Gotowe bibliografie tematyczne / Pulsatile drug delivery system

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  1. Artykuły w czasopismach
  2. Rozprawy doktorskie
  3. Książki
  4. Części książek
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Gotowa bibliografia na temat „Pulsatile drug delivery system”

Autor: Grafiati
Data publikacji: 2 czerwca 2025
Data aktualizacji: 5 lipca 2025

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Artykuły w czasopismach na temat "Pulsatile drug delivery system"

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Sharma, Abhimanyu Rai, Binu Raina, Prabhjot Singh Bajwa, Anurag Bhargava, Toshiba Toshiba, and Vrinda Goel. "Pulsatile Drug Delivery System-A Review." Asian Pacific Journal of Health Sciences 5, no. 3 (2018): 260–70. http://dx.doi.org/10.21276/apjhs.2018.5.3.38.

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Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. A popular class of single-pulse systems is that of rupturable dosage forms. Other systems consist of a drug-containing core, covered by a swelling layer and an outer insoluble, but semipermeable polymer coating or membrane. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc.
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Belgamwar, VeenaS, MadhuriV Gaikwad, GaneshB Patil, and Sanjay Surana. "Pulsatile drug delivery system." Asian Journal of Pharmaceutics 2, no. 3 (2008): 141. http://dx.doi.org/10.4103/0973-8398.43297.

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SHARMA, PRASHANT. "Pulsatile Drug Delivery System – A Novel Approach for Time and Spatial Controlled Drug Delivery." Journal of Pharmaceutical Technology, Research and Management 4, no. 1 (2016): 13–29. http://dx.doi.org/10.15415/jptrm.2016.41002.

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Kapila, Arpita* Rambabu Sharma Agarwal Shweta. "PULSATILE DRUG DELIVERY SYSTEM: A MECHANISTIC UPDATE." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 3928–34. https://doi.org/10.5281/zenodo.1042593.

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Pulsatile drug delivery systems are the systems which deliver the drug according to the circadian rhythm of the body. The product follows a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus, these systems deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are available in the market. Chronotherapeutics have been used for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypotension, ulcer, hypercholesterolemia etc. These are beneficial for diseases showing chronopharmacological behaviour where night time dosing is required and for drugs having high first pass effect or having site specific absorption in gastrointestinal tract or drugs having high risk of toxicity or tolerance. Keywords: Pulsatile, circadian rhythm, chronotherapeutics, hypercholesterolemia, chronopharmacological behaviour.
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Garg, Tarun. "PULSATILE DRUG DELIVERY SYSTEMS: PULSINCAP SYSTEM." IOSR Journal of Pharmacy (IOSRPHR) 2, no. 2 (2012): 338–39. http://dx.doi.org/10.9790/3013-0220338339.

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Shelke Amruta P, Wagh Priti A, Nikam Sakshi M, and Bhosale Jaydeep J. "Pulsatile drug delivery system: A review." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 457–66. https://doi.org/10.30574/wjbphs.2025.21.2.0187.

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Pulsatile Drug Delivery Systems (PDDS) are increasingly recognized for their ability to deliver drugs at specific times, tailored to the pathophysiological needs of a disease. This approach enhances therapeutic efficacy and patient compliance. The core concept of PDDS involves a defined lag-time before a rapid drug release, which can be particularly beneficial for treatments requiring synchronization with the body’s natural circadian rhythms. By aligning peak plasma concentrations with these biological cycles, PDDS can improve both the safety and effectiveness of drugs over a 24-hour period. There are various techniques for achieving pulsatile drug release, including pH-dependent and time-dependent systems. These systems are generally classified into multiple-pulse and single-pulse categories. A common example of a single-pulse system is the rupturable dosage form, which releases the drug in one rapid dose after the lag-time. PDDS offer several advantages, including reduced dosing frequency, minimized side effects, and the potential for targeted drug delivery to specific sites such as the colon. Several innovative PDDS technologies, including Pulsincap and Diffucaps, have been developed and launched by pharmaceutical companies, further expanding the applications of pulsatile release and improving patient outcomes.
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Albadri, Ahmed A., Mustafa R. Abdulbaqi, and Yasir Q. Almajidi. "Recent Trends in Chronopharmaceutics, Pulsatile Drug Delivery System." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 4 (2019): 41–49. http://dx.doi.org/10.32947/ajps.v19i4.631.

