Gotowe bibliografie tematyczne / Red cell ligands

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Gotowa bibliografia na temat „Red cell ligands”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Red cell ligands"

Smith, Christof, Sarah Entwistle, Caryn Willis, et al. "478 Translation of a therapeutic neoantigen vaccine workflow to SARS-CoV-2 vaccine development." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A510—A512. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0478.

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BackgroundThere is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE) (figure 1). Leveraging methods initially developed for prediction of tumor-specific antigen targets, we combine computational prediction of T cell epitopes, recently published B cell epitope mapping studies, and epitope access

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Li, Tong, Nan Li, Yao Ma, Yun-Jie Bai, Cheng-Mei Xing, and Yong-Kuan Gong. "A blood cell repelling and tumor cell capturing surface for high-purity enrichment of circulating tumor cells." Journal of Materials Chemistry B 7, no. 40 (2019): 6087–98. http://dx.doi.org/10.1039/c9tb01649j.

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Irmler, Manfred, and Gerd Meyer. "Notizen: Molekülstruktur von Re3Cl6(Acac)3 im Feststoff / Molecular Structure of Re3Cl6(Acac)3 in the Solid State." Zeitschrift für Naturforschung B 45, no. 7 (1990): 1103–4. http://dx.doi.org/10.1515/znb-1990-0735.

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Dark red single crystals of Re3Cl6(Acac)3 are obtained from a solution of “ReCl3·2H2O” in acetylacetone by slow evaporation. The unit cell (monoclinic, P21/c, a = 1687.3(9), b = 963.4(5), c = 1664.3(9) pm, β = 108.97(4)°) contains four molecules of Re3Cl6(Acac)3. Each of the bidentate Acac(—) ligands substitutes one of the in-plane terminal and one of the out-of-plane terminal ligands with respect to the Re3 triangle.

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Marginedas-Freixa, Irene, Cora Alvarez, Martina Moras, et al. "Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands." International Journal of Molecular Sciences 19, no. 10 (2018): 3098. http://dx.doi.org/10.3390/ijms19103098.

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Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic reticulum. The design of specific tools is necessary to determine the molecular associations and functions of TSPO, which remain controversial nowadays. We recently demonstrated that TSPO2 is involved in a supramolecular complex of the erythrocyte membrane, where micromolar doses of the classical TSPO

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Paulitschke, M., GB Nash, DJ Anstee, MJ Tanner, and WB Gratzer. "Perturbation of red blood cell membrane rigidity by extracellular ligands." Blood 86, no. 1 (1995): 342–48. http://dx.doi.org/10.1182/blood.v86.1.342.bloodjournal861342.

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It is known that binding of extracellular antibodies against the major sialoglycoprotein, glycophorin A, reduced the deformability of the red blood cell membrane. This has been taken to result from new or altered interactions between the glycophorin A and the membrane skeleton. We have shown by means of the micropipette aspiration technique that antibodies against the preponderant transmembrane protein, band 3, induce similar effects. A definite but much smaller reduction in elasticity of the membrane is engendered by univalent Fab fragments of the anti-band 3 antibodies. By examining cells ge

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Smet, P. W., T. F. Pauwels, and P. J. Dierickx. "The effect of hexaaza-and hexathia–macrocyclic ligands on transition metal cytotoxicity in human hepatoma-derived cultured cells." Human & Experimental Toxicology 21, no. 8 (2002): 421–27. http://dx.doi.org/10.1191/0960327102ht277oa.

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The effect of macrocyclic ligands on cytotoxic concentrations of the transition metal ions of copper, zinc, and cadmium was investigated. For this purpose, a hexaaza-[3,6,9,17,20,23-hexaazatricyclo[23.3.1.111,15] triaconta–1(29),11(30),12,14,25,27–hexaene (L2)] and hexathia-chelating ligand [1,4,7,10,13,16-hexathiacyclooctadecane (L3)] were used in the human hepatoma-derived HepG2 cell line. The cytotoxicity was measured by the neutral red uptake inhibition assay. First, the NI50 of the ligands, i.e., the concentration of the ligand inducing a 50% inhibition in neutral red uptake compared to c

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Cao, Fei, Antonio Castrillo, Peter Tontonoz, Fabio Re, and Gerald I. Byrne. "Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2." Infection and Immunity 75, no. 2 (2006): 753–59. http://dx.doi.org/10.1128/iai.01386-06.

