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Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Ozes, Ali Rayet. "Targeting the long non coding RNA HOTAIR in cancer." Thesis, Indiana University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10154781.

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<p> Ovarian cancer (OC) takes the lives of nearly 14,000 US women every year. Although platinum is one of the most effective drugs in treating ovarian cancer, the development of platinum resistance is one of the biggest challenges facing patients. I have shown that the long non-coding RNA HOTAIR contributes to platinum-resistant OC and determined the regulators and targets of HOTAIR during the platinum-induced DNA damage response. My published data supports the role of HOTAIR in contributing to DNA damage induced cellular senescence and secretion of pro-inflammatory cytokines leading to cispla

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Ard, Ryan Anthony. "Functional long non-coding RNA transcription in Schizosaccharomyces pombe." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20396.

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Eukaryotic genomes are pervasively transcribed and frequently generate long noncoding RNAs (lncRNAs). However, most lncRNAs remain uncharacterized. In this work, a set of positionally conserved intergenic lncRNAs in the fission yeast Schizosaccharomyces pombe genome are selected for further analysis. Deleting one of these lncRNA genes (ncRNA.1343) exhibited a clear phenotype: increased drug sensitivity. Further analyses revealed that deleting ncRNA.1343 also disrupted a previously unannotated lncRNA, termed nc-tgp1, transcribed in the opposite orientation of the predicted ncRNA.1343 gene and i

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Wijesinghe, Susanne. "Role of long non-coding RNA CCDC26 in gene regulation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8441/.

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LncRNAs are increasingly being recognised as functionally important for regulation of biological processes. We have identified an lncRNA which we believe is integral in lineage commitment during haematopoiesis. Here, we report that CCDC26 lncRNA is a regulator of β-globin and c-MYC gene expression. Indeed, CCDC26 silencing in erythroleukemic K562 cells led to several gene expression changes. Upon further investigation of genes linked to erythropoiesis, we observed the upregulation of β-globin expression. Our results suggest that CCDC26 regulates expression of β-globin and other genes by modula

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Ottway, Charlotte Jane. "Characterisation of Nespas, a non-coding imprinted RNA." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:b159c1e9-8d49-460c-a808-d920e8e17779.

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Nespas is the non-coding antisense transcript of the imprinted Gnas cluster; it is expressed from the paternal allele and is located on mouse distal chromosome 2. In this thesis new transcripts of >10 kb and 0.8 kb have been identified. The 0.8 kb transcript is a spliced variant that is retained in the nucleus and its 3’ end lies approximately 30 kb from the start site. Transcription from the Nespas promoter does not proceed beyond this point. A collection of previously known splice variants have also been detected and are exported to the cytoplasm. Nespas is expressed in the embryo during the

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Cabili, Nataly Moran. "Integrative Characterization of Human Long Non-Coding RNAs." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11409.

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Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the discovery of a new prevalent class of long non coding RNAs (lncRNAs). While these are lower abundant and relatively less conserved than other class of functional RNAs, lncRNAs are emerging as key players in different cellular processes in development and disease.

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Hammel, Alexander John. "Evolutionary conservation of long intergenic non-coding RNA genes in Arabidopsis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44974.

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Keniry, Andrew James. "H19 and miR-675 : a long noncoding RNA conceals a growth suppressing microRNA." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609990.

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Broadbent, Kate Mariel. "The regulatory capacity of long non-coding RNA in Plasmodium falciparum malaria." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065005.

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The mechanisms underpinning gene regulation in P. falciparum malaria remain largely elusive, though mounting evidence suggests a major role for epigenetic feedback. Interestingly, long non-(protein)-coding RNAs (lncRNAs) have been found to play a dominant role in initiating and guiding the transcriptional, epigenetic, and post-transcriptional status of specific loci across a broad range of organisms. LncRNAs are uniquely poised to act co-transcriptionally on neighboring loci, and/or to remain physically tethered at their site of origin, and through sequence-specific binding activities can impa

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Ballantyne, Margaret. "Understanding the role of long non-coding RNA (LncRNA) in vascular pathology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8101/.