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Pulsatile Drug Delivery Systems (PDDS) are getting considerable interest in delivering a drug at the correct position, at the correct time, and in the correct quantity, thus offering temporal, spatial, and intelligent delivery with improving patient compliance. These systems are
 
 intended to meet body's biological rhythm. Here, the delivery of drugs is assisted by the rhythm of disease. The main reason for the using pulsatile drug release is when the continuous drug release is not required. A PDDS must be designed in such a way that after the lag time a complete and fast release of drugs is achieved. The article deals with various systems such as osmotic system, capsular system, single and multi-unit system based on the utilization of erodible or soluble polymer coating and using of rupturable membrane. These systems are favorable to drugs with chronopharmacological behaviors such as drugs used to treat rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. The current review paper focus on the causes for pulsatile drug delivery system design, types of illness requiring pulsatile release, classification, benefits, and restriction of this drug delivery system.
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D., K. Singh, Poddar A.S., Nigade S.U., and S. Poddar S. "Pulsatile Drug Delivery System: An Overview." International Journal of Current Pharmaceutical Review and Research 2, no. 2 (2011): 55–80. https://doi.org/10.5281/zenodo.12698485.

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Pulsatile drug delivery systems (PDDS) are gaining importance as they deliver a drug atspecific time as per the pathophysiological need of the disease, resulting in improvedtherapeutic efficacy as well as compliance. Diseases wherein PDDS are promising includeasthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children,and hypercholesterolemia. These delivery systems can be classified into time controlledwherein the drug release is governed primarily by the delivery system; stimuli induced inwhich release is controlled by a stimuli, like the pH or enzymes present in the intestinal tractor enzymes present in the drug delivery system and externally regulated system where releaseis programmed by external stimuli like magnetism, ultrasound, electrical effect andirradiation. The current article focuses on the review of literature concerning the diseaserequiring PDDS, methodologies involved in the existing systems, recent update and productcurrently available in the market. 
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Hussein, Mayssam, and Israa Nathir. "Pulsatile Drug Delivery System Utilizing Innovative Technology." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 601–6. http://dx.doi.org/10.53350/pjmhs22166601.

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Drugs might be released immediately or over time. Pulsatile medication release systems, on the other hand, have been increasing in popularity in recent years. Many medications or therapies could benefit from pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. Pulsatile release systems come in pairs: multi and separate pulse. Rupturable dose forms are a prominent type of single-pulse device. Other methods have a drug-containing centre covered by both a swelling surface and a semi - permeable barrier polymer layer or membrane that is semipermeable but not soluble. The full action of the swelling film, and the permeability and mechanical qualities of the polymer covering, have a large impact in the lag time before the rupture. Many significant features in living organisms are controlled either by pulse or temporary release of active ingredients at a particular spot and duration. As a result, innovative drug delivery systems must be created to accomplish pulsed dispersion of a specified quantity of drugs in simulating the action of organisms while reducing adverse reactions. Special emphasis has been paid to the thermolabile poly (N-isopropylacrylamide) and its derivatives hydrogels. Designing drug delivery devices, hydrogels, and other materials. Micelles allows for thermal stimuli-regulated pulsed drug release. So, pulsatile medication delivery is one of those systems that has a lot of promise for people with long-term conditions like arthritis, asthma, and high blood pressure because it gives drugs at the right time, in the right place, and in the right amount. Keywords: Pulsatile release of drug, chronotherapy, circadian, and time lag
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Rozprawy doktorskie na temat "Pulsatile drug delivery system"

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Kwok, Connie Sau-Kuen. "Development of self-assembled molecular structures on polymeric surfaces and their applications as ultrasonically responsive barrier coatings for on-demand, pulsatile drug delivery /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7999.

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Gandhi, Swapnilkumar J. "Barrier-mediated pulsatile release." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1601.

