrophages et des cellules PBMC, nous avons comparé la capacité de plusieurs souches de bifidobactéries à induire la production de cytokines pro-inflammatoires et antiinflammatoires in vitro. B. Bifidum DSM 20082 s'est avérée la souche la plus stimulatrice de la production des cytokines pro-inflammatoires TN

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21

Mey, Anne. "Relation structure-activité des lipopolysaccharides : étude à l'aide d'analogues déacylés du LPS de Klebsiella pneumoniae." Lyon 1, 1996. http://www.theses.fr/1996LYO1T153.

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22

Olsson, Ulrika. "Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy." Doctoral thesis, Stockholm University, Department of Organic Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7283.

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<p>In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations.In the first two papers, the structures of O-antigen polysaccharides (PS) from two different <i>E. coli</i> bacteria were determined using NMR spectroscopy. The O-antigenic PS from <i>E. coli</i> O152 (paper I) consists of branched pentasaccharide repeating units,

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23

Khuseyinova, Natalie. "Association between plasma levels of the soluble CD14 receptor of lipopolysaccharide and the C(-260)T polymorphism in the promoter of the CD14 gene and coronary artery disease: investigations in a large case-control study." Ulm : Universität Ulm, Medizinische Fakultät, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9967025.

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Hervé, Roxane. "Rôle des phosphodiestérases de type 4 dans la signalisation du LPS des cellules chorioniques humaines." Paris 11, 2009. http://www.theses.fr/2009PA11T066.

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Villeneuve, Sylvain. "Caractérisation immunochimique des déterminants antigéniques du lipopolysaccharide de Vibrio cholerae O1 en vue de la préparation d'un vaccin anticholérique chimiquement défini." Paris 5, 1999. http://www.theses.fr/1999PA05N124.

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Soni, Shilpa. "Francisella tularensis blue-grey phase variation involves structural modifications of lipopolysaccharide O-antigen, core and lipid A and affects intramacrophage survival and vaccine efficacy." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291216526.

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Saunier, Monique. "Contribution à l'étude sérologique et taxonomique de certains pathovars de p. Syringae." Angers, 1992. http://www.theses.fr/1992ANGE0010.

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L'ensemble des travaux rapportés concernent essentiellement les pseudomonas phytopathogènes, au travers des espèces p. Cichorii, p. Viridiflava, et p. Syringae, plus spécialement les pathovars aptata, helianthi, lacrymans, morsprunorum persicae, phaseolicola, pisi, porri, savastanoi, syringae, tabaci, et tomato. La notion de profil sérologique obtenu en immunodiffusion y est définie et présentée comme un mode de lecture de la structure des chaines latérales du lipopolysaccharide. Une vingtaine de sérogroupes sont mis en évidence à l'aide d'une batterie de 24 sérums différentiels parmi un ensem

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28

Ståhle, Jonas. "Structure Elucidations of Bacterial Polysaccharides using NMR Spectroscopy and Bioinformatics." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146867.

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Carbohydrates are ubiquitous components in nature involved in a range of tasks. They cover every cell and contribute both structural stability as well as identity. Lipopolysaccharides are the outermost exposed part of the bacterial cell wall and the primary target for host-pathogen recognition. Understanding the structure and biosynthesis of these polysaccharides is crucial to combat disease and develop new medicine. Structural determinations can be carried out using NMR spectroscopy, a powerful tool giving information on an atomistic scale. This thesis is focused on method development to stud

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Cahill, Bethaney. "The Effect of O Antigen Loss on the Protein Composition and Inflammatory Response Elicited by Klebsiella pneumoniae." UNF Digital Commons, 2015. http://digitalcommons.unf.edu/etd/553.

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Klebsiella pneumoniae is a Gram-negative pathogen associated with numerous infections. Like all Gram-negative bacteria, K. pneumoniae naturally release outer membrane vesicles (OMVs) during all stages of cellular growth. OMVs are composed of the outer membrane components such as lipopolysaccharide (LPS) and outer membrane proteins and contain cytosolic and periplasmic proteins in the lumen. K. pneumoniae is often found to lack an O antigen. The absence of the O antigen has been reported to alter the protein content of the membrane which may further alter the immune response elicited by K. pneu

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Silva, Lisete Machado e. "Structural analysis of glycans and development of microarrays from Helcobacter pylori cell surface glycome." Doctoral thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15453.