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Coronary heart disease is a major cause of morbidity and mortality in the Western society. In the case of severe atherosclerosis, percutaneous intervention and coronary bypass grafting remain the preferred form of surgical treatment. However, the patency of both these treatments is limited and several bypass grafts and stents fail due to neointimal formation and in stent restenosis attributable to the proliferation of VSMCs. The resultant luminal renarrowing may manifest clinically with the return of symptoms such as chest pain or shortness of breath and ultimately requires further surgical in

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Pettini, Tom. "The role of novel long non-coding RNAs in Hox gene regulation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-novel-long-noncoding-rnas-in-hox-gene-regulation(c8e44900-3ac0-40be-8ec6-b50179381d17).html.

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Whole genome transcriptome analysis has revealed that a large proportion of the genome in higher metazoa is transcribed, yet only a small proportion of this transcription is protein-coding. One possible function of non-coding transcription is that it enables complex and diverse body plans to evolve through variation in deployment of a relatively common set of protein-coding genes. Functional studies suggest that long non-coding RNAs (lncRNAs) regulate gene expression via diverse mechanisms, operating in both cis and trans to activate or repress target genes. An emerging theme common to lncRNA

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11

Schmidt, Benjamin [Verfasser], and Thalia [Akademischer Betreuer] Erbes. "Untersuchungen zur Expression und potentiellen Biomarkerfunktion von long non-coding RNA beim Mammakarzinom." Freiburg : Universität, 2020. http://d-nb.info/1212361199/34.

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Yang, Junjie. "The role of H19, a long non-coding RNA in the immune system." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC206/document.

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L'empreinte génomique, une régulation épigénétique unique entraînant une expression génique spécifique aux parents d'origine, est essentielle au développement et à la croissance des mammifères. H19 est un ARN long non codant exprimé en milieu maternel qui est un régulateur central du réseau de gènes à empreinte contrôlant le développement. H19 est exprimé pendant le développement embryonnaire dans de nombreux tissus, y compris toutes les cellules hématopoïétiques. Le rôle de H19 au cours du développement embryonnaire n'a été documenté que pour le placenta où il contrôle la croissance. Le rôle

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13

Coyne, Victoria. "Characterization of long non-coding RNAs in the Hox complex of Drosophila." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/characterization-of-long-noncoding-rnas-in-the-hox-complex-of-drosophila(733e3dec-3f7b-4d6e-a1bc-674a8786246d).html.

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Long non-coding RNAs (lncRNAs) are often defined as transcripts >200nts that have no discernable protein-coding ability (Quinn and Chang, 2016). Although relatively little is understood about the molecular mechanisms of lncRNA function, they have established roles in regulation of gene expression during development, cell differentiation and pluripotency (Fatica and Bozzoni, 2014; Luo et al., 2016; Quinn and Chang, 2016; Rinn and Chang, 2012) across vastly diverse organisms ranging from plants to humans (Ulitsky and Bartel, 2013). LncRNAs have also been associated with numerous pathological con

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14

Haller, Alexandre. "Characterization of long non-coding RNA LENT, a potential therapeutic target in cutaneous melanoma." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ025.

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Le mélanome est le plus agressif des cancers de la peau, représentant 1 % des cancers cutanés mais responsable de la plupart des décès liés à ces cancers. Les mélanomes métastatiques sont traités par immunothérapie ou par une inhibition ciblée de MAPK. Néanmoins, la résistance primaire ou acquise met les chercheurs au défi de trouver de nouvelles thérapies. Dans ce contexte, le laboratoire d’accueil a identifié une série de longs ARNs non-codants (LncRNA) spécifiques du mélanome. Mon projet concerne le lncRNA LENT (LncRNA Enhancer of Translation) fortement exprimé dans les mélanomes par rappor

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15

MOROTTI, ANNAMARIA. "INSIGHTS INTO THE NON-CODING GENOME OF PARATHYROID TUMORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/610124.

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Recently, long non-coding RNAs (lncRNAs) have been implicated in the regulation of several physiological processes such as cell growth, differentiation and proliferation. Although lncRNAs functions in human diseases have not been completely disclosed, some lncRNAs have already been identified as prognostic and diagnostic biomarkers in different tumors. LncRNAs have also a crucial role in normal development of endocrine organs and their role in endocrine cancer pathogenesis is emerging. Parathyroid tumors are rare and heterogeneous diseases characterized by genetic and epigenetic alterations

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16

Karlsson, Joakim. "Differential and co-expression of long non-coding RNAs in abdominal aortic aneurysm." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236141.