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Solutes are often most efficiently deployed in discrete pulses, for example in the delivery of herbicides or drugs. Manual application of each pulse can be labor-intensive, automated application of each pulse can be capital intensive, and both are often costly and impractical. Barrier-Mediated Pulsatile Release (BMPR) systems offer a materials-based alternative for automated pulsatile drug delivery, without pumps, power supplies, or complex circuitry. While earlier materials-based approaches such as delayed-release microcapsules are limited to two or three pulses due to the independent nature of each pulse’s timing control, BMPR systems link the timing of each pulse to the previous pulse. Each dose of drug is sequestered in its own stimuli-sensitive depot, releasing only upon contact with the stimulant. These depots are stacked with sacrificial barriers in between, each of which block the stimulant for a predetermined time. For instance, layers of soluble drug may be separated by degradable polymer layers. Water, as the stimulant, will erode the polymer layer over a fixed period of time, followed by quick dissolution and release of the underlying drug and the start of degradation for the next polymer layer. This example, however, is quickly limited by irregular polymer erosion, a single stimulant (water), and difficulty in scaling delay times. The research work presented in this thesis reports the development of a generalized BMPR system which overcomes those limitations. Model drugs (methylene blue and methyl orange) were immobilized in a pH-sensitive polymer [poly(methyl methacrylate-co-dimethylaminoethyl methacrylate)] which released only at low pH. Zinc oxide (ZnO) nanoparticles immobilized in a pH-insensitive matrix [poly(vinyl alcohol)] served as the barrier layer. The time required for acid to penetrate the barrier layer scaled with the ZnO concentration and with the square of the polymer thickness, allowing wide scaling of the delay time with only minor changes to the barrier layer. Harnessing the swelling pressure of the acid-sensitive hydrogel, each barrier/depot bilayer can delaminate upon solute release, directly exposing the next bilayer to the stimulant source. This system has demonstrated tuned release using a citric acid stimulant to produce up to ten pulses of model drug (methylene blue) over various preset timescales. This system has also demonstrated the alternate release of multiple solutes (methylene blue and methyl orange) at regular time intervals up to five pulses from a single BMPR device. For non-delaminating BMPR systems, spent bilayers impede stimulant diffusion to the inner layers and solute diffusion from the inner layers, increasing the delay time and the pulse width. To predict these changes, a computational model was constructed in FORTRAN. This model was extensively explored over a wide range of parameter space to understand the release behavior of various kinds of non-delaminating BMPR systems. The computer model also validates the performances of experimental delaminating BMPR system. This model can be used to guide the physical modeling of BMPR systems. The model also allows to incorporate variety of stimulants other than just acid. BMPR technology introduces efforts to further generalize the delivery strategy by incorporating glucose as a stimulant.
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Berton, Damiano <1994&gt. "Microfluidic production of drug delivery system." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19484.

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Leach, Jeffrey Harold. "Magnetic Targeted Drug Delivery." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/31261.

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Methods of guiding magnetic particles in a controlled fashion through the arterial system in vivo using external magnetic fields are explored. Included are discussions of applications, magnetic field properties needed to allow guiding based on particle characteristics, hemodynamic forces, the uniformity of field and gradients, variable tissue characteristics, and imaging techniques employed to view these particles while in transport. These factors influence the type of magnetic guidance system that is needed for an effective drug delivery system. This thesis reviews past magnetic drug delivery work, variables, and concepts that needed to be understood for the development of an in vivo magnetic drug delivery system. The results of this thesis are the concise study and review of present methods for guided magnetic particles, aggregate theoretical work to allow proper hypotheses and extrapolations to be made, and experimental applications of these hypotheses to a working magnetic guidance system. The design and characterization of a magnetic guidance system was discussed and built. The restraint for this system that balanced multiple competing variables was primarily an active volume of 0.64 cm3, a workspace clearance of at least an inch on every side, a field of 0.3T, and a local axial gradient of 13 T/m. 3D electromagnetic finite element analysis modeling was performed and compared with experimental results. Drug delivery vehicles, a series of magnetic seeds, were successfully characterized using a vibrating sample magnetometer. Next, the magnetic seed was investigated under various flow conditions in vitro to analyze the effectiveness of the drug delivery system. Finally, the drug delivery system was successfully demonstrated under limiting assumptions of a specific magnetic field and gradient, seed material, a low fluid flow, and a small volume.<br>Master of Science
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Ho, Duc Hong Linh 1978. "Packaging for a drug delivery microelectromechanical system." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/30262.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005.<br>Includes bibliographical references (p. 52-55).<br>Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. A silicon microelectromechanical drug delivery device was fabricated for the purpose of delivering chemotherapeutic agents such-as carmustine, a potent brain cancer drug, directly to the site of the tumor. Limitations in the delivery capacity of the device led to the design of a new package. This package is made from thermally bonded Pyrex® 7740 frames that are anodically bonded to the drug delivery chip. It increases the capacity of the chip, is smaller than the previous package and possesses true hermeticity, because of the bonding processes involved. This work describes the fabrication steps of the new package and a problem with the thermal bonding of Pyrex® frames preventing the achievement of a package true to the original design. A temporary solution was devised and the completed package was tested with regards to its intended goals. It managed to increase the load capacity of the chip by a, factor of 10, with potential for more, while decreasing the overall size of the package. Short-term hermeticity was achieved for this package by using a UV-cured epoxy to bond some pieces, which was not in the original design. Future work will focus on finding a permanent solution to the aforementioned problem, and directions for it were suggested.<br>by Hong Linh Ho Duc.<br>S.M.
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Dyer, Robert J. (Robert Joseph) 1977. "Needle-less injection system for drug delivery." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/89388.

