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Artykuły w czasopismach na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Zheng, Sheng, Guan-Yu Hu, Jun-Hua Li, and Yi-Kai Li. "Potential plausible role of Wharton’s jelly mesenchymal stem cells for diabetic bone regeneration." World Journal of Stem Cells 16, no. 8 (2024): 824–26. http://dx.doi.org/10.4252/wjsc.v16.i8.824.

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This letter addresses the review titled “Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury”. The review highlights the regenerative potential of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and describes why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine. The potential plausible role of WJ-MSCs for diabetic bone regeneration should be noticeable, which will provide a new strategy for improving bone regeneration under diabetic conditions.
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Greben, A. I., P. S. Eremin, E. Yu Kostromina, P. A. Markov, and I. R. Gilmutdinova. "Mesenchymal stem cells and exosomes in bone defects treatment." Genij Ortopedii 30, no. 1 (2024): 124–33. http://dx.doi.org/10.18019/1028-4427-2024-30-1-124-133.

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Introduction Bone defect management is a critical stage of treatment and rehabilitation that still remains a challenging problem for traumatologists and orthopaedists. The need for tissue engineering techniques is due to limited abilities of the human body to correct bone tissue autoregeneration, especially in comorbid and elderly patients with osteoporosis. Bone autografts is a gold standard in those cases but is associated with certain restrictions. Regenerative medicine and stem cell biology development opened up capabilities to employ new methods for enhancement of bone tissue repair. A sp
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Han, Yu, Xuezhou Li, Yanbo Zhang, Yuping Han, Fei Chang, and Jianxun Ding. "Mesenchymal Stem Cells for Regenerative Medicine." Cells 8, no. 8 (2019): 886. http://dx.doi.org/10.3390/cells8080886.

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In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We presen
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Sumer, Huseyin, Jun Liu, and Sangho Roh. "Mesenchymal Stem Cells and Regenerative Medicine." Stem Cells International 2018 (October 29, 2018): 1–3. http://dx.doi.org/10.1155/2018/9810972.

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Dokshin, P. M., and A. B. Malashicheva. "Heart stem cells: hope or myth?" Russian Journal of Cardiology 26, no. 10 (2021): 4749. http://dx.doi.org/10.15829/1560-4071-2021-4749.

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The search and study of endogenous heart repair remains an urgent issue in modern regenerative medicine. It is generally accepted that the human heart has a limited regenerative potential, but recent studies show that functionally significant regeneration is possible. However, the mechanisms underlying these processes remain poorly understood. In the heart, there are populations of resident mesenchymal cells that have some properties of stem cells that carry certain markers, such as c-kit+, Sca-1, etc. The ability of these cells to differentiate directly into cardiomyocytes remains controversi
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Caplan, Arnold I. "Adult Mesenchymal Stem Cells: When, Where, and How." Stem Cells International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/628767.

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Adult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. The medicinal effects are either immunomodulatory or trophic or both. When to deliver these mediators of regeneration, where, and by what delivery apparatus or mechanism will directly determine their medical efficacy. The MSCs help manage the innate regenerative capacity of almost every body tissue and the MSCs have only recently been fully appreciated. Perhaps the most skilled physician-manager of the body’s innate regener
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Rehman, Ayesha, Aditya Nigam, Luigi Laino, et al. "Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review." Medicina 59, no. 8 (2023): 1449. http://dx.doi.org/10.3390/medicina59081449.

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Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vesse
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Choudhery, Mahmood S., Taqdees Arif, Ruhma Mahmood, et al. "Induced Mesenchymal Stem Cells: An Emerging Source for Regenerative Medicine Applications." Journal of Clinical Medicine 14, no. 6 (2025): 2053. https://doi.org/10.3390/jcm14062053.