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This project concerns an exploration of the presence and interactions of long non-coding RNA transcripts in an experimental atherosclerosis mouse model with relevance for human abdominal aortic aneurysm development. 187 long noncoding RNAs, two of them entirely novel, were found to be differentially expressed between angiotensin II treated (developing abdominal aortic aneurysms) and non-treated apolipoprotein E deficient mice (not developing aneurysms) harvested after the same period of time. These transcripts were also studied with regards to co-expression network connections. Eleven previous

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NESREEN, HAMAD ABDELGAWWAD HAMAD. "Structural analysis of the interaction between FUS/TLS protein and non-coding RNA." Kyoto University, 2020. http://hdl.handle.net/2433/259065.

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Niemczyk, Malwina. "Epigenetic and transcriptional relationship between a novel long non-coding RNA GNG12-AS1 and imprinted DIRAS3." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708234.

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Ahmadov, Ulvi [Verfasser]. "The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma / Ulvi Ahmadov." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1222736969/34.

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VINCI, CRISTINA. "THE RELEVANCE OF LONG NON-CODING RNA IN THE BIOLOGICAL AND CLINICAL HETEROGENEITY OF MULTIPLE MYELOMA." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/615064.

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Il mieloma multiplo (MM) è una proliferazione maligna di plasmacellule del midollo osseo secernenti anticorpi, che rappresenta il 10% di tutte le neoplasie ematologiche. Il MM è caratterizzato da un ampio spettro clinico che va da una presunta condizione pre-maligna chiamata gammopatia monoclonale di significato indeterminato a mieloma extra-midollare/ leucemia plasmacellulare (PCL). Nonostante i notevoli miglioramenti nel trattamento e nella cura dei pazienti, il MM è ancora una patologia incurabile. Negli ultimi anni è stato dimostrato che la stragrande maggioranza (> 90%) della sequenza de

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Bussotti, Giovanni 1983. "Detecting and comparing non-coding RNAs." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/128970.

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In recent years there has been a growing interest in the field of non-coding RNA. This surge is a direct consequence of the discovery of a huge number of new non-coding genes, and of the finding that many of these transcripts are involved in key cellular functions. In this context, accurately detecting and comparing RNA sequences becomes extremely important. Aligning nucleotide sequences is one of the main requisite when searching for homologous genes. Accurate alignments reveal evolutionary relationships, conserved regions and more generally, any biologically relevant pattern. Comparing RNA m

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22

Zhang, Zhouwei. "Investigation of DNA and RNA markers by novel technologies demonstrates DNA content intratumoral heterogeneity and long non-coding RNA aberrations in breast tumors." ScholarWorks @ UVM, 2014. https://scholarworks.uvm.edu/graddis/323.

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BACKGROUND: Breast cancer is the most commonly diagnosed cancer and second leading cancer death cause among females in the U.S.A. About 1 in 8 women in U.S will develop invasive breast cancer over the course of her lifetime. In 2013, 234,580 new invasive breast cancer cases are expected to occur in women within the US and approximately 64,640 non-invasive carcinomas in situ were diagnosed in 2013, most of which were ductal carcinoma in situ (DCIS). Along with technological advances, a wide variety of candidate biomarkers have been proposed for cancer diagnosis and prognosis, including DNA cont

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23

Floriot, Océane. "Virus de l’Hépatite B et transcription cellulaire : impact de la protéine HBx et de ses interactions avec les ARNs non-codants." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1319/document.

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Le virus de l'hépatite B (VHB) reste un problème de santé majeur dans le monde malgré la disponibilité du vaccin. Le VHB n’est pas éradiqué par les thérapies actuelles et 240 millions de personnes infectées chroniquement restent à risque de développer une cirrhose du foie et un carcinome hépatocellulaire (CHC).Le VHB est un petit virus hépatotrope doté d'un génome à ADN double brin partiel (ADNrc). Après infection l'ADNrc est converti en ADN épisomal (ADNccc) qui est ensuite organisé en minichromosome viral, qui est le modèle pour la transcription et qui initie la réplication. La protéine de l

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Nowicki-Osuch, Karol Piotr. "Identification and characterisation of long non-coding RNAs expressed downstream of EGF-induced signalling programme." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/identification-and-characterisation-of-long-noncoding-rnas-expressed-downstream-of-egfinduced-signalling-programme(fd52d235-1a50-4347-bdb1-fdba4fdb912d).html.