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Bright, Anne M. "Towards an improved ocular drug delivery system." Thesis, Aston University, 1992. http://publications.aston.ac.uk/9801/.

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The ultimate aim of this project was to design new biomaterials which will improve the efficiency of ocular drug delivery systems. Initially, it was necessary to review the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the literature that the ocular glycoprotein, mucin, plays an important role in tear film stability, and furthermore, that it exists as an adherent layer covering the corneal surface. If this belief is true, the muco-corneal interaction provides the ideal basis for the development of sustained release drug delivery. Preliminary investigations were made to assess the ability of mucin to adhere to polymer surfaces. The intention was to develop a synthetic model which would mimic the supposed corneal/mucin interaction. Analytical procedures included the use of microscopy (phase contrast and fluorescence), fluorophotometry, and mucin-staining dyes. Additionally, the physical properties of tears and tear models were assessed under conditions mimicking those of the preocular environment, using rheological and tensiometric techniques. The wetting abilities of these tear models and opthalmic formulations were also investigated. Tissue culture techniques were employed to enable the surface properties of the corneal surface to be studied by means of cultured corneal cells. The results of these investigations enabled the calculation of interfacial and surface characteristics of tears, tear models, and the corneal surface. Over all, this work cast doubt on the accepted relationship of mucin with the cornea. A corneal surface model was designed, on the basis of the information obtained during this project, which would possess similar surface chemical properties (i.e. would be biomimetic) to the more complex original. This model, together with the information gained on the properties of tears and solutions intended for ocular instillation, could be valuable in the design of drug formulations with enhanced ocular retention times. Furthermore, the model itself may form the basis for the design of an effective drug-carrier.
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Birudaraj, Kondamraj. "Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/2733.

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The objective of this research was to investigate two important aspects of buccal drug delivery, transport and mucoadhesion. Buspirone was chosen as a model drug for the in vitro buccal transport studies, polyvinyl alcohol and sodium alginate polymer blends were prepared to investigate the mucoadhesive properties through a Lewis acid-base approach and finally, the effect of formulation factors on the force of mucoadhesion, surface energy parameters, release rate and flux was studied. In vitro permeation studies were conducted to investigate the buccal transport pathway of buspirone. Mathematical models were developed to quantify the process of permeation. Permeation enhancement of buspirone across the buccal mucosa was investigated using bile salts (sodium glycocholate and taurodeoxycholate), propylene glycol, propylene. Effect of formulation factors like drug, enhancer, and plasticizer was studied through statistically designed experiments. These experiments aided in characterizing the buccal delivery system. Mathematical models were developed for surface energy parameters, force of mucoadhesion, release rate, and flux. Research conducted in this dissertation focused on two important aspects of transbuccal delivery, drug transport and mucoadhesion by studying a model drug and polymer blends. The results obtained in these investigations can be utilized in the development of other bioadhesive delivery systems with respect to drug transport and mucoadhesion. Polymer blends of polyvinyl alcohol (PVA) and sodium alginate (Alg) were prepared to evaluate their mucoadhesive properties and investigate mucoadhesive mechanism by a Lewis acid-base approach. (Abstract shortened by UMI.)
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Warrilow, Philip A. D. "Polyamine conjugates as a potential drug delivery system." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30012.