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Regenerative medicine is gaining interest in the medical field due to the limitations of conventional treatments, which often fail to address the underlying cause of disease. In recent years, stem cell-based therapies have evolved as a promising alternative approach to treat those diseases that cannot be cured using conventional medicine. Adult stem cells, particularly the mesenchymal stem cells (MSCs), have attracted a lot of attention due to their ability to regenerate and repair human tissues and organs. MSCs isolated from adult tissues are well characterized and are currently the most comm
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Skubis, Aleksandra, Bartosz Sikora, Nikola Zmarzły, Emilia Wojdas, and Urszula Mazurek. "Adipose-derived stem cells: a review of osteogenesis differentiation." Folia Biologica et Oecologica 12 (December 7, 2016): 38–47. http://dx.doi.org/10.1515/fobio-2016-0004.

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This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing or
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Fortier, Lisa Ann, Laurie Ruth Goodrich, Iris Ribitsch, et al. "One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses." Regenerative Medicine 15, no. 6 (2020): 1775–87. http://dx.doi.org/10.2217/rme-2019-0143.

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Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum. The purpose of this manuscript is to disseminate findings from a workshop on the development of translational regenerative medicine in the equine field. Five themes emerged: stem cell characterization and tenogenic differentiation; interactions between mesenchymal stem cells, other cells and the environment; scaffolds and cell packaging; blood- an
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Rozprawy doktorskie na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Perruisseau-Carrier, Claire. "Neuronal commitment of Umbilical Cord Mesenchymal Stem Cells for brain regenerative medicine." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10192.

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De nos jours, aucune prévention ou aucun remède efficace n'existe pour guérir les maladies du cerveau humain. Les cellules souches représentent un grand espoir pour la réparation et la régénération des tissus neuraux endommagés. L'objectif de cette thèse est d'évaluer la capacité des cellules souches du cordon ombilical humain (hUC MSCs) à se différencier en neurones, pour une thérapie cellulaire appliquée au cerveau. Nous avons isolé, multiplié et caractérisé les hUC MSCs naïves à l'échelle des gènes et des protéines. Ensuite, les e_ets sur l'expansion des hUC MSCs et leur différenciation neu
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Youngstrom, Daniel W. "Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64422.

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Tendon function is essential for quality of life, yet the pathogenesis and healing of tendinopathy remains poorly understood compared to other musculoskeletal disorders. The aim of regenerative medicine is to replace traditional tissue and organ transplantation by harnessing the developmental potential of stem cells to restore structure and function to damaged tissues. The recently discovered interdependency of cell phenotype and biophysical environment has created a paradigm shift in cell biology. This dissertation introduces a dynamic in vitro model for tendon function, dysfunction and devel
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Popielarczyk, Tracee. "Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78789.

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Mesenchymal stem cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and differentiation are the focus of this dissertation. Cell migration occurs in several physiological and pathological processes; migration mode and cell signaling
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Miller, Angela. "Peptide based hydrogels in the study of mesenchymal stem cells for the purposes of regenerative medicine." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6880/.

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Regenerative medicine is a vastly expanding subject area, with a number of different strategies and substrates being studied to ultimately create a model for repairing diseased and injured tissue. Stem cells are a promising cell type in this field as they are known to differentiate into a number of cell types and contribute to normal cell repair. However, despite their potential as a useful cell choice in the field of regenerative medicine, stem cell based therapies have limited potential due to their ability to form tumours when implanted in the human body, problems arising with immunogenicit
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Coffin, Spencer. "Extending the Window of Use for Human Mesenchymal Stem Cell Seeded Biological Sutures." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-theses/510.

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Cell therapy, including human mesenchymal stem cell (hMSC) therapy, has the potential to treat different pathologies, including myocardial infarctions (heart attacks). Biological sutures composed of fibrin have been shown to effectively deliver hMSCs to infarcted hearts. However, hMSCs rapidly degrade fibrin making cell seeding and delivery time sensitive. To delay the degradation process, we propose using aprotinin, a proteolytic enzyme inhibitor that has been shown to slow fibrinolysis. This project investigated the effects of aprotinin on hMSCs and suture integrity. Viability of hMSCs incub
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Sheard, Jonathan. "Screening and improving the safe provision of mesenchymal stem cells in regenerative medicine : an in vitro study." Thesis, Aston University, 2016. http://publications.aston.ac.uk/30085/.