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ABSTRACT Chlamydia pneumoniae induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (LDL). This study examined the role that Toll-like receptor 2 (TLR2) and TLR4 may play in pathogen-induced foam cell formation. Murine macrophage RAW 264.7 cells either infected with C. pneumoniae or treated with the TLR4 ligand E. coli lipopolysaccharide (LPS) or the TLR2 ligand Pam3-Cys-Ala-Gly-OH (Pam) became Oil Red O-stained foam cells and showed increased cholesteryl ester (CE) content when cocultured with LDL. In macrophages from TLR2−/− m

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Farrés, Judith, Susanna Burckhardt-Herold, Jan Scherrer, Alexander D. Frey, and Pauli T. Kallio. "Analysis of the contribution of the globin and reductase domains to the ligand-binding properties of bacterial haemoglobins." Biochemical Journal 407, no. 1 (2007): 15–22. http://dx.doi.org/10.1042/bj20070668.

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Bacterial Hbs (haemoglobins), like VHb (Vitreoscilla sp. Hb), and flavoHbs (flavohaemoglobins), such as FHP (Ralstonia eutropha flavoHb), have different autoxidation and ligand-binding rates. To determine the influence of each domain of flavoHbs on ligand binding, we have studied the kinetic ligand-binding properties of oxygen, carbon monoxide and nitric oxide to the chimaeric proteins, FHPg (truncated form of FHP comprising the globin domain alone) and VHb-Red (fusion protein between VHb and the C-terminal reductase domain of FHP) and compared them with those of their natural counterparts, FH

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Rosin-Arbesfeld, Rina, Michal Caspi, Ronen Siman-Tov, Yakir Levi, and Chava Perry. "Wnt Signaling in Red Blood Cells." Blood 128, no. 22 (2016): 4806. http://dx.doi.org/10.1182/blood.v128.22.4806.4806.

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Abstract Introduction : Red blood cells (RBCs) are the most common cell type in the human body. These cells deliver oxygen to the body's tissues and are composed of a cytoplasm that is rich in hemoglobin and is surrounded by a membrane that is essential for the cells function by providing properties such as stability and deformability. The membrane is composed of a lipid bilayer, transmembrane proteins, and a filamentous meshwork of proteins such as actin and adducin that forms the cells cytoskeleton along the entire cytoplasmic surface of the membrane. RBCs lack a nucleus and other cellular o

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Mangalmurti, Nilam S., Jessica Friedman, Don L. Siegel, Janet Lee, and Steven M. Albelda. "Erythrocyte Advanced Glycation End-Products as Novel Mediators of Endothelial Dysfunction Following Transfusion." Blood 120, no. 21 (2012): SCI—47—SCI—47. http://dx.doi.org/10.1182/blood.v120.21.sci-47.sci-47.

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Abstract Abstract SCI-47 Red cell transfusions are associated with the development of acute lung injury in critically ill patients, yet the mechanisms for this association remain unknown. We have previously shown that stored red blood cells (RBCs) express the advanced glycation end-product Nε-carboxymethyl lysine (Nε-CML) (1). Advanced glycation end-products (AGEs), a heterogeneous group of adducts formed during states of increased oxidative stress or hyperglycemia, are thought to exert their effects by binding to membrane receptors, including RAGE (the receptor for advanced glycation-end prod

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Rozprawy doktorskie na temat "Red cell ligands"

DE, ROSA GIANLUCA. "UNRAVELING THE MOLECULAR PATHOGENESIS OF INEFFECTIVE ERYTHROPOIESIS IN CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II: IN VITRO EVALUATION OF RAP-011 TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/697529.

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Congenital Dyserythropoietic Anemias (CDAs) are subtypes of bone marrow failure syndromes, hallmarked by ineffective erythropoiesis. The most common form is CDA type II (CDAII), showing moderate/severe anemia, relative reticulocytopenia, jaundice, splenomegaly, and iron overload. It is inherited as an autosomal recessive disorder due to loss-of-function mutations in the SEC23B gene. Molecular pathogenesis of CDA II still has to be investigated because the described animal models did not recapitulate the clinical features observed in humans. To date, treatments for CDAII patients consist of sup

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Li, Simin. "Quantitative studies of RET activation, deactivation and trafficking kinetics upon stimulation by its natural ligand Artemin." Thesis, 2016. https://hdl.handle.net/2144/17712.

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Receptor tyrosine kinases (RTKs) are key regulators of critical cellular processes, such as cell cycle, differentiation, proliferation, apoptosis and survival. Mutations, hyperactivity and loss of function of RTKs are responsible for numerous diseases. Because of the therapeutic importance of RTK signaling, intensive studies have been devoted to understanding the signaling mechanisms of RTKs, and the key components in their signaling networks. However, studying the cellular responses to RTK stimulation in a native cellular context is technically challenging. Consequently, many details of RTK s

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Baradji, Issa. "The Role of Apical Membrane Antigen-1 in Erythrocyte Invasion by the Zoonotic Apicomplexan Babesia microti." 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-68.

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Babesia microti is a tickborne hemoprotozoan parasite that causes the disease babesiosis in humans. Babesia microti Apical Membrane Antigen-1 (AMA-1) is a micronemal protein suspected to play a role in erythrocyte invasion. To investigate interaction between AMA-1 and the host cell, the ectodomain region of the B. microti ama-1 gene was cloned into an expression vector, expressed as a histidine-tagged fusion protein, and used to probe red blood cell membrane proteins in far Western blot assays. The B. microti ama-1 ectodomain, which excludes the signal peptide and the transmembrane region of t

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Fessing, Michael Y., R. Atoyan, B. Shander, et al. "BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts." 2010. http://hdl.handle.net/10454/5967.

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BMP signaling has a crucial role in skin development and homeostasis, whereas molecular mechanisms underlying its involvement in regulating gene expression programs in keratinocytes and fibroblasts remain largely unknown. We show here that several BMP ligands, all BMP receptors, and BMP-associated Smad1/5/8 are expressed in human primary epidermal keratinocytes and dermal fibroblasts. Treatment of both cell types by BMP-4 resulted in the activation of the BMP-Smad, but not BMP-MAPK pathways. Global microarray analysis revealed that BMP-4 treatment induces distinct and cell type-specific change

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Shakibaei, M., C. Buhrmann, and A. Mobasheri. "Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells." 2011. http://hdl.handle.net/10454/6182.

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Resveratrol is a polyphenolic phytoestrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory, and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activities result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis and osteoporosis. Receptor activator of NF-kappaB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study, we investigated the effects of resveratrol on RANKL during bone morphogenesis in high density bone cultures in

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Liu, B., Y. F. Liu, Y. R. Du, et al. "Cbx4 regulates the proliferation of thymic epithelial cells and thymus function." 2013. http://hdl.handle.net/10454/6068.

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Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific deletion of Cbx4 shows that the compromised thymopoiesis is rooted in a defective epithelial compartment. Cbx4-deficient TECs exhibit impaired proliferative cap

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Części książek na temat "Red cell ligands"

Olson, John S. "From O2 Diffusion into Red Blood Cells to Ligand Pathways in Globins." In Dioxygen Binding and Sensing Proteins. Springer Milan, 2008. http://dx.doi.org/10.1007/978-88-470-0807-6_14.

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"The Sporozoite, the Merozoite and the Infected Red Cell: Parasite Ligands and Host Receptors." In Malaria. CRC Press, 1999. http://dx.doi.org/10.1201/b17000-15.

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Acheson, Ann, and Warren J. Gallin. "Generation and characterization of function-blocking anti-cell adhesion molecule antibodies." In Cell-Cell Interactions. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199633197.003.0002.

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Abstract Cell adhesion molecules (CAMs) are cell-surface molecules that mediate the adhesion of one cell type to another. There are two classes of CAMs defined by the ability of calcium ions to regulate their binding, calcium-dependent and calcium-independent. The neural cell adhesion molecule (NCAM) and Ll are examples of calcium-independent CAMs, and the cadherin family mediate calcium-dependent binding (see ref. 1 for review). Many CAMs are homophilic ligands, i.e. they bind to themselves, functioning as their own receptor (1).

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Rowland-jones, Sarah L. "Human cytotoxic T-lymphocyte (CTL) studies." In Lymphocytes. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199638178.003.0007.

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Abstract Cytotoxic T-lymphocytes (CTLs) play a major part in the cellular immune response to viruses and other intracellular infections, and in the control of many tumours. They are able to recognize cells expressing foreign antigens through a specific interaction of their T-cell receptors (TCRs) with surface class-I HLA molecules on the target cells which have bound peptides from the pathogen or tumour antigens. This leads to the release of cytokines such as interferon-gamma (IFN--y) and tumour necrosis factor-alpha (TNF-a), chemokines such as RANTES and MIP-la, and ultimately to the lysis of

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"Cytotoxic activity of macrocyclic Lu (III) complexes." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.21.2.

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Aim: Two newly synthesized complexes [[Lu2tpmcCl2(H2O)2](BF4)4∙2NaBF4 and [Lucyc(H2O)2] (BF4)3∙NaBF4 were tested against human lung carcinoma cell line A549 and the non-malignant, human lung fibroblast cell line MRC-5. The values of IC50 were calculated. Material and Methods. Cell Culture. The human lung carcinoma cell line A549 (CCL-185) and the non-malignant human lung fibroblast cell line MRC-5 (CCL-171) were procured from the American Type Culture Collection. The cells were grown in Dulbecco's Modified Eagle Medium (DMEM), supplemented with 10% fetal bovine serum, and a solution of penicil

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Labrude, P., B. Chaillot, E. Dellacherie, J. F. Stoltz, and C. Vigneron. "Hemoglobin Solutions as Oxygen Carriers: Ligands and Other Molecules Interactions with Hemoglobin." In Oxygen Transport in Red Blood Cells. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-030800-5.50021-4.

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Storz, Jay F. "Hemoglobin structure and allosteric mechanism." In Hemoglobin. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198810681.003.0004.

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Chapter 4 provides an overview of hemoglobin structure and explains the mechanistic basis of ligand-binding dynamics and allosteric effects. The chapter provides an overview of decades of research on structure-function relationships based on X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. This body of work has provided atomic level insights into the structural mechanisms underlying key functional properties. The chapter also reviews experimental data on the ligand-binding behavior of hemoglobin, and discusses how the oxygenation properties of blood reflect a complex an

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Winterhalter, K. H., and E. E. Di Iorio. "Influence of Heme Pocket Geometry on Ligand Binding to Heme Proteins." In Oxygen Transport in Red Blood Cells. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-030800-5.50007-x.

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Cladera, Josep, and Paul O’Shea. "Generic techniques for fluorescence measurements of protein-ligand interactions; real-time kinetics and spatial imaging." In Protein-Ligand Interactions: structure and spectroscopy. Oxford University PressOxford, 2001. http://dx.doi.org/10.1093/oso/9780199637508.003.0004.

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Abstract The non-covalent interactions of small molecules (i.e. the ‘ligand’) with a larger molecule (the ‘receptor’—usually a protein or nucleic acid) underlies much of the ‘process’ of cell biology and physiology as illustrated by the broad range of examples covered in this volume. Whilst there are techniques available that offer very accurate quantitative and unequivocal measurements of ligand-receptor interactions (see, e.g. ref. 1, and other chapters in the present volumes), many such techniques are highly specialized and/or dedicated to a particular biological phenomenon. A number of mor

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Homeister, Jonathon W., and John B. Lowe. "Carbohydrate recognition in leukocyte-endothelial cell interactions." In Molecular and Cellular Glycobiology. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199638079.003.0002.

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Abstract Mammalian cell surfaces are decorated with complex carbohydrate molecules, also known as oligosaccharides or glycoconjugates. These molecules display a remarkable degree of structural diversity, which is in turn a function of the cell type or tissue, or the particular stage of development of the cell or tissue. Cell surface oligosaccharide structure varies with the differentiation state or lineage of a cell. These observations suggest that these molecules play important roles in mediating information transfer into and out of the cell. During mammalian development, for example, dynamic

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Streszczenia konferencji na temat "Red cell ligands"

Long, Mian, Harry L. Goldsmith, and Cheng Zhu. "Probabilistic Modeling of Formation and Breakage of Cell Aggregates in a Shear Field." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0236.

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Abstract Previously, we employed the probabilistic formulation of McQuarrie [1] to model the no-load adhesion kinetics of cell-cell adhesion [2] and the steady state detachment of cells from surfaces [3]. Here we extend our model to describe the shear-induced formation and breakage of doublets of red cells [4] and latex spheres cross-linked by ligands [5]. We solved the probabilities of having adhesive bonds linking two spheres from the master equations [1], enabling us to calculate various statistical aspects of the experimental data, including the mean and variance of formation and breakage

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Sembiring, Zipora, Syaiful Bahri, Agung Abadi Kiswandono, Afra Nabila Saputri, and Ninid Widya Sari Lubis. "Synthesis and application of manganese (II) complex with congo red and rhodamine B ligands as sensitizer in dye-sensitized solar cell (DSSC)." In THE 4TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCES, MATHEMATICS, AND INFORMATICS: ICASMI2022. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0216113.

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Zhu, Cheng, and Scott E. Chesla. "Dissociation of Individual Molecular Bonds Under Force." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0286.

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Abstract Specific interactions between receptors on cell surfaces are essential for living organisms to sense and adapt to their environment. For example, CD16A (Feγ receptor IIIA) signals a variety of immune functions upon binding of immunoglobulin (Ig) G. While receptor-ligand binding has been extensively studied in chemical terms, only until very recently has direct measurement of individual bond forces become possible. Evans et al. [1] pioneered the use of the micropipet technique to measure detachment forces between two red blood cells (RBC) crosslinked by antibodies. While these authors

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Imai, Yohsuke, Hitoshi Kondo, Young Ho Kang, Takuji Ishikawa, Chwee Teck Lim, and Takami Yamaguchi. "A Numerical Model of Adhesion Property of Malaria Infected Red Blood Cells in Micro Scale Blood Flows." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206456.

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Infection by malaria parasite changes mechanical properties of red blood cells (RBCs). Infected red blood cells (IRBCs) lose the deformability but also develop the ability to cytoadhere and rosetting. These outcomes can lead to microvascular blockage [1]. The stiffness of IRBCs [2] and its effects on the flow in micro channels [3] were studied with recent experimental techniques. The cytoadherence and rosetting properties of IRBCs have also been studied experimentally. The cytoadherence is mediated by the interaction of the parasite protein PfEMP1 with several endothelial adhesion molecules, s

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Cho, Hongkwan, Abdul Sheikh, and Daria A. Narmoneva. "Non-Specific Endothelial Cell Interactions With the Substrate Result in Cell Activation and Angiogenesis In Vitro." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19094.

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Vascularization is critical for success of tissue engineering applications. Previous studies by us and others have shown that self-assembling peptide nanoscaffold RAD16-II promotes de novo capillary formation (angiogenesis) in vitro and neovascularization in vivo, and is a promising material for tissue engineering applications [1, 2]. However, the molecular mechanisms for cell interactions with this material are not known. Angiogenesis is mediated via interactions between integrins, which are expressed on the surface of activated endothelial cells (ECs), and extracellular matrix proteins. Amon

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Goldsmith, Harry L. "Observing Human Blood Cells in Flow Through Microchannels." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-31330.

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For the rheologist, blood is essentially a concentrated suspension of biconcave 8-μm diameter red cells (40–45% by volume) that circulates within the body in vessels from 25 mm down to 5 μm diameter. Here, we describe in vitro tracking of blood cells in a traveling microtube apparatus and in a counter-rotating micro cone-plate device at low Reynolds numbers, Re. Observations of the flow behavior of individual red cells reveal a marked and continuously changing deformation and interaction of the cells in shear, and this, together with their migration away from the vessel wall accounts for the l

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Bussel, J. "FOR MODULATION AS A MEANS OF ELEVATING THE PLATELET COUNT IN ITP." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644761.

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ITP is an autoantibody-mediated disease which would logically be treated by decreasing the level of autoantibody. However, the most exciting developments in understanding the pathophysiology of the thrombocytopenia and its treatment involve a better understanding of the MPS FcR system and ways in which it can be modulated. This work has focussed on phagocytic paralysis or FcR blockade (FcRBl): the slowing of destruction of antibody-coated platelets despite the persistent presence of antibody on the surface of the platelet.Several areas have been explored in learning about the MPS system. Inves

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