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The work in this thesis has covered three main topics; i) cytotoxic polyamine-conjugates ii) radiation protection polyamine-conjugates iii) polyamine conjugates which probe cellular uptake and DNA binding. The synthesis of these conjugates employed selective protection/deprotection steps, taking advantage of the BOC protecting groups regioselectivity of primary over secondary amines when reacting with naturally occurring polyamines. After promising in vitro and in vivo results of the original spermidine-chlorambucil synthesised by Wheelhouse (1990), attempts were made to improve this compound. The terminal amines were ethylated. The new diethyl derivative showed greater inhibition of [C14] labelled spermidine entry into cultured cells, and improved cytotoxicity. Also a new novel cis-platin polyamine conjugate was synthesised and tested for cellular inhibition of radiolabelled spermidine and cytotoxicity. It failed to recognise the polyamine uptake receptor and gave poor [C14] spermidine inhibition results and subsequently cytotoxicity. Two radiation protection polyamine agents were synthesised and tested against the indirect radiation damage pathway, both N1 and N4 mercaptoethyl spermidine. They both showed very good inhibition of [C14] labelled spermidine entry, the N1 derivative being twice as efficient as the N4. Dilute aqueous solutions of DNA were irradiated with various thiols present. Surprisingly the positively charged thiols protected to a similar extent as the negatively charged thiols, as it was expected that the primary mechanism for protection against the indirect effect was bulk water scavenging of the hydroxyl radical. An EDTA-polyamine conjugate was also synthesised and investigated and it showed moderate [C14] labelled spermidine inhibition and cytotoxicity in preliminary experiments. The cytotoxicity was due to the fact that EDTA chelation to iron (II) produces hydroxyl radicals.
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Bosworth, Mark Erwin. "Evaluation of liposomes as a drug delivery system /." Ann Arbor : University Microfilms International, 1987. http://www.gbv.de/dms/bs/toc/016141032.pdf.

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Książki na temat "Pulsatile drug delivery system"

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Jain, Kewal K., ed. Drug Delivery System. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0363-4.

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Shah, Nirmal, ed. Nanocarriers: Drug Delivery System. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6.

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Frost & Sullivan., ed. Programmed drug delivery system markets. Frost & Sullivan, 1988.

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P, Johnson, and Lloyd-Jones J. G. 1944-, eds. Drug delivery system: Fundamentals and techniques. VCH, 1988.

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Jain, Kewal K., ed. Drug Delivery to the Central Nervous System. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-529-3.

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F, Smolen Victor, and Ball LuAnn, eds. Bioavailability control by drug delivery system design. Wiley, 1985.

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Parfenyuk, E. V. Silica nanoparticles as drug delivery system for immunomodulator GMDP. ASME, 2012.

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David, Ganderton, Jones T. M. 1942-, Pharmaceutical Society of Great Britain., and King's College (University of London). Chelsea Dept. of Pharmacy., eds. Drug delivery to the respiratory tract. VCH, 1987.

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Gregory, Gregoriadis, McCormack Brenda, Poste George, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Targeting of Drugs: Advances in System Constructs (1993 : Ákra Soúnion, Greece), eds. Targeting of drugs 4: Advances in system constructs. Plenum Press, 1994.

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Geest, Ronald van der. PK/PD based drug delivery system design: Iontophoretic apomorphine delivery in patients with Parkinson's disease. University of Leiden], 1998.

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Części książek na temat "Pulsatile drug delivery system"

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Kawabuchi, Minako, Atsushi Watanabe, Masayasu Sugihara, Akihiko Kikuchi, Yasuhisa Sakurai, and Teruo Okano. "The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_106.

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Thitinan, Sumalee, and Jason T. McConville. "Pulsatile Delivery for Controlling Drug Release." In Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_9.

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Makino, Kimiko. "Drug Delivery System." In Electrical Phenomena at Interfaces and Biointerfaces. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118135440.ch40.

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Godin, Biana, Elka Touitou, Rajaram Krishnan, et al. "Drug Delivery System." In Encyclopedia of Nanotechnology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100192.

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Yang, Qiuhong, and Laird Forrest. "Drug Delivery to the Lymphatic System." In Drug Delivery. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118833322.ch21.

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On, Ngoc H., Vinith Yathindranath, Zhizhi Sun, and Donald W. Miller. "Pathways for Drug Delivery to the Central Nervous System." In Drug Delivery. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118833322.ch16.

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Zhang, Yan, and Donald W. Miller. "Pathways for Drug Delivery to the Central Nervous System." In Drug Delivery. John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471475734.ch3.

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Choudhary, Princy, and Sangeeta Singh. "Targeted Drug Delivery." In Biotechnology in the Modern Medicinal System. Apple Academic Press, 2021. http://dx.doi.org/10.1201/9781003129783-2.