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A number of studies have suggested that mesenchymal stem cells (MSCs) may undergo genetic alterations and spontaneous malignant transformation to form tumour cells, or at least can become contaminated with other cell types following extended periods in culture. Possible transformation or contamination of MSCs during cell culture expansion prior to their use in transplantation therapies is a risk, which should be taken into account. There is a continued need for the development of improved tools for monitoring safety and release criteria of cells intended for cell-based therapies. In order to h
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Lazin, Jamie Jonas. "The effect of age and sex on the number and osteogenic differentiation potential of adipose-derived mesenchymal stem cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34696.

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It has been shown that stem cells exist within adult adipose tissue. These stem cells are named adipose-derived mesenchymal stem cells (ASCs), are derived from the mesoderm, and can differentiate into a number of cells including osteoblasts, chondrocytes, and adipocytes. However, before these cells can be used clinically it is important that we understand how factors like age, sex, and ethnicity affect ASC number and potential. Additionally, since men and women vary in their distribution of adipose tissue, it will be important to see if the ideal source of ASCs is different for each sex. The
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Chan, Alexander K. C. "Development of characterisation and quality potency assays for human mesenchymal stem cells." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22977.

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Regenerative medicine and cell therapies hold great potential to treat a variety of medical conditions. Product characterisation of these therapies is particularly difficult as they pose regulatory challenges due to donor heterogeneity and the lack of standardised lot release tests that can reliably predict in vivo function. Human mesenchymal stem cells (hMSCs), also called multipotent stem cells or mesenchymal stromal cells, are a viable option in cell therapies due to their immunosuppressive and pro-angiogenic functions. Currently there are no standardised methods or potency assays to quanti
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Bogers, Sophie Helen. "Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/81746.

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Osteoarthritis (OA) is a degenerative disease of diarthrodial joints causing pain and loss of joint function. Etiology is heterogeneous, but commonly involves inflammation arising from impairment of normal tissue homeostasis and/or function. A cycle of low-grade inflammation and global tissue degradation causes alteration of tissue morphology and function via primary mechanisms or inability to withstand physiological forces. Current therapies variably ameliorate symptoms but do not modify progression. Mesenchymal stem cells (MSCs) have multi-modal properties but are ineffective in ameliorating
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VECCHIATINI, Renata. "Mesenchymal stem cells from Wharton's Jelly and periodontal ligament: reliable not controversial sources for osteogenic differentiation and regenerative medicine." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388818.

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Mesenchymal stem cells (MSCs) are uniquely capable of crossing germinative layers borders (these cell populations are able to differentiate towards ectoderm-, mesoderm- and endoderm- derived lineages) and are viewed as promising cells for regenerative medicine approaches in several diseases. Some undoubtedly limiting factors for the clinical use of MSCs, i.e. for the repair of bone defects, are related to many different problems, that only partially today can be overcome through ex-vivo expansion and cells modification strategies. Considering MSCs sources, the use of fetal annexes-deriv
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Książki na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Pham, Phuc Van. Liver, lung and heart regeneration. Springer, 2017.

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Taupin, Philippe. Stem cells and regenerative medicine. Nova Science Publishers, 2008.

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Audet, Julie, and William L. Stanford, eds. Stem Cells in Regenerative Medicine. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-060-7.

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Appasani, Krishnarao, and Raghu K. Appasani, eds. Stem Cells & Regenerative Medicine. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-860-7.

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Vertès, Alain A., Nasib Qureshi, Arnold I. Caplan, and Lee E. Babiss, eds. Stem Cells in Regenerative Medicine. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118846193.