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Doutoramento em Bioquímica<br>Helicobacter pylori is a bacterial pathogen that affects more than half of the world’s population with gastro-intestinal diseases and is associated with gastric cancer. The cell surface of H. pylori is decorated with lipopolysaccharides (LPSs) composed of three distinct regions: a variable polysaccharide moiety (O-chain), a structurally conserved core oligosaccharide, and a lipid A region that anchors the LPS to the cell membrane. The O-chain of H. pylori LPS, exhibits unique oligosaccharide structures, such as Lewis (Le) antigens, similar to those present

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Melchior, Aurélie. "Étude de l'activité de la cyclophiline B sur les macrophages : identification des différents sous-unités de son récepteur : mise en évidence de son activité immunorégulatrice." Lille 1, 2007. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2007/50376-2007-Melchior.pdf.

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La cyclophiline B (CyPB) est sécrétée en réponse à des stimuli inflammatoires, et induit le chimiotactisme et l'adhérence des lymphocytes T par un mécanisme dépendant des intégrines. Ces propriétés font que la CyPB est considérée comme un médiateur de la réponse inflammatoire. Son activité est dépendante de son interaction avec le CD 147 et les chaînes héparanes sulfates. Nous avons alors entrepris d'identifier le protéoglycane qui lui sert de co-récepteur. En combinant retard sur gel et ARN interférence, nous avons montré que le syndécan-1 est associé au CD147, et que la CyPB augmente et/ou s

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Rowe, Daniel C. "Analysis of Toll-Like Receptor 4 Signal Transduction and IRF3 Activation in the Innate Immune Response: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/163.

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Over the last decade, the innate immune system has been the subject of extensive research. Often overlooked by the robustness and specificity of the adaptive immune system, the innate immune system is proving to be just as complex. The identification of several families of pattern recognition receptors (PRRs) has revealed an ancient yet multifaceted system of proteins that are responsible for initiating host defense. A wide array of pathogens, from virus to bacteria, is detected using this assortment of receptors. One such family, the Toll-like receptors (TLRs), has been at the forefront of th

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Haji-Ghassemi, Omid. "Structural characterization of antibodies against lipopolysaccharide antigens: Insights into primary antibody response." Thesis, 2015. http://hdl.handle.net/1828/6012.

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Antibody combining sites are constructed from limited set of germ-line gene segments, yet are capable of both recognizing a broad range of common epitopes and eliciting an adaptive response to newly encountered pathogens. Carbohydrate antigens generally do not draw T cell help and concomitant affinity maturation in the humoral response. Therefore, anti-carbohydrate responses must rely more heavily on the primary germ-line gene repertoire. Antibodies are usually thought of as highly specific. It has been suggested that polyspecificity and cross-reactivity in germ-line antibodies is necessar

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Greenfield, Laura. "Biosynthesis of the lipopolysaccharide O-antigens of Escherichia coli serotypes O8 and O9a." Thesis, 2012. http://hdl.handle.net/10214/4040.

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The Escherichia coli O9a and O8 antigen serotypes represent model systems for the ABC transporter-dependent synthesis of bacterial polysaccharides. Their O-antigens are linear mannose homopolymers containing conserved reducing termini (the primer-adaptor), a variable repeat-unit domain, and a non-glycan terminator. Synthesis of these glycans occurs on the polyisoprenoid lipid acceptor, undecaprenyl pyrophosphoryl-β-GlcNAc, due to the sequential activities of two conserved mannosyltransferases, WbdC and WbdB, and a serotype-specific mannosyltransferase, WbdA. The work reported in this doctor

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Tsai, Yu-Chen, and 蔡雨蓁. "Characterization of The Biosynthesis Genes for Lipopolysaccharide Somatic Antigens of Pasteurella multocida and Application to Rapid-typing." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/05357364181630932708.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>98<br>Pasteurella multocida is the causative agent of many diseases in a wide range of domestic animals. Its lipopolysaccharide (LPS) somatic antigen is one of key virulence factors. Conventionally, P. multocida can be divided into 16 serotypes based on LPS somatic antigens by using the agar gel diffusion precipitation test (AGP). However, this method needs preparation of serotype-specific antisera, and takes few days to complete the work. To date, only a few of LPS structures and genome sequences for biosynthesis of LPS in P. multocida have been determined. In

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May, Kerrie Leanne. "Molecular characterisation of Shigella flexneri IcsA and the role of lipopolysaccharide O-antigen in actin-based motility." Thesis, 2007. http://hdl.handle.net/2440/95620.

