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Artykuły w czasopismach na temat "Somatostatin positive interneuron"

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Halabisky, Brian, Fran Shen, John R. Huguenard, and David A. Prince. "Electrophysiological Classification of Somatostatin-Positive Interneurons in Mouse Sensorimotor Cortex." Journal of Neurophysiology 96, no. 2 (2006): 834–45. http://dx.doi.org/10.1152/jn.01079.2005.

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Classification of inhibitory interneurons is critical in determining their role in normal information processing and pathophysiological conditions such as epilepsy. Classification schemes have relied on morphological, physiological, biochemical, and molecular criteria; and clear correlations have been demonstrated between firing patterns and cellular markers such as neuropeptides and calcium-binding proteins. This molecular diversity has allowed generation of transgenic mouse strains in which GFP expression is linked to the expression of one of these markers and presumably a single subtype of
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Friend, Lindsey, Ryan Williamson, Collin Merrill, et al. "Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes." Molecules 24, no. 7 (2019): 1306. http://dx.doi.org/10.3390/molecules24071306.

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The hippocampus is thought to encode information by altering synaptic strength via synaptic plasticity. Some forms of synaptic plasticity are induced by lipid-based endocannabinoid signaling molecules that act on cannabinoid receptors (CB1). Endocannabinoids modulate synaptic plasticity of hippocampal pyramidal cells and stratum radiatum interneurons; however, the role of endocannabinoids in mediating synaptic plasticity of stratum oriens interneurons is unclear. These feedback inhibitory interneurons exhibit presynaptic long-term potentiation (LTP), but the exact mechanism is not entirely und
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Zhang, C., X. Liu, and T.-F. Yuan. "Somatostatin-positive GABAergic interneuron: new targets for depression." Molecular Psychiatry 22, no. 6 (2017): 790–91. http://dx.doi.org/10.1038/mp.2017.11.

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Yekhlef, Latefa, Gian Luca Breschi, Laura Lagostena, Giovanni Russo, and Stefano Taverna. "Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex." Journal of Neurophysiology 113, no. 5 (2015): 1616–30. http://dx.doi.org/10.1152/jn.00841.2014.

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GABAergic interneurons are thought to play a critical role in eliciting interictal spikes (IICs) and triggering ictal discharges in temporal lobe epilepsy, yet the contribution of different interneuronal subtypes to seizure initiation is still largely unknown. Here we took advantage of optogenetic techniques combined with patch-clamp and field recordings to selectively stimulate parvalbumin (PV)- or somatostatin (SOM)-positive interneurons expressing channelrhodopsin-2 (CHR-2) in layers II–III of adult mouse medial entorhinal cortical slices during extracellular perfusion with the proconvulsiv
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Jang, Hyun Jae, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, and Jeehyun Kwag. "Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex." Science Advances 6, no. 17 (2020): eaay5333. http://dx.doi.org/10.1126/sciadv.aay5333.

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Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of sp
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Shen, Wei, Ru Ba, Yan Su, et al. "Foxg1 Regulates the Postnatal Development of Cortical Interneurons." Cerebral Cortex 29, no. 4 (2018): 1547–60. http://dx.doi.org/10.1093/cercor/bhy051.

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AbstractAbnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1fl/fl with the Gad2-CreER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1-deficient interne
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Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunohistochemical visualization of mouse interneuron subtypes." F1000Research 3 (October 13, 2014): 242. http://dx.doi.org/10.12688/f1000research.5349.1.

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The activity of excitatory neurons is controlled by a small, but highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, so
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Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunofluorescent visualization of mouse interneuron subtypes." F1000Research 3 (November 20, 2014): 242. http://dx.doi.org/10.12688/f1000research.5349.2.

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The activity of excitatory neurons is controlled by a highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, somatostatin,
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Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunofluorescent visualization of mouse interneuron subtypes." F1000Research 3 (June 4, 2015): 242. http://dx.doi.org/10.12688/f1000research.5349.3.

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The activity of excitatory neurons is controlled by a highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, somatostatin,
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Fee, Corey, Mounira Banasr, and Etienne Sibille. "Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives." Biological Psychiatry 82, no. 8 (2017): 549–59. http://dx.doi.org/10.1016/j.biopsych.2017.05.024.

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Rozprawy doktorskie na temat "Somatostatin positive interneuron"

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Kaas, Thomas [Verfasser], Knut [Gutachter] Holthoff, Christian [Gutachter] Hübner, and Stefan Jens [Gutachter] Hallermann. "Beteiligung von Somatostatin-positiven Interneuronen an Giant Depolarizing Potentials in der CA1-Region des neonatalen Hippokampus von Mäusen in vitro / Thomas Kaas ; Gutachter: Knut Holthoff, Christian Hübner, Stefan Jens Hallermann." Jena : Friedrich-Schiller-Universität Jena, 2021. http://d-nb.info/1239177402/34.

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Yen, Ting-Yun, and 顏廷耘. "Synaptic Transmission between Long-Range Somatostatin-positive Dentate Interneurons and Remote Target cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/11123038043675674339.

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碩士<br>國立陽明大學<br>神經科學研究所<br>102<br>The hippocampus is a key brain structure best known for its role in learning and memory. The hippocampus is commonly divided into two main areas, the dentate gyrus (DG) and cornu ammonis (CA). Cortical information is transferred to the DG, the primary gate of the hippocampus, through perforant paths (PPs) and further relayed to other hippocampal areas. The DG is a well-laminated structure composed of the molecular layer (ML), the granule cell layer (GCL), and hilus (HI). The DG contains heterogenous types of neurons including glutamatergic excitatory principal
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Huang, Tzu-Hsuan, and 黃子瑄. "Investigate the Effect of Enriched Environment on the Gene Expression of Parvalbumin- and Somatostatin-Positive Interneurons in Mice." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2qc6by.

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碩士<br>國立陽明大學<br>腦科學研究所<br>106<br>Background: Inhibitory interneurons are essential for the organization and regulation of neural networks. The two major types of inhibitory interneuron, Parvalbumin-positive (PV+) and Somatostatin-positive (SST+) interneurons are essential for the information processing and memory formation in the hippocampus. Learning and memory are mediated by the experience-dependent plasticity in the neuronal circuits. However, the molecular mechanism of PV+ and SST+ interneurons during the learning process remained unclear. Here, we utilized enriched environment (EE) as a
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Części książek na temat "Somatostatin positive interneuron"

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Fasching, Liana, Melanie Brady, and Flora M. Vaccarino. "Cellular and Molecular Pathology in Tourette Syndrome." In Tourette Syndrome, 2nd ed., edited by Liana Fasching, Melanie Brady, and Flora M. Vaccarino. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197543214.003.0012.

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Abstract This chapter summarizes the available literature and data on pathological findings in Tourette syndrome. In severe, unremitting Tourette syndrome, there are decreases in somatostatin-positive/nitric oxide synthase–positive interneurons, fast spiking parvalbumin-positive/γ-aminobutyric acid-ergic interneurons, as well as tonically active cholinergic interneurons in the caudate nucleus and putamen. There is also a prominent increase in inflammation throughout the basal ganglia along with activation of microglial cells. Overall, neuroimaging studies suggest that the basal ganglia, a set
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