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Taupin, Philippe. Stem cells and regenerative medicine. Nova Science Publishers, 2008.

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Julie, Audet, and Stanford William L. 1966-, eds. Stem cells in regenerative medicine. Humana, 2009.

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C, Low Walter, and Verfaillie Catherine M, eds. Stem cells and regenerative medicine. World Scientific, 2008.

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Fauza, Dario O., and Mahmud Bani, eds. Fetal Stem Cells in Regenerative Medicine. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3483-6.

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Illouz, Yves-Gerard, and Aris Sterodimas, eds. Adipose Stem Cells and Regenerative Medicine. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20012-0.

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Części książek na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Kuo, Tom K., Yueh-Hsin Ping, and Oscar K. Lee. "Mesenchymal Stem Cells for Liver Regeneration." In Stem Cells & Regenerative Medicine. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-860-7_10.

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El-Rashidy, Aiah A., Israa Ahmed Radwan, Dina Rady, et al. "Dental Mesenchymal Stem/Progenitor Cells: A New Prospect in Regenerative Medicine." In Stem Cells. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77052-5_9.

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Trivedi, Hargovind L., and Aruna V. Vanikar. "Mesenchymal Stem Cells and Transplantation Tolerance." In Regenerative Medicine: Laboratory to Clinic. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3701-6_24.

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Zhao, Weian, Debanjan Sarkar, James Ankrum, et al. "Therapeutic Applications of Mesenchymal Stem/Multipotent Stromal Cells." In Stem Cells & Regenerative Medicine. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-860-7_12.

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Wuchter, Patrick, Wolfgang Wagner, and Anthony D. Ho. "Mesenchymal Stem Cells: An Oversimplified Nomenclature for Extremely Heterogeneous Progenitors." In Regenerative Medicine. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9075-1_16.

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Wuchter, Patrick, Wolfgang Wagner, and Anthony D. Ho. "Mesenchymal Stem Cells – An Oversimplified Nomenclature for Extremely Heterogeneous Progenitors." In Regenerative Medicine. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5690-8_16.

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Miernik, Katarzyna, and Janusz Karasin´ski. "Existence of Mesenchymal-Like Somatic Stem Cells in the Porcine Uterus." In Regenerative Medicine. Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6542-2_19.

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Hosseini, Samaneh, Leila Taghiyar, Fatemeh Safari, and Mohamadreza Baghaban Eslaminejad. "Regenerative Medicine Applications of Mesenchymal Stem Cells." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/5584_2018_213.

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Minguell, Jose J. "Umbilical Cord-Derived Mesenchymal Stem Cells." In Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer London, 2010. http://dx.doi.org/10.1007/978-1-84882-718-9_25.

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Malemud, Charles J., and Eben Alsberg. "Mesenchymal Stem Cells and Immunomodulation: An Overview." In Stem Cell Biology and Regenerative Medicine. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46733-7_1.

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Streszczenia konferencji na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Al Fauzi, Asra. "Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells for Stroke: Rationale, Technique and Early Clinical Experience." In International Meeting on Regenerative Medicine. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007315700590064.

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Sudama, Hiroki, Atsushi Ogawa, Kei Saito, Wataru Ando, Norimasa Nakamura, and Hiromichi Fujie. "Effect of Shear Stress on Extracellular Matrix Production of Synovium-Derived Cells." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206331.

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It is well known that various fibrous tissue such as tendons and ligaments functionally adapt to dynamic and static loads. Although a variety of biomechanical studies have been done to deterimine the mechanism of remodeling in fibrous tissues, it was difficult to obtain detailed information because of complicated condstitution of the tissues. We have developed a stem cell-based self-assembled tissue (scSAT) [1] for tissue engineering. Since the scSAT is consisted of synovium-derived mesenchyaml stem cells and their native extracellular matrix, it is a good experimental model to determine the p
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de Souza, Ingrid Larissa Melo. "Responses of Skin Cells, Endothelial Cells and Macrophages Induced by Human Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Isolated from Microcarrier Culture." In International Conference on Cell Science and Regenerative Medicine. United Research Forum, 2024. https://doi.org/10.51219/urforum.2024.ingrid-larissa-melo-de-souza.