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It has recently become apparent that cells encode a large number of novel non-protein-coding genes called long non-coding RNAs (lncRNAs). Whilst the biological function of many lncRNAs remains unknown, recent evidence has suggested that lncRNAs may be important regulators of cellular growth, differentiation and may play a significant role in cancer. Epidermal growth factor (EGF) – an activator of the ERK1/2 signalling cascade – is an important spatio-temporal regulator of transcription and, ultimately, of cellular growth and movement. EGF stimulation triggers a wave-like expression of immediat

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Xie, Bingning. "Long non-coding RNA-based mechanisms for the inhibition of cell growth and development by 5 - Fluorouracil." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B046/document.

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Les ARNm codent pour les protéines, tandis qu'un grand nombre d'ARNs nommés longues ARNs non codants (ARNlnc) ne sont pas traduites en protéines. Les deux types d’ARNs existent en isoforms qui se distinguent à cause de l’épissage alternatif. Certains des ARNlnc jouent des rôles importants dans la croissance et différentiation cellulaire. Cependant, leurs fonctions dans la cytotoxicité de la chimiothérapie anti-cancéreuse médicamenteuse utilisant le 5-fluorouracile (5-FU) sont encore inconnues. Pendant mes travaux j'ai trouvé que le traitement par le 5-FU cause l’accumulation des ARNlnc. Ce phé

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Gandhi, Minakshi [Verfasser], and Peter [Akademischer Betreuer] Angel. "Role of long non-coding RNA lincNMR in nucleotide metabolism in cancer / Minakshi Gandhi ; Betreuer: Peter Angel." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1195143826/34.

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Musahl, Anne-Susann [Verfasser]. "Transcriptional characterization and functional analysis of long non-coding RNA/protein-coding gene pairs encoded in the human genome / Anne-Susann Musahl." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1075493706/34.

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Cimatti, Laura. "Long Non-Coding RNA Antisense to Uchl1 Increases Its Protein Translation and Identifies a New Class of Protein Translation Activators." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/3922.

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Thanks to continuous technical advances in the sequencing field nowadays we know that most of the mammalian genome is transcribed. This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs) and repetitive sequences, such as Short Interspersed Nuclear Elements (SINEs). A large percentage of ncRNAs is nuclear-enriched with unknown function. LncRNAs may be transcribed in antisense direction and may form sense/antisense pairs by pairing with an mRNA from the opposite strand to regulate chromatin conformation, transcription an

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Uroda, Tina. "Caractérisation structurale et fonctionnelle de l’ARN long non codant MEG3." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV014.

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Les ARNs long non codants (ARNlnc) jouent un rôle clé dans les processus cellulaires vitaux, notamment le remodelage de la chromatine, la réparation de l'ADN et la traduction. Cependant, la taille et la complexité des ARNlnc présentent des défis sans précédent pour les études moléculaires mécanistiques, de sorte qu'il s'est avéré difficile jusqu'à présent de relier l'information structurelle à la fonction biologique pour les ARNlnc.Le gène 3 humain exprimé maternellement (de l’anglais "maternally expressed gene 3", MEG3), est un ARNlnc abondant, soumis à empreinte parentale et épissé alternati

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Furió, Tarí Pedro. "Development of bioinformatic tools for massive sequencing analysis." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/152485.

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[EN] Transcriptomics is one of the most important and relevant areas of bioinformatics. It allows detecting the genes that are expressed at a particular moment in time to explore the relation between genotype and phenotype. Transcriptomic analysis has been historically performed using microarrays until 2008 when high-throughput RNA sequencing (RNA-Seq) was launched on the market, replacing the old technique. However, despite the clear advantages over microarrays, it was necessary to understand factors such as the quality of the data, reproducibility and replicability of the analyses and potent

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Zhang, Shaoyan. "Overexpression of the Turnip Crinkle Virus Replicase Exerts Opposite Effects on the Synthesis of Viral Genomic RNA and a Novel Viral Long Non-Coding RNA." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595258672390499.