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Gujarathi, Nayan A., Akshada A. Bakliwal, Bhushan R. Rane, et al. "Pulmonary Drug Delivery System." In Topical and Transdermal Drug Delivery Systems. Apple Academic Press, 2022. http://dx.doi.org/10.1201/9781003284017-9.

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Pillai, Akhilraj, Dhanashree Bhande, and Vinal Pardhi. "Controlled Drug Delivery System." In Studies in Mechanobiology, Tissue Engineering and Biomaterials. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6564-9_11.

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Streszczenia konferencji na temat "Pulsatile drug delivery system"

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M, Moorthi, Gugan B.M, Mohammed Suhail K.S, et al. "Microfluidic Analysis of Micro Needle for Drug Delivery." In 2024 Control Instrumentation System Conference (CISCON). IEEE, 2024. http://dx.doi.org/10.1109/ciscon62171.2024.10696860.

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Jaiswal, Shalini, Pooja Singh, Shalini Srivastav, Renu Chaudhary, and Atul Kumar. "Noval Technology of Nano-Robot for Promising Drug Delivery System." In 2024 7th International Conference on Contemporary Computing and Informatics (IC3I). IEEE, 2024. https://doi.org/10.1109/ic3i61595.2024.10829002.

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Maloney, John M. "An Implantable Microfabricated Drug Delivery System." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43186.

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We report on the development of a fully implantable drug delivery system capable of delivering hundreds of individual doses. This product is intended for the controlled release of potent therapeutic compounds that might otherwise require frequent injections. Our system has the following capabilities: • Stable, hermetic storage of therapeutic drugs in solid, liquid, or gel form; • Individual storage of discrete doses for multiple-drug regimens; • Wireless communication with an external controller for device monitoring and therapy modification; • Choice of preprogrammed release or release on command; • Controlled pulsatile or continuous release. MicroCHIPS’ drug release technology has been successfully demonstrated in vitro and in vivo. We are proceeding with long-term in vivo studies of a fully implantable device containing one hundred individual doses. A future device intended for human clinical trials will contain four hundred doses, enough for a daily release of drug for more than one year.
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Divetia, Asheesh, Nolan Yoshimura, Guann-Pynn Li, Baruch D. Kuppermann, and Mark Bachman. "Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38054.

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Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer upon contact with water and the resulting pressure generated is used as an actuation mechanism to release drugs from each reservoir. The programmable release of the drug from the device is achieved by controlling the diffusion rate of water from the surrounding environment into each reservoir. The drug is released from the reservoir when the swellable polymer absorbs water from the environment and generates enough pressure to break an overlying rupturable membrane. We have demonstrated that controlled and pulsatile drug delivery can be achieved using this delivery device, without any external power or control.
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Keyes, Joseph T., Bruce R. Simon, and Jonathan P. Vande Geest. "Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53998.

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Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].
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Kadam, Sagar, Shashikant Dhole, and Soham Chitlange. "“FORMULATION AND EVALUATION OF CHRONOTHERAPEUTIC PULSATLE DRUG DELIVERY SYSTEM”." In 42nd International Academic Conference, Rome. International Institute of Social and Economic Sciences, 2018. http://dx.doi.org/10.20472/iac.2018.042.027.

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Divetia, Asheesh, Baruch D. Kuppermann, Guann-Pyng Li, and Mark Bachman. "Diffusion Controlled, Water-Powered Microactuator for Biomedical and Microfluidic Applications." In ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2007. http://dx.doi.org/10.1115/icnmm2007-30225.

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Current and advanced microfluidic and implantable biomedical devices present an increasing need for controlled mechanical actuation at the micro-scale, without the use of batteries or external power. Implantable applications such as drug delivery microdevices require long term, battery free operation to perform their operation over the course of many months or years. In this paper, we present a micro-electro-mechanical systems (MEMS) microactuator which is water-powered and does not require any external power or control for its operation. Furthermore, we have demonstrated that by controlling the diffusion of water through a lithographically defined semi-permeable membrane, we can control the rate of this mechanical actuation. The microactuator uses a water-swellable polymer as the working agent and a thin membrane of PDMS (polydimethylsiloxane) as the semi-permeable membrane to allow selective diffusion of water into the actuator. The swelling of the polymer upon contact with water and the resulting pressure generated is used as the actuation mechanism. Self-powered microactuators that use this technology can be important for many microfluidic and biomedical applications such as pulsatile drug delivery.
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Huang, Song-Bin, Min-Hsien Wu, Zhanfeng Cui, Zheng Cui, and Gwo-Bin Lee. "Microdfluidic Based 3-Dimensional Cell Culture Platform." In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52292.