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Shigella spp. cause bacillary dysentery through invasion of the colonic epithelium. Shigella flexneri IcsA (VirG) is a polarly localised, outer membrane (OM) protein that is essential for virulence. IcsA activates the host actin regulatory protein, neural Wiskott-Aldrich syndrome protein (N-WASP), which in-turn recruits the Arp2/3 complex that polymerises host actin. The resultant F-actin comet tails initiate bacterial actin-based motility (ABM) and intercellular spread. The N-terminal surface-exposed region of IcsA, referred to as the passenger domain (aa 53-758), is responsible for IcsA acti

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Hsu, Hao-Sheng, and 許豪陞. "Characterization and functional analyses of the biosynthesis genes for lipopolysaccharide somatic antigen of Avibacterium paragallinarum." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/23982100723887911054.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>101<br>Avibacterium paragallinarum is the causative agent of infectious coryza, an important respiratory disease associated with growth retardation and reduced egg production in chickens. Avibacterium paragallinarum is a gram-negative coccobacillus that possesses a variety of virulence factors, mostly associated with cell wall composition, and one of the factors is glycosylation. Expression of glycosylation enhances bacterial susceptibility to the complement-mediated killing by normal chicken serum. Genome sequencing analysis showed that Av. paragallinarum conta

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Masi, Andrea Patricia. "Production, characterization and application of a monoclonal antibody specific for Salmonella lipopolysaccharide O-9 antigen." 1995. http://hdl.handle.net/1993/18980.

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Wang, Heng-Yen, and 王姮雁. "Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/14697313672163571676.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>94<br>Chemical studies reveal that the structure of OPS are linear or branched among P. syringae strains. The linear backbone is composed of L-, D-, or both L-and D-rhamnose. The branch OPS is composed of linear backbone with homogenous or hetrogenous saccharide substitution. Above all, the pivot issue of this thesis is to synthesize the linear backbone motif of P. syringae, a trisaccharide structure of Rha(1→3) Rha(1→2)Rhap. Utilizing the anomeric center activation manner of imidate and manipulating all factors and condition during glycosylation, we accomplish th

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40

Nath, Pratiti. "Charaterisation [sic] of the Shigella flexneri O antigen polymerase Wzy." Thesis, 2015. http://hdl.handle.net/2440/101621.

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Shigella flexneri is the major causative agent of shigellosis that account for ~14000 deaths annually in Asia. The O antigen (Oag) component of S. flexneri lipopolysaccharide (LPS) is important for virulence and a protective antigen. It is synthesised by a Wzy-dependent mechanism. S. flexneri Wzy (Wzyᵴᵳ) has 12 transmembrane (TM) segments and two large periplasmic loops (PL). The modal chain length of the Oag is determined by chromosomally encoded Wzzᵴᵳ and pHS-2 plasmid encoded WzzpHS2 [pHS2 subscript]. Although Wzyᵴᵳ was identified 20 years ago, there is a lack of knowledge about its functio

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Lu, Mingfang. "Acyloxyacyl hydrolase : studies on its regulation and function in mus musculus." 2003. http://edissertations.library.swmed.edu/pdf/LuM120803/LuMingFang.pdf.

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Tram, Thi hong Nguyen, and 阮氏紅簪. "Studies on Helicobacter pylori 26695 proteins HP1581, HP1206, HP1039 involved in the O-antigen biosynthetic pathway and their effects on lipopolysaccharide biosynthesis and infection." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ud37d2.

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碩士<br>國立清華大學<br>分子醫學研究所<br>107<br>Helicobacter pylori is a spiral-shaped microaerophilic gram-negative bacterium and is recognized as a notorious human pathogen that infects a half of the world’s human population. Several human stomach diseases such as gastric ulcer, gastroduodenal ulcer, gastric adenocarcinoma and mucosa-associated lymphatic tissue (MALT) lymphoma are related with H. pylori infection. Lipopolysaccharide (LPS) is a major component on the surface of gram-negative bacteria including H. pylori and plays an important role in maintaining the integrity of bacterial outer membrane as

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Islam, Salim Timo. "Structural and Functional Characterization of O-Antigen Translocation and Polymerization in Pseudomonas aeruginosa PAO1." Thesis, 2013. http://hdl.handle.net/10214/7239.

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Heteropolymeric O antigen (O-Ag)-capped lipopolysaccharide is the principal constituent of the Gram-negative bacterial cell surface. It is assembled via the integral inner membrane (IM) Wzx/Wzy-dependent pathway. In Pseudomonas aeruginosa, Wzx translocates lipid-linked anionic O-Ag subunits from the cytoplasmic to the periplasmic leaflets of the IM, where Wzy polymerizes the subunits to lengths regulated by Wzz1/2. The Wzx and Wzy IM topologies were mapped using random C-terminal-truncation fusions to PhoALacZα, which displays PhoA/LacZ activity dependent upon its subcellular localization.

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