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Dumbović, Gabrijela 1986. "Molecular and mechanistic characterization of a novel long non-coding RNA derived from NBL2 macrosatellite repeats in colorectal cancer." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/523517.

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DNA hypomethylation of repeats has been found in almost every tumor type studied. Hypomethylation of repetitive elements was shown to increase the likelihood of homologous recombination of these repeated sequences and thus contribute to genome instability. In our group we have found a macrosatellite repeat called NBL2 hypomethylated in a subset of colorectal cancers (CRCs). NBL2 somatic hypomethylation in CRC associated with genomic damage, especially in tumors having wild type P53. Here, we describe the genomic location of NBL2 by thorough in silico analysis, metaphase FISH and PCR on DNA fr

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Barcelos, Rafael Mazioli. "Is Rickettsia amblyommii able to regulate long non-coding RNA expression in Amblyomma sculptum tick? An in silico approach." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/12399.

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Submitted by Nathália Faria da Silva (nathaliafsilva.ufv@gmail.com) on 2017-10-25T17:11:15Z No. of bitstreams: 1 texto completo.pdf: 1261921 bytes, checksum: 067fce7911dd12871ca7da328ba82529 (MD5)<br>Made available in DSpace on 2017-10-25T17:11:15Z (GMT). No. of bitstreams: 1 texto completo.pdf: 1261921 bytes, checksum: 067fce7911dd12871ca7da328ba82529 (MD5) Previous issue date: 2017-06-28<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>O carrapato Amblyomma sculptum pertence ao complexo Amblyomma cajennnense, taxon mais importante na transmissão e como hospedeiro da ba

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GIAGNORIO, ELEONORA. "Revealing the involvement of MALAT1, NEAT1, HOTTIP lncRNAs in Amyotrophic Lateral Sclerosis (ALS) via an induced pluripotent stem cell (iPSC)-derived muscle cell model." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/385034.

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La SLA è una malattia neurodegenerativa caratterizzata da una progressiva degenerazione dei MN, con conseguente atrofia muscolare, paralisi e morte del paziente. Esistono due forme di SLA, la forma sporadica, nel 90% dei pazienti, e la forma familiare, nel restante 10% dei casi. Diversi geni sono associati alla SLA, come C9ORF72 che è il gene più comunemente associato alla forma familiare di SLA, seguito da TARDBP, SOD1 e FUS. Questi geni influiscono su diverse funzioni cellulari, tra cui lo stress ossidativo, il metabolismo dell’RNA, l’organizzazione del citoscheletro e l’autofagia. I geni as

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Sukubo, N. G. "NO CODING RNAs IN MACROPHAGE POLARIZATION: THE RELEVANCE OF THE "JUNK" RNA." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365870.

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Abstract Form the central dogma of the biology formulated by Crick in 1958, to the detection of “junk RNA”, a new prospective has been open. Macrophages are essential cell of the innate immunity system important in onset and resolve inflammation. Moreover they are important in the cross-talk with adaptive immunology. It is also clear that macrophages are involved in many chronic diseases such as atherosclerosis, asthma, rheumatoid arthritis. In these pathologies there is an anomalous prolongation/amplification of the macrophage challenge to lead homeostasis. In this landscape favor macrophage

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Moreno, Leon Laura. "Étude d'un long ARN non codant induit par l'hypoxie et associé à l’agressivité des adénocarcinomes bronchopulmonaires." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4144.

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Les cancers bronchopulmonaires non à petites cellules (CBNPC) sont la première cause de décès par cancer, les adénocarcinomes étant la forme la plus fréquente. Malgré une prise en charge précoce, ils constituent, par leur taux de récidive important et leur mauvais pronostic, un véritable problème de santé publique. Nous nous intéressons à l'hypoxie, un facteur agressivité des ADC, et à la famille des longs ARNs non codants (lncARNs), dérégulés dans de nombreux cancers et en réponse à l'hypoxie, mais peu caractérisés sur le plan structural et fonctionnel. Ces transcrits représentent un espoir p

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Surappa-Narayanappa, Ananth Prakash. "The evolution, modifications and interactions of proteins and RNAs." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269851.