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This study reports a new perfusion-based, micro three-dimensional (3-D) cell culture platform for drug testing using enabling microfluidic technologies. In this work, a perfusion-based, micro 3-D cell culture platform is designed and is fabricated based on SU-8 lithography and polydimethylsiloxane (PDMS) replication processes. One of the key features of the system is that the incorporation of a multiple medium pumping mechanism, consisting of 15 membrane-based pneumatic micropumps with serpentine-shape (S-shape) layout, coupled with a pneumatic tank, into the micro 3-D cell culture platform to provide efficient and economical culture medium delivery. Moreover, a “smart cell/agarose (scaffold) loading mechanism” was proposed, allowing the cell/3-D scaffold loading process in one step and avoiding too much laborious works and manual error. The results show that in all of the 15 S-shape pneumatic micropumps studied, the medium delivery mechanism is able to provide a uniform flow output ranging from 5.5 to 131 μl/hr depending on the applied pulsation frequency of the micropumps. In addition, the cell/agarose (scaffold) loading mechanism was proved to be able to perform sample loading tasks precisely and accurately in all of the 15 microbioreactors integrated. Furthermore, anti-cancer drug testing was successfully demonstrated using the proposed culture platform and fluorescent microscopic observation. As a whole, because of miniaturization, not only does this perfusion 3-D cell culture platform provide a homogenous and steady cell culture environment, but it also reduces the need for human intervention. Moreover, due to the integrated pumping of the medium and the cell/agarose (scaffold) loading mechanisms, time efficient and economical research work can be achieved. These characteristics are found particularly useful for high-precision and high-throughput 3-D cell culture-based drug testing.
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Bin Wang, Junhui Ni, Y. Litvin, D. W. Pfaff, and Qiao Lin. "A microfluidic device for pulsatile transdermal delivery for neurobiological drugs." In 2010 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS 2010). IEEE, 2010. http://dx.doi.org/10.1109/nems.2010.5592603.

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"Drug Delivery System." In 2004 2nd IEEE/EMBS International Summer School on Medical Devices and Biosensors. IEEE, 2004. http://dx.doi.org/10.1109/issmd.2004.1689583.

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Raporty organizacyjne na temat "Pulsatile drug delivery system"

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McPhillips, D. M., M. W. Price, J. W. Gibson, and R. A. Casper. Development of an On-Demand, Generic, Drug-Delivery System. Defense Technical Information Center, 1985. http://dx.doi.org/10.21236/ada158550.

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Pflugfelder Ghanashyam S., Stephen C. Broadly Applicable Nanowafer Drug Delivery System for Treating Eye Injuries. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613401.

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Dash, Alekha K. Novel in Situ Gel Drug Delivery System for Breast Cancer Treatment. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada474685.

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Silva, João, Matheus Warmeling, and Rogério Pagnoncelli. Platelet-rich fibrin as a drug delivery system: a scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.8.0004.

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Sledge, George W. Nanoparticle: Monoclonal Antibody Conjugates: A Novel Drug Delivery System in Human Breast Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada420569.

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Sledge, George. Nanoparticle: Monoclonal Antibody Conjugates: A Novel Drug Delivery System in Human Breast Cancer. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada393348.

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Choi, Soojeong, Seoeun Oh, and Ildoo Chung. Synthesis and characterization of L-lysine polyurethane (LPU) nanoparticles for drug delivery system. Peeref, 2023. http://dx.doi.org/10.54985/peeref.2307p9824908.

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Choi, Soojeong, Seoeun Oh, and Ildoo Chung. Synthesis and characterization of L-threonine polyurethane (LTHU) nanoparticles for drug delivery system. Peeref, 2023. http://dx.doi.org/10.54985/peeref.2307p3992803.

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Chakraborty, Payel, and Tamilvanan Shunmugaperumal. Simvastatin repurposing towards endometriosis management: The use of self -nanoemulsifying drug delivery system. Peeref, 2023. http://dx.doi.org/10.54985/peeref.2304p6131285.

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Silva, João, Matheus Warmeling, and Rogerio Pagnoncelli. Platelet-rich fibrin as a drug delivery system: Systematic review of in vitro studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.8.0005.

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