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Muhammad, Ikhwan, and Damayanti Tinduh. "Rehabilitation of Post Sciatic Nerve Repair with Mesenchymal Stem Cell Augmentation: A Case Report." In International Meeting on Regenerative Medicine. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007318401810185.

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Kumar, Arun, and Binil Starly. "Modeling Human Mesenchymal Stem Cell Expansion in Vertical Wheel Bioreactors Using Lactate Production Rate in Regenerative Medicine Biomanufacturing." In ASME 2016 11th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/msec2016-8787.

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Stem cells are critical components of regenerative medicine therapy. However, the therapy will require millions to billions of therapeutic stem cells. To address the need, we have recently cultured stem cells in 3D microgels and used them as a vehicle for cell expansion within a low shear stress rotating wheel type bioreactor within a 500ml volumetric setting. This study specifically highlights the cell encapsulation in microbead process, harvesting and operation of microbeads within a dynamic bioreactor environment. We have specifically encapsulated stem cells (human adipose derived) into mic
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Divieto, C., and M. P. Sassi. "Reproducible measurements of human mesenchymal stem cells counting and proliferation in 3D scaffolds for regenerative medicine." In 2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA). IEEE, 2015. http://dx.doi.org/10.1109/memea.2015.7145259.

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Shah, Vrushank, Usmaan Al-Shehab, Keyur Patel, and Alexander King. "Mesenchymal Stem Cell Therapy for Amyotrophic Lateral Sclerosis." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.148_2023.

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Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is a fatal neurodegenerative disease affecting motor neurons in the brain and spinal cord. Progressive muscle weakness, atrophy, and spasticity characterize the condition, which eventually leads to paralysis and respiratory failure. There is currently no cure for ALS, and the standard of care is supportive, with riluzole being the only approved medication that has been shown to slightly slow disease progression (1). However, the use of mesenchymal stem cells (MSCs) in the treatment of ALS is a new area of research in regene
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Suzuki, Osamu, and Takahisa Anada. "Synthetic octacalcium phosphate: A possible carrier for mesenchymal stem cells in bone regeneration." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609520.

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"Enhancement of mesenchymal stem cells liver regeneration potentialities in acute liver failure by authophagy suppression." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.168.

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Dougherty, John, Emily Schaefer, Ryan Niemeier, Erin Koch, Craig Cady, and Kalyani Nair. "Effect of Valproic Acid on Cell Proliferation of Wharton’s Jelly MSC in PCL Nanofiber Scaffolds." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65041.

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The field of tissue engineering and regenerative medicine is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. The process involves seeding cells onto biocompatible scaffolds that temporarily act as a supporting structure for cells to attach and grow. Scaffolds for tissue regeneration must present a viable microenvironment for the living cells to adhere, proliferate, and exhibit the necessary tissue function. Electrospinning is an emerging
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Raporty organizacyjne na temat "Regenerative Medicine Mesenchymal Stem-cells"

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Osathanon, Thanaphum, and Prasit Pavasant. Notch signaling in adipogenic differentiation of single-clone-derived mesenchymal stem cells isolated from human adipose tissue. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.5.

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Stem cells can be isolated from various tissues, including bone marrow, dental pulp, as well as adipose tissues. Due to the non-invasive isolation procedure, the adipose-derived mesenchymal stem cells (ADSCs) are introduced as an alternative stem cell source for regenerative medicine. In addition, it has been shown that Notch signaling participates in the control of ADSCs’ behavior. However, those studies were performed in the heterogeneous population of ADSCs. In the present study, human adipose tissue derived single-cell clones were isolated using a cloning ring technique and characterized f
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