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Proteins and RNAs are two of the most versatile macromolecules that carry out almost all functions within living organisms. In this thesis I have explored evolutionary and regulatory aspects of proteins and RNAs by studying their structures, modifications and interactions. In the first chapter of my thesis I investigate domain atrophy, a term I coined to describe large-scale deletions of core structural elements within protein domains. By looking into truncated domain boundaries across several domain families using Pfam, I was able to identify rare cases of domains that showed atrophy. Given t

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Furlan, Giulia. "Investigating the contribution of the non-coding gene Ftx to X-chromosome inactivation in mammals." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC191/document.

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L’inactivation du chromosome X (XCI) est un mécanisme qui permet l’extinction transcriptionelle d’un des deux chromosomes X chez la femelle. XCI est régulé par une région spécifique nommée centre de l’inactivation du chromosome (Xic), contenant plusieurs gènes produisant de longs ARNs non codants (lncRNAs). Parmi ces lncRNAs, le transcrit Xist est l’effecteur principal pour l’XCI. Xist peut s’accumuler en cis sur le chromosome et recruter la machinerie qui permettra l’initiation et la propagation de l’extinction transcriptionnelle à l’échelle du chromosome.Le laboratoire d’accueil a identifié

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Chehade, Marthe. "Thre Long Noncoding RNA PRINS in Endocrine Cancer: Evaluating its Clinical Significance and the Evidence for its Functional Role." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29641.

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Adrenocortical carcinoma (ACC) and breast cancer are endocrine malignancies with poor prognosis in advanced disease. Long non-coding RNA (lncRNA) have varied roles in the regulation of gene expression and can act as oncogenes and tumour suppressors. Psoriasis-susceptibility associated RNA gene induced by stress (PRINS) is a lncRNA that is under-expressed in ACC tissues in a tumour suppressor pattern and predicts disease recurrence. This thesis aims to evaluate the potential of PRINS as a tumour suppressor in various ACC and breast cancer in-vitro gain-of-function (GoF) models, and explore t

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David, Antoine. "Rôle du long ARN non-codant CRNDE dans le myélome multiple." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7104.

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En dépit des avancées thérapeutiques récentes, le MM reste à ce jour une maladie incurable, dont les voies moléculaires impliquées dans l’hétérogénéité clinique, la progression, et l’agressivité du MM restent encore relativement peu connues. Au cours de cette dernière décennie, le rôle des lncRNAs a été de plus en plus étudié. En effet, les données génomiques, les études globales d’expression spatio-temporelle et l’existence de plusieurs lncRNAs démontrés comme impliqués dans différentes voies physiologiques suggèrent que les lncRNAs sont des régulateurs transcriptionnels et post-transcription

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Rontani, Pauline. "Caractérisation du long ARN non codant COSMOC dérégulé dans les troubles du spectre autistique : une approche transcriptomique sur cellules souches olfactives humaines." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0770.

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L’autisme est un syndrome neuro-développemental hétérogène à l’étiologie génétique complexe. Afin d’identifier les dérèglements initiaux responsables de ce mal-développement cérébral, des travaux antérieurs au sein de notre équipe se sont basés sur des cellules représentatives des stades précoces de l’ontogenèse : les cellules souches olfactives. Le gène MOCOS, codant pour la sulfurase du cofacteur à molybdène, a été trouvée sous-exprimé chez la majorité des patients autistes comparés à des sujets contrôles de même âge et du même sexe.Nous avons ensuite postulé que la dissection minutieuse des

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Horn, Jessica [Verfasser], Thomas [Gutachter] Rudel, and Cynthia [Gutachter] Sharma. "Molecular and functional characterization of the long non-coding RNA SSR42 in \(Staphylococcus\) \(aureus\) / Jessica Horn ; Gutachter: Thomas Rudel, Cynthia Sharma." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1176972960/34.

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Trembinski, Dorotée Julia [Verfasser], Stefanie [Akademischer Betreuer] Dimmeler, Stefanie [Gutachter] Dimmeler, and Michaela [Gutachter] Müller-McNicoll. "Long non-coding RNA sarrah: Staying young at heart / Dorotée Julia Trembinski ; Gutachter: Stefanie Dimmeler, Michaela Müller-McNicoll ; Betreuer: Stefanie Dimmeler." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2019. http://d-nb.info/1202297943/34.

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CAO, YU. "Role of lncRNA in cancer development and progression." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1429.

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PART1, TITLE: A p53-inducible long non-coding RNA PICART1 mediating cancer cell proliferation and migration. Long non-coding RNAs (lncRNAs) function in the development and progression of cancer, but only a small portion of lncRNAs are characterized thus far. A novel lncRNA transcript with 2.53 kb in length was identified by a transcriptome sequencing analysis, named p53-inducible cancer-associated RNA transcript 1 (PICART1). This PICART1 is upregulated by p53 through a p53-binding site at -1808 to -1783bp. In breast and colorectal cancer cells and tissues, PICART1 expression was decreased. Ect

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Oldoni, E. "THE ROLE OF CELLULAR AND EXOSOMAL NEURAL-DERIVED LONG NON CODING RNA (LNCRNA) IN MULTIPLE SCLEROSIS: POTENTIAL BIOMARKERS OF DISEASE SUSCEPTIBILITY AND PROGRESSION." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/540356.

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Long non-coding RNAs (lncRNAs) are a novel class of transcripts that are pervasively transcribed in the genome. Several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological and autoimmune disorders, but their expression has not been exhaustively investigated in MS so far. The main aim of this study was to identify a specific signature of cellular and neural-derived exosomal lncRNA expression. Regarding lncRNA expression levels from Peripheral Blood Mononuclear Cells (PBMC), we studied a discovery cohort of MS patients who were compared agai

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Blank-Giwojna, Alena [Verfasser], and Ingrid [Akademischer Betreuer] Grummt. "Long non-coding RNA KHPS1 drives a regulatory cascade which activates expression of the protooncogene SPHK1 / Alena Blank-Giwojna ; Betreuer: Ingrid Grummt." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1201414059/34.

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Leroy, Estelle. "Study of non-coding RNAs in the control of fission yeast gametogenesis." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASL014.

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Largement répandus dans les génomes eucaryotes, les longs ARN non codants (lncRNAs) jouent un rôle clef dans l'identité cellulaire et diverses pathologies humaines, telles que les troubles développementaux et les cancers. Ils régulent l'expression des gènes et l'intégrité du génome en agissant comme guides (ciblant des protéines à un locus génomique), échafaudages (pontant des protéines) ou éponges (titrant des protéines ou autres ARN). Ils s'associent également avec diverses protéines partenaires, formant ainsi des complexes ribonucléoprotéiques (lncRNPs). Conservée dans les espèces à reprod

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Moreno, Leon Laura. "Étude d'un long ARN non codant induit par l'hypoxie et associé à l’agressivité des adénocarcinomes bronchopulmonaires." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4144.

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Les cancers bronchopulmonaires non à petites cellules (CBNPC) sont la première cause de décès par cancer, les adénocarcinomes étant la forme la plus fréquente. Malgré une prise en charge précoce, ils constituent, par leur taux de récidive important et leur mauvais pronostic, un véritable problème de santé publique. Nous nous intéressons à l'hypoxie, un facteur agressivité des ADC, et à la famille des longs ARNs non codants (lncARNs), dérégulés dans de nombreux cancers et en réponse à l'hypoxie, mais peu caractérisés sur le plan structural et fonctionnel. Ces transcrits représentent un espoir p

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Smith, Jenna E. "Investigation of the mRNP and Transcriptome Regulated by Nonsense-Mediated RNA Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1421428941.

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Bernard, Laure. "Regulation of heterochromatin by a pluripotency-associated long non coding RNA in mouse embryonic stem cells and in oocytes : implications for early embryogenesis." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS179.

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La méthylation de l'histone H3 Lysine 9 (H3K9me) est une marque de l'hétérochromatine progressivement déposée au cours du développement. Elle contribue à la restriction de certains destins cellulaires. Dans les cellules souches embryonnaires de souris (mESCs), les niveaux de H3K9me augmentent lors de la différentiation, constituant alors une barrière à la reprogrammation à l'état pluripotent. Cependant le couplage entre les niveaux d'H3K9me et la pluripotence n'a encore jamais été formellement étudié. On a ainsi identifié SUV39H1, une methyltransferase responsable de la propagation di/tri H